Detailed information for compound 1032657

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 528.167 | Formula: C26H38ClNO4S2
  • H donors: 1 H acceptors: 2 LogP: 4.08 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(OCc1ccsc1C(=CCCN1CCCCC1C(=O)O)c1sccc1COC(C)C)C.Cl
  • InChi: 1S/C26H37NO4S2.ClH/c1-18(2)30-16-20-10-14-32-24(20)22(25-21(11-15-33-25)17-31-19(3)4)8-7-13-27-12-6-5-9-23(27)26(28)29;/h8,10-11,14-15,18-19,23H,5-7,9,12-13,16-17H2,1-4H3,(H,28,29);1H
  • InChiKey: RLSVAPXLXPVYMV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax SET domain protein, putative 0.0061 0.038 0.1981
Brugia malayi jmjC domain containing protein 0.0076 0.0508 0.1001
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0043 0.0128
Echinococcus multilocularis dna polymerase eta 0.002 0.0031 0.0038
Brugia malayi Matrixin family protein 0.0098 0.0695 0.1373
Trichomonas vaginalis set domain proteins, putative 0.0473 0.3906 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0131 0.0238
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0049 0.0072
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0032 0.0136 0.0262
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0219 0.0515
Trichomonas vaginalis Clan MA, family M48, Ste24 endopeptidase-like metallopeptidase 0.0045 0.0248 0.0587
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0049 0.0089
Onchocerca volvulus 0.0186 0.1448 0.3628
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0049 0.0072
Mycobacterium ulcerans hypothetical protein 0.0028 0.0104 0.0169
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.0022 0.0014
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0043 0.0046
Onchocerca volvulus 0.0473 0.3906 1
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0022 0.0033
Loa Loa (eye worm) hypothetical protein 0.0049 0.0281 0.0537
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0049 0.0089
Mycobacterium ulcerans pyruvate kinase 0.0072 0.048 0.0917
Brugia malayi Thioredoxin reductase 0.0032 0.0131 0.0252
Onchocerca volvulus 0.0028 0.0104 0.0144
Plasmodium vivax thioredoxin reductase, putative 0.0032 0.0131 0.061
Trypanosoma cruzi hypothetical protein, conserved 0.0186 0.1448 0.7847
Toxoplasma gondii ABC1 family protein 0.0186 0.1448 0.7847
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0112 0.0823 0.1628
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0131 0.0194
Schistosoma mansoni smad 0.0027 0.009 0.0133
Echinococcus granulosus polycomb protein SCMH1 0.0057 0.035 0.0519
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0031 0.0065
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.038 0.0564
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0231 0.184 1
Brugia malayi MH2 domain containing protein 0.0027 0.009 0.0171
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0019 0.0029
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0082 0.0345
Loa Loa (eye worm) hypothetical protein 0.0112 0.0823 0.1615
Echinococcus granulosus smad 0.0027 0.009 0.0133
Echinococcus multilocularis protein dispatched 1 0.0058 0.0355 0.0435
Loa Loa (eye worm) glutathione reductase 0.0032 0.0131 0.0237
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0072 0.0476 0.0753
Onchocerca volvulus 0.0032 0.0136 0.0226
Mycobacterium tuberculosis Conserved protein 0.0186 0.1448 0.1432
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0031 0.0065
Echinococcus multilocularis beta LACTamase domain containing family member 0.0186 0.1448 0.1773
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0049 0.0089
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0049 0.0282 0.1443
Brugia malayi metalloprotease disintegrin 16 with thrombospondin type I motif 0.0058 0.0354 0.0695
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0372 0.3042 0.3724
Echinococcus granulosus cpg binding protein 0.0062 0.0388 0.0576
Echinococcus multilocularis cpg binding protein 0.0062 0.0388 0.0475
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0049 0.0282 0.1443
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0294 0.036
Echinococcus multilocularis carbonic anhydrase II 0.0208 0.1637 0.2004
Mycobacterium leprae conserved hypothetical protein 0.0186 0.1448 0.2725
Leishmania major pyruvate kinase 0.0072 0.048 0.2528
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0372 0.3042 0.4511
Mycobacterium tuberculosis Probable lipase LipE 0.0186 0.1448 0.1432
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0372 0.3042 0.6037
Mycobacterium tuberculosis Conserved protein 0.0186 0.1448 0.1432
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0022 0.0027
Trichomonas vaginalis glucosylceramidase, putative 0.0214 0.1691 0.4301
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0112 0.0823 0.1628
Mycobacterium leprae PROBABLE HYDROLASE 0.0049 0.0281 0.0359
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0131 0.016
Toxoplasma gondii thioredoxin reductase 0.0032 0.0131 0.061
Schistosoma mansoni ap endonuclease 0.0019 0.0019 0.0029
Echinococcus multilocularis carbonic anhydrase 0.0112 0.0823 0.1007
Schistosoma mansoni carbonic anhydrase-related 0.0112 0.0823 0.122
Echinococcus multilocularis expressed conserved protein 0.0111 0.0809 0.099
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.008 0.0544 0.0526
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0072 0.0476 0.0457
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0171 0.1324 0.2473
Trypanosoma brucei metallo- peptidase, Clan M- Family M48 0.0045 0.0248 0.1254
Echinococcus multilocularis polycomb protein SCMH1 0.0057 0.035 0.0428
Schistosoma mansoni sex comb on midleg homolog 0.0057 0.035 0.0519
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0049 0.0072
Loa Loa (eye worm) transcription factor SMAD2 0.0392 0.3215 0.6374
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0044 0.0079
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0049 0.0072
Loa Loa (eye worm) matrixin family protein 0.0098 0.0695 0.136
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0022 0.0033
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.0219 0.1099
Plasmodium falciparum pyruvate kinase 0.0072 0.048 0.2528
Brugia malayi Matrixin family protein 0.004 0.0206 0.0402
Echinococcus granulosus adam 17 protease 0.0134 0.1008 0.1495
Loa Loa (eye worm) hypothetical protein 0.0068 0.0443 0.086
Echinococcus multilocularis CAAX prenyl protease 2 0.0061 0.0383 0.0469
Giardia lamblia Pyruvate kinase 0.0037 0.0179 0.0561
Plasmodium vivax glutathione reductase, putative 0.0032 0.0131 0.061
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0049 0.0072
Schistosoma mansoni sex comb on midleg homolog 0.0057 0.035 0.0519
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0186 0.1448 0.2147
Trichomonas vaginalis penicillin-binding protein, putative 0.0186 0.1448 0.3676
Loa Loa (eye worm) thioredoxin reductase 0.0032 0.0131 0.0237
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0019 0.0031
Echinococcus granulosus thioredoxin glutathione reductase 0.0032 0.0131 0.0194
Loa Loa (eye worm) hypothetical protein 0.0112 0.0823 0.1615
Echinococcus multilocularis lysine specific demethylase 5A 0.007 0.0464 0.0568
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0031 0.0065
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0033 0.0013
Loa Loa (eye worm) hypothetical protein 0.0118 0.087 0.1709
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0131 0.0252
Toxoplasma gondii CAAX metallo endopeptidase 0.0045 0.0248 0.1254
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0027 0.009 0.011
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.004
Echinococcus granulosus survival motor neuron protein 1 0.0158 0.1208 0.1791
Echinococcus granulosus carbonic anhydrase 0.0112 0.0823 0.122
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0104 0.0299
Echinococcus multilocularis pyruvate kinase 0.0037 0.0179 0.0219
Trypanosoma cruzi pyruvate kinase 2, putative 0.0072 0.048 0.2528
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0294 0.0436
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0031 0.0065
Echinococcus multilocularis smad 0.0027 0.009 0.011
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0186 0.1448 0.2848
Brugia malayi Matrixin family protein 0.004 0.0206 0.0402
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0372 0.3042 0.4511
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0282 0.0418
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.035 0.2856 0.7299
Echinococcus multilocularis Niemann Pick C1 protein 0.0169 0.1303 0.1595
Brugia malayi Pyruvate kinase, M2 isozyme 0.0072 0.048 0.0946
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0082 0.0345
Brugia malayi MAP kinase sur-1 0.0049 0.0282 0.0553
Echinococcus granulosus dnaJ subfamily B 0.0805 0.6744 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0043 0.0063
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0022 0.0027
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0049 0.0072
Brugia malayi MH1 domain containing protein 0.0027 0.009 0.0171
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0027 0.009 0.0133
Echinococcus multilocularis adam 0.0021 0.0043 0.0052
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0029 0.0036
Schistosoma mansoni hypothetical protein 0.0032 0.0136 0.0202
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0022 0.0021
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.035 0.2856 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0019 0.0024
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.038 0.1981
Echinococcus multilocularis caax prenyl protease 1 0.0045 0.0248 0.0303
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0372 0.3042 0.4511
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0022 0.0033
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0282 0.0676
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0049 0.0074
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0049 0.006
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0049 0.0282 0.1443
Trichomonas vaginalis glucosylceramidase, putative 0.031 0.2507 0.6402
Echinococcus granulosus dna polymerase eta 0.002 0.0031 0.0046
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0396 0.0587
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0049 0.0281 0.0551
Echinococcus granulosus mothers against decapentaplegic 5 0.0027 0.009 0.0133
Leishmania major hypothetical protein, conserved 0.0026 0.0082 0.0345
Loa Loa (eye worm) hypothetical protein 0.0112 0.0823 0.1615
Brugia malayi dihydrofolate reductase family protein 0.0605 0.5037 1
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0022 0.0033
Loa Loa (eye worm) hypothetical protein 0.004 0.0206 0.0387
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0231 0.184 1
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0104 0.0199
Echinococcus granulosus transcription factor btf3 0.0042 0.0219 0.0325
Brugia malayi Pyruvate kinase, muscle isozyme 0.0072 0.048 0.0946
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0022 0.0033
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0294 0.0436
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.008 0.0098
Trypanosoma cruzi CAAX prenyl protease 1, putative 0.0045 0.0248 0.1254
Echinococcus multilocularis microtubule associated protein 2 0.046 0.3792 0.4641
Entamoeba histolytica acyl-coA synthetase, putative 0.0028 0.0104 0.0299
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0049 0.006
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0028 0.0104 0.0085
Trichomonas vaginalis glucosylceramidase, putative 0.031 0.2507 0.6402
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.0131 0.061
Echinococcus multilocularis mothers against decapentaplegic 5 0.0027 0.009 0.011
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0024 0.0066 0.0097
Schistosoma mansoni smad1 5 8 and 0.0027 0.009 0.0133
Brugia malayi Peptidase family M48 containing protein 0.0045 0.0248 0.0485
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0112 0.0823 0.1628
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0049 0.006
Echinococcus granulosus dna polymerase kappa 0.002 0.0031 0.0046
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0031 0.0065
Loa Loa (eye worm) hypothetical protein 0.0021 0.0043 0.0063
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0112 0.0823 0.1628
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0049 0.0072
Onchocerca volvulus Pyruvate kinase homolog 0.0072 0.048 0.1118
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0049 0.0281 0.0417
Brugia malayi hypothetical protein 0.0158 0.1208 0.2393
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0065 0.0418 0.0822
Schistosoma mansoni zinc finger protein 0.0023 0.0055 0.0082
Loa Loa (eye worm) hypothetical protein 0.0022 0.0049 0.0074
Schistosoma mansoni coup transcription factor 0.0022 0.0049 0.0072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0049 0.0074
Brugia malayi hypothetical protein 0.0119 0.0877 0.1736
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0022 0.0033
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0022 0.0014
Brugia malayi mbt repeat family protein 0.0057 0.035 0.0688
Loa Loa (eye worm) hypothetical protein 0.0072 0.048 0.0932
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0186 0.1448 0.1432
Brugia malayi beta-lactamase family protein 0.0186 0.1448 0.287
Brugia malayi Matrixin family protein 0.004 0.0206 0.0402
Loa Loa (eye worm) hypothetical protein 0.0022 0.0049 0.0074
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.035 0.2856 0.7299
Onchocerca volvulus Pyruvate kinase homolog 0.0072 0.048 0.1118
Entamoeba histolytica pyruvate kinase, putative 0.005 0.0293 0.0963
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.038 0.0564
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0022 0.0027
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0031 0.0065
Brugia malayi beta-lactamase family protein 0.0186 0.1448 0.287
Echinococcus granulosus pyruvate kinase 0.0072 0.048 0.0711
Loa Loa (eye worm) hypothetical protein 0.0057 0.035 0.0674
Loa Loa (eye worm) hypothetical protein 0.0021 0.0043 0.0063
Trypanosoma cruzi hypothetical protein, conserved 0.0186 0.1448 0.7847
Echinococcus granulosus pyruvate kinase 0.0037 0.0179 0.0265
Mycobacterium tuberculosis Probable hydrolase 0.0186 0.1448 0.1432
Schistosoma mansoni DNA polymerase eta 0.002 0.0031 0.0046
Schistosoma mansoni transcription factor LCR-F1 0.0049 0.0281 0.0417
Schistosoma mansoni hypothetical protein 0.0049 0.0282 0.0418
Trichomonas vaginalis pyruvate kinase, putative 0.0072 0.048 0.1184
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0057 0.035 0.0519
Loa Loa (eye worm) hypothetical protein 0.0022 0.0049 0.0074
Leishmania major hypothetical protein, conserved 0.0186 0.1448 0.7847
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0049 0.0072
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0104 0.0169
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0019 0.5
Loa Loa (eye worm) hypothetical protein 0.0256 0.2053 0.4063
Echinococcus granulosus histone acetyltransferase MYST2 0.0065 0.0418 0.0619
Echinococcus granulosus caax prenyl protease 1 0.0045 0.0248 0.0367
Mycobacterium tuberculosis Probable reductase 0.0072 0.0476 0.0457
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0058 0.0354 0.0433
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0049 0.0074
Brugia malayi MH1 domain containing protein 0.0027 0.009 0.0171
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0605 0.5037 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0043 0.0063
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.035 0.2856 0.7299
Echinococcus multilocularis Niemann Pick C1 protein 0.0118 0.087 0.1065
Loa Loa (eye worm) matrixin family protein 0.0089 0.0626 0.1223
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0031 0.0065
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0061 0.0383 0.0568
Schistosoma mansoni hypothetical protein 0.0049 0.0281 0.0417
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.031 0.2507 0.4967
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0021
Brugia malayi jmjC domain containing protein 0.0019 0.0022 0.0036
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0049 0.0072
Schistosoma mansoni cpg binding protein 0.0062 0.0388 0.0576
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0049 0.0072
Loa Loa (eye worm) hypothetical protein 0.0022 0.0049 0.0074
Echinococcus granulosus CAAX prenyl protease 2 0.0061 0.0383 0.0568
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0024 0.0066 0.008
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0022 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0049 0.0089
Echinococcus multilocularis zinc finger protein 0.0023 0.0055 0.0067
Loa Loa (eye worm) pyruvate kinase 0.0072 0.048 0.0932
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0049 0.0089
Trichomonas vaginalis glucosylceramidase, putative 0.031 0.2507 0.6402
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0031 0.0023
Entamoeba histolytica hypothetical protein 0.0049 0.0281 0.0923
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0031 0.0046
Echinococcus multilocularis adam 17 protease 0.0122 0.0904 0.1107
Entamoeba histolytica hypothetical protein 0.0049 0.0281 0.0923
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0049 0.0074
Plasmodium vivax hypothetical protein, conserved 0.0186 0.1448 0.7847
Brugia malayi Pre-SET motif family protein 0.0416 0.3416 0.678
Onchocerca volvulus Matrilysin homolog 0.0089 0.0626 0.1497
Toxoplasma gondii pyruvate kinase PyKII 0.0037 0.0179 0.0875
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0372 0.3042 0.4511
Loa Loa (eye worm) hypothetical protein 0.0022 0.0049 0.0074
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.0713 0.1409
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0031 0.0065
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.0713 0.1396
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0065 0.0418 0.0511
Schistosoma mansoni survival motor neuron protein 0.0032 0.0136 0.0202
Schistosoma mansoni carbonic anhydrase-related 0.0112 0.0823 0.122
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0049 0.0281 0.0262
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0049 0.0074
Schistosoma mansoni hypothetical protein 0.0049 0.0279 0.0413
Trypanosoma cruzi pyruvate kinase 2, putative 0.0072 0.048 0.2528
Loa Loa (eye worm) hypothetical protein 0.0038 0.0187 0.035
Schistosoma mansoni hypothetical protein 0.0057 0.035 0.0519
Brugia malayi beta-lactamase 0.0186 0.1448 0.287
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0171 0.1324 0.1307
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0031 0.0065
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0049 0.0089
Trypanosoma brucei RNA helicase, putative 0.0049 0.0282 0.1442
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.031 0.2507 0.4974
Brugia malayi Bromodomain containing protein 0.0038 0.0187 0.0363
Schistosoma mansoni Smad4 0.0027 0.009 0.0133
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0104 0.0169
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0082 0.0345
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0031 0.0023
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.004 0.0206 0.0306
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0031 0.0054
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.035 0.2856 0.7299
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0396 0.0485
Loa Loa (eye worm) MBCTL1 0.0065 0.0418 0.0808
Trichomonas vaginalis pyruvate kinase, putative 0.0072 0.048 0.1184
Schistosoma mansoni pyruvate kinase 0.0072 0.048 0.0711
Giardia lamblia Pyruvate kinase 0.0072 0.048 0.1623
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.035 0.2856 0.7299
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0049 0.0281 0.0344
Trichomonas vaginalis esterase, putative 0.0186 0.1448 0.3676
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0208 0.1637 0.8886
Loa Loa (eye worm) hypothetical protein 0.0158 0.1208 0.2381
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0112 0.0823 0.1628
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0351 0.052
Loa Loa (eye worm) hypothetical protein 0.004 0.0206 0.0387
Echinococcus multilocularis pyruvate kinase 0.0057 0.0349 0.0428
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0131 0.0194
Schistosoma mansoni smad1 5 8 and 0.0027 0.009 0.0133
Onchocerca volvulus Huntingtin homolog 0.0119 0.0877 0.2149
Schistosoma mansoni ADAM17 peptidase (M12 family) 0.0122 0.0904 0.1341
Schistosoma mansoni patched 1 0.0051 0.0294 0.0436
Mycobacterium ulcerans hypothetical protein 0.0186 0.1448 0.2848
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0031 0.0065
Schistosoma mansoni hypothetical protein 0.0049 0.0279 0.0413
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0605 0.5037 0.5027
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0082 0.0345
Loa Loa (eye worm) jmjC domain-containing protein 0.0076 0.0508 0.0988
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0065 0.0418 0.0619
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.007 0.0464 0.0688
Schistosoma mansoni niemann-pick C1 (NPC1) 0.012 0.0886 0.1313
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0294 0.0563
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0416 0.3416 0.6775
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0028 0.0104 0.0169
Mycobacterium tuberculosis Probable dehydrogenase 0.0072 0.0476 0.0457
Loa Loa (eye worm) pyruvate kinase-PB 0.005 0.0293 0.056
Loa Loa (eye worm) hypothetical protein 0.0046 0.0251 0.0477
Loa Loa (eye worm) hypothetical protein 0.0022 0.0049 0.0074
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0058 0.0354 0.0525
Loa Loa (eye worm) histone methyltransferase 0.002 0.0029 0.0036
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0345 0.0663
Schistosoma mansoni hypothetical protein 0.0351 0.2864 0.4247
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0031 0.003
Trypanosoma brucei trypanothione reductase 0.0032 0.0131 0.061
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0031 0.004
Schistosoma mansoni dihydrofolate reductase 0.0605 0.5037 0.7468
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0186 0.1448 0.1432
Loa Loa (eye worm) hypothetical protein 0.004 0.0207 0.039
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0186 0.1448 0.2859
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0131 0.0252
Loa Loa (eye worm) hypothetical protein 0.0028 0.0104 0.0185
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0049 0.0089
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.038 0.0465
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0049 0.006
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0049 0.0089
Trichomonas vaginalis glucosylceramidase, putative 0.031 0.2507 0.6402
Schistosoma mansoni pyruvate kinase 0.0072 0.048 0.0711
Mycobacterium ulcerans hydrolase 0.0049 0.0281 0.0522
Echinococcus granulosus GPCR family 2 0.0032 0.0131 0.0194
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0058 0.0354 0.0525
Chlamydia trachomatis pyruvate kinase 0.0072 0.048 0.0875
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0019 0.0022 0.0014
Echinococcus multilocularis carbonic anhydrase 0.0112 0.0823 0.1007
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0049 0.0072
Echinococcus granulosus Niemann Pick C1 protein 0.0169 0.1303 0.1932
Brugia malayi Bromodomain containing protein 0.0078 0.0526 0.1038
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0104 0.0169
Echinococcus multilocularis transcription factor btf3 0.0042 0.0219 0.0269
Entamoeba histolytica hypothetical protein 0.0049 0.0281 0.0923
Trypanosoma brucei pyruvate kinase 1, putative 0.0072 0.048 0.2528
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0033 0.0013
Leishmania major DNA polymerase kappa, putative 0.002 0.0031 0.0065
Giardia lamblia Hypothetical protein 0.0061 0.0383 0.1282
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0372 0.3042 0.3724
Echinococcus granulosus pyruvate kinase 0.0037 0.0179 0.0265
Leishmania major trypanothione reductase 0.0032 0.0131 0.061
Mycobacterium ulcerans beta-lactamase 0.0186 0.1448 0.2848
Trypanosoma brucei unspecified product 0.002 0.0031 0.0065
Mycobacterium leprae Probable lipase LipE 0.0186 0.1448 0.2725
Plasmodium vivax pyruvate kinase, putative 0.0072 0.048 0.2528
Loa Loa (eye worm) mbt repeat family protein 0.0057 0.035 0.0674
Brugia malayi steroid hormone receptor 0.0022 0.0049 0.0089
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0219 0.0515
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0049 0.006
Loa Loa (eye worm) hypothetical protein 0.0051 0.0294 0.0563
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0072 0.048 0.0461
Mycobacterium tuberculosis Probable oxidoreductase 0.008 0.0544 0.0526
Trichomonas vaginalis D-aminoacylase, putative 0.0186 0.1448 0.3676
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0972 0.817 1
Trypanosoma brucei CAAX amino terminal protease, putative 0.0061 0.0383 0.1998
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0022 0.0014
Echinococcus multilocularis pyruvate kinase 0.0072 0.048 0.0587
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0171 0.1324 0.26
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0022 0.0027
Entamoeba histolytica CAAX prenyl protease family 0.0061 0.0383 0.1282
Brugia malayi CXXC zinc finger family protein 0.0057 0.0345 0.0677
Schistosoma mansoni carbonic anhydrase-related 0.0112 0.0823 0.122
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0372 0.3042 0.6031
Schistosoma mansoni hypothetical protein 0.0032 0.0131 0.0194
Toxoplasma gondii histone lysine methyltransferase SET1 0.0112 0.0816 0.4373
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0049 0.0072
Mycobacterium ulcerans lipase LipD 0.0186 0.1448 0.2848
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0031 0.0065
Loa Loa (eye worm) hypothetical protein 0.0028 0.0104 0.0185
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0028 0.0104 0.0169
Loa Loa (eye worm) MH2 domain-containing protein 0.0392 0.3215 0.6374
Schistosoma mansoni jumonji domain containing protein 0.007 0.0464 0.0688
Loa Loa (eye worm) peptidase family M48 containing protein 0.0045 0.0248 0.047
Echinococcus granulosus carbonic anhydrase 0.0112 0.0823 0.122
Leishmania major pyruvate kinase 0.0072 0.048 0.2528
Echinococcus multilocularis histone acetyltransferase MYST2 0.0065 0.0418 0.0511
Trichomonas vaginalis Clan MA, family M48, Ste24 endopeptidase-like metallopeptidase 0.0045 0.0248 0.0587
Leishmania major carbonic anhydrase-like protein 0.0208 0.1637 0.8886
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0049 0.0282 0.0539
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0031 0.0065
Onchocerca volvulus 0.0186 0.1448 0.3628
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0131 0.016
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0049 0.0072
Loa Loa (eye worm) hypothetical protein 0.0186 0.1448 0.2859
Loa Loa (eye worm) hypothetical protein 0.0065 0.0418 0.0808
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0208 0.1637 0.3235
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0231 0.184 1
Trichomonas vaginalis glucosylceramidase, putative 0.0203 0.1598 0.406
Plasmodium vivax JmjC domain containing protein 0.0019 0.0022 0.0014
Onchocerca volvulus 0.0186 0.1448 0.3628
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0049 0.006
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0072 0.0476 0.0457
Loa Loa (eye worm) matrix metalloproteinase 0.004 0.0206 0.0387
Loa Loa (eye worm) hypothetical protein 0.0022 0.0049 0.0074
Echinococcus multilocularis protein patched 0.0051 0.0294 0.036
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0028 0.0104 0.0169
Echinococcus multilocularis dnaJ subfamily B 0.0805 0.6744 0.8255
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0112 0.0823 0.1615
Loa Loa (eye worm) hypothetical protein 0.0028 0.0104 0.0185
Toxoplasma gondii hypothetical protein 0.0112 0.0823 0.4414
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0104 0.0299
Loa Loa (eye worm) hypothetical protein 0.0186 0.1448 0.2859
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0049 0.0074
Brugia malayi beta-NAC-like protein 0.0042 0.0219 0.0428
Entamoeba histolytica transcription factor BTF3, putative 0.0042 0.0219 0.0705
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0061 0.0383 0.0568
Schistosoma mansoni hypothetical protein 0.0112 0.0823 0.122
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.008 0.0119
Trichomonas vaginalis glucosylceramidase, putative 0.031 0.2507 0.6402
Trypanosoma brucei carbonic anhydrase-like protein 0.0208 0.1637 0.8886
Brugia malayi Dihydrofolate reductase 0.0605 0.5037 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.0713 0.1409
Echinococcus granulosus expressed conserved protein 0.0111 0.0809 0.1199
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0006 0.0009
Echinococcus granulosus dihydrofolate reductase 0.0605 0.5037 0.7468
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0032 0.0131 0.0111
Loa Loa (eye worm) dihydrofolate reductase 0.0605 0.5037 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0031 0.0065
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0118 0.087 0.2999
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0006 0.0009
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0208 0.1637 0.8886
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0104 0.0465
Brugia malayi PHD-finger family protein 0.0028 0.01 0.0192
Loa Loa (eye worm) hypothetical protein 0.0119 0.0877 0.1723
Echinococcus granulosus microtubule associated protein 2 0.046 0.3792 0.5622
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0031 0.0046
Echinococcus granulosus Niemann Pick C1 protein 0.0118 0.087 0.129
Echinococcus multilocularis thioredoxin glutathione reductase 0.0032 0.0131 0.016
Brugia malayi jmjC domain containing protein 0.0019 0.0022 0.0036
Plasmodium vivax pyruvate kinase 2, putative 0.0037 0.0179 0.0875
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0031 0.0042
Loa Loa (eye worm) beta-lactamase 0.0186 0.1448 0.2859
Echinococcus multilocularis Smad4 0.0027 0.009 0.011
Schistosoma mansoni cpg binding protein 0.0057 0.0345 0.0511
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0231 0.184 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0383 0.074
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0208 0.1637 0.2428
Echinococcus multilocularis mitogen activated protein kinase 3 0.0049 0.0282 0.0345
Brugia malayi ecdysteroid receptor 0.0022 0.0049 0.0089
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0031 0.0054
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.008 0.0544 0.0892
Trichomonas vaginalis glucosylceramidase, putative 0.0203 0.1598 0.406
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0122 0.0905 0.1342
Loa Loa (eye worm) MH2 domain-containing protein 0.0027 0.009 0.0156
Trypanosoma brucei transcription factor BTF3, putative 0.0042 0.0219 0.1099
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0072 0.0476 0.0457
Loa Loa (eye worm) hypothetical protein 0.0186 0.1448 0.2859
Trypanosoma cruzi CAAX prenyl protease 2, putative 0.0061 0.0383 0.1998
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0104 0.0169
Echinococcus granulosus adam 0.0021 0.0043 0.0063
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0043 0.0023
Echinococcus granulosus pyruvate kinase 0.0072 0.048 0.0711
Trichomonas vaginalis glucosylceramidase, putative 0.0203 0.1598 0.406
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0057 0.035 0.0781
Schistosoma mansoni jumonji/arid domain-containing protein 0.0076 0.0508 0.0753
Onchocerca volvulus Matrilysin homolog 0.004 0.0206 0.0408
Loa Loa (eye worm) hypothetical protein 0.004 0.0206 0.0387
Echinococcus granulosus mitogen activated protein kinase 0.0049 0.0282 0.0418
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.035 0.2856 0.7299
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0231 0.184 1
Loa Loa (eye worm) hypothetical protein 0.0186 0.1448 0.2859
Schistosoma mansoni bromodomain containing protein 0.0066 0.0426 0.0632
Leishmania major hypothetical protein, conserved 0.0019 0.0022 0.0014
Brugia malayi jmjC domain containing protein 0.007 0.0464 0.0914
Trichomonas vaginalis glucosylceramidase, putative 0.0203 0.1598 0.406
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0167 0.0247
Loa Loa (eye worm) hypothetical protein 0.007 0.0462 0.0897
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0049 0.0072
Brugia malayi Smad1 0.0027 0.009 0.0171
Onchocerca volvulus 0.0057 0.035 0.0782
Leishmania major basic transcription factor 3a, putative 0.0042 0.0219 0.1099
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0049 0.0089
Trypanosoma brucei hypothetical protein, conserved 0.0186 0.1448 0.7847
Brugia malayi hypothetical protein 0.0021 0.0043 0.0077
Giardia lamblia Kinase, CMGC MAPK 0.0049 0.0282 0.0926
Brugia malayi mbt repeat family protein 0.0057 0.035 0.0688
Echinococcus granulosus histone lysine methyltransferase setb 0.0078 0.0525 0.0779
Schistosoma mansoni hypothetical protein 0.0032 0.0131 0.0194
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0443 0.0873
Treponema pallidum fructose-bisphosphate aldolase 0.035 0.2856 1
Loa Loa (eye worm) hypothetical protein 0.0186 0.1448 0.2859
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0049 0.0089
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0072 0.0476 0.0457
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0031 0.0065
Brugia malayi MH2 domain containing protein 0.0392 0.3215 0.6379
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0022 0.0021
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0049 0.0282 0.1443
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0208 0.1637 0.3245
Brugia malayi hypothetical protein 0.0026 0.0082 0.0156
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0049 0.0089
Echinococcus multilocularis carbonic anhydrase 0.0112 0.0823 0.1007
Schistosoma mansoni jumonji/arid domain-containing protein 0.0076 0.0508 0.0753
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0049 0.0072
Leishmania major CAAX prenyl protease 1, putative,metallo-peptidase, Clan M-, Family M48 0.0045 0.0248 0.1254
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0049 0.006
Loa Loa (eye worm) hypothetical protein 0.0119 0.0877 0.1723
Brugia malayi CHE-14 protein 0.0051 0.0294 0.0577
Trichomonas vaginalis glucosylceramidase, putative 0.0203 0.1598 0.406
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0021 0.0043 0.0063
Brugia malayi Niemann-Pick C1 protein precursor 0.0118 0.087 0.1721
Onchocerca volvulus 0.0061 0.038 0.086
Giardia lamblia Fructose-bisphosphate aldolase 0.035 0.2856 1
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0147 0.1115 0.1653
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0078 0.0525 0.0779
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0029 0.0044
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0605 0.5037 1
Schistosoma mansoni pyruvate kinase 0.0037 0.0179 0.0265
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0037 0.005
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0043 0.0128
Schistosoma mansoni myelin transcription factor 1 myt1 0.0065 0.0418 0.0619
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0219 0.0515
Loa Loa (eye worm) hypothetical protein 0.0186 0.1448 0.2859
Schistosoma mansoni cpg binding protein 0.0062 0.0388 0.0576
Echinococcus multilocularis GPCR, family 2 0.0032 0.0131 0.016
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0077 0.0516 0.0765
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0031 0.0065
Schistosoma mansoni hypothetical protein 0.0021 0.0037 0.0054
Mycobacterium tuberculosis Probable esterase LipL 0.0186 0.1448 0.1432
Schistosoma mansoni hypothetical protein 0.0548 0.4545 0.6739
Trichomonas vaginalis D-aminoacylase, putative 0.0186 0.1448 0.3676
Schistosoma mansoni hypothetical protein 0.0032 0.0131 0.0194
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0104 0.0465
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0049 0.0282 0.1443
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0049 0.0072
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0104 0.0199
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0104 0.0085
Brugia malayi Hemopexin family protein 0.0057 0.035 0.0688
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.035 0.2856 0.7299
Echinococcus granulosus carbonic anhydrase 0.0112 0.0823 0.122
Onchocerca volvulus Pyruvate kinase homolog 0.0072 0.048 0.1118
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0049 0.0074
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0372 0.3042 0.4511
Schistosoma mansoni hypothetical protein 0.0049 0.0279 0.0413
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0104 0.0199
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0282 0.1443
Echinococcus granulosus SAM and MBT domain containing protein 0.0057 0.035 0.0519
Entamoeba histolytica CAAX prenyl protease, putative 0.0045 0.0248 0.0805
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0294 0.0707
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0186 0.1448 0.2147
Brugia malayi jmjC domain containing protein 0.0019 0.0022 0.0036
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0049 0.0072
Entamoeba histolytica hypothetical protein 0.0049 0.0281 0.0923
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0021
Brugia malayi glutathione reductase 0.0032 0.0131 0.0252
Trypanosoma cruzi peptidase with unknown catalytic mechanism (family U48) 0.0061 0.0383 0.1998
Schistosoma mansoni smad1 5 8 and 0.0027 0.009 0.0133
Echinococcus granulosus carbonic anhydrase II 0.0208 0.1637 0.2428
Echinococcus granulosus Smad4 0.0027 0.009 0.0133
Onchocerca volvulus Glucosylceramidase homolog 0.0203 0.1598 0.4015
Loa Loa (eye worm) hypothetical protein 0.005 0.0293 0.056
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0231 0.184 1
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0022 0.0048 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0049 0.0089
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0077 0.0516 0.0631
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0031 0.0012
Schistosoma mansoni hypothetical protein 0.0032 0.0131 0.0194
Trypanosoma brucei pyruvate kinase 1 0.0072 0.048 0.2528
Brugia malayi hypothetical protein 0.0049 0.0281 0.0551
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0186 0.1448 0.287
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0147 0.1115 0.1365
Onchocerca volvulus Matrix metalloproteinase homolog 0.0089 0.0626 0.1497
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0027 0.0095 0.0141
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0031 0.0065
Echinococcus multilocularis survival motor neuron protein 1 0.0158 0.1208 0.1479
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0131 0.0238
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0006 0.0008
Echinococcus multilocularis pyruvate kinase 0.0037 0.0179 0.0219
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0282 0.0676
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0078 0.0525 0.0643
Echinococcus granulosus zinc finger protein 0.0023 0.0055 0.0082
Echinococcus multilocularis geminin 0.0548 0.4545 0.5563
Chlamydia trachomatis dihydrofolate reductase 0.0605 0.5037 1
Trichomonas vaginalis glucosylceramidase, putative 0.0214 0.1691 0.4301
Onchocerca volvulus Huntingtin homolog 0.0119 0.0877 0.2149
Echinococcus multilocularis pyruvate kinase 0.0072 0.048 0.0587
Loa Loa (eye worm) hypothetical protein 0.0021 0.0043 0.0063
Echinococcus granulosus beta LACTamase domain containing family member 0.0186 0.1448 0.2147
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0049 0.0072
Brugia malayi Matrixin family protein 0.004 0.0206 0.0402
Loa Loa (eye worm) Smad1 0.0027 0.009 0.0156
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0031 0.0046
Echinococcus granulosus geminin 0.0548 0.4545 0.6739
Schistosoma mansoni carbonic anhydrase 0.0112 0.0823 0.122
Giardia lamblia DINP protein human, muc B family 0.002 0.0031 0.0042
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.035 0.2856 1
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.0219 0.1099
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0049 0.0089
Toxoplasma gondii pyruvate kinase PyK1 0.0072 0.048 0.2528
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0031 0.003
Trichomonas vaginalis glucosylceramidase, putative 0.0203 0.1598 0.406
Plasmodium falciparum basic transcription factor 3b, putative 0.0042 0.0219 0.1099
Leishmania major DNA polymerase eta, putative 0.002 0.0031 0.0065
Echinococcus multilocularis SAM and MBT domain containing protein 0.0057 0.035 0.0428
Echinococcus granulosus mitogen activated protein kinase 3 0.0049 0.0282 0.0418
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0019 0.0016
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0033 0.0013
Mycobacterium leprae Probable pyruvate kinase PykA 0.0072 0.048 0.0761
Onchocerca volvulus 0.0057 0.035 0.0781
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0082 0.0345
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0049 0.0089
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0282 0.0676
Schistosoma mansoni hypothetical protein 0.0068 0.0443 0.0657
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0049 0.0089
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0022 0.0033
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.007 0.0464 0.0568
Trichomonas vaginalis glucosylceramidase, putative 0.0203 0.1598 0.406
Loa Loa (eye worm) hypothetical protein 0.0062 0.0392 0.0757
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0031 0.0038
Echinococcus granulosus pyruvate kinase 0.0037 0.0179 0.0265
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0022 0.0021
Mycobacterium ulcerans esterase/lipase LipP 0.0186 0.1448 0.2848
Loa Loa (eye worm) pyruvate kinase 0.0072 0.048 0.0932
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0049 0.006
Echinococcus granulosus lysine specific demethylase 5A 0.0076 0.0508 0.0753
Brugia malayi nuclear hormone receptor 0.0022 0.0049 0.0089
Trichomonas vaginalis penicillin-binding protein, putative 0.0186 0.1448 0.3676
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0186 0.1448 0.1432
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0049 0.0074
Plasmodium falciparum carbonic anhydrase 0.0112 0.0823 0.4414
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0031 0.0065
Trichomonas vaginalis glucosylceramidase, putative 0.031 0.2507 0.6402
Brugia malayi CAAX amino terminal protease family protein 0.0061 0.0383 0.0754
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0208 0.1637 0.2428
Brugia malayi MH2 domain containing protein 0.0027 0.009 0.0171
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0167 0.0204
Mycobacterium tuberculosis Probable lipase LipD 0.0186 0.1448 0.1432
Echinococcus granulosus TGF beta signal transducer SmadC 0.0027 0.009 0.0133
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0049 0.0072
Echinococcus multilocularis dihydrofolate reductase 0.0605 0.5037 0.6165
Plasmodium vivax basic transcription factor 3b, putative 0.0042 0.0219 0.1099
Trypanosoma cruzi metallo- peptidase, Clan M- Family M48 0.0045 0.0248 0.1254
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0229 0.1819 0.2697
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0282 0.0676
Brugia malayi nuclear receptor NHR-88 0.0022 0.0049 0.0089
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0006 0.0009
Brugia malayi Pre-SET motif family protein 0.0061 0.038 0.0748
Loa Loa (eye worm) hypothetical protein 0.01 0.0713 0.1396
Trichomonas vaginalis Clan U, family U48, CaaX prenyl peptidase 2-like 0.0061 0.0383 0.0936
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0033 0.0013
Echinococcus granulosus phd:f box containing protein 0.0019 0.0022 0.0033
Plasmodium falciparum pyruvate kinase 2 0.0037 0.0179 0.0875
Plasmodium falciparum glutathione reductase 0.0032 0.0131 0.061
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0078 0.0525 0.0779
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0031 0.0065
Onchocerca volvulus 0.0057 0.0345 0.0767
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0049 0.0072
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.0022 0.0014
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0082 0.0345
Toxoplasma gondii NAC domain-containing protein 0.0042 0.0219 0.1099
Echinococcus multilocularis dna polymerase kappa 0.002 0.0031 0.0038
Schistosoma mansoni transcription factor btf3 0.0042 0.0219 0.0325
Loa Loa (eye worm) pyruvate kinase 0.0072 0.048 0.0932
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0049 0.006
Schistosoma mansoni farnesylated-protein converting enzyme 1 (M48 family) 0.0045 0.0248 0.0367
Loa Loa (eye worm) MH1 domain-containing protein 0.0027 0.009 0.0156
Schistosoma mansoni hypothetical protein 0.0049 0.0279 0.0413
Brugia malayi jmjC domain containing protein 0.0019 0.0022 0.0036
Loa Loa (eye worm) hypothetical protein 0.0022 0.0049 0.0074
Leishmania major CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) 0.0061 0.0383 0.1998
Loa Loa (eye worm) ICD-1 protein 0.0042 0.0219 0.0414
Loa Loa (eye worm) carbonic anhydrase 3 0.0208 0.1637 0.3235
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.008 0.0544 0.0526
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0082 0.0345
Schistosoma mansoni microtubule-associated protein tau 0.046 0.3792 0.5622
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0031 0.0065
Schistosoma mansoni ap endonuclease 0.0019 0.0019 0.0029
Mycobacterium tuberculosis Conserved protein 0.0186 0.1448 0.1432
Trichomonas vaginalis D-aminoacylase, putative 0.0186 0.1448 0.3676
Loa Loa (eye worm) hypothetical protein 0.0078 0.0525 0.1022
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0104 0.0465
Schistosoma mansoni hypothetical protein 0.0805 0.6744 1
Onchocerca volvulus 0.004 0.0206 0.0408
Echinococcus multilocularis pyruvate kinase 0.0037 0.0179 0.0219
Plasmodium falciparum JmjC domain-containing protein, putative 0.0019 0.0022 0.0014
Entamoeba histolytica hypothetical protein 0.0042 0.0219 0.0705
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0049 0.0072
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.008 0.0119
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0049 0.0282 0.1443
Plasmodium falciparum thioredoxin reductase 0.0032 0.0131 0.061
Loa Loa (eye worm) hypothetical protein 0.0026 0.0082 0.0141
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0031 0.0012
Echinococcus multilocularis mitogen activated protein kinase 0.0049 0.0282 0.0345
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0208 0.1637 0.3245
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0282 0.1443
Schistosoma mansoni hypothetical protein 0.0548 0.4545 0.6739
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0049 0.0089
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0031 0.0065
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.035 0.2856 0.7299
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0229 0.1819 0.2227
Trypanosoma brucei protein kinase, putative 0.0049 0.0282 0.1443

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 100 uM Inhibition of GAT1 transport activity ChEMBL. 16246548

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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