Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0058 | 0.2354 | 0.2265 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0922 | 0.0816 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2816 | 0.2816 |
Brugia malayi | RNA binding protein | 0.0066 | 0.2816 | 0.8478 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1069 | 0.3541 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2816 | 0.2816 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0058 | 0.2354 | 0.2265 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.2816 | 0.8478 |
Brugia malayi | Bromodomain containing protein | 0.0073 | 0.3276 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.2816 | 0.2733 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0922 | 0.0816 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.3018 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1326 | 0.4395 |
Echinococcus multilocularis | geminin | 0.0183 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1211 | 0.4014 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0115 | 0.0115 |
Brugia malayi | Bromodomain containing protein | 0.0037 | 0.1064 | 0.2673 |
Schistosoma mansoni | hypothetical protein | 0.0183 | 1 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.0062 | 0.257 | 0.257 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2816 | 0.2816 |
Schistosoma mansoni | hypothetical protein | 0.0183 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.2816 | 0.9332 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2816 | 0.2816 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.2816 | 0.2733 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.2816 | 0.8478 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.2816 | 0.9332 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.2816 | 0.9332 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2816 | 0.2816 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 85 % | Inhibition of Bacillus licheniformis BS3 beta-lactamase assessed as residual activity at 100 uM at pH 7 using phosphate buffer by spectrophotometry | ChEMBL. | 19467869 |
Inhibition (binding) | = 85 % | Inhibition of Pseudomonas aeruginosa OXA10 beta-lactamase assessed as residual activity at 100 uM at pH 5 using acetate buffer by spectrophotometry | ChEMBL. | 19467869 |
Inhibition (binding) | = 86 % | Inhibition of Enterobacter cloacae NMCA beta-lactamase assessed as residual activity at 100 uM at pH 5 using acetate buffer by spectrophotometry | ChEMBL. | 19467869 |
Inhibition (binding) | = 92 % | Inhibition of Pseudomonas aeruginosa OXA10 beta-lactamase assessed as residual activity at 100 uM at pH 7 using phosphate buffer by spectrophotometry | ChEMBL. | 19467869 |
Inhibition (binding) | = 94 % | Inhibition of Pseudomonas aeruginosa VIM4 beta-lactamase assessed as residual activity at 100 uM at pH 7 using HEPES buffer by spectrophotometry | ChEMBL. | 19467869 |
Inhibition (binding) | = 94 % | Inhibition of Enterobacter cloacae P99 beta-lactamase assessed as residual activity at 100 uM at pH 5 using acetate buffer by spectrophotometry | ChEMBL. | 19467869 |
Inhibition (binding) | = 97 % | Inhibition of Bacillus licheniformis BS3 beta-lactamase assessed as residual activity at 100 uM at pH 5 using acetate buffer by spectrophotometry | ChEMBL. | 19467869 |
Inhibition (binding) | = 100 % | Inhibition of Enterobacter cloacae NMCA beta-lactamase assessed as residual activity at 100 uM at pH 7 using phosphate buffer by spectrophotometry | ChEMBL. | 19467869 |
Inhibition (binding) | = 100 % | Inhibition of Enterobacter cloacae P99 beta-lactamase assessed as residual activity at 100 uM at pH 7 using phosphate buffer by spectrophotometry | ChEMBL. | 19467869 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.