Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | IMP (inosine 5'-monophosphate) dehydrogenase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | Aph-1 protein, putative | 0.0092 | 0.0536 | 0.0261 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0928 | 1 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0095 | 0.0563 | 0.0289 |
Toxoplasma gondii | IMP dehydrogenas | 0.0095 | 0.0563 | 0.0289 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0928 | 1 | 1 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0928 | 1 | 1 |
Trypanosoma cruzi | GMP reductase | 0.0095 | 0.0563 | 0.0289 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0089 | 0.05 | 0.0224 |
Mycobacterium tuberculosis | Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. | 0.007 | 0.0282 | 0.023 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0092 | 0.0536 | 0.0261 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0095 | 0.0563 | 0.0563 |
Mycobacterium ulcerans | proteasome PrcB | 0.0928 | 1 | 1 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0928 | 1 | 1 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0089 | 0.05 | 0.0224 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.0237 | 0.2174 | 0.1947 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0928 | 1 | 1 |
Brugia malayi | gamma-secretase subunit aph-1 | 0.0237 | 0.2174 | 0.1947 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0928 | 1 | 1 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0928 | 1 | 1 |
Echinococcus granulosus | proteasome prosome macropain | 0.0928 | 1 | 1 |
Trypanosoma brucei | GMP reductase | 0.0095 | 0.0563 | 0.0289 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0095 | 0.0563 | 0.0289 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0928 | 1 | 1 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0095 | 0.0563 | 0.0512 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0095 | 0.0563 | 0.0563 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0928 | 1 | 1 |
Mycobacterium leprae | probable proteasome (alpha subunit) PrcA | 0.007 | 0.0282 | 0.0282 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0095 | 0.0563 | 0.0289 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0928 | 1 | 1 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase family protein | 0.0095 | 0.0563 | 0.0289 |
Trypanosoma cruzi | GMP reductase | 0.0095 | 0.0563 | 0.0289 |
Onchocerca volvulus | Notchless protein homolog | 0.007 | 0.0282 | 0.5 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.0237 | 0.2174 | 0.1947 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.0237 | 0.2174 | 0.1947 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0928 | 1 | 1 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0095 | 0.0563 | 0.0289 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0095 | 0.0563 | 0.0289 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0928 | 1 | 1 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.0237 | 0.2174 | 0.1947 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0095 | 0.0563 | 1 |
Mycobacterium ulcerans | proteasome PrcA | 0.007 | 0.0282 | 0.0282 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0095 | 0.0563 | 0.0289 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.005 | 0.0054 | 0.0054 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0928 | 1 | 1 |
Trypanosoma brucei | Aph-1 protein, putative | 0.0092 | 0.0536 | 0.0261 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0095 | 0.0563 | 0.0289 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0928 | 1 | 1 |
Leishmania major | guanosine monophosphate reductase | 0.0095 | 0.0563 | 0.0289 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0095 | 0.0563 | 0.0289 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0095 | 0.0563 | 0.0289 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0089 | 0.05 | 0.05 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0928 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.041 uM | Inhibition of inosine-5'-monophosphate dehydrogenase 2. | ChEMBL. | 12781195 |
IC50 (binding) | = 0.041 uM | Inhibition of inosine-5'-monophosphate dehydrogenase 2. | ChEMBL. | 12781195 |
IC50 (functional) | = 3.6 uM | Inhibition of CEM cell proliferation. | ChEMBL. | 12781195 |
IC50 (functional) | = 3.6 uM | Inhibition of CEM cell proliferation. | ChEMBL. | 12781195 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 12781195 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.