Detailed information for compound 103253

Basic information

Technical information
  • TDR Targets ID: 103253
  • Name: [1,3]thiazolo[5,4-d]pyrimidin-7-amine
  • MW: 152.177 | Formula: C5H4N4S
  • H donors: 1 H acceptors: 3 LogP: 0.65 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1ncnc2c1ncs2
  • InChi: 1S/C5H4N4S/c6-4-3-5(8-1-7-4)10-2-9-3/h1-2H,(H2,6,7,8)
  • InChiKey: XLQTXFKCBDQZSN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • thiazolo[5,4-d]pyrimidin-7-amine
  • 7-thiazolo[5,4-d]pyrimidinamine
  • thiazolo[5,4-d]pyrimidin-7-ylamine
  • [1,3]thiazolo[4,5-e]pyrimidin-7-amine
  • thiazolo[4,5-e]pyrimidin-7-amine
  • 7-thiazolo[4,5-e]pyrimidinamine
  • thiazolo[4,5-e]pyrimidin-7-ylamine
  • 2846-90-4
  • NSC513224

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0814 0.08 0.3074
Echinococcus multilocularis membrane bound transcription factor site 1 0.018 0.0153 0.0206
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.018 0.0153 0.2108
Giardia lamblia Neurogenic locus Notch protein precursor 0.0208 0.0182 0.1054
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0118 0.009 0.012
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0722 0.0706 1
Echinococcus granulosus Furin 1 0.0994 0.0984 0.1333
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0327 0.0304 1
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0187 0.0161 0.21
Schistosoma mansoni hypothetical protein 0.0031 0.0001 0.0003
Plasmodium vivax aspartyl protease, putative 0.0114 0.0086 0.0974
Onchocerca volvulus 0.0048 0.0019 0.0147
Brugia malayi EGF-like domain containing protein 0.0208 0.0182 0.0181
Plasmodium vivax subtilisin-like serine protease, putative 0.018 0.0153 0.1953
Brugia malayi aspartic protease BmAsp-2, identical 0.0114 0.0086 0.0085
Loa Loa (eye worm) hypothetical protein 0.1246 0.1242 0.1241
Plasmodium vivax plasmepsin V, putative 0.0347 0.0324 0.4435
Mycobacterium ulcerans polyketide synthase 0.0092 0.0063 0.0854
Echinococcus granulosus c-Jun N-terminal kinases 0.0242 0.0216 0.0291
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0121 0.0093 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.018 0.0153 0.0555
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0994 0.0984 0.3789
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.018 0.0153 0.2365
Toxoplasma gondii aspartyl protease ASP1 0.0187 0.0161 0.21
Schistosoma mansoni hypothetical protein 0.0046 0.0016 0.0028
Mycobacterium leprae Polyketide synthase Pks13 0.013 0.0103 0.1265
Brugia malayi transcriptional regulator, Sir2 family protein 0.0327 0.0304 0.0303
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0195 0.0169 0.2272
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.0722 0.0706 1
Loa Loa (eye worm) hypothetical protein 0.0487 0.0467 0.0466
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.0644 0.0627 0.5
Loa Loa (eye worm) endoprotease bli-4 0.4207 0.4264 0.4263
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2557 0.2579 1
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0051 0.0021 0.0241
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0118 0.009 0.012
Loa Loa (eye worm) hypothetical protein 0.0208 0.0182 0.0181
Toxoplasma gondii type I fatty acid synthase, putative 0.0092 0.0063 0.0688
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.018 0.0153 0.0555
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0092 0.0063 0.0608
Schistosoma mansoni memapsin-2 (A01 family) 0.1748 0.1754 0.3009
Loa Loa (eye worm) sirtuin 4 0.0048 0.0019 0.0018
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.018 0.0153 0.0263
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0139 0.0111 0.0149
Schistosoma mansoni chromatin regulatory protein sir2 0.0327 0.0304 0.0521
Schistosoma mansoni ATP-binding cassette transporter 0.0103 0.0075 0.0128
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0994 0.0984 0.3789
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.0722 0.0706 1
Loa Loa (eye worm) transcriptional regulator 0.0048 0.0019 0.0018
Onchocerca volvulus 0.0083 0.0055 0.2321
Plasmodium falciparum plasmepsin IV 0.0187 0.0161 0.2063
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0086 0.0058 0.0823
Loa Loa (eye worm) integrin beta-2 0.9827 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0011 0.0141
Brugia malayi Kelch motif family protein 0.1525 0.1527 0.1526
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0118 0.009 0.012
Brugia malayi ADAMTS-like protease 0.0166 0.0139 0.0139
Echinococcus granulosus furin 0.4207 0.4264 0.5784
Echinococcus granulosus membrane bound transcription factor site 1 0.018 0.0153 0.0206
Loa Loa (eye worm) hypothetical protein 0.0046 0.0016 0.0016
Onchocerca volvulus 0.018 0.0153 0.8264
Loa Loa (eye worm) hypothetical protein 0.0147 0.0119 0.0119
Toxoplasma gondii subtilisin SUB7 0.018 0.0153 0.1991
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.018 0.0153 0.2365
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0048 0.0019 0.0121
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0284 0.026 0.0446
Plasmodium falciparum plasmepsin VII 0.0114 0.0086 0.0974
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0114 0.0086 0.0147
Brugia malayi SWIRM domain containing protein 0.0145 0.0118 0.0118
Schistosoma mansoni protein kinase 0.0139 0.0111 0.0191
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0092 0.0063 0.0854
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0092 0.0063 0.0914
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.009 0.0061 0.0884
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.018 0.0153 0.0206
Schistosoma mansoni hypothetical protein 0.0031 0.0001 0.0003
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.018 0.0153 0.0555
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0134 0.0107 0.0183
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0008
Trypanosoma brucei unspecified product 0.0034 0.0004 0.0048
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0814 0.08 0.3074
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0086 0.0058 0.0823
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.009 0.0061 0.0824
Brugia malayi Glutamate receptor 2 precursor 0.01 0.0072 0.0071
Schistosoma mansoni chromatin regulatory protein sir2 0.0048 0.0019 0.0033
Mycobacterium leprae Possible secreted protease 0.018 0.0153 0.2108
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0048 0.0019 0.0024
Mycobacterium leprae conserved hypothetical protein 0.0078 0.0049 0.0377
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.1495 0.1496 0.2028
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0994 0.0984 0.3789
Loa Loa (eye worm) hypothetical protein 0.0114 0.0086 0.0085
Echinococcus granulosus adam 0.058 0.0562 0.076
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0327 0.0304 0.4293
Schistosoma mansoni integrin alpha-ps 0.0523 0.0504 0.0864
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0327 0.0304 0.041
Mycobacterium tuberculosis Probable transcriptional regulatory protein NrdR 0.0078 0.0049 0.0691
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0119 0.0092 0.0122
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0001 0.0001
Plasmodium falciparum plasmepsin III 0.0114 0.0086 0.0974
Trichomonas vaginalis conserved hypothetical protein 0.018 0.0153 0.0555
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0187 0.0161 0.0276
Plasmodium vivax subtilisin-like protease 1 0.018 0.0153 0.1953
Brugia malayi proprotein convertase 2 0.2644 0.2668 0.2668
Schistosoma mansoni ADAMTS14 peptidase (M12 family) 0.0079 0.005 0.0086
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.0722 0.0706 1
Echinococcus multilocularis serine:threonine protein kinase N2 0.0077 0.0049 0.0064
Schistosoma mansoni chromatin regulatory protein sir2 0.0048 0.0019 0.0033
Brugia malayi Glutamate receptor 1 precursor 0.01 0.0072 0.0071
Echinococcus multilocularis integrin alpha ps 0.0946 0.0935 0.1267
Echinococcus multilocularis integrin beta 2 0.7251 0.737 1
Toxoplasma gondii subtilisin SUB8 0.018 0.0153 0.1991
Onchocerca volvulus 0.0145 0.0118 0.6146
Mycobacterium tuberculosis Polyketide synthase Pks13 0.013 0.0103 0.1549
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0118 0.009 0.012
Brugia malayi hypothetical protein 0.0114 0.0086 0.0085
Schistosoma mansoni glutamate receptor kainate 0.01 0.0072 0.0123
Schistosoma mansoni chromatin regulatory protein sir2 0.0327 0.0304 0.0521
Echinococcus granulosus glutamate NMDA receptor subunit 0.036 0.0337 0.0456
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0011 0.0141
Echinococcus granulosus neuroendocrine convertase 2 0.2644 0.2668 0.3619
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0056 0.0027 0.0262
Plasmodium falciparum subtilisin-like protease 3 0.018 0.0153 0.1953
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0994 0.0984 0.1688
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.2557 0.2579 0.3498
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0334 0.031 0.0419
Brugia malayi Reprolysin 0.0166 0.014 0.0139
Mycobacterium ulcerans Sir2-like regulatory protein 0.0048 0.0019 0.0136
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0001 0.0001
Giardia lamblia High cysteine protein 0.0208 0.0182 0.1054
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0011 0.0141
Mycobacterium ulcerans Type I modular polyketide synthase 0.0086 0.0058 0.0762
Loa Loa (eye worm) hypothetical protein 0.0134 0.0107 0.0106
Schistosoma mansoni protein kinase 0.0139 0.0111 0.0191
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.0722 0.0706 0.0957
Loa Loa (eye worm) kelch domain-containing protein family protein 0.1525 0.1527 0.1526
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.2557 0.2579 0.3498
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0011 0.0141
Trypanosoma cruzi subtilisin peptidase 0.018 0.0153 0.205
Loa Loa (eye worm) TK/ALK protein kinase 0.0046 0.0016 0.0016
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0092 0.0063 0.0854
Onchocerca volvulus 0.0208 0.0182 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.018 0.0153 0.0555
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0048 0.0019 0.026
Brugia malayi metalloprotease 0.0079 0.005 0.0049
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.0644 0.0627 1
Brugia malayi EGF-like domain containing protein 0.0208 0.0182 0.0181
Loa Loa (eye worm) hypothetical protein 0.018 0.0153 0.0153
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0114 0.0086 0.0147
Schistosoma mansoni chromatin regulatory protein sir2 0.0048 0.0019 0.0033
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.018 0.0153 0.0555
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0048 0.0019 0.0201
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0887 0.0875 0.0875
Loa Loa (eye worm) glutamate receptor 2 0.01 0.0072 0.0071
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.018 0.0153 0.0555
Brugia malayi hypothetical protein 0.151 0.1511 0.1511
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.007 0.0041 0.0555
Trichomonas vaginalis conserved hypothetical protein 0.0814 0.08 0.3074
Brugia malayi Eukaryotic aspartyl protease family protein 0.0114 0.0086 0.0085
Echinococcus multilocularis epidermal growth factor receptor 0.0114 0.0086 0.0115
Loa Loa (eye worm) transcriptional regulator 0.0327 0.0304 0.0303
Loa Loa (eye worm) hypothetical protein 0.0079 0.005 0.0049
Loa Loa (eye worm) hypothetical protein 0.0067 0.0038 0.0038
Echinococcus multilocularis integrin alpha 3 0.131 0.1307 0.1771
Brugia malayi Protein kinase domain containing protein 0.0046 0.0016 0.0016
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0059 0.003 0.0039
Schistosoma mansoni integrin beta subunit 0.574 0.5829 1
Loa Loa (eye worm) subtilase 0.018 0.0153 0.0153
Mycobacterium ulcerans NAD-dependent deacetylase 0.0048 0.0019 0.0136
Brugia malayi endoprotease bli-4 precursor 0.4207 0.4264 0.4263
Loa Loa (eye worm) reprolysin 0.0284 0.026 0.0259
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0064 0.0035 0.0461
Schistosoma mansoni hypothetical protein 0.0031 0.0001 0.0003
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0118 0.009 0.012
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0114 0.0086 0.0147
Brugia malayi Pepsin A precursor 0.0114 0.0086 0.0085
Loa Loa (eye worm) hypothetical protein 0.165 0.1654 0.1653
Loa Loa (eye worm) hypothetical protein 0.0187 0.0161 0.016
Giardia lamblia Furin precursor putative serine protease 0.0814 0.08 0.5053
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0059 0.003 0.0039
Schistosoma mansoni chromatin regulatory protein sir2 0.0327 0.0304 0.0521
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0134 0.0107 0.0143
Brugia malayi Integrin alpha pat-2 precursor 0.1769 0.1776 0.1775
Schistosoma mansoni hypothetical protein 0.0119 0.0092 0.0157
Schistosoma mansoni cathepsin D (A01 family) 0.0374 0.0352 0.0604
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0092 0.0063 0.0914
Toxoplasma gondii aspartyl protease ASP3 0.0114 0.0086 0.1016
Trichomonas vaginalis conserved hypothetical protein 0.0814 0.08 0.3074
Brugia malayi hypothetical protein 0.0046 0.0016 0.0016
Echinococcus multilocularis dna polymerase kappa 0.004 0.0011 0.0012
Mycobacterium tuberculosis Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) 0.0231 0.0206 0.3215
Brugia malayi neuroendocrine convertase 1 precursor 0.2644 0.2668 0.2668
Loa Loa (eye worm) hypothetical protein 0.0031 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.4207 0.4264 0.4263
Loa Loa (eye worm) hypothetical protein 0.0064 0.0035 0.0034
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.0722 0.0706 0.1212
Brugia malayi Subtilase family protein 0.018 0.0153 0.0153
Brugia malayi amine oxidase, flavin-containing family protein 0.0039 0.0009 0.0008
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0048 0.0019 0.0024
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0086 0.0058 0.0057
Toxoplasma gondii subtilisin SUB9 0.018 0.0153 0.1991
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.007 0.0069
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0059 0.003 0.0039
Schistosoma mansoni glutamate receptor kainate 0.01 0.0072 0.0123
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0083 0.0055 0.0778
Schistosoma mansoni hypothetical protein 0.0031 0.0001 0.0003
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0197 0.0171 0.2309
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0011 0.0141
Mycobacterium leprae Probable polyketide synthase Pks1 0.0092 0.0063 0.0608
Giardia lamblia hypothetical protein 0.0208 0.0182 0.1054
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0118 0.009 0.012
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0011 0.0141
Trichomonas vaginalis conserved hypothetical protein 0.0814 0.08 0.3074
Loa Loa (eye worm) hypothetical protein 0.0208 0.0182 0.0181
Trichomonas vaginalis conserved hypothetical protein 0.0814 0.08 0.3074
Toxoplasma gondii hypothetical protein 0.0208 0.0182 0.2407
Echinococcus multilocularis glutamate receptor 2 0.0059 0.003 0.0038
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.018 0.0153 0.2315
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0327 0.0304 0.1141
Schistosoma mansoni hypothetical protein 0.0119 0.0092 0.0157
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.0644 0.0627 0.2399
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0208 0.0182 0.0667
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0187 0.0161 0.0585
Schistosoma mansoni hypothetical protein 0.0067 0.0038 0.0066
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.0722 0.0706 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0994 0.0984 0.3789
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0327 0.0304 0.4212
Echinococcus granulosus adam 17 protease 0.0118 0.009 0.012
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.018 0.0153 0.0206
Schistosoma mansoni glutamate receptor kainate 0.01 0.0072 0.0123
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.0722 0.0706 0.0706
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0119 0.0092 0.0091
Schistosoma mansoni integrin alpha 0.1769 0.1776 0.3046
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.0722 0.0706 0.0957
Echinococcus granulosus nmda type glutamate receptor 0.0149 0.0122 0.0163
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0114 0.0086 0.0147
Echinococcus multilocularis neuroendocrine convertase 2 0.2644 0.2668 0.3619
Plasmodium falciparum plasmepsin VIII, putative 0.0114 0.0086 0.0974
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.0722 0.0706 1
Brugia malayi ribonucleoside-diphosphate reductase large chain, putative 0.0722 0.0706 0.0706
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0195 0.0169 0.2272
Brugia malayi angiogenesis inhibito 0.0166 0.0139 0.0139
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.036 0.0337 0.0456
Echinococcus multilocularis disintegrin and metalloproteinase 0.0118 0.009 0.012
Leishmania major silent information regulator 2, putative 0.0327 0.0304 0.4141
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0118 0.009 0.012
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0284 0.026 0.0351
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.018 0.0153 0.0555
Trichomonas vaginalis conserved hypothetical protein 0.018 0.0153 0.0555
Trichomonas vaginalis hypothetical protein 0.0208 0.0182 0.0667
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0187 0.0161 0.0216
Plasmodium vivax aspartyl proteinase, putative 0.0187 0.0161 0.2063
Loa Loa (eye worm) apoptosis regulator protein 0.0119 0.0092 0.0091
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0048 0.0019 0.0024
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0195 0.0169 0.2381
Schistosoma mansoni furin-1 (S08 family) 0.183 0.1837 0.3152
Schistosoma mansoni glutamate receptor AMPA 0.01 0.0072 0.0123
Toxoplasma gondii type I fatty acid synthase, putative 0.0064 0.0035 0.0272
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.018 0.0153 0.0555
Toxoplasma gondii subtilisin SUB5 0.018 0.0153 0.1991
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.018 0.0153 0.0153
Schistosoma mansoni site-1 peptidase (S08 family) 0.018 0.0153 0.0263
Brugia malayi aspartic protease BmAsp-1, identical 0.0114 0.0086 0.0085
Echinococcus multilocularis integrin alpha ps 0.0423 0.0401 0.0543
Toxoplasma gondii subtilisin SUB11 0.018 0.0153 0.1991
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0048 0.0019 0.0033
Giardia lamblia Tenascin-X 0.0208 0.0182 0.1054
Trichomonas vaginalis conserved hypothetical protein 0.0814 0.08 0.3074
Echinococcus multilocularis protein kinase c epsilon type 0.0084 0.0056 0.0074
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0048 0.0019 0.0033
Loa Loa (eye worm) transcriptional regulator 0.0048 0.0019 0.0018
Schistosoma mansoni chromatin regulatory protein sir2 0.0048 0.0019 0.0033
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.018 0.0153 0.0555
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0187 0.0161 0.016
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0034 0.0004 0.0007
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0083 0.0055 0.0054
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0048 0.0019 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0011 0.0141
Loa Loa (eye worm) integrin alpha pat-2 0.2529 0.2551 0.255
Echinococcus multilocularis glutamate receptor 2 0.01 0.0072 0.0095
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.007 0.0069
Loa Loa (eye worm) hypothetical protein 0.0114 0.0086 0.0085
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0187 0.0161 0.0216
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.018 0.0153 0.0555
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0086 0.0058 0.0829
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.009 0.0061 0.0183
Plasmodium falciparum plasmepsin I 0.0187 0.0161 0.2063
Loa Loa (eye worm) hypothetical protein 0.0401 0.0379 0.0378
Schistosoma mansoni hypothetical protein 0.0046 0.0016 0.0028
Echinococcus granulosus glutamate receptor 2 0.0059 0.003 0.0038
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.018 0.0153 0.0555
Plasmodium vivax subtilisin-like protease 2, putative 0.018 0.0153 0.1953
Plasmodium falciparum subtilisin-like protease 2 0.018 0.0153 0.1953
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.018 0.0153 0.0555
Brugia malayi transcriptional regulator, Sir2 family protein 0.0048 0.0019 0.0018
Brugia malayi Stress-activated protein kinase jnk-1 0.0242 0.0216 0.0216
Schistosoma mansoni glutamate receptor NMDA 0.036 0.0337 0.0579
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0284 0.026 0.0446
Schistosoma mansoni site-1 peptidase (S08 family) 0.018 0.0153 0.0263
Echinococcus granulosus dna polymerase kappa 0.004 0.0011 0.0012
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.018 0.0153 0.2365
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0086 0.0058 0.0762
Loa Loa (eye worm) hypothetical protein 0.0284 0.026 0.0259
Mycobacterium ulcerans Type I modular polyketide synthase 0.0086 0.0058 0.0762
Plasmodium falciparum subtilisin-like protease 1 0.018 0.0153 0.1953
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0327 0.0304 0.1141
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0994 0.0984 0.3789
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.018 0.0153 0.0555
Echinococcus multilocularis fibrillin 2 0.0208 0.0182 0.0245
Loa Loa (eye worm) hypothetical protein 0.0041 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0119 0.0092 0.0091
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0242 0.0216 0.0291
Echinococcus multilocularis NMDA receptor 0.0059 0.003 0.0039
Loa Loa (eye worm) hypothetical protein 0.0166 0.0139 0.0139
Echinococcus multilocularis Furin 1 0.0994 0.0984 0.1333
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.0644 0.0627 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0114 0.0086 0.0147
Echinococcus granulosus lysine specific histone demethylase 1A 0.0134 0.0107 0.0143
Plasmodium falciparum plasmepsin V 0.0347 0.0324 0.4435
Echinococcus multilocularis glutamate receptor 2 0.0118 0.009 0.012
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.018 0.0153 0.0555
Toxoplasma gondii histone deacetylase SIR2-like 0.0048 0.0019 0.0047
Plasmodium vivax aspartyl protease, putative 0.0114 0.0086 0.0974
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0011 0.0141
Loa Loa (eye worm) hypothetical protein 0.0145 0.0118 0.0118
Echinococcus granulosus integrin beta 2 0.7251 0.737 1
Leishmania major subtilisin-like serine peptidase 0.018 0.0153 0.1953
Loa Loa (eye worm) hypothetical protein 0.1346 0.1344 0.1343
Trichomonas vaginalis conserved hypothetical protein 0.0814 0.08 0.3074
Onchocerca volvulus 0.0155 0.0128 0.6752
Schistosoma mansoni protein kinase 0.0139 0.0111 0.0191
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1289 0.1285 0.2205
Echinococcus granulosus integrin alpha ps 0.0946 0.0935 0.1267
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.018 0.0153 0.0555
Schistosoma mansoni glutamate receptor NMDA 0.0118 0.009 0.0154
Trypanosoma brucei subtilisin peptidase 0.018 0.0153 0.2162
Plasmodium falciparum plasmepsin IX 0.0114 0.0086 0.0974
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0118 0.009 0.012
Schistosoma mansoni serine/threonine protein kinase 0.0084 0.0056 0.0096
Echinococcus multilocularis adam 0.058 0.0562 0.076
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0069 0.004 0.0474
Echinococcus granulosus integrin alpha ps 0.0423 0.0401 0.0543
Toxoplasma gondii histone deacetylase SIR2 0.0048 0.0019 0.0047
Loa Loa (eye worm) acyl carrier protein 0.0041 0.0012 0.0011
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0048 0.0019 0.0033
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0048 0.0019 0.0033
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0048 0.0019 0.0033
Brugia malayi transcriptional regulator, Sir2 family protein 0.0048 0.0019 0.0018
Echinococcus granulosus protein kinase c epsilon type 0.0084 0.0056 0.0074
Echinococcus granulosus epidermal growth factor receptor 0.0114 0.0086 0.0115
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0048 0.0019 0.0033
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0092 0.0063 0.0914
Schistosoma mansoni hypothetical protein 0.0423 0.0401 0.0688
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.018 0.0153 0.0555
Trichomonas vaginalis conserved hypothetical protein 0.0814 0.08 0.3074
Echinococcus multilocularis 0.3393 0.3433 0.4657
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0114 0.0086 0.0085
Mycobacterium ulcerans thioesterase TesA 0.0074 0.0046 0.0568
Echinococcus granulosus fibrillin 2 0.0208 0.0182 0.0245
Loa Loa (eye worm) hypothetical protein 0.0046 0.0016 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0011 0.0141
Plasmodium falciparum plasmepsin II 0.0187 0.0161 0.2063
Loa Loa (eye worm) hypothetical protein 0.0134 0.0107 0.0106
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.4207 0.4264 0.7315
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0114 0.0086 0.1016
Onchocerca volvulus 0.0114 0.0086 0.42
Toxoplasma gondii subtilisin SUB6 0.018 0.0153 0.1991
Loa Loa (eye worm) hypothetical protein 0.0523 0.0504 0.0503
Loa Loa (eye worm) angiogenesis inhibito 0.0079 0.005 0.0049
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.018 0.0153 0.2365
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.018 0.0153 0.0555
Mycobacterium ulcerans polyketide synthase Pks13 0.013 0.0103 0.1493
Echinococcus granulosus MAM 0.0046 0.0016 0.002
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0814 0.08 0.3074
Echinococcus multilocularis fibrillin 1 0.0208 0.0182 0.0245
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0814 0.08 0.3074
Loa Loa (eye worm) hypothetical protein 0.0046 0.0016 0.0016
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0284 0.026 0.0351
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0069 0.004 0.0474
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0001 0.0001
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0118 0.009 0.012
Loa Loa (eye worm) hypothetical protein 0.0047 0.0018 0.0017
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0242 0.0216 0.0216
Brugia malayi hypothetical protein 0.0372 0.0349 0.0349
Giardia lamblia Hypothetical protein 0.0327 0.0304 0.1841
Loa Loa (eye worm) glutamate receptor 1 0.01 0.0072 0.0071
Trichomonas vaginalis hypothetical protein 0.0814 0.08 0.3074
Trichomonas vaginalis conserved hypothetical protein 0.0814 0.08 0.3074
Toxoplasma gondii subtilisin SUB1 0.018 0.0153 0.1991
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0234 0.0209 0.0358
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0059 0.003 0.0039
Schistosoma mansoni hypothetical protein 0.0814 0.08 0.1373
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0058 0.0029 0.0189
Giardia lamblia High cysteine membrane protein Group 2 0.1563 0.1565 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0149 0.0122 0.0163
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.018 0.0153 0.0555
Giardia lamblia Tenascin-37 0.0208 0.0182 0.1054
Echinococcus multilocularis MAM 0.0046 0.0016 0.002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.018 0.0153 0.0555
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.0722 0.0706 1
Echinococcus granulosus glutamate receptor subunit protein glur 0.0059 0.003 0.0039
Loa Loa (eye worm) hypothetical protein 0.0208 0.0182 0.0181
Loa Loa (eye worm) hypothetical protein 0.0166 0.0139 0.0139
Trichomonas vaginalis conserved hypothetical protein 0.0814 0.08 0.3074
Plasmodium vivax aspartyl proteinase, putative 0.0114 0.0086 0.0974
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.018 0.0153 0.0153
Onchocerca volvulus Fatty acid synthase homolog 0.0161 0.0134 0.7094
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0048 0.0019 0.0121
Mycobacterium ulcerans Type I modular polyketide synthase 0.0086 0.0058 0.0762
Giardia lamblia High cysteine protein 0.0208 0.0182 0.1054
Brugia malayi ADAM-TS Spacer 1 family protein 0.0166 0.0139 0.0139
Trichomonas vaginalis conserved hypothetical protein 0.0814 0.08 0.3074
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0118 0.009 0.012
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0994 0.0984 0.3789
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0048 0.0019 0.0033
Echinococcus granulosus fibrillin 1 0.0208 0.0182 0.0245
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0139 0.0111 0.0149
Giardia lamblia Tenascin-like 0.0208 0.0182 0.1054
Mycobacterium ulcerans polyketide synthase Pks9 0.0056 0.0027 0.0262
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0011 0.0141
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0069 0.004 0.0218
Toxoplasma gondii aspartyl protease 0.0114 0.0086 0.1016
Toxoplasma gondii subtilisin SUB12 0.018 0.0153 0.1991
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0092 0.0063 0.0608
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0119 0.0092 0.0122
Schistosoma mansoni hypothetical protein 0.0059 0.003 0.0051
Schistosoma mansoni serine/threonine protein kinase 0.0242 0.0216 0.0371
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0114 0.0086 0.0147
Plasmodium falciparum plasmepsin X 0.0114 0.0086 0.0974
Brugia malayi celfurPC protein 0.3393 0.3433 0.3433
Brugia malayi protein kinase C II. 0.0084 0.0056 0.0055
Loa Loa (eye worm) hypothetical protein 0.0118 0.009 0.0089
Onchocerca volvulus 0.0114 0.0086 0.42
Loa Loa (eye worm) proprotein convertase 2 0.0994 0.0984 0.0983
Chlamydia trachomatis glutamine binding protein 0.009 0.0061 0.0183
Echinococcus granulosus disintegrin and metalloproteinase 0.0118 0.009 0.012
Plasmodium vivax plasmepsin IV, putative 0.0187 0.0161 0.2063
Giardia lamblia Neurogenic locus notch-like protein 0.0208 0.0182 0.1054
Brugia malayi Furin-like cysteine rich region family protein 0.0114 0.0086 0.0086
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.018 0.0153 0.0555
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.018 0.0153 0.205
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0048 0.0019 0.0024
Toxoplasma gondii aspartyl protease ASP5 0.0233 0.0208 0.2779
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0004 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.018 0.0153 0.0555
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0334 0.031 0.0419
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2557 0.2579 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.018 0.0153 0.0555
Schistosoma mansoni dihydroceramide desaturase 0.0118 0.009 0.0154
Toxoplasma gondii subtilisin SUB4 0.018 0.0153 0.1991
Loa Loa (eye worm) aspartyl protease 6 0.0114 0.0086 0.0085
Mycobacterium ulcerans transcriptional regulator NrdR 0.0078 0.0049 0.0629
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.018 0.0153 0.0555
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0114 0.0086 0.0147
Plasmodium falciparum plasmepsin VI 0.0187 0.0161 0.2063
Brugia malayi hypothetical protein 0.0114 0.0086 0.0085
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0327 0.0304 1
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0084 0.0056 0.0055
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0166 0.0139 0.0138
Trichomonas vaginalis conserved hypothetical protein 0.018 0.0153 0.0555
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0048 0.0019 0.0024
Brugia malayi EGF-like domain containing protein 0.0208 0.0182 0.0181
Brugia malayi EGF-like domain containing protein 0.0208 0.0182 0.0181
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0074 0.0046 0.0314
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.1495 0.1496 0.2028
Loa Loa (eye worm) hypothetical protein 0.151 0.1511 0.1511
Echinococcus multilocularis protein jagged 2 0.0208 0.0182 0.0245
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.013 0.0103 0.1549
Giardia lamblia Tenascin precursor 0.0208 0.0182 0.1054
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0059 0.003 0.0039
Brugia malayi AMP-binding enzyme family protein 0.0083 0.0055 0.0054
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0327 0.0304 0.041
Mycobacterium tuberculosis Probable thioesterase TesA 0.0074 0.0046 0.063
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0114 0.0086 0.0147
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.018 0.0153 0.2108
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0401 0.0379 0.0378
Schistosoma mansoni cathepsin D (A01 family) 0.0374 0.0352 0.0604
Mycobacterium ulcerans thioesterase 0.0074 0.0046 0.0568
Loa Loa (eye worm) hypothetical protein 0.0088 0.0059 0.0059
Brugia malayi Disintegrin family protein 0.0118 0.009 0.0089
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0086 0.0058 0.0823
Plasmodium vivax aspartyl protease, putative 0.0114 0.0086 0.0974
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0086 0.0058 0.0829
Echinococcus granulosus glutamate receptor 2 0.0118 0.009 0.012
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0048 0.0019 0.0033
Schistosoma mansoni integrin alpha-ps 0.0882 0.087 0.1493
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.018 0.0153 0.0555
Schistosoma mansoni hypothetical protein 0.0119 0.0092 0.0157
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.0644 0.0627 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0019 0.0018
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0119 0.0092 0.0157
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0121 0.0093 0.0093
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.018 0.0153 0.0263
Loa Loa (eye worm) fatty acid synthase 0.0088 0.006 0.0059
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0086 0.0058 0.0514
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0372 0.0349 0.0599
Brugia malayi Integrin alpha cytoplasmic region family protein 0.1246 0.1242 0.1241
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0327 0.0304 0.4212
Toxoplasma gondii subtilisin SUB10 0.018 0.0153 0.1991
Echinococcus granulosus chromatin regulatory protein sir2 0.0327 0.0304 0.041
Echinococcus multilocularis nmda type glutamate receptor 0.0149 0.0122 0.0163
Brugia malayi NAD-dependent deacetylase SIRT1 0.0048 0.0019 0.0018
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0086 0.0058 0.0514
Echinococcus multilocularis chromatin regulatory protein sir2 0.0327 0.0304 0.041
Echinococcus multilocularis integrin alpha ps 0.0882 0.087 0.1179
Echinococcus granulosus integrin alpha 3 0.131 0.1307 0.1771
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.0722 0.0706 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0069 0.004 0.0744
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0059 0.003 0.0039
Schistosoma mansoni tyrosine kinase 0.0114 0.0086 0.0148
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.018 0.0153 0.2315
Mycobacterium ulcerans polyketide synthase 0.0086 0.0058 0.0762
Trypanosoma brucei SIR2-like protein 4, putative 0.0048 0.0019 0.026
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.018 0.0153 0.0555
Loa Loa (eye worm) hypothetical protein 0.0208 0.0182 0.0181
Echinococcus granulosus serine:threonine protein kinase N2 0.0069 0.004 0.0052
Toxoplasma gondii subtilisin SUB2 0.018 0.0153 0.1991
Loa Loa (eye worm) TK/EGFR protein kinase 0.0114 0.0086 0.0086
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0048 0.0019 0.0033
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.018 0.0153 0.0555
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.018 0.0153 0.2315
Loa Loa (eye worm) metalloprotease 0.0079 0.005 0.0049
Schistosoma mansoni apoptosis regulator bax 0.0119 0.0092 0.0157
Schistosoma mansoni glutamate receptor AMPA 0.01 0.0072 0.0123
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0011 0.0141

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 116.9 uM Inhibitory activity (IC50) against human phosphatidylinositol 4-kinase at the ATP binding site ChEMBL. 2165159
IC50 (binding) = 116.9 uM Inhibitory activity (IC50) against human phosphatidylinositol 4-kinase at the ATP binding site ChEMBL. 2165159
Ki (binding) = 80.6 uM Binding affinity (Ki) against human phosphatidylinositol 4-kinase ChEMBL. 2165159
Ki (binding) = 80.6 uM Binding affinity (Ki) against human phosphatidylinositol 4-kinase ChEMBL. 2165159

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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