Detailed information for compound 1030806

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 193.631 | Formula: C6H12ClN3O2
  • H donors: 2 H acceptors: 1 LogP: -0.69 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)C1CNC(=NC1)N.Cl
  • InChi: 1S/C6H11N3O2.ClH/c1-11-5(10)4-2-8-6(7)9-3-4;/h4H,2-3H2,1H3,(H3,7,8,9);1H
  • InChiKey: DSCQSUGSHLNSTF-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0019 0.0062 0.0117
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0018
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0059 0.0179
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0084 0.0159
Entamoeba histolytica hypothetical protein, conserved 0.0019 0.0062 0.0117
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0062 0.0189
Loa Loa (eye worm) hypothetical protein 0.0019 0.0059 0.0111
Echinococcus granulosus replication factor c subunit 1 0.001 0.0008 0.0019
Loa Loa (eye worm) oxidoreductase 0.0019 0.0062 0.0117
Loa Loa (eye worm) hypothetical protein 0.0019 0.0059 0.0111
Loa Loa (eye worm) hypothetical protein 0.0019 0.0059 0.0111
Echinococcus granulosus WW domain containing oxidoreductase 0.0019 0.0062 0.0144
Mycobacterium tuberculosis Possible oxidoreductase 0.0019 0.0062 0.0132
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0585 0.3304 0.6223
Loa Loa (eye worm) hypothetical protein 0.0039 0.0178 0.0336
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0935 0.5305 1
Loa Loa (eye worm) oxidoreductase 0.0019 0.0062 0.0117
Mycobacterium tuberculosis Probable oxidoreductase 0.0019 0.0062 0.0132
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0044 0.0069
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0191 0.1048 0.2415
Brugia malayi tailless protein 0.0019 0.0059 0.0111
Brugia malayi CXXC zinc finger family protein 0.0028 0.0114 0.0214
Schistosoma mansoni hypothetical protein 0.0015 0.0041 0.0125
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0122 0.0122
Leishmania major quinonoid dihydropteridine reductase 0.0019 0.0062 0.0034
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0008 0.0015
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0019 0.0062 0.0117
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.025 0.1386 0.1386
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0179 0.0337
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0048 0.0146
Onchocerca volvulus 0.025 0.1386 0.9053
Echinococcus multilocularis carbonyl reductase 1 0.0019 0.0062 0.0062
Plasmodium falciparum thioredoxin reductase 0.0017 0.0048 0.0288
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0059 0.0386
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0062 0.0102
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0162 0.0306
Brugia malayi conserved hypotetical protein 0.0019 0.0059 0.0111
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.0647 1
Plasmodium falciparum glutathione reductase 0.0048 0.0227 0.1587
Loa Loa (eye worm) hypothetical protein 0.0019 0.0059 0.0111
Schistosoma mansoni transcription factor LCR-F1 0.012 0.0639 0.1933
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0122 0.0369
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0179 0.0338
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0048 0.0075
Loa Loa (eye worm) glutamate receptor 0.0041 0.0186 0.0351
Loa Loa (eye worm) hypothetical protein 0.004 0.0179 0.0338
Loa Loa (eye worm) hypothetical protein 0.0039 0.0178 0.0336
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.012 0.0639 0.1472
Plasmodium vivax hypothetical protein, conserved 0.004 0.0179 0.1247
Brugia malayi nuclear receptor NHR-88 0.0039 0.0178 0.0336
Loa Loa (eye worm) hypothetical protein 0.0019 0.0059 0.0111
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0227 0.0522
Brugia malayi beta-lactamase 0.004 0.0179 0.0338
Mycobacterium ulcerans short-chain type oxidoreductase 0.0019 0.0062 0.0117
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0019 0.0062 0.0104
Echinococcus granulosus mitogen activated protein kinase 3 0.0585 0.3304 0.7613
Loa Loa (eye worm) hypothetical protein 0.0021 0.0072 0.0135
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0019 0.0062 0.0117
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0084 0.0144
Loa Loa (eye worm) hypothetical protein 0.0019 0.0059 0.0111
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.1048 0.3171
Schistosoma mansoni smad1 5 8 and 0.0017 0.0048 0.0146
Brugia malayi hypothetical protein 0.0024 0.0093 0.0175
Echinococcus granulosus dna polymerase kappa 0.0023 0.0084 0.0194
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0197 0.0197
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0059 0.0059
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0043 0.0067
Schistosoma mansoni hypothetical protein 0.0166 0.0901 0.2728
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0019 0.0062 0.0132
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0295 0.0555
Echinococcus multilocularis lamin dm0 0.0088 0.0457 0.0457
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0062 0.0189
Schistosoma mansoni DNA ligase IV 0.001 0.0008 0.0024
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0935 0.5305 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0084 0.0144
Mycobacterium ulcerans dehydrogenase 0.0019 0.0062 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.025 0.1386 0.2612
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0295 0.0627
Loa Loa (eye worm) glutamate receptor 0.0016 0.0045 0.0084
Loa Loa (eye worm) hypothetical protein 0.0039 0.0178 0.0336
Brugia malayi MH2 domain containing protein 0.0244 0.1351 0.2547
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0197 0.0371
Loa Loa (eye worm) beta-lactamase 0.004 0.0179 0.0338
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0062 0.0117
Loa Loa (eye worm) glutaminase 2 0.0324 0.181 0.3412
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0062 0.0117
Schistosoma mansoni patched 1 0.0041 0.0189 0.0573
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0048 0.0111
Schistosoma mansoni apoferritin-2 0.0008 0 0.0001
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0062 0.0117
Schistosoma mansoni carbonyl reductase 0.0019 0.0062 0.0189
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0048 0.0075
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0585 0.3304 0.6223
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0044 0.007
Mycobacterium ulcerans ketoacyl reductase 0.0019 0.0062 0.0117
Schistosoma mansoni DNA polymerase eta 0.0023 0.0084 0.0254
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0093 0.016
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.0577 0.1228
Brugia malayi hypothetical protein 0.0019 0.0059 0.0111
Echinococcus granulosus smad 0.0017 0.0048 0.0111
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0084 0.0144
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0162 0.0305
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0191 0.1048 0.1975
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0059 0.0386
Echinococcus granulosus carbonyl reductase 1 0.0019 0.0062 0.0144
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0043 0.0197 0.0595
Loa Loa (eye worm) transcription factor SMAD2 0.0244 0.1351 0.2547
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0019 0.0062 0.0102
Loa Loa (eye worm) hypothetical protein 0.0019 0.0059 0.0111
Loa Loa (eye worm) hypothetical protein 0.0041 0.0187 0.0352
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0093 0.0619
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0191 0.1048 0.2415
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0019 0.0062 0.0132
Brugia malayi steroid hormone receptor 0.0039 0.0178 0.0336
Onchocerca volvulus 0.0019 0.0062 0.0407
Onchocerca volvulus 0.001 0.0008 0.0053
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.025 0.1386 1
Loa Loa (eye worm) Smad1 0.0017 0.0048 0.0091
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0016 0.0016
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0048 0.0288
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0019 0.0062 0.0102
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0019 0.0062 0.0034
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0019 0.0062 0.0102
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0162 0.0291
Brugia malayi MH2 domain containing protein 0.0017 0.0048 0.0091
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0179 0.0338
Trichomonas vaginalis set domain proteins, putative 0.023 0.1269 0.2393
Echinococcus granulosus bloom syndrome protein 0.0019 0.0064 0.0147
Echinococcus granulosus nibrin 0.001 0.0008 0.0019
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0019 0.0062 0.0117
Schistosoma mansoni zinc finger protein 0.0019 0.0059 0.0179
Loa Loa (eye worm) hypothetical protein 0.0039 0.0178 0.0336
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.001 0.0029
Entamoeba histolytica hypothetical protein 0.025 0.1386 0.2612
Mycobacterium leprae conserved hypothetical protein 0.004 0.0179 0.2766
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0048 0.2925
Mycobacterium leprae Probable oxidoreductase 0.0019 0.0062 0.0957
Schistosoma mansoni smad1 5 8 and 0.0017 0.0048 0.0146
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0062 0.0117
Brugia malayi hypothetical protein 0.001 0.0008 0.0015
Echinococcus granulosus survival motor neuron protein 1 0.0766 0.434 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0048 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0048 0.0075
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0062 0.0117
Schistosoma mansoni carbonyl reductase 0.0019 0.0062 0.0189
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0044 0.0044
Schistosoma mansoni hypothetical protein 0.0011 0.0016 0.0047
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0039 0.0178 0.0178
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0019 0.0062 0.0102
Mycobacterium ulcerans hypothetical protein 0.0935 0.5305 1
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.025 0.1386 0.2602
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0048 0.0075
Loa Loa (eye worm) hypothetical protein 0.0019 0.0062 0.0117
Brugia malayi hypothetical protein 0.0021 0.0072 0.0135
Brugia malayi beta-lactamase family protein 0.004 0.0179 0.0338
Echinococcus granulosus metabotropic glutamate receptor 2 0.0034 0.0148 0.0342
Schistosoma mansoni hypothetical protein 0.012 0.0639 0.1933
Loa Loa (eye worm) hypothetical protein 0.0088 0.0457 0.0861
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0197 0.0356
Trypanosoma brucei short-chain dehydrogenase, putative 0.0019 0.0062 0.0102
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.001 0.0016
Onchocerca volvulus Bile acid receptor homolog 0.0039 0.0178 0.1163
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0072 0.0217
Echinococcus granulosus oxidoreductase 0.0019 0.0062 0.0144
Echinococcus granulosus GPCR family 2 0.0015 0.0041 0.0095
Trypanosoma brucei short-chain dehydrogenase, putative 0.0019 0.0062 0.0102
Brugia malayi Pre-SET motif family protein 0.0202 0.111 0.2092
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0585 0.3304 0.6229
Echinococcus multilocularis FTZ F1 alpha 0.0039 0.0178 0.0178
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0037 0.0164 0.031
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0039 0.0178 0.0539
Plasmodium vivax SET domain protein, putative 0.003 0.0122 0.0831
Entamoeba histolytica recQ family helicase, putative 0.0019 0.0064 0.012
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0019 0.0062 0.0132
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0062 0.0117
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0039 0.0178 0.041
Loa Loa (eye worm) hypothetical protein 0.0019 0.0062 0.0117
Onchocerca volvulus 0.0019 0.0062 0.0407
Brugia malayi glutathione reductase 0.0048 0.0227 0.0427
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0048 0.0101
Brugia malayi Retinol dehydrogenase 12 0.0019 0.0062 0.0117
Onchocerca volvulus 0.0039 0.0178 0.1163
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0062 0.0189
Loa Loa (eye worm) hypothetical protein 0.0766 0.434 0.8181
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0019 0.0062 0.0117
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0019 0.0062 0.0189
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0062 0.0117
Loa Loa (eye worm) glutaminase 0.0324 0.181 0.3412
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.025 0.1386 0.3193
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0162 0.0162
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0191 0.1048 0.1975
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0197 0.0371
Brugia malayi MH2 domain containing protein 0.0017 0.0048 0.0091
Plasmodium falciparum steroid dehydrogenase, putative 0.0019 0.0062 0.0394
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.001 0.0013 0.0024
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.0011
Leishmania major DNA polymerase eta, putative 0.0023 0.0084 0.0075
Onchocerca volvulus 0.003 0.0122 0.0797
Leishmania major hypothetical protein, conserved 0.0019 0.0062 0.0034
Schistosoma mansoni ap endonuclease 0.0037 0.0162 0.0492
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0084 0.0178
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0062 0.0117
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0585 0.3304 0.6197
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0062 0.0189
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0062 0.0117
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0019 0.0062 0.0117
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0059 0.0111
Echinococcus granulosus retinol dehydrogenase 11 0.0019 0.0062 0.0144
Leishmania major short chain dehydrogenase, putative 0.0019 0.0062 0.0034
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0062 0.0189
Mycobacterium ulcerans carveol-like dehydrogenase 0.0019 0.0062 0.0117
Leishmania major hypothetical protein, conserved 0.0024 0.0093 0.0092
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0062 0.0117
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0122 0.0122
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0062 0.0102
Mycobacterium tuberculosis Probable oxidoreductase 0.0019 0.0062 0.0132
Loa Loa (eye worm) hypothetical protein 0.0019 0.0059 0.0111
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0059 0.0059
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0019 0.0062 0.0117
Echinococcus multilocularis retinol dehydrogenase 11 0.0019 0.0062 0.0062
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0048 0.0075
Entamoeba histolytica hypothetical protein 0.0019 0.0062 0.0117
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0084 0.0254
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0084 0.0159
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0041 0.0078
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0122 0.0216
Echinococcus granulosus synaptic glycoprotein sc2 0.025 0.1386 0.3193
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0162 0.1125
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0044 0.0269
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0062 0.0189
Onchocerca volvulus Huntingtin homolog 0.0276 0.1531 1
Loa Loa (eye worm) nuclear factor I 0.0009 0.0006 0.0011
Schistosoma mansoni hypothetical protein 0.0015 0.0041 0.0125
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0008 0.0015
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0019 0.0062 0.0117
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0044 0.007
Leishmania major short chain dehydrogenase/reductase, putative 0.0019 0.0062 0.0034
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0062 0.0189
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0064 0.0147
Brugia malayi hypothetical protein 0.012 0.0639 0.1204
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.0577 0.1228
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0048 0.0075
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0048 0.0006
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0062 0.0117
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0015
Echinococcus multilocularis lamin 0.0088 0.0457 0.0457
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0039 0.0178 0.0336
Loa Loa (eye worm) hypothetical protein 0.0019 0.0062 0.0117
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0039 0.0178 0.041
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.0647 0.1377
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.1048 0.3171
Echinococcus granulosus ubiquitin specific protease 41 0.0043 0.0197 0.0453
Mycobacterium ulcerans short-chain dehydrogenase 0.0019 0.0062 0.0117
Schistosoma mansoni lamin 0.0088 0.0457 0.1382
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0039 0.0178 0.0539
Onchocerca volvulus 0.0019 0.0062 0.0407
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0585 0.3304 0.6223
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0019 0.0062 0.0957
Brugia malayi MH1 domain containing protein 0.0017 0.0048 0.0091
Schistosoma mansoni ferritin 0.0008 0 0.0001
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.0064 0.0169
Treponema pallidum NADH oxidase 0.0017 0.0048 0.2925
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0064 0.0147
Brugia malayi isocitrate dehydrogenase 0.0016 0.0044 0.0084
Trypanosoma brucei trypanothione reductase 0.0048 0.0227 0.0413
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0295 0.0295
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0227 0.0427
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.012 0.0639 0.0639
Brugia malayi Steroid receptor seven-up type 2 0.0039 0.0178 0.0336
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.001 0.0013 0.0024
Echinococcus multilocularis thyroid hormone receptor alpha 0.0039 0.0178 0.0178
Echinococcus multilocularis synaptic glycoprotein sc2 0.025 0.1386 0.1386
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0039 0.0178 0.0336
Trichomonas vaginalis CMGC family protein kinase 0.0585 0.3304 0.6229
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0019 0.0059 0.0111
Schistosoma mansoni DNA helicase recq1 0.0019 0.0064 0.0193
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0039 0.0178 0.0336
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0019 0.0062 0.0102
Leishmania major dehydrogenase-like protein 0.0019 0.0062 0.0034
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0232 0.0437
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0084 0.0159
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0062 0.0117
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0179 0.0413
Trypanosoma brucei unspecified product 0.0016 0.0043 0.0067
Loa Loa (eye worm) hypothetical protein 0.0019 0.0059 0.0111
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.001 0.0008 0.0118
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0227 0.1591
Brugia malayi hypothetical protein 0.001 0.0008 0.0015
Toxoplasma gondii oxidoreductase, putative 0.0019 0.0062 0.0104
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0041 0.0078
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0019 0.0062 0.0144
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0162 0.0306
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0179 0.0542
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0064 0.0105
Loa Loa (eye worm) oxidoreductase 0.0019 0.0062 0.0117
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0019 0.0062 0.0062
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0504 0.095
Echinococcus multilocularis dna polymerase eta 0.0023 0.0084 0.0084
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.074 0.1706
Brugia malayi MH1 domain containing protein 0.0009 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0042 0.0196 0.037
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0019 0.0062 0.0117
Onchocerca volvulus 0.0019 0.0059 0.0386
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0197 0.0356
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0062 0.0117
Loa Loa (eye worm) hypothetical protein 0.0021 0.0072 0.0135
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0093 0.0161
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0084 0.0144
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0062 0.0102
Schistosoma mansoni topbp1 0.001 0.0008 0.0024
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0019 0.0062 0.0132
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0064 0.0037
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0122 0.0281
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0048 0.0075
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0048 0.0121
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0008 0.0015
Brugia malayi Thioredoxin reductase 0.0048 0.0227 0.0427
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0059 0.0111
Loa Loa (eye worm) hypothetical protein 0.0019 0.0059 0.0111
Mycobacterium ulcerans oxidoreductase 0.0019 0.0062 0.0117
Brugia malayi beta-lactamase family protein 0.004 0.0179 0.0338
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0162 0.0306
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0048 0.0075
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0048 0.0111
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0044 0.0069
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0019 0.0062 0.0132
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0019 0.0062 0.0102
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.025 0.1386 1
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0019 0.0062 0.0102
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0048 0.0288
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0019 0.0062 0.0132
Schistosoma mansoni cpg binding protein 0.0028 0.0114 0.0344
Echinococcus granulosus carbonyl reductase 1 0.0019 0.0062 0.0144
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0039 0.0178 0.0178
Brugia malayi nuclear hormone receptor 0.0019 0.0059 0.0111
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.001 0.0004
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0044 0.0264
Mycobacterium ulcerans hypothetical protein 0.004 0.0179 0.0337
Leishmania major short chain dehydrogenase, putative 0.0019 0.0062 0.0034
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0264 0.0484
Onchocerca volvulus Sepiapterin reductase homolog 0.0019 0.0062 0.0407
Leishmania major quinonoid dihydropteridine reductase 0.0019 0.0062 0.0034
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0008 0.0015
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0044 0.0044
Schistosoma mansoni carbonyl reductase 0.0019 0.0062 0.0189
Loa Loa (eye worm) hypothetical protein 0.0276 0.1531 0.2885
Loa Loa (eye worm) oxidoreductase 0.0019 0.0062 0.0117
Leishmania major hypothetical protein, conserved 0.0019 0.0062 0.0034
Schistosoma mansoni metabotropic glutamate receptor 0.0034 0.0148 0.0449
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0935 0.5305 1
Entamoeba histolytica short chain dehydrogenase family protein 0.0019 0.0062 0.0117
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0041 0.0078
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0008 0.0024
Leishmania major DNA polymerase kappa, putative 0.0023 0.0084 0.0075
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0059 0.0059
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0019 0.0062 0.0132
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0062 0.0189
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0048 0.0076
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0084 0.0144
Schistosoma mansoni lamin 0.0088 0.0457 0.1382
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0179 0.0542
Schistosoma mansoni hypothetical protein 0.04 0.2242 0.6786
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0084 0.0158
Brugia malayi Pre-SET motif family protein 0.003 0.0122 0.023
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0019 0.0062 0.0189
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0062 0.0189
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0019 0.0062 0.0132
Echinococcus granulosus intermediate filament protein 0.0088 0.0457 0.1052
Plasmodium falciparum thioredoxin reductase 0.0048 0.0227 0.1587
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0019 0.0062 0.0117
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0062 0.0117
Mycobacterium ulcerans short-chain dehydrogenase 0.0019 0.0062 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0008 0.0015
Echinococcus multilocularis ecdysone induced protein 78C 0.0039 0.0178 0.0178
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0048 0.0006
Leishmania major quinonoid dihydropteridine reductase 0.0019 0.0062 0.0034
Brugia malayi Metabotropic glutamate receptor precursor. 0.0041 0.0186 0.0351
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0062 0.0189
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0062 0.0189
Echinococcus multilocularis musashi 0.0088 0.0457 0.0457
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0162 0.1121
Trypanosoma cruzi short chain dehydrogenase, putative 0.0019 0.0062 0.0102
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0585 0.3304 0.6223
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0197 0.0356
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0084 0.0144
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0059 0.0059
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0062 0.0189
Plasmodium falciparum polyprenol reductase, putative 0.025 0.1386 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0162 1
Plasmodium vivax replication factor C subunit 1, putative 0.001 0.0008 0.0005
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0179 0.0381
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0062 0.0117
Leishmania major oxidoreductase-like protein 0.0019 0.0062 0.0034
Echinococcus granulosus retinol dehydrogenase 11 0.0019 0.0062 0.0144
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0062 0.0117
Mycobacterium ulcerans short-chain dehydrogenase 0.0019 0.0062 0.0117
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0019 0.0062 0.0132
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0062 0.0117
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0019 0.0062 0.0117
Loa Loa (eye worm) hypothetical protein 0.004 0.0179 0.0338
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0122 0.0369
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0019 0.0062 0.0062
Brugia malayi CHE-14 protein 0.0041 0.0189 0.0357
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.001 0.0008 0.0014
Schistosoma mansoni steroid hormone receptor ad4bp 0.0039 0.0178 0.0539
Trypanosoma cruzi short chain dehydrogenase, putative 0.0019 0.0062 0.0102
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0935 0.5305 1
Echinococcus multilocularis dnaJ subfamily B 0.04 0.2242 0.2242
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0062 0.0104
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0048 0.0145
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.0008 0.0001
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0008 0.0015
Loa Loa (eye worm) hypothetical protein 0.0096 0.0504 0.095
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0084 0.0159
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0041 0.0095
Echinococcus multilocularis steroid dehydrogenase 0.0019 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0019 0.0062 0.0117
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0062 0.0117
Mycobacterium tuberculosis Probable dehydrogenase 0.0019 0.0062 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0039 0.0178 0.0336
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0062 0.0189
Mycobacterium tuberculosis Conserved protein 0.004 0.0179 0.0381
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0019 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0019 0.0059 0.0111
Loa Loa (eye worm) oxidoreductase 0.0019 0.0062 0.0117
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0179 0.0381
Loa Loa (eye worm) hypothetical protein 0.0024 0.0093 0.0175
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0019 0.0062 0.0117
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0179 0.0381
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0179 0.0337
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0019 0.0062 0.0117
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0015
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0039 0.0178 0.0539
Echinococcus multilocularis transient receptor potential cation channel 0.0019 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0019 0.0062 0.0117
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0179 0.0323
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0062 0.0117
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0078
Echinococcus multilocularis smad 0.0017 0.0048 0.0048
Loa Loa (eye worm) glutathione reductase 0.0048 0.0227 0.0427
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0043 0.0197 0.0371
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0019 0.0062 0.0132
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0048 0.0089
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0093 0.016
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0062 0.0117
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0019 0.0062 0.0117
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0048 0.0075
Echinococcus multilocularis retinol dehydrogenase 11 0.0019 0.0062 0.0062
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.025 0.1386 0.2601
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0189 0.0357
Echinococcus multilocularis Smad4 0.0017 0.0048 0.0048
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0162 0.0374
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.0072 0.0166
Loa Loa (eye worm) oxidoreductase 0.0019 0.0062 0.0117
Brugia malayi ecdysone receptor 0.0019 0.0059 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0039 0.0178 0.0336
Schistosoma mansoni DNA helicase recq5 0.0019 0.0064 0.0193
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0072 0.0217
Schistosoma mansoni peptidase 0.0012 0.002 0.0061
Brugia malayi DKFZp564C0469 protein 0.001 0.0008 0.0015
Echinococcus granulosus expressed conserved protein 0.009 0.0471 0.1084
Loa Loa (eye worm) histone methyltransferase 0.001 0.0009 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0084 0.0144
Onchocerca volvulus 0.0156 0.0848 0.5539
Schistosoma mansoni ferritin light chain 0.0008 0 0.0001
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0019 0.0062 0.0394
Brugia malayi hypothetical protein 0.0019 0.0062 0.0117
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0062 0.0117
Echinococcus multilocularis oxidoreductase 0.0019 0.0062 0.0062
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0019 0.0062 0.0117
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0039 0.0178 0.0336
Mycobacterium tuberculosis Conserved protein 0.004 0.0179 0.0381
Loa Loa (eye worm) hypothetical protein 0.0039 0.0178 0.0336
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0044 0.0069
Toxoplasma gondii thioredoxin reductase 0.0048 0.0227 0.0414
Schistosoma mansoni thyroid hormone receptor 0.0039 0.0178 0.0539
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0084 0.0144
Schistosoma mansoni coup transcription factor 0.0039 0.0178 0.0539
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.0072 0.0135
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.03 0.0908
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0062 0.0189
Leishmania major short chain dehydrogenase/reductase, putative 0.0019 0.0062 0.0034
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0935 0.5305 1
Brugia malayi Receptor family ligand binding region containing protein 0.001 0.0013 0.0024
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0059 0.0059
Trichomonas vaginalis glutaminase, putative 0.0324 0.181 0.3412
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0179 0.0179
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0019 0.0062 0.0062
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.001 0.0003
Onchocerca volvulus 0.0019 0.0062 0.0407
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0048 0.0006
Schistosoma mansoni glutaminase 0.0324 0.181 0.5479
Loa Loa (eye worm) hypothetical protein 0.0041 0.0189 0.0357
Mycobacterium ulcerans oxidoreductase 0.0019 0.0062 0.0117
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.025 0.1386 0.2612
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0044 0.0084
Schistosoma mansoni Smad4 0.0017 0.0048 0.0146
Trichomonas vaginalis ferritin, putative 0.0008 0 0.0001
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0019 0.0062 0.0102
Entamoeba histolytica recQ family DNA helicase 0.001 0.001 0.0018
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0008 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0008 0.0015
Onchocerca volvulus 0.0019 0.0062 0.0407
Onchocerca volvulus 0.0019 0.0062 0.0407
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0084 0.0144
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0008 0.0001
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0044 0.0094
Schistosoma mansoni ferritin 0.0008 0 0.0001
Echinococcus granulosus geminin 0.0166 0.0901 0.2077
Brugia malayi Intermediate filament tail domain containing protein 0.0088 0.0457 0.0861
Plasmodium falciparum glutathione reductase 0.0017 0.0048 0.0288
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0295 0.0555
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0084 0.0144
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0048 0.0294
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0191 0.1048 0.1048
Loa Loa (eye worm) hypothetical protein 0.0276 0.1531 0.2885
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.025 0.1386 0.2612
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0062 0.0117
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0935 0.5305 1
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0046 0.0218 0.066
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0227 0.0227
Mycobacterium ulcerans short chain dehydrogenase 0.0829 0.4696 0.8854
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0062 0.0104
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0019 0.0062 0.0117
Schistosoma mansoni smad 0.0017 0.0048 0.0146
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0084 0.0144
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0062 0.0117
Loa Loa (eye worm) hypothetical protein 0.0935 0.5305 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0295 0.0679
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0019 0.0062 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.025 0.1386 0.2612
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0019 0.0062 0.0394
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0295 0.0892
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0019 0.0062 0.0132
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0232 0.0437
Echinococcus multilocularis metabotropic glutamate receptor 5 0.005 0.024 0.024
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0019 0.0062 0.0132
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0015
Brugia malayi nuclear hormone receptor 0.0039 0.0178 0.0336
Leishmania major trypanothione reductase 0.0048 0.0227 0.0346
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0048 0.0048
Echinococcus multilocularis carbonyl reductase 1 0.0019 0.0062 0.0062
Plasmodium vivax polyprenol reductase, putative 0.025 0.1386 1
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0059 0.0136
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.0577 0.8922
Brugia malayi dehydrogenases, short chain protein 9 0.0019 0.0062 0.0117
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0189 0.0436
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0084 0.0144
Schistosoma mansoni cpg binding protein 0.003 0.0123 0.0372
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.025 0.1386 0.2612
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0504 0.0504
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0062 0.0189
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.001 0.0008 0.0472
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0041 0.0095
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0084 0.0194
Loa Loa (eye worm) hypothetical protein 0.0021 0.0072 0.0135
Trichomonas vaginalis CMGC family protein kinase 0.0585 0.3304 0.6229
Treponema pallidum ATP-dependent DNA helicase 0.001 0.001 0.0561
Schistosoma mansoni nuclear receptor 0.0019 0.0059 0.0179
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0019 0.0062 0.0102
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0064 0.0405
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0019 0.0062 0.0132
Brugia malayi MAP kinase sur-1 0.0585 0.3304 0.6229
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0227 0.0413
Mycobacterium leprae Probable lipase LipE 0.004 0.0179 0.2766
Schistosoma mansoni topbp1 0.001 0.0008 0.0024
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0044 0.0069
Loa Loa (eye worm) oxidoreductase 0.0019 0.0062 0.0117
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0039 0.0178 0.041
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0062 0.0117
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0093 0.0614
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0179 0.0338
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0062 0.0102
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0197 0.0453
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0935 0.5305 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0039 0.0178 0.0336
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0019 0.0062 0.0117
Schistosoma mansoni intermediate filament proteins 0.0088 0.0457 0.1382
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0019 0.0062 0.0117
Schistosoma mansoni thyroid hormone receptor 0.0039 0.0178 0.0539
Loa Loa (eye worm) hypothetical protein 0.0039 0.0178 0.0336
Echinococcus multilocularis bloom syndrome protein 0.0019 0.0064 0.0064
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0048 0.0048
Onchocerca volvulus 0.0019 0.0062 0.0407
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0062 0.0189
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0039 0.0178 0.0336
Entamoeba histolytica hypothetical protein 0.012 0.0639 0.1204
Toxoplasma gondii oxidoreductase, putative 0.0019 0.0062 0.0104
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.074 0.074
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0044 0.0044
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0179 0.0381
Toxoplasma gondii carbonyl reductase 1, putative 0.0019 0.0062 0.0104
Plasmodium vivax steroid dehydrogenase, putative 0.0019 0.0062 0.0399
Brugia malayi intermediate filament protein 0.0088 0.0457 0.0861
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0072 0.0135
Brugia malayi hypothetical protein 0.0766 0.434 0.8181
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0009 0.0009
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0162 0.0306
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0039 0.0178 0.0336
Brugia malayi hypothetical protein 0.0276 0.1531 0.2885
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0197 0.0371
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0008 0.0015
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0064 0.0107
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0019 0.0062 0.0104
Mycobacterium ulcerans lipase LipD 0.004 0.0179 0.0337
Leishmania major quinonoid dihydropteridine reductase 0.0019 0.0062 0.0034
Plasmodium vivax glutathione reductase, putative 0.0048 0.0227 0.1591
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0019 0.0062 0.0102
Echinococcus multilocularis ubiquitin specific protease 41 0.0043 0.0197 0.0197
Brugia malayi Dehydrogenases, short chain protein 2 0.0019 0.0062 0.0117
Schistosoma mansoni cpg binding protein 0.003 0.0123 0.0372
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0019 0.0062 0.0117
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0019 0.0062 0.0102
Onchocerca volvulus 0.0019 0.0062 0.0407
Echinococcus multilocularis steroid dehydrogenase 0.0019 0.0062 0.0062
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0019 0.0062 0.0104
Brugia malayi nuclear receptor RXR 0.0021 0.0072 0.0135
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0008 0.0008
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0048 0.0091
Entamoeba histolytica hypothetical protein 0.012 0.0639 0.1204
Trypanosoma brucei unspecified product 0.0016 0.0043 0.0067
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0059 0.0136
Echinococcus granulosus carbonyl reductase 1 0.0019 0.0062 0.0144
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0039 0.0178 0.0178
Brugia malayi dehydrogenases, short chain protein 2 0.0019 0.0062 0.0117
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0179 0.0338
Leishmania major quinonoid dihydropteridine reductase 0.0019 0.0062 0.0034
Schistosoma mansoni hypothetical protein 0.0015 0.0041 0.0125
Echinococcus granulosus ecdysone induced protein 78C 0.0039 0.0178 0.041
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0019 0.0062 0.0957
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0039 0.0178 0.0336
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0018
Toxoplasma gondii exonuclease III APE 0.0037 0.0162 0.0293
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0179 0.0323
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0019 0.0062 0.0957
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.111 0.2092
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0039 0.0178 0.0539
Loa Loa (eye worm) hypothetical protein 0.0019 0.0062 0.0117
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0042 0.0196 0.0196
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0084 0.0178
Brugia malayi glutaminase DH11.1 0.0324 0.181 0.3412
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0019 0.0062 0.0117
Schistosoma mansoni synaptic glycoprotein sc2 related 0.025 0.1386 0.4194
Loa Loa (eye worm) hypothetical protein 0.004 0.0179 0.0338
Brugia malayi Smad1 0.0017 0.0048 0.0091
Trichomonas vaginalis esterase, putative 0.004 0.0179 0.0338
Echinococcus multilocularis conserved hypothetical protein 0.0019 0.0062 0.0062
Loa Loa (eye worm) MH2 domain-containing protein 0.0244 0.1351 0.2547
Loa Loa (eye worm) hypothetical protein 0.0019 0.0062 0.0117
Onchocerca volvulus 0.0088 0.0457 0.2983
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0019 0.0062 0.0407
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0019 0.0062 0.0957
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0044 0.0084
Mycobacterium tuberculosis Probable oxidoreductase 0.0019 0.0062 0.0132
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.0178 0.041
Onchocerca volvulus 0.004 0.0179 0.1171
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.025 0.1386 0.2612
Schistosoma mansoni hypothetical protein 0.0033 0.0144 0.0435
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0059 0.0179
Brugia malayi MH1 domain containing protein 0.0009 0.0006 0.0011
Entamoeba histolytica recQ family helicase, putative 0.0009 0.0007 0.0014
Loa Loa (eye worm) hypothetical protein 0.004 0.0179 0.0338
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0062 0.0102
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0019 0.0062 0.0144
Schistosoma mansoni hypothetical protein 0.004 0.0181 0.0547
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0019 0.0062 0.0189
Onchocerca volvulus 0.0028 0.0114 0.0743
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0062 0.0104
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0064 0.0064
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0039 0.0178 0.0539
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0064 0.012
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0039 0.0178 0.0178
Mycobacterium ulcerans ketoacyl reductase 0.0019 0.0062 0.0117
Leishmania major hypothetical protein, conserved 0.004 0.0179 0.0256
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.0059 0.0059
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0295 0.0476
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0024
Schistosoma mansoni hypothetical protein 0.0156 0.0848 0.2566
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0015
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0048 0.0075
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0084 0.0144
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0064 0.0105
Mycobacterium ulcerans ketoacyl reductase 0.0019 0.0062 0.0117
Schistosoma mansoni nuclear receptor 0.0019 0.0059 0.0179
Trichomonas vaginalis steroid dehydrogenase, putative 0.0019 0.0062 0.0117
Brugia malayi topoisomerase 0.001 0.0008 0.0015
Loa Loa (eye worm) hypothetical protein 0.005 0.024 0.0453
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0062 0.0189
Echinococcus granulosus dnaJ subfamily B 0.04 0.2242 0.5166
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0112 0.0259
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0088 0.0457 0.0861
Giardia lamblia DINP protein human, muc B family 0.0023 0.0084 0.0231
Echinococcus granulosus Smad4 0.0017 0.0048 0.0111
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0019 0.0062 0.0117
Echinococcus multilocularis GPCR, family 2 0.0015 0.0041 0.0041
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0084 0.0159
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0064 0.0064
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0043 0.0197 0.0572
Echinococcus multilocularis survival motor neuron protein 1 0.0766 0.434 0.434
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0019 0.0062 0.0102
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0048 0.0089
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0062 0.0117
Loa Loa (eye worm) hypothetical protein 0.0043 0.0197 0.0371
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0062 0.0117
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0059 0.0179
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0019 0.0062 0.0117
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0048 0.009
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0039 0.0178 0.0336
Giardia lamblia Synaptic glycoprotein SC2 0.025 0.1386 0.4179
Leishmania major pteridine reductase 1 0.0019 0.0062 0.0034
Echinococcus multilocularis nibrin 0.001 0.0008 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0039 0.0178 0.0336
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0019 0.0062 0.0132
Schistosoma mansoni ferritin 0.0008 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0062 0.0117
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0044 0.0134
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0039 0.0178 0.0336
Entamoeba histolytica hypothetical protein 0.012 0.0639 0.1204
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0019 0.0062 0.0407
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0019 0.0062 0.0102
Brugia malayi metabotropic glutamate receptor type 2 0.002 0.0067 0.0126
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0059 0.0111
Schistosoma mansoni ferritin 0.0008 0 0.0001
Echinococcus multilocularis mitogen activated protein kinase 0.0585 0.3304 0.3304
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.025 0.1386 0.2612
Schistosoma mansoni ap endonuclease 0.0037 0.0162 0.0492
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0048 0.0091
Brugia malayi oxidoreductase 0.0019 0.0062 0.0117
Mycobacterium ulcerans dehydrogenase/reductase 0.0019 0.0062 0.0117
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0935 0.5305 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0084 0.0144
Giardia lamblia Reductase, putative 0.0019 0.0062 0.0165
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0059 0.0111
Leishmania major quinonoid dihydropteridine reductase 0.0019 0.0062 0.0034
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0093 0.0614
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0039 0.0178 0.0336
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.025 0.1386 0.2612
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0043 0.0067
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0043 0.0197 0.0595
Mycobacterium ulcerans short-chain dehydrogenase 0.0019 0.0062 0.0117
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0044 0.0044
Leishmania major hypothetical protein, conserved 0.0019 0.0062 0.0034
Echinococcus granulosus carbonyl reductase 1 0.0019 0.0062 0.0144
Entamoeba histolytica hypothetical protein 0.012 0.0639 0.1204
Schistosoma mansoni RAR-like nuclear receptor 0.0039 0.0178 0.0539
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0114 0.0214
Echinococcus multilocularis protein patched 0.0041 0.0189 0.0189
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0041 0.0041
Leishmania major 3-keto-dihydrosphingosine reductase 0.0019 0.0062 0.0034
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0039 0.0178 0.1163
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0019 0.0062 0.0165
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0062 0.0102
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0059 0.0111
Brugia malayi cytoplasmic intermediate filament protein 0.0047 0.0223 0.042
Brugia malayi ecdysteroid receptor 0.0039 0.0178 0.0336
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0039 0.0178 0.0336
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0019 0.0062 0.0189
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0197 0.0453
Schistosoma mansoni retinal dehydrogenase 0.0019 0.0062 0.0189
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0019 0.0062 0.0102
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0935 0.5305 1
Loa Loa (eye worm) oxidoreductase 0.0019 0.0062 0.0117
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0093 0.016
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0048 0.0075
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0019 0.0062 0.0117
Loa Loa (eye worm) hypothetical protein 0.0019 0.0062 0.0117
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0019 0.0062 0.382
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0019 0.0062 0.0117
Loa Loa (eye worm) hypothetical protein 0.0049 0.0232 0.0437
Loa Loa (eye worm) hypothetical protein 0.025 0.1386 0.2612
Trypanosoma brucei short-chain dehydrogenase, putative 0.0019 0.0062 0.0102
Brugia malayi photoreceptor-specific nuclear receptor 0.0039 0.0178 0.0336
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0084 0.0254
Mycobacterium tuberculosis Probable reductase 0.0109 0.0577 0.1228
Onchocerca volvulus 0.023 0.1269 0.8292
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0019 0.0062 0.0117
Onchocerca volvulus 0.004 0.0179 0.1171
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0084 0.0075
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0048 0.0006
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0048 0.0076
Onchocerca volvulus 0.0019 0.0059 0.0386
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0189 0.0436
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0062 0.0117
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0042 0.0196 0.0452
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0062 0.0117
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0156 0.0848 0.1598
Brugia malayi hypothetical protein 0.0019 0.0059 0.0111
Loa Loa (eye worm) dehydrogenase 0.0019 0.0062 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0008 0.0015
Loa Loa (eye worm) hypothetical protein 0.004 0.0179 0.0338
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0015
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0084 0.0144
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0062 0.0117
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0048 0.011
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0084 0.0084
Brugia malayi hypothetical protein 0.0016 0.0043 0.0081
Loa Loa (eye worm) oxidoreductase 0.0019 0.0062 0.0117
Schistosoma mansoni apoferritin-2 0.0008 0 0.0001
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0189 0.0357
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0008 0.0015
Loa Loa (eye worm) hypothetical protein 0.003 0.0122 0.023
Brugia malayi nuclear receptor RXR 0.0019 0.0059 0.0111
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0039 0.0178 0.041
Brugia malayi hypothetical protein 0.0019 0.0062 0.0117
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0043 0.0197 0.029
Giardia lamblia Short-chain dehydrogenase, putative 0.0019 0.0062 0.0165
Echinococcus multilocularis cpg binding protein 0.003 0.0123 0.0123
Brugia malayi MH1 domain containing protein 0.0017 0.0048 0.0091
Loa Loa (eye worm) hypothetical protein 0.0041 0.0187 0.0352
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0084 0.0144
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0064 0.012
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0504 0.095
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.025 0.1386 0.2612
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0227 0.0482
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0162 1
Echinococcus granulosus dna polymerase eta 0.0023 0.0084 0.0194
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0084 0.0084
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0048 0.009
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0512 0.1551
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0059 0.0111
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0062 0.0189
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.0178 0.0178
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0023 0.0043
Schistosoma mansoni serine/threonine protein kinase 0.0585 0.3304 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0062 0.0117
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0048 0.0294
Mycobacterium tuberculosis Conserved protein 0.004 0.0179 0.0381
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0179 0.0381
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.0647 0.1377
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0179 0.0323
Trichomonas vaginalis CMGC family protein kinase 0.0585 0.3304 0.6229
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.0577 0.1228
Schistosoma mansoni synaptic glycoprotein sc2 related 0.025 0.1386 0.4194
Echinococcus multilocularis carbonyl reductase 1 0.0019 0.0062 0.0062
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0059 0.0136
Leishmania major hypothetical protein, conserved 0.0019 0.0062 0.0034
Schistosoma mansoni nuclear hormone receptor 0.0039 0.0178 0.0539
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0084 0.0159
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0062 0.0117
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0019 0.0062 0.0117
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0084 0.0158
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0019 0.0062 0.0132
Schistosoma mansoni retinoic acid receptor RXR 0.0039 0.0178 0.0539
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0048 0.0089
Echinococcus granulosus ferritin 0.0008 0 0.0001
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0585 0.3304 0.6223
Loa Loa (eye worm) DR-78 0.0019 0.0059 0.0111
Loa Loa (eye worm) hypothetical protein 0.0023 0.0084 0.0159
Echinococcus multilocularis carbonyl reductase 1 0.0019 0.0062 0.0062
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0019 0.0062 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0039 0.0178 0.0336
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0062 0.0117
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0062 0.0189
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0062 0.0104
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0044 0.0044
Trypanosoma brucei protein kinase, putative 0.0585 0.3304 0.6223
Echinococcus granulosus cpg binding protein 0.003 0.0123 0.0283
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0504 0.1161
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0019 0.0062 0.0102
Trichomonas vaginalis DNA helicase recq1, putative 0.0019 0.0064 0.012
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0059 0.0136
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0019 0.0062 0.0102
Loa Loa (eye worm) hypothetical protein 0.0051 0.0243 0.0457
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0062 0.0117
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0062 0.0117
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0062 0.0189
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0062 0.0189
Brugia malayi Dehydrogenases, short chain protein 30 0.0019 0.0062 0.0117
Onchocerca volvulus 0.0019 0.0062 0.0407
Loa Loa (eye worm) intermediate filament protein 0.0088 0.0457 0.0861
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0008 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0039 0.0178 0.0336
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0122 0.0369
Leishmania major hypothetical protein, conserved 0.0019 0.0062 0.0034
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0585 0.3304 0.6197
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.0064 0.0405
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0019 0.0062 0.0132
Loa Loa (eye worm) hypothetical protein 0.0021 0.0072 0.0135
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0935 0.5305 1
Echinococcus granulosus hypothetical protein 0.0019 0.0062 0.0144
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0084 0.0144
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.025 0.1386 0.2602
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0019 0.0062 0.0117
Schistosoma mansoni hypothetical protein 0.004 0.0181 0.0547
Echinococcus granulosus hypothetical protein 0.0019 0.0062 0.0144
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0062 0.0117
Onchocerca volvulus 0.0019 0.0062 0.0407
Mycobacterium tuberculosis Probable oxidoreductase 0.0019 0.0062 0.0132
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0064 0.012
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0162 0.0291
Onchocerca volvulus Huntingtin homolog 0.0276 0.1531 1
Schistosoma mansoni steroid dehydrogenase 0.0019 0.0062 0.0189
Onchocerca volvulus Protein ultraspiracle homolog 0.0039 0.0178 0.1163
Leishmania major short chain dehydrogenase-like protein 0.0019 0.0062 0.0034
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0064 0.0107
Treponema pallidum DNA ligase (lig) 0.001 0.0008 0.0472
Echinococcus granulosus steroid dehydrogenase 0.0019 0.0062 0.0144
Brugia malayi hypothetical protein 0.0021 0.0072 0.0135
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0048 0.009
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0019 0.0062 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0039 0.0178 0.0336
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0122 0.0369
Echinococcus granulosus mitogen activated protein kinase 0.0585 0.3304 0.7613
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0019 0.0062 0.0957
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0059 0.0111
Trypanosoma brucei short-chain dehydrogenase, putative 0.0019 0.0062 0.0102
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0019 0.0062 0.0132
Schistosoma mansoni hypothetical protein 0.004 0.0181 0.0547
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.012
Loa Loa (eye worm) steroid hormone receptor 0.0039 0.0178 0.0336
Echinococcus multilocularis geminin 0.0166 0.0901 0.0901
Trichomonas vaginalis CMGC family protein kinase 0.0585 0.3304 0.6229
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0162 0.0468
Loa Loa (eye worm) hypothetical protein 0.0021 0.0072 0.0135
Giardia lamblia Hypothetical protein 0.0019 0.0062 0.0165
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0232 0.0437
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0019 0.0062 0.0117
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0179 0.0338
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.0072 0.0072
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0295 0.0555
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0062 0.0189
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0019 0.0062 0.0117
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0048 0.0075
Giardia lamblia Kinase, CMGC MAPK 0.0585 0.3304 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0064 0.012
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0062 0.0117
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0047 0.0223 0.042
Schistosoma mansoni smad1 5 8 and 0.0017 0.0048 0.0146
Echinococcus multilocularis protein dispatched 1 0.0047 0.0223 0.0223
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0062 0.0104
Loa Loa (eye worm) hypothetical protein 0.004 0.0179 0.0338
Echinococcus granulosus metabotropic glutamate receptor 5 0.005 0.024 0.0553
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0072 0.0135
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0019 0.0062 0.0102
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0253 0.1399 0.2977
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0162 0.0345
Schistosoma mansoni survival motor neuron protein 0.0156 0.0848 0.2566
Echinococcus granulosus expressed protein 0.0008 0 0.0001
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0008 0.0015
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0059 0.0111
Brugia malayi Nuclear hormone receptor-like 1 0.0039 0.0178 0.0336
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0059 0.0136
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0019 0.0062 0.0117
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0019 0.0062 0.0102
Brugia malayi nuclear receptor NHR-88 0.0019 0.0059 0.0111
Onchocerca volvulus 0.004 0.0179 0.1171
Onchocerca volvulus 0.0019 0.0062 0.0407
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.0577 0.1228
Onchocerca volvulus 0.0019 0.0062 0.0407
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0043 0.0067
Brugia malayi Synaptic glycoprotein SC2 0.025 0.1386 0.2612
Trypanosoma brucei short-chain dehydrogenase, putative 0.0019 0.0062 0.0102
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0043 0.0197 0.0371
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0295 0.0892
Brugia malayi Bloom's syndrome protein homolog 0.0019 0.0064 0.012
Echinococcus multilocularis expressed conserved protein 0.009 0.0471 0.0471
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0059 0.0179
Onchocerca volvulus 0.0019 0.0062 0.0407
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0162 0.0224
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0179 0.0381
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0144 0.0271
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.0178 0.041
Schistosoma mansoni hypothetical protein 0.0015 0.0041 0.0125
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0019 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0039 0.0178 0.0336
Entamoeba histolytica short chain dehydrogenase family protein 0.0019 0.0062 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0008 0.0015
Schistosoma mansoni hypothetical protein 0.0166 0.0901 0.2728
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0039 0.0178 0.0539
Echinococcus multilocularis retinol dehydrogenase 13 0.0019 0.0062 0.0062
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.0577 0.1228
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0062 0.0117
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.0647 0.1377
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0048 0.0075
Mycobacterium ulcerans glutaminase 0.0324 0.181 0.3412
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0019 0.0062 0.0117
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0019 0.0062 0.0102
Brugia malayi nuclear receptor NHR-67 0.0019 0.0059 0.0111
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0019 0.0062 0.0117
Entamoeba histolytica hypothetical protein 0.001 0.0008 0.0015
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0295 0.0542
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0064 0.012
Entamoeba histolytica hypothetical protein, conserved 0.0019 0.0062 0.0117
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0059 0.0136
Echinococcus granulosus FTZ F1 alpha 0.0039 0.0178 0.041
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0009 0.002
Loa Loa (eye worm) RecQ helicase 0.0019 0.0064 0.012
Mycobacterium tuberculosis Possible oxidoreductase 0.0019 0.0062 0.0132
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0019 0.0062 0.0144
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0019 0.0062 0.0102
Echinococcus granulosus lamin 0.0088 0.0457 0.1052
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0015
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0023 0.0043
Mycobacterium tuberculosis Probable oxidoreductase 0.0019 0.0062 0.0132
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0059 0.0179
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0039 0.0178 0.0336
Echinococcus multilocularis mitogen activated protein kinase 3 0.0585 0.3304 0.3304
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0062 0.0189
Mycobacterium tuberculosis Probable oxidoreductase 0.0829 0.4696 1
Trypanosoma brucei unspecified product 0.0023 0.0084 0.0144
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0039 0.0178 0.0336
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0197 0.0197
Mycobacterium ulcerans beta-lactamase 0.004 0.0179 0.0337
Loa Loa (eye worm) hypothetical protein 0.0086 0.0447 0.0843
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0179 0.0338
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0585 0.3304 0.6223
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0019 0.0062 0.0132
Loa Loa (eye worm) hypothetical protein 0.0033 0.0144 0.0271
Echinococcus granulosus lamin dm0 0.0088 0.0457 0.1052
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0062 0.0117
Loa Loa (eye worm) hypothetical protein 0.0019 0.0059 0.0111
Loa Loa (eye worm) hypothetical protein 0.0019 0.0062 0.0117
Trypanosoma brucei oxidoreductase-like protein 0.0019 0.0062 0.0102
Onchocerca volvulus 0.0088 0.0457 0.2983
Loa Loa (eye worm) hypothetical protein 0.0039 0.0178 0.0336
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.1048 0.3171
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.0178 0.0178
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0048 0.0048
Schistosoma mansoni short chain dehydrogenase 0.0019 0.0062 0.0189
Schistosoma mansoni ferritin light chain 0.0008 0 0.0001
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0179 0.0338
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0179 0.0381
Schistosoma mansoni blooms syndrome DNA helicase 0.0009 0.0007 0.0022
Toxoplasma gondii ABC1 family protein 0.004 0.0179 0.0324
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0162 0.0306
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0016 0.0036
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0191 0.1048 0.1048
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.001 0.0003
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.025 0.1386 0.2601
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0084 0.0144
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0044 0.0102
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0019 0.0062 0.0117
Schistosoma mansoni metabotropic glutamate receptor 0.002 0.0067 0.0202
Leishmania major quinonoid dihydropteridine reductase 0.0019 0.0062 0.0034
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0019 0.0062 0.0407
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0019 0.0062 0.0144
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0048 0.2925
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0084 0.0144
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0062 0.0117
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0162 0.0291
Schistosoma mansoni hypothetical protein 0.004 0.0181 0.0547
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0039 0.0178 0.041
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0062 0.0399
Mycobacterium ulcerans short chain dehydrogenase 0.0019 0.0062 0.0117
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0059 0.0111
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0034 0.0148 0.0148
Loa Loa (eye worm) dehydrogenase 0.0019 0.0062 0.0117

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 160 uM Tested against Muscarinic acetylcholine receptor M1 expressed in A9 L cell line ChEMBL. 9111297
IC50 (binding) = 22 uM Affinity for muscarinic receptor in rat brian was measured by inhibition of [3H]-(R)-quinuclidinyl benzilate (QNB) binding ChEMBL. 8064804
Smax (functional) = 210 % Maximum stimulation at Muscarinic acetylcholine receptor M1 expressed in A9 L cells ChEMBL. 9111297

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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