Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0056 | 0.0171 | 0.0171 |
Mycobacterium ulcerans | lipase LipD | 0.007 | 0.0245 | 0.0457 |
Echinococcus multilocularis | geminin | 0.0495 | 0.2443 | 0.2431 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0163 | 0.0723 | 0.0709 |
Mycobacterium tuberculosis | Conserved protein | 0.007 | 0.0245 | 0.0457 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0246 | 0.1155 | 0.111 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0056 | 0.0171 | 0.0156 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0053 | 0.0156 | 0.0106 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0136 | 0.0586 | 0.0577 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0068 | 0.0017 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0068 | 0.0017 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.007 | 0.0245 | 0.0237 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0083 | 0.0032 |
Echinococcus granulosus | cpg binding protein | 0.0182 | 0.082 | 0.0773 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0068 | 0.0233 | 0.0224 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0068 | 0.0233 | 0.0218 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0043 | 0.0102 | 0.0087 |
Toxoplasma gondii | exonuclease III APE | 0.0056 | 0.0171 | 0.0121 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0056 | 0.0171 | 0.0121 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0039 | 0.0083 | 0.0032 |
Schistosoma mansoni | alpha-glucosidase | 0.014 | 0.0606 | 0.0597 |
Mycobacterium ulcerans | beta-lactamase | 0.007 | 0.0245 | 0.0457 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.0102 | 0.0093 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.007 | 0.0245 | 0.0457 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0068 | 0.0068 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0078 | 0.0285 | 0.0269 |
Mycobacterium leprae | Probable lipase LipE | 0.007 | 0.0245 | 1 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0068 | 0.0233 | 0.0428 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.0051 | 0.0051 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0163 | 0.0723 | 0.0675 |
Schistosoma mansoni | pyruvate kinase | 0.0033 | 0.0051 | 0.0042 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.007 | 0.0245 | 0.0195 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0245 | 0.0245 |
Plasmodium vivax | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.1957 | 1 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0182 | 0.082 | 0.0812 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.1957 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.007 | 0.0245 | 0.0195 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0068 | 0.0233 | 0.0183 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0039 | 0.0083 | 0.0032 |
Echinococcus multilocularis | GPCR, family 2 | 0.0078 | 0.0285 | 0.0269 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0036 | 0.0068 | 0.0017 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0102 | 0.0102 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0246 | 0.1155 | 0.1155 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0036 | 0.0068 | 0.0017 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0364 | 0.1765 | 0.1757 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0245 | 0.0245 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0245 | 0.0245 |
Leishmania major | hypothetical protein, conserved | 0.007 | 0.0245 | 0.0195 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.1957 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0245 | 0.0245 |
Trypanosoma brucei | hypothetical protein, conserved | 0.007 | 0.0245 | 0.0195 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0056 | 0.0171 | 0.0121 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0136 | 0.0586 | 0.0537 |
Mycobacterium tuberculosis | Probable hydrolase | 0.007 | 0.0245 | 0.0457 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0036 | 0.0068 | 0.0053 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0078 | 0.0285 | 0.0235 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.0752 | 0.0752 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0036 | 0.0068 | 0.0017 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0068 | 0.0233 | 0.0183 |
Echinococcus multilocularis | pyruvate kinase | 0.0033 | 0.0051 | 0.0036 |
Plasmodium falciparum | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.1957 | 1 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0056 | 0.0171 | 0.0121 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0136 | 0.0586 | 0.0586 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0036 | 0.0068 | 0.0017 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.1957 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0102 | 0.0102 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.007 | 0.0245 | 0.0457 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0068 | 0.0017 |
Mycobacterium ulcerans | hypothetical protein | 0.0855 | 0.4299 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0068 | 0.0017 |
Leishmania major | prenyl protein specific carboxyl methyltransferase, putative | 0.1957 | 1 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0056 | 0.0171 | 0.0121 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0682 | 0.3406 | 0.3396 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0325 | 0.1564 | 0.152 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0449 | 0.2205 | 0.5071 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0051 | 0.0051 |
Echinococcus granulosus | GPCR family 2 | 0.0078 | 0.0285 | 0.0235 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0068 | 0.0233 | 0.0428 |
Onchocerca volvulus | 0.007 | 0.0245 | 0.2702 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0083 | 0.0032 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0682 | 0.3406 | 0.3372 |
Trypanosoma brucei | prenyl protein specific carboxyl methyltransferase | 0.1957 | 1 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0078 | 0.0285 | 0.0235 |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.0285 | 0.0276 |
Mycobacterium leprae | conserved hypothetical protein | 0.007 | 0.0245 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.0285 | 0.0276 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0036 | 0.0068 | 0.0017 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0056 | 0.0171 | 0.0121 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.007 | 0.0245 | 0.0457 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0102 | 0.0102 |
Schistosoma mansoni | hypothetical protein | 0.0823 | 0.4138 | 0.4133 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.1155 | 0.1155 |
Schistosoma mansoni | hypothetical protein | 0.0495 | 0.2443 | 0.2436 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0036 | 0.0068 | 0.0017 |
Echinococcus multilocularis | cpg binding protein | 0.0182 | 0.082 | 0.0806 |
Toxoplasma gondii | ABC1 family protein | 0.007 | 0.0245 | 0.0195 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0078 | 0.0285 | 0.0285 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0168 | 0.0752 | 0.0705 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0163 | 0.0723 | 0.0675 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0068 | 0.0017 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0056 | 0.0171 | 0.0121 |
Plasmodium vivax | hypothetical protein, conserved | 0.007 | 0.0245 | 0.0195 |
Brugia malayi | beta-lactamase family protein | 0.007 | 0.0245 | 0.0195 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.007 | 0.0245 | 0.0195 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.007 | 0.0245 | 0.0195 |
Mycobacterium ulcerans | hypothetical protein | 0.007 | 0.0245 | 0.0457 |
Trichomonas vaginalis | helicase, putative | 0.0039 | 0.0083 | 0.0032 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0056 | 0.0171 | 0.0282 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.007 | 0.0245 | 0.0195 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0163 | 0.0723 | 0.0709 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0056 | 0.0171 | 0.0121 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0102 | 0.0102 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.007 | 0.0245 | 0.0195 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.0102 | 0.0087 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.007 | 0.0245 | 0.0457 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0043 | 0.0102 | 0.0051 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0823 | 0.4138 | 0.4129 |
Mycobacterium tuberculosis | Conserved protein | 0.007 | 0.0245 | 0.0457 |
Echinococcus granulosus | geminin | 0.0495 | 0.2443 | 0.2404 |
Onchocerca volvulus | 0.007 | 0.0245 | 0.2702 | |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0068 | 0.0017 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0068 | 0.0233 | 0.0428 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0083 | 0.0032 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0043 | 0.0102 | 0.0051 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0682 | 0.3406 | 0.34 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0056 | 0.0171 | 0.0171 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0285 | 0.0285 |
Schistosoma mansoni | pyruvate kinase | 0.0033 | 0.0051 | 0.0042 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0039 | 0.0083 | 0.0032 |
Onchocerca volvulus | 0.0094 | 0.0368 | 0.4414 | |
Schistosoma mansoni | cpg binding protein | 0.0182 | 0.082 | 0.0812 |
Trypanosoma brucei | glucosidase, putative | 0.0036 | 0.0068 | 0.0017 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0068 | 0.0017 |
Onchocerca volvulus | 0.007 | 0.0245 | 0.2702 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0083 | 0.0032 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0036 | 0.0068 | 0.0017 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0043 | 0.0102 | 0.0093 |
Onchocerca volvulus | 0.0172 | 0.0769 | 1 | |
Schistosoma mansoni | alpha glucosidase | 0.0036 | 0.0068 | 0.0059 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0068 | 0.0017 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.007 | 0.0245 | 0.0195 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0039 | 0.0083 | 0.0032 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0246 | 0.1155 | 0.111 |
Echinococcus multilocularis | 0.1957 | 1 | 1 | |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0056 | 0.0171 | 0.0121 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0052 | 0.0153 | 0.0102 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0083 | 0.0032 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.007 | 0.0245 | 0.0195 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0102 | 0.0051 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0136 | 0.0586 | 0.0537 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0083 | 0.0032 |
Schistosoma mansoni | ap endonuclease | 0.0056 | 0.0171 | 0.0162 |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.0285 | 0.0276 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0136 | 0.0586 | 0.0571 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.1957 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0056 | 0.0171 | 0.5 |
Brugia malayi | beta-lactamase | 0.007 | 0.0245 | 0.0195 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0043 | 0.0102 | 0.0087 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0036 | 0.0068 | 0.0068 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.0102 | 0.0051 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0078 | 0.0285 | 0.0235 |
Schistosoma mansoni | ap endonuclease | 0.0056 | 0.0171 | 0.0162 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.007 | 0.0245 | 0.0457 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0039 | 0.0083 | 0.0032 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0245 | 0.0245 |
Schistosoma mansoni | alpha-glucosidase | 0.014 | 0.0606 | 0.0597 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.007 | 0.0245 | 0.0195 |
Trichomonas vaginalis | esterase, putative | 0.007 | 0.0245 | 0.0195 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.007 | 0.0245 | 0.0457 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0056 | 0.0171 | 0.0121 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.007 | 0.0245 | 0.023 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0136 | 0.0586 | 0.0577 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0136 | 0.0586 | 0.0577 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0039 | 0.0083 | 0.0032 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0056 | 0.0171 | 0.5 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.1957 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.0285 | 0.0276 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0083 | 0.0032 |
Mycobacterium tuberculosis | Conserved protein | 0.007 | 0.0245 | 0.0457 |
Schistosoma mansoni | cpg binding protein | 0.0172 | 0.0769 | 0.0761 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0078 | 0.0285 | 0.0235 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0078 | 0.0285 | 0.0269 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.007 | 0.0245 | 0.0457 |
Loa Loa (eye worm) | protein-S isoprenylcysteine O-methyltransferase | 0.1957 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical membrane protein | 0.0855 | 0.4299 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0172 | 0.0769 | 0.0722 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.007 | 0.0245 | 0.0457 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0083 | 0.0032 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.007 | 0.0245 | 0.0237 |
Brugia malayi | beta-lactamase family protein | 0.007 | 0.0245 | 0.0195 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0083 | 0.0032 |
Toxoplasma gondii | isoprenylcysteine carboxyl methyltransferase (icmt) family protein | 0.1957 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0495 | 0.2443 | 0.2436 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0039 | 0.0083 | 0.0032 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.1957 | 1 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0056 | 0.0171 | 0.0121 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0102 | 0.0093 |
Loa Loa (eye worm) | histone methyltransferase | 0.0053 | 0.0156 | 0.0156 |
Echinococcus multilocularis | pyruvate kinase | 0.0033 | 0.0051 | 0.0036 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0056 | 0.0171 | 0.0121 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0136 | 0.0586 | 0.0537 |
Echinococcus granulosus | protein S isoprenylcysteine O methyltransferase | 0.1957 | 1 | 1 |
Echinococcus granulosus | dnaJ subfamily B | 0.0823 | 0.4138 | 0.4108 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0053 | 0.0156 | 0.0141 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0136 | 0.0586 | 0.0571 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.0051 | 0.0051 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.0051 | 0.0051 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0245 | 0.0245 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0068 | 0.0233 | 0.0183 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0063 | 0.021 | 0.021 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.007 | 0.0245 | 0.0245 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0039 | 0.0083 | 0.0032 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.0752 | 0.0744 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0172 | 0.0769 | 0.0769 |
Schistosoma mansoni | protein-s-isoprenylcysteine o-methyltransferase | 0.1957 | 1 | 1 |
Chlamydia trachomatis | pyruvate kinase | 0.0033 | 0.0051 | 0.5 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0068 | 0.0068 |
Giardia lamblia | Isoprenylcysteine carboxyl methyltransferase | 0.1957 | 1 | 1 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.1957 | 1 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0056 | 0.0171 | 0.0282 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0163 | 0.0723 | 0.0723 |
Loa Loa (eye worm) | beta-lactamase | 0.007 | 0.0245 | 0.0245 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 6 mg kg-1 | Effective dose required to potentiate yohimbine hydrochloride induced lethality in mice, administered intraperitoneally | ChEMBL. | 4067998 |
ED50 (functional) | = 6.2 mg kg-1 | Effective dose required to prevent reserpine ptosis in mice, administered orally (po) | ChEMBL. | 4067998 |
ED50 (functional) | = 6.8 mg kg-1 | Effective dose required to prevent reserpine ptosis in mice, administered intraperitoneally | ChEMBL. | 4067998 |
LD50 (ADMET) | = 108 mg kg-1 | Lethal dose of the compound was determined in mouse i.p. | ChEMBL. | 4067998 |
LD50 (ADMET) | = 200 mg kg-1 | Lethal dose of the compound was determined in mouse p.o. | ChEMBL. | 4067998 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.