TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 201.225 | Formula: C11H11N3O
H donors: 3 H acceptors: 1 LogP: 0.9 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Nc1ccccc1c1ccc([nH]1)C(=O)N
InChi: 1S/C11H11N3O/c12-8-4-2-1-3-7(8)9-5-6-10(14-9)11(13)15/h1-6,14H,12H2,(H2,13,15)
InChiKey: CNKBQAZLVBKGTQ-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	hypothetical protein, conserved	0.0004	0.0082	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0004	0.0082	0.1229
Schistosoma mansoni	steroid dehydrogenase	0.0004	0.0082	0.0082
Trypanosoma brucei	3-keto-dihydrosphingosine reductase	0.0004	0.0082	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0004	0.0082	0.0082
Mycobacterium leprae	Possible short-chain dehydrogenase EphD	0.0004	0.0082	0.5
Mycobacterium tuberculosis	Probable short-chain dehydrogenase/reductase	0.0004	0.0082	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0.0082	0.5
Onchocerca volvulus		0.003	0.4403	1
Trypanosoma brucei	3-ketoacyl-CoA reductase, putative	0.0004	0.0082	0.5
Leishmania major	pteridine reductase 1	0.0004	0.0082	0.5
Trypanosoma cruzi	short chain dehydrogenase/reductase, putative	0.0004	0.0082	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.0082	0.0082
Loa Loa (eye worm)	CXXC zinc finger family protein	0.003	0.4403	0.5935
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0004	0.0082	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0004	0.0082	0.5
Mycobacterium ulcerans	short-chain dehydrogenase	0.0004	0.0082	0.5
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.0004	0.0082	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.7362	0.7362
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0956	0.1199
Entamoeba histolytica	hypothetical protein, conserved	0.0004	0.0082	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.7362	1
Schistosoma mansoni	steroid dehydrogenase	0.0004	0.0082	0.0082
Schistosoma mansoni	short-chain dehydrogenase/reductase	0.0004	0.0082	0.0082
Trypanosoma cruzi	3-ketoacyl-CoA reductase, putative	0.0004	0.0082	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0004	0.0082	0.1229
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.0082	0.0082
Mycobacterium tuberculosis	Probable dehydrogenase	0.0004	0.0082	0.5
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0004	0.0082	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0.0082	0.5
Mycobacterium ulcerans	oxidoreductase	0.0004	0.0082	0.5
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0956	0.1199
Trypanosoma cruzi	beta-ketoacyl-ACP reductase 2, putative	0.0004	0.0082	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.0082	0.5
Leishmania major	short chain dehydrogenase, putative	0.0004	0.0082	0.5
Schistosoma mansoni	cpg binding protein	0.0032	0.4688	0.4688
Schistosoma mansoni	steroid dehydrogenase	0.0004	0.0082	0.0082
Leishmania major	hypothetical protein, conserved	0.0004	0.0082	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0004	0.0082	0.1229
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0542	1
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.0082	0.0082
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0004	0.0082	0.1229
Mycobacterium tuberculosis	Probable oxidoreductase	0.0004	0.0082	0.5
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.7362	1
Mycobacterium ulcerans	3-alpha-hydroxysteroid dehydrogenase	0.0004	0.0082	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0004	0.0082	0.5
Trypanosoma cruzi	NAD(P)-dependent oxidoreductase, putative	0.0004	0.0082	0.5
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0651	0.0651
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.0651	0.0781
Schistosoma mansoni	carbonyl reductase	0.0004	0.0082	0.0082
Trichomonas vaginalis	estradiol 17 beta-dehydrogenase, putative	0.0004	0.0082	0.1229
Trypanosoma cruzi	hypothetical protein, conserved	0.0004	0.0082	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0004	0.0082	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.0082	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0004	0.0082	0.0082
Schistosoma mansoni	carbonyl reductase	0.0004	0.0082	0.0082
Schistosoma mansoni	steroid dehydrogenase	0.0004	0.0082	0.0082
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0048	0.7362	1
Mycobacterium tuberculosis	Probable shortchain dehydrogenase	0.0004	0.0082	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0542	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0.0082	0.5
Leishmania major	dehydrogenase-like protein	0.0004	0.0082	0.5
Leishmania major	hypothetical protein, conserved	0.0004	0.0082	0.5
Schistosoma mansoni	carbonyl reductase	0.0004	0.0082	0.0082
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.0082	0.0082
Mycobacterium tuberculosis	Decaprenylphosphoryl-D-2-keto erythro pentose reductase	0.0004	0.0082	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0004	0.0082	0.5
Trypanosoma brucei	beta-ketoacyl-ACP reductase 3, putative	0.0004	0.0082	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.0082	0.5
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0004	0.0082	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.0082	0.5
Entamoeba histolytica	3-ketodihydrosphingosine reductase protein, putative	0.0004	0.0082	1
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0542	1
Trypanosoma cruzi	3-ketoacyl-CoA reductase, putative	0.0004	0.0082	0.5
Mycobacterium leprae	ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE	0.0004	0.0082	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.0082	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0004	0.0082	0.1229
Trypanosoma cruzi	hypothetical protein, conserved	0.0004	0.0082	0.5
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0542	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.7362	0.7362
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0542	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0048	0.7362	1
Schistosoma mansoni	oxidoreductase short chain dehydrogenase/reductase family	0.0004	0.0082	0.0082
Mycobacterium ulcerans	dehydrogenase/reductase	0.0004	0.0082	0.5
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0004	0.0082	0.5
Mycobacterium ulcerans	short-chain dehydrogenase	0.0004	0.0082	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0542	1
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0004	0.0082	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0004	0.0082	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.0082	0.5
Mycobacterium tuberculosis	Possible oxidoreductase	0.0004	0.0082	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.0082	0.0082
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0542	1
Leishmania major	short chain dehydrogenase/reductase, putative	0.0004	0.0082	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.0082	0.5
Mycobacterium ulcerans	ketoacyl reductase	0.0004	0.0082	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0004	0.0082	0.1229
Trypanosoma cruzi	hypothetical protein, conserved	0.0004	0.0082	0.5
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0004	0.0082	0.0082
Mycobacterium tuberculosis	Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1	0.0004	0.0082	0.5
Entamoeba histolytica	hypothetical protein	0.0004	0.0082	1
Mycobacterium ulcerans	short-chain type oxidoreductase	0.0004	0.0082	0.5
Plasmodium falciparum	steroid dehydrogenase, putative	0.0004	0.0082	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0.0082	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.0082	0.0082
Leishmania major	short chain dehydrogenase/reductase, putative	0.0004	0.0082	0.5
Trypanosoma brucei	oxidoreductase-like protein	0.0004	0.0082	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0.0082	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0004	0.0082	0.0082
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0.0082	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.0082	0.5
Mycobacterium tuberculosis	Possible ketoacyl reductase	0.0004	0.0082	0.5
Trypanosoma cruzi	3-keto-dihydrosphingosine reductase	0.0004	0.0082	0.5
Giardia lamblia	Hypothetical protein	0.0004	0.0082	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0004	0.0082	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0.0082	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0004	0.0082	0.5
Mycobacterium ulcerans	dehydrogenase	0.0004	0.0082	0.5
Mycobacterium ulcerans	short-chain membrane-associated dehydrogenase	0.0004	0.0082	0.5
Mycobacterium tuberculosis	Probable short-chain type oxidoreductase	0.0004	0.0082	0.5
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0004	0.0082	1
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0004	0.0082	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0004	0.0082	0.5
Mycobacterium tuberculosis	Possible oxidoreductase	0.0004	0.0082	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0542	1
Leishmania major	hypothetical protein, conserved	0.0004	0.0082	0.5
Trypanosoma cruzi	short chain dehydrogenase, putative	0.0004	0.0082	0.5
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0651	0.0781
Schistosoma mansoni	steroid dehydrogenase	0.0004	0.0082	0.0082
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0651	0.0781
Schistosoma mansoni	steroid dehydrogenase	0.0004	0.0082	0.0082
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0.0082	0.5
Trypanosoma cruzi	short-chain dehydrogenase, putative	0.0004	0.0082	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0004	0.0082	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.0082	0.5
Schistosoma mansoni	cpg binding protein	0.0032	0.4688	0.4688
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0542	1
Echinococcus granulosus	cpg binding protein	0.0032	0.4688	0.6326
Leishmania major	oxidoreductase-like protein	0.0004	0.0082	0.5
Mycobacterium tuberculosis	Probable short chain alcohol dehydrogenase/reductase	0.0004	0.0082	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.0082	0.0082
Leishmania major	quinonoid dihydropteridine reductase	0.0004	0.0082	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.0082	0.5
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.7362	1
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0004	0.0082	0.5
Entamoeba histolytica	hypothetical protein, conserved	0.0004	0.0082	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0004	0.0082	0.5
Trichomonas vaginalis	hydroxyacyl dehydrogenase, putative	0.0004	0.0082	0.1229
Schistosoma mansoni	retinal dehydrogenase	0.0004	0.0082	0.0082
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.0082	0.0082
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0004	0.0127	0.0127
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0004	0.0082	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0542	1
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0004	0.0082	0.5
Mycobacterium tuberculosis	Possible fatty acyl-CoA reductase	0.0004	0.0082	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0004	0.0082	0.5
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0004	0.0082	0.5
Brugia malayi	CXXC zinc finger family protein	0.003	0.4403	0.5935
Entamoeba histolytica	oxidoreductase, short chain dehydrogenase/reductase family	0.0004	0.0082	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0004	0.0082	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0.0082	0.5
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0004	0.0082	0.5
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.0004	0.0082	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0004	0.0082	0.5
Trichomonas vaginalis	steroid dehydrogenase, putative	0.0004	0.0082	0.1229
Leishmania major	quinonoid dihydropteridine reductase	0.0004	0.0082	0.5
Mycobacterium tuberculosis	Possible short-chain dehydrogenase EphD	0.0004	0.0082	0.5
Mycobacterium ulcerans	ketoacyl reductase	0.0004	0.0082	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.7362	0.7362
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0004	0.0082	0.1229
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.0082	0.0082
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.0082	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0542	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0542	1
Leishmania major	short chain dehydrogenase, putative	0.0004	0.0082	0.5
Echinococcus multilocularis	cpg binding protein	0.0032	0.4688	0.6326
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0542	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.7362	1
Schistosoma mansoni	cpg binding protein	0.003	0.4403	0.4403
Trypanosoma cruzi	3-keto-dihydrosphingosine reductase	0.0004	0.0082	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.0082	0.0082
Mycobacterium ulcerans	dehydrogenase/decarboxylase protein	0.0004	0.0082	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.0082	0.0082
Mycobacterium ulcerans	short-chain dehydrogenase	0.0004	0.0082	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.0082	0.0082
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.0004	0.0082	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.0082	0.5
Mycobacterium ulcerans	oxidoreductase	0.0004	0.0082	0.5
Mycobacterium ulcerans	ketoacyl reductase	0.0004	0.0082	0.5
Entamoeba histolytica	short chain dehydrogenase family protein	0.0004	0.0082	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0542	1
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0004	0.0082	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.0082	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0.0082	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.0082	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.0082	0.5
Trypanosoma cruzi	quinonoid dihydropteridine reductase, putative	0.0004	0.0082	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.0082	0.0082
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0004	0.0082	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0004	0.0082	0.5
Trichomonas vaginalis	short-chain dehydrogenases/reductase, putative	0.0004	0.0082	0.1229
Leishmania major	short chain dehydrogenase-like protein	0.0004	0.0082	0.5
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.0004	0.0082	0.5
Leishmania major	3-keto-dihydrosphingosine reductase	0.0004	0.0082	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0004	0.0082	0.5
Giardia lamblia	Reductase, putative	0.0004	0.0082	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.0082	0.0082
Giardia lamblia	Oxidoreductase, short chain dehydrogenase/reductase family	0.0004	0.0082	0.5
Entamoeba histolytica	short chain dehydrogenase family protein	0.0004	0.0082	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.0082	0.5
Giardia lamblia	Short-chain dehydrogenase, putative	0.0004	0.0082	0.5
Plasmodium vivax	steroid dehydrogenase, putative	0.0004	0.0082	0.5
Trypanosoma brucei	beta-D-hydroxybutyrate dehydrogenase	0.0004	0.0082	0.5
Trypanosoma cruzi	short-chain dehydrogenase, putative	0.0004	0.0082	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.0082	0.5
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.0651	0.0781
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0004	0.0082	0.5
Mycobacterium ulcerans	short-chain dehydrogenase	0.0004	0.0082	0.5
Plasmodium falciparum	oxidoreductase, short-chain dehydrogenase family, putative	0.0004	0.0082	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0542	1
Trypanosoma cruzi	short chain dehydrogenase, putative	0.0004	0.0082	0.5
Mycobacterium tuberculosis	Possible iron-regulated short-chain dehydrogenase/reductase	0.0004	0.0082	0.5
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.0004	0.0082	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.0082	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0.0082	0.5
Trypanosoma cruzi	beta-ketoacyl-ACP reductase 2, putative	0.0004	0.0082	0.5
Leishmania major	hypothetical protein, conserved	0.0004	0.0082	0.5
Wolbachia endosymbiont of Brugia malayi	Short-chain alcohol dehydrogenase family enzyme	0.0004	0.0082	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.0082	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.0082	0.0082
Mycobacterium ulcerans	carveol-like dehydrogenase	0.0004	0.0082	0.5
Trypanosoma cruzi	NAD(P)-dependent oxidoreductase, putative	0.0004	0.0082	0.5
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0057	0.8869	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.0082	0.5
Mycobacterium leprae	PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE	0.0004	0.0082	0.5
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0936	0.1172
Trypanosoma cruzi	hypothetical protein, conserved	0.0004	0.0082	0.5
Mycobacterium leprae	Probable oxidoreductase	0.0004	0.0082	0.5
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0542	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.0082	0.5
Trypanosoma cruzi	short chain dehydrogenase/reductase, putative	0.0004	0.0082	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.0082	0.5
Trypanosoma brucei	beta-ketoacyl-ACP reductase 2	0.0004	0.0082	0.5
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0542	1
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0004	0.0082	0.1229
Trichomonas vaginalis	helicase, putative	0.0007	0.0542	1
Leishmania major	quinonoid dihydropteridine reductase	0.0004	0.0082	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0004	0.0082	0.0082
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0956	0.1199
Schistosoma mansoni	3-keto-dihydrosphingosine reductase	0.0004	0.0082	0.0082
Plasmodium vivax	hypothetical protein, conserved	0.0004	0.0082	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 3.07 %	Inhibition of iNOS in LPS-treated Wistar rat lung tissue homogenate assessed as conversion of L-[3H]arginine to L-[3H]citrulline at 1 mM by liquid scintillation spectroscopy	ChEMBL.	19117642
Inhibition (binding)	= 15.01 %	Inhibition of nNOS in Wistar rat striata tissue homogenate assessed as conversion of L-[3H]arginine to L-[3H]citrulline at 1 mM by liquid scintillation spectroscopy	ChEMBL.	19117642

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL541779

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1029580