Detailed information for compound 1029959

Basic information

Technical information
  • TDR Targets ID: 1029959
  • Name: 2-benzylpiperidine hydrochloride
  • MW: 211.731 | Formula: C12H18ClN
  • H donors: 1 H acceptors: 0 LogP: 3.47 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: C1CCC(NC1)Cc1ccccc1.Cl
  • InChi: 1S/C12H17N.ClH/c1-2-6-11(7-3-1)10-12-8-4-5-9-13-12;/h1-3,6-7,12-13H,4-5,8-10H2;1H
  • InChiKey: QJPBYKFOQQDQSA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(phenylmethyl)piperidine hydrochloride

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Dopamine transporter Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) solute carrier family 6 member 4 Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni norepinephrine/norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent noradrenaline transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum IPR000175,Sodium:neurotransmitter symporter,domain-containing Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Onchocerca volvulus Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Treponema pallidum sodium- and chloride- dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Brugia malayi Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) serotonin transporter b Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus High affinity copper uptake protein 1 homolog Dopamine transporter   619 aa 599 aa 44.2 %
Plasmodium vivax hypothetical protein, conserved Dopamine transporter   619 aa 657 aa 20.1 %
Drosophila melanogaster CG1698 gene product from transcript CG1698-RA Dopamine transporter   619 aa 522 aa 36.0 %
Echinococcus granulosus sodium and chloride dependent glycine Dopamine transporter   619 aa 594 aa 41.4 %
Schistosoma japonicum ko:K05042 solute carrier family 6 (neurotransmitter transporter, glycine),, putative Dopamine transporter   619 aa 509 aa 40.1 %
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein Dopamine transporter   619 aa 636 aa 31.8 %
Onchocerca volvulus Dopamine transporter   619 aa 612 aa 23.5 %
Drosophila melanogaster CG13796 gene product from transcript CG13796-RD Dopamine transporter   619 aa 557 aa 23.9 %
Echinococcus multilocularis sodium and chloride dependent glycine Dopamine transporter   619 aa 599 aa 41.9 %
Neospora caninum sodium-dependent transporter, putative Dopamine transporter   619 aa 498 aa 32.3 %
Schistosoma mansoni sodium/chloride dependent transporter Dopamine transporter   619 aa 588 aa 40.3 %
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein Dopamine transporter   619 aa 578 aa 32.9 %
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter Dopamine transporter   619 aa 604 aa 37.9 %
Brugia malayi Sodium:neurotransmitter symporter family protein Dopamine transporter   619 aa 578 aa 33.4 %
Schistosoma mansoni sodium/chloride dependent transporter Dopamine transporter   619 aa 558 aa 41.8 %
Schistosoma japonicum ko:K05046 solute carrier family 6 (neurotransmitter transporter, GABA), member, putative Dopamine transporter   619 aa 551 aa 39.9 %
Onchocerca volvulus Transmembrane protein 120 homolog Dopamine transporter   619 aa 578 aa 32.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0022 0.0217 0.0217
Schistosoma mansoni histamine h1 receptor 0.0014 0.0065 0.0075
Brugia malayi hypothetical protein 0.0019 0.0168 0.0173
Brugia malayi hypothetical protein 0.0042 0.0594 0.0627
Onchocerca volvulus 0.0019 0.0158 0.0162
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0014 0.0065 0.0075
Schistosoma mansoni unc-13 (munc13) 0.0086 0.1388 0.1605
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0014 0.0065 0.0065
Echinococcus multilocularis unc 13 (munc13) 0.0086 0.1388 0.1388
Echinococcus granulosus serotonin receptor 0.0014 0.0065 0.0065
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0024 0.026 0.026
Schistosoma mansoni blooms syndrome DNA helicase 0.0039 0.0534 0.0617
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0105 0.1751 0.1861
Schistosoma mansoni amine GPCR 0.0014 0.0065 0.0075
Toxoplasma gondii protein kinase domain-containing protein 0.001 0.0008 0.0002
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0361 0.5822
Schistosoma mansoni cytochrome P450 reductase 0.0022 0.0217 0.0251
Entamoeba histolytica hypothetical protein 0.0042 0.0594 0.1985
Entamoeba histolytica PH domain containing protein kinase, putative 0.0173 0.2989 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0015 0.0087 0.0087
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0099 0.1637 0.1739
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0099 0.1637 0.1637
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0594 0.0687
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0022 0.0217 0.0948
Entamoeba histolytica protein kinase, putative 0.001 0.0008 0.0026
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.001 0.0008 0.0002
Schistosoma mansoni protein kinase C mu 0.0078 0.1253 0.1448
Echinococcus granulosus hypothetical protein 0.0014 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Loa Loa (eye worm) melatonin receptor type 1A 0.0014 0.0065 0.0063
Trichomonas vaginalis AGC family protein kinase 0.001 0.0008 0.0017
Brugia malayi hypothetical protein 0.0014 0.0065 0.0063
Brugia malayi intermediate filament protein 0.0032 0.0399 0.0419
Schistosoma mansoni DNA helicase recq5 0.002 0.0192 0.0222
Schistosoma mansoni diacylglycerol kinase theta 0.0078 0.1253 0.1448
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0065 0.0075
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0033 0.0424 0.2006
Schistosoma mansoni hypothetical protein 0.0078 0.1253 0.1448
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Echinococcus granulosus Diacylglycerol kinase theta 0.0078 0.1253 0.1253
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0014 0.0065 0.0065
Brugia malayi Pre-SET motif family protein 0.0245 0.4325 0.4606
Brugia malayi Serotonin receptor 0.0014 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.0324 0.5778 0.6156
Toxoplasma gondii histone lysine methyltransferase SET1 0.0065 0.1016 0.4865
Echinococcus granulosus NDR protein kinase 0.0099 0.1637 0.1637
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0014 0.0065 0.0065
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0192 0.0192
Schistosoma mansoni serine/threonine protein kinase 0.0081 0.1311 0.1516
Schistosoma mansoni neuropeptide receptor 0.0014 0.0065 0.0075
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0192 0.0198
Loa Loa (eye worm) hypothetical protein 0.0143 0.2446 0.2602
Loa Loa (eye worm) FAD binding domain-containing protein 0.0013 0.0064 0.0062
Loa Loa (eye worm) inositol-1 0.0043 0.0615 0.0649
Brugia malayi RE15519p 0.0014 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Echinococcus granulosus neuropeptide receptor 0.0014 0.0065 0.0065
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0013 0.0064 0.0074
Onchocerca volvulus 0.0032 0.0399 0.0419
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0065 0.0065
Schistosoma mansoni amine GPCR 0.0014 0.0065 0.0075
Echinococcus granulosus allatostatin A receptor 0.0014 0.0065 0.0065
Echinococcus multilocularis musashi 0.0032 0.0399 0.0399
Echinococcus multilocularis g protein coupled receptor 0.0014 0.0065 0.0065
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.001 0.0008 0.0002
Trichomonas vaginalis AGC family protein kinase 0.001 0.0008 0.0017
Loa Loa (eye worm) hypothetical protein 0.0019 0.0158 0.0162
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0139 0.2372 0.2372
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0027 0.0318 0.0318
Trichomonas vaginalis AGC family protein kinase 0.001 0.0008 0.0017
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Echinococcus granulosus dro:myosuppressin receptor 0.0014 0.0065 0.0065
Loa Loa (eye worm) runx1 0.0065 0.1017 0.1078
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0224 0.3941 0.4196
Loa Loa (eye worm) hypothetical protein 0.0078 0.1253 0.133
Onchocerca volvulus 0.0521 0.9382 1
Onchocerca volvulus 0.0014 0.0065 0.0063
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0014 0.0065 0.0065
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0027 0.0318 0.0318
Trichomonas vaginalis inositol monophosphatase, putative 0.0043 0.0615 0.1243
Toxoplasma gondii hypothetical protein 0.0019 0.0158 0.0727
Loa Loa (eye worm) hypothetical protein 0.0139 0.2372 0.2523
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.0437 0.046
Entamoeba histolytica PH domain containing protein kinase, putative 0.001 0.0008 0.0026
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Brugia malayi neuropeptide F receptor 0.0014 0.0065 0.0063
Echinococcus multilocularis serine:threonine protein kinase N2 0.0099 0.1637 0.1637
Brugia malayi hypothetical protein 0.0014 0.0065 0.0063
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0192 0.0192
Echinococcus multilocularis dnaJ subfamily B 0.0481 0.865 0.865
Loa Loa (eye worm) G-protein coupled receptor 0.0014 0.0065 0.0063
Echinococcus granulosus dual specificity 0.0105 0.1751 0.1751
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0022 0.0217 0.0217
Loa Loa (eye worm) hypothetical protein 0.0078 0.1253 0.133
Loa Loa (eye worm) hypothetical protein 0.0078 0.1253 0.133
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0065 0.0065
Schistosoma mansoni neuropeptide F-like receptor 0.0014 0.0065 0.0075
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0024 0.026 0.026
Echinococcus multilocularis allatostatin A receptor 0.0014 0.0065 0.0065
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0026 0.0302 0.1685
Brugia malayi diacylglycerol kinase 0.0078 0.1253 0.133
Echinococcus multilocularis myotubularin protein 13 0.0085 0.1386 0.1386
Loa Loa (eye worm) solute carrier family 6 member 4 0.0109 0.1829 0.1944
Entamoeba histolytica protein kinase domain containing protein 0.0105 0.1751 0.5857
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0019 0.0158 0.0162
Onchocerca volvulus 0.0221 0.3882 0.4134
Entamoeba histolytica hypothetical protein 0.0042 0.0594 0.1985
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0475 0.2255
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0594 0.0594
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0033 0.0431 0.9066
Loa Loa (eye worm) hypothetical protein 0.0032 0.0399 0.0419
Loa Loa (eye worm) hypothetical protein 0.0217 0.3807 0.4054
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0014 0.0065 0.0065
Brugia malayi FAD binding domain containing protein 0.0013 0.0064 0.0062
Echinococcus multilocularis dro:myosuppressin receptor 0.0014 0.0065 0.0065
Onchocerca volvulus 0.0014 0.0065 0.0063
Onchocerca volvulus 0.0014 0.0065 0.0063
Brugia malayi Melatonin receptor type 1A 0.0014 0.0065 0.0063
Echinococcus granulosus RNA directed DNA polymerase 0.0139 0.2372 0.2372
Brugia malayi hypothetical protein 0.0019 0.0158 0.0162
Echinococcus granulosus sex peptide receptor 0.0014 0.0065 0.0065
Schistosoma mansoni neuropeptide F-like receptor 0.0014 0.0065 0.0075
Loa Loa (eye worm) hypothetical protein 0.0086 0.1388 0.1474
Brugia malayi Protein kinase domain containing protein 0.0105 0.1751 0.1861
Leishmania major p450 reductase, putative 0.0022 0.0217 0.12
Brugia malayi AKH receptor 0.0014 0.0065 0.0063
Onchocerca volvulus 0.0036 0.0475 0.05
Loa Loa (eye worm) hypothetical protein 0.0019 0.0158 0.0162
Echinococcus granulosus tm gpcr rhodopsin 0.0014 0.0065 0.0065
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0019 0.0158 0.0162
Brugia malayi hypothetical protein 0.0014 0.0065 0.0063
Brugia malayi Pleckstrin Homology Domain 0.0085 0.1386 0.1471
Echinococcus multilocularis bloom syndrome protein 0.0049 0.0725 0.0725
Echinococcus multilocularis G-protein coupled receptor, putative 0.0014 0.0065 0.0065
Schistosoma mansoni hypothetical protein 0.0013 0.0061 0.0071
Toxoplasma gondii diacylglycerol kinase, putative 0.0078 0.1253 0.601
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0475 0.0475
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0026 0.0302 0.1687
Schistosoma mansoni opsin-like receptor 0.0014 0.0065 0.0075
Loa Loa (eye worm) hypothetical protein 0.0019 0.0158 0.0162
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0615 0.1243
Echinococcus multilocularis RNA directed DNA polymerase 0.0139 0.2372 0.2372
Schistosoma mansoni opsin-like receptor 0.0014 0.0065 0.0075
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0065 0.0065
Echinococcus granulosus g protein coupled receptor 0.0014 0.0065 0.0065
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0361 0.76
Brugia malayi ORL1-like opioid receptor 0.0014 0.0065 0.0063
Loa Loa (eye worm) TYRA-2 protein 0.0014 0.0065 0.0063
Trichomonas vaginalis AGC family protein kinase 0.0099 0.1637 0.3309
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0086 0.1388 0.1388
Echinococcus multilocularis serotonin receptor 0.0014 0.0065 0.0065
Schistosoma mansoni serine/threonine protein kinase 0.0347 0.6188 0.7154
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0065 0.0075
Brugia malayi Protein kinase c protein 2 0.0228 0.4002 0.4261
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0014 0.0065 0.0063
Echinococcus granulosus methionine synthase reductase 0.0013 0.0064 0.0064
Trypanosoma cruzi p450 reductase, putative 0.0022 0.0217 0.1202
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Echinococcus granulosus serine threonine protein kinase nrc 0.0027 0.0318 0.0318
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0019 0.0158 0.0162
Loa Loa (eye worm) FAD binding domain-containing protein 0.0022 0.0217 0.0225
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0594 0.0594
Onchocerca volvulus 0.0014 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.0324 0.5778 0.6156
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0022 0.0217 0.3538
Schistosoma mansoni serine/threonine-protein kinase 0.0035 0.0451 0.0521
Schistosoma mansoni intermediate filament proteins 0.0032 0.0399 0.0462
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0078 0.1253 0.133
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0043 0.0615 1
Trichomonas vaginalis AGC family protein kinase 0.001 0.0008 0.0017
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Entamoeba histolytica PH domain containing protein kinase, putative 0.0035 0.0451 0.1507
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0014 0.0065 0.0075
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0027 0.0318 0.669
Brugia malayi larval opioid receptor 0.0014 0.0065 0.0063
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0078 0.1253 0.1253
Entamoeba histolytica protein kinase, putative 0.0011 0.0011 0.0035
Echinococcus multilocularis neuropeptide receptor 0.0014 0.0065 0.0065
Brugia malayi hypothetical protein 0.0014 0.0065 0.0063
Trichomonas vaginalis AGC family protein kinase 0.013 0.2212 0.4473
Loa Loa (eye worm) hypothetical protein 0.003 0.0361 0.0379
Schistosoma mansoni biogenic amine receptor 0.0014 0.0065 0.0075
Echinococcus multilocularis nervana 2 0.0024 0.026 0.026
Onchocerca volvulus 0.0014 0.0065 0.0063
Schistosoma mansoni amine GPCR 0.0014 0.0065 0.0075
Brugia malayi Ras association domain family 1 isoform A 0.0078 0.1253 0.133
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.1637 0.1892
Loa Loa (eye worm) G-protein coupled receptor 0.0014 0.0065 0.0063
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0096 0.1578 0.3191
Brugia malayi hypothetical protein 0.0014 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Schistosoma mansoni cpg binding protein 0.0036 0.0472 0.0546
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.0019 0.0158 0.0162
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0324 0.5763 0.5763
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0033 0.0033
Echinococcus granulosus G protein coupled receptor 139 0.0014 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0002
Onchocerca volvulus 0.0014 0.0065 0.0063
Echinococcus multilocularis g-protein coupled receptor 0.0014 0.0065 0.0065
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.001 0.0008 0.0017
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Echinococcus granulosus serine:threonine protein kinase N2 0.0099 0.1637 0.1637
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0129 0.0131
Echinococcus granulosus neuropeptide FF receptor 2 0.0014 0.0065 0.0065
Schistosoma mansoni growth hormone secretagogue receptor 0.0014 0.0065 0.0075
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0019 0.0158 0.0183
Loa Loa (eye worm) hypothetical protein 0.0324 0.5778 0.6156
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0078 0.1253 0.1253
Echinococcus granulosus neuropeptide Y receptor 0.0014 0.0065 0.0065
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0014 0.0065 0.0075
Trichomonas vaginalis AGC family protein kinase 0.001 0.0008 0.0017
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0615 0.2751
Echinococcus granulosus intermediate filament protein 0.0032 0.0399 0.0399
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0105 0.1751 1
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.1637 0.1892
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0022 0.0217 0.12
Echinococcus granulosus fmrfamide receptor 0.0014 0.0065 0.0065
Schistosoma mansoni hypothetical protein 0.0014 0.0065 0.0075
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0014 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0031 0.0389 0.0408
Onchocerca volvulus 0.0034 0.0437 0.046
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0081 0.1311 0.1311
Entamoeba histolytica protein kinase, putative 0.001 0.0008 0.0026
Brugia malayi G protein-coupled receptor 0.0014 0.0065 0.0063
Entamoeba histolytica hypothetical protein 0.0042 0.0594 0.1985
Trichomonas vaginalis AGC family protein kinase 0.001 0.0008 0.0017
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0019 0.0158 0.0162
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0073 0.1156 0.1337
Echinococcus granulosus somatostatin receptor 0.0014 0.0065 0.0065
Echinococcus granulosus tm gpcr rhodopsin 0.0014 0.0065 0.0065
Onchocerca volvulus 0.0279 0.4946 0.5268
Echinococcus multilocularis Glutaredoxin protein 5 0.0024 0.026 0.026
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0065 0.0065
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0019 0.0158 0.0162
Echinococcus multilocularis nervana 2 0.0024 0.026 0.026
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0086 0.1388 0.1388
Echinococcus granulosus inositol monophosphatase 1 0.0043 0.0615 0.0615
Loa Loa (eye worm) RecQ helicase 0.0049 0.0725 0.0766
Brugia malayi RhoGEF domain containing protein 0.0078 0.1253 0.133
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0078 0.1253 0.133
Echinococcus multilocularis raf serine:threonine protein kinase 0.0078 0.1253 0.1253
Toxoplasma gondii flavodoxin domain-containing protein 0.0011 0.0016 0.0037
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0014 0.0065 0.0075
Schistosoma mansoni neuropeptide receptor 0.0014 0.0065 0.0075
Echinococcus multilocularis sodium and chloride dependent glycine 0.0019 0.0158 0.0158
Trichomonas vaginalis AGC family protein kinase 0.013 0.2212 0.4473
Entamoeba histolytica diacylglycerol kinase, putative 0.0078 0.1253 0.419
Trichomonas vaginalis AGC family protein kinase 0.001 0.0008 0.0017
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.1637 0.1892
Echinococcus granulosus protein kinase C gamma type 0.0245 0.4327 0.4327
Brugia malayi Protein kinase domain containing protein 0.0099 0.1637 0.1739
Onchocerca volvulus 0.0228 0.4015 0.4276
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0475 0.0475
Loa Loa (eye worm) AGC/NDR protein kinase 0.0099 0.1637 0.1739
Loa Loa (eye worm) hypothetical protein 0.0109 0.1829 0.1944
Brugia malayi flavodoxin family protein 0.0022 0.0217 0.0225
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0192 0.3024
Echinococcus multilocularis lamin dm0 0.0032 0.0399 0.0399
Onchocerca volvulus 0.0032 0.0399 0.0419
Entamoeba histolytica protein kinase 2, putative 0.0027 0.0318 0.1062
Echinococcus granulosus protein kinase c iota type 0.0274 0.4853 0.4853
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0192 0.0887
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.1637 0.1892
Echinococcus granulosus neuropeptides capa receptor 0.0014 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0099 0.1637 0.1637
Echinococcus multilocularis protein kinase c iota type 0.0274 0.4853 0.4853
Entamoeba histolytica protein kinase, putative 0.001 0.0008 0.0026
Plasmodium vivax amine transporter, putative 0.0019 0.0158 0.3326
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.001 0.0008 0.0002
Echinococcus granulosus lamin dm0 0.0032 0.0399 0.0399
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.015 0.2566 0.273
Schistosoma mansoni diflavin oxidoreductase 0.0011 0.0016 0.0018
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0065 0.0075
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Schistosoma mansoni hypothetical protein 0.0014 0.0065 0.0075
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0065 0.0065
Onchocerca volvulus 0.0014 0.0065 0.0063
Echinococcus granulosus neuropeptides capa receptor 0.0014 0.0065 0.0065
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.001 0.0008 0.0002
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0014 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0521 0.9382 1
Schistosoma mansoni sodium-dependent amino acid transporter 0.0019 0.0158 0.0183
Echinococcus multilocularis g protein coupled receptor 0.0014 0.0065 0.0065
Echinococcus granulosus unc 13 munc13 0.0086 0.1388 0.1388
Brugia malayi C1-like domain containing protein 0.0224 0.3941 0.4196
Brugia malayi Pre-SET motif family protein 0.0036 0.0475 0.05
Echinococcus multilocularis sodium and chloride dependent glycine 0.0019 0.0158 0.0158
Echinococcus multilocularis serine threonine protein kinase 0.0245 0.4327 0.4327
Loa Loa (eye worm) hypothetical protein 0.0015 0.0087 0.0087
Onchocerca volvulus 0.0014 0.0065 0.0063
Entamoeba histolytica protein kinase, putative 0.0105 0.1751 0.5857
Schistosoma mansoni myosin xvIII 0.0014 0.0065 0.0075
Trichomonas vaginalis sulfite reductase, putative 0.0022 0.0217 0.044
Loa Loa (eye worm) hypothetical protein 0.0036 0.0475 0.05
Brugia malayi putative neuropeptide receptor NPR1 0.0014 0.0065 0.0063
Echinococcus multilocularis neuropeptide Y receptor 0.0014 0.0065 0.0065
Echinococcus multilocularis Diacylglycerol kinase theta 0.0078 0.1253 0.1253
Loa Loa (eye worm) hypothetical protein 0.0085 0.1386 0.1471
Trichomonas vaginalis AGC family protein kinase 0.001 0.0008 0.0017
Schistosoma mansoni neuropeptide receptor 0.0014 0.0065 0.0075
Onchocerca volvulus 0.0014 0.0065 0.0063
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0065 0.0075
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0019 0.0158 0.0158
Schistosoma mansoni rac gtpase activating protein 0.0078 0.1253 0.1448
Schistosoma mansoni alpha-1 adrenergic receptor 0.0014 0.0065 0.0075
Schistosoma mansoni amine GPCR 0.0014 0.0065 0.0075
Schistosoma mansoni serine/threonine-protein kinase 0.0035 0.0451 0.0521
Echinococcus granulosus raf serine:threonine protein kinase 0.0078 0.1253 0.1253
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0014 0.0065 0.0075
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0014 0.0065 0.0063
Trypanosoma cruzi NIMA-related kinase, putative 0.001 0.0008 0.0002
Schistosoma mansoni vav2 0.0085 0.1386 0.1602
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0475 0.0549
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0019 0.0158 0.0162
Echinococcus multilocularis N chimaerin 0.0078 0.1253 0.1253
Echinococcus granulosus neuropeptide Y receptor 0.0014 0.0065 0.0065
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0065 0.0065
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0078 0.1253 0.133
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0019 0.0158 0.0183
Brugia malayi putative neuropeptide receptor 0.0014 0.0065 0.0063
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0014 0.0065 0.0065
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0014 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0014 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.0142 0.2435 0.259
Echinococcus multilocularis neuropeptide FF receptor 2 0.0014 0.0065 0.0065
Echinococcus granulosus Protein kinase C brain isozyme 0.0324 0.5763 0.5763
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0065 0.0065
Plasmodium vivax flavodoxin domain containing protein 0.0019 0.0172 0.3608
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0022 0.0217 0.4568
Entamoeba histolytica protein kinase, putative 0.001 0.0008 0.0026
Echinococcus granulosus cpg binding protein 0.0036 0.0472 0.0472
Trichomonas vaginalis AGC family protein kinase 0.001 0.0008 0.0017
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0019 0.0158 0.0183
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0014 0.0065 0.0065
Trichomonas vaginalis AGC family protein kinase 0.013 0.2212 0.4473
Brugia malayi Variant SH3 domain containing protein 0.0015 0.0085 0.0085
Entamoeba histolytica protein kinase, putative 0.0011 0.0011 0.0035
Schistosoma mansoni hypothetical protein 0.0481 0.865 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0078 0.1253 0.1448
Echinococcus multilocularis g protein coupled receptor 0.0014 0.0065 0.0065
Brugia malayi hypothetical protein 0.0014 0.0065 0.0063
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0192 0.0192
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.0399 0.0419
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.0143 0.2446 0.2602
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0065 0.0065
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.001 0.0008 0.0017
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0019 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0192 0.0887
Entamoeba histolytica protein kinase, putative 0.001 0.0008 0.0026
Echinococcus multilocularis sex peptide receptor 0.0014 0.0065 0.0065
Schistosoma mansoni lozenge 0.0065 0.1017 0.1175
Entamoeba histolytica recQ family DNA helicase 0.001 0.0008 0.0024
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0081 0.1311 0.1311
Loa Loa (eye worm) AGC/PKN protein kinase 0.0099 0.1637 0.1739
Echinococcus granulosus sodium and chloride dependent glycine 0.0019 0.0158 0.0158
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0475 0.0475
Loa Loa (eye worm) neuropeptide F receptor 0.0014 0.0065 0.0063
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0014 0.0065 0.0075
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0014 0.0065 0.0065
Schistosoma mansoni inositol monophosphatase 0.0043 0.0615 0.071
Brugia malayi G protein-coupled receptor F59B2.13 0.0014 0.0065 0.0063
Entamoeba histolytica protein kinase, putative 0.013 0.2212 0.7401
Schistosoma mansoni sodium/chloride dependent transporter 0.0022 0.0217 0.0251
Onchocerca volvulus 0.0109 0.1829 0.1944
Echinococcus multilocularis G protein coupled receptor 139 0.0014 0.0065 0.0065
Trypanosoma brucei rac serine-threonine kinase, putative 0.013 0.2212 1
Onchocerca volvulus 0.0014 0.0065 0.0063
Giardia lamblia Kinase, AGC PKA 0.0027 0.0318 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0192 0.0198
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.001 0.0008 0.0002
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.001 0.0008 0.0002
Schistosoma mansoni neuropeptide f receptor 76f 0.0014 0.0065 0.0075
Schistosoma mansoni serine/threonine kinase 0.0099 0.1637 0.1892
Brugia malayi FAD binding domain containing protein 0.0022 0.0217 0.0225
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0019 0.0158 0.0183
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0026 0.0302 0.1332
Onchocerca volvulus 0.0014 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.0019 0.0158 0.0162
Loa Loa (eye worm) hypothetical protein 0.002 0.0192 0.0198
Loa Loa (eye worm) hypothetical protein 0.0228 0.4015 0.4276
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0014 0.0065 0.0075
Schistosoma mansoni hypothetical protein 0.0042 0.0594 0.0687
Brugia malayi RhoGAP domain containing protein 0.0078 0.1253 0.133
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0224 0.3941 0.4196
Echinococcus granulosus nervana 2 0.0024 0.026 0.026
Echinococcus granulosus tachykinin peptides receptor 99D 0.0014 0.0065 0.0065
Onchocerca volvulus Neuropeptide F receptor homolog 0.0014 0.0065 0.0063
Onchocerca volvulus 0.0014 0.0065 0.0063
Entamoeba histolytica PH domain containing protein kinase, putative 0.0035 0.0451 0.1507
Trypanosoma cruzi rac serine-threonine kinase, putative 0.001 0.0008 0.0002
Brugia malayi Dopamine receptor protein 1 0.0014 0.0065 0.0063
Schistosoma mansoni cpg binding protein 0.0034 0.0437 0.0505
Loa Loa (eye worm) hypothetical protein 0.0019 0.0158 0.0162
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Brugia malayi hypothetical protein 0.0014 0.0065 0.0063
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0022 0.0217 0.1202
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0039 0.0531 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Entamoeba histolytica PH domain containing protein kinase, putative 0.001 0.0008 0.0026
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0192 0.0198
Toxoplasma gondii flavodoxin domain-containing protein 0.0011 0.0016 0.0037
Entamoeba histolytica p21-activated kinase 0.001 0.0008 0.0026
Entamoeba histolytica recQ family helicase, putative 0.0026 0.0302 0.1008
Loa Loa (eye worm) neuropeptide F receptor 0.0014 0.0065 0.0063
Schistosoma mansoni cpg binding protein 0.0036 0.0472 0.0546
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Treponema pallidum sodium- and chloride- dependent transporter 0.0109 0.1829 1
Plasmodium falciparum transporter, putative 0.0019 0.0158 0.2476
Echinococcus granulosus 7TM GPCR rhodopsin 0.0014 0.0065 0.0065
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0019 0.0158 0.0158
Schistosoma mansoni protein kinase C mu 0.0224 0.3941 0.4556
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Brugia malayi RhoGAP domain containing protein 0.0078 0.1253 0.133
Trichomonas vaginalis AGC family protein kinase 0.001 0.0008 0.0017
Echinococcus granulosus protein kinase c epsilon type 0.0347 0.6188 0.6188
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Onchocerca volvulus 0.0014 0.0065 0.0063
Echinococcus granulosus g protein coupled receptor 0.0014 0.0065 0.0065
Brugia malayi hypothetical protein 0.0014 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.0102 0.1692 0.1798
Echinococcus granulosus g-protein coupled receptor 0.0014 0.0065 0.0065
Plasmodium vivax SET domain protein, putative 0.0036 0.0475 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.1253 0.133
Loa Loa (eye worm) AGC/AKT protein kinase 0.013 0.2212 0.2353
Loa Loa (eye worm) hypothetical protein 0.0403 0.7214 0.7687
Schistosoma mansoni serine/threonine protein kinase 0.0324 0.5763 0.6662
Brugia malayi follicle stimulating hormone receptor 0.0014 0.0065 0.0063
Trichomonas vaginalis DNA helicase recq, putative 0.0049 0.0725 0.1465
Schistosoma mansoni DNA helicase recq1 0.002 0.0192 0.0222
Brugia malayi Serotonin receptor 0.0014 0.0065 0.0063
Trichomonas vaginalis AGC family protein kinase 0.001 0.0008 0.0017
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0065 0.0075
Echinococcus granulosus myotubularin protein 13 0.0085 0.1386 0.1386
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0014 0.0065 0.0075
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Brugia malayi Bloom's syndrome protein homolog 0.0049 0.0725 0.0766
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0014 0.0065 0.0065
Trypanosoma cruzi serine/threonine protein kinase, putative 0.001 0.0008 0.0002
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0361 0.5822
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0399 0.0419
Loa Loa (eye worm) hypothetical protein 0.0078 0.1253 0.133
Trichomonas vaginalis AGC family protein kinase 0.001 0.0008 0.0017
Echinococcus granulosus alpha 1A adrenergic receptor 0.0014 0.0065 0.0065
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0019 0.0158 0.0158
Brugia malayi Protein kinase domain containing protein 0.013 0.2212 0.2353
Plasmodium falciparum amino acid transporter, putative 0.0019 0.0158 0.2476
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0019 0.0158 0.0158
Echinococcus granulosus dnaJ subfamily B 0.0481 0.865 0.865
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0065 0.0065
Brugia malayi neuropeptide F receptor 0.0014 0.0065 0.0063
Brugia malayi Protein kinase domain containing protein 0.0099 0.1637 0.1739
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Onchocerca volvulus 0.0014 0.0065 0.0063
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0361 0.2027
Loa Loa (eye worm) hypothetical protein 0.0109 0.1829 0.1944
Onchocerca volvulus 0.0143 0.2446 0.2602
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0065 0.0075
Echinococcus granulosus N chimaerin 0.0078 0.1253 0.1253
Echinococcus granulosus tm gpcr rhodopsin 0.0014 0.0065 0.0065
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0099 0.1637 0.1637
Echinococcus granulosus 7tm_1 domain containing protein 0.0014 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0102 0.1692 0.1798
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0615 0.348
Schistosoma mansoni hypothetical protein 0.0014 0.0065 0.0075
Brugia malayi Inositol-1 0.0043 0.0615 0.0649
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0099 0.1637 0.1637
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.001 0.0008 0.0002
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0014 0.0065 0.0065
Echinococcus multilocularis lamin 0.0032 0.0399 0.0399
Entamoeba histolytica hypothetical protein 0.001 0.0008 0.0026
Loa Loa (eye worm) hypothetical protein 0.0109 0.1829 0.1944
Trichomonas vaginalis AGC family protein kinase 0.013 0.2212 0.4473
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0019 0.0158 0.0727
Brugia malayi protein kinase C3,putative 0.0178 0.3092 0.3291
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0014 0.0065 0.0075
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0014 0.0065 0.0063
Onchocerca volvulus 0.0019 0.0158 0.0162
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0347 0.6188 0.6594
Loa Loa (eye worm) serotonin transporter b 0.0109 0.1829 0.1944
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0192 0.0192
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0014 0.0065 0.0075
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0014 0.0065 0.0065
Echinococcus multilocularis fmrfamide receptor 0.0014 0.0065 0.0065
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0019 0.0158 0.0158
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0019 0.0158 0.0158
Echinococcus multilocularis neuropeptides capa receptor 0.0014 0.0065 0.0065
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0065 0.0065
Entamoeba histolytica hypothetical protein 0.001 0.0008 0.0026
Echinococcus multilocularis fmrfamide receptor 0.0014 0.0065 0.0065
Echinococcus multilocularis neuropeptide Y receptor 0.0014 0.0065 0.0065
Echinococcus multilocularis neuropeptide s receptor 0.0554 1 1
Echinococcus multilocularis neuropeptide receptor 0.0014 0.0065 0.0065
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.1751 0.2024
Trichomonas vaginalis DNA helicase recq1, putative 0.0049 0.0725 0.1465
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0033 0.0033
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0099 0.1637 0.1739
Echinococcus multilocularis methionine synthase reductase 0.0013 0.0064 0.0064
Schistosoma mansoni serine/threonine protein kinase 0.0324 0.5763 0.6662
Brugia malayi Tachykinin-like peptides receptor 99D 0.0014 0.0065 0.0063
Schistosoma mansoni hypothetical protein 0.0061 0.0934 0.108
Trichomonas vaginalis AGC family protein kinase 0.013 0.2212 0.4473
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0027 0.0318 0.1779
Loa Loa (eye worm) hypothetical protein 0.0015 0.0098 0.0098
Brugia malayi sulfakinin receptor protein 0.0014 0.0065 0.0063
Trichomonas vaginalis AGC family protein kinase 0.001 0.0008 0.0017
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0192 0.1355
Brugia malayi Dopamine receptor protein 2 0.0014 0.0065 0.0063
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0019 0.0158 0.0727
Trichomonas vaginalis AGC family protein kinase 0.001 0.0008 0.0017
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0014 0.0065 0.0065
Entamoeba histolytica hypothetical protein 0.0042 0.0594 0.1985
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0019 0.0158 0.0183
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0019 0.0158 0.0183
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0014 0.0065 0.0065
Trypanosoma cruzi NIMA-related kinase, putative 0.001 0.0008 0.0002
Echinococcus granulosus g protein coupled receptor 0.0014 0.0065 0.0065
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.0302 0.061
Trichomonas vaginalis AGC family protein kinase 0.0099 0.1637 0.3309
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Schistosoma mansoni unc-13 (munc13) 0.0086 0.1388 0.1605
Schistosoma mansoni opsin-like receptor 0.0014 0.0065 0.0075
Loa Loa (eye worm) hypothetical protein 0.0019 0.0158 0.0162
Brugia malayi p70 ribosomal S6 kinase beta 0.0123 0.2079 0.2211
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0019 0.0158 0.0183
Brugia malayi CXXC zinc finger family protein 0.0034 0.0437 0.046
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0043 0.0615 1
Echinococcus granulosus Rac GTPase activating protein 1 0.0078 0.1253 0.1253
Echinococcus granulosus serine/threonine protein kinase 0.0035 0.0451 0.0451
Trichomonas vaginalis set domain proteins, putative 0.0279 0.4946 1
Toxoplasma gondii hypothetical protein 0.0019 0.0158 0.0727
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0014 0.0065 0.0063
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0014 0.0065 0.0063
Schistosoma mansoni biogenic amine (5HT) receptor 0.0014 0.0065 0.0075
Entamoeba histolytica protein kinase, putative 0.0099 0.1637 0.5475
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0014 0.0065 0.0063
Entamoeba histolytica PH domain containing protein kinase, putative 0.001 0.0008 0.0026
Brugia malayi diacylglycerol kinase 0.0078 0.1253 0.133
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0245 0.4325 0.4606
Brugia malayi Variant SH3 domain containing protein 0.0078 0.1253 0.133
Trichomonas vaginalis AGC family protein kinase 0.001 0.0008 0.0017
Echinococcus granulosus nervana 2 0.0024 0.026 0.026
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0361 0.1706
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.001 0.0008 0.0162
Schistosoma mansoni protein kinase C 0.0086 0.1388 0.1605
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0008 0.0009
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0475 0.0549
Brugia malayi hypothetical protein 0.003 0.0361 0.0379
Echinococcus granulosus bloom syndrome protein 0.0049 0.0725 0.0725
Echinococcus granulosus neuropeptide receptor A26 0.0554 1 1
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0099 0.1637 0.1637
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0014 0.0065 0.0063
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0022 0.0217 0.1202
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0475 0.0549
Schistosoma mansoni sodium/chloride dependent transporter 0.0019 0.0158 0.0183
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0475 0.0549
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0022 0.0217 0.1202
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0065 0.0075
Echinococcus multilocularis serine:threonine protein kinase 38 0.0099 0.1637 0.1637
Trichomonas vaginalis AGC family protein kinase 0.0099 0.1637 0.3309
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0065 0.0075
Echinococcus multilocularis serine:threonine protein kinase N2 0.0261 0.4617 0.4617
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0361 0.1601
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0014 0.0065 0.0063
Schistosoma mansoni hypothetical protein 0.0014 0.0065 0.0075
Echinococcus multilocularis cpg binding protein 0.0036 0.0472 0.0472
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0022 0.0217 0.0217
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0105 0.1751 0.7907
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0014 0.0065 0.0065
Treponema pallidum ATP-dependent DNA helicase 0.001 0.0008 0.0043
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.1253 0.1448
Schistosoma mansoni biogenic amine (5HT) receptor 0.0014 0.0065 0.0075
Trichomonas vaginalis AGC family protein kinase 0.001 0.0008 0.0017
Onchocerca volvulus 0.0324 0.5778 0.6156
Loa Loa (eye worm) hypothetical protein 0.0078 0.1253 0.133
Brugia malayi G-protein coupled receptor 0.0014 0.0065 0.0063
Brugia malayi G-protein coupled receptor 0.0014 0.0065 0.0063
Entamoeba histolytica protein kinase, putative 0.0123 0.2079 0.6956
Trichomonas vaginalis AGC family protein kinase 0.001 0.0008 0.0017
Loa Loa (eye worm) RasGEF domain-containing protein 0.0078 0.1253 0.133
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0061 0.0061
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0014 0.0065 0.0075
Loa Loa (eye worm) hypothetical protein 0.0423 0.7598 0.8097
Trichomonas vaginalis AGC family protein kinase 0.001 0.0008 0.0017
Brugia malayi protein kinase C II. 0.0347 0.6188 0.6594
Loa Loa (eye worm) raf kinase 0.0078 0.1253 0.133
Entamoeba histolytica diacylglycerol kinase, putative 0.0078 0.1253 0.419
Brugia malayi hypothetical protein 0.0521 0.9382 1
Toxoplasma gondii AGC kinase 0.0123 0.2079 1
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0146 0.2505 0.2665
Brugia malayi GnHR receptor homolog 0.0014 0.0065 0.0063
Leishmania major hypothetical protein, conserved 0.003 0.0361 0.2025
Echinococcus multilocularis Rac GTPase activating protein 1 0.0078 0.1253 0.1253
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0019 0.0158 0.0183
Leishmania major cytochrome P450 reductase, putative 0.0019 0.0172 0.0938
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0014 0.0065 0.0065
Entamoeba histolytica protein kinase, putative 0.0105 0.1751 0.5857
Entamoeba histolytica hypothetical protein 0.0078 0.1253 0.419
Echinococcus multilocularis orexin receptor type 2 0.0014 0.0065 0.0065
Brugia malayi hypothetical protein 0.0014 0.0065 0.0063
Echinococcus multilocularis neuropeptide receptor A26 0.0554 1 1
Echinococcus multilocularis protein kinase c eta type 0.0078 0.1253 0.1253
Plasmodium falciparum nitric oxide synthase, putative 0.0022 0.0217 0.3448
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0014 0.0065 0.0065
Echinococcus multilocularis serotonin receptor 0.0014 0.0065 0.0065
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0098 0.0098
Echinococcus multilocularis inositol monophosphatase 1 0.0043 0.0615 0.0615
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0014 0.0065 0.0065
Schistosoma mansoni NADPH flavin oxidoreductase 0.0011 0.0019 0.0022
Brugia malayi Hr1 repeat family protein 0.0099 0.1637 0.1739
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0109 0.1829 0.2114
Echinococcus multilocularis serotonin transporter 0.0109 0.1829 0.1829
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0399 0.0419
Trichomonas vaginalis AGC family protein kinase 0.013 0.2212 0.4473
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0019 0.0172 0.0348
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0022 0.0217 0.0948
Echinococcus granulosus biogenic amine 5HT receptor 0.0014 0.0065 0.0065
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0099 0.1637 0.1637
Echinococcus granulosus biogenic amine 5HT receptor 0.0014 0.0065 0.0065
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0019 0.0158 1
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0022 0.0217 0.0948
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0065 0.0065
Echinococcus multilocularis rac serine:threonine kinase 0.0035 0.0451 0.0451
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0065 0.0065
Trichomonas vaginalis AGC family protein kinase 0.001 0.0008 0.0017
Loa Loa (eye worm) norepinephrine transporter 0.0109 0.1829 0.1944
Trypanosoma cruzi Protein kinase B 0.0035 0.0451 0.2542
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0061 0.0061
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0438 0.0438
Echinococcus multilocularis dual specificity 0.0105 0.1751 0.1751
Trichomonas vaginalis AGC family protein kinase 0.013 0.2212 0.4473
Loa Loa (eye worm) hypothetical protein 0.0221 0.3882 0.4134
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0158 0.3326
Brugia malayi hypothetical protein 0.0014 0.0065 0.0063
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0098 0.0098
Schistosoma mansoni inositol monophosphatase 0.0043 0.0615 0.071
Trichomonas vaginalis AGC family protein kinase 0.0106 0.177 0.3578
Echinococcus granulosus Glutaredoxin protein 5 0.0024 0.026 0.026
Echinococcus granulosus peptide allatostatin:somatostatin 0.0014 0.0065 0.0065
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0039 0.0531 1
Echinococcus granulosus orexin receptor type 2 0.0014 0.0065 0.0065
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0027 0.0318 0.5109
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0105 0.1751 1
Onchocerca volvulus 0.0014 0.0065 0.0063
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0043 0.0615 0.2929
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0015 0.0085 0.0085
Trichomonas vaginalis AGC family protein kinase 0.001 0.0008 0.0017
Onchocerca volvulus 0.0014 0.0065 0.0063
Brugia malayi Protein kinase domain containing protein 0.0081 0.1311 0.1392
Schistosoma mansoni sodium/chloride dependent transporter 0.0109 0.1829 0.2114
Echinococcus multilocularis Protein lozenge 0.0065 0.1017 0.1017
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0014 0.0065 0.0075
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0019 0.0158 0.0727
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0014 0.0065 0.0065
Echinococcus granulosus serotonin transporter 0.0109 0.1829 0.1829
Schistosoma mansoni lamin 0.0032 0.0399 0.0462
Entamoeba histolytica protein kinase, putative 0.013 0.2212 0.7401
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0022 0.0217 0.0948
Onchocerca volvulus 0.0014 0.0065 0.0063
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0065 0.0065
Onchocerca volvulus 0.0019 0.0158 0.0162
Schistosoma mansoni amine GPCR 0.0014 0.0065 0.0075
Echinococcus multilocularis protein kinase c epsilon type 0.0347 0.6188 0.6188
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0105 0.1751 1
Onchocerca volvulus 0.0086 0.1388 0.1474
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Schistosoma mansoni neuropeptide receptor 0.0014 0.0065 0.0075
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0043 0.0615 0.2054
Echinococcus granulosus lamin 0.0032 0.0399 0.0399
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0129 0.0131
Entamoeba histolytica hypothetical protein 0.0105 0.1751 0.5857
Schistosoma mansoni lamin 0.0032 0.0399 0.0462
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0065 0.0075
Schistosoma mansoni biogenic amine receptor 0.0014 0.0065 0.0075
Echinococcus multilocularis somatostatin receptor 0.0014 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0521 0.9382 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0014 0.0065 0.0075
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0615 0.348
Schistosoma mansoni serine/threonine protein kinase 0.0081 0.1311 0.1516
Echinococcus granulosus serine:threonine protein kinase N2 0.0165 0.2856 0.2856
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0361 0.2027
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0078 0.1253 0.1448
Schistosoma mansoni biogenic amine receptor 0.0014 0.0065 0.0075
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0109 0.1829 0.1944
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0022 0.0217 0.0217
Schistosoma mansoni diacylglycerol kinase theta 0.0078 0.1253 0.1448
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0014 0.0065 0.0063
Echinococcus granulosus sodium and chloride dependent glycine 0.0019 0.0158 0.0158
Echinococcus granulosus neuropeptide receptor 0.0014 0.0065 0.0065
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0043 0.0615 1
Echinococcus multilocularis neuropeptides capa receptor 0.0014 0.0065 0.0065
Echinococcus granulosus protein kinase c eta type 0.0078 0.1253 0.1253
Brugia malayi Dopamine receptor 0.0014 0.0065 0.0063
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0123 0.2079 0.2211
Loa Loa (eye worm) hypothetical protein 0.0022 0.0217 0.0225
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.003 0.0026
Schistosoma mansoni atypical protein kinase C 0.0281 0.4984 0.5761
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0033 0.0028
Schistosoma mansoni adenoreceptor 0.0014 0.0065 0.0075
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0615 0.1243
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0099 0.1637 0.1739
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0185 0.3222 0.343
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0035 0.0451 0.2542
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0063
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0615 0.3479

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 8800 nM Inhibition of [3H]DA uptake at DAT in Sprague-Dawley rat striatum ChEMBL. 17489581
Inhibition (binding) = 22 % Displacement of [3H]citalopram from 5HTT in Sprague-Dawley rat cerebrum at 10 uM ChEMBL. 17489581
Inhibition (binding) = 36 % Displacement of [3H]nisoxetine from NET in Sprague-Dawley rat cortical tissue at 10 uM ChEMBL. 17489581
Ki (binding) = 6360 nM Displacement of [3H]WIN 35428 from DAT in Sprague-Dawley rat striatum ChEMBL. 17489581

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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