Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0298 | 0.5272 | 0.5108 |
Echinococcus multilocularis | carbonic anhydrase | 0.0298 | 0.5272 | 0.5272 |
Schistosoma mansoni | glutamine synthetase 1 2 (glutamate-amonia ligase) (gs) | 0.0244 | 0.4022 | 0.4022 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0298 | 0.5272 | 0.5108 |
Plasmodium falciparum | glutamine synthetase, putative | 0.0157 | 0.1977 | 0.2141 |
Loa Loa (eye worm) | Gln-2 protein | 0.0157 | 0.1977 | 0.1315 |
Leishmania major | vacuolar-type proton translocating pyrophosphatase 1, putative | 0.0347 | 0.6436 | 0.6436 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0499 | 1 | 1 |
Trypanosoma brucei | Pyrophosphate-energized vacuolar membrane proton pump 1 | 0.0347 | 0.6436 | 0.6142 |
Echinococcus multilocularis | carbonic anhydrase | 0.0298 | 0.5272 | 0.5272 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.5272 | 0.4882 |
Brugia malayi | Polyprenyl synthetase family protein | 0.0105 | 0.0762 | 0.0441 |
Trypanosoma cruzi | glutamine synthetase, putative | 0.0244 | 0.4022 | 0.3529 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.5272 | 0.4882 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0499 | 1 | 1 |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.0105 | 0.0762 | 0.5 |
Onchocerca volvulus | Glutamine synthetase homolog | 0.0157 | 0.1977 | 0.5 |
Leishmania major | farnesyl pyrophosphate synthase | 0.0105 | 0.0762 | 0.0762 |
Mycobacterium tuberculosis | Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) | 0.0105 | 0.0762 | 0.3855 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0298 | 0.5272 | 0.5272 |
Echinococcus multilocularis | carbonic anhydrase | 0.0298 | 0.5272 | 0.5272 |
Giardia lamblia | Farnesyl diphosphate synthase | 0.0105 | 0.0762 | 0.5 |
Brugia malayi | follicle stimulating hormone receptor | 0.0278 | 0.481 | 0.4629 |
Mycobacterium ulcerans | geranylgeranyl pyrophosphate synthase | 0.0105 | 0.0762 | 0.3855 |
Plasmodium falciparum | carbonic anhydrase | 0.0298 | 0.5272 | 0.7949 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0278 | 0.481 | 0.4382 |
Echinococcus granulosus | carbonic anhydrase II | 0.0499 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0499 | 1 | 1 |
Trypanosoma brucei | Pyrophosphate-energized vacuolar membrane proton pump 2, putative | 0.0347 | 0.6436 | 0.6142 |
Toxoplasma gondii | V-type H(+)-translocating pyrophosphatase VP1 | 0.0347 | 0.6436 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0298 | 0.5272 | 0.5272 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.5272 | 0.4882 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0499 | 1 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.0499 | 1 | 1 |
Schistosoma mansoni | farnesyl pyrophosphate synthase | 0.0105 | 0.0762 | 0.0762 |
Mycobacterium ulcerans | geranylgeranyl pyrophosphate synthase | 0.0105 | 0.0762 | 0.3855 |
Toxoplasma gondii | polyprenyl synthetase superfamily protein | 0.0105 | 0.0762 | 0.1184 |
Mycobacterium leprae | PROBABLE GLUTAMINE SYNTHETASE GLNA2 (GLUTAMINE SYNTHASE) (GS-II) | 0.0157 | 0.1977 | 0.5 |
Echinococcus granulosus | farnesyl pyrophosphate synthase | 0.0105 | 0.0762 | 0.0762 |
Plasmodium vivax | glutamine synthetase, putative | 0.0157 | 0.1977 | 0.2141 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0298 | 0.5272 | 0.5108 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0298 | 0.5272 | 0.4882 |
Echinococcus granulosus | carbonic anhydrase | 0.0298 | 0.5272 | 0.5272 |
Plasmodium vivax | V-type H(+)-translocating pyrophosphatase, putative | 0.0347 | 0.6436 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0298 | 0.5272 | 0.8192 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0298 | 0.5272 | 0.5108 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0298 | 0.5272 | 0.5108 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0499 | 1 | 1 |
Plasmodium falciparum | V-type H(+)-translocating pyrophosphatase, putative | 0.0347 | 0.6436 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0298 | 0.5272 | 0.5272 |
Echinococcus multilocularis | glutamine synthetase | 0.0244 | 0.4022 | 0.4022 |
Trichomonas vaginalis | geranylgeranyl diphosphate synthase, putative | 0.0105 | 0.0762 | 0.5 |
Toxoplasma gondii | glutamine synthetase, type I, putative | 0.0157 | 0.1977 | 0.3072 |
Trypanosoma cruzi | glutamine synthetase, putative | 0.0244 | 0.4022 | 0.3529 |
Trypanosoma cruzi | Vacuolar proton pyrophosphatase 1, putative | 0.0347 | 0.6436 | 0.6142 |
Echinococcus multilocularis | farnesyl pyrophosphate synthase | 0.0105 | 0.0762 | 0.0762 |
Trypanosoma brucei | glutamine synthetase, putative | 0.0244 | 0.4022 | 0.3529 |
Echinococcus granulosus | carbonic anhydrase | 0.0298 | 0.5272 | 0.5272 |
Trypanosoma cruzi | vacuolar-type proton translocating pyrophosphatase 1 | 0.0347 | 0.6436 | 0.6142 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0499 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.0298 | 0.5272 | 0.5272 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0499 | 1 | 1 |
Plasmodium falciparum | V-type K+-independent H+-translocating inorganic pyrophosphatase | 0.0347 | 0.6436 | 1 |
Mycobacterium ulcerans | glutamine synthetase GlnA1 | 0.0157 | 0.1977 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0298 | 0.5272 | 0.5272 |
Schistosoma mansoni | hypothetical protein | 0.0298 | 0.5272 | 0.5272 |
Mycobacterium ulcerans | glutamine synthetase | 0.0157 | 0.1977 | 1 |
Echinococcus granulosus | glutamine synthetase | 0.0244 | 0.4022 | 0.4022 |
Leishmania major | glutamine synthetase, putative | 0.0244 | 0.4022 | 0.4022 |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.0105 | 0.0762 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0499 | 1 | 1 |
Mycobacterium tuberculosis | Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) | 0.0157 | 0.1977 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0499 | 1 | 1 |
Plasmodium vivax | vacuolar-type H+ pumping pyrophosphatase, putative | 0.0347 | 0.6436 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
T/C (functional) | = 100 % | Antitumor activity in mice bearing Ehrlich ascites tumor cells at 100 mg/kg ip | ChEMBL. | 1469693 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.