Detailed information for compound 1031564

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 351.192 | Formula: C10H16Cl2N8O2
  • H donors: 6 H acceptors: 2 LogP: 0.35 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: NC(=N)N/N=C/c1ccc(c(c1O)O)/C=N/NC(=N)N.Cl.Cl
  • InChi: 1S/C10H14N8O2.2ClH/c11-9(12)17-15-3-5-1-2-6(8(20)7(5)19)4-16-18-10(13)14;;/h1-4,19-20H,(H4,11,12,17)(H4,13,14,18);2*1H/b15-3+,16-4+;;
  • InChiKey: XZTACSXHMZGOLU-APRSGQKDSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica cysteine protease, putative 0.001 0.028 0.1883
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.1127 1
Onchocerca volvulus 0.0019 0.1127 0.2759
Brugia malayi MH1 domain containing protein 0.0008 0.0104 0.0104
Brugia malayi calpain 7 0.0022 0.1374 0.1374
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0022 0.1374 0.2277
Echinococcus granulosus calpain 5 0.0022 0.1374 0.214
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.1127 0.7567
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.4137 0.6443
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.1127 1
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.1127 0.1756
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.055 0.4878
Echinococcus multilocularis calpain A 0.0077 0.6421 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.149 1
Brugia malayi Cathepsin L-like precursor 0.0019 0.1127 0.1127
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0073 0.6079 0.9467
Brugia malayi calpain family protein 1 0.0073 0.6079 0.6079
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.6035 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.149 0.149
Plasmodium vivax vivapain-2 0.0019 0.1127 0.8204
Onchocerca volvulus Cathepsin L homolog 0.0019 0.1127 0.2759
Echinococcus granulosus cathepsin l1 0.0013 0.055 0.0856
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.6035 1
Loa Loa (eye worm) ctsf protein 0.0019 0.1127 0.1127
Plasmodium vivax calpain, putative 0.0022 0.1374 1
Echinococcus multilocularis cysteine protease 0.0019 0.1127 0.1756
Echinococcus granulosus calpain A 0.0077 0.6421 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.1127 1
Onchocerca volvulus Cathepsin L homolog 0.0019 0.1127 0.2759
Mycobacterium ulcerans hypothetical protein 0.0023 0.149 1
Schistosoma mansoni calpain (C02 family) 0.0022 0.1374 0.214
Onchocerca volvulus 0.0019 0.1127 0.2759
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0104 0.0162
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.1127 0.1127
Plasmodium vivax vivapain-2 0.0019 0.1127 0.8204
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.1127 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0022 0.1374 0.2277
Trypanosoma brucei calpain-like protein, putative 0.0022 0.1374 0.2277
Brugia malayi calpain family protein 1 0.0073 0.6079 0.6079
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.149 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.149 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.028 0.0437
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.149 1
Schistosoma mansoni smad1 5 8 and 0.0008 0.0104 0.0162
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0022 0.1374 0.2277
Schistosoma mansoni smad 0.0008 0.0104 0.0162
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.149 1
Brugia malayi Papain family cysteine protease containing protein 0.001 0.028 0.028
Schistosoma mansoni Mername-AA248 (C02 family) 0.0022 0.1374 0.214
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.087 0.5844
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0022 0.1374 0.2277
Schistosoma mansoni tar DNA-binding protein 0.0072 0.5967 0.9293
Schistosoma mansoni tar DNA-binding protein 0.0072 0.5967 0.9293
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.149 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.149 0.149
Brugia malayi MH1 domain containing protein 0.0008 0.0104 0.0104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.1127 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.1127 1
Echinococcus granulosus cathepsin L 0.001 0.028 0.0437
Echinococcus multilocularis calpain 5 0.0022 0.1374 0.214
Onchocerca volvulus 0.0019 0.1127 0.2759
Echinococcus multilocularis tar DNA binding protein 0.0072 0.5967 0.9293
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0022 0.1374 0.2277
Brugia malayi Cathepsin L-like precursor 0.0019 0.1127 0.1127
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.6035 1
Entamoeba histolytica cysteine protease, putative 0.001 0.028 0.1883
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.1127 0.7567
Entamoeba histolytica cysteine protease, putative 0.001 0.028 0.1883
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.055 0.4878
Brugia malayi Papain family cysteine protease containing protein 0.001 0.028 0.028
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.6035 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.028 0.2488
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0022 0.1374 0.2277
Leishmania major cathepsin L-like protease 0.0019 0.1127 0.1868
Plasmodium falciparum cysteine proteinase falcipain 1 0.001 0.028 0.2488
Entamoeba histolytica cysteine proteinase 2 0.001 0.028 0.1883
Echinococcus multilocularis smad 0.0008 0.0104 0.0162
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.1127 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0104 0.0162
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.1127 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.1127 1
Echinococcus granulosus calpain 7 C02 family 0.0022 0.1374 0.214
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0104 0.0104
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0957 0.6962
Trypanosoma cruzi cysteine protease, putative 0.001 0.028 0.0465
Toxoplasma gondii cathepsin CPL 0.0019 0.1127 1
Trypanosoma cruzi cysteine peptidase, putative 0.0073 0.6035 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0104 0.0162
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.1127 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.6035 1
Leishmania major kinesin, putative 0.0022 0.1374 0.2277
Echinococcus multilocularis calpain 0.0022 0.1374 0.214
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.028 0.0437
Trypanosoma brucei calpain-like protein, putative 0.0022 0.1374 0.2277
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.1127 0.1756
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0957 0.6421
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.1127 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.6079 0.6079
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.1127 0.1868
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0022 0.1374 0.2277
Trypanosoma cruzi cysteine peptidase, putative 0.001 0.028 0.0465
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.1127 1
Brugia malayi Smad1 0.0008 0.0104 0.0104
Onchocerca volvulus 0.0019 0.1127 0.2759
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.1127 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.4137 0.6443
Loa Loa (eye worm) hypothetical protein 0.0017 0.0957 0.0957
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0077 0.6421 1
Trypanosoma cruzi cysteine peptidase, putative 0.0073 0.6035 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.4137 0.4137
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.028 0.0437
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.6035 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.149 0.149
Brugia malayi Cathepsin L-like precursor 0.0019 0.1127 0.1127
Loa Loa (eye worm) hypothetical protein 0.0017 0.0957 0.0957
Echinococcus multilocularis calpain family protein 1, d 0.0051 0.4086 0.6363
Loa Loa (eye worm) cysteine protease 0.0019 0.1127 0.1127
Entamoeba histolytica cysteine protease, putative 0.001 0.028 0.1883
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.149 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0957 0.0957
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0066 0.5457 0.9043
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0022 0.1374 0.2277
Entamoeba histolytica cysteine proteinase 1, putative 0.001 0.028 0.1883
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.4137 0.6443
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.087 0.5844
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.6035 1
Entamoeba histolytica cysteine proteinase, putative 0.001 0.028 0.1883
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.1127 0.1756
Entamoeba histolytica cysteine protease, putative 0.001 0.028 0.1883
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.4137 0.6443
Loa Loa (eye worm) Smad1 0.0008 0.0104 0.0104
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.6035 1
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0022 0.1374 0.2277
Schistosoma mansoni calpain C (C02 family) 0.0022 0.1374 0.214
Entamoeba histolytica cysteine proteinase, putative 0.001 0.028 0.1883
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0077 0.6421 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0957 0.0957
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.149 0.2468
Echinococcus granulosus tar DNA binding protein 0.0072 0.5967 0.9293
Entamoeba histolytica cysteine protease, putative 0.001 0.028 0.1883
Loa Loa (eye worm) calpain 0.0022 0.1374 0.1374
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.149 1
Entamoeba histolytica cysteine protease, putative 0.001 0.028 0.1883
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.001 0.028 0.0465
Leishmania major cathepsin L-like protease 0.0019 0.1127 0.1868
Brugia malayi AMP-binding enzyme family protein 0.0023 0.149 0.149
Loa Loa (eye worm) calpain 5 0.0022 0.1374 0.1374
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.1127 1
Entamoeba histolytica cysteine proteinase, putative 0.0013 0.055 0.3691
Brugia malayi RNA recognition motif domain containing protein 0.0072 0.5967 0.5967
Echinococcus granulosus calpain 0.0022 0.1374 0.214
Brugia malayi MH2 domain containing protein 0.0008 0.0104 0.0104
Schistosoma mansoni tar DNA-binding protein 0.0072 0.5967 0.9293
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.1127 1
Entamoeba histolytica cysteine protease, putative 0.001 0.028 0.1883
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.1127 0.1756
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.149 1
Entamoeba histolytica cysteine protease, putative 0.001 0.028 0.1883
Onchocerca volvulus 0.0019 0.1127 0.2759
Schistosoma mansoni smad1 5 8 and 0.0008 0.0104 0.0162
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.149 0.2468
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.1127 1
Echinococcus multilocularis cysteine protease 0.0019 0.1127 0.1756
Leishmania major cathepsin L-like protease 0.0073 0.6035 1
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.1127 0.1756
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.1127 0.1127
Entamoeba histolytica cysteine proteinase, putative 0.001 0.028 0.1883
Entamoeba histolytica cysteine protease, putative 0.001 0.028 0.1883
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.1127 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.001 0.028 0.0465
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.4137 0.6443
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0957 0.5
Brugia malayi AMP-binding enzyme family protein 0.0023 0.149 0.149
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.028 0.2488
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.1127 1
Trypanosoma brucei kinesin, putative 0.0022 0.1374 0.2277
Plasmodium vivax vivapain-1 0.001 0.028 0.2041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.6035 1
Leishmania major cysteine peptidase A (CPA) 0.0019 0.1127 0.1868
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.149 1
Trypanosoma cruzi cysteine proteinase, putative 0.001 0.028 0.0465
Echinococcus granulosus Smad4 0.0008 0.0104 0.0162
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.1127 0.1127
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.4137 0.6443
Trypanosoma brucei calpain-like protein, putative 0.0022 0.1374 0.2277
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.1127 1
Brugia malayi MH2 domain containing protein 0.0008 0.0104 0.0104
Leishmania major cathepsin L-like protease 0.0073 0.6035 1
Schistosoma mansoni smad1 5 8 and 0.0008 0.0104 0.0162
Schistosoma mansoni tar DNA-binding protein 0.0072 0.5967 0.9293
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.1127 1
Trypanosoma brucei calpain-like protein, putative 0.0022 0.1374 0.2277
Loa Loa (eye worm) hypothetical protein 0.0051 0.4086 0.4086
Entamoeba histolytica cysteine protease, putative 0.001 0.028 0.1883
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.087 0.5844
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.1127 0.1756
Loa Loa (eye worm) fibroinase 0.0019 0.1127 0.1127
Brugia malayi Cathepsin L-like precursor 0.0019 0.1127 0.1127
Trypanosoma cruzi cruzipain precursor, putative 0.0073 0.6035 1
Loa Loa (eye worm) RNA binding protein 0.0072 0.5967 0.5967
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.6035 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0077 0.6421 1
Onchocerca volvulus 0.0051 0.4086 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0957 0.0957
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.1127 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.001 0.028 0.0465
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.1127 0.1756
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.1127 1
Trypanosoma cruzi kinesin, putative 0.0022 0.1374 0.2277
Entamoeba histolytica cysteine protease, putative 0.0019 0.1127 0.7567
Schistosoma mansoni cathepsin F (C01 family) 0.0013 0.055 0.0856
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0104 0.0162
Echinococcus multilocularis cathepsin L 0.001 0.028 0.0437
Echinococcus granulosus calpain A 0.0022 0.1374 0.214
Entamoeba histolytica calpain large subunit domain III containing protein 0.0022 0.1374 0.9224
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.149 1
Brugia malayi TAR-binding protein 0.0072 0.5967 0.5967
Onchocerca volvulus 0.0013 0.055 0.1346
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0022 0.1374 0.2277
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0022 0.1374 0.2277
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0022 0.1374 0.2277
Brugia malayi Cathepsin L-like cysteine proteinase 0.0013 0.055 0.055
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.4137 0.4137
Plasmodium vivax vivapain-3 0.001 0.028 0.2041
Brugia malayi RNA binding protein 0.0072 0.5967 0.5967
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.1127 0.1756
Loa Loa (eye worm) hypothetical protein 0.0019 0.1127 0.1127
Loa Loa (eye worm) hypothetical protein 0.0013 0.055 0.055
Loa Loa (eye worm) hypothetical protein 0.0023 0.149 0.149
Leishmania major cathepsin L-like protease 0.0073 0.6035 1
Trypanosoma cruzi cysteine proteinase, putative 0.001 0.028 0.0465
Leishmania major cathepsin L-like protease 0.0019 0.1127 0.1868
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.1127 1
Echinococcus granulosus cathepsin l1 0.0019 0.1127 0.1756
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.149 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0057 0.4611 0.764
Leishmania major cathepsin L-like protease 0.0019 0.1127 0.1868
Schistosoma mansoni calpain-7 (C02 family) 0.0022 0.1374 0.214
Loa Loa (eye worm) hypothetical protein 0.0013 0.055 0.055
Loa Loa (eye worm) hypothetical protein 0.0051 0.4086 0.4086
Loa Loa (eye worm) transcription factor SMAD2 0.0116 1 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.149 0.2468
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0072 0.5967 0.5967
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.1127 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.6079 0.6079
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.1127 1
Trypanosoma brucei antigen, putative 0.0022 0.1374 0.2277
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0104 0.0104
Echinococcus multilocularis calpain 7 (C02 family) 0.0022 0.1374 0.214
Trypanosoma cruzi cysteine peptidase, putative 0.0073 0.6035 1
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0957 0.8486
Brugia malayi Cathepsin L-like precursor 0.0013 0.055 0.055
Echinococcus granulosus cysteine protease 0.001 0.028 0.0437
Entamoeba histolytica cysteine proteinase, putative 0.001 0.028 0.1883
Onchocerca volvulus 0.0019 0.1127 0.2759
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.6035 1
Brugia malayi cathepsin L-like precursor 0.0013 0.055 0.055
Schistosoma mansoni Smad4 0.0008 0.0104 0.0162
Brugia malayi Cathepsin L-like precursor 0.0019 0.1127 0.1127
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.1127 1
Echinococcus multilocularis Smad4 0.0008 0.0104 0.0162
Brugia malayi Cathepsin L-like precursor 0.0019 0.1127 0.1127
Leishmania major cathepsin L-like protease 0.0019 0.1127 0.1868
Onchocerca volvulus 0.0019 0.1127 0.2759
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.1127 1
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0077 0.6421 1
Schistosoma mansoni calpain-7 (C02 family) 0.0022 0.1374 0.214
Schistosoma mansoni tar DNA-binding protein 0.0072 0.5967 0.9293
Loa Loa (eye worm) calpain family protein 1 0.0073 0.6079 0.6079
Plasmodium vivax unspecified product 0.001 0.028 0.2041
Entamoeba histolytica cysteine protease, putative 0.001 0.028 0.1883
Loa Loa (eye worm) hypothetical protein 0.0013 0.055 0.055
Entamoeba histolytica cysteine protease, putative 0.001 0.028 0.1883
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.149 1
Loa Loa (eye worm) TAR-binding protein 0.0072 0.5967 0.5967
Brugia malayi Cathepsin L-like precursor 0.0013 0.055 0.055
Onchocerca volvulus 0.0023 0.149 0.3646
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0022 0.1374 0.2277
Onchocerca volvulus Cathepsin F homolog 0.0019 0.1127 0.2759
Loa Loa (eye worm) calpain family protein 1 0.0051 0.4086 0.4086
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.4137 0.6443
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0104 0.0162
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.149 1
Echinococcus multilocularis hypothetical protein 0.0022 0.1374 0.214
Entamoeba histolytica protein kinase, putative 0.0022 0.1374 0.9224
Echinococcus granulosus smad 0.0008 0.0104 0.0162
Echinococcus granulosus cathepsin L cysteine protease 0.001 0.028 0.0437
Brugia malayi calpain 5 0.0022 0.1374 0.1374
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.087 0.5844
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0022 0.1374 0.2277
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.1127 1
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0022 0.1374 0.2277
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0957 0.6421
Trypanosoma cruzi kinesin, putative 0.0022 0.1374 0.2277

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 26.4 uM Inhibition of LPS-induced production of nitric oxide in murine J774.A1 cells ChEMBL. 16377188
IC50 (functional) = 59.1 uM Inhibition of induction of NFkappaB by LPS in HEK293 cells cotransfected with TLR4, CD14 and MD2 ChEMBL. 16377188

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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