Detailed information for compound 1029001

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 380.914 | Formula: C22H25ClN4
  • H donors: 1 H acceptors: 2 LogP: 4.71 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc(cc1)CN1CCC(CC1)Nc1ccc(nn1)c1ccccc1.Cl
  • InChi: 1S/C22H24N4.ClH/c1-3-7-18(8-4-1)17-26-15-13-20(14-16-26)23-22-12-11-21(24-25-22)19-9-5-2-6-10-19;/h1-12,20H,13-17H2,(H,23,25);1H
  • InChiKey: DFOMTUFSOSYRPI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus glycine receptor subunit alpha 1 0.0045 0.0239 0.0269
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0039 0.0039
Echinococcus multilocularis Polycystic kidney disease protein 0.0018 0.0017 0.0014
Trypanosoma brucei PAB1-binding protein , putative 0.0022 0.0045 0.0034
Schistosoma mansoni hypothetical protein 0.0146 0.1056 0.1208
Giardia lamblia Thioredoxin reductase 0.0095 0.0645 0.228
Brugia malayi jmjC domain containing protein 0.0088 0.0589 0.1605
Plasmodium vivax glutathione reductase, putative 0.0463 0.3642 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0062 0.0373 0.0423
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0095 0.0645 0.1748
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0095 0.0645 0.1952
Brugia malayi hypothetical protein 0.0061 0.0366 0.0992
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0022 0.0045 0.0095
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0024 0.0063 0.014
Echinococcus granulosus nAChR subunit 0.0024 0.0068 0.0072
Loa Loa (eye worm) MH2 domain-containing protein 0.0305 0.2353 0.52
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0066 0.0404 0.0459
Loa Loa (eye worm) latrophilin receptor protein 2 0.0067 0.0418 0.0925
Schistosoma mansoni ap endonuclease 0.0017 0.0011 0.0007
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0022 0.0045 0.0095
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0381 0.0432
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0095 0.0645 0.0736
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.1242 1 1
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0045 0.0239 0.0641
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0045 0.0239 0.0269
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0095 0.0645 0.3076
Echinococcus granulosus glycine receptor subunit alpha 1 0.0045 0.0239 0.0269
Brugia malayi glutamate synthase 0.0095 0.0645 0.176
Schistosoma mansoni nAChR subunit 0.0045 0.0239 0.0269
Loa Loa (eye worm) hypothetical protein 0.0045 0.0239 0.0527
Toxoplasma gondii Erv1 / Alr family protein 0.0032 0.0127 0.0322
Plasmodium vivax thioredoxin reductase, putative 0.0463 0.3642 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0045 0.0239 0.0269
Loa Loa (eye worm) hypothetical protein 0.0045 0.0239 0.0527
Echinococcus granulosus glycine receptor subunit beta 0.0045 0.0239 0.0269
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0045 0.0239 0.0641
Loa Loa (eye worm) hypothetical protein 0.0066 0.0404 0.0892
Onchocerca volvulus 0.0021 0.0039 0.0067
Toxoplasma gondii hypothetical protein 0.0066 0.0404 0.1083
Onchocerca volvulus 0.0066 0.0404 0.1189
Leishmania major lanosterol 14-alpha-demethylase, putative 0.002 0.0028 0.0018
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0017 0.0005 0.0001
Brugia malayi hypothetical protein 0.0018 0.0017 0.0033
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0068 0.0426 0.0416
Brugia malayi bZIP transcription factor family protein 0.0078 0.0502 0.1366
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0095 0.0645 0.0736
Echinococcus multilocularis chromobox protein 1 0.0064 0.0394 0.0448
Loa Loa (eye worm) hypothetical protein 0.0045 0.0239 0.0527
Loa Loa (eye worm) hypothetical protein 0.0024 0.0063 0.014
Schistosoma mansoni disulfide oxidoreductase 0.0095 0.0645 0.0736
Echinococcus multilocularis survival motor neuron protein 1 0.0219 0.1653 0.1894
Trichomonas vaginalis importin beta-1, putative 0.0022 0.0045 0.011
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0359 0.2794 0.7666
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0067 0.0418 0.1136
Brugia malayi Cation transporter family protein 0.0045 0.0239 0.0641
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0071 0.0447 0.1214
Brugia malayi Pre-SET motif family protein 0.0054 0.0309 0.0835
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0359 0.2794 0.7666
Schistosoma mansoni lamin 0.0025 0.0072 0.0077
Loa Loa (eye worm) hypothetical protein 0.0024 0.0063 0.014
Schistosoma mansoni rab6-interacting 0.0018 0.0017 0.0014
Loa Loa (eye worm) histone methyltransferase 0.0025 0.0076 0.0169
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.002 0.0028 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0024 0.0063 0.0159
Loa Loa (eye worm) hypothetical protein 0.0024 0.0063 0.014
Trypanosoma cruzi cytochrome P450, putative 0.0036 0.0159 0.0149
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0024 0.0063 0.0067
Trypanosoma cruzi hypothetical protein, conserved 0.0095 0.0645 0.0635
Brugia malayi Smad1 0.0021 0.0038 0.009
Brugia malayi MH2 domain containing protein 0.0021 0.0038 0.009
Brugia malayi Calcitonin receptor-like protein seb-1 0.0213 0.1606 0.4401
Trypanosoma brucei cytochrome P450, putative 0.0036 0.0159 0.0149
Trypanosoma cruzi NADH dehydrogenase, putative 0.0095 0.0645 0.0635
Trichomonas vaginalis glucosylceramidase, putative 0.0239 0.1817 0.5549
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.1048 0.8415 0.8413
Echinococcus granulosus mixed lineage leukemia protein mll 0.0021 0.0039 0.0039
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0045 0.0239 0.0269
Loa Loa (eye worm) heterochromatin protein 1 0.0064 0.0394 0.0871
Echinococcus granulosus zinc finger protein 0.0024 0.006 0.0064
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0068 0.0426 0.1279
Loa Loa (eye worm) hypothetical protein 0.0045 0.0239 0.0527
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0045 0.0239 0.0527
Trichomonas vaginalis chromobox protein, putative 0.0064 0.0394 0.1182
Mycobacterium ulcerans NADH dehydrogenase 0.0095 0.0645 0.228
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0068 0.0426 0.1493
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0045 0.0239 0.0641
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0019 0.0021 0.0042
Trichomonas vaginalis glucosylceramidase, putative 0.0239 0.1817 0.5549
Schistosoma mansoni acetylcholine receptor-related 0.0021 0.0039 0.004
Schistosoma mansoni hypothetical protein 0.0027 0.0089 0.0096
Schistosoma mansoni glutamate synthase 0.0095 0.0645 0.0736
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0095 0.0645 0.0736
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.002 0.0028 0.0063
Schistosoma mansoni cytochrome P450 0.002 0.0028 0.0027
Schistosoma mansoni sodium/chloride dependent transporter 0.0066 0.0404 0.0459
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0045 0.0239 0.0641
Onchocerca volvulus 0.0021 0.0039 0.0067
Onchocerca volvulus 0.0045 0.0239 0.068
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.002 0.0029 0.005
Echinococcus multilocularis cpg binding protein 0.0082 0.054 0.0615
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0088 0.0589 0.0671
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0021 0.0039 0.004
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.027 0.2074 0.6336
Trichomonas vaginalis ap endonuclease, putative 0.0017 0.0011 0.0004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1242 1 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0239 0.0527
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0021 0.0039 0.0087
Echinococcus multilocularis L aminoadipate semialdehyde 0.0077 0.0496 0.0564
Onchocerca volvulus Alhambra homolog 0.0027 0.0089 0.0219
Loa Loa (eye worm) hypothetical protein 0.003 0.011 0.0244
Mycobacterium ulcerans hypothetical protein 0.0019 0.0021 0.0037
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0024 0.0063 0.0067
Loa Loa (eye worm) hypothetical protein 0.0045 0.0239 0.0527
Plasmodium falciparum LCCL domain-containing protein 0.0018 0.0017 0.0019
Brugia malayi Cytochrome P450 family protein 0.002 0.0028 0.0063
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0366 0.2856 0.6313
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0024 0.0063 0.014
Loa Loa (eye worm) hypothetical protein 0.0024 0.0068 0.015
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0263 0.2018 0.5534
Brugia malayi Latrophilin receptor protein 2 0.0067 0.0418 0.1136
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0095 0.0645 0.1748
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0068 0.0426 0.0416
Echinococcus multilocularis importin subunit beta 1 0.0027 0.0086 0.0094
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0794 0.6344 0.7285
Echinococcus granulosus thioredoxin glutathione reductase 0.0463 0.3642 0.418
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0095 0.0645 0.0635
Toxoplasma gondii isocitrate dehydrogenase 0.0042 0.0214 0.0559
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0032 0.0129 0.0366
Echinococcus granulosus jun protein 0.0078 0.0502 0.0572
Echinococcus multilocularis microtubule associated protein 2 0.0638 0.5075 0.5827
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0024 0.0063 0.0159
Brugia malayi Cation transporter family protein 0.0045 0.0239 0.0641
Echinococcus granulosus nAChR subunit 0.0045 0.0239 0.0269
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0067 0.0418 0.0475
Echinococcus granulosus mothers against decapentaplegic 5 0.0021 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0045 0.0239 0.0527
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.002 0.0033
Mycobacterium leprae conserved hypothetical protein 0.0022 0.0045 0.0088
Echinococcus multilocularis lysine specific demethylase 5A 0.0033 0.0135 0.0149
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.027 0.2074 0.6336
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0066 0.0404 0.1083
Loa Loa (eye worm) hypothetical protein 0.0024 0.0068 0.015
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.002 0.0028 0.0048
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0017 0.0005 0.0001
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0095 0.0645 0.3076
Loa Loa (eye worm) isocitrate dehydrogenase 0.0042 0.0214 0.0472
Loa Loa (eye worm) jmjC domain-containing protein 0.0056 0.0323 0.0713
Echinococcus multilocularis smad 0.0021 0.0038 0.0038
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0062 0.0373 0.0423
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0095 0.0645 0.1748
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0087
Schistosoma mansoni nAChR subunit 0.0045 0.0239 0.0269
Schistosoma mansoni neurotransmitter gated ion channel 0.0024 0.0068 0.0072
Toxoplasma gondii selenide, water dikinase 0.0095 0.0645 0.1748
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0186 0.0518
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0033 0.0074
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.027 0.2074 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0068 0.015
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0028 0.0095 0.0264
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0036 0.0163 0.0449
Loa Loa (eye worm) hypothetical protein 0.0024 0.0068 0.015
Loa Loa (eye worm) hypothetical protein 0.0069 0.0433 0.0958
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0163 0.0473
Trichomonas vaginalis glucosylceramidase, putative 0.0239 0.1817 0.5549
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0024 0.0063 0.0141
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0095 0.0645 0.1748
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0034 0.0147 0.0163
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0095 0.0645 0.1748
Loa Loa (eye worm) hypothetical protein 0.0024 0.0063 0.014
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0068 0.0426 0.1144
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.002 0.0028 0.0063
Trypanosoma brucei NADH dehydrogenase 0.0095 0.0645 0.0635
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.002 0.0029 0.005
Echinococcus granulosus sodium and chloride dependent glycine 0.0066 0.0404 0.0459
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0045 0.0239 0.0641
Brugia malayi Cytochrome P450 family protein 0.0036 0.0159 0.0424
Onchocerca volvulus 0.0095 0.0645 0.1932
Loa Loa (eye worm) hypothetical protein 0.0387 0.3021 0.6677
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.002 0.0028 0.0063
Onchocerca volvulus Protein ultraspiracle homolog 0.0024 0.0063 0.0141
Brugia malayi hypothetical protein 0.0219 0.1653 0.453
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.002 0.0028 0.0048
Brugia malayi Heterochromatin protein 1 0.0064 0.0394 0.107
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0024 0.0063 0.0067
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0063 0.0067
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0024 0.0063 0.0067
Loa Loa (eye worm) inositol-1 0.0068 0.0426 0.0942
Schistosoma mansoni chromobox protein 0.0064 0.0394 0.0448
Loa Loa (eye worm) ACC-1 protein 0.0045 0.0239 0.0527
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0087
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0087
Echinococcus granulosus sodium and chloride dependent glycine 0.0066 0.0404 0.0459
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0918 0.7354 0.7351
Plasmodium vivax ferrodoxin reductase, putative 0.0095 0.0645 0.1748
Leishmania major hypothetical protein, conserved 0.0095 0.0645 0.0635
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.1216 0.3704
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0071 0.0447 0.1202
Schistosoma mansoni steroid hormone receptor ad4bp 0.0024 0.0063 0.0067
Schistosoma mansoni nAChR subunit 0.0045 0.0239 0.0269
Brugia malayi Thioredoxin reductase 0.0463 0.3642 1
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0239 0.1817 0.4016
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0066 0.0404 0.1096
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0213 0.1606 0.4401
Trypanosoma brucei importin beta-1 subunit, putative 0.0027 0.0086 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0024 0.0063 0.0159
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0095 0.0645 0.2252
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0387 0.3021 0.3466
Onchocerca volvulus 0.0024 0.0063 0.0141
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0042 0.0214 0.0203
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.002 0.0028 0.0063
Trypanosoma cruzi cytochrome P450, putative 0.0036 0.0159 0.0149
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0071 0.0447 0.1202
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0024 0.0063 0.0159
Leishmania major NADH dehydrogenase, putative 0.0095 0.0645 0.0635
Echinococcus multilocularis serotonin receptor 0.0571 0.4525 0.5194
Brugia malayi hypothetical protein 0.0062 0.0373 0.101
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0024 0.0063 0.0067
Echinococcus multilocularis nAChR subunit 0.0024 0.0068 0.0072
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0045 0.0239 0.0269
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0095 0.0645 0.0635
Schistosoma mansoni cpg binding protein 0.0076 0.0489 0.0557
Schistosoma mansoni voltage-gated potassium channel 0.0037 0.0173 0.0193
Plasmodium falciparum glutathione reductase 0.0359 0.2794 0.7666
Toxoplasma gondii PHD-finger domain-containing protein 0.0027 0.0089 0.0215
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0095 0.0645 0.1952
Schistosoma mansoni hypothetical protein 0.0095 0.0645 0.0736
Onchocerca volvulus 0.0066 0.0404 0.1189
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0021 0.0039 0.0093
Trichomonas vaginalis glucosylceramidase, putative 0.0239 0.1817 0.5549
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0095 0.0645 0.1748
Echinococcus multilocularis PHD finger protein rhinoceros 0.0027 0.0089 0.0096
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0021 0.0039 0.0093
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0019 0.0021 0.0037
Schistosoma mansoni lipoxygenase 0.0076 0.0491 0.0558
Echinococcus multilocularis isocitrate dehydrogenase 0.0042 0.0214 0.024
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0066 0.0404 0.0459
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0063 0.0067
Schistosoma mansoni sulfide quinone reductase 0.0095 0.0645 0.0736
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0021 0.0039 0.004
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0024 0.0063 0.0067
Schistosoma mansoni hypothetical protein 0.0018 0.0017 0.0014
Brugia malayi MH2 domain containing protein 0.0021 0.0038 0.009
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0067 0.0418 0.0475
Loa Loa (eye worm) acetylcholine receptor protein 0.0021 0.0039 0.0087
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0087
Mycobacterium ulcerans monoxygenase 0.0095 0.0645 0.228
Brugia malayi Bromodomain containing protein 0.0078 0.0503 0.1368
Echinococcus granulosus dnaJ subfamily B 0.1084 0.8707 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.002 0.0029 0.0064
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0024 0.0068 0.0072
Entamoeba histolytica hypothetical protein 0.0022 0.0045 0.0167
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.002 0.0028 0.0063
Brugia malayi cytochrome P450 0.002 0.0028 0.0063
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0359 0.2794 0.3205
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0024 0.0063 0.0159
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0024 0.0063 0.014
Schistosoma mansoni smad1 5 8 and 0.0021 0.0038 0.0038
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.002 0.0028 0.0048
Toxoplasma gondii LsmAD domain-containing protein 0.0022 0.0045 0.0095
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0025 0.0076 0.0082
Brugia malayi hypothetical protein 0.0018 0.0017 0.0033
Trichomonas vaginalis glucosylceramidase, putative 0.0157 0.1147 0.3492
Trichomonas vaginalis chromobox protein, putative 0.0064 0.0394 0.1182
Onchocerca volvulus 0.0025 0.0072 0.0168
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0032 0.0127 0.0141
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0045 0.0239 0.0269
Trichomonas vaginalis glucosylceramidase, putative 0.0157 0.1147 0.3492
Schistosoma mansoni hypothetical protein 0.0067 0.0418 0.0475
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0263 0.2018 0.5534
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0039
Echinococcus granulosus L aminoadipate semialdehyde 0.0077 0.0496 0.0564
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0087
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0095 0.0645 0.228
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0024 0.0063 0.0067
Echinococcus multilocularis mothers against decapentaplegic 5 0.0021 0.0038 0.0038
Schistosoma mansoni retinoic acid receptor RXR 0.0024 0.0063 0.0067
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0095 0.0264
Brugia malayi chromobox protein homolog 3 0.0036 0.0163 0.0434
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0381 0.0432
Mycobacterium tuberculosis Probable oxidoreductase 0.0359 0.2794 0.7666
Trypanosoma cruzi cytochrome p450-like protein, putative 0.002 0.0028 0.0018
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0066 0.0404 0.1096
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0042 0.0214 0.024
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0022 0.0045 0.0115
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0045 0.0239 0.0269
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0095 0.0645 0.1952
Schistosoma mansoni mixed-lineage leukemia protein mll 0.003 0.011 0.0121
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0045 0.0239 0.0269
Loa Loa (eye worm) hypothetical protein 0.0066 0.0404 0.0892
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0095 0.0645 0.228
Schistosoma mansoni survival motor neuron protein 0.0045 0.0233 0.0262
Mycobacterium ulcerans endonuclease IV 0.0071 0.0447 0.1568
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0024 0.0063 0.014
Schistosoma mansoni hypothetical protein 0.0067 0.0418 0.0475
Loa Loa (eye worm) hypothetical protein 0.0045 0.0239 0.0527
Echinococcus granulosus lipoxygenase domain containing protein 0.0018 0.0017 0.0014
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0045 0.0239 0.0269
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0045 0.0239 0.0527
Schistosoma mansoni biogenic amine (5HT) receptor 0.0571 0.4525 0.5194
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0063 0.0067
Chlamydia trachomatis thioredoxin reductase 0.0095 0.0645 0.2183
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0095 0.0645 0.0635
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0063 0.0159
Brugia malayi jmjC domain containing protein 0.0039 0.0186 0.0496
Trichomonas vaginalis inositol monophosphatase, putative 0.0068 0.0426 0.1279
Leishmania major trypanothione reductase 0.0463 0.3642 0.3635
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0071 0.0445 0.0506
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0021 0.0039 0.004
Schistosoma mansoni sulfide quinone reductase 0.0095 0.0645 0.0736
Brugia malayi RNA, U transporter 1 0.0076 0.0487 0.1326
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0095 0.0645 0.0736
Schistosoma mansoni jun-related protein 0.0063 0.0384 0.0435
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0918 0.7354 0.7351
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.002 0.0028 0.0048
Leishmania major hypothetical protein, conserved 0.0032 0.0127 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.002 0.003 0.0064
Loa Loa (eye worm) hypothetical protein 0.0022 0.0045 0.0099
Onchocerca volvulus 0.0045 0.0239 0.068
Schistosoma mansoni lipoxygenase 0.0109 0.0758 0.0866
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0024 0.0063 0.014
Loa Loa (eye worm) hypothetical protein 0.0077 0.0496 0.1096
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0063 0.0159
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.002 0.0028 0.0063
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0095 0.0645 0.1952
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0095 0.0645 0.228
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0095 0.0645 0.1748
Schistosoma mansoni hypothetical protein 0.002 0.0033 0.0033
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0159 0.0352
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.1048 0.8415 0.8413
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.002 0.0028 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0077 0.0209
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.027 0.2074 0.6336
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0087
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0095 0.0645 0.228
Trypanosoma brucei hypothetical protein, conserved 0.0022 0.0045 0.0035
Loa Loa (eye worm) LGC-31 protein 0.0045 0.0239 0.0527
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0045 0.0239 0.0269
Mycobacterium ulcerans epimerase 0.0019 0.0021 0.0037
Trichomonas vaginalis glucosylceramidase, putative 0.0157 0.1147 0.3492
Echinococcus granulosus snurportin 1 0.0285 0.2191 0.2513
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0045 0.0239 0.0641
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0045 0.0239 0.0527
Echinococcus multilocularis 0.002 0.0028 0.0027
Echinococcus granulosus FTZ F1 alpha 0.0024 0.0063 0.0067
Loa Loa (eye worm) hypothetical protein 0.0571 0.4525 1
Toxoplasma gondii isocitrate dehydrogenase 0.0042 0.0214 0.0559
Echinococcus multilocularis musashi 0.0025 0.0072 0.0077
Brugia malayi MH2 domain containing protein 0.0305 0.2353 0.6455
Mycobacterium ulcerans dehydrogenase 0.0095 0.0645 0.228
Schistosoma mansoni loxhd1 0.0018 0.0017 0.0014
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0095 0.0645 0.1748
Onchocerca volvulus 0.0045 0.0239 0.068
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0918 0.7354 0.7351
Brugia malayi exodeoxyribonuclease III family protein 0.0017 0.0011 0.0014
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0061 0.0368 0.1251
Brugia malayi CXXC zinc finger family protein 0.0076 0.0489 0.1331
Brugia malayi PHD-finger family protein 0.0029 0.0103 0.0268
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0021 0.0039 0.0093
Schistosoma mansoni hypothetical protein 0.1084 0.8707 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0418 0.0925
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0068 0.0426 0.1493
Echinococcus granulosus inositol monophosphatase 1 0.0068 0.0426 0.0484
Giardia lamblia Glutamate synthase 0.0095 0.0645 0.228
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0077 0.0209
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0024 0.0068 0.0172
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.002 0.0028 0.0048
Trichomonas vaginalis ap endonuclease, putative 0.0017 0.0011 0.0004
Trypanosoma brucei hypothetical protein, conserved 0.0095 0.0645 0.0635
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.002 0.0028 0.0063
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0095 0.0645 0.228
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0028 0.0095 0.0264
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0109 0.0758 0.0866
Loa Loa (eye worm) hypothetical protein 0.004 0.0194 0.0429
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0095 0.0645 0.0635
Brugia malayi PHD-finger family protein 0.0027 0.0089 0.0229
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0032 0.0129 0.0366
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0159 0.0352
Brugia malayi Steroid receptor seven-up type 2 0.0024 0.0063 0.0159
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0095 0.0645 0.0736
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0024 0.0068 0.0172
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0024 0.0063 0.0067
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0066 0.0404 0.0892
Leishmania major cytochrome p450-like protein 0.002 0.0028 0.0018
Schistosoma mansoni sodium/chloride dependent transporter 0.0066 0.0404 0.0459
Loa Loa (eye worm) hypothetical protein 0.0045 0.0239 0.0527
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0087
Schistosoma mansoni nAChR subunit 0.0045 0.0239 0.0269
Schistosoma mansoni bromodomain containing protein 0.0066 0.0409 0.0465
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0045 0.0239 0.0269
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0359 0.2794 0.2787
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0021 0.0039 0.004
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0032 0.0127 0.0117
Toxoplasma gondii Erv1 / Alr family protein 0.0032 0.0127 0.0322
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0095 0.0645 0.0736
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0021 0.0039 0.0093
Onchocerca volvulus Putative nachr subunit 0.0045 0.0239 0.068
Schistosoma mansoni acetylcholine receptor subunit beta 0.0021 0.0039 0.004
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.002 0.0029 0.0065
Brugia malayi hypothetical protein 0.0021 0.0039 0.0093
Echinococcus granulosus chromobox protein 1 0.0064 0.0394 0.0448
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0095 0.0645 0.3076
Mycobacterium ulcerans ferredoxin reductase 0.0095 0.0645 0.228
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0067 0.0418 0.0475
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.002 0.0028 0.0048
Loa Loa (eye worm) hypothetical protein 0.0045 0.0239 0.0527
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0359 0.2794 1
Schistosoma mansoni glutamate synthase 0.0095 0.0645 0.0736
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.002 0.0029 0.0018
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.002 0.0028 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0063 0.0159
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.1216 0.3704
Onchocerca volvulus 0.0045 0.0239 0.068
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0066 0.0404 0.1083
Treponema pallidum oxidoreductase 0.0095 0.0645 0.2108
Echinococcus multilocularis lipoxygenase domain containing protein 0.0018 0.0017 0.0014
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0095 0.0645 0.228
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0095 0.0645 0.228
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0077 0.0496 0.1349
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0045 0.0239 0.0269
Echinococcus multilocularis dnaJ subfamily B 0.1084 0.8707 1
Schistosoma mansoni sodium-dependent amino acid transporter 0.0066 0.0404 0.0459
Loa Loa (eye worm) CYP4Cod1 0.0036 0.0159 0.0352
Echinococcus multilocularis Smad4 0.0021 0.0038 0.0038
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0063 0.0159
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0359 0.2794 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0045 0.0239 0.0641
Echinococcus granulosus GPCR family 2 0.0067 0.0418 0.0475
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0918 0.7354 0.7351
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0095 0.0645 0.3076
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0095 0.0645 0.2252
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0045 0.0239 0.0269
Loa Loa (eye worm) hypothetical protein 0.0045 0.0239 0.0527
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0071 0.0447 0.1202
Echinococcus granulosus microtubule associated protein 2 0.0638 0.5075 0.5827
Schistosoma mansoni cpg binding protein 0.0082 0.054 0.0615
Echinococcus granulosus peregrin 0.0029 0.0108 0.0118
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.002 0.0028 0.0063
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0032 0.0127 0.0141
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0024 0.0063 0.0067
Trichomonas vaginalis glutamate synthase, putative 0.0095 0.0645 0.1952
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0025 0.0072 0.0159
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0021 0.0038 0.0038
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0066 0.0404 0.1083
Loa Loa (eye worm) hypothetical protein 0.0046 0.0246 0.0543
Treponema pallidum thioredoxin reductase (trxB) 0.0095 0.0645 0.2108
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0077 0.0496 0.0564
Brugia malayi isocitrate dehydrogenase 0.0042 0.0214 0.0573
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0054 0.0309 0.0349
Brugia malayi intermediate filament protein 0.0025 0.0072 0.0184
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.002 0.0028 0.0018
Loa Loa (eye worm) hypothetical protein 0.0071 0.0447 0.0988
Echinococcus granulosus ecdysone induced protein 78C 0.0024 0.0063 0.0067
Plasmodium falciparum ferrodoxin reductase-like protein 0.0095 0.0645 0.1748
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0095 0.0645 0.228
Trichomonas vaginalis glucosylceramidase, putative 0.0239 0.1817 0.5549
Trichomonas vaginalis chromobox protein, putative 0.0039 0.0186 0.0541
Onchocerca volvulus 0.0045 0.0239 0.068
Echinococcus multilocularis glycine receptor subunit beta 0.0045 0.0239 0.0269
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0063 0.0067
Echinococcus granulosus serotonin transporter 0.0387 0.3021 0.3466
Echinococcus granulosus geminin 0.0768 0.613 0.7039
Echinococcus granulosus PHD finger protein rhinoceros 0.0027 0.0089 0.0096
Echinococcus granulosus neuropeptide receptor A26 0.0441 0.3464 0.3975
Brugia malayi steroid hormone receptor 0.0024 0.0063 0.0159
Loa Loa (eye worm) hypothetical protein 0.0024 0.0068 0.015
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0095 0.0645 0.228
Loa Loa (eye worm) hypothetical protein 0.0024 0.0068 0.015
Trypanosoma cruzi hypothetical protein, conserved 0.0095 0.0645 0.0635
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0045 0.0239 0.0269
Mycobacterium leprae Conserved hypothetical protein 0.002 0.0028 0.0027
Echinococcus granulosus smad 0.0021 0.0038 0.0038
Brugia malayi hypothetical protein 0.0021 0.0039 0.0093
Entamoeba histolytica hypothetical protein 0.0062 0.0373 0.1754
Mycobacterium tuberculosis Probable reductase 0.0095 0.0645 0.1748
Entamoeba histolytica hypothetical protein 0.0024 0.0068 0.0278
Leishmania major cytochrome p450-like protein 0.0036 0.0159 0.0149
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.002 0.0028 0.0063
Trypanosoma cruzi trypanothione reductase, putative 0.0359 0.2794 0.2787
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0095 0.0645 0.0635
Schistosoma mansoni nAChR subunit 0.0021 0.0039 0.004
Plasmodium falciparum ataxin-2 like protein, putative 0.0022 0.0045 0.0095
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.002 0.0028 0.0048
Plasmodium vivax multidomain scavenger receptor, putative 0.0018 0.0017 0.0019
Plasmodium vivax ataxin-2 like protein, putative 0.0022 0.0045 0.0095
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0095 0.0645 0.1748
Schistosoma mansoni smad1 5 8 and 0.0021 0.0038 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0063 0.0159
Loa Loa (eye worm) CHromoDomain protein family member 0.0017 0.0005 0.0012
Echinococcus multilocularis lamin 0.0025 0.0072 0.0077
Brugia malayi MH1 domain containing protein 0.0021 0.0038 0.009
Loa Loa (eye worm) transcription factor SMAD2 0.0305 0.2353 0.52
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0042 0.0214 0.0559
Plasmodium vivax hypothetical protein, conserved 0.0066 0.0404 0.1083
Onchocerca volvulus Bile acid receptor homolog 0.0024 0.0063 0.0141
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0359 0.2794 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0359 0.2794 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.002 0.0029 0.0018
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0045 0.0239 0.0269
Loa Loa (eye worm) steroid hormone receptor 0.0024 0.0063 0.014
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0021 0.0039 0.0087
Loa Loa (eye worm) MH2 domain-containing protein 0.0021 0.0038 0.0084
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0028 0.0062
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0034 0.0147 0.0389
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0032 0.0127 0.0322
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0042 0.0214 0.024
Loa Loa (eye worm) hypothetical protein 0.0045 0.0239 0.0527
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.003 0.0064
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0066 0.0404 0.0459
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0024 0.0063 0.0067
Trichomonas vaginalis glucosylceramidase, putative 0.0157 0.1147 0.3492
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0186 0.0208
Trichomonas vaginalis glucosylceramidase, putative 0.0157 0.1147 0.3492
Treponema pallidum sodium- and chloride- dependent transporter 0.0387 0.3021 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0404 0.0892
Echinococcus multilocularis peregrin 0.0029 0.0108 0.0118
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0095 0.0645 0.1748
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0359 0.2794 1
Plasmodium falciparum importin beta, putative 0.0027 0.0086 0.0208
Loa Loa (eye worm) hypothetical protein 0.0038 0.0175 0.0387
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0095 0.0645 0.0635
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0045 0.0239 0.0641
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0095 0.0645 0.1748
Echinococcus granulosus importin subunit beta 1 0.0027 0.0086 0.0094
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.002 0.0028 0.0048
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0024 0.0063 0.0067
Loa Loa (eye worm) PHD-finger family protein 0.0027 0.0089 0.0196
Loa Loa (eye worm) GABA receptor subunit 0.0024 0.0068 0.015
Leishmania major hypothetical protein, conserved 0.0095 0.0645 0.0635
Trichomonas vaginalis glutathione reductase, putative 0.0359 0.2794 0.8547
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0095 0.0645 0.1952
Loa Loa (eye worm) solute carrier family 6 member 4 0.0387 0.3021 0.6677
Echinococcus multilocularis sodium and chloride dependent glycine 0.0066 0.0404 0.0459
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0095 0.0645 0.1952
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0359 0.2794 0.7666
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0213 0.1606 0.3549
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0032 0.0127 0.0322
Loa Loa (eye worm) hypothetical protein 0.0024 0.0068 0.0151
Toxoplasma gondii HEAT repeat-containing protein 0.0027 0.0086 0.0208
Loa Loa (eye worm) hypothetical protein 0.0387 0.3021 0.6677
Onchocerca volvulus 0.0065 0.0395 0.1161
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0017 0.0011 0.0023
Loa Loa (eye worm) hypothetical protein 0.0213 0.1606 0.3549
Leishmania major cytochrome p450-like protein 0.002 0.0028 0.0018
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0024 0.0068 0.0072
Loa Loa (eye worm) hypothetical protein 0.0071 0.0445 0.0984
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0087
Schistosoma mansoni ran 0.002 0.0029 0.0028
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0095 0.0645 0.228
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0095 0.0645 0.1748
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0042 0.0214 0.0203
Leishmania major hypothetical protein, conserved 0.0022 0.0045 0.0034
Loa Loa (eye worm) hypothetical protein 0.0024 0.0068 0.015
Schistosoma mansoni RAR-like nuclear receptor 0.0024 0.0063 0.0067
Treponema pallidum fructose-bisphosphate aldolase 0.027 0.2074 0.6853
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0156 0.0173
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0022 0.0045 0.0124
Schistosoma mansoni ran 0.002 0.0029 0.0028
Echinococcus multilocularis glycine receptor subunit beta 0.0045 0.0239 0.0269
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.005 0.028 0.0316
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0359 0.2794 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0095 0.0645 0.176
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0032 0.0127 0.0117
Entamoeba histolytica hypothetical protein 0.0062 0.0373 0.1754
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0045 0.0239 0.0269
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0024 0.0068 0.0172
Schistosoma mansoni hypothetical protein 0.0063 0.0384 0.0435
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0095 0.0645 0.0736
Echinococcus multilocularis glutamate synthase 0.0095 0.0645 0.0736
Echinococcus granulosus lamin dm0 0.0025 0.0072 0.0077
Loa Loa (eye worm) Smad1 0.0021 0.0038 0.0084
Plasmodium vivax SET domain protein, putative 0.0054 0.0309 0.0821
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.002 0.0028 0.0048
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0087
Trypanosoma cruzi PAB1-binding protein , putative 0.0022 0.0045 0.0034
Schistosoma mansoni hypothetical protein 0.0062 0.0373 0.0423
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0066 0.0404 0.0459
Loa Loa (eye worm) hypothetical protein 0.0045 0.0239 0.0527
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.002 0.0028 0.0063
Loa Loa (eye worm) serotonin transporter b 0.0387 0.3021 0.6677
Loa Loa (eye worm) hypothetical protein 0.0387 0.3021 0.6677
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0066 0.0404 0.0459
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0067 0.0418 0.0475
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0156 0.0173
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.002 0.0028 0.0063
Giardia lamblia PHD finger protein 15 0.0027 0.0089 0.028
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0032 0.0127 0.0117
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0045 0.0239 0.0269
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0042 0.0214 0.0203
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0054 0.0309 0.0821
Echinococcus multilocularis zinc finger protein 0.0024 0.006 0.0064
Schistosoma mansoni hypothetical protein 0.0285 0.2191 0.2513
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0095 0.0645 0.176
Onchocerca volvulus 0.0387 0.3021 0.9242
Loa Loa (eye worm) hypothetical protein 0.0024 0.0063 0.014
Plasmodium falciparum phd finger protein, putative 0.0027 0.0089 0.0215
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0095 0.0645 0.1952
Loa Loa (eye worm) hypothetical protein 0.0045 0.0239 0.0527
Echinococcus multilocularis neuropeptide receptor A26 0.0441 0.3464 0.3975
Schistosoma mansoni hypothetical protein 0.0067 0.0418 0.0475
Toxoplasma gondii histone lysine methyltransferase SET1 0.0148 0.1079 0.2942
Echinococcus granulosus GTP binding nuclear protein Ran 0.002 0.0029 0.0028
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0021 0.0039 0.0093
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0095 0.0645 0.0736
Mycobacterium ulcerans glutamate synthase subunit beta 0.0095 0.0645 0.228
Trypanosoma brucei importin beta-1 subunit, putative 0.0027 0.0086 0.0076
Schistosoma mansoni cpg binding protein 0.0082 0.054 0.0615
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0046
Trichomonas vaginalis glucosylceramidase, putative 0.0157 0.1147 0.3492
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0039 0.0039
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.002 0.0028 0.0063
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.027 0.2074 0.6336
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0087
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0024 0.0063 0.0067
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0186 0.041
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0132 0.0946 0.2576
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0042 0.0214 0.0203
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0042 0.0214 0.0559
Toxoplasma gondii PHD-finger domain-containing protein 0.0027 0.0089 0.0215
Onchocerca volvulus Glucosylceramidase homolog 0.0157 0.1147 0.3476
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1048 0.8415 0.8413
Schistosoma mansoni inositol monophosphatase 0.0068 0.0426 0.0484
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0025 0.0076 0.0082
Brugia malayi hypothetical protein 0.0066 0.0404 0.1096
Onchocerca volvulus 0.0066 0.0404 0.1189
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0071 0.0445 0.0506
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0022 0.0045 0.0124
Echinococcus multilocularis serotonin receptor 0.0571 0.4525 0.5194
Brugia malayi hypothetical protein 0.0022 0.0045 0.0109
Toxoplasma gondii thioredoxin reductase 0.0463 0.3642 1
Brugia malayi Importin beta-1 subunit 0.0027 0.0086 0.0222
Plasmodium falciparum amino acid transporter, putative 0.0066 0.0404 0.1083
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0066 0.0404 0.0459
Schistosoma mansoni smad1 5 8 and 0.0021 0.0038 0.0038
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0022 0.0045 0.0095
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.002 0.0028 0.0018
Treponema pallidum NADH oxidase 0.0359 0.2794 0.9246
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0061 0.0368 0.0983
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0084 0.0091
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0066 0.0404 0.0459
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0359 0.2794 0.7666
Schistosoma mansoni rab6-interacting 0.0018 0.0017 0.0014
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0087
Schistosoma mansoni zinc finger protein 0.0024 0.006 0.0064
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0087
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0132 0.0946 0.336
Echinococcus granulosus TGF beta signal transducer SmadC 0.0021 0.0038 0.0038
Brugia malayi Isocitrate dehydrogenase 0.0042 0.0214 0.0573
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0021 0.0039 0.0093
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0359 0.2794 0.3205
Echinococcus granulosus jumonji domain containing protein 0.0038 0.0175 0.0195
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0042 0.0214 0.024
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0066 0.0404 0.0459
Loa Loa (eye worm) hypothetical protein 0.0066 0.0404 0.0892
Entamoeba histolytica Ran family GTPase 0.002 0.0029 0.0088
Plasmodium falciparum thioredoxin reductase 0.0463 0.3642 1
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.002 0.0028 0.0063
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0066 0.0404 0.0459
Loa Loa (eye worm) hypothetical protein 0.0024 0.0068 0.015
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0078 0.0502 0.0572
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.002 0.0028 0.0048
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.002 0.0028 0.0048
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.027 0.2074 0.6336
Echinococcus multilocularis sodium and chloride dependent glycine 0.0066 0.0404 0.0459
Brugia malayi hypothetical protein 0.0021 0.0039 0.0093
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0042 0.0214 0.024
Loa Loa (eye worm) hypothetical protein 0.0066 0.0404 0.0892
Onchocerca volvulus 0.0025 0.0072 0.0168
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0045 0.0239 0.0641
Brugia malayi Intermediate filament tail domain containing protein 0.0025 0.0072 0.0184
Loa Loa (eye worm) CXXC zinc finger family protein 0.0076 0.0489 0.1081
Echinococcus granulosus intermediate filament protein 0.0025 0.0072 0.0077
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0045 0.0239 0.0641
Entamoeba histolytica hypothetical protein 0.0022 0.0045 0.0167
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0063 0.0159
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0095 0.0264
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0095 0.0645 0.0736
Echinococcus multilocularis chromobox protein 1 0.0064 0.0394 0.0448
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.027 0.2074 0.6336
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0387 0.3021 0.8293
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0045 0.0239 0.0269
Echinococcus granulosus glycine receptor subunit beta 0.0045 0.0239 0.0269
Onchocerca volvulus 0.0076 0.0489 0.1452
Leishmania major hypothetical protein, conserved 0.0095 0.0645 0.0635
Trichomonas vaginalis ran, putative 0.002 0.0029 0.006
Loa Loa (eye worm) hypothetical protein 0.0024 0.0063 0.014
Schistosoma mansoni polycystin 1-related 0.0018 0.0017 0.0014
Schistosoma mansoni nAChR subunit 0.0045 0.0239 0.0269
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0045 0.0239 0.0641
Echinococcus granulosus chromobox protein 1 0.0064 0.0394 0.0448
Schistosoma mansoni neurotransmitter gated ion channel 0.0021 0.0039 0.004
Echinococcus granulosus biogenic amine 5HT receptor 0.0571 0.4525 0.5194
Loa Loa (eye worm) hepatopoietin HPO2 0.0032 0.0127 0.0282
Toxoplasma gondii NADPH-glutathione reductase 0.0359 0.2794 0.7666
Leishmania major phosphopantetheinyl transferase-like protein 0.0022 0.0045 0.0035
Loa Loa (eye worm) hypothetical protein 0.0028 0.01 0.022
Schistosoma mansoni voltage-gated potassium channel 0.0037 0.0173 0.0193
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0066 0.0404 0.0892
Echinococcus multilocularis lipoxygenase domain containing protein 0.0018 0.0017 0.0014
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0095 0.0645 0.1952
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0095 0.0645 0.1748
Trypanosoma brucei trypanothione reductase 0.0463 0.3642 0.3635
Loa Loa (eye worm) norepinephrine transporter 0.0387 0.3021 0.6677
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0024 0.0063 0.0159
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0022 0.0045 0.011
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0095 0.0645 0.1952
Trichomonas vaginalis glucosylceramidase, putative 0.0157 0.1147 0.3492
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0024 0.0063 0.0067
Brugia malayi Pre-SET motif family protein 0.0366 0.2856 0.784
Brugia malayi latrophilin 2 splice variant baaae 0.0146 0.1056 0.289
Trypanosoma cruzi trypanothione reductase, putative 0.0463 0.3642 0.3635
Loa Loa (eye worm) hypothetical protein 0.0146 0.1056 0.2334
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0021 0.0028
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0186 0.0208
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0042 0.0214 0.0559
Loa Loa (eye worm) hypothetical protein 0.0045 0.0239 0.0527
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0024 0.0063 0.014
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.002 0.0028 0.0018
Loa Loa (eye worm) hypothetical protein 0.0095 0.0645 0.1426
Loa Loa (eye worm) hypothetical protein 0.0046 0.0245 0.0541
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0039
Echinococcus granulosus histone lysine methyltransferase setb 0.0071 0.0445 0.0506
Onchocerca volvulus 0.0024 0.0068 0.0155
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0045 0.0239 0.0527
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0095 0.0645 0.176
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0088 0.0589 0.0671
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0095 0.0264
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0066 0.0404 0.1305
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0285 0.2191 0.4843
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0045 0.0239 0.0527
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0063 0.0067
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1048 0.8415 0.8413
Leishmania major GTP-binding protein, putative 0.002 0.0029 0.0018
Loa Loa (eye worm) hypothetical protein 0.0045 0.0239 0.0527
Trichomonas vaginalis glucosylceramidase, putative 0.0239 0.1817 0.5549
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0132 0.0946 0.3336
Echinococcus granulosus lamin 0.0025 0.0072 0.0077
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0359 0.2794 0.7669
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0042 0.0214 0.024
Schistosoma mansoni transcription factor LCR-F1 0.0062 0.0373 0.0423
Onchocerca volvulus 0.0417 0.3267 1
Brugia malayi ecdysteroid receptor 0.0024 0.0063 0.0159
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0017 0.0011 0.0007
Brugia malayi glutathione reductase 0.0463 0.3642 1
Echinococcus multilocularis inositol monophosphatase 1 0.0068 0.0426 0.0484
Schistosoma mansoni inositol monophosphatase 0.0068 0.0426 0.0484
Loa Loa (eye worm) hypothetical protein 0.0066 0.0404 0.0892
Echinococcus multilocularis ecdysone induced protein 78C 0.0024 0.0063 0.0067
Schistosoma mansoni hypothetical protein 0.0045 0.0233 0.0262
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0186 0.0208
Echinococcus granulosus Polycystic kidney disease protein 0.0018 0.0017 0.0014
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0078 0.0502 0.0572
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0017 0.0011 0.0007
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.027 0.2074 0.6336
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.002 0.0028 0.0048
Brugia malayi F/Y-rich N-terminus family protein 0.0036 0.0161 0.0428
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0045 0.0239 0.0269
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.002 0.0029 0.005
Schistosoma mansoni importin beta-1 0.0027 0.0086 0.0094
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0095 0.0645 0.0635
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0359 0.2794 0.2787
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0087
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0095 0.0645 0.0736
Echinococcus multilocularis geminin 0.0768 0.613 0.7039
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0095 0.0645 0.1748
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0045 0.0239 0.0641
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.002 0.0028 0.0048
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.002 0.0028 0.0048
Echinococcus granulosus RUN 0.0018 0.0017 0.0014
Echinococcus multilocularis GTP binding nuclear protein Ran 0.002 0.0029 0.0028
Onchocerca volvulus 0.0077 0.0496 0.1472
Loa Loa (eye worm) cytochrome P450 0.002 0.0028 0.0062
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0095 0.0645 0.0736
Loa Loa (eye worm) hypothetical protein 0.0036 0.0163 0.0361
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0045 0.0233 0.0625
Schistosoma mansoni lamin 0.0025 0.0072 0.0077
Echinococcus multilocularis thyroid hormone receptor alpha 0.0024 0.0063 0.0067
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0042 0.0214 0.0203
Loa Loa (eye worm) hypothetical protein 0.0219 0.1653 0.3653
Brugia malayi Doublecortin family protein 0.0018 0.0017 0.0033
Brugia malayi photoreceptor-specific nuclear receptor 0.0024 0.0063 0.0159
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0021 0.0039 0.004
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.001 0.0022
Loa Loa (eye worm) ACC-1 protein 0.0045 0.0239 0.0527
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0032 0.0127 0.0117
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.002 0.0028 0.0063
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0022 0.0045 0.011
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0359 0.2794 0.7666
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0027 0.0089 0.0096
Loa Loa (eye worm) intermediate filament protein 0.0025 0.0072 0.0159
Schistosoma mansoni nAChR subunit 0.0045 0.0239 0.0269
Plasmodium falciparum glutathione reductase 0.0463 0.3642 1
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.002 0.0028 0.0063
Trypanosoma cruzi NADH dehydrogenase, putative 0.0095 0.0645 0.0635
Schistosoma mansoni nAChR subunit 0.0045 0.0239 0.0269
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0045 0.0239 0.0269
Echinococcus multilocularis thioredoxin glutathione reductase 0.0463 0.3642 0.418
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0095 0.0645 0.1748
Schistosoma mansoni glutamate synthase 0.0095 0.0645 0.0736
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.002 0.0028 0.0063
Plasmodium vivax importin-beta 2, putative 0.0027 0.0086 0.0208
Onchocerca volvulus 0.0045 0.0239 0.068
Schistosoma mansoni smad 0.0021 0.0038 0.0038
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.002 0.0028 0.0063
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0045 0.0239 0.0269
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0024 0.0063 0.0067
Echinococcus multilocularis nAChR subunit 0.0045 0.0239 0.0269
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0022 0.0045 0.0124
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0095 0.0645 0.1426
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0068 0.0426 0.0416
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0034 0.0147 0.0325
Plasmodium falciparum transporter, putative 0.0066 0.0404 0.1083
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0045 0.0239 0.0269
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1242 1 1
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0066 0.0404 0.1096
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0019 0.0021 0.001
Schistosoma mansoni intermediate filament proteins 0.0025 0.0072 0.0077
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0089 0.0215
Trypanosoma cruzi PAB1-binding protein , putative 0.0022 0.0045 0.0034
Onchocerca volvulus 0.0024 0.0068 0.0155
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.002 0.0028 0.0048
Loa Loa (eye worm) hypothetical protein 0.0024 0.0063 0.014
Brugia malayi MH1 domain containing protein 0.0021 0.0038 0.009
Brugia malayi Cation transporter family protein 0.0045 0.0239 0.0641
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0071 0.0445 0.0506
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0163 0.1201 0.1374
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0017 0.0005 0.0001
Entamoeba histolytica hypothetical protein 0.0062 0.0373 0.1754
Schistosoma mansoni hypothetical protein 0.0067 0.0418 0.0475
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0359 0.2794 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0018 0.0017 0.0014
Entamoeba histolytica hypothetical protein 0.0062 0.0373 0.1754
Echinococcus granulosus cytochrome P450 2K1 0.002 0.0028 0.0027
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0084 0.0091
Loa Loa (eye worm) hypothetical protein 0.0024 0.0068 0.015
Echinococcus multilocularis GPCR, family 2 0.0067 0.0418 0.0475
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0045 0.0239 0.0269
Schistosoma mansoni neurotransmitter gated ion channel 0.0021 0.0039 0.004
Brugia malayi Bromodomain containing protein 0.0029 0.0108 0.0281
Schistosoma mansoni hypothetical protein 0.0768 0.613 0.7039
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0024 0.0063 0.0159
Schistosoma mansoni ap endonuclease 0.0017 0.0011 0.0007
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0066 0.0404 0.0459
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0087
Schistosoma mansoni chromobox protein 0.0064 0.0394 0.0448
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0066 0.0404 0.0459
Trichomonas vaginalis mercuric reductase, putative 0.0359 0.2794 0.8547
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0021 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0027 0.0086 0.0191
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0045 0.0239 0.0641
Chlamydia trachomatis endonuclease IV 0.0071 0.0447 0.1462
Plasmodium falciparum ataxin-2 like protein, putative 0.0022 0.0045 0.0095
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0066 0.0404 0.0459
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0045 0.0239 0.0641
Schistosoma mansoni hypothetical protein 0.002 0.0028 0.0027
Loa Loa (eye worm) MH1 domain-containing protein 0.0021 0.0038 0.0084
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0095 0.0645 0.0635
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0095 0.0645 0.1748
Echinococcus granulosus glycine receptor subunit alpha 1 0.0045 0.0239 0.0269
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0359 0.2794 0.2787
Echinococcus multilocularis jumonji domain containing protein 0.0038 0.0175 0.0195
Schistosoma mansoni coup transcription factor 0.0024 0.0063 0.0067
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0095 0.0264
Entamoeba histolytica disulphide oxidoreductase, putative 0.0095 0.0645 0.3076
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0054 0.0309 0.0349
Trichomonas vaginalis set domain proteins, putative 0.0417 0.3267 1
Toxoplasma gondii endonuclease IV APN 0.0071 0.0447 0.1202
Plasmodium vivax amine transporter, putative 0.0066 0.0404 0.1083
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.002 0.0029 0.0018
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0068 0.0426 0.0416
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0036 0.0159 0.0535
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0087
Giardia lamblia NADH oxidase lateral transfer candidate 0.0359 0.2794 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0066 0.0404 0.0459
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0084 0.0091
Brugia malayi Inositol-1 0.0068 0.0426 0.1157
Brugia malayi Augmenter of liver regeneration 0.0032 0.0127 0.0336
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0095 0.0645 0.0635
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0095 0.0645 0.1748
Leishmania major importin beta-1 subunit, putative 0.0022 0.0045 0.0035
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0022 0.0045 0.0095
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0045 0.0239 0.0641
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0021 0.0038 0.0038
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0045 0.0239 0.0527
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0095 0.0645 0.2252
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0045 0.0239 0.0269
Loa Loa (eye worm) hypothetical protein 0.0076 0.0485 0.1072
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0359 0.2794 0.2787
Brugia malayi Cytochrome P450 family protein 0.0036 0.0159 0.0424
Loa Loa (eye worm) hypothetical protein 0.0066 0.0404 0.0892
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0063 0.0067
Mycobacterium leprae putative cytochrome p450 0.002 0.0028 0.0027
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0109 0.0758 0.0866
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0068 0.0426 0.2014
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0068 0.0426 0.1279
Brugia malayi nuclear hormone receptor 0.0024 0.0063 0.0159
Trichomonas vaginalis chromobox protein, putative 0.0039 0.0186 0.0541
Trichomonas vaginalis glutamate synthase, putative 0.0095 0.0645 0.1952
Loa Loa (eye worm) hypothetical protein 0.0025 0.0072 0.0159
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.002 0.0028 0.0063
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0359 0.2794 0.7666
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0359 0.2794 0.7666
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0045 0.0239 0.0269
Echinococcus multilocularis snurportin 1 0.0285 0.2191 0.2513
Echinococcus granulosus survival motor neuron protein 1 0.0219 0.1653 0.1894
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.027 0.2074 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0045 0.0239 0.0641
Brugia malayi Bromodomain containing protein 0.0037 0.0175 0.0465
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0034 0.0147 0.0163
Brugia malayi hypothetical protein 0.0021 0.0039 0.0093
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.002 0.0029 0.0066
Echinococcus multilocularis lamin dm0 0.0025 0.0072 0.0077
Trypanosoma cruzi importin beta-1 subunit, putative 0.0022 0.0045 0.0035
Brugia malayi hypothetical protein 0.0021 0.0039 0.0093
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0024 0.0063 0.014
Loa Loa (eye worm) hypothetical protein 0.0045 0.0239 0.0527
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.027 0.2074 0.6336
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0359 0.2794 0.3205
Brugia malayi nuclear receptor NHR-88 0.0024 0.0063 0.0159
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0071 0.0447 0.1537
Schistosoma mansoni jumonji domain containing protein 0.007 0.0441 0.0501
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0066 0.0404 0.0459
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0095 0.0645 0.2252
Trichomonas vaginalis apoptosis inducing factor, putative 0.0095 0.0645 0.1952
Loa Loa (eye worm) hypothetical protein 0.0024 0.0063 0.014
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0042 0.0214 0.024
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0095 0.0645 0.228
Loa Loa (eye worm) hypothetical protein 0.0571 0.4525 1
Loa Loa (eye worm) doublecortin family protein 0.0018 0.0017 0.0039
Onchocerca volvulus 0.0021 0.0039 0.0067
Schistosoma mansoni sodium/chloride dependent transporter 0.0387 0.3021 0.3466
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0463 0.3642 1
Mycobacterium ulcerans hypothetical protein 0.0095 0.0645 0.228
Echinococcus multilocularis RUN 0.0018 0.0017 0.0014
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0095 0.0645 0.0736
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0095 0.0645 0.3076
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0063 0.0159
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0063 0.0067
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0095 0.0645 0.1952
Loa Loa (eye worm) glutathione reductase 0.0463 0.3642 0.8049
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0095 0.0645 0.1748
Echinococcus granulosus neuropeptide s receptor 0.0441 0.3464 0.3975
Toxoplasma gondii cytochrome p450 superfamily protein 0.002 0.0028 0.0048
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0095 0.0645 0.0635
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0095 0.0645 0.1748
Schistosoma mansoni hypothetical protein 0.0768 0.613 0.7039
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0359 0.2794 0.7666
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0024 0.0068 0.0172
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0095 0.0264
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.002 0.0028 0.0048
Echinococcus multilocularis serotonin transporter 0.0387 0.3021 0.3466
Loa Loa (eye worm) hypothetical protein 0.0027 0.0089 0.0196
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.002 0.0028 0.0063
Loa Loa (eye worm) programmed cell death 8 0.0095 0.0645 0.1426
Brugia malayi excitatory GABA receptor EXP-1A 0.0045 0.0239 0.0641
Onchocerca volvulus 0.0045 0.0233 0.0662
Mycobacterium tuberculosis Probable dehydrogenase 0.0095 0.0645 0.1748
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0022 0.0045 0.0095
Loa Loa (eye worm) thioredoxin reductase 0.0463 0.3642 0.8049
Entamoeba histolytica thioredoxin reductase, putative 0.0095 0.0645 0.3076
Schistosoma mansoni microtubule-associated protein tau 0.0638 0.5075 0.5827
Brugia malayi Cytochrome P450 family protein 0.002 0.0028 0.0063
Onchocerca volvulus 0.0028 0.01 0.0253
Giardia lamblia Fructose-bisphosphate aldolase 0.027 0.2074 0.7412
Echinococcus granulosus glutamate synthase 0.0095 0.0645 0.0736
Loa Loa (eye worm) hypothetical protein 0.0045 0.0239 0.0527
Schistosoma mansoni Smad4 0.0021 0.0038 0.0038
Schistosoma mansoni nAChR subunit 0.0021 0.0039 0.004
Echinococcus granulosus Smad4 0.0021 0.0038 0.0038
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0066 0.0404 0.0459
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0066 0.0404 0.1096
Toxoplasma gondii hypothetical protein 0.0066 0.0404 0.1083
Echinococcus granulosus cpg binding protein 0.0082 0.054 0.0615
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0065 0.0395 0.0448
Plasmodium falciparum thioredoxin reductase 0.0359 0.2794 0.7666
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0063 0.0067
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.002 0.0028 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0163 0.0473
Onchocerca volvulus 0.0061 0.0366 0.1073
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0095 0.0264
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.002 0.0028 0.0063
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0239 0.1817 0.4982
Loa Loa (eye worm) hypothetical protein 0.0045 0.0239 0.0527
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0095 0.0645 0.2252
Echinococcus multilocularis FTZ F1 alpha 0.0024 0.0063 0.0067
Echinococcus multilocularis jun protein 0.0078 0.0502 0.0572
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0095 0.0645 0.0635
Echinococcus multilocularis neuropeptide s receptor 0.0441 0.3464 0.3975

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 65 uM In vitro inhibition of Torpedo californica acetylcholinesterase. ChEMBL. 10052979

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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