Detailed information for compound 1031297

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 226.297 | Formula: C13H10N2S
  • H donors: 1 H acceptors: 1 LogP: 3.15 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1ccc2c(n1)ccc(c2)c1cscc1
  • InChi: 1S/C13H10N2S/c14-13-4-2-10-7-9(1-3-12(10)15-13)11-5-6-16-8-11/h1-8H,(H2,14,15)
  • InChiKey: SKHMHSCEONTQTF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0079 0.1357 0.5051
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0123 0.2273 0.3573
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0079 0.1357 0.5051
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.016 0.308 0.484
Trichomonas vaginalis CMGC family protein kinase 0.0315 0.6363 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0112 0.0176
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0079 0.1357 0.5971
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0112 0.0176
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0113 0.2069 0.3251
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0061 0.0095
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0072 0.1189 0.4423
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0142 0.2687 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0529 0.0529
Schistosoma mansoni hypothetical protein 0.0079 0.1357 0.2133
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0112 0.0773
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0112 0.0176
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0315 0.6363 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0113 0.2069 0.3251
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0079 0.1357 0.5971
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0079 0.1357 0.5051
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.016 0.308 0.484
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0061 0.0095
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0112 0.0176
Toxoplasma gondii cytochrome p450 superfamily protein 0.0079 0.1357 0.2133
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0112 0.0112
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0061 0.0294
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0061 0.0095
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0079 0.1357 0.5051
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0079 0.1357 0.5051
Leishmania major cytochrome p450-like protein 0.0079 0.1357 0.2133
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0113 0.2069 0.3251
Brugia malayi Cytochrome P450 family protein 0.0142 0.2687 0.2687
Echinococcus multilocularis mitogen activated protein kinase 3 0.016 0.308 0.484
Trypanosoma brucei cytochrome P450, putative 0.0142 0.2687 0.4223
Brugia malayi Cytochrome P450 family protein 0.0176 0.3418 0.3418
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0079 0.1357 0.5971
Brugia malayi cytochrome P450 0.0079 0.1357 0.1357
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0079 0.1357 0.5051
Loa Loa (eye worm) hypothetical protein 0.0084 0.1453 0.1453
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0112 0.0112
Brugia malayi steroid hormone receptor 0.0021 0.0112 0.0112
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0041 0.0529 0.0832
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0112 0.0176
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0072 0.1189 0.1868
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.016 0.308 0.484
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0112 0.0112
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0112 0.0112
Echinococcus granulosus lamin 0.0084 0.1453 0.2283
Loa Loa (eye worm) cytochrome P450 family protein 0.0142 0.2687 0.2687
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0079 0.1357 0.5051
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.016 0.308 0.308
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0079 0.1357 0.2133
Loa Loa (eye worm) hypothetical protein 0.0113 0.2069 0.2069
Loa Loa (eye worm) hypothetical protein 0.0063 0.0998 0.0998
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.016 0.308 0.484
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0112 0.0112
Echinococcus granulosus mitogen activated protein kinase 0.016 0.308 0.484
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0112 0.0176
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0079 0.1357 0.5971
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0113 0.2069 0.3251
Loa Loa (eye worm) hypothetical protein 0.0082 0.142 0.142
Schistosoma mansoni serine/threonine protein kinase 0.0315 0.6363 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0079 0.1357 0.2133
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0072 0.1189 0.1868
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0112 0.0112
Mycobacterium leprae putative cytochrome p450 0.0079 0.1357 1
Schistosoma mansoni coup transcription factor 0.0021 0.0112 0.0176
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0112 0.0176
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0079 0.1357 0.2133
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0079 0.1357 0.5971
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0079 0.1357 0.5051
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0112 0.0112
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0113 0.2069 0.3251
Brugia malayi nuclear receptor NHR-88 0.0021 0.0112 0.0112
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0315 0.6363 1
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0315 0.6363 1
Brugia malayi ecdysteroid receptor 0.0021 0.0112 0.0112
Onchocerca volvulus 0.0021 0.0112 0.0773
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0112 0.0112
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0112 0.0112
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.2273 0.8459
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0072 0.1189 0.1189
Schistosoma mansoni cytochrome P450 0.0079 0.1357 0.2133
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0079 0.1357 0.5971
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0079 0.1357 0.5051
Loa Loa (eye worm) hypothetical protein 0.0021 0.0112 0.0112
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0079 0.1357 0.5051
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0045 0.0624 0.0624
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0061 0.0095
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0112 0.0176
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0112 0.0176
Trichomonas vaginalis CMGC family protein kinase 0.016 0.308 0.484
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0079 0.1357 0.5971
Loa Loa (eye worm) intermediate filament protein 0.0084 0.1453 0.1453
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0079 0.1357 0.5051
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.0885 0.0885
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0112 0.0176
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0315 0.6363 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0885 0.1391
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.016 0.308 0.484
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0061 0.0095
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0112 0.0176
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0113 0.2069 0.3251
Loa Loa (eye worm) hypothetical protein 0.0021 0.0112 0.0112
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0123 0.2273 0.3573
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0079 0.1357 0.5051
Echinococcus multilocularis dual specificity protein kinase clk2 0.0315 0.6363 1
Leishmania major protein kinase, putative 0.0315 0.6363 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0061 0.0061
Echinococcus granulosus lamin dm0 0.0084 0.1453 0.2283
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0079 0.1357 0.5051
Schistosoma mansoni aldehyde dehydrogenase 0.0123 0.2273 0.3573
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0885 0.1391
Onchocerca volvulus 0.0084 0.1453 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0112 0.0112
Schistosoma mansoni lamin 0.0084 0.1453 0.2283
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0079 0.1357 0.2133
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0315 0.6363 1
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0079 0.1357 0.5971
Loa Loa (eye worm) hypothetical protein 0.0311 0.6282 0.6282
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0061 0.0095
Echinococcus granulosus lysine specific demethylase 5A 0.0057 0.0885 0.1391
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0315 0.6363 0.6363
Echinococcus multilocularis lamin 0.0084 0.1453 0.2283
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0079 0.1357 0.5051
Brugia malayi intermediate filament protein 0.0084 0.1453 0.1453
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0112 0.0112
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0112 0.0773
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0079 0.1357 0.5971
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0112 0.0112
Echinococcus multilocularis 0.0079 0.1357 0.2133
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0112 0.0176
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0112 0.0112
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0112 0.0176
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0079 0.1357 0.5971
Loa Loa (eye worm) cytochrome P450 family protein 0.0176 0.3418 0.3418
Plasmodium falciparum protein serine/threonine kinase-1 0.0315 0.6363 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0112 0.0176
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0112 0.0176
Schistosoma mansoni aldehyde dehydrogenase 0.0123 0.2273 0.3573
Brugia malayi Intermediate filament tail domain containing protein 0.0084 0.1453 0.1453
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0072 0.1189 0.5229
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0061 0.0095
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.016 0.308 0.484
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0112 0.0112
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0112 0.0176
Giardia lamblia Kinase, CMGC CLK 0.0315 0.6363 1
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0079 0.1357 0.5051
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0113 0.2069 0.3251
Echinococcus multilocularis ubiquitin specific protease 41 0.0113 0.2069 0.3251
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0885 0.1391
Trichomonas vaginalis CMGC family protein kinase 0.016 0.308 0.484
Echinococcus multilocularis 0.0311 0.6282 0.9872
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0113 0.2069 0.3251
Loa Loa (eye worm) hypothetical protein 0.0039 0.0497 0.0497
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0061 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0112 0.0176
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0079 0.1357 0.5971
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0061 0.0061
Loa Loa (eye worm) CYP4Cod1 0.0142 0.2687 0.2687
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0079 0.1357 0.5051
Echinococcus granulosus dual specificity protein kinase clk2 0.0315 0.6363 1
Schistosoma mansoni intermediate filament proteins 0.0084 0.1453 0.2283
Trichomonas vaginalis CMGC family protein kinase 0.016 0.308 0.484
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0123 0.2273 1
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0079 0.1357 0.5051
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0113 0.2069 0.3251
Toxoplasma gondii exonuclease III APE 0.0018 0.0061 0.0095
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0112 0.0176
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0079 0.1357 0.5971
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0885 0.1391
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0084 0.1453 0.1453
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.2273 0.8459
Onchocerca volvulus 0.0084 0.1453 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0061 0.0095
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0041 0.0529 0.0832
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0061 0.0095
Schistosoma mansoni lamin 0.0084 0.1453 0.2283
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0079 0.1357 0.5971
Echinococcus multilocularis mitogen activated protein kinase 0.016 0.308 0.484
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0112 0.0176
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0079 0.1357 0.2133
Trichomonas vaginalis CMGC family protein kinase 0.016 0.308 0.484
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0112 0.0176
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0079 0.1357 0.5971
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0112 0.0112
Schistosoma mansoni ap endonuclease 0.0018 0.0061 0.0095
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0315 0.6363 1
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0079 0.1357 0.5971
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0112 0.0112
Schistosoma mansoni ap endonuclease 0.0018 0.0061 0.0095
Loa Loa (eye worm) hypothetical protein 0.0021 0.0112 0.0112
Echinococcus multilocularis musashi 0.0084 0.1453 0.2283
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0315 0.6363 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0112 0.0112
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.016 0.308 0.484
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0112 0.0112
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.2273 0.8459
Brugia malayi Cytochrome P450 family protein 0.0079 0.1357 0.1357
Brugia malayi jmjC domain containing protein 0.0057 0.0885 0.0885
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0113 0.2069 0.3251
Leishmania major cytochrome p450-like protein 0.0142 0.2687 0.4223
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0061 0.0267
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0885 0.1391
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0112 0.0176
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0112 0.0112
Brugia malayi Protein kinase domain containing protein 0.0315 0.6363 0.6363
Giardia lamblia Kinase, CMGC MAPK 0.016 0.308 0.484
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0113 0.2069 1
Brugia malayi Cytochrome P450 family protein 0.0142 0.2687 0.2687
Echinococcus granulosus mitogen activated protein kinase 3 0.016 0.308 0.484
Echinococcus granulosus intermediate filament protein 0.0084 0.1453 0.2283
Trichomonas vaginalis conserved hypothetical protein 0.0113 0.2069 0.3251
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0112 0.0176
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0061 0.5
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0112 0.0176
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0113 0.2069 0.3251
Schistosoma mansoni serine/threonine protein kinase 0.0315 0.6363 1
Brugia malayi cytoplasmic intermediate filament protein 0.0045 0.0624 0.0624
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0079 0.1357 0.5971
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0113 0.2069 0.3251
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0061 0.0226
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0113 0.2069 0.3251
Brugia malayi MAP kinase sur-1 0.016 0.308 0.308
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0123 0.2273 0.3573
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0079 0.1357 0.5971
Echinococcus granulosus ubiquitin specific protease 41 0.0113 0.2069 0.3251
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0072 0.1189 0.1868
Loa Loa (eye worm) hypothetical protein 0.0021 0.0112 0.0112
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0856 0.0856
Loa Loa (eye worm) hypothetical protein 0.0021 0.0112 0.0112
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0112 0.0176
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0112 0.0112
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0112 0.0176
Leishmania major cytochrome p450-like protein 0.0079 0.1357 0.2133
Loa Loa (eye worm) cytochrome P450 0.0079 0.1357 0.1357
Leishmania major protein kinase, putative 0.0315 0.6363 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0142 0.2687 0.2687
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0072 0.1189 0.1868
Echinococcus multilocularis lamin dm0 0.0084 0.1453 0.2283
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0112 0.0112
Brugia malayi nuclear hormone receptor 0.0021 0.0112 0.0112
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.016 0.308 0.484
Plasmodium vivax serine/threonine kinase-1, putative 0.0315 0.6363 1
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0079 0.1357 0.5971
Loa Loa (eye worm) hypothetical protein 0.0021 0.0112 0.0112
Echinococcus granulosus cytochrome P450 2K1 0.0079 0.1357 0.2133
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0112 0.0112
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0112 0.0112
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0061 0.0095
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0486 1 1
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0079 0.1357 0.5971
Loa Loa (eye worm) hypothetical protein 0.0021 0.0112 0.0112
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0112 0.0112
Trypanosoma cruzi cytochrome P450, putative 0.0142 0.2687 0.4223
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0079 0.1357 0.5971
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0112 0.0176
Mycobacterium leprae Conserved hypothetical protein 0.0079 0.1357 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0113 0.2069 0.2069
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0061 0.0095
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0112 0.0176
Toxoplasma gondii aldehyde dehydrogenase 0.0123 0.2273 0.3573
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0112 0.0176
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0072 0.1189 0.4423
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0112 0.0112
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0885 0.1391
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0079 0.1357 0.5051
Echinococcus granulosus hypothetical protein 0.0311 0.6282 0.9872
Trypanosoma cruzi cytochrome P450, putative 0.0142 0.2687 0.4223
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0112 0.0773
Brugia malayi jmjC domain containing protein 0.0057 0.0885 0.0885
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0112 0.0176
Schistosoma mansoni serine/threonine protein kinase 0.016 0.308 0.484
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0112 0.0176
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0079 0.1357 0.5051
Trypanosoma brucei protein kinase, putative 0.016 0.308 0.484
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0079 0.1357 0.5051
Loa Loa (eye worm) hypothetical protein 0.0039 0.0497 0.0497

Activities

Activity type Activity value Assay description Source Reference
Kd (binding) = 38.8 uM Binding affinity to BACE1 after 90 seconds by surface plasmon resonance assay ChEMBL. 21707077

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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