Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0274 | 0.3457 | 0.3457 |
Echinococcus multilocularis | tumor protein p63 | 0.0401 | 0.54 | 0.5378 |
Echinococcus granulosus | tumor protein p63 | 0.0401 | 0.54 | 0.5378 |
Schistosoma mansoni | tar DNA-binding protein | 0.0274 | 0.3457 | 0.3457 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0408 | 0.5495 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0078 | 0.0459 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0459 | 0.0561 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0702 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0408 | 0.5495 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.0459 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0274 | 0.3457 | 0.629 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0078 | 0.0459 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0101 | 0.0801 | 0.1457 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0408 | 0.5495 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0274 | 0.3457 | 0.3457 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0078 | 0.0459 | 0.5 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.0459 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0069 | 0.0313 | 0.057 |
Schistosoma mansoni | tar DNA-binding protein | 0.0274 | 0.3457 | 0.3457 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0078 | 0.0459 | 0.0459 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.0459 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0274 | 0.3457 | 0.6179 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0801 | 0.1201 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0274 | 0.3457 | 0.629 |
Loa Loa (eye worm) | TAR-binding protein | 0.0274 | 0.3457 | 0.6179 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0702 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0274 | 0.3457 | 0.6179 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.0459 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.0459 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0101 | 0.0801 | 0.1201 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0313 | 0.0288 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.2884 | 0.5106 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.0459 | 0.5 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0078 | 0.0459 | 0.0415 |
Echinococcus multilocularis | tar DNA binding protein | 0.0274 | 0.3457 | 0.3426 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0237 | 0.2884 | 0.2851 |
Brugia malayi | RNA binding protein | 0.0274 | 0.3457 | 0.629 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0101 | 0.0801 | 0.1457 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.023 | 0.2785 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0274 | 0.3457 | 0.3426 |
Schistosoma mansoni | hypothetical protein | 0.0069 | 0.0313 | 0.0313 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0059 | 0.016 | 0.016 |
Brugia malayi | hypothetical protein | 0.0237 | 0.2884 | 0.5248 |
Onchocerca volvulus | 0.0059 | 0.016 | 1 | |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0078 | 0.0459 | 0.0415 |
Schistosoma mansoni | tar DNA-binding protein | 0.0274 | 0.3457 | 0.3457 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0237 | 0.2884 | 0.2851 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.0459 | 0.5 |
Brugia malayi | Probable ClpP-like protease | 0.0078 | 0.0459 | 0.0836 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0078 | 0.0459 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | Antimicrobial activity against Escherichia coli by disc diffusion method | ChEMBL. | 21774474 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.