Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dopamine receptor D2 | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D3 | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D4 | Starlite/ChEMBL | References |
Bos taurus | Dopamine D1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | 5-hydroxytryptamine receptor 1, putative | Get druggable targets OG5_132667 | All targets in OG5_132667 |
Schistosoma japonicum | 5-hydroxytryptamine receptor, putative | Get druggable targets OG5_132667 | All targets in OG5_132667 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | dopamine receptor D3 | 400 aa | 392 aa | 19.9 % |
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Dopamine D1 receptor | 446 aa | 398 aa | 33.9 % |
Onchocerca volvulus | Dopamine D1 receptor | 446 aa | 359 aa | 21.4 % | |
Loa Loa (eye worm) | hypothetical protein | Dopamine D1 receptor | 446 aa | 370 aa | 24.3 % |
Schistosoma mansoni | biogenic amine (5HT) receptor | Dopamine D1 receptor | 446 aa | 393 aa | 32.3 % |
Schistosoma japonicum | ko:K04145 dopamine receptor D2, putative | Dopamine D1 receptor | 446 aa | 373 aa | 27.1 % |
Schistosoma japonicum | ko:K04136 adrenergic receptor, alpha 1b, putative | Dopamine D1 receptor | 446 aa | 371 aa | 34.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0486 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0224 | 0 | 0.5 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0486 | 1 | 1 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0486 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 105 nM | In vitro displacement of [3H]-spiperone from the recombinant human dopamine receptor D2 short form expressed in CHO cells | ChEMBL. | 10987445 |
Ki (binding) | = 105 nM | In vitro displacement of [3H]-spiperone from the recombinant human dopamine receptor D2 short form expressed in CHO cells | ChEMBL. | 10987445 |
Ki (binding) | = 195 nM | In vitro displacement of [3H]-spiperone from the recombinant human dopamine receptor D2L stably expressed in CHO cells | ChEMBL. | 10987445 |
Ki (binding) | = 195 nM | In vitro displacement of [3H]-spiperone from the recombinant human dopamine receptor D2L stably expressed in CHO cells | ChEMBL. | 10987445 |
Ki (binding) | = 205 nM | In vitro displacement of [3H]-spiperone from the cloned human dopamine receptor D3 stably expressed in CHO cells | ChEMBL. | 10987445 |
Ki (binding) | = 205 nM | In vitro displacement of [3H]-spiperone from the cloned human dopamine receptor D3 stably expressed in CHO cells | ChEMBL. | 10987445 |
Ki (binding) | = 400 nM | In vitro displacement of [3H]-spiperone from the recombinant human dopamine receptor D4 expressed in CHO cells | ChEMBL. | 10987445 |
Ki (binding) | = 400 nM | In vitro displacement of [3H]-spiperone from the recombinant human dopamine receptor D4 expressed in CHO cells | ChEMBL. | 10987445 |
Ki (binding) | = 4500 nM | In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane | ChEMBL. | 10987445 |
Ki (binding) | = 4500 nM | In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane | ChEMBL. | 10987445 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.