Detailed information for compound 1030864

Basic information

Technical information
  • TDR Targets ID: 1030864
  • Name: 4-bromonaphthalen-1-ol
  • MW: 223.066 | Formula: C10H7BrO
  • H donors: 1 H acceptors: 1 LogP: 3.51 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(c2c1cccc2)O
  • InChi: 1S/C10H7BrO/c11-9-5-6-10(12)8-4-2-1-3-7(8)9/h1-6,12H
  • InChiKey: OUNQUWORSXHSJN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-bromo-1-naphthalenol
  • 4-bromo-1-naphthol
  • ALD-N001476
  • ZINC04616836
  • ARONIS000498
  • 1-Bromo-4-hydroxynaphthalene
  • 1-Naphthalenol, 4-bromo-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0588 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0588 0.0411
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.1214 0.1287
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.7437 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.3456 0.4427
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.7437 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.5099 0.6727
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.5099 0.6345
Loa Loa (eye worm) hypothetical protein 0.0074 0.9283 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.5099 0.6727
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0588 1
Schistosoma mansoni ap endonuclease 0.002 0.0588 0.0731
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0294 0.0366
Brugia malayi PHD-finger family protein 0.0026 0.161 0.1086
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0588 0.5
Brugia malayi Bromodomain containing protein 0.004 0.3853 0.3469
Loa Loa (eye worm) hypothetical protein 0.0043 0.4261 0.4413
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.5099 0.6345
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0588 0.5
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0588 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0588 0.5
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.5099 0.4793
Schistosoma mansoni zinc finger protein 0.002 0.0717 0.0891
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0588 0.0411
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.5099 0.6727
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0588 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.5099 0.6727
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0894 0.0667
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0397 0.0114
Schistosoma mansoni ap endonuclease 0.002 0.0588 0.0731
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0294 0.0366
Loa Loa (eye worm) hypothetical protein 0.004 0.3864 0.3972
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0588 0.5
Schistosoma mansoni hypothetical protein 0.0022 0.0894 0.1112
Echinococcus multilocularis zinc finger protein 0.002 0.0717 0.0592
Echinococcus granulosus zinc finger protein 0.002 0.0717 0.0592
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.3456 0.4427
Toxoplasma gondii exonuclease III APE 0.002 0.0588 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.5099 0.5346
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0588 0.0327
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0588 0.5
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0588 0.5
Loa Loa (eye worm) hypothetical protein 0.0045 0.4581 0.4769
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.1214 0.151
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0588 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0294 0.0366
Schistosoma mansoni bromodomain containing protein 0.0066 0.8037 1
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0588 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0294 0.0366
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0588 0.5
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.1214 0.1287
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0588 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.5099 0.6345

Activities

Activity type Activity value Assay description Source Reference
IC90 (functional) < 0.1 ug ml-1 Antituberculosis activity against Mycobacterium tuberculosis H37Rv ChEMBL. 21823589

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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