Detailed information for compound 1033768

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 294.744 | Formula: C13H18ClF3N2
  • H donors: 1 H acceptors: 0 LogP: 3.67 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN/C(=N\CC)/Cc1cccc(c1)C(F)(F)F.Cl
  • InChi: 1S/C13H17F3N2.ClH/c1-3-17-12(18-4-2)9-10-6-5-7-11(8-10)13(14,15)16;/h5-8H,3-4,9H2,1-2H3,(H,17,18);1H
  • InChiKey: ANXYVZRMSHOQNP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0047 0.0046
Giardia lamblia Cathepsin L precursor 0.0132 0.0839 0.5
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0047 0.0094
Brugia malayi Cathepsin L-like precursor 0.0717 0.4988 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0132 0.0839 0.1626
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0064 0.0126
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0132 0.0839 0.1648
Entamoeba histolytica cysteine protease, putative 0.037 0.2521 0.4875
Echinococcus granulosus ferritin 0.0026 0.0081 0.008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0717 0.4988 1
Schistosoma mansoni cathepsin S (C01 family) 0.0132 0.0839 0.1626
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0168
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0132 0.0839 0.1544
Onchocerca volvulus 0.0026 0.0087 0.0081
Onchocerca volvulus Cathepsin F homolog 0.0717 0.4988 1
Plasmodium falciparum serine repeat antigen 2 0.0132 0.0839 0.1648
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0132 0.0839 0.1544
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.087 0.6073 0.6073
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0047 0.0089
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0047 0.0089
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0087 0.0174
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0717 0.4988 1
Leishmania major cathepsin L-like protease 0.0717 0.4988 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0717 0.4988 0.4988
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0132 0.0839 0.1626
Giardia lamblia Cathepsin L precursor 0.0132 0.0839 0.5
Onchocerca volvulus 0.0717 0.4988 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.002 0.004
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0132 0.0839 0.1382
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0047 0.0046
Giardia lamblia Cysteine protease 0.0132 0.0839 0.5
Brugia malayi MH2 domain containing protein 0.0123 0.0769 0.1541
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.048 0.3306 0.6627
Leishmania major cathepsin L-like protease 0.0717 0.4988 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0047 0.0046
Trypanosoma cruzi cysteine proteinase, putative 0.037 0.2521 0.5053
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0717 0.4988 1
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0047 0.0089
Plasmodium falciparum serine repeat antigen 8 0.0132 0.0839 0.1648
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0132 0.0839 0.1648
Entamoeba histolytica cysteine protease, putative 0.0717 0.4988 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.002 0.0019
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0026 0.0081 1
Entamoeba histolytica cysteine proteinase, putative 0.037 0.2521 0.4875
Toxoplasma gondii cathepsin CPL 0.0717 0.4988 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.0839 0.1681
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0047 0.0094
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0047 0.0094
Schistosoma mansoni hypothetical protein 0.0166 0.1077 0.2088
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0132 0.0839 0.1679
Onchocerca volvulus 0.0717 0.4988 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0132 0.0839 0.5
Schistosoma mansoni ferritin 0.0026 0.0081 0.0155
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0047 0.0094
Brugia malayi cathepsin L-like cysteine proteinase 0.0132 0.0839 0.1681
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0237 0.1582 0.3171
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0717 0.4988 1
Brugia malayi Cytochrome P450 family protein 0.0014 0.0001 0.0002
Treponema pallidum bacterioferrin (TpF1) 0.0026 0.0081 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.037 0.2521 0.4972
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0165 0.1066 0.1065
Echinococcus multilocularis cysteine protease 0.0717 0.4988 0.4988
Brugia malayi Cytochrome P450 family protein 0.0023 0.0064 0.0128
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0047 0.0094
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0132 0.0839 0.1626
Schistosoma mansoni ferritin 0.0026 0.0081 0.0155
Entamoeba histolytica cysteine protease, putative 0.0132 0.0839 0.1382
Trypanosoma cruzi cysteine peptidase, putative 0.0237 0.1582 0.317
Entamoeba histolytica cysteine protease, putative 0.037 0.2521 0.4875
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0047 0.0094
Leishmania major cysteine peptidase A (CPA) 0.0717 0.4988 1
Schistosoma mansoni alkaline phosphatase 0.0165 0.1066 0.2067
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0717 0.4988 1
Giardia lamblia Cathepsin L precursor 0.0132 0.0839 0.5
Onchocerca volvulus 0.0026 0.0087 0.0081
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.037 0.2521 0.5053
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.002 0.2343
Mycobacterium ulcerans bacterioferritin BfrA 0.0026 0.0081 1
Loa Loa (eye worm) hypothetical protein 0.0237 0.1582 0.3171
Brugia malayi cathepsin F-like cysteine proteinase 0.0132 0.0839 0.1681
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0717 0.4988 1
Trypanosoma cruzi cysteine protease, putative 0.037 0.2521 0.5053
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0132 0.0839 0.1681
Brugia malayi Latrophilin receptor protein 2 0.0065 0.0357 0.0716
Schistosoma mansoni apoferritin-2 0.0026 0.0081 0.0155
Trypanosoma cruzi cysteine peptidase, putative 0.0717 0.4988 1
Schistosoma mansoni microtubule-associated protein tau 0.0741 0.5153 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0047 0.0089
Brugia malayi isocitrate dehydrogenase 0.0017 0.002 0.004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0717 0.4988 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.002 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0047 0.0094
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0132 0.0839 0.1626
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0717 0.4988 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0717 0.4988 1
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0165 0.1066 0.1065
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0047 0.0089
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0132 0.0839 0.1382
Leishmania major cathepsin L-like protease 0.0717 0.4988 1
Schistosoma mansoni ferritin 0.0026 0.0081 0.0155
Brugia malayi Papain family cysteine protease containing protein 0.037 0.2521 0.5054
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.002 0.0038
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0064 0.0128
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.0357 0.0716
Giardia lamblia Cathepsin L precursor 0.0132 0.0839 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0717 0.4988 1
Entamoeba histolytica cysteine protease, putative 0.0132 0.0839 0.1382
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0047 0.0046
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.0357 0.0716
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0132 0.0839 0.5
Plasmodium vivax vivapain-3 0.037 0.2521 0.5034
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0717 0.4988 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0174 0.0172
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0717 0.4988 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0132 0.0839 0.1544
Schistosoma mansoni cathepsin C 0.0132 0.0839 0.1626
Brugia malayi Cathepsin L-like precursor 0.0717 0.4988 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0217 0.0216
Trypanosoma cruzi cruzipain precursor, putative 0.0237 0.1582 0.317
Schistosoma mansoni hypothetical protein 0.0065 0.0357 0.0691
Schistosoma mansoni ferritin light chain 0.0026 0.0081 0.0155
Entamoeba histolytica cysteine proteinase, putative 0.0717 0.4988 1
Toxoplasma gondii cathepsin CPC2 0.0132 0.0839 0.1679
Leishmania major cathepsin L-like protease 0.0717 0.4988 1
Echinococcus multilocularis lamin 0.0026 0.0087 0.0086
Entamoeba histolytica cysteine protease, putative 0.037 0.2521 0.4875
Brugia malayi Calcitonin receptor-like protein seb-1 0.0204 0.1346 0.2698
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0132 0.0839 0.1648
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.0094
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.0094
Giardia lamblia Cathepsin B precursor 0.0132 0.0839 0.5
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0047 0.0094
Brugia malayi Cathepsin L-like precursor 0.048 0.3306 0.6628
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0717 0.4988 1
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0047 0.0089
Schistosoma mansoni hypothetical protein 0.0166 0.1077 0.2088
Schistosoma mansoni cathepsin F (C01 family) 0.048 0.3306 0.6415
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0047 0.0094
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.002 0.0038
Loa Loa (eye worm) ctsf protein 0.0717 0.4988 1
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0132 0.0839 0.5
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0087 0.0174
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0165 0.1066 0.1065
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.0094
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0165 0.1066 0.1065
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0132 0.0839 0.1648
Brugia malayi fibroinase precursor 0.0132 0.0839 0.1681
Echinococcus granulosus cathepsin b 0.0132 0.0839 0.0838
Plasmodium vivax unspecified product 0.0132 0.0839 0.1648
Giardia lamblia Cathepsin B precursor 0.0132 0.0839 0.5
Trypanosoma cruzi cruzipain precursor, putative 0.0717 0.4988 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0087 0.0174
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0064 0.0126
Schistosoma mansoni cathepsin B (C01 family) 0.0132 0.0839 0.1626
Giardia lamblia Cathepsin B precursor 0.0132 0.0839 0.5
Giardia lamblia Cathepsin L-like protease 0.0132 0.0839 0.5
Echinococcus granulosus cathepsin L cysteine protease 0.037 0.2521 0.252
Echinococcus multilocularis neuropeptide receptor A26 0.1424 1 1
Echinococcus multilocularis cathepsin b 0.0132 0.0839 0.0838
Toxoplasma gondii cathepsin B 0.0132 0.0839 0.1679
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0047 0.0094
Giardia lamblia Cysteine protease 0.0132 0.0839 0.5
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.002 0.0038
Entamoeba histolytica cysteine proteinase 1, putative 0.037 0.2521 0.4875
Brugia malayi cathepsin L precursor 0.0132 0.0839 0.1681
Entamoeba histolytica cysteine protease, putative 0.037 0.2521 0.4875
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0047 0.0094
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.048 0.3306 0.6572
Plasmodium falciparum serine repeat antigen 9 0.0132 0.0839 0.1648
Schistosoma mansoni hypothetical protein 0.0139 0.0888 0.1722
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0132 0.0839 0.1648
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.0357 0.0356
Loa Loa (eye worm) hypothetical protein 0.0132 0.0839 0.1681
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0132 0.0839 0.1544
Loa Loa (eye worm) hypothetical protein 0.0132 0.0839 0.1681
Echinococcus multilocularis cathepsin L cysteine protease 0.0717 0.4988 0.4988
Brugia malayi ecdysteroid receptor 0.0021 0.0047 0.0094
Brugia malayi nuclear hormone receptor 0.0021 0.0047 0.0094
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0047 0.0089
Schistosoma mansoni lamin 0.0026 0.0087 0.0167
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0132 0.0839 0.1648
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0717 0.4988 1
Entamoeba histolytica cysteine protease, putative 0.037 0.2521 0.4875
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.0094
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0047 0.0046
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.037 0.2521 0.4891
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.048 0.3306 0.6628
Loa Loa (eye worm) hypothetical protein 0.0237 0.1582 0.3171
Brugia malayi nuclear receptor NHR-88 0.0021 0.0047 0.0094
Trypanosoma cruzi cysteine proteinase, putative 0.037 0.2521 0.5053
Giardia lamblia Hypothetical protein 0.0132 0.0839 0.5
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0047 0.0046
Toxoplasma gondii cathepsin CPC1 0.0132 0.0839 0.1679
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0047 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0047 0.0094
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0132 0.0839 0.1648
Onchocerca volvulus Cathepsin L homolog 0.0717 0.4988 1
Brugia malayi cathepsin L-like precursor 0.048 0.3306 0.6628
Plasmodium falciparum cysteine proteinase falcipain 3 0.0717 0.4988 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0717 0.4988 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0132 0.0839 0.1681
Trichomonas vaginalis conserved hypothetical protein 0.0132 0.0839 0.1544
Echinococcus multilocularis microtubule associated protein 2 0.0741 0.5153 0.5153
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0717 0.4988 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.0839 0.1681
Plasmodium vivax unspecified product 0.037 0.2521 0.5034
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0132 0.0839 0.1544
Echinococcus granulosus cathepsin b 0.0132 0.0839 0.0838
Schistosoma mansoni lamin 0.0026 0.0087 0.0167
Plasmodium falciparum serine repeat antigen 1 0.0132 0.0839 0.1648
Brugia malayi Cathepsin L-like precursor 0.0717 0.4988 1
Loa Loa (eye worm) fibroinase 0.0717 0.4988 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0047 0.0094
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0717 0.4988 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0237 0.1582 0.3171
Entamoeba histolytica cysteine protease, putative 0.0132 0.0839 0.1382
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0717 0.4988 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.002 0.0019
Schistosoma mansoni ferritin 0.0026 0.0081 0.0155
Echinococcus granulosus cathepsin l1 0.0717 0.4988 0.4988
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.002 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0132 0.0839 0.1544
Schistosoma mansoni cathepsin s 0.0237 0.1582 0.3068
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0047 0.0046
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.002 0.0038
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.0769 0.1541
Echinococcus granulosus neuropeptide receptor A26 0.1424 1 1
Echinococcus multilocularis geminin 0.0166 0.1077 0.1076
Entamoeba histolytica cysteine proteinase, putative 0.037 0.2521 0.4875
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.002 0.0036
Onchocerca volvulus 0.0717 0.4988 1
Echinococcus granulosus intestinal type alkaline phosphatase 0.0165 0.1066 0.1065
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0204 0.1346 0.2698
Mycobacterium ulcerans bacterioferritin BfrB 0.0026 0.0081 1
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.002 0.0038
Brugia malayi steroid hormone receptor 0.0021 0.0047 0.0094
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0717 0.4988 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0047 0.0094
Echinococcus granulosus lamin dm0 0.0026 0.0087 0.0086
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0165 0.1066 0.1065
Echinococcus granulosus intermediate filament protein 0.0026 0.0087 0.0086
Brugia malayi Papain family cysteine protease containing protein 0.0132 0.0839 0.1681
Brugia malayi Cathepsin L-like precursor 0.0237 0.1582 0.3171
Echinococcus multilocularis alkaline phosphatase 0.0165 0.1066 0.1065
Brugia malayi latrophilin 2 splice variant baaae 0.0139 0.0888 0.1781
Entamoeba histolytica cysteine protease, putative 0.037 0.2521 0.4875
Echinococcus granulosus cysteine protease 0.037 0.2521 0.252
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.0357 0.0356
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0132 0.0839 0.1648
Entamoeba histolytica cysteine proteinase, putative 0.0717 0.4988 1
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0132 0.0839 0.1648
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0717 0.4988 0.4988
Echinococcus granulosus cathepsin l cysteine peptidase 0.0717 0.4988 0.4988
Echinococcus multilocularis cathepsin L cysteine protease 0.0717 0.4988 0.4988
Entamoeba histolytica cysteine protease, putative 0.037 0.2521 0.4875
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0132 0.0839 0.1626
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0132 0.0839 0.1626
Schistosoma mansoni hypothetical protein 0.0065 0.0357 0.0691
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.0357 0.0356
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0717 0.4988 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0132 0.0839 0.1681
Brugia malayi Cathepsin L-like precursor 0.048 0.3306 0.6628
Giardia lamblia Cathepsin L precursor 0.0132 0.0839 0.5
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0047 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0717 0.4988 1
Entamoeba histolytica cysteine protease, putative 0.037 0.2521 0.4875
Brugia malayi Cathepsin L-like precursor 0.0717 0.4988 1
Brugia malayi Papain family cysteine protease containing protein 0.037 0.2521 0.5054
Giardia lamblia Cathepsin B precursor 0.0132 0.0839 0.5
Plasmodium vivax serine-repeat antigen (SERA) 0.0132 0.0839 0.1648
Brugia malayi Papain family cysteine protease containing protein 0.0132 0.0839 0.1681
Echinococcus granulosus alkaline phosphatase 0.0165 0.1066 0.1065
Echinococcus granulosus cathepsin L 0.0132 0.0839 0.0838
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0047 0.0046
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0047 0.0046
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0132 0.0839 0.1648
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.0094
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0047 0.0094
Echinococcus multilocularis cathepsin L 0.0132 0.0839 0.0838
Plasmodium falciparum cysteine proteinase falcipain 1 0.037 0.2521 0.5034
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.037 0.2521 0.5053
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.0769 0.1541
Onchocerca volvulus Cathepsin L homolog 0.0717 0.4988 1
Schistosoma mansoni hypothetical protein 0.0065 0.0357 0.0691
Schistosoma mansoni cathepsin F (C01 family) 0.0717 0.4988 0.968
Loa Loa (eye worm) cysteine protease 0.0717 0.4988 1
Plasmodium vivax vivapain-2 0.0717 0.4988 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0132 0.0839 0.1679
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0064 0.0128
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0132 0.0839 0.1626
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0132 0.0839 0.1544
Schistosoma mansoni intermediate filament proteins 0.0026 0.0087 0.0167
Loa Loa (eye worm) cathepsin B 0.0132 0.0839 0.1681
Leishmania major cathepsin L-like protease 0.0717 0.4988 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0717 0.4988 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0132 0.0839 0.1544
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0174 0.0335
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0026 0.0081 1
Echinococcus multilocularis cysteine protease 0.0717 0.4988 0.4988
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0717 0.4988 1
Plasmodium vivax vivapain-2 0.0717 0.4988 1
Echinococcus granulosus geminin 0.0166 0.1077 0.1076
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0047 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0717 0.4988 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.0094
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0717 0.4988 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0132 0.0839 0.1681
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0047 0.0094
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0047 0.0046
Entamoeba histolytica cysteine proteinase, putative 0.037 0.2521 0.4875
Echinococcus granulosus cathepsin L cysteine proteinase 0.0717 0.4988 0.4988
Brugia malayi hypothetical protein 0.0039 0.0174 0.0348
Schistosoma mansoni coup transcription factor 0.0021 0.0047 0.0089
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0132 0.0839 0.1626
Giardia lamblia Cathepsin B precursor 0.0132 0.0839 0.5
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0047 0.0046
Loa Loa (eye worm) hypothetical protein 0.048 0.3306 0.6628
Plasmodium falciparum serine repeat antigen 5 0.0132 0.0839 0.1648
Entamoeba histolytica cysteine proteinase, putative 0.048 0.3306 0.6506
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0132 0.0839 0.1544
Entamoeba histolytica cysteine protease, putative 0.037 0.2521 0.4875
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0132 0.0839 0.1544
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0026 0.0081 0.5
Loa Loa (eye worm) hypothetical protein 0.048 0.3306 0.6628
Entamoeba histolytica cysteine protease, putative 0.037 0.2521 0.4875
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0217 0.0436
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0717 0.4988 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0132 0.0839 0.1679
Echinococcus multilocularis expressed protein 0.0026 0.0081 0.008
Trypanosoma cruzi cysteine peptidase, putative 0.0717 0.4988 1
Giardia lamblia Cathepsin B precursor 0.0132 0.0839 0.5
Loa Loa (eye worm) hypothetical protein 0.0139 0.0888 0.1781
Brugia malayi Isocitrate dehydrogenase 0.0017 0.002 0.004
Echinococcus multilocularis cathepsin L 0.037 0.2521 0.252
Entamoeba histolytica hypothetical protein 0.0132 0.0839 0.1382
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0717 0.4988 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0064 0.7867
Echinococcus multilocularis lamin dm0 0.0026 0.0087 0.0086
Onchocerca volvulus 0.0717 0.4988 1
Onchocerca volvulus 0.0717 0.4988 1
Entamoeba histolytica cysteine protease, putative 0.0132 0.0839 0.1382
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.002 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0132 0.0839 0.1544
Echinococcus multilocularis neuropeptide s receptor 0.1424 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0717 0.4988 1
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0047 0.0046
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0047 0.0046
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0087 0.0174
Schistosoma mansoni apoferritin-2 0.0026 0.0081 0.0155
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0047 0.0094
Brugia malayi intermediate filament protein 0.0026 0.0087 0.0174
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0047 0.0094
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0132 0.0839 0.1648
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0047 0.0046
Plasmodium vivax serine-repeat antigen (SERA) 0.0132 0.0839 0.1648
Leishmania major cathepsin L-like protease 0.0717 0.4988 1
Plasmodium falciparum serine repeat antigen 6 0.0132 0.0839 0.1648
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0717 0.4988 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.0094
Onchocerca volvulus 0.0132 0.0839 0.1603
Schistosoma mansoni cathepsin F (C01 family) 0.0717 0.4988 0.968
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0047 0.0089
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.037 0.2521 0.4891
Echinococcus granulosus cathepsin l1 0.048 0.3306 0.3305
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0047 0.0094
Trypanosoma cruzi cysteine peptidase, putative 0.0717 0.4988 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.0094
Entamoeba histolytica cysteine protease, putative 0.037 0.2521 0.4875
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0132 0.0839 0.1681
Plasmodium falciparum serine repeat antigen 4 0.0132 0.0839 0.1648
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0132 0.0839 0.5
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0064 0.0126
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0132 0.0839 0.1626
Brugia malayi Cytochrome P450 family protein 0.0023 0.0064 0.0128
Trypanosoma cruzi cysteine peptidase, putative 0.037 0.2521 0.5053
Giardia lamblia Cathepsin B precursor 0.0132 0.0839 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0132 0.0839 0.1544
Schistosoma mansoni hypothetical protein 0.0085 0.0506 0.098
Brugia malayi Cathepsin L-like precursor 0.0717 0.4988 1
Echinococcus granulosus lamin 0.0026 0.0087 0.0086
Loa Loa (eye worm) cytochrome P450 0.0014 0.0001 0.0002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0217 0.042
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0132 0.0839 0.1544
Echinococcus multilocularis GPCR, family 2 0.0065 0.0357 0.0356
Echinococcus granulosus expressed protein 0.0026 0.0081 0.008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0717 0.4988 1
Echinococcus multilocularis cathepsin b 0.0132 0.0839 0.0838
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0047 0.0094
Entamoeba histolytica cysteine proteinase, putative 0.037 0.2521 0.4875
Giardia lamblia Cathepsin L precursor 0.0132 0.0839 0.5
Echinococcus multilocularis musashi 0.0026 0.0087 0.0086
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0047 0.0089
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.037 0.2521 0.4891
Entamoeba histolytica cysteine protease, putative 0.037 0.2521 0.4875
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.037 0.2521 0.4972
Giardia lamblia Cysteine protease 0.0132 0.0839 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0217 0.0216
Echinococcus multilocularis ferritin 0.0026 0.0081 0.008
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0132 0.0839 0.1544
Toxoplasma gondii preprocathepsin c precursor, putative 0.0132 0.0839 0.1679
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.0357 0.0356
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0047 0.0094
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0217 0.0436
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0132 0.0839 0.1648
Brugia malayi cathepsin B-like cysteine proteinase 0.0132 0.0839 0.1681
Onchocerca volvulus 0.0717 0.4988 1
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0132 0.0839 0.1544
Leishmania major cathepsin L-like protease 0.0717 0.4988 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0132 0.0839 0.1679
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0717 0.4988 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0357 0.0716
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0717 0.4988 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0132 0.0839 0.1544
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0174 0.0172
Brugia malayi Cytochrome P450 family protein 0.0053 0.0275 0.0551
Brugia malayi cytochrome P450 0.0014 0.0001 0.0002
Plasmodium falciparum serine repeat antigen 3 0.0132 0.0839 0.1648
Entamoeba histolytica cysteine proteinase 2 0.037 0.2521 0.4875
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0026 0.0081 1
Onchocerca volvulus 0.048 0.3306 0.6596
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0047 0.0089
Echinococcus granulosus GPCR family 2 0.0065 0.0357 0.0356
Plasmodium vivax vivapain-1 0.037 0.2521 0.5034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0717 0.4988 1
Trichomonas vaginalis conserved hypothetical protein 0.0132 0.0839 0.1544
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.002 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0047 0.0094
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0132 0.0839 0.1626
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0132 0.0839 0.1626
Loa Loa (eye worm) hypothetical protein 0.0237 0.1582 0.3171
Schistosoma mansoni alkaline phosphatase 0.0165 0.1066 0.2067
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0717 0.4988 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0132 0.0839 0.1544
Giardia lamblia Cysteine protease 0.0132 0.0839 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0717 0.4988 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.0839 0.1681
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0217 0.0216
Entamoeba histolytica cysteine protease, putative 0.0132 0.0839 0.1382
Trypanosoma cruzi major cysteine proteinase, putative 0.0132 0.0839 0.1679
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0132 0.0839 0.1626
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0047 0.0094
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0204 0.1346 0.2698
Schistosoma mansoni hypothetical protein 0.0065 0.0357 0.0691
Giardia lamblia Encystation-specific protease 0.0132 0.0839 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0132 0.0839 0.1544
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0717 0.4988 1
Onchocerca volvulus 0.0717 0.4988 1
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0064 0.0128
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0217 0.042
Giardia lamblia Cathepsin B precursor 0.0132 0.0839 0.5
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0132 0.0839 0.1626
Entamoeba histolytica cysteine protease, putative 0.037 0.2521 0.4875
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0217 0.042
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0217 0.0216
Giardia lamblia Cathepsin L-like protease 0.0132 0.0839 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.048 0.3306 0.6572
Plasmodium falciparum serine repeat antigen 7 0.0132 0.0839 0.1648
Brugia malayi Cathepsin L-like precursor 0.0717 0.4988 1
Entamoeba histolytica cysteine protease, putative 0.0132 0.0839 0.1382
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0047 0.0089
Leishmania major cathepsin L-like protease 0.0717 0.4988 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0237 0.1582 0.3171
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0132 0.0839 0.1648
Giardia lamblia Hypothetical protein 0.0132 0.0839 0.5
Brugia malayi Cathepsin L-like cysteine proteinase 0.048 0.3306 0.6628
Schistosoma mansoni hypothetical protein 0.0039 0.0174 0.0335
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0717 0.4988 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0047 0.0046
Brugia malayi Papain family cysteine protease containing protein 0.0717 0.4988 1
Loa Loa (eye worm) hypothetical protein 0.0204 0.1346 0.2698
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0132 0.0839 0.1626
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0132 0.0839 0.1679
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0717 0.4988 1
Leishmania major cytochrome p450-like protein 0.0023 0.0064 0.0126
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.037 0.2521 0.5053
Echinococcus granulosus cathepsin L 0.037 0.2521 0.252
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.002 0.0019
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0047 0.0094
Brugia malayi Papain family cysteine protease containing protein 0.0132 0.0839 0.1681
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0717 0.4988 1
Schistosoma mansoni ferritin light chain 0.0026 0.0081 0.0155
Loa Loa (eye worm) hypothetical protein 0.0132 0.0839 0.1681
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0047 0.0089
Brugia malayi cathepsin Z-like cysteine proteinase 0.0132 0.0839 0.1681
Loa Loa (eye worm) cytochrome P450 family protein 0.0053 0.0275 0.0551
Onchocerca volvulus Cathepsin L homolog 0.0132 0.0839 0.1603
Echinococcus granulosus microtubule associated protein 2 0.0741 0.5153 0.5153
Loa Loa (eye worm) hypothetical protein 0.0717 0.4988 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0717 0.4988 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.0839 0.1681
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0717 0.4988 1
Plasmodium vivax unspecified product 0.0237 0.1582 0.3144

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 5.1 mg kg-1 Effective dose required to prevent reserpine ptosis in mice, administered intraperitoneally ChEMBL. 4067998
ED50 (functional) = 12.8 mg kg-1 Effective dose required to potentiate yohimbine hydrochloride induced lethality in mice, administered intraperitoneally ChEMBL. 4067998

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.