Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | bromodomain containing protein | 0.0062 | 0.1001 | 0.1339 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0137 | 0.2661 | 0.4933 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.1254 | 0.1952 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0058 | 0.0924 | 0.1236 |
Loa Loa (eye worm) | TAR-binding protein | 0.0257 | 0.5316 | 0.8278 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0307 | 0.6421 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0063 | 0.1033 | 0.1825 |
Echinococcus multilocularis | zinc finger protein | 0.0019 | 0.0055 | 0.0073 |
Schistosoma mansoni | tar DNA-binding protein | 0.0257 | 0.5316 | 0.7108 |
Schistosoma mansoni | hypothetical protein | 0.0355 | 0.7478 | 1 |
Leishmania major | importin beta-1 subunit, putative | 0.0023 | 0.0146 | 0.0105 |
Schistosoma mansoni | tar DNA-binding protein | 0.0257 | 0.5316 | 0.7108 |
Schistosoma mansoni | hypothetical protein | 0.0063 | 0.1033 | 0.1382 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0119 | 0.0159 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.1033 | 0.1609 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0069 | 0.1151 | 0.1793 |
Brugia malayi | RNA, U transporter 1 | 0.0082 | 0.1439 | 0.26 |
Mycobacterium ulcerans | hypothetical protein | 0.0073 | 0.1254 | 0.3632 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0142 | 0.2774 | 0.371 |
Schistosoma mansoni | hypothetical protein | 0.0137 | 0.2661 | 0.3559 |
Echinococcus granulosus | tar DNA binding protein | 0.0257 | 0.5316 | 0.7108 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0073 | 0.1254 | 0.1676 |
Echinococcus granulosus | dna polymerase kappa | 0.002 | 0.0078 | 0.0104 |
Leishmania major | hypothetical protein, conserved | 0.0073 | 0.1254 | 0.1796 |
Echinococcus multilocularis | chromobox protein 1 | 0.0069 | 0.1151 | 0.154 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0554 | 0.0864 |
Brugia malayi | TAR-binding protein | 0.0257 | 0.5316 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0073 | 0.1254 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0257 | 0.5316 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0073 | 0.1254 | 1 |
Brugia malayi | chromobox protein homolog 3 | 0.0039 | 0.0483 | 0.0774 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0027 | 0.0234 | 0.1332 |
Brugia malayi | PHD-finger family protein | 0.0024 | 0.017 | 0.0177 |
Loa Loa (eye worm) | RNA binding protein | 0.0257 | 0.5316 | 0.8278 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0073 | 0.1254 | 0.1676 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0029 | 0.0267 | 0.0357 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0316 | 0.6626 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0073 | 0.1254 | 0.2245 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0483 | 0.0752 |
Echinococcus multilocularis | tar DNA binding protein | 0.0257 | 0.5316 | 0.7108 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0267 | 0.0415 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0142 | 0.2774 | 0.371 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0073 | 0.1254 | 0.1185 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0316 | 0.6626 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0073 | 0.1254 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0037 | 0.046 | 0.0731 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0063 | 0.1033 | 0.1382 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.002 | 0.0078 | 0.0104 |
Schistosoma mansoni | ran | 0.0021 | 0.0099 | 0.0132 |
Echinococcus multilocularis | geminin | 0.0355 | 0.7478 | 1 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0146 | 0.0585 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0073 | 0.1254 | 0.3632 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0073 | 0.1254 | 0.1796 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0409 | 0.0547 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.1254 | 0.1952 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0044 | 0.0614 | 0.0819 |
Leishmania major | GTP-binding protein, putative | 0.0021 | 0.0099 | 0.0032 |
Echinococcus granulosus | dna polymerase eta | 0.002 | 0.0078 | 0.0104 |
Echinococcus granulosus | GPCR family 2 | 0.0063 | 0.1033 | 0.1382 |
Echinococcus multilocularis | dna polymerase eta | 0.002 | 0.0078 | 0.0104 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0257 | 0.5316 | 0.8278 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0099 | 0.0032 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0146 | 0.0585 |
Mycobacterium ulcerans | hypothetical protein | 0.0166 | 0.3315 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.1254 | 0.1952 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.0548 | 0.3999 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.1254 | 0.1952 |
Mycobacterium tuberculosis | Conserved protein | 0.0073 | 0.1254 | 0.1185 |
Brugia malayi | N-terminal motif family protein | 0.0177 | 0.3542 | 0.6613 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0316 | 0.6626 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0073 | 0.1254 | 1 |
Plasmodium vivax | importin-beta 2, putative | 0.0029 | 0.0267 | 0.1454 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0299 | 0.0466 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0142 | 0.2774 | 0.371 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0044 | 0.0614 | 0.0819 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0023 | 0.0146 | 0.0105 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0063 | 0.1033 | 0.1382 |
Echinococcus granulosus | zinc finger protein | 0.0019 | 0.0055 | 0.0073 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0073 | 0.1254 | 0.1185 |
Schistosoma mansoni | ran | 0.0021 | 0.0099 | 0.0132 |
Trichomonas vaginalis | chromobox protein, putative | 0.0069 | 0.1151 | 0.9131 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0119 | 0.0159 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0073 | 0.1254 | 0.1676 |
Schistosoma mansoni | tar DNA-binding protein | 0.0257 | 0.5316 | 0.7108 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0142 | 0.2774 | 0.371 |
Schistosoma mansoni | hypothetical protein | 0.0355 | 0.7478 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.015 | 0.2941 | 0.4373 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0099 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0073 | 0.1254 | 0.1676 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.02 | 0.4064 | 0.7611 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0063 | 0.1033 | 0.1609 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0021 | 0.0099 | 0.0132 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3542 | 0.5516 |
Echinococcus granulosus | importin subunit beta 1 | 0.0029 | 0.0267 | 0.0357 |
Schistosoma mansoni | chromobox protein | 0.0069 | 0.1151 | 0.154 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0073 | 0.1254 | 0.1185 |
Echinococcus multilocularis | snurportin 1 | 0.0307 | 0.6421 | 0.8586 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0.0146 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0073 | 0.1254 | 1 |
Schistosoma mansoni | chromobox protein | 0.0069 | 0.1151 | 0.154 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0078 | 0.0104 |
Brugia malayi | RNA binding protein | 0.0257 | 0.5316 | 1 |
Trichomonas vaginalis | ran, putative | 0.0021 | 0.0099 | 0.018 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0099 | 0.0154 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0078 | 0.0121 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0142 | 0.2774 | 0.371 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0073 | 0.1254 | 0.1952 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0017 | 0.0013 | 0.0021 |
Trichomonas vaginalis | esterase, putative | 0.0073 | 0.1254 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.1254 | 0.1952 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0073 | 0.1254 | 0.1796 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.0548 | 0.3999 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0027 | 0.0234 | 0.1332 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0409 | 0.0547 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0054 | 0.0829 | 0.1148 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.002 | 0.0078 | 0.0104 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0142 | 0.2774 | 0.432 |
Plasmodium falciparum | importin beta, putative | 0.0029 | 0.0267 | 1 |
Onchocerca volvulus | 0.0073 | 0.1254 | 0.2944 | |
Schistosoma mansoni | DNA polymerase eta | 0.002 | 0.0078 | 0.0104 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0267 | 0.0289 |
Schistosoma mansoni | hypothetical protein | 0.0307 | 0.6421 | 0.8586 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0483 | 0.3448 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0166 | 0.3315 | 0.3263 |
Echinococcus multilocularis | chromobox protein 1 | 0.0069 | 0.1151 | 0.154 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0513 | 0.0799 |
Trichomonas vaginalis | chromobox protein, putative | 0.0069 | 0.1151 | 0.9131 |
Schistosoma mansoni | tar DNA-binding protein | 0.0257 | 0.5316 | 0.7108 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0099 | 0.004 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0039 | 0.0483 | 0.0568 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0073 | 0.1254 | 0.3632 |
Echinococcus multilocularis | GPCR, family 2 | 0.0063 | 0.1033 | 0.1382 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0073 | 0.1254 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0073 | 0.1254 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0073 | 0.1254 | 0.1185 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0142 | 0.2774 | 0.371 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0073 | 0.1254 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0073 | 0.1254 | 0.2245 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0073 | 0.1254 | 0.1185 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0073 | 0.1254 | 0.1185 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.1254 | 0.1952 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0063 | 0.1033 | 0.1825 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0044 | 0.0614 | 0.0819 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1163 | 0.1811 |
Loa Loa (eye worm) | beta-lactamase | 0.0073 | 0.1254 | 0.1952 |
Schistosoma mansoni | hypothetical protein | 0.0063 | 0.1033 | 0.1382 |
Brugia malayi | beta-lactamase family protein | 0.0073 | 0.1254 | 0.2245 |
Mycobacterium ulcerans | beta-lactamase | 0.0073 | 0.1254 | 0.3632 |
Schistosoma mansoni | tar DNA-binding protein | 0.0257 | 0.5316 | 0.7108 |
Brugia malayi | beta-lactamase | 0.0073 | 0.1254 | 0.2245 |
Schistosoma mansoni | zinc finger protein | 0.0019 | 0.0055 | 0.0073 |
Trichomonas vaginalis | importin beta-1, putative | 0.0023 | 0.0146 | 0.0585 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0044 | 0.0614 | 0.0819 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0142 | 0.2774 | 0.371 |
Onchocerca volvulus | 0.0073 | 0.1254 | 0.2944 | |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.02 | 0.4064 | 0.633 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0021 | 0.0099 | 0.0132 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0063 | 0.1033 | 0.1382 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.015 | 0.2941 | 0.4373 |
Loa Loa (eye worm) | PHD-finger family protein | 0.002 | 0.0078 | 0.0121 |
Brugia malayi | Importin beta-1 subunit | 0.0029 | 0.0267 | 0.0361 |
Toxoplasma gondii | hypothetical protein | 0.0051 | 0.0759 | 0.5716 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0142 | 0.2774 | 0.5148 |
Echinococcus granulosus | geminin | 0.0355 | 0.7478 | 1 |
Echinococcus granulosus | snurportin 1 | 0.0307 | 0.6421 | 0.8586 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0073 | 0.1254 | 0.1185 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.02 | 0.4064 | 0.7611 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0041 | 0.0548 | 0.0768 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.015 | 0.2941 | 0.4373 |
Echinococcus granulosus | chromobox protein 1 | 0.0069 | 0.1151 | 0.154 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0073 | 0.1254 | 0.1796 |
Schistosoma mansoni | importin beta-1 | 0.0029 | 0.0267 | 0.0357 |
Schistosoma mansoni | hypothetical protein | 0.0063 | 0.1033 | 0.1382 |
Mycobacterium ulcerans | lipase LipD | 0.0073 | 0.1254 | 0.3632 |
Echinococcus granulosus | chromobox protein 1 | 0.0069 | 0.1151 | 0.154 |
Onchocerca volvulus | 0.0073 | 0.1254 | 0.2944 | |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.002 | 0.0078 | 0.0104 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.2661 | 0.4145 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0058 | 0.0924 | 0.1236 |
Brugia malayi | Heterochromatin protein 1 | 0.0069 | 0.1151 | 0.205 |
Schistosoma mansoni | hypothetical protein | 0.0063 | 0.1033 | 0.1382 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0267 | 0.0289 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0119 | 0.0159 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0029 | 0.0267 | 0.1454 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.002 | 0.0078 | 0.0121 |
Entamoeba histolytica | Ran family GTPase | 0.0021 | 0.0099 | 0.3073 |
Trypanosoma brucei | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0099 | 0.0032 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.002 | 0.0078 | 0.0104 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0462 | 0.0719 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0063 | 0.1033 | 0.1382 |
Mycobacterium leprae | Probable lipase LipE | 0.0073 | 0.1254 | 0.5 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0177 | 0.3542 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0483 | 0.3448 |
Mycobacterium tuberculosis | Conserved protein | 0.0073 | 0.1254 | 0.1185 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0316 | 0.6626 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.4064 | 0.633 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0073 | 0.1254 | 0.1185 |
Echinococcus multilocularis | dna polymerase kappa | 0.002 | 0.0078 | 0.0104 |
Brugia malayi | Bromodomain containing protein | 0.0073 | 0.1255 | 0.2249 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0099 | 0.0032 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.