Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | estrogen receptor 1 | Starlite/ChEMBL | References |
Homo sapiens | estrogen receptor 2 (ER beta) | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | estrogen receptor 2 (ER beta) | 495 aa | 418 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0116 | 0 | 0.5 | |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0116 | 0 | 0.5 |
Onchocerca volvulus | 0.0116 | 0 | 0.5 | |
Onchocerca volvulus | 0.0116 | 0 | 0.5 | |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0148 | 1 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0148 | 1 | 0.5 |
Onchocerca volvulus | 0.0116 | 0 | 0.5 | |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0148 | 1 | 0.5 |
Onchocerca volvulus | 0.0116 | 0 | 0.5 | |
Onchocerca volvulus | 0.0116 | 0 | 0.5 | |
Onchocerca volvulus | 0.0116 | 0 | 0.5 | |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0148 | 1 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0148 | 1 | 0.5 |
Onchocerca volvulus | 0.0116 | 0 | 0.5 | |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0116 | 0 | 0.5 |
Onchocerca volvulus | 0.0116 | 0 | 0.5 | |
Onchocerca volvulus | 0.0116 | 0 | 0.5 | |
Onchocerca volvulus | 0.0116 | 0 | 0.5 | |
Trypanosoma brucei | protein kinase, putative | 0.0148 | 1 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0148 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0148 | 1 | 0.5 |
Onchocerca volvulus | 0.0116 | 0 | 0.5 | |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0148 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0148 | 1 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0148 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0148 | 1 | 1 |
Onchocerca volvulus | 0.0116 | 0 | 0.5 | |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0148 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0148 | 1 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0148 | 1 | 1 |
Onchocerca volvulus | 0.0116 | 0 | 0.5 | |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0148 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0148 | 1 | 0.5 |
Onchocerca volvulus | 0.0116 | 0 | 0.5 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.0148 | 1 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0148 | 1 | 0.5 |
Onchocerca volvulus | 0.0116 | 0 | 0.5 | |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0148 | 1 | 0.5 |
Onchocerca volvulus | 0.0116 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.006 mg kg-1 | In vivo inhibition of estrogen-stimulated uterine weight gain in immature rats on subcutaneous administration | ChEMBL. | 9154963 |
ED50 (functional) | = 0.25 mg kg-1 | In vivo inhibition of estrogen-stimulated uterine weight gain in immature rats on peroral administration | ChEMBL. | 9154963 |
IC50 (functional) | = 0.05 nM | Inhibition of 17-beta-estradiol (10e-11 M) mediated MCF-7 cell proliferation | ChEMBL. | 10328300 |
IC50 (functional) | = 0.05 nM | Inhibition of estrogen-induced proliferation in human MCF-7 breast cancer cells | ChEMBL. | 9154963 |
RBA (binding) | = 0.01 | Displacement of [3H]-17-beta-estradiol from estrogen receptor of MCF-7 cell lysate as relative binding affinity | ChEMBL. | 10328300 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 9154963 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.