Detailed information for compound 1030102

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 505.49 | Formula: C24H26F3N5O4
  • H donors: 2 H acceptors: 3 LogP: 4.49 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1cc2nc(nc(c2cc1OC)N)N1CCC(CC1)CNC(=O)c1ccc(cc1)OC(F)(F)F
  • InChi: 1S/C24H26F3N5O4/c1-34-19-11-17-18(12-20(19)35-2)30-23(31-21(17)28)32-9-7-14(8-10-32)13-29-22(33)15-3-5-16(6-4-15)36-24(25,26)27/h3-6,11-12,14H,7-10,13H2,1-2H3,(H,29,33)(H2,28,30,31)
  • InChiKey: OAXLTZMILNBFGA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0198 0.2353 0.3617
Loa Loa (eye worm) hypothetical protein 0.0019 0.0054 0.0083
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0331 0.0509
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0331 0.0668
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0054 0.0071
Loa Loa (eye worm) nuclear hormone receptor 0.02 0.2385 0.3667
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0331 0.0509
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0167 0.0257
Trichomonas vaginalis glucosylceramidase, putative 0.052 0.6506 1
Echinococcus granulosus dna polymerase eta 0.002 0.0065 0.0087
Onchocerca volvulus 0.0028 0.0167 0.0273
Loa Loa (eye worm) hypothetical protein 0.0041 0.0331 0.0509
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0065 0.2101
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0065 0.2101
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0065 0.2101
Loa Loa (eye worm) hypothetical protein 0.0019 0.0054 0.0083
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0065 0.01
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0331 0.1686
Loa Loa (eye worm) hypothetical protein 0.0028 0.0167 0.0257
Brugia malayi conserved hypotetical protein 0.0019 0.0054 0.0083
Loa Loa (eye worm) hypothetical protein 0.0245 0.2968 0.4562
Echinococcus multilocularis dna polymerase kappa 0.002 0.0065 0.0059
Trichomonas vaginalis glucosylceramidase, putative 0.052 0.6506 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0452 0.0694
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0331 0.0509
Entamoeba histolytica hypothetical protein 0.0072 0.074 1
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0084 0.0129
Echinococcus multilocularis dna polymerase eta 0.002 0.0065 0.0059
Brugia malayi nuclear receptor RXR 0.0019 0.0054 0.0083
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0288 0.0347
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0098 0.1072 0.1649
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0065 0.2101
Brugia malayi beta-lactamase family protein 0.0037 0.0288 0.0443
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0054 0.0049
Brugia malayi Latrophilin receptor protein 2 0.0063 0.0613 0.0942
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0054 0.0049
Brugia malayi follicle stimulating hormone receptor 0.0234 0.2816 0.4328
Trichomonas vaginalis glucosylceramidase, putative 0.0341 0.4202 0.6424
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0054 0.0083
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0288 0.0347
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0331 0.0326
Loa Loa (eye worm) hypothetical protein 0.0022 0.0084 0.0129
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.1072 0.5524
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0065 0.2101
Schistosoma mansoni zinc finger protein 0.0019 0.0054 0.0252
Schistosoma mansoni hypothetical protein 0.0165 0.1937 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0054 0.0083
Loa Loa (eye worm) hypothetical protein 0.0063 0.0613 0.0942
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0331 0.1686
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0054 0.0049
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.052 0.6506 1
Mycobacterium tuberculosis Conserved protein 0.0037 0.0288 0.0983
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0288 0.0983
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.0613 0.0607
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0054 0.0071
Loa Loa (eye worm) hypothetical protein 0.0247 0.2985 0.4588
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0239 0.2882 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0288 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.0613 0.0607
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0331 0.0668
Schistosoma mansoni hypothetical protein 0.0135 0.1548 0.7984
Brugia malayi nuclear receptor NHR-88 0.0041 0.0331 0.0509
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0065 0.2101
Leishmania major DNA polymerase kappa, putative 0.002 0.0065 0.2101
Echinococcus multilocularis musashi 0.0028 0.0167 0.0162
Brugia malayi nuclear receptor NHR-67 0.0019 0.0054 0.0083
Trichomonas vaginalis glucosylceramidase, putative 0.036 0.4439 0.6791
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0331 0.1686
Loa Loa (eye worm) hypothetical protein 0.0027 0.0161 0.0247
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0065 0.2101
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0331 0.1686
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.0613 0.0942
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.074 0.107
Echinococcus granulosus survival motor neuron protein 1 0.0245 0.2968 0.4316
Loa Loa (eye worm) hypothetical protein 0.0019 0.0054 0.0083
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0331 0.0474
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.0054 0.0049
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0288 0.0983
Schistosoma mansoni DNA polymerase eta 0.002 0.0065 0.0307
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.0331 0.1686
Brugia malayi hypothetical protein 0.0072 0.074 0.1138
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0331 0.0326
Mycobacterium ulcerans lipase LipD 0.0037 0.0288 1
Loa Loa (eye worm) hypothetical protein 0.0202 0.2415 0.3712
Brugia malayi hypothetical protein 0.0019 0.0054 0.0083
Brugia malayi nuclear hormone receptor 0.0019 0.0054 0.0083
Loa Loa (eye worm) hypothetical protein 0.0022 0.0084 0.0129
Toxoplasma gondii ABC1 family protein 0.0037 0.0288 1
Schistosoma mansoni survival motor neuron protein 0.005 0.0452 0.231
Loa Loa (eye worm) beta-lactamase 0.0037 0.0288 0.0443
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0288 0.0983
Loa Loa (eye worm) hypothetical protein 0.0041 0.0331 0.0509
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0288 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0054 0.0083
Loa Loa (eye worm) hypothetical protein 0.0019 0.0054 0.0083
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0065 0.0206
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0331 0.0509
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0005 0.0008
Trichomonas vaginalis glucosylceramidase, putative 0.0341 0.4202 0.6424
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0065 0.2101
Brugia malayi ecdysone receptor 0.0019 0.0054 0.0083
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0084 0.0406
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.0331 0.0474
Echinococcus multilocularis neuropeptide s receptor 0.0548 0.687 0.6869
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0065 0.2101
Loa Loa (eye worm) hypothetical protein 0.0022 0.0084 0.0129
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0054 0.0252
Brugia malayi isocitrate dehydrogenase 0.0015 0.0005 0.0008
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0331 0.0668
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.1072 0.1554
Loa Loa (eye worm) DR-78 0.0019 0.0054 0.0083
Onchocerca volvulus 0.0037 0.0288 0.0564
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0098 0.1072 0.1649
Giardia lamblia DINP protein human, muc B family 0.002 0.0065 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0065 0.2101
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0331 0.0509
Schistosoma mansoni hypothetical protein 0.0063 0.0613 0.3143
Onchocerca volvulus Glucosylceramidase homolog 0.0341 0.4202 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0331 0.0509
Loa Loa (eye worm) hypothetical protein 0.0019 0.0054 0.0083
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0288 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0084 0.0129
Loa Loa (eye worm) hypothetical protein 0.0037 0.0288 0.0443
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0084 0.0406
Echinococcus multilocularis lamin dm0 0.0028 0.0167 0.0162
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.1072 0.1554
Leishmania major hypothetical protein, conserved 0.0037 0.0288 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0054 0.0071
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0288 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0331 0.1686
Loa Loa (eye worm) hypothetical protein 0.0198 0.2353 0.3617
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0054 0.0071
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0331 0.0509
Onchocerca volvulus 0.0037 0.0288 0.0564
Brugia malayi hypothetical protein 0.0245 0.2968 0.4562
Loa Loa (eye worm) hypothetical protein 0.0019 0.0054 0.0083
Entamoeba histolytica hypothetical protein 0.0072 0.074 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0331 0.0474
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0234 0.2816 0.4328
Echinococcus multilocularis geminin 0.0165 0.1937 0.1932
Entamoeba histolytica hypothetical protein 0.0072 0.074 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0054 0.0049
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0065 0.0307
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0065 0.2101
Schistosoma mansoni nuclear receptor 0.0019 0.0054 0.0252
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0331 0.0474
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0288 0.0983
Trichomonas vaginalis glucosylceramidase, putative 0.0341 0.4202 0.6424
Schistosoma mansoni hypothetical protein 0.0063 0.0613 0.3143
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0288 0.0443
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0054 0.0252
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0065 0.2101
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.0613 0.0884
Echinococcus granulosus GPCR family 2 0.0063 0.0613 0.0884
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0054 0.0252
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0288 0.0347
Echinococcus multilocularis GPCR, family 2 0.0063 0.0613 0.0607
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0331 0.1686
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.1072 0.1068
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0222 0.2662 0.387
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0054 0.0083
Brugia malayi hypothetical protein 0.0019 0.0054 0.0083
Mycobacterium tuberculosis Conserved protein 0.0037 0.0288 0.0983
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0084 0.0114
Loa Loa (eye worm) hypothetical protein 0.0019 0.0054 0.0083
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0054 0.0083
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0065 0.2101
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0065 0.2101
Brugia malayi hypothetical protein 0.0022 0.0084 0.0129
Brugia malayi MH2 domain containing protein 0.0116 0.1308 0.201
Trichomonas vaginalis glucosylceramidase, putative 0.036 0.4439 0.6791
Loa Loa (eye worm) hypothetical protein 0.0041 0.0331 0.0509
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0331 0.0509
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0084 0.0129
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0331 0.0509
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0331 0.0509
Loa Loa (eye worm) hypothetical protein 0.0019 0.0054 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0331 0.0509
Echinococcus granulosus geminin 0.0165 0.1937 0.2814
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0288 0.0347
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0065 0.0087
Mycobacterium tuberculosis Conserved protein 0.0037 0.0288 0.0983
Echinococcus granulosus intermediate filament protein 0.0028 0.0167 0.0236
Echinococcus granulosus lamin 0.0028 0.0167 0.0236
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0331 0.1686
Echinococcus multilocularis lamin 0.0028 0.0167 0.0162
Schistosoma mansoni lamin 0.0028 0.0167 0.0838
Onchocerca volvulus 0.005 0.0452 0.0958
Onchocerca volvulus Huntingtin homolog 0.0247 0.2985 0.7065
Schistosoma mansoni hypothetical protein 0.0072 0.074 0.3803
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0331 0.0474
Brugia malayi beta-lactamase 0.0037 0.0288 0.0443
Brugia malayi Calcitonin receptor-like protein seb-1 0.0198 0.2353 0.3617
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0331 0.0509
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1308 0.201
Loa Loa (eye worm) hypothetical protein 0.0247 0.2985 0.4588
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0065 0.2101
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0065 0.0206
Trichomonas vaginalis glucosylceramidase, putative 0.0341 0.4202 0.6424
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0331 0.1686
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.0613 0.0884
Loa Loa (eye worm) hypothetical protein 0.0041 0.0331 0.0509
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0288 0.0983
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0065 0.01
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0331 0.0509
Loa Loa (eye worm) hypothetical protein 0.0037 0.0288 0.0443
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0331 0.0509
Loa Loa (eye worm) hypothetical protein 0.0041 0.0331 0.0509
Mycobacterium leprae Probable lipase LipE 0.0037 0.0288 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.052 0.6506 1
Brugia malayi Steroid receptor seven-up type 2 0.0222 0.2662 0.4092
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0331 0.0509
Entamoeba histolytica hypothetical protein 0.0072 0.074 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0054 0.0083
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0005 0.0008
Onchocerca volvulus 0.0041 0.0331 0.0668
Loa Loa (eye worm) hypothetical protein 0.0135 0.1548 0.2379
Loa Loa (eye worm) hypothetical protein 0.0037 0.0288 0.0443
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0065 0.2101
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.074 0.0735
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0288 0.0983
Trichomonas vaginalis esterase, putative 0.0037 0.0288 0.0347
Schistosoma mansoni hypothetical protein 0.0063 0.0613 0.3143
Echinococcus granulosus neuropeptide s receptor 0.0548 0.687 1
Brugia malayi steroid hormone receptor 0.0041 0.0331 0.0509
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0288 0.1464
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0084 0.0129
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0288 0.0283
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0222 0.2662 0.2658
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0054 0.0071
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0331 0.0509
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0054 0.0083
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0054 0.0252
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0331 0.0474
Onchocerca volvulus 0.0037 0.0288 0.0564
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0054 0.0252
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0065 0.2101
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0065 0.2101
Loa Loa (eye worm) hypothetical protein 0.002 0.0065 0.01
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0054 0.0083
Brugia malayi latrophilin 2 splice variant baaae 0.0135 0.1548 0.2379
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0331 0.0326
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.0613 0.0942
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0198 0.2353 0.3617
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0331 0.0326
Schistosoma mansoni coup transcription factor 0.0041 0.0331 0.1686
Onchocerca volvulus Huntingtin homolog 0.0247 0.2985 0.7065
Schistosoma mansoni nuclear receptor 0.0019 0.0054 0.0252
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1308 0.201
Schistosoma mansoni hypothetical protein 0.005 0.0452 0.231
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0065 0.2101
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.052 0.6506 1
Trichomonas vaginalis glucosylceramidase, putative 0.0341 0.4202 0.6424
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0331 0.0509
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.1072 0.1068
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.1072 0.5524
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0054 0.0049
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0331 0.0326
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0331 0.0474
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0288 0.0443
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0331 0.0509
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0331 0.0509
Echinococcus multilocularis neuropeptide receptor A26 0.0548 0.687 0.6869
Echinococcus multilocularis thyroid hormone receptor alpha 0.0041 0.0331 0.0326
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0288 1
Brugia malayi ecdysteroid receptor 0.0041 0.0331 0.0509
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0331 0.1686
Echinococcus granulosus neuropeptide receptor A26 0.0548 0.687 1
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0288 0.0347
Trichomonas vaginalis glucosylceramidase, putative 0.0341 0.4202 0.6424
Leishmania major DNA polymerase eta, putative 0.002 0.0065 0.2101
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0331 0.0509
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0167 0.0257
Loa Loa (eye worm) hypothetical protein 0.0041 0.0331 0.0509
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0084 0.0078
Brugia malayi intermediate filament protein 0.0028 0.0167 0.0257
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0331 0.1686
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0331 0.0509
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0288 0.0412
Echinococcus granulosus lamin dm0 0.0028 0.0167 0.0236
Onchocerca volvulus 0.0028 0.0167 0.0273
Mycobacterium ulcerans hypothetical protein 0.0037 0.0288 1
Trichomonas vaginalis glucosylceramidase, putative 0.052 0.6506 1
Brugia malayi hypothetical protein 0.0247 0.2985 0.4588
Loa Loa (eye worm) hypothetical protein 0.0041 0.0331 0.0509
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0288 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0331 0.0474
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0288 0.5
Schistosoma mansoni lamin 0.0028 0.0167 0.0838
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0167 0.0257
Echinococcus granulosus dna polymerase kappa 0.002 0.0065 0.0087
Trichomonas vaginalis glucosylceramidase, putative 0.052 0.6506 1
Brugia malayi nuclear receptor NHR-88 0.0019 0.0054 0.0083
Trichomonas vaginalis glucosylceramidase, putative 0.0341 0.4202 0.6424
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0288 0.1464
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.074 0.3803
Schistosoma mansoni intermediate filament proteins 0.0028 0.0167 0.0838
Loa Loa (eye worm) hypothetical protein 0.0019 0.0054 0.0083
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0331 0.0509
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0054 0.0083
Loa Loa (eye worm) hypothetical protein 0.0037 0.0288 0.0443
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.1072 0.5524
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0065 0.0307
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0005 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0331 0.0326
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.0331 0.0509
Trypanosoma brucei unspecified product 0.002 0.0065 0.2101
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0288 0.0983
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0331 0.1686
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0054 0.0083
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0065 0.0059
Loa Loa (eye worm) hypothetical protein 0.0041 0.0331 0.0509
Echinococcus multilocularis survival motor neuron protein 1 0.0245 0.2968 0.2964
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0331 0.0326
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0065 0.2101
Brugia malayi tailless protein 0.0019 0.0054 0.0083
Mycobacterium ulcerans beta-lactamase 0.0037 0.0288 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0288 0.0443
Trichomonas vaginalis glucosylceramidase, putative 0.052 0.6506 1
Brugia malayi beta-lactamase family protein 0.0037 0.0288 0.0443
Loa Loa (eye worm) hypothetical protein 0.0037 0.0288 0.0443
Brugia malayi nuclear hormone receptor 0.0041 0.0331 0.0509
Brugia malayi nuclear receptor RXR 0.0022 0.0084 0.0129
Loa Loa (eye worm) hypothetical protein 0.0019 0.0054 0.0083
Schistosoma mansoni hypothetical protein 0.0063 0.0613 0.3143
Brugia malayi hypothetical protein 0.0022 0.0084 0.0129
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0054 0.0071
Loa Loa (eye worm) hypothetical protein 0.0019 0.0054 0.0083
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0065 0.01
Schistosoma mansoni hypothetical protein 0.0165 0.1937 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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