Detailed information for compound 1031467

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 470.568 | Formula: C30H26N6
  • H donors: 1 H acceptors: 3 LogP: 5.19 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccc(nc1)N1CCN(CC1)Cc1ccc(cc1)c1cccc(c1)c1nc2c([nH]1)cccc2
  • InChi: 1S/C30H26N6/c31-19-23-10-13-29(32-20-23)36-16-14-35(15-17-36)21-22-8-11-24(12-9-22)25-4-3-5-26(18-25)30-33-27-6-1-2-7-28(27)34-30/h1-13,18,20H,14-17,21H2,(H,33,34)
  • InChiKey: PIPONYAOPSGBQJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0195 0.2083 0.5762
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0555 0.0314
Echinococcus granulosus mitogen activated protein kinase 0.0162 0.1686 0.3867
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0515 0.1202
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0195 0.2083 1
Mycobacterium ulcerans putative regulatory protein 0.0187 0.199 0.5434
Brugia malayi hypoxia-induced factor 1 0.0781 0.9204 0.9197
Loa Loa (eye worm) hypothetical protein 0.0039 0.0199 0.0165
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0376 0.4284 1
Leishmania major protein kinase, putative 0.0376 0.4284 1
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0195 0.2083 1
Toxoplasma gondii cytochrome p450 superfamily protein 0.0195 0.2083 0.4284
Echinococcus granulosus mitogen activated protein kinase 3 0.0162 0.1686 0.3867
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.023 0.2517 0.5411
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0195 0.2083 0.5762
Schistosoma mansoni lipoxygenase 0.0103 0.0974 0.2273
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0453 0.0373
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0515 0.0282
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0453 0.0957
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0515 0.021
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0376 0.4284 1
Leishmania major protein kinase, putative 0.0376 0.4284 1
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0195 0.2083 1
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0195 0.2083 0.5762
Loa Loa (eye worm) hypoxia-induced factor 1 0.0781 0.9204 0.9201
Echinococcus multilocularis aryl hydrocarbon receptor 0.0066 0.0518 0.1112
Loa Loa (eye worm) doublecortin family protein 0.0039 0.0199 0.0165
Plasmodium falciparum protein serine/threonine kinase-1 0.0376 0.4284 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0453 0.0065
Schistosoma mansoni ap endonuclease 0.0059 0.0434 0.1013
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0162 0.1686 0.3251
Echinococcus multilocularis mitogen activated protein kinase 3 0.0162 0.1686 0.3867
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.006 0.0453 0.1057
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0195 0.2083 0.5762
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0555 0.0456
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.023 0.2517 0.5411
Leishmania major protein kinase, putative 0.007 0.057 0.0354
Echinococcus multilocularis lamin dm0 0.0055 0.0396 0.0823
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0195 0.2083 0.5762
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0195 0.2083 0.5762
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0195 0.2083 0.5762
Leishmania major cathepsin L-like protease 0.0069 0.0555 0.0314
Trichomonas vaginalis guanylate cyclase, putative 0.0066 0.0518 0.0219
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0174 0.1833 0.4214
Echinococcus multilocularis dual specificity protein kinase clk2 0.0376 0.4284 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0059 0.0434 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0453 0.0065
Schistosoma mansoni hypothetical protein 0.004 0.0213 0.0498
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0518 0.0219
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0195 0.2083 0.5762
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.006 0.0453 0.0049
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0376 0.4284 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0518 0.0485
Loa Loa (eye worm) cytochrome P450 family protein 0.059 0.6888 0.6878
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0555 0.0314
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0195 0.2083 0.5762
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0515 0.049
Echinococcus multilocularis caspase 2 0.0058 0.0424 0.089
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0195 0.2083 0.5762
Loa Loa (eye worm) hypothetical protein 0.0058 0.0424 0.0391
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.023 0.2517 0.2454
Schistosoma mansoni rab6-interacting 0.0039 0.0199 0.0465
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.007 0.057 0.0496
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0066 0.0518 0.0362
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0199 0.0359
Schistosoma mansoni lamin 0.0055 0.0396 0.0924
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0195 0.2083 1
Leishmania major cytochrome p450-like protein 0.0294 0.3297 0.7435
Leishmania major cathepsin L-like protease 0.0069 0.0555 0.0314
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0515 0.1202
Brugia malayi intermediate filament protein 0.0055 0.0396 0.0315
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0059 0.0434 0.0401
Brugia malayi exodeoxyribonuclease III family protein 0.0059 0.0434 0.0354
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0195 0.2083 1
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0195 0.2083 0.4284
Trichomonas vaginalis CMGC family protein kinase 0.0162 0.1686 0.3251
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0195 0.2083 0.5762
Echinococcus granulosus aryl hydrocarbon receptor 0.0066 0.0518 0.1112
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.023 0.2517 0.583
Echinococcus multilocularis lamin 0.0055 0.0396 0.0823
Trypanosoma cruzi cruzipain precursor, putative 0.0069 0.0555 0.0456
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0195 0.2083 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0059 0.0434 0.0913
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0059 0.0434 0.0147
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0195 0.2083 0.4368
Plasmodium vivax serine/threonine kinase-1, putative 0.0376 0.4284 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0162 0.1686 0.335
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0195 0.2083 1
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0066 0.0518 0.0219
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0195 0.2083 0.5762
Echinococcus multilocularis RUN 0.0039 0.0199 0.0359
Brugia malayi MAP kinase sur-1 0.0162 0.1686 0.1616
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0555 0.0314
Echinococcus multilocularis 0.0371 0.4232 0.9877
Loa Loa (eye worm) cytochrome P450 0.0195 0.2083 0.2056
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0555 0.0314
Brugia malayi bHLH-PAS transcription factor 0.0187 0.199 0.1922
Schistosoma mansoni aryl hydrocarbon receptor 0.0252 0.2786 0.6503
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0162 0.1686 0.1657
Trichomonas vaginalis conserved hypothetical protein 0.023 0.2517 0.5411
Schistosoma mansoni serine/threonine protein kinase 0.0376 0.4284 1
Echinococcus granulosus apoptotic protease activating factor 1 0.004 0.0213 0.0392
Echinococcus multilocularis apoptotic protease activating factor 1 0.004 0.0213 0.0392
Brugia malayi Cytochrome P450 family protein 0.059 0.6888 0.6862
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0555 0.0314
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0195 0.2083 1
Onchocerca volvulus 0.0066 0.0518 0.1783
Trichomonas vaginalis adenylate cyclase, putative 0.0066 0.0518 0.0219
Brugia malayi Cell death protein 3 precursor 0.0058 0.0424 0.0344
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.007 0.057 0.0496
Brugia malayi Cytochrome P450 family protein 0.0294 0.3297 0.3241
Schistosoma mansoni lipoxygenase 0.0174 0.1833 0.4278
Giardia lamblia Kinase, CMGC MAPK 0.0162 0.1686 0.3251
Loa Loa (eye worm) hypothetical protein 0.01 0.0935 0.0904
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0518 0.0219
Trichomonas vaginalis CMGC family protein kinase 0.0376 0.4284 1
Trypanosoma cruzi cytochrome P450, putative 0.0294 0.3297 0.7473
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0162 0.1686 0.3251
Schistosoma mansoni hypothetical protein 0.0195 0.2083 0.4863
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.023 0.2517 0.5478
Echinococcus granulosus RUN 0.0039 0.0199 0.0359
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0555 0.0314
Mycobacterium leprae putative cytochrome p450 0.0195 0.2083 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0515 0.0282
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.023 0.2517 1
Echinococcus multilocularis transfer RNA-Lys 0.0187 0.199 0.4584
Schistosoma mansoni single-minded 0.0252 0.2786 0.6503
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0195 0.2083 0.5762
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0174 0.1833 0.4214
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0195 0.2083 0.4368
Echinococcus granulosus dual specificity protein kinase clk2 0.0376 0.4284 1
Echinococcus multilocularis ubiquitin specific protease 41 0.023 0.2517 0.583
Loa Loa (eye worm) hypothetical protein 0.0027 0.0047 0.0012
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0515 0.1104
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0162 0.1686 0.335
Loa Loa (eye worm) hypothetical protein 0.0039 0.0199 0.0165
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0199 0.0359
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0396 0.0362
Schistosoma mansoni intermediate filament proteins 0.0055 0.0396 0.0924
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0195 0.2083 0.5762
Onchocerca volvulus 0.004 0.0213 0.0079
Loa Loa (eye worm) hypothetical protein 0.0847 1 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0199 0.0359
Trichomonas vaginalis CMGC family protein kinase 0.0162 0.1686 0.3251
Echinococcus granulosus caspase 2 0.0058 0.0424 0.089
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.023 0.2517 0.5411
Loa Loa (eye worm) CYP4Cod1 0.0294 0.3297 0.3273
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0195 0.2083 1
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0555 0.0456
Schistosoma mansoni ap endonuclease 0.0059 0.0434 0.1013
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0066 0.0518 0.1112
Echinococcus granulosus intermediate filament protein 0.0055 0.0396 0.0823
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0162 0.1686 0.335
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0515 0.021
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0515 0.0282
Echinococcus multilocularis mitogen activated protein kinase 0.0162 0.1686 0.3867
Giardia lamblia Kinase, CMGC CLK 0.0376 0.4284 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.023 0.2517 0.583
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0555 0.0314
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0434 0.0575
Schistosoma mansoni caspase-7 (C14 family) 0.0058 0.0424 0.0991
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0195 0.2083 0.5762
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0515 0.1104
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0066 0.0518 0.0219
Leishmania major protein kinase, putative 0.007 0.057 0.0354
Brugia malayi PAS domain containing protein 0.0252 0.2786 0.2725
Echinococcus granulosus hypothetical protein 0.0371 0.4232 0.9877
Loa Loa (eye worm) hypothetical protein 0.0055 0.0396 0.0362
Trichomonas vaginalis guanylate cyclase, putative 0.0066 0.0518 0.0219
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.023 0.2517 0.5876
Echinococcus granulosus Polycystic kidney disease protein 0.0039 0.0199 0.0359
Schistosoma mansoni serine/threonine protein kinase 0.0162 0.1686 0.3935
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0195 0.2083 1
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0195 0.2083 0.5762
Schistosoma mansoni serine/threonine protein kinase 0.0376 0.4284 1
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0555 0.0456
Onchocerca volvulus 0.0055 0.0396 0.1098
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0066 0.0518 0.0362
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0376 0.4284 1
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0066 0.0518 0.0219
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0195 0.2083 1
Trichomonas vaginalis CMGC family protein kinase 0.0162 0.1686 0.3251
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0066 0.0518 0.0219
Brugia malayi hypothetical protein 0.0039 0.0199 0.0117
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0195 0.2083 1
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0195 0.2083 1
Trypanosoma cruzi cytochrome P450, putative 0.0294 0.3297 0.7473
Brugia malayi Cytochrome P450 family protein 0.0195 0.2083 0.2017
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0195 0.2083 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.023 0.2517 0.5411
Echinococcus granulosus cytochrome P450 2K1 0.0195 0.2083 0.4806
Brugia malayi hypothetical protein 0.0039 0.0199 0.0117
Loa Loa (eye worm) hypothetical protein 0.0054 0.0383 0.035
Echinococcus granulosus lamin 0.0055 0.0396 0.0823
Echinococcus granulosus lamin dm0 0.0055 0.0396 0.0823
Loa Loa (eye worm) hypothetical protein 0.004 0.0213 0.0179
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.023 0.2517 0.583
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0376 0.4284 0.4264
Leishmania major cytochrome p450-like protein 0.0195 0.2083 0.4284
Echinococcus granulosus single minded 2 0.0187 0.199 0.4584
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0059 0.0434 0.0147
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.023 0.2517 0.5876
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0294 0.3297 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0555 0.0314
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0195 0.2083 1
Trypanosoma brucei protein kinase, putative 0.0162 0.1686 0.3251
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0066 0.0518 0.0485
Onchocerca volvulus Cell death protein 3 homolog 0.0058 0.0424 0.1258
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0477 0.5507 0.5491
Schistosoma mansoni polycystin 1-related 0.0039 0.0199 0.0465
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0162 0.1686 0.3251
Brugia malayi hypothetical protein 0.004 0.0213 0.0131
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.006 0.0453 0.0114
Brugia malayi Doublecortin family protein 0.0039 0.0199 0.0117
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0356 0.0322
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0396 0.0315
Leishmania major cathepsin L-like protease 0.0069 0.0555 0.0314
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0195 0.2083 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0162 0.1686 0.3251
Echinococcus granulosus ubiquitin specific protease 41 0.023 0.2517 0.583
Loa Loa (eye worm) cytochrome P450 family protein 0.0294 0.3297 0.3273
Onchocerca volvulus 0.0187 0.199 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0063 0.0483 0.0271
Onchocerca volvulus 0.0055 0.0396 0.1098
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0555 0.0314
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0195 0.2083 0.4284
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0396 0.0362
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0199 0.0359
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0066 0.0518 0.5
Loa Loa (eye worm) hypothetical protein 0.023 0.2517 0.2491
Brugia malayi Protein kinase domain containing protein 0.0376 0.4284 0.4236
Brugia malayi Cytochrome P450 family protein 0.0294 0.3297 0.3241
Trypanosoma brucei cytochrome P450, putative 0.0294 0.3297 0.7435
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0453 0.0957
Brugia malayi follicle stimulating hormone receptor 0.0477 0.5507 0.5469
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0195 0.2083 1
Echinococcus multilocularis musashi 0.0055 0.0396 0.0823
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0195 0.2083 0.5762
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0195 0.2083 0.5762
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0195 0.2083 1
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0376 0.4284 1
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0066 0.0518 0.0219
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.007 0.057 0.0496
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0066 0.0518 0.0219
Mycobacterium leprae Conserved hypothetical protein 0.0195 0.2083 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0555 0.0314
Loa Loa (eye worm) cytochrome P450 family protein 0.0294 0.3297 0.3273
Brugia malayi cytochrome P450 0.0195 0.2083 0.2017
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0376 0.4284 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0555 0.0314
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0195 0.2083 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.023 0.2517 0.583
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0059 0.0434 0.0913
Schistosoma mansoni lamin 0.0055 0.0396 0.0924
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.023 0.2517 0.5478
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0059 0.0434 0.5
Trichomonas vaginalis CMGC family protein kinase 0.0162 0.1686 0.3251
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0195 0.2083 1
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.007 0.057 0.0496
Schistosoma mansoni hypothetical protein 0.0039 0.0199 0.0465
Echinococcus multilocularis 0.0195 0.2083 0.4806
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0195 0.2083 0.4368
Loa Loa (eye worm) hypothetical protein 0.0371 0.4232 0.4212
Leishmania major cytochrome p450-like protein 0.0195 0.2083 0.4284
Schistosoma mansoni loxhd1 0.0039 0.0199 0.0465
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0083 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0518 0.0219
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0195 0.2083 0.5762
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0066 0.0518 0.1112
Schistosoma mansoni cytochrome P450 0.0195 0.2083 0.4863
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.023 0.2517 0.5411
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0195 0.2083 0.5762
Schistosoma mansoni rab6-interacting 0.0039 0.0199 0.0465
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0162 0.1686 0.335
Echinococcus multilocularis Polycystic kidney disease protein 0.0039 0.0199 0.0359
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0434 0.0575
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0376 0.4284 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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