Detailed information for compound 1030726

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 403.192 | Formula: C12H12N3Na2O8P
  • H donors: 4 H acceptors: 7 LogP: -2.82 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#C/C=C/c1cn([C@H]2C[C@@H]([C@H](O2)COP(=O)([O-])[O-])O)c(=O)[nH]c1=O.[Na+].[Na+]
  • InChi: 1S/C12H14N3O8P.2Na/c13-3-1-2-7-5-15(12(18)14-11(7)17)10-4-8(16)9(23-10)6-22-24(19,20)21;;/h1-2,5,8-10,16H,4,6H2,(H,14,17,18)(H2,19,20,21);;/q;2*+1/p-2/b2-1+;;/t8-,9+,10+;;/m0../s1
  • InChiKey: GKAALDYDRMBLGB-STCKJFIUSA-L  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mycobacterium tuberculosis Probable thymidylate synthase ThyX (ts) (TSase) References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Probable thymidylate synthase ThyX (ts) (TSase) Get druggable targets OG5_136913 All targets in OG5_136913
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYX (TS) (TSase) Get druggable targets OG5_136913 All targets in OG5_136913
Mycobacterium ulcerans FAD-dependent thymidylate synthase Get druggable targets OG5_136913 All targets in OG5_136913
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0001 0.0002
Brugia malayi CHE-14 protein 0.0047 0.015 0.0366
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0101 0.0649
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0036 0.004
Schistosoma mansoni aldehyde dehydrogenase 0.0315 0.1529 0.2135
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0763 0.3839 1
Brugia malayi ecdysteroid receptor 0.0034 0.0082 0.0189
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.01 0.042 0.1364
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0548 0.0766
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0082 0.0114
Schistosoma mansoni smad1 5 8 and 0.0025 0.0036 0.005
Echinococcus multilocularis traf and tnf receptor associated protein 0.002 0.001 0.0011
Loa Loa (eye worm) hypothetical protein 0.0047 0.0146 0.0377
Loa Loa (eye worm) hypothetical protein 0.008 0.0316 0.0821
Toxoplasma gondii HEAT repeat-containing protein 0.0063 0.0232 0.1467
Brugia malayi Latrophilin receptor protein 2 0.0097 0.0405 0.1033
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.016 0.367
Schistosoma mansoni alpha glucosidase 0.0038 0.0101 0.0141
Loa Loa (eye worm) hypothetical protein 0.0472 0.2337 0.6086
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0023 0.0023
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0316 0.102
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0101 0.0702
Schistosoma mansoni retinoic acid receptor RXR 0.0034 0.0082 0.0114
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0047 0.0146 0.0454
Brugia malayi hypothetical protein 0.0071 0.0273 0.0688
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.002 0.001 0.0021
Mycobacterium ulcerans beta-lactamase 0.008 0.0316 0.0316
Trichomonas vaginalis ap endonuclease, putative 0.01 0.042 0.2921
Loa Loa (eye worm) beta-lactamase 0.008 0.0316 0.0821
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0023 0.0045
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0082 0.0114
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0021
Mycobacterium leprae Probable lipase LipE 0.008 0.0316 0.0316
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1415 0.9846
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0086 0.0501
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0036 0.004
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1415 0.9846
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0082 0.0092
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0015 0.0122
Schistosoma mansoni Smad4 0.0025 0.0036 0.005
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0015 0.0013
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.0082 0.0114
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0091 0.027
Echinococcus granulosus histone lysine methyltransferase setb 0.0019 0.0001 0.0002
Brugia malayi Importin beta-1 subunit 0.0063 0.0232 0.0582
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.0082 0.0189
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0101 0.0113
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0143 0.0643 0.0643
Schistosoma mansoni ap endonuclease 0.01 0.042 0.0586
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.002 0.001 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.0082 0.021
Brugia malayi exodeoxyribonuclease III family protein 0.01 0.042 0.1071
Echinococcus granulosus GTP binding nuclear protein Ran 0.0047 0.0146 0.0204
Onchocerca volvulus 0.0081 0.0323 0.3783
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.0082 0.0114
Schistosoma mansoni hypothetical protein 0.0046 0.0141 0.0197
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0036 0.009
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.0015 0.0035
Schistosoma mansoni hypothetical protein 0.0097 0.0405 0.0565
Schistosoma mansoni hypothetical protein 0.0097 0.0405 0.0565
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0101 0.0303
Echinococcus granulosus lysosomal alpha glucosidase 0.0171 0.0785 0.1096
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0015 0.0016
Echinococcus multilocularis neuropeptide s receptor 0.0911 0.4599 0.5172
Echinococcus granulosus peregrin 0.0037 0.0098 0.0136
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0315 0.1529 0.5053
Echinococcus granulosus lysine specific demethylase 5A 0.0049 0.0158 0.0221
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0051 0.0171 0.1188
Mycobacterium tuberculosis Probable conserved lipoprotein 0.008 0.0316 0.0316
Loa Loa (eye worm) hypothetical protein 0.0069 0.0262 0.068
Mycobacterium ulcerans aldehyde dehydrogenase 0.0315 0.1529 0.1529
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.008 0.0316 0.0316
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0091 0.0534
Schistosoma mansoni alpha-glucosidase 0.0147 0.0662 0.0925
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0194 0.0905 0.2339
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0047 0.0146 0.3332
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0091 0.0102
Treponema pallidum fructose-bisphosphate aldolase 0.0293 0.1415 1
Schistosoma mansoni nocturnin 0.002 0.001 0.0013
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.016 0.0501
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.002 0.001 0.0066
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0156 0.0218
Schistosoma mansoni synaptojanin 0.002 0.001 0.0013
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.002 0.001 0.0021
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.01 0.042 0.1364
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0023 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0006 0.0038
Leishmania major importin beta-1 subunit, putative 0.0051 0.0171 0.0536
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1415 0.9846
Loa Loa (eye worm) hypothetical protein 0.0034 0.0082 0.021
Leishmania major hypothetical protein, conserved 0.008 0.0316 0.102
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0047 0.0146 0.0972
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.002 0.001 0.0011
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0015 0.0017
Schistosoma mansoni hypothetical protein 0.1408 0.7162 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0097 0.0405 0.1052
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0315 0.1529 0.1529
Trichomonas vaginalis penicillin-binding protein, putative 0.008 0.0316 0.2201
Loa Loa (eye worm) MH2 domain-containing protein 0.037 0.1814 0.4723
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0006 0.0038
Mycobacterium tuberculosis Probable hydrolase 0.008 0.0316 0.0316
Mycobacterium tuberculosis Conserved protein 0.008 0.0316 0.0316
Trypanosoma cruzi importin beta-1 subunit, putative 0.0051 0.0171 0.0536
Echinococcus multilocularis cpg binding protein 0.0092 0.0381 0.0428
Echinococcus multilocularis smad 0.0025 0.0036 0.004
Brugia malayi Bromodomain containing protein 0.0037 0.0098 0.023
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.002 0.001 0.0066
Schistosoma mansoni synaptojanin 0.002 0.001 0.0013
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.008 0.0316 0.0316
Brugia malayi glutaminase DH11.1 0.0297 0.1437 0.3728
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0091 0.0632
Schistosoma mansoni hypothetical protein 0.0097 0.0405 0.0565
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0091 0.027
Echinococcus multilocularis deoxyribonuclease 1 2 0.002 0.001 0.0011
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0548 0.0766
Mycobacterium ulcerans lipase LipD 0.008 0.0316 0.0316
Loa Loa (eye worm) hypothetical protein 0.046 0.2277 0.5929
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.0082 0.0092
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.008 0.0316 0.0801
Brugia malayi Niemann-Pick C1 protein precursor 0.011 0.0474 0.1214
Brugia malayi RNA binding protein 0.0125 0.0548 0.1407
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.0082 0.021
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0006 0.0038
Brugia malayi Calcitonin receptor-like protein seb-1 0.0306 0.1483 0.3849
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0316 0.102
Mycobacterium tuberculosis Probable exported protein 0.002 0.001 0.001
Schistosoma mansoni jumonji/arid domain-containing protein 0.0049 0.0158 0.0221
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0006 0.0038
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0006 0.0038
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0097 0.0405 0.1033
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0006 0.0038
Brugia malayi F/Y-rich N-terminus family protein 0.0039 0.0109 0.0259
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.01 0.042 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.01 0.042 0.2918
Schistosoma mansoni coup transcription factor 0.0034 0.0082 0.0114
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0091 0.2162
Brugia malayi beta-lactamase family protein 0.008 0.0316 0.0801
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.0082 0.0114
Loa Loa (eye worm) hypothetical protein 0.004 0.0111 0.0286
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0021
Trypanosoma brucei glucosidase, putative 0.0038 0.0101 0.0303
Schistosoma mansoni ran 0.0047 0.0146 0.0204
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0143 0.0643 0.0643
Brugia malayi Bromodomain containing protein 0.0078 0.0309 0.0782
Schistosoma mansoni patched 1 0.0047 0.015 0.0209
Echinococcus granulosus neuropeptide s receptor 0.0911 0.4599 0.6422
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.0082 0.0189
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1415 0.9846
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0023 0.009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.0082 0.021
Trypanosoma brucei importin beta-1 subunit, putative 0.0063 0.0232 0.0741
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.002 0.001 0.0066
Echinococcus multilocularis peregrin 0.0037 0.0098 0.011
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0006 0.0038
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0091 0.027
Loa Loa (eye worm) glutaminase 2 0.0297 0.1437 0.3742
Loa Loa (eye worm) jmjC domain-containing protein 0.0049 0.0158 0.0409
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0034
Echinococcus granulosus bloom syndrome protein 0.0021 0.0015 0.002
Onchocerca volvulus 0.0094 0.0389 0.4582
Schistosoma mansoni neutral sphingomyelinase 0.002 0.001 0.0013
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0015 0.002
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.0082 0.0114
Schistosoma mansoni cpg binding protein 0.0092 0.0381 0.0532
Echinococcus granulosus neutral sphingomyelinase 0.002 0.001 0.0013
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0006 0.0038
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.0323 0.0451
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0086 0.0501
Entamoeba histolytica hypothetical protein 0.0071 0.0273 0.1873
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.01 0.042 0.1364
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0101 0.0303
Brugia malayi steroid hormone receptor 0.0034 0.0082 0.0189
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0015 0.0013
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0604 0.3017 1
Schistosoma mansoni smad1 5 8 and 0.0025 0.0036 0.005
Echinococcus multilocularis zinc finger protein 0.0024 0.003 0.0033
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.002 0.001 0.0066
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1415 0.9846
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0036 0.005
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0015 0.0013
Schistosoma mansoni zinc finger protein 0.0024 0.003 0.0041
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.0082 0.0114
Trypanosoma brucei importin beta-1 subunit, putative 0.0063 0.0232 0.0741
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0101 0.0702
Echinococcus granulosus tar DNA binding protein 0.0125 0.0548 0.0766
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0023 0.0332
Loa Loa (eye worm) hypothetical protein 0.0034 0.0082 0.021
Mycobacterium ulcerans hypothetical protein 0.0318 0.1544 0.1544
Brugia malayi PHD-finger family protein 0.0035 0.0086 0.0199
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.01 0.042 0.1364
Toxoplasma gondii aldehyde dehydrogenase 0.0315 0.1529 1
Schistosoma mansoni importin beta-1 0.0063 0.0232 0.0325
Brugia malayi hypothetical protein 0.0032 0.007 0.0158
Brugia malayi MH2 domain containing protein 0.0025 0.0036 0.0069
Schistosoma mansoni cpg binding protein 0.0085 0.0346 0.0483
Echinococcus multilocularis importin subunit beta 1 0.0063 0.0232 0.0261
Schistosoma mansoni hypothetical protein 0.0094 0.0389 0.0544
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0036 0.005
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0082 0.0114
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0023 0.0023
Schistosoma mansoni ap endonuclease 0.01 0.042 0.0586
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0085 0.0343 0.111
Loa Loa (eye worm) RecQ helicase 0.0021 0.0015 0.0034
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0026 0.0042 0.0059
Loa Loa (eye worm) glutaminase 0.0297 0.1437 0.3742
Loa Loa (eye worm) hypothetical protein 0.0049 0.016 0.0414
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.0082 0.021
Schistosoma mansoni hypothetical protein 0.0401 0.1974 0.2757
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0015 0.0101
Giardia lamblia PHD finger protein 15 0.0035 0.0086 0.0542
Echinococcus granulosus geminin 0.1408 0.7162 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0006 0.0038
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0015 0.0033
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.01 0.042 0.109
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0085 0.0343 0.111
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0286 0.1378 0.4551
Loa Loa (eye worm) hypothetical protein 0.0035 0.0086 0.022
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.0082 0.0114
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0045 0.0062
Loa Loa (eye worm) CXXC zinc finger family protein 0.0085 0.0346 0.0898
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0094 0.0389 0.0992
Onchocerca volvulus 0.008 0.0316 0.3701
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.01 0.042 0.2918
Echinococcus granulosus traf and tnf receptor associated protein 0.002 0.001 0.0013
Echinococcus multilocularis Niemann Pick C1 protein 0.011 0.0474 0.0534
Brugia malayi Bromodomain containing protein 0.0037 0.0099 0.0233
Loa Loa (eye worm) hypothetical protein 0.0047 0.015 0.0387
Echinococcus granulosus dnaJ subfamily B 0.0401 0.1974 0.2757
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0156 0.0176
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.016 0.367
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0091 0.0127
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.0905 0.1264
Loa Loa (eye worm) hypothetical protein 0.0038 0.0099 0.0255
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0125 0.0548 0.1425
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0273 0.0381
Mycobacterium tuberculosis Conserved hypothetical protein 0.0318 0.1544 0.1544
Echinococcus granulosus expressed conserved protein 0.0104 0.044 0.0614
Brugia malayi MH2 domain containing protein 0.037 0.1814 0.4712
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0097 0.0405 0.0565
Echinococcus multilocularis protein dispatched 1 0.0054 0.0184 0.0207
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0082 0.0114
Leishmania major hypothetical protein, conserved 0.0049 0.016 0.0501
Brugia malayi PHD-finger family protein 0.0029 0.0056 0.0123
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0101 0.0141
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.0785 0.0882
Loa Loa (eye worm) RNA binding protein 0.0125 0.0548 0.1425
Trichomonas vaginalis penicillin-binding protein, putative 0.008 0.0316 0.2201
Mycobacterium leprae conserved hypothetical protein 0.008 0.0316 0.0316
Trichomonas vaginalis ap endonuclease, putative 0.01 0.042 0.2921
Schistosoma mansoni hypothetical protein 0.0046 0.0141 0.0197
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.0082 0.0189
Schistosoma mansoni hypothetical protein 0.0046 0.0141 0.0197
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0006 0.0038
Brugia malayi hypothetical protein 0.046 0.2277 0.5921
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0006 0.0038
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.008 0.0316 0.0442
Onchocerca volvulus Protein ultraspiracle homolog 0.0034 0.0082 0.0873
Mycobacterium tuberculosis Conserved protein 0.008 0.0316 0.0316
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0082 0.0114
Leishmania major mitochondrial DNA polymerase beta 0.0604 0.3017 1
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0086 0.022
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.002 0.001 0.0066
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0232 0.0324
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0071 0.0071
Echinococcus granulosus zinc finger protein 0.0024 0.003 0.0041
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0045 0.005
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.01 0.042 0.0586
Brugia malayi TAR-binding protein 0.0125 0.0548 0.1407
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.016 0.367
Onchocerca volvulus 0.008 0.0316 0.3701
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0604 0.3017 1
Onchocerca volvulus 0.008 0.0316 0.3701
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.0082 0.021
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0006 0.0038
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.0082 0.0114
Echinococcus granulosus Smad4 0.0025 0.0036 0.005
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.0082 0.0114
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.002 0.001 0.0066
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.01 0.042 0.042
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0021
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0023 0.0164
Leishmania major GTP-binding protein, putative 0.0047 0.0146 0.0454
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1415 0.9846
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0015 0.0016
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0015 0.0101
Schistosoma mansoni jumonji domain containing protein 0.0091 0.0374 0.0522
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0015 0.0033
Echinococcus multilocularis sterol regulatory element binding protein 0.0047 0.015 0.0169
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.0082 0.021
Plasmodium falciparum importin beta, putative 0.0063 0.0232 0.5434
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0082 0.0189
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.0323 0.0363
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0071 0.0071
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0047 0.0146 0.0164
Schistosoma mansoni hypothetical protein 0.0022 0.002 0.0028
Brugia malayi nuclear hormone receptor 0.0034 0.0082 0.0189
Echinococcus granulosus Protein patched homolog 1 0.0047 0.015 0.0209
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0262 0.1259 0.1757
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0316 0.2201
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0015 0.0101
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0509 0.2529 0.2529
Echinococcus granulosus Niemann Pick C1 protein 0.011 0.0474 0.0662
Echinococcus multilocularis protein patched 0.0047 0.015 0.0169
Trichomonas vaginalis helicase, putative 0.0019 0.0006 0.0038
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0015 0.0021
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0082 0.0189
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0082 0.0189
Mycobacterium tuberculosis Conserved protein 0.008 0.0316 0.0316
Loa Loa (eye worm) PHD-finger family protein 0.002 0.001 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0034 0.0082 0.021
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0021 0.0015 0.0017
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0091 0.027
Schistosoma mansoni hypothetical protein 0.002 0.001 0.0013
Brugia malayi Inositol-1 0.0036 0.0091 0.0212
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.0905 0.1264
Schistosoma mansoni hypothetical protein 0.0677 0.3393 0.4737
Onchocerca volvulus Alhambra homolog 0.0035 0.0086 0.0919
Echinococcus granulosus endonuclease exonuclease phosphatase 0.002 0.001 0.0013
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0306 0.1483 0.3862
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0087 0.0098
Giardia lamblia Fructose-bisphosphate aldolase 0.0293 0.1415 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0171 0.0785 0.2041
Loa Loa (eye worm) hypothetical protein 0.008 0.0316 0.0821
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0036 0.005
Mycobacterium tuberculosis Probable thymidylate synthase ThyX (ts) (TSase) 0.1958 1 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0034 0.0082 0.0092
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.0082 0.0092
Loa Loa (eye worm) hypothetical protein 0.0034 0.0082 0.021
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0015 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0006 0.0038
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0045 0.0062
Schistosoma mansoni hypothetical protein 0.0035 0.0086 0.012
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0015 0.0017
Onchocerca volvulus 0.0085 0.0346 0.4058
Schistosoma mansoni glutaminase 0.0297 0.1437 0.2007
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0194 0.0905 0.1264
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0015 0.002
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0047 0.0146 0.0899
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0082 0.0189
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0015 0.0017
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0103 0.0439 0.1428
Loa Loa (eye worm) hypothetical protein 0.0181 0.0838 0.2181
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0034 0.0082 0.0114
Brugia malayi jmjC domain containing protein 0.0049 0.0158 0.0389
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0548 0.0766
Plasmodium vivax hypothetical protein, conserved 0.008 0.0316 0.748
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0006 0.0038
Mycobacterium ulcerans esterase/lipase LipP 0.008 0.0316 0.0316
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.002 0.001 0.0066
Echinococcus multilocularis tar DNA binding protein 0.0125 0.0548 0.0617
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.011 0.0474 0.3308
Schistosoma mansoni jumonji/arid domain-containing protein 0.0049 0.0158 0.0221
Mycobacterium tuberculosis Probable lipase LipD 0.008 0.0316 0.0316
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0047 0.0146 0.0454
Loa Loa (eye worm) hypothetical protein 0.0034 0.0082 0.021
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0033 0.0074 0.0103
Trichomonas vaginalis esterase, putative 0.008 0.0316 0.2201
Echinococcus multilocularis neuropeptide receptor A26 0.0911 0.4599 0.5172
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.002 0.001 0.0013
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0082 0.0189
Onchocerca volvulus 0.0034 0.0082 0.0873
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0286 0.1378 0.4551
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0086 0.012
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0021
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0286 0.1378 0.4551
Schistosoma mansoni hypothetical protein 0.0097 0.0405 0.0565
Entamoeba histolytica hypothetical protein 0.0071 0.0273 0.1873
Loa Loa (eye worm) TAR-binding protein 0.0125 0.0548 0.1425
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.0082 0.0114
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0006 0.0038
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.002 0.0028
Echinococcus granulosus snurportin 1 0.0677 0.3393 0.4737
Schistosoma mansoni cpg binding protein 0.0092 0.0381 0.0532
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0315 0.1529 0.2135
Brugia malayi photoreceptor-specific nuclear receptor 0.0034 0.0082 0.0189
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.002 0.001 0.0021
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.01 0.042 0.0472
Loa Loa (eye worm) hypothetical protein 0.0034 0.0082 0.021
Echinococcus granulosus FTZ F1 alpha 0.0034 0.0082 0.0114
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0091 0.0632
Loa Loa (eye worm) hypothetical protein 0.008 0.0316 0.0821
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0604 0.3017 1
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.002 0.001 0.0011
Brugia malayi follicle stimulating hormone receptor 0.0763 0.3839 1
Schistosoma mansoni DNA helicase recq5 0.0021 0.0015 0.002
Trichomonas vaginalis Phospholipase C precursor, putative 0.002 0.001 0.0066
Schistosoma mansoni inositol monophosphatase 0.0036 0.0091 0.0127
Trichomonas vaginalis importin beta-1, putative 0.0051 0.0171 0.1188
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.002 0.001 0.0066
Plasmodium vivax importin-beta 2, putative 0.0063 0.0232 0.5434
Onchocerca volvulus 0.0181 0.0838 1
Echinococcus granulosus importin subunit beta 1 0.0063 0.0232 0.0325
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.0082 0.0189
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0047 0.0146 0.0454
Schistosoma mansoni inositol monophosphatase 0.0036 0.0091 0.0127
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0273 0.0307
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0101 0.0649
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0315 0.1529 0.1719
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0023 0.0023
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0091 0.0578
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0091 0.0632
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0047 0.0146 0.0357
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0082 0.0114
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0101 0.0702
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0112 0.0483 0.0675
Echinococcus multilocularis synaptojanin 1 0.002 0.001 0.0011
Loa Loa (eye worm) Smad1 0.0025 0.0036 0.009
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0023 0.0023
Echinococcus multilocularis lysine specific demethylase 5A 0.0042 0.0124 0.0139
Loa Loa (eye worm) hypothetical protein 0.0081 0.0323 0.0838
Schistosoma mansoni aldehyde dehydrogenase 0.0315 0.1529 0.2135
Trypanosoma brucei hypothetical protein, conserved 0.008 0.0316 0.102
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0006 0.0038
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1415 0.9846
Schistosoma mansoni hypothetical protein 0.002 0.001 0.0014
Loa Loa (eye worm) hypothetical protein 0.008 0.0316 0.0821
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.002 0.001 0.0013
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0026 0.0042 0.0047
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0086 0.012
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0273 0.0381
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0114 0.0495 0.0557
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.01 0.042 0.042
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.008 0.0316 0.0316
Echinococcus granulosus mixed lineage leukemia protein mll 0.0021 0.0015 0.0021
Brugia malayi Smad1 0.0025 0.0036 0.0069
Loa Loa (eye worm) inositol-1 0.0036 0.0091 0.0233
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0047 0.015 0.0387
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0015 0.0016
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0262 0.1259 0.1415
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0015 0.0035
Brugia malayi RNA, U transporter 1 0.018 0.0835 0.2155
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0101 0.0259
Loa Loa (eye worm) hypothetical protein 0.0209 0.0984 0.2561
Schistosoma mansoni DNA helicase recq1 0.0021 0.0015 0.002
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.002 0.001 0.0011
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.0323 0.0451
Loa Loa (eye worm) hypothetical protein 0.008 0.0316 0.0821
Loa Loa (eye worm) hypothetical protein 0.0034 0.0082 0.021
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0019 0.0001 0.0002
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.002 0.001 0.0021
Echinococcus granulosus GPCR family 2 0.0097 0.0405 0.0565
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0101 0.0303
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.0905 0.1264
Echinococcus granulosus beta LACTamase domain containing family member 0.008 0.0316 0.0442
Echinococcus multilocularis Smad4 0.0025 0.0036 0.004
Loa Loa (eye worm) hypothetical protein 0.0058 0.0205 0.053
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0114 0.0495 0.0691
Mycobacterium ulcerans aldehyde dehydrogenase 0.0315 0.1529 0.1529
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.008 0.0316 0.0442
Treponema pallidum hypothetical protein 0.002 0.001 0.0068
Echinococcus granulosus survival motor neuron protein 1 0.046 0.2277 0.3179
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0101 0.0238
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.0785 0.0882
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.0082 0.0189
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.0082 0.0114
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.016 0.0501
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.008 0.0316 0.0821
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.01 0.042 1
Loa Loa (eye worm) histone methyltransferase 0.0026 0.0042 0.0106
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0677 0.3393 0.8838
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0143 0.0643 0.0643
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0036 0.009
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0086 0.1858
Schistosoma mansoni survival motor neuron protein 0.0094 0.0389 0.0544
Echinococcus granulosus sterol regulatory element binding protein 0.0047 0.015 0.0209
Trichomonas vaginalis glutaminase, putative 0.0297 0.1437 1
Onchocerca volvulus 0.0099 0.0414 0.488
Loa Loa (eye worm) hypothetical protein 0.008 0.0316 0.0821
Schistosoma mansoni hypothetical protein 0.1408 0.7162 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0082 0.0092
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.016 0.0501
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0316 0.2201
Brugia malayi hypothetical protein 0.0181 0.0838 0.2165
Loa Loa (eye worm) hypothetical protein 0.0097 0.0405 0.1052
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.002 0.0022
Brugia malayi beta-lactamase 0.008 0.0316 0.0801
Onchocerca volvulus Bile acid receptor homolog 0.0034 0.0082 0.0873
Echinococcus granulosus Niemann Pick C1 protein 0.0158 0.0718 0.1003
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0047 0.0146 0.0377
Entamoeba histolytica hypothetical protein 0.0023 0.0023 0.0097
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0023 0.5
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0101 0.0702
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0293 0.1415 1
Brugia malayi hypothetical protein 0.0049 0.016 0.0393
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0194 0.0905 0.1264
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.0082 0.0189
Schistosoma mansoni cript-related 0.002 0.001 0.0013
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.0082 0.0114
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.002 0.001 0.0021
Loa Loa (eye worm) hypothetical protein 0.0063 0.0232 0.0602
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0015 0.0034
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0101 0.0702
Brugia malayi nuclear receptor NHR-88 0.0034 0.0082 0.0189
Echinococcus multilocularis expressed conserved protein 0.0104 0.044 0.0495
Plasmodium falciparum phd finger protein, putative 0.0035 0.0086 0.1858
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0101 0.0601
Loa Loa (eye worm) jmjC domain-containing protein 0.0072 0.0277 0.0719
Trichomonas vaginalis ran, putative 0.0047 0.0146 0.1017
Brugia malayi Glycosyl hydrolases family 31 protein 0.0171 0.0785 0.2024
Mycobacterium tuberculosis Probable lipase LipE 0.008 0.0316 0.0316
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0034 0.0082 0.0873
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.0082 0.0092
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0086 0.0096
Mycobacterium ulcerans aldehyde dehydrogenase 0.0315 0.1529 0.1529
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0293 0.1415 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0158 0.0718 0.0808
Entamoeba histolytica hypothetical protein 0.0051 0.0171 0.1146
Loa Loa (eye worm) hypothetical protein 0.006 0.0214 0.0555
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0181 0.0839 0.1172
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0023 0.0552
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0101 0.0702
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0085 0.0343 0.111
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1743 0.8892 1
Schistosoma mansoni smad1 5 8 and 0.0025 0.0036 0.005
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0023 0.0332
Echinococcus granulosus cpg binding protein 0.0092 0.0381 0.0532
Toxoplasma gondii histone lysine methyltransferase SET1 0.0164 0.0752 0.4884
Loa Loa (eye worm) hypothetical protein 0.0034 0.0082 0.021
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.0082 0.0114
Brugia malayi CXXC zinc finger family protein 0.0085 0.0346 0.0878
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.015 0.1043
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0015 0.0122
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0194 0.0905 0.1018
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1415 0.9846
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.016 0.0991
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0194 0.0905 0.1018
Treponema pallidum exodeoxyribonuclease (exoA) 0.01 0.042 0.2966
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0006 0.0038
Toxoplasma gondii ABC1 family protein 0.008 0.0316 0.2019
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.0082 0.0189
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.002 0.001 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.0082 0.0189
Toxoplasma gondii hypothetical protein 0.0097 0.0408 0.2619
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.0082 0.0092
Schistosoma mansoni alpha-glucosidase 0.0147 0.0662 0.0925
Mycobacterium ulcerans glutaminase 0.0297 0.1437 0.1437
Echinococcus multilocularis geminin 0.1408 0.7162 0.8054
Schistosoma mansoni hypothetical protein 0.0209 0.0984 0.1374
Mycobacterium tuberculosis Probable esterase LipL 0.008 0.0316 0.0316
Echinococcus multilocularis beta LACTamase domain containing family member 0.008 0.0316 0.0356
Echinococcus multilocularis snurportin 1 0.0677 0.3393 0.3816
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.0082 0.0092
Echinococcus granulosus neuropeptide receptor A26 0.0911 0.4599 0.6422
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0097 0.0405 0.0455
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0194 0.0905 0.2355
Schistosoma mansoni smad 0.0025 0.0036 0.005
Echinococcus multilocularis GPCR, family 2 0.0097 0.0405 0.0455
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0023 0.009
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0472 0.2337 0.6078
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0101 0.0702
Entamoeba histolytica hypothetical protein 0.0071 0.0273 0.1873
Echinococcus multilocularis neutral sphingomyelinase 0.002 0.001 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0082 0.0189
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0101 0.0702
Echinococcus granulosus synaptojanin 1 0.002 0.001 0.0013
Entamoeba histolytica hypothetical protein 0.0071 0.0273 0.1873
Brugia malayi jmjC domain containing protein 0.0114 0.0495 0.1268
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0316 0.2201
Mycobacterium ulcerans FAD-dependent thymidylate synthase 0.1958 1 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0047 0.0146 0.3332
Schistosoma mansoni bromodomain containing protein 0.0067 0.025 0.0349
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.01 0.042 1
Entamoeba histolytica Ran family GTPase 0.0047 0.0146 0.0972
Schistosoma mansoni hypothetical protein 0.0046 0.0141 0.0197
Mycobacterium ulcerans hypothetical protein 0.008 0.0316 0.0316
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0101 0.0702
Schistosoma mansoni hypothetical protein 0.0071 0.0273 0.0381
Schistosoma mansoni ran 0.0047 0.0146 0.0204
Echinococcus multilocularis dnaJ subfamily B 0.0401 0.1974 0.222
Brugia malayi MH1 domain containing protein 0.0025 0.0036 0.0069
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.0082 0.0092
Loa Loa (eye worm) hypothetical protein 0.011 0.0474 0.1233
Brugia malayi RNA recognition motif domain containing protein 0.0125 0.0548 0.1407
Loa Loa (eye worm) hypothetical protein 0.0034 0.0082 0.021
Brugia malayi latrophilin 2 splice variant baaae 0.0209 0.0984 0.2545
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0087 0.0121
Toxoplasma gondii exonuclease III APE 0.01 0.042 0.2699
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0082 0.0189
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0001 0.0002
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0548 0.0766
Loa Loa (eye worm) transcription factor SMAD2 0.037 0.1814 0.4723
Brugia malayi MH1 domain containing protein 0.0025 0.0036 0.0069
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0085 0.0343 0.111
Schistosoma mansoni carbon catabolite repressor protein 0.002 0.001 0.0013
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0548 0.0766
Echinococcus granulosus smad 0.0025 0.0036 0.005
Brugia malayi MH2 domain containing protein 0.0025 0.0036 0.0069
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0232 0.0261
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.0082 0.021
Echinococcus multilocularis survival motor neuron protein 1 0.046 0.2277 0.256
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.0323 0.0819
Brugia malayi beta-lactamase family protein 0.008 0.0316 0.0801
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0051 0.0171 0.1188

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 7.4 uM Inhibition of Mycobacterium tuberculosis ThyX-mediated dTMP synthesis using [5-3H]dUMP as substrate after 10 mins by liquid scintillation counting ChEMBL. 21657202
IC50 (binding) > 50 uM Inhibition of Mycobacterium tuberculosis His-tagged ThyA-mediated dTMP synthesis expressed in BL21 (DE3) Escherichia coli RbCl cells after 30 mins by photometric assay ChEMBL. 21657202
Inhibition (binding) = 8.8 % Inhibition of Mycobacterium tuberculosis His-tagged ThyA-mediated dTMP synthesis expressed in BL21 (DE3) Escherichia coli RbCl cells at 50 uM after 30 mins by photometric assay ChEMBL. 21657202
Inhibition (binding) = 81.3 % Inhibition of Mycobacterium tuberculosis ThyX-mediated dTMP synthesis using [5-3H]dUMP as substrate at 50 uM after 10 mins by liquid scintillation counting ChEMBL. 21657202

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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