Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nitric oxide synthase 3 (endothelial cell) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | sulfite reductase, putative | 0.0032 | 0.5237 | 1 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0016 | 0.0878 | 0.0878 |
Brugia malayi | FAD binding domain containing protein | 0.002 | 0.1927 | 0.0501 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0032 | 0.5237 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.4201 | 0.6511 |
Echinococcus multilocularis | methionine synthase reductase | 0.002 | 0.1927 | 0.1927 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0032 | 0.5237 | 1 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0029 | 0.4253 | 0.6688 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0032 | 0.5237 | 0.5237 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.2267 | 0.0901 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.2267 | 0.2267 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.2267 | 0.2267 |
Leishmania major | p450 reductase, putative | 0.0032 | 0.5237 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0021 | 0.2267 | 0.4181 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0032 | 0.5237 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.2267 | 0.0421 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.4201 | 0.6511 |
Trypanosoma cruzi | p450 reductase, putative | 0.0032 | 0.5237 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0032 | 0.5237 | 0.5237 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0029 | 0.4253 | 0.6688 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0.4201 | 0.6511 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0.2267 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 1 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.2267 | 0.2267 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.4201 | 0.6511 |
Chlamydia trachomatis | sulfite reductase | 0.002 | 0.1927 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 1 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.2267 | 0.2267 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.4201 | 0.2816 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0032 | 0.5237 | 0.5237 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0032 | 0.5237 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.4201 | 0.6511 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.002 | 0.1927 | 0.1927 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.4201 | 0.6511 |
Giardia lamblia | Hypothetical protein | 0.0029 | 0.4253 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0032 | 0.5237 | 0.41 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0032 | 0.5237 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0032 | 0.5237 | 0.5237 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0032 | 0.5237 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 1 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0032 | 0.5237 | 1 |
Brugia malayi | hypothetical protein | 0.0028 | 0.4201 | 0.3177 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.4201 | 0.6511 |
Leishmania major | cytochrome P450 reductase, putative | 0.0029 | 0.4253 | 0.6688 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0032 | 0.5237 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0032 | 0.5237 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5237 | 0.41 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0016 | 0.0943 | 0.0943 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0032 | 0.5237 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0032 | 0.5237 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0032 | 0.5237 | 0.5237 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0021 | 0.2267 | 0.5 |
Brugia malayi | flavodoxin family protein | 0.0032 | 0.5237 | 0.4396 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0028 | 0.4201 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0021 | 0.2267 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0032 | 0.5237 | 0.4396 |
Echinococcus granulosus | methionine synthase reductase | 0.002 | 0.1927 | 0.1927 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0.2267 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0029 | 0.4253 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 8 uM | Inhibitory activity against human endothelial nitric oxide synthase (eNOS) isoenzyme. | ChEMBL. | 9667974 |
Ki (binding) | = 29 uM | Inhibitory activity against human neuronal nitric oxide synthase (nNOS) isoenzyme. | ChEMBL. | 9667974 |
Ki (binding) | = 46 uM | Inhibitory activity against human inducible nitric oxide synthase (iNOS) isoenzyme. | ChEMBL. | 9667974 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.