Detailed information for compound 103158

Basic information

Technical information
  • TDR Targets ID: 103158
  • Name: N-[3-ethoxy-4-(1,3-oxazol-5-yl)phenyl]-5-phen yl-1,3-oxazol-2-amine
  • MW: 347.367 | Formula: C20H17N3O3
  • H donors: 1 H acceptors: 2 LogP: 4.29 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cc(ccc1c1cnco1)Nc1ncc(o1)c1ccccc1
  • InChi: 1S/C20H17N3O3/c1-2-24-17-10-15(8-9-16(17)19-11-21-13-25-19)23-20-22-12-18(26-20)14-6-4-3-5-7-14/h3-13H,2H2,1H3,(H,22,23)
  • InChiKey: GSHOVVNHCBFGHB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(3-ethoxy-4-oxazol-5-yl-phenyl)-5-phenyl-oxazol-2-amine
  • N-[3-ethoxy-4-(5-oxazolyl)phenyl]-5-phenyl-2-oxazolamine
  • (3-ethoxy-4-oxazol-5-yl-phenyl)-(5-phenyloxazol-2-yl)amine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens IMP (inosine 5'-monophosphate) dehydrogenase 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium berghei inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma brucei GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania mexicana guanosine monophosphate reductase Get druggable targets OG5_126887 All targets in OG5_126887
Neospora caninum hypothetical protein Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma brucei gambiense inosine-5-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma congolense GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Cryptosporidium parvum inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania infantum inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania braziliensis inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania mexicana inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania major inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania major guanosine monophosphate reductase Get druggable targets OG5_126887 All targets in OG5_126887
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Loa Loa (eye worm) IMP dehydrogenase 1 Get druggable targets OG5_126887 All targets in OG5_126887
Candida albicans N terminus of Inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium yoelii inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania donovani GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania donovani inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Cryptosporidium hominis inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Theileria parva Inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Schistosoma japonicum ko:K00088 IMP dehydrogenase [EC1.1.1.205], putative Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma brucei gambiense inosine-5-monophosphate dehydrogenase,IMP dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Candida albicans guanosine nucleotide biosynthesis Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania infantum guanosine monophosphate reductase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Toxoplasma gondii IMP dehydrogenas Get druggable targets OG5_126887 All targets in OG5_126887
Candida albicans guanosine nucleotide biosynthesis Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena Get druggable targets OG5_126887 All targets in OG5_126887
Candida albicans N terminus of Inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein Get druggable targets OG5_126887 All targets in OG5_126887
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 Get druggable targets OG5_126887 All targets in OG5_126887
Schistosoma mansoni inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania braziliensis guanosine monophosphate reductase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Babesia bovis inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium knowlesi inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0045 0.0053 0.0151
Schistosoma mansoni amine oxidase 0.0044 0.0046 0.0004
Brugia malayi SWIRM domain containing protein 0.0235 0.1939 0.1939
Brugia malayi Latrophilin receptor protein 2 0.0077 0.0376 0.0376
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0056 0.0163 0.0122
Schistosoma mansoni furin-1 (S08 family) 0.0456 0.4129 0.4104
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0095 0.0549 1
Brugia malayi hypothetical protein 0.0056 0.0163 0.0163
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0056 0.0163 0.1411
Echinococcus multilocularis 0.0044 0.0046 0.0005
Loa Loa (eye worm) hypothetical protein 0.0216 0.1757 0.1757
Toxoplasma gondii subtilisin SUB12 0.0045 0.0053 0.0091
Plasmodium vivax aspartyl proteinase, putative 0.0128 0.0879 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.0163
Toxoplasma gondii subtilisin SUB10 0.0045 0.0053 0.0091
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0045 0.0053 0.0151
Loa Loa (eye worm) hypothetical protein 0.0044 0.0046 0.0046
Toxoplasma gondii subtilisin SUB4 0.0045 0.0053 0.0091
Echinococcus multilocularis membrane bound transcription factor site 1 0.0045 0.0053 0.0015
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0128 0.0879 0.0841
Trichomonas vaginalis hypothetical protein 0.0203 0.1619 0.2667
Brugia malayi Eukaryotic aspartyl protease family protein 0.0056 0.0163 0.0163
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0095 0.0549 1
Trypanosoma cruzi GMP reductase 0.0095 0.0549 1
Trichomonas vaginalis conserved hypothetical protein 0.0203 0.1619 0.2667
Brugia malayi celfurPC protein 0.0845 0.799 0.799
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0637 0.5924 1
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0045 0.0053 0.0015
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0095 0.0549 1
Trichomonas vaginalis conserved hypothetical protein 0.0203 0.1619 0.2667
Loa Loa (eye worm) subtilase 0.0045 0.0053 0.0053
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0247 0.2063 0.3423
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0056 0.0163 0.0122
Toxoplasma gondii aspartyl protease ASP3 0.0056 0.0163 0.1411
Loa Loa (eye worm) hypothetical protein 0.0411 0.3685 0.3685
Plasmodium falciparum plasmepsin X 0.0056 0.0163 0.1411
Plasmodium falciparum subtilisin-like protease 1 0.0045 0.0053 0.0091
Brugia malayi Myb-like DNA-binding domain containing protein 0.0178 0.1377 0.1377
Echinococcus multilocularis protoporphyrinogen oxidase 0.0044 0.0046 0.0005
Schistosoma mansoni site-1 peptidase (S08 family) 0.0045 0.0053 0.0012
Loa Loa (eye worm) hypothetical protein 0.0167 0.1266 0.1266
Chlamydia trachomatis protoporphyrinogen oxidase 0.0044 0.0046 0.5
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0056 0.0163 0.0122
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0095 0.0549 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0247 0.2063 0.3423
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0128 0.0879 0.0879
Plasmodium vivax plasmepsin IV, putative 0.0128 0.0879 1
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0247 0.2063 0.203
Echinococcus granulosus lysine specific histone demethylase 1A 0.0216 0.1757 0.1723
Toxoplasma gondii aspartyl protease ASP1 0.0128 0.0879 1
Brugia malayi Pepsin A precursor 0.0056 0.0163 0.0163
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.005 0.0103 0.1134
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0637 0.5924 0.5907
Echinococcus granulosus lysine specific histone demethylase 1A 0.0044 0.0046 0.0004
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0077 0.0376 0.0376
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0045 0.0053 0.0151
Plasmodium falciparum plasmepsin VI 0.0128 0.0879 1
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0045 0.0053 0.0151
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0045 0.0056 0.0199
Plasmodium vivax aspartyl protease, putative 0.0056 0.0163 0.1411
Onchocerca volvulus 0.0235 0.1939 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0247 0.2063 0.3423
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0045 0.0053 0.0012
Loa Loa (eye worm) hypothetical protein 0.0216 0.1757 0.1757
Echinococcus multilocularis 0.0845 0.799 1
Brugia malayi hypothetical protein 0.0056 0.0163 0.0163
Trypanosoma cruzi GMP reductase 0.0095 0.0549 1
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0044 0.0046 0.0004
Echinococcus granulosus Furin 1 0.0247 0.2063 0.203
Echinococcus granulosus GPCR family 2 0.0077 0.0376 0.0336
Toxoplasma gondii subtilisin SUB6 0.0045 0.0053 0.0091
Brugia malayi aspartic protease BmAsp-2, identical 0.0056 0.0163 0.0163
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0045 0.0053 0.0151
Brugia malayi latrophilin 2 splice variant baaae 0.0167 0.1266 0.1266
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0045 0.0053 0.0012
Loa Loa (eye worm) hypothetical protein 0.0045 0.0053 0.0053
Schistosoma mansoni hypothetical protein 0.0077 0.0376 0.0336
Giardia lamblia High cysteine membrane protein Group 2 0.0389 0.347 1
Echinococcus multilocularis GPCR, family 2 0.0077 0.0376 0.0421
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0637 0.5924 0.7401
Toxoplasma gondii IMP dehydrogenas 0.0095 0.0549 0.6042
Loa Loa (eye worm) reprolysin 0.0044 0.0042 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0203 0.1619 0.2667
Plasmodium falciparum plasmepsin III 0.0056 0.0163 0.1411
Plasmodium falciparum plasmepsin V 0.0056 0.0163 0.1411
Toxoplasma gondii subtilisin SUB5 0.0045 0.0053 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0203 0.1619 0.2667
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0056 0.0163 0.0122
Loa Loa (eye worm) hypothetical protein 0.0062 0.0227 0.0227
Plasmodium vivax aspartyl proteinase, putative 0.0056 0.0163 0.1411
Schistosoma mansoni hypothetical protein 0.0077 0.0376 0.0336
Schistosoma mansoni cathepsin D (A01 family) 0.0312 0.2706 0.2675
Plasmodium falciparum plasmepsin IX 0.0056 0.0163 0.1411
Loa Loa (eye worm) proprotein convertase 2 0.0247 0.2063 0.2063
Loa Loa (eye worm) latrophilin receptor protein 2 0.0077 0.0376 0.0376
Loa Loa (eye worm) hypothetical protein 0.0044 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.1047 1 1
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0203 0.1619 0.2667
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0996 0.9487 0.9487
Plasmodium vivax plasmepsin V, putative 0.0056 0.0163 0.1411
Plasmodium falciparum plasmepsin IV 0.0128 0.0879 1
Plasmodium vivax aspartyl protease, putative 0.0056 0.0163 0.1411
Plasmodium vivax aspartyl protease, putative 0.0056 0.0163 0.1411
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0829 0.7831 0.7822
Toxoplasma gondii subtilisin SUB2 0.0045 0.0053 0.0091
Plasmodium vivax subtilisin-like protease 2, putative 0.0045 0.0053 0.0091
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0056 0.0163 0.0122
Trichomonas vaginalis conserved hypothetical protein 0.0203 0.1619 0.2667
Loa Loa (eye worm) endoprotease bli-4 0.1047 1 1
Brugia malayi hypothetical protein 0.0044 0.0046 0.0046
Brugia malayi Subtilase family protein 0.0045 0.0053 0.0053
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0247 0.2063 0.3423
Loa Loa (eye worm) hypothetical protein 0.0178 0.1377 0.1377
Plasmodium falciparum subtilisin-like protease 2 0.0045 0.0053 0.0091
Mycobacterium leprae Possible secreted protease 0.0045 0.0053 0.0151
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0056 0.0163 0.0122
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0056 0.0163 0.0163
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.005 0.0103 0.1134
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0095 0.0549 1
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0045 0.0056 0.0199
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0095 0.0549 0.0639
Toxoplasma gondii subtilisin SUB1 0.0045 0.0053 0.0091
Schistosoma mansoni hypothetical protein 0.0167 0.1266 0.1229
Loa Loa (eye worm) hypothetical protein 0.0044 0.0042 0.0042
Loa Loa (eye worm) IMP dehydrogenase 1 0.0095 0.0549 0.0549
Onchocerca volvulus CoRest homolog 0.0183 0.1429 0.737
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0829 0.7831 0.98
Echinococcus multilocularis Furin 1 0.0247 0.2063 0.2543
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0216 0.1757 0.2158
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0056 0.0163 0.0122
Schistosoma mansoni hypothetical protein 0.0203 0.1619 0.1584
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0095 0.0549 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0056 0.0163 0.0122
Leishmania major inosine-5-monophosphate dehydrogenase 0.0095 0.0549 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0376 0.0376
Onchocerca volvulus 0.0045 0.0053 0.0275
Onchocerca volvulus 0.0056 0.0163 0.0843
Toxoplasma gondii subtilisin SUB9 0.0045 0.0053 0.0091
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.1047 1 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0247 0.2063 0.3423
Toxoplasma gondii aspartyl protease 0.0056 0.0163 0.1411
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0203 0.1619 0.2667
Brugia malayi proprotein convertase 2 0.0658 0.6139 0.6139
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0244 0.2033 0.2033
Trichomonas vaginalis conserved hypothetical protein 0.0203 0.1619 0.2667
Schistosoma mansoni amine oxidase 0.0044 0.0046 0.0004
Loa Loa (eye worm) hypothetical protein 0.0996 0.9487 0.9487
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0128 0.0879 0.0841
Leishmania major subtilisin-like serine peptidase 0.0045 0.0053 0.0151
Echinococcus granulosus adam 0.0057 0.0175 0.0134
Schistosoma mansoni site-1 peptidase (S08 family) 0.0045 0.0053 0.0012
Plasmodium vivax subtilisin-like serine protease, putative 0.0045 0.0053 0.0091
Leishmania major guanosine monophosphate reductase 0.0095 0.0549 1
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0095 0.0549 0.0549
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0045 0.0053 0.0151
Trypanosoma cruzi subtilisin peptidase 0.0045 0.0053 0.0151
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0247 0.2063 0.3423
Loa Loa (eye worm) hypothetical protein 0.0128 0.0879 0.0879
Plasmodium falciparum subtilisin-like protease 3 0.0045 0.0053 0.0091
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0045 0.0053 0.0151
Loa Loa (eye worm) hypothetical protein 0.0183 0.1429 0.1429
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0045 0.0053 0.0151
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0045 0.0053 0.0012
Schistosoma mansoni hypothetical protein 0.0077 0.0376 0.0336
Toxoplasma gondii subtilisin SUB7 0.0045 0.0053 0.0091
Plasmodium falciparum plasmepsin VIII, putative 0.0056 0.0163 0.1411
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0057 0.0175 0.0134
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0077 0.0376 0.0336
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0089 0.0494 0.5373
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.0163
Brugia malayi neuroendocrine convertase 1 precursor 0.0658 0.6139 0.6139
Brugia malayi aspartic protease BmAsp-1, identical 0.0056 0.0163 0.0163
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0203 0.1619 0.2667
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0089 0.0494 0.5373
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0045 0.0053 0.0053
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0077 0.0376 0.0421
Toxoplasma gondii subtilisin SUB11 0.0045 0.0053 0.0091
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0637 0.5924 1
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0045 0.0053 0.0053
Schistosoma mansoni hypothetical protein 0.0077 0.0376 0.0336
Trichomonas vaginalis conserved hypothetical protein 0.0203 0.1619 0.2667
Trichomonas vaginalis conserved hypothetical protein 0.0203 0.1619 0.2667
Echinococcus granulosus membrane bound transcription factor site 1 0.0045 0.0053 0.0012
Echinococcus multilocularis adam 0.0057 0.0175 0.0168
Trichomonas vaginalis conserved hypothetical protein 0.0203 0.1619 0.2667
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0095 0.0549 1
Plasmodium falciparum plasmepsin VII 0.0056 0.0163 0.1411
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0045 0.0053 0.0151
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0045 0.0053 0.0151
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0045 0.0053 0.0151
Echinococcus granulosus neuroendocrine convertase 2 0.0658 0.6139 0.6123
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0216 0.1757 0.1723
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0095 0.0549 0.051
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0095 0.0549 1
Schistosoma mansoni memapsin-2 (A01 family) 0.0857 0.811 0.8102
Brugia malayi hypothetical protein 0.0057 0.0175 0.0175
Trypanosoma brucei GMP reductase 0.0095 0.0549 1
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0045 0.0053 0.0151
Plasmodium falciparum plasmepsin II 0.0128 0.0879 1
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0089 0.0494 0.8892
Loa Loa (eye worm) hypothetical protein 0.0235 0.1939 0.1939
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0128 0.0879 0.1054
Plasmodium vivax subtilisin-like protease 1 0.0045 0.0053 0.0091
Brugia malayi amine oxidase, flavin-containing family protein 0.0062 0.0227 0.0227
Toxoplasma gondii subtilisin SUB8 0.0045 0.0053 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0203 0.1619 0.2667
Schistosoma mansoni cathepsin D (A01 family) 0.0312 0.2706 0.2675
Onchocerca volvulus 0.0056 0.0163 0.0843
Echinococcus granulosus furin 0.1047 1 1
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0095 0.0549 0.051
Loa Loa (eye worm) aspartyl protease 6 0.0056 0.0163 0.0163
Echinococcus multilocularis neuroendocrine convertase 2 0.0658 0.6139 0.7671
Brugia malayi Calcitonin receptor-like protein seb-1 0.0244 0.2033 0.2033
Trichomonas vaginalis conserved hypothetical protein 0.0203 0.1619 0.2667
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0128 0.0879 0.1407
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0128 0.0879 1
Plasmodium falciparum plasmepsin I 0.0128 0.0879 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 10 uM Inhibition of inosine-5'-monophosphate dehydrogenase 2. ChEMBL. 12781195
IC50 (binding) > 10 uM Inhibition of inosine-5'-monophosphate dehydrogenase 2. ChEMBL. 12781195

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.