Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Thromboxane-A synthase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei gambiense | cytochrome P450, putative | Thromboxane-A synthase | 533 aa | 450 aa | 20.9 % |
Trypanosoma brucei | cytochrome P450, putative | Thromboxane-A synthase | 533 aa | 450 aa | 20.9 % |
Leishmania braziliensis | cytochrome p450-like protein | Thromboxane-A synthase | 533 aa | 477 aa | 20.3 % |
Trypanosoma cruzi | cytochrome P450, putative | Thromboxane-A synthase | 533 aa | 450 aa | 20.7 % |
Dictyostelium discoideum | cytochrome P450 family protein | Thromboxane-A synthase | 533 aa | 544 aa | 19.9 % |
Trypanosoma cruzi | cytochrome P450, putative | Thromboxane-A synthase | 533 aa | 448 aa | 20.5 % |
Dictyostelium discoideum | cytochrome P450 family protein | Thromboxane-A synthase | 533 aa | 530 aa | 22.6 % |
Leishmania mexicana | cytochrome p450-like protein | Thromboxane-A synthase | 533 aa | 469 aa | 22.0 % |
Trypanosoma congolense | cytochrome P450, putative | Thromboxane-A synthase | 533 aa | 453 aa | 20.3 % |
Candida albicans | cytochrome P450 56 | Thromboxane-A synthase | 533 aa | 507 aa | 22.9 % |
Dictyostelium discoideum | cytochrome P450 family protein | Thromboxane-A synthase | 533 aa | 456 aa | 22.4 % |
Onchocerca volvulus | Thromboxane-A synthase | 533 aa | 507 aa | 21.7 % | |
Leishmania donovani | cytochrome p450-like protein | Thromboxane-A synthase | 533 aa | 473 aa | 22.2 % |
Leishmania major | cytochrome p450-like protein | Thromboxane-A synthase | 533 aa | 468 aa | 22.0 % |
Loa Loa (eye worm) | cytochrome P450 family protein | Thromboxane-A synthase | 533 aa | 480 aa | 20.8 % |
Leishmania infantum | cytochrome p450-like protein | Thromboxane-A synthase | 533 aa | 473 aa | 22.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1047 | 0.1213 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0401 | 0.0464 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0738 | 0.0855 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0738 | 0.5 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0036 | 0.0738 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0201 | 0.8632 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0738 | 0.0855 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0738 | 0.0634 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0738 | 0.0634 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0079 | 0.2768 | 0.3134 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.084 | 0.0755 |
Schistosoma mansoni | tar DNA-binding protein | 0.0201 | 0.8632 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0201 | 0.8632 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0201 | 0.8632 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0201 | 0.8632 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0201 | 0.8632 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0738 | 0.0855 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0738 | 0.0855 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.1752 | 0.2029 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.2382 | 0.2759 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0401 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0738 | 1 |
Brugia malayi | hypothetical protein | 0.0079 | 0.2768 | 0.3043 |
Entamoeba histolytica | hypothetical protein | 0.0079 | 0.2768 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0738 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0079 | 0.2768 | 0.3207 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0738 | 0.0634 |
Trichomonas vaginalis | esterase, putative | 0.0036 | 0.0738 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0401 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0201 | 0.8632 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0738 | 0.0855 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0738 | 0.0855 |
Entamoeba histolytica | hypothetical protein | 0.0079 | 0.2768 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.0887 | 0.0811 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0.0738 | 1 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0401 | 0.0234 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0079 | 0.2768 | 0.3207 |
Loa Loa (eye worm) | TAR-binding protein | 0.0201 | 0.8632 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0738 | 0.0757 |
Entamoeba histolytica | hypothetical protein | 0.0079 | 0.2768 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0059 | 0.1858 | 0.2069 |
Brugia malayi | RNA binding protein | 0.0201 | 0.8632 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0057 | 0.1752 | 0.1837 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0201 | 0.8632 | 1 |
Onchocerca volvulus | 0.0036 | 0.0738 | 0.5 | |
Onchocerca volvulus | 0.0036 | 0.0738 | 0.5 | |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.0738 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0956 | 0.1107 |
Brugia malayi | TAR-binding protein | 0.0201 | 0.8632 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0.0738 | 1 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0091 | 0.0105 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.0727 | 0.0745 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0738 | 0.0855 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0843 | 0.0977 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0738 | 0.0855 |
Schistosoma mansoni | tar DNA-binding protein | 0.0201 | 0.8632 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0738 | 0.0855 |
Onchocerca volvulus | 0.0036 | 0.0738 | 0.5 | |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0738 | 0.0634 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.0727 | 0.0745 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0.0738 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0738 | 0.0855 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0057 | 0.1752 | 0.2029 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0201 | 0.8632 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0887 | 0.1028 |
Mycobacterium ulcerans | beta-lactamase | 0.0036 | 0.0738 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0075 | 0.2585 | 0.2826 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0738 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0057 | 0.1752 | 0.1837 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0887 | 0.1028 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.0738 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0079 | 0.2768 | 0.5 |
Mycobacterium ulcerans | lipase LipD | 0.0036 | 0.0738 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0738 | 0.5 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0036 | 0.0738 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0738 | 0.5 |
Schistosoma mansoni | bromodomain containing protein | 0.0063 | 0.2028 | 0.2349 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0738 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0079 | 0.2768 | 0.3134 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0738 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0.0738 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0738 | 0.0757 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0059 | 0.1858 | 0.2069 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.