Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | retinoid X receptor, alpha | Starlite/ChEMBL | References |
Homo sapiens | retinoic acid receptor, alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | ecdysteroid receptor | retinoid X receptor, alpha | 435 aa | 352 aa | 23.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0129 | 0.4203 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.014 | 0.4643 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0256 | 0.9167 | 0.9589 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.014 | 0.4643 | 1 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0266 | 0.956 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0266 | 0.956 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | nM | Effective concentration for Retinoic acid receptor alpha activity in CV-1 cells; Not determined | ChEMBL. | 15056000 |
EC50 (functional) | nM | Effective concentration for Retinoid X receptor alpha activity in CV-1 cells; Not determined | ChEMBL. | 15056000 |
EC50 (functional) | nM | Effective concentration for lipogenesis induced by retinoid X receptor alpha in C3H10T1/2 clone 8 fibroblast cells; Not determined | ChEMBL. | 15056000 |
EC50 (functional) | 0 nM | Effective concentration for Retinoid X receptor alpha activity in CV-1 cells; Not determined | ChEMBL. | 15056000 |
EC50 (functional) | 0 nM | Effective concentration for lipogenesis induced by retinoid X receptor alpha in C3H10T1/2 clone 8 fibroblast cells; Not determined | ChEMBL. | 15056000 |
EC50 (functional) | 0 nM | Effective concentration for Retinoic acid receptor alpha activity in CV-1 cells; Not determined | ChEMBL. | 15056000 |
EC50 (functional) | = 57 nM | Effective concentration for retinoic acid receptor alpha induced lipogenesis in C3H10T1/2 clone 8 fibroblast cells | ChEMBL. | 15056000 |
EC50 (functional) | = 57 nM | Effective concentration for retinoic acid receptor alpha induced lipogenesis in C3H10T1/2 clone 8 fibroblast cells | ChEMBL. | 15056000 |
Ki (binding) | = 138 nM | Binding affinity for retinoid X receptor alpha (RXRalpha), using 9-cis-[3H]-retinoic acid | ChEMBL. | 15056000 |
Ki (binding) | = 138 nM | Binding affinity for retinoid X receptor alpha (RXRalpha), using 9-cis-[3H]-retinoic acid | ChEMBL. | 15056000 |
Ki (binding) | > 1000 nM | Binding affinity for retinoic acid receptor alpha (RARalpha), using 9-cis-[3H]-retinoic acid | ChEMBL. | 15056000 |
Ki (binding) | > 1000 nM | Binding affinity for retinoic acid receptor alpha (RARalpha), using 9-cis-[3H]-retinoic acid | ChEMBL. | 15056000 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.