Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | dna polymerase kappa | 0.002 | 0.1004 | 0.3047 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0033 | 0.2097 | 0.4775 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.1004 | 0.1904 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.002 | 0.1004 | 0.3047 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.1004 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.1004 | 0.1904 |
Mycobacterium ulcerans | DNA polymerase IV | 0.002 | 0.1004 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.1004 | 0.1904 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.002 | 0.1004 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.002 | 0.1004 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.002 | 0.1004 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.1004 | 0.1904 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.002 | 0.1004 | 0.5 |
Echinococcus multilocularis | dna polymerase kappa | 0.002 | 0.1004 | 0.3047 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0126 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.1004 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.1004 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.1004 | 0.1904 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.002 | 0.1004 | 0.3047 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.002 | 0.1004 | 0.3047 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.002 | 0.1004 | 0.1004 |
Giardia lamblia | DINP protein human, muc B family | 0.002 | 0.1004 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.1004 | 0.1904 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.002 | 0.1004 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.1004 | 0.1904 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0033 | 0.2097 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.1004 | 0.1904 |
Schistosoma mansoni | DNA polymerase eta | 0.0047 | 0.3293 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0047 | 0.3293 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.1004 | 0.1904 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.002 | 0.1004 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0033 | 0.2097 | 0.4775 |
Leishmania major | DNA polymerase eta, putative | 0.0047 | 0.3293 | 1 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.002 | 0.1004 | 0.3047 |
Trypanosoma brucei | unspecified product | 0.002 | 0.1004 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.1004 | 0.1904 |
Echinococcus multilocularis | dna polymerase eta | 0.0047 | 0.3293 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0047 | 0.3293 | 0.3293 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0047 | 0.3293 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.3293 | 0.3293 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.002 | 0.1004 | 0.1004 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0047 | 0.3293 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0126 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 22.5 uM | Inhibition of human recombinant GST-tagged AKR1C3 expressed in Escherichia coli BL21 | ChEMBL. | 19237229 |
IC50 (binding) | = 62.1 uM | Inhibition of human recombinant GST-tagged AKR1C1 expressed in Escherichia coli BL21 | ChEMBL. | 19237229 |
Inhibition (binding) | = 52.9 % | Inhibition of human recombinant GST-tagged AKR1C1 expressed in Escherichia coli BL21 at 100 uM | ChEMBL. | 19237229 |
Inhibition (binding) | = 83.9 % | Inhibition of human recombinant GST-tagged AKR1C3 expressed in Escherichia coli BL21 at 100 uM | ChEMBL. | 19237229 |
Ki (binding) | = 20.5 uM | Inhibition of human recombinant GST-tagged AKR1C3 expressed in Escherichia coli BL21 | ChEMBL. | 19237229 |
Ki (binding) | = 30.5 uM | Inhibition of human recombinant GST-tagged AKR1C1 expressed in Escherichia coli BL21 | ChEMBL. | 19237229 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.