Detailed information for compound 1029204

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 338.283 | Formula: C17H24BrNO
  • H donors: 1 H acceptors: 1 LogP: 4.68 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCN1CCCC2(CC1CC2)c1cccc(c1)O.Br
  • InChi: 1S/C17H23NO.BrH/c1-2-10-18-11-4-8-17(9-7-15(18)13-17)14-5-3-6-16(19)12-14;/h2-3,5-6,12,15,19H,1,4,7-11,13H2;1H
  • InChiKey: AZYOJGHUKROOOE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0302 0.0302
Brugia malayi intermediate filament protein 0.0062 0.0672 0.0672
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0062 0.0672 0.0672
Echinococcus granulosus neuropeptide receptor A26 0.05 0.6547 0.6547
Echinococcus multilocularis muscleblind protein 1 0.0174 0.218 0.218
Loa Loa (eye worm) hypothetical protein 0.003 0.0245 0.0245
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0098 0.0098
Brugia malayi CXXC zinc finger family protein 0.0028 0.0226 0.0226
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0022 0.0022
Schistosoma mansoni cpg binding protein 0.003 0.0248 0.0248
Onchocerca volvulus 0.0039 0.0368 0.0445
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0022 0.0022
Brugia malayi glutaminase DH11.1 0.0301 0.388 0.388
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0022 0.0022
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0157 0.1955 0.1955
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0473 0.0473
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0096 0.113 1
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0368 0.0368
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0.0022 0.5
Mycobacterium tuberculosis Probable reductase 0.0086 0.1001 0.3149
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0096 0.113 0.3554
Loa Loa (eye worm) hypothetical protein 0.0018 0.0093 0.0093
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.0022 0.0022
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0359 0.0359
Mycobacterium tuberculosis Probable oxidoreductase 0.0096 0.113 0.3554
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0332 0.4302 0.4302
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0368 0.0368
Brugia malayi Cytochrome P450 family protein 0.0053 0.0553 0.0553
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0013 0.0022 0.0068
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0093 0.0093
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0098 0.0098
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0138 0.1691 0.1691
Mycobacterium tuberculosis Conserved hypothetical protein 0.0175 0.2193 0.6899
Brugia malayi CHE-14 protein 0.0312 0.4026 0.4026
Brugia malayi RNA binding protein 0.0068 0.0764 0.0764
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.1691 0.1691
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0013 0.0022 0.0022
Echinococcus multilocularis protein patched 0.0312 0.4026 0.4026
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0359 0.0359
Echinococcus granulosus intermediate filament protein 0.0062 0.0672 0.0672
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0368 0.0368
Trichomonas vaginalis set domain proteins, putative 0.0265 0.3406 0.7376
Brugia malayi beta-lactamase 0.0039 0.0368 0.0368
Loa Loa (eye worm) hypothetical protein 0.0034 0.0302 0.0302
Echinococcus granulosus geminin 0.0168 0.2101 0.2101
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0368 0.1157
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0277 0.0277
Loa Loa (eye worm) hypothetical protein 0.0029 0.023 0.023
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0368 0.0755
Onchocerca volvulus 0.0039 0.0368 0.0445
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0067 0.075 0.075
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0332 0.4302 0.4302
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0086 0.1001 0.3149
Brugia malayi beta-lactamase family protein 0.0039 0.0368 0.0368
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0093 0.0093
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0098 0.0098
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.1691 0.1691
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0352 0.0352
Schistosoma mansoni hypothetical protein 0.0168 0.2101 0.2101
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0047 0.0473 0.0473
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0022 0.0022
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0033 0.0289 0.0289
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0093 0.0093
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0757 1 1
Brugia malayi Intermediate filament tail domain containing protein 0.0062 0.0672 0.0672
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.003 0.0245 0.0245
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0022 0.0022
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0098 0.0308
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0332 0.4302 0.4302
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0022 0.0022
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0098 0.2305
Loa Loa (eye worm) hypothetical protein 0.0039 0.0368 0.0368
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0625 0.0625
Toxoplasma gondii thioredoxin reductase 0.0038 0.0352 0.6045
Plasmodium vivax glutathione reductase, putative 0.0038 0.0352 0.9555
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0368 0.0755
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0764 0.0764
Brugia malayi Thioredoxin reductase 0.0038 0.0352 0.0352
Brugia malayi cytoplasmic intermediate filament protein 0.0033 0.0289 0.0289
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.0022 0.0022
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0022 0.0371
Trichomonas vaginalis glutaminase, putative 0.0301 0.388 0.8409
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0368 0.1157
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0067 0.075 0.236
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.1691 0.1691
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0067 0.075 0.075
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0098 0.0098
Mycobacterium ulcerans beta-lactamase 0.0039 0.0368 0.0368
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0013 0.0022 0.0022
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0022 0.0022
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0764 0.0764
Echinococcus multilocularis sterol regulatory element binding protein 0.0312 0.4026 0.4026
Mycobacterium leprae Probable lipase LipE 0.0039 0.0368 0.3256
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0138 0.1691 0.1691
Schistosoma mansoni hypothetical protein 0.0018 0.0093 0.0093
Mycobacterium tuberculosis Probable dehydrogenase 0.0086 0.1001 0.3149
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0302 0.0302
Loa Loa (eye worm) cytochrome P450 family protein 0.0053 0.0553 0.0553
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0355 0.461 1
Echinococcus multilocularis GPCR, family 2 0.0018 0.0093 0.0093
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0302 0.0302
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0093 0.0093
Onchocerca volvulus 0.0062 0.0672 0.1401
Echinococcus granulosus muscleblind protein 0.0174 0.218 0.218
Leishmania major hypothetical protein, conserved 0.0039 0.0368 0.0368
Brugia malayi hypothetical protein 0.0137 0.1683 0.1683
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0368 0.1157
Trichomonas vaginalis conserved hypothetical protein 0.0312 0.4026 0.8729
Echinococcus granulosus Niemann Pick C1 protein 0.0312 0.4026 0.4026
Onchocerca volvulus Huntingtin homolog 0.0137 0.1683 0.4581
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0368 0.0368
Mycobacterium ulcerans lipase LipD 0.0039 0.0368 0.0368
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0757 1 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0368 0.0368
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0096 0.113 0.3554
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0022 0.0022
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0022 0.0022
Brugia malayi Pre-SET motif family protein 0.0233 0.2975 0.2975
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0098 0.0098
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0302 0.0302
Echinococcus multilocularis geminin 0.0168 0.2101 0.2101
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0067 0.075 0.075
Loa Loa (eye worm) hypothetical protein 0.0039 0.0368 0.0368
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0022 0.0022
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0355 0.461 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0312 0.4026 0.4026
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0013 0.0022 0.0022
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0368 0.1157
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0086 0.1001 0.3149
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0093 0.0093
Mycobacterium tuberculosis Conserved protein 0.0039 0.0368 0.1157
Schistosoma mansoni hypothetical protein 0.0168 0.2101 0.2101
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0022 0.0022
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0098 1
Echinococcus multilocularis cpg binding protein 0.003 0.0248 0.0248
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.1691 0.1691
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0067 0.075 0.075
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0757 1 1
Echinococcus granulosus tar DNA binding protein 0.0068 0.0764 0.0764
Schistosoma mansoni cpg binding protein 0.0028 0.0226 0.0226
Schistosoma mansoni patched 1 0.0312 0.4026 0.4026
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0338 0.0338
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0368 0.0755
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0098 0.0166
Schistosoma mansoni hypothetical protein 0.0018 0.0093 0.0093
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0013 0.0022 0.0022
Schistosoma mansoni ap endonuclease 0.0019 0.0098 0.0098
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0098 0.0166
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0379 0.0379
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0338 0.0338
Toxoplasma gondii exonuclease III APE 0.0019 0.0098 0.1679
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0757 1 1
Entamoeba histolytica hypothetical protein 0.0037 0.0338 1
Echinococcus granulosus lamin dm0 0.0062 0.0672 0.0672
Loa Loa (eye worm) glutaminase 0.0301 0.388 0.388
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0764 0.0764
Loa Loa (eye worm) hypothetical protein 0.004 0.0379 0.0379
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0022 0.0371
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0249 0.3179 1
Mycobacterium ulcerans hypothetical protein 0.0175 0.2193 0.2193
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0093 0.0093
Echinococcus granulosus cytoplasmic intermediate filament protein 0.003 0.0245 0.0245
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0086 0.1001 0.3149
Schistosoma mansoni cpg binding protein 0.003 0.0248 0.0248
Schistosoma mansoni lamin 0.0062 0.0672 0.0672
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0368 0.0368
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0338 0.0338
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0757 1 1
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0368 0.1157
Plasmodium falciparum thioredoxin reductase 0.0038 0.0352 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0022 0.0022
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0098 1
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0764 0.0764
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0368 0.0755
Echinococcus multilocularis protein dispatched 1 0.0312 0.4026 0.4026
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0226 0.0226
Trichomonas vaginalis esterase, putative 0.0039 0.0368 0.0755
Onchocerca volvulus 0.0039 0.0368 0.0445
Schistosoma mansoni hypothetical protein 0.0018 0.0093 0.0093
Echinococcus granulosus lamin 0.0062 0.0672 0.0672
Echinococcus multilocularis lamin dm0 0.0062 0.0672 0.0672
Loa Loa (eye worm) hypothetical protein 0.0029 0.023 0.023
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0157 0.1955 0.1955
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0368 0.0755
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0022 0.0022
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0368 0.1157
Loa Loa (eye worm) hypothetical protein 0.0137 0.1683 0.1683
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0368 0.0368
Entamoeba histolytica hypothetical protein 0.0037 0.0338 1
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0355 0.461 1
Echinococcus multilocularis neuropeptide s receptor 0.05 0.6547 0.6547
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0098 0.0098
Brugia malayi Pre-SET motif family protein 0.0034 0.0302 0.0302
Plasmodium vivax SET domain protein, putative 0.0034 0.0302 0.8098
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0625 0.0625
Mycobacterium ulcerans hypothetical protein 0.0039 0.0368 0.0368
Loa Loa (eye worm) beta-lactamase 0.0039 0.0368 0.0368
Onchocerca volvulus 0.0062 0.0672 0.1401
Echinococcus granulosus sterol regulatory element binding protein 0.0312 0.4026 0.4026
Leishmania major trypanothione reductase 0.0038 0.0352 0.0352
Echinococcus multilocularis neuropeptide receptor A26 0.05 0.6547 0.6547
Brugia malayi hypothetical protein 0.0037 0.0338 0.0338
Schistosoma mansoni hypothetical protein 0.0037 0.0338 0.0338
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0352 0.9555
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0368 1
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0764 0.0764
Entamoeba histolytica hypothetical protein 0.0037 0.0338 1
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0368 0.3256
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0302 0.518
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0047 0.0473 0.0473
Entamoeba histolytica hypothetical protein 0.0037 0.0338 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0312 0.4026 0.4026
Schistosoma mansoni hypothetical protein 0.0018 0.0093 0.0093
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0368 0.1157
Loa Loa (eye worm) hypothetical protein 0.0757 1 1
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0764 0.0764
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0067 0.075 0.075
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0764 0.0764
Trypanosoma brucei trypanothione reductase 0.0038 0.0352 0.0352
Loa Loa (eye worm) hypothetical protein 0.0062 0.0672 0.0672
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0757 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0625 0.0625
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0368 0.0368
Brugia malayi TAR-binding protein 0.0068 0.0764 0.0764
Schistosoma mansoni lamin 0.0062 0.0672 0.0672
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0022 0.0022
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0157 0.1955 0.1955
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.1691 0.1691
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0625 0.0625
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0757 1 1
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0355 0.461 1
Echinococcus granulosus GPCR family 2 0.0018 0.0093 0.0093
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0764 0.0764
Loa Loa (eye worm) hypothetical protein 0.0174 0.218 0.218
Echinococcus granulosus Protein patched homolog 1 0.0312 0.4026 0.4026
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0067 0.075 0.075
Loa Loa (eye worm) hypothetical protein 0.006 0.0657 0.0657
Brugia malayi Muscleblind-like protein 0.0174 0.218 0.218
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0086 0.1001 0.3149
Onchocerca volvulus 0.0265 0.3406 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0669 0.0669
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0098 0.0098
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0093 0.0093
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0098 0.0166
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.004 0.0379 0.0379
Plasmodium falciparum glutathione reductase 0.0038 0.0352 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0013 0.0022 0.0022
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0022 0.0022
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.0636 0.0636
Mycobacterium ulcerans glutaminase 0.0301 0.388 0.388
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0368 0.0368
Echinococcus granulosus cpg binding protein 0.003 0.0248 0.0248
Toxoplasma gondii ABC1 family protein 0.0039 0.0368 0.6309
Brugia malayi glutathione reductase 0.0038 0.0352 0.0352
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0757 1 1
Onchocerca volvulus Huntingtin homolog 0.0137 0.1683 0.4581
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0368 0.0368
Loa Loa (eye worm) glutathione reductase 0.0038 0.0352 0.0352
Loa Loa (eye worm) hypothetical protein 0.0039 0.0368 0.0368
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0022 0.0022
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.1691 0.1691
Loa Loa (eye worm) hypothetical protein 0.0174 0.218 0.218
Loa Loa (eye worm) hypothetical protein 0.0039 0.0368 0.0368
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.1691 0.1691
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0583 1
Schistosoma mansoni glutaminase 0.0301 0.388 0.388
Mycobacterium tuberculosis Conserved protein 0.0039 0.0368 0.1157
Echinococcus granulosus neuropeptide s receptor 0.05 0.6547 0.6547
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0352 0.1109
Loa Loa (eye worm) intermediate filament protein 0.0062 0.0672 0.0672
Loa Loa (eye worm) hypothetical protein 0.0039 0.0368 0.0368
Schistosoma mansoni ap endonuclease 0.0019 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0039 0.0368 0.0368
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0352 0.0352
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0473 0.0473
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0086 0.1001 0.8859
Leishmania major mitochondrial DNA polymerase beta 0.0332 0.4302 0.4302
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0067 0.075 0.075
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0098 0.0098
Echinococcus multilocularis Niemann Pick C1 protein 0.0312 0.4026 0.4026
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0098 0.2203
Echinococcus multilocularis muscleblind protein 0.0174 0.218 0.218
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0057 0.061 0.061
Loa Loa (eye worm) glutaminase 2 0.0301 0.388 0.388
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0368 0.0368
Loa Loa (eye worm) hypothetical protein 0.0137 0.1683 0.1683
Schistosoma mansoni intermediate filament proteins 0.0062 0.0672 0.0672
Loa Loa (eye worm) hypothetical protein 0.0312 0.4026 0.4026
Loa Loa (eye worm) RNA binding protein 0.0068 0.0764 0.0764
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0302 0.0302
Onchocerca volvulus 0.0034 0.0302 0.0238
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0764 0.0764
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0302 0.0302
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0302 0.0302
Brugia malayi beta-lactamase family protein 0.0039 0.0368 0.0368
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0098 0.0098
Mycobacterium tuberculosis Conserved protein 0.0039 0.0368 0.1157
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0233 0.2975 0.2975
Toxoplasma gondii hypothetical protein 0.0054 0.0565 0.9687
Echinococcus multilocularis lamin 0.0062 0.0672 0.0672
Echinococcus multilocularis musashi 0.0062 0.0672 0.0672

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.