Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Anandamide amidohydrolase | Starlite/ChEMBL | References |
Rattus norvegicus | Monoglyceride lipase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.1308 | 0.1174 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.1895 | 0.3681 |
Mycobacterium ulcerans | lysophospholipase | 0.0084 | 0.515 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.1308 | 0.1174 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0123 | 0.7717 | 0.7708 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.515 | 1 |
Leishmania major | monoglyceride lipase, putative | 0.0084 | 0.515 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0136 | 0.855 | 1 |
Echinococcus multilocularis | glutamyl tRNA(Gln) amidotransferase subunit A | 0.0015 | 0.0565 | 0.0527 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.2508 | 0.2901 |
Mycobacterium tuberculosis | Possible lysophospholipase | 0.0084 | 0.515 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0059 | 0.3479 | 0.4041 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0035 | 0.1895 | 0.1863 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0158 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.7717 | 0.7682 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.1895 | 0.3083 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0015 | 0.0565 | 0.0617 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0158 | 1 | 1 |
Brugia malayi | Amidase family protein | 0.0015 | 0.0565 | 0.0426 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0123 | 0.7717 | 0.7708 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0384 | 0.0236 |
Trypanosoma brucei | glucosidase, putative | 0.0035 | 0.1895 | 0.3083 |
Schistosoma mansoni | intermediate filament proteins | 0.0026 | 0.1308 | 0.149 |
Trypanosoma cruzi | amidase, putative | 0.0015 | 0.0565 | 0.0255 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0015 | 0.0565 | 0.0527 |
Brugia malayi | putative amidase | 0.0015 | 0.0565 | 0.0426 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.1308 | 0.1174 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.1308 | 0.1273 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0158 | 1 | 1 |
Schistosoma mansoni | alpha glucosidase | 0.0035 | 0.1895 | 0.218 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0028 | 0.142 | 0.1288 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.2508 | 0.2478 |
Plasmodium falciparum | lysophospholipase, putative | 0.0084 | 0.515 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.1525 | 0.1745 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.515 | 1 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0013 | 0.0416 | 0.0377 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.1277 | 0.1142 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.2508 | 0.2393 |
Trypanosoma cruzi | monoglyceride lipase, putative | 0.0084 | 0.515 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.1308 | 0.1273 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0123 | 0.7717 | 0.9022 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.2508 | 0.2901 |
Trypanosoma cruzi | amidase, putative | 0.0015 | 0.0565 | 0.0255 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0158 | 1 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0029 | 0.1525 | 0.1491 |
Echinococcus granulosus | cpg binding protein | 0.0029 | 0.1525 | 0.1491 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0416 | 0.0268 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0035 | 0.1895 | 0.3681 |
Onchocerca volvulus | 0.0026 | 0.1308 | 0.1672 | |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.1895 | 0.3681 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.2508 | 0.2478 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0084 | 0.515 | 1 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0084 | 0.515 | 1 |
Echinococcus granulosus | glutamyl tRNAGln amidotransferase subunit A | 0.0015 | 0.0565 | 0.0527 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0084 | 0.515 | 1 |
Schistosoma mansoni | amidase | 0.0123 | 0.7717 | 0.9022 |
Echinococcus multilocularis | lamin | 0.0026 | 0.1308 | 0.1273 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0013 | 0.0445 | 0.0864 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0013 | 0.0445 | 0.0864 |
Brugia malayi | Amidase family protein | 0.0015 | 0.0565 | 0.0426 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.515 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0035 | 0.1895 | 0.3083 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0035 | 0.1895 | 0.3083 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0014 | 0.0508 | 0.0368 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0123 | 0.7717 | 0.7708 |
Brugia malayi | CXXC zinc finger family protein | 0.0028 | 0.142 | 0.1294 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.1308 | 0.118 |
Brugia malayi | amidase | 0.0123 | 0.7717 | 0.7684 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0015 | 0.0565 | 0.0527 |
Schistosoma mansoni | alpha-glucosidase | 0.0136 | 0.855 | 1 |
Onchocerca volvulus | 0.0091 | 0.5608 | 1 | |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.1895 | 0.3681 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0013 | 0.0445 | 0.0864 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0013 | 0.0445 | 0.0304 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.515 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0013 | 0.0445 | 0.0864 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.2508 | 0.2478 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.142 | 0.1622 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0035 | 0.1895 | 0.3083 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0053 | 0.3063 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0084 | 0.515 | 1 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.1308 | 0.118 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0013 | 0.0416 | 0.0377 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.2508 | 0.2478 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0152 | 0.0112 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0035 | 0.1895 | 0.3681 |
Mycobacterium leprae | POSSIBLE LYSOPHOSPHOLIPASE | 0.0084 | 0.515 | 1 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0013 | 0.0445 | 0.0864 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0384 | 0.0236 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.1895 | 0.3083 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0084 | 0.515 | 1 |
Plasmodium falciparum | lysophospholipase, putative | 0.0084 | 0.515 | 1 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0013 | 0.0445 | 0.0864 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0035 | 0.1895 | 0.177 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0035 | 0.1895 | 0.1776 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0035 | 0.1895 | 0.1863 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.1308 | 0.1273 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0013 | 0.0445 | 0.0864 |
Plasmodium falciparum | esterase, putative | 0.0084 | 0.515 | 1 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0015 | 0.0565 | 0.5 |
Schistosoma mansoni | lamin | 0.0026 | 0.1308 | 0.149 |
Trypanosoma brucei | fatty-acid amide hydrolase, putative | 0.0015 | 0.0565 | 0.0255 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.1525 | 0.1745 |
Trichomonas vaginalis | valacyclovir hydrolase, putative | 0.0084 | 0.515 | 1 |
Onchocerca volvulus | 0.0026 | 0.1308 | 0.1672 | |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0015 | 0.0565 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0084 | 0.515 | 1 |
Onchocerca volvulus | 0.0028 | 0.142 | 0.1889 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.2508 | 0.2901 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0035 | 0.1895 | 0.3681 |
Plasmodium vivax | PST-A protein | 0.0084 | 0.515 | 1 |
Plasmodium falciparum | lysophospholipase, putative | 0.0084 | 0.515 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0152 | 0.0112 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.1895 | 0.3681 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.2508 | 0.2398 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.515 | 1 |
Echinococcus multilocularis | musashi | 0.0026 | 0.1308 | 0.1273 |
Mycobacterium ulcerans | hypothetical protein | 0.0084 | 0.515 | 1 |
Echinococcus granulosus | lamin | 0.0026 | 0.1308 | 0.1273 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0035 | 0.1895 | 0.3681 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.1895 | 0.3681 |
Leishmania major | hypothetical protein, conserved | 0.0015 | 0.0565 | 0.0255 |
Loa Loa (eye worm) | amidase | 0.0015 | 0.0565 | 0.0419 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0445 | 0.0297 |
Loa Loa (eye worm) | amidase | 0.0015 | 0.0565 | 0.0419 |
Schistosoma mansoni | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0015 | 0.0565 | 0.0617 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0013 | 0.0445 | 0.0864 |
Schistosoma mansoni | lamin | 0.0026 | 0.1308 | 0.149 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0015 | 0.0565 | 0.5 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0508 | 0.0361 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0123 | 0.7717 | 0.7708 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.