Detailed information for compound 1033942

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 418.724 | Formula: C17H19Cl3FN5
  • H donors: 2 H acceptors: 1 LogP: 4.17 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(c(c1)C1C/C(=N\N=C(N)N)/c2c(C1)nccc2C)Cl.Cl.Cl
  • InChi: 1S/C17H17ClFN5.2ClH/c1-9-4-5-22-14-6-10(12-8-11(19)2-3-13(12)18)7-15(16(9)14)23-24-17(20)21;;/h2-5,8,10H,6-7H2,1H3,(H4,20,21,24);2*1H/b23-15+;;
  • InChiKey: KHFWVQWCOYWWPV-RKIARVFCSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Sodium/hydrogen exchanger 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni sodium/hydrogen exchanger Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus multilocularis sodium:hydrogen exchanger Get druggable targets OG5_127664 All targets in OG5_127664
Schistosoma japonicum Sodium/hydrogen exchanger 2, putative Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 Get druggable targets OG5_127664 All targets in OG5_127664
Schistosoma japonicum Sodium/hydrogen exchanger 2, putative Get druggable targets OG5_127664 All targets in OG5_127664
Giardia lamblia Sodium/hydrogen exchanger 3 Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) Get druggable targets OG5_127664 All targets in OG5_127664
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127664 All targets in OG5_127664
Schistosoma mansoni sodium/hydrogen exchanger 2 (nhe2) Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus granulosus sodium:hydrogen exchanger Get druggable targets OG5_127664 All targets in OG5_127664
Onchocerca volvulus Sodium\/hydrogen exchanger homolog Get druggable targets OG5_127664 All targets in OG5_127664
Brugia malayi sodium/hydrogen exchanger 3 family protein Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) Get druggable targets OG5_127664 All targets in OG5_127664
Loa Loa (eye worm) NHE-3 Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) Get druggable targets OG5_127664 All targets in OG5_127664
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127664 All targets in OG5_127664
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127664 All targets in OG5_127664
Onchocerca volvulus Sodium\/hydrogen exchanger homolog Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus granulosus sodium:hydrogen exchanger 2 (nhe2) Get druggable targets OG5_127664 All targets in OG5_127664
Onchocerca volvulus Sodium\/hydrogen exchanger homolog Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus multilocularis sodium:hydrogen exchanger Get druggable targets OG5_127664 All targets in OG5_127664
Schistosoma japonicum ko:K03316 monovalent cation:H+ antiporter, CPA1 family, putative Get druggable targets OG5_127664 All targets in OG5_127664
Loa Loa (eye worm) sodium/hydrogen exchanger 3 family protein Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus granulosus sodium:hydrogen exchanger Get druggable targets OG5_127664 All targets in OG5_127664
Loa Loa (eye worm) sodium/hydrogen exchanger Get druggable targets OG5_127664 All targets in OG5_127664
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis fibrillin 1 0.0052 0.0032 0.004
Trichomonas vaginalis esterase, putative 0.0035 0.0016 0.0024
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0013 0.0013
Trichomonas vaginalis macrophage migration inhibitory factor, mif, putative 0.0173 0.0144 0.0234
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0046 0.0026 0.0033
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0094 0.0071 0.0114
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0476 0.0424 0.0693
Loa Loa (eye worm) hypothetical protein 0.0042 0.0023 0.0023
Plasmodium vivax macrophage migration inhibitory factor, putative 0.0173 0.0144 0.3377
Leishmania major acetyl-CoA synthetase, putative 0.0028 0.001 0.0127
Brugia malayi hypothetical protein 0.0023 0.0006 0.0005
Mycobacterium ulcerans polyketide synthase Pks9 0.005 0.003 0.0682
Loa Loa (eye worm) reprolysin 0.0046 0.0026 0.0026
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2629 0.2416 0.3956
Loa Loa (eye worm) hypothetical protein 0.0038 0.0019 0.0019
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0731 0.066 1
Loa Loa (eye worm) hypothetical protein 0.01 0.0076 0.0076
Echinococcus granulosus Protein kinase C brain isozyme 0.0019 0.0001 0.0001
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0078 0.0057 0.2225
Giardia lamblia Sodium/hydrogen exchanger 3 0.01 0.0076 0.0204
Echinococcus multilocularis dna polymerase eta 0.0019 0.0001 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0476 0.0424 0.0693
Schistosoma mansoni hypothetical protein 0.0031 0.0012 0.0012
Mycobacterium tuberculosis Conserved protein 0.0035 0.0016 0.0353
Trichomonas vaginalis conserved hypothetical protein 0.0476 0.0424 0.0693
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0069 0.0112
Mycobacterium ulcerans oxidoreductase 0.0126 0.01 0.234
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0731 0.066 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0025 0.0025
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0147 0.012 0.1803
Echinococcus granulosus Estrogen regulated protein EP45 0.0023 0.0006 0.0006
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0016 0.0353
Schistosoma mansoni chromatin regulatory protein sir2 0.0108 0.0084 0.0084
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.01 0.0076 0.0095
Leishmania major arginine N-methyltransferase, type I 0.0053 0.0033 0.0482
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.002 0.0003 0.0002
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0036 0.0017 0.0373
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0036 0.0017 0.0373
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0062 0.0042 0.0954
Echinococcus multilocularis serine protease inhibitor 0.0023 0.0006 0.0007
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.002 0.0003 0.0021
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0731 0.066 0.108
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0109 0.0085 0.1287
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0001 0.0001
Onchocerca volvulus 0.0035 0.0016 0.0256
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0008 0.0011
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0476 0.0424 0.0693
Echinococcus granulosus sodium:hydrogen exchanger 0.01 0.0076 0.0076
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0025 0.0031
Schistosoma mansoni hypothetical protein 0.0019 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.002 0.0003 0.0003
Echinococcus multilocularis disintegrin and metalloproteinase 0.0019 0.0002 0.0002
Loa Loa (eye worm) serpin 0.0023 0.0006 0.0005
Plasmodium vivax SET domain protein, putative 0.0088 0.0066 0.1515
Brugia malayi aspartic protease BmAsp-2, identical 0.0038 0.0019 0.0019
Trypanosoma brucei glucosidase, putative 0.0109 0.0085 0.1274
Echinococcus multilocularis neuroendocrine convertase 2 0.6839 0.6311 0.788
Echinococcus multilocularis MAM 0.0072 0.0051 0.0064
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0025 0.0025
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0016 0.0024
Brugia malayi serpin 0.0023 0.0006 0.0005
Echinococcus granulosus c-Jun N-terminal kinases 0.023 0.0197 0.0197
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0085 0.1274
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0108 0.0084 0.1946
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0077 0.0055 0.0055
Loa Loa (eye worm) serpin protein 6 0.0023 0.0006 0.0005
Onchocerca volvulus 0.002 0.0003 0.0038
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0016 0.0353
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0082 0.006 0.1379
Trichomonas vaginalis antibiotic synthetase, putative 0.0028 0.001 0.0014
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0016 0.0024
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0029 0.0011 0.0011
Echinococcus granulosus disintegrin and metalloproteinase 0.0019 0.0002 0.0002
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.001 0.0197
Brugia malayi hypothetical protein 0.006 0.0039 0.0039
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0476 0.0424 0.0693
Brugia malayi Nematode astacin protease protein 30 0.0026 0.0008 0.0008
Brugia malayi von Willebrand factor type A domain containing protein 0.002 0.0003 0.0002
Schistosoma mansoni protein arginine n-methyltransferase 0.0053 0.0033 0.0033
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0026 0.0008 0.0008
Leishmania major hypothetical protein, conserved 0.0034 0.0015 0.0212
Loa Loa (eye worm) fatty acid synthase 0.0078 0.0057 0.0056
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.0069 0.1033
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0476 0.0424 0.0693
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0041 0.0022 0.031
Brugia malayi protein kinase C II. 0.0095 0.0072 0.0072
Schistosoma mansoni alpha-glucosidase 0.0425 0.0377 0.0377
Toxoplasma gondii thioredoxin reductase 0.0047 0.0028 0.0622
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0476 0.0424 0.0693
Leishmania major sir2-family protein-like protein 0.0108 0.0084 0.1252
Echinococcus multilocularis neuropilin (nrp) and tolloid (tll) 0.0026 0.0008 0.001
Brugia malayi jmjC domain containing protein 0.0058 0.0038 0.0038
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.002 0.0003 0.0021
Echinococcus granulosus CUB 0.0026 0.0008 0.0008
Mycobacterium ulcerans polyketide synthase Pks13 0.0116 0.0091 0.2132
Loa Loa (eye worm) sirtuin 4 0.0108 0.0084 0.0084
Giardia lamblia hypothetical protein 0.0052 0.0032 0.0085
Onchocerca volvulus 0.0019 0.0002 0.0023
Brugia malayi Zona pellucida-like domain containing protein 0.002 0.0003 0.0002
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0078 0.0057 0.1306
Plasmodium falciparum plasmepsin V 0.0428 0.038 0.8955
Loa Loa (eye worm) hypothetical protein 0.0118 0.0094 0.0093
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0147 0.012 0.1803
Onchocerca volvulus 0.0034 0.0016 0.0252
Loa Loa (eye worm) transcriptional regulator 0.0108 0.0084 0.0084
Schistosoma mansoni aldehyde dehydrogenase 0.0121 0.0096 0.0096
Toxoplasma gondii histone lysine-specific demethylase 0.0126 0.01 0.2334
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0077 0.0055 0.1279
Onchocerca volvulus 0.0023 0.0006 0.0086
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.001 0.0197
Mycobacterium ulcerans membrane transporter 0.0019 0.0002 0.0008
Echinococcus granulosus lysine specific demethylase 5A 0.0058 0.0038 0.0038
Brugia malayi intermediate filament protein 0.0028 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0044 0.0025 0.0024
Schistosoma mansoni hypothetical protein 0.0044 0.0025 0.0025
Schistosoma mansoni hypothetical protein 0.0053 0.0033 0.0033
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0061 0.0041 0.0931
Echinococcus multilocularis sodium:hydrogen exchanger 7 0.0019 0.0002 0.0002
Mycobacterium ulcerans dehydrogenase 0.0126 0.01 0.234
Onchocerca volvulus 0.0049 0.003 0.0471
Schistosoma mansoni hypothetical protein 0.0065 0.0044 0.0044
Loa Loa (eye worm) transcriptional regulator 0.0108 0.0084 0.0084
Brugia malayi astacin protease protein 30 0.0026 0.0008 0.0008
Plasmodium vivax aspartyl proteinase, putative 0.0038 0.0019 0.0417
Loa Loa (eye worm) hypothetical protein 0.0029 0.0011 0.0011
Echinococcus granulosus sodium:hydrogen exchanger 7 0.0019 0.0002 0.0002
Brugia malayi Glycosyl hydrolases family 31 protein 0.0493 0.044 0.044
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.0245 0.04
Mycobacterium ulcerans NAD-dependent deacetylase 0.0108 0.0084 0.1952
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0108 0.0084 0.0135
Brugia malayi von Willebrand factor type A domain containing protein 0.002 0.0003 0.0002
Toxoplasma gondii rhoptry neck protein RON1 0.0034 0.0016 0.0339
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0053 0.0033 0.0482
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0053 0.0033 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0025 0.0038
Loa Loa (eye worm) hypothetical protein 0.0476 0.0424 0.0424
Schistosoma mansoni hypothetical protein 0.0072 0.0051 0.0051
Toxoplasma gondii type I fatty acid synthase, putative 0.0086 0.0063 0.1457
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0126 0.01 0.2334
Brugia malayi serpin 0.0023 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0034 0.0016 0.0016
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2629 0.2416 0.3956
Onchocerca volvulus 0.0028 0.001 0.015
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0025 0.0038
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0028 0.001 0.0197
Loa Loa (eye worm) hypothetical protein 0.0026 0.0008 0.0008
Onchocerca volvulus 0.067 0.0604 0.9628
Toxoplasma gondii subtilisin SUB12 0.0476 0.0424 1
Leishmania major acetyl-CoA synthetase, putative 0.0028 0.001 0.0127
Trichomonas vaginalis conserved hypothetical protein 0.2153 0.1976 0.3235
Brugia malayi AMP-binding enzyme family protein 0.0094 0.0071 0.0071
Brugia malayi hypothetical protein 0.0034 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0046 0.0026 0.0026
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0044 0.0025 0.0025
Brugia malayi AMP-binding enzyme family protein 0.0028 0.001 0.0009
Echinococcus multilocularis c Jun NH2 terminal kinase 0.023 0.0197 0.0245
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0015 0.0323
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0476 0.0424 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0493 0.044 0.055
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0077 0.0055 0.1271
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0001 0.0001
Brugia malayi NAD-dependent deacetylase SIRT1 0.0108 0.0084 0.0084
Brugia malayi Sex muscle abnormal protein 5 0.0126 0.0101 0.01
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0016 0.0353
Echinococcus multilocularis epidermal growth factor receptor 0.0655 0.059 0.0737
Echinococcus granulosus cubilin 0.0026 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0173 0.0144 0.0144
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0001 0.0001
Echinococcus multilocularis growth factor receptor bound protein 2 0.0126 0.0101 0.0126
Echinococcus granulosus protein kinase c epsilon type 0.0095 0.0072 0.0072
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.002 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0023 0.0006 0.0005
Echinococcus multilocularis discoidin domain containing receptor 2 0.0044 0.0025 0.0031
Loa Loa (eye worm) hypothetical protein 0.0041 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0035 0.0016 0.0016
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0053 0.0033 0.0052
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0022 0.0034
Mycobacterium leprae Probable lipase LipE 0.0035 0.0016 0.0345
Toxoplasma gondii ABC1 family protein 0.0035 0.0016 0.0345
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0109 0.0085 0.0138
Loa Loa (eye worm) oxidoreductase 0.0028 0.001 0.0009
Loa Loa (eye worm) WD40 repeat protein 0.0152 0.0125 0.0125
Mycobacterium ulcerans fatty acid synthase Fas 0.0025 0.0007 0.0139
Echinococcus multilocularis cubilin 0.0026 0.0008 0.001
Toxoplasma gondii aldehyde dehydrogenase 0.0121 0.0096 0.2226
Brugia malayi Bm-MIF-1, identical 0.0173 0.0144 0.0144
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.0245 0.04
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0046 0.0027 0.0027
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.0084 0.1958
Echinococcus granulosus voltage dependent calcium channel subunit 0.002 0.0003 0.0003
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0094 0.0071 0.0071
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0108 0.0084 0.0105
Brugia malayi hypothetical protein 0.0072 0.0051 0.0051
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0069 0.1033
Brugia malayi Immunoglobulin I-set domain containing protein 0.002 0.0003 0.0002
Onchocerca volvulus 0.0476 0.0424 0.6759
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0019 0.0019
Schistosoma mansoni cpg binding protein 0.0031 0.0013 0.0013
Leishmania major 4-coumarate:coa ligase-like protein 0.0094 0.0071 0.1061
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0019 0.0019
Brugia malayi AMP-binding enzyme family protein 0.0028 0.001 0.0009
Schistosoma mansoni hypothetical protein 0.0204 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0072 0.0051 0.0051
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0028 0.0035
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0731 0.066 0.108
Leishmania major 4-coumarate:coa ligase-like protein 0.0094 0.0071 0.1061
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0476 0.0424 0.0693
Brugia malayi Thioredoxin reductase 0.0047 0.0028 0.0028
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0502 0.0448 0.6779
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.0095 0.2222
Schistosoma mansoni hypothetical protein 0.0173 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0178 0.0149 0.0148
Brugia malayi Kelch motif family protein 0.0259 0.0223 0.0223
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0013 0.0285
Schistosoma mansoni serpin 0.0023 0.0006 0.0006
Brugia malayi AMP-binding enzyme family protein 0.0094 0.0071 0.0071
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0025 0.0031
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0109 0.0085 0.0138
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0013 0.0183
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0476 0.0424 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0088 0.0066 0.0066
Loa Loa (eye worm) integrin alpha pat-2 0.0464 0.0413 0.0413
Echinococcus granulosus lysosomal alpha glucosidase 0.0493 0.044 0.044
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.0245 0.04
Loa Loa (eye worm) hypothetical protein 0.0094 0.0071 0.0071
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 0.01 0.0076 0.0076
Schistosoma mansoni dock 0.0044 0.0025 0.0025
Entamoeba histolytica hypothetical protein 0.002 0.0003 0.0033
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0016 0.002
Loa Loa (eye worm) hypothetical protein 0.0023 0.0006 0.0005
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0013 0.0013
Toxoplasma gondii histone deacetylase SIR2-like 0.0108 0.0084 0.1946
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0028 0.001 0.019
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0053 0.0033 0.0745
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0121 0.0096 0.1432
Echinococcus granulosus neuropilin nrp and tolloid tll 0.0026 0.0008 0.0008
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0016 0.0353
Onchocerca volvulus 0.002 0.0003 0.0038
Echinococcus multilocularis nmda type glutamate receptor 0.0109 0.0085 0.0106
Echinococcus multilocularis discoidin domain containing receptor 2 0.0044 0.0025 0.0031
Onchocerca volvulus Sodium\/hydrogen exchanger homolog 0.01 0.0076 0.1213
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0094 0.0071 0.1653
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0073 0.0051 0.0051
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0476 0.0424 0.0693
Brugia malayi hypothetical protein 0.0233 0.0199 0.0199
Trichomonas vaginalis conserved hypothetical protein 0.2153 0.1976 0.3235
Loa Loa (eye worm) hypothetical protein 0.002 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0008 0.0008
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0019 0.0019
Toxoplasma gondii subtilisin SUB10 0.0476 0.0424 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0006 0.0005
Plasmodium vivax acetyl-CoA synthetase, putative 0.0028 0.001 0.019
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0108 0.0084 0.0084
Plasmodium falciparum thioredoxin reductase 0.0047 0.0028 0.0622
Loa Loa (eye worm) hypothetical protein 0.0026 0.0008 0.0008
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0046 0.0027 0.0027
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0476 0.0424 0.0424
Trichomonas vaginalis WD repeat domain, putative 0.0152 0.0125 0.0202
Echinococcus multilocularis geminin 0.0173 0.0144 0.018
Echinococcus granulosus protein arginine methyltransferase 0.0094 0.0071 0.0071
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0476 0.0424 0.0424
Onchocerca volvulus 0.0176 0.0147 0.2345
Loa Loa (eye worm) CUTiclin-Like family member 0.002 0.0003 0.0002
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0094 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0061 0.004 0.004
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0126 0.01 0.234
Brugia malayi CUB domain containing protein 0.0026 0.0008 0.0008
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0476 0.0424 1
Brugia malayi Glutamate receptor 2 precursor 0.0031 0.0012 0.0012
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0618 0.0556 0.0556
Plasmodium vivax hypothetical protein, conserved 0.002 0.0003 0.0021
Brugia malayi hypothetical protein 0.0118 0.0094 0.0093
Loa Loa (eye worm) hypothetical protein 0.0049 0.003 0.003
Trichomonas vaginalis conserved hypothetical protein 0.2153 0.1976 0.3235
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0028 0.001 0.0009
Trypanosoma brucei glycosyl hydrolase-like protein 0.0041 0.0022 0.031
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.0053 0.0033 0.0745
Loa Loa (eye worm) NHE-3 0.01 0.0076 0.0076
Onchocerca volvulus 0.0038 0.0019 0.0304
Trypanosoma cruzi sodium/hydrogen exchanger, putative 0.0019 0.0002 0.0005
Plasmodium vivax apical sushi protein, putative 0.0034 0.0016 0.0339
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0006 0.0113
Echinococcus granulosus membrane bound transcription factor site 1 0.0476 0.0424 0.0424
Loa Loa (eye worm) hypothetical protein 0.0094 0.0071 0.0071
Brugia malayi zinc metalloproteinase toh-2 precursor 0.0026 0.0008 0.0008
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0094 0.0071 0.1653
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0025 0.0038
Onchocerca volvulus 0.002 0.0003 0.0038
Brugia malayi hypothetical protein 0.0023 0.0006 0.0005
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.0069 0.0087
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0108 0.0084 0.0105
Loa Loa (eye worm) hypothetical protein 0.0035 0.0016 0.0016
Echinococcus multilocularis GA binding protein alpha chain 0.0071 0.005 0.0062
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0108 0.0084 0.1264
Toxoplasma gondii F5/8 type C domain-containing protein 0.0044 0.0025 0.0542
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0126 0.01 0.234
Echinococcus granulosus integrin alpha 3 0.0231 0.0198 0.0198
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0085 0.1274
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0013 0.0183
Schistosoma mansoni lamin 0.0028 0.001 0.001
Schistosoma mansoni growth factor receptor-bound protein 0.0126 0.0101 0.0101
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0228 0.0195 0.0194
Echinococcus multilocularis integrin alpha ps 0.0135 0.0109 0.0136
Brugia malayi Integrin beta pat-3 precursor 0.1531 0.1401 0.1401
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0001 0.0001
Onchocerca volvulus 0.0044 0.0025 0.0388
Schistosoma mansoni chromatin regulatory protein sir2 0.0731 0.066 0.066
Loa Loa (eye worm) hypothetical protein 0.0034 0.0016 0.0016
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0267 0.0231 0.0231
Loa Loa (eye worm) endoprotease bli-4 1.0827 1 1
Giardia lamblia Furin precursor putative serine protease 0.2153 0.1976 0.5378
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0001 0.0014
Schistosoma mansoni gabp alpha 0.0071 0.005 0.005
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0028 0.0629
Mycobacterium ulcerans Sir2-like regulatory protein 0.0108 0.0084 0.1952
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.6617 0.6106 0.6106
Loa Loa (eye worm) lectin C-type domain-containing protein 0.0026 0.0008 0.0008
Loa Loa (eye worm) DPY-31 protein 0.0026 0.0008 0.0008
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0731 0.066 1
Onchocerca volvulus 0.0031 0.0013 0.0199
Trypanosoma brucei SIR2-like protein 4, putative 0.0108 0.0084 0.1252
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0094 0.0071 0.1653
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0108 0.0084 0.1264
Echinococcus multilocularis protein kinase c epsilon type 0.0095 0.0072 0.009
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0028 0.001 0.019
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.002 0.0003 0.0003
Loa Loa (eye worm) TK/ROR protein kinase 0.0031 0.0013 0.0012
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0094 0.0071 0.1645
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0025 0.0025
Onchocerca volvulus 0.0034 0.0016 0.0252
Leishmania major hypothetical protein, conserved 0.0019 0.0002 0.0005
Mycobacterium tuberculosis Possible oxidoreductase 0.0126 0.01 0.234
Loa Loa (eye worm) hypothetical protein 0.0094 0.0071 0.0071
Schistosoma mansoni serine protease inhibitors serpins 0.0023 0.0006 0.0006
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0028 0.001 0.0127
Schistosoma mansoni neuropilin (nrp) and tolloid (tll)-like 0.0026 0.0008 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0025 0.0038
Mycobacterium ulcerans beta-lactamase 0.0035 0.0016 0.0353
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0015 0.0212
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0046 0.0027 0.0034
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.019 0.4453
Onchocerca volvulus 0.0088 0.0066 0.1044
Plasmodium falciparum plasmepsin III 0.0038 0.0019 0.0417
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0088 0.0066 0.0066
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0088 0.0066 0.0082
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0121 0.0096 0.2233
Loa Loa (eye worm) hypothetical protein 0.0026 0.0008 0.0008
Brugia malayi hypothetical protein 0.0034 0.0016 0.0016
Brugia malayi neuroendocrine convertase 1 precursor 0.6839 0.6311 0.6311
Loa Loa (eye worm) hypothetical protein 0.007 0.0049 0.0049
Entamoeba histolytica hypothetical protein 0.0052 0.0032 0.0485
Onchocerca volvulus 0.002 0.0003 0.0038
Onchocerca volvulus 0.0034 0.0016 0.0252
Schistosoma mansoni integrin beta subunit 0.0902 0.0818 0.0818
Loa Loa (eye worm) hypothetical protein 0.0298 0.026 0.026
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0028 0.001 0.019
Trichomonas vaginalis alpha-glucosidase, putative 0.0109 0.0085 0.0138
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0046 0.0027 0.0034
Entamoeba histolytica sodium/proton antiporter, putative 0.0019 0.0002 0.0019
Loa Loa (eye worm) hypothetical protein 0.007 0.0049 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0032 0.0051
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0036 0.0017 0.0373
Plasmodium falciparum subtilisin-like protease 2 0.0476 0.0424 1
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0025 0.0038
Chlamydia trachomatis protoporphyrinogen oxidase 0.0126 0.01 1
Echinococcus granulosus protein arginine N methyltransferase 8 0.0094 0.0071 0.0071
Schistosoma mansoni cpg binding protein 0.0029 0.0011 0.0011
Toxoplasma gondii rhoptry neck protein RON9 0.0034 0.0016 0.0339
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0077 0.0055 0.1271
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0094 0.0071 0.0071
Mycobacterium leprae PROBABLE CONSERVED TRANSMEMBRANE PROTEIN 0.0044 0.0025 0.0542
Schistosoma mansoni chromatin regulatory protein sir2 0.0731 0.066 0.066
Echinococcus multilocularis voltage dependent calcium channel subunit 0.002 0.0003 0.0003
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0052 0.0032 0.0041
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0476 0.0424 0.0693
Leishmania major arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 0.0053 0.0033 0.0482
Schistosoma mansoni DNA polymerase eta 0.0019 0.0001 0.0001
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0038 0.0019 0.0019
Schistosoma mansoni sodium/hydrogen exchanger 3 (nhe3) 0.0019 0.0002 0.0002
Loa Loa (eye worm) glutaminase 2 0.0264 0.0228 0.0228
Echinococcus granulosus mitochondrial sodium:hydrogen exchanger 9B2 0.0019 0.0002 0.0002
Echinococcus multilocularis glutamate receptor 2 0.0046 0.0027 0.0034
Loa Loa (eye worm) hypothetical protein 0.421 0.3878 0.3878
Echinococcus granulosus Estrogen regulated protein EP45 0.0023 0.0006 0.0006
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2629 0.2416 0.3956
Brugia malayi EGF-like domain containing protein 0.0049 0.003 0.003
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.001 0.0009
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0731 0.066 0.0825
Brugia malayi GCC2 and GCC3 family protein 0.0043 0.0024 0.0024
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.002 0.0003 0.0021
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.001 0.019
Plasmodium falciparum plasmepsin VII 0.0038 0.0019 0.0417
Schistosoma mansoni serine protease inhibitors serpins 0.0023 0.0006 0.0006
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0108 0.0084 0.0084
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0022 0.0034
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0078 0.0057 0.1306
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0016 0.0016
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1469 0.1343 0.1343
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0046 0.0027 0.0034
Brugia malayi von Willebrand factor type A domain containing protein 0.002 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.002 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0065 0.0044 0.0044
Toxoplasma gondii protease inhibitor PI1 0.0023 0.0006 0.0093
Entamoeba histolytica PH domain containing protein kinase, putative 0.0078 0.0056 0.0841
Leishmania major 4-coumarate:coa ligase-like protein 0.0094 0.0071 0.1061
Brugia malayi ADAM-TS Spacer 1 family protein 0.0027 0.0009 0.0009
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0028 0.001 0.014
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.0245 0.04
Echinococcus multilocularis serine protease inhibitor 0.0023 0.0006 0.0007
Echinococcus multilocularis Tolloid protein 1 0.0026 0.0008 0.001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0476 0.0424 0.0693
Toxoplasma gondii hypothetical protein 0.0049 0.003 0.0664
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0028 0.001 0.0197
Echinococcus granulosus lysine specific histone demethylase 1A 0.0618 0.0556 0.0556
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.002 0.0003 0.0019
Plasmodium vivax thrombospondin-related anonymous protein 0.002 0.0003 0.0021
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0108 0.0084 0.0135
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0001
Onchocerca volvulus 0.0035 0.0016 0.0256
Loa Loa (eye worm) hypothetical protein 0.0033 0.0015 0.0014
Brugia malayi EGF-like domain containing protein 0.0049 0.003 0.003
Echinococcus multilocularis discoidin domain containing receptor 2 0.0044 0.0025 0.0031
Echinococcus granulosus intermediate filament protein 0.0028 0.001 0.001
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0078 0.0057 0.5528
Echinococcus multilocularis 0.8674 0.8008 1
Brugia malayi Kringle domain containing protein 0.0031 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.01 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 1.0827 1 1
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0094 0.0071 0.0114
Giardia lamblia hypothetical protein 0.0049 0.003 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.2153 0.1976 0.3235
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0108 0.0084 0.0135
Toxoplasma gondii bicoid-interacting protein BIN3 0.0053 0.0033 0.0745
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0041 0.0022 0.0344
Echinococcus granulosus adam 0.0109 0.0085 0.0085
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0476 0.0424 1
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0731 0.066 1
Mycobacterium ulcerans acetyl-CoA synthetase 0.0028 0.001 0.0197
Mycobacterium ulcerans thioesterase TesA 0.0066 0.0045 0.1042
Brugia malayi transcriptional regulator, Sir2 family protein 0.0731 0.066 0.066
Echinococcus multilocularis lysosomal alpha glucosidase 0.0493 0.044 0.055
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.2629 0.2416 0.2416
Loa Loa (eye worm) beta-lactamase 0.0035 0.0016 0.0016
Schistosoma mansoni protein kinase 0.0127 0.0101 0.0101
Giardia lamblia Hypothetical protein 0.0731 0.066 0.1795
Onchocerca volvulus 0.0023 0.0006 0.0086
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0077 0.0055 0.1271
Schistosoma mansoni hypothetical protein 0.0053 0.0033 0.0033
Schistosoma mansoni alpha glucosidase 0.0109 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.002 0.0003 0.0002
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0116 0.0091 0.2132
Brugia malayi hypothetical protein 0.002 0.0003 0.0002
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.002 0.0003 0.0019
Loa Loa (eye worm) hypothetical protein 0.0023 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.002 0.0003 0.0002
Brugia malayi sodium/hydrogen exchanger 3 family protein 0.01 0.0076 0.0076
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.0069 0.0069
Brugia malayi beta-lactamase family protein 0.0035 0.0016 0.0016
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0074 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0027 0.0009 0.0009
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0022 0.0324
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.002 0.0003 1
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0028 0.0404
Schistosoma mansoni ets-related 0.0216 0.0184 0.0184
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0057 0.0037 0.0842
Schistosoma mansoni chromatin regulatory protein sir2 0.0108 0.0084 0.0084
Schistosoma mansoni SWI/SNF complex-related 0.0052 0.0032 0.0032
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0015 0.0212
Brugia malayi Furin-like cysteine rich region family protein 0.0655 0.059 0.059
Onchocerca volvulus 0.0102 0.0078 0.1247
Loa Loa (eye worm) hypothetical protein 0.0088 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0034 0.0016 0.0016
Brugia malayi BmSERPIN 0.0023 0.0006 0.0005
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0028 0.001 0.0197
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.6617 0.6106 1
Brugia malayi jmjC domain containing protein 0.0057 0.0037 0.0036
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.001 0.0197
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0023 0.0006 0.0005
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0044 0.0025 0.0038
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0034 0.0015 0.0019
Plasmodium falciparum thrombospondin-related anonymous protein 0.002 0.0003 0.0021
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0069 0.0112
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0476 0.0424 0.0693
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0038 0.0019 0.0019
Brugia malayi Protein kinase domain containing protein 0.0031 0.0013 0.0012
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0025 0.0007 0.0139
Loa Loa (eye worm) hypothetical protein 0.0029 0.0011 0.0011
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0476 0.0424 0.0693
Leishmania major silent information regulator 2, putative 0.0731 0.066 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0041 0.0022 0.0034
Schistosoma mansoni chromatin regulatory protein sir2 0.0731 0.066 0.066
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.002 0.0003 0.0021
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0126 0.01 0.234
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0001
Leishmania major glycosyl hydrolase-like protein 0.0041 0.0022 0.031
Mycobacterium tuberculosis Probable reductase 0.0108 0.0084 0.1958
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0016 0.0353
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0108 0.0084 0.0225
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0044 0.0025 0.0031
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0022 0.0034
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.6617 0.6106 1
Echinococcus granulosus epidermal growth factor receptor 0.0655 0.059 0.059
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.001 0.0197
Echinococcus granulosus cubilin 0.0026 0.0008 0.0008
Schistosoma mansoni amine oxidase 0.0126 0.01 0.01
Echinococcus multilocularis protoporphyrinogen oxidase 0.0126 0.01 0.0125
Toxoplasma gondii subtilisin SUB1 0.0476 0.0424 1
Mycobacterium tuberculosis Probable conserved integral membrane transport protein YjcE 0.0019 0.0002 0.0008
Loa Loa (eye worm) TK/EGFR protein kinase 0.0655 0.059 0.059
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.2153 0.1976 0.3235
Leishmania major trypanothione reductase 0.0047 0.0028 0.0404
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0028 0.001 0.0127
Mycobacterium leprae Possible secreted protease 0.0476 0.0424 1
Echinococcus granulosus serine protease inhibitor 0.0023 0.0006 0.0006
Brugia malayi Angiotensin-converting enzyme family protein 0.0621 0.0558 0.0558
Schistosoma mansoni hypothetical protein 0.0026 0.0008 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0476 0.0424 0.0693
Brugia malayi CUB domain containing protein 0.0026 0.0008 0.0008
Toxoplasma gondii F5/8 type C domain-containing protein 0.0044 0.0025 0.0542
Mycobacterium tuberculosis Conserved protein 0.0035 0.0016 0.0353
Loa Loa (eye worm) hypothetical protein 0.0023 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.002 0.0003 0.0002
Echinococcus granulosus dnaJ subfamily B 0.0418 0.0371 0.0371
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0013 0.0013
Plasmodium vivax hypothetical protein, conserved 0.0126 0.01 0.2334
Trichomonas vaginalis conserved hypothetical protein 0.0476 0.0424 0.0693
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0082 0.006 0.1379
Loa Loa (eye worm) hypothetical protein 0.0026 0.0008 0.0008
Brugia malayi beta-lactamase 0.0035 0.0016 0.0016
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0038 0.0038
Brugia malayi latrophilin 2 splice variant baaae 0.0204 0.0173 0.0172
Schistosoma mansoni hypothetical protein 0.0031 0.0013 0.0013
Echinococcus granulosus C type lectin domian containing protein 0.0034 0.0016 0.0016
Echinococcus granulosus glutamate receptor 2 0.0046 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0052 0.0032 0.0032
Echinococcus granulosus discoidin domain containing receptor 2 0.0044 0.0025 0.0025
Echinococcus multilocularis 0.0126 0.01 0.0125
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0476 0.0424 0.0424
Brugia malayi von Willebrand factor type A domain containing protein 0.002 0.0003 0.0002
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.002 0.0003 0.0019
Loa Loa (eye worm) CUTiclin family member 0.002 0.0003 0.0002
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.001 0.0197
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0074 0.0052 0.0052
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0028 0.0028
Brugia malayi hypothetical protein 0.0038 0.0019 0.0019
Leishmania major macrophage migration inhibitory factor-like protein 0.0173 0.0144 0.217
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0109 0.0085 0.1287
Loa Loa (eye worm) hypothetical protein 0.0038 0.0019 0.0019
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0016 0.0353
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0476 0.0424 0.0424
Brugia malayi von Willebrand factor type A domain containing protein 0.002 0.0003 0.0002
Trichomonas vaginalis hypothetical protein 0.2153 0.1976 0.3235
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0001 0.0001
Schistosoma mansoni acetyl-CoA synthetase 0.0028 0.001 0.001
Echinococcus multilocularis chromatin regulatory protein sir2 0.0731 0.066 0.0825
Mycobacterium ulcerans glutaminase 0.0264 0.0228 0.5369
Plasmodium vivax LCCL domain-containing protein 0.0044 0.0025 0.0542
Entamoeba histolytica macrophage migration inhibitory factor-like protein 0.0173 0.0144 0.2181
Plasmodium falciparum LCCL domain-containing protein 0.0044 0.0025 0.0542
Echinococcus granulosus chromatin regulatory protein sir2 0.0731 0.066 0.066
Toxoplasma gondii aspartyl protease ASP3 0.0038 0.0019 0.0417
Giardia lamblia High cysteine membrane protein Group 2 0.3988 0.3673 1
Toxoplasma gondii type I fatty acid synthase, putative 0.0057 0.0036 0.0823
Onchocerca volvulus Putative cubilin 0.0035 0.0016 0.0257
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0668 0.0602 0.0602
Brugia malayi von Willebrand factor type A domain containing protein 0.002 0.0003 0.0002
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0476 0.0424 1
Echinococcus multilocularis C type lectin domian containing protein 0.0034 0.0016 0.002
Entamoeba histolytica acyl-coA synthetase, putative 0.0094 0.0071 0.1073
Brugia malayi serpin precursor 0.0023 0.0006 0.0005
Echinococcus multilocularis dnaJ subfamily B 0.0418 0.0371 0.0463
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.2153 0.1976 0.3235
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0259 0.0223 0.0223
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0476 0.0424 0.0424
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0121 0.0096 0.012
Loa Loa (eye worm) hepatopoietin HPO2 0.0034 0.0015 0.0015
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 1.0827 1 1
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.002 0.0003 0.0003
Brugia malayi isocitrate dehydrogenase 0.0032 0.0013 0.0013
Toxoplasma gondii histone deacetylase SIR2 0.0108 0.0084 0.1946
Loa Loa (eye worm) glutathione reductase 0.0047 0.0028 0.0028
Schistosoma mansoni serine protease inhibitors serpins 0.0023 0.0006 0.0006
Trypanosoma cruzi protein arginine n-methyltransferase 7 0.0053 0.0033 0.0482
Giardia lamblia Transcriptional regulator, Sir2 family 0.0108 0.0084 0.0225
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0094 0.0071 0.1645
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.001 0.0197
Toxoplasma gondii F5/8 type C domain-containing protein 0.0044 0.0025 0.0542
Trichomonas vaginalis alpha-glucosidase, putative 0.0109 0.0085 0.0138
Loa Loa (eye worm) hypothetical protein 0.007 0.0049 0.0049
Trypanosoma cruzi subtilisin peptidase 0.0476 0.0424 0.6416
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0013 0.0278
Schistosoma mansoni hypothetical protein 0.0094 0.0071 0.0071
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0077 0.0055 0.1279
Loa Loa (eye worm) hypothetical protein 0.0228 0.0195 0.0194
Onchocerca volvulus 0.0028 0.001 0.015
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0013 0.0017
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0015 0.0323
Loa Loa (eye worm) hypothetical protein 0.0126 0.01 0.01
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0016 0.0016
Echinococcus granulosus methyltransferase protein 5 0.0053 0.0033 0.0033
Plasmodium vivax subtilisin-like protease 2, putative 0.0476 0.0424 1
Echinococcus multilocularis c4b binding protein beta chain 0.0034 0.0016 0.002
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.01 0.0076 0.0095
Schistosoma mansoni intermediate filament proteins 0.0028 0.001 0.001
Echinococcus granulosus serine:threonine protein kinase N2 0.0078 0.0056 0.0056
Plasmodium falciparum macrophage migration inhibitory factor 0.0173 0.0144 0.3377
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0138 0.0112 0.2604
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0028 0.001 0.001
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0282 0.0245 0.371
Echinococcus granulosus GPCR family 2 0.0094 0.0071 0.0071
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.001 0.0197
Plasmodium falciparum LCCL domain-containing protein 0.0044 0.0025 0.0542
Brugia malayi hypothetical protein 0.0034 0.0016 0.0016
Loa Loa (eye worm) CUB domain-containing protein 0.0026 0.0008 0.0008
Echinococcus granulosus histone lysine methyltransferase setb 0.0088 0.0066 0.0066
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0147 0.012 0.1803
Onchocerca volvulus 0.0026 0.0008 0.0125
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0025 0.0025
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2629 0.2416 0.3956
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0061 0.0041 0.0924
Mycobacterium ulcerans hypothetical protein 0.0094 0.0071 0.1653
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.001 0.0009
Echinococcus granulosus cpg binding protein 0.0031 0.0013 0.0013
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0088 0.0066 0.0082
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0016 0.0353
Entamoeba histolytica hypothetical protein, conserved 0.002 0.0003 0.0033
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0069 0.0112
Echinococcus granulosus plasminogen activator inhibitor 2 0.0023 0.0006 0.0006
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0013 0.0278
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0082 0.006 0.1372
Echinococcus multilocularis protein jagged 2 0.0049 0.003 0.0037
Loa Loa (eye worm) hypothetical protein 0.0049 0.003 0.003
Giardia lamblia Serpin 1 0.0023 0.0006 0.0012
Onchocerca volvulus 0.0039 0.0021 0.0326
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0127 0.0101 0.0126
Schistosoma mansoni c4b-binding protein beta chain 0.0034 0.0016 0.0016
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.0069 0.0069
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0069 0.0112
Echinococcus granulosus Tolloid protein 1 0.0026 0.0008 0.0008
Onchocerca volvulus 0.0019 0.0002 0.0023
Plasmodium falciparum plasmepsin IX 0.0038 0.0019 0.0417
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0108 0.0084 0.1252
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0108 0.0084 0.1952
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0031 0.0012 0.0015
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0138 0.0112 0.2609
Brugia malayi Protein arginine N-methyltransferase 0.0053 0.0033 0.0033
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0027 0.0042
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.002 0.0003 0.0002
Echinococcus multilocularis mitochondrial sodium:hydrogen exchanger 9B2 0.0019 0.0002 0.0002
Echinococcus multilocularis lamin dm0 0.0028 0.001 0.0012
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0618 0.0556 0.0694
Loa Loa (eye worm) hypothetical protein 0.0618 0.0556 0.0556
Mycobacterium ulcerans polyketide synthase 0.0082 0.006 0.1379
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0038 0.0019 0.0024
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0108 0.0084 0.0135
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.0046 0.1048
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0028 0.001 0.0127
Mycobacterium ulcerans thioesterase 0.0066 0.0045 0.1042
Schistosoma mansoni neuropilin (nrp) and tolloid (tll)-like 0.0026 0.0008 0.0008
Schistosoma mansoni cathepsin D (A01 family) 0.0038 0.0019 0.0019
Loa Loa (eye worm) intermediate filament protein 0.0028 0.001 0.0009
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.0084 0.1951
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0731 0.066 0.066
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0016 0.0353
Loa Loa (eye worm) TK/ALK protein kinase 0.0072 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0072 0.0051 0.0051
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0036 0.0017 0.0373
Brugia malayi AMP-binding enzyme family protein 0.0028 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0166 0.0138 0.0137
Echinococcus granulosus furin 1.0827 1 1
Brugia malayi serpin (BmSERPIN) 0.0023 0.0006 0.0005
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.0094 0.0071 0.0071
Brugia malayi Zona pellucida-like domain containing protein 0.002 0.0003 0.0002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.0046 0.1048
Brugia malayi hypothetical protein 0.0034 0.0016 0.0016
Plasmodium falciparum von Willebrand factor A domain-related protein 0.002 0.0003 0.0021
Echinococcus multilocularis collagen alpha 1(VII) chain 0.002 0.0003 0.0003
Brugia malayi hypothetical protein 0.0034 0.0016 0.0016
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0108 0.0084 0.0135
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0025 0.0025
Onchocerca volvulus 0.0034 0.0016 0.0252
Toxoplasma gondii kringle domain-containing protein 0.0031 0.0013 0.0261
Brugia malayi Fli-1 protein 0.0216 0.0184 0.0184
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.6617 0.6106 0.7624
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0069 0.0112
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0094 0.0071 0.0071
Brugia malayi Calcium binding EGF domain containing protein 0.0035 0.0016 0.0016
Trichomonas vaginalis hypothetical protein 0.0044 0.0025 0.0038
Onchocerca volvulus 0.0166 0.0138 0.2192
Loa Loa (eye worm) hypothetical protein 0.002 0.0003 0.0002
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.002 0.0003 0.0003
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0046 0.0026 0.0026
Echinococcus multilocularis protein arginine methyltransferase 0.0094 0.0071 0.0089
Echinococcus multilocularis sodium:hydrogen exchanger 0.01 0.0076 0.0095
Mycobacterium ulcerans lipase LipD 0.0035 0.0016 0.0353
Loa Loa (eye worm) hypothetical protein 0.0028 0.001 0.0009
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0041 0.0022 0.031
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.002 0.0003 0.0019
Onchocerca volvulus 0.0029 0.0011 0.0176
Toxoplasma gondii subtilisin SUB9 0.0476 0.0424 1
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0038 0.0019 0.0019
Mycobacterium ulcerans hypothetical protein 0.0035 0.0016 0.0353
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0015 0.0212
Giardia lamblia Tenascin precursor 0.0049 0.003 0.0077
Plasmodium vivax acyl-CoA synthetase, putative 0.007 0.0049 0.1125
Mycobacterium tuberculosis Conserved hypothetical protein 0.0126 0.01 0.234
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.006 0.0039 0.0039
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0039 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.002 0.0003 0.0002
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0668 0.0602 0.0752
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0013 0.0183
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0019 0.0002 0.0002
Onchocerca volvulus Fatty acid synthase homolog 0.0143 0.0117 0.1857
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0046 0.0026 0.0026
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0016 0.0353
Plasmodium falciparum plasmepsin IV 0.0038 0.0019 0.0417
Onchocerca volvulus 0.0034 0.0016 0.0252
Trichomonas vaginalis antibiotic synthetase, putative 0.0028 0.001 0.0014
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.002 0.0003 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.2153 0.1976 0.3235
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.002 0.0003 0.0021
Echinococcus multilocularis sodium:hydrogen exchanger 0.01 0.0076 0.0095
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0035 0.0016 0.0016
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0476 0.0424 0.0693
Loa Loa (eye worm) hypothetical protein 0.002 0.0003 0.0002
Plasmodium falciparum plasmepsin VI 0.0038 0.0019 0.0417
Onchocerca volvulus 0.0023 0.0006 0.0086
Entamoeba histolytica hypothetical protein 0.0147 0.012 0.1815
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0037 0.0046
Echinococcus granulosus glutamate NMDA receptor subunit 0.0258 0.0223 0.0223
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.005 0.003 0.0674
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.001 0.0009
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0016 0.0024
Echinococcus multilocularis protein will die slowly 0.0152 0.0125 0.0156
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0025 0.0038
Loa Loa (eye worm) hypothetical protein 0.0072 0.0051 0.0051
Entamoeba histolytica hypothetical protein, conserved 0.0108 0.0084 0.1264
Schistosoma mansoni site-1 peptidase (S08 family) 0.0476 0.0424 0.0424
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.0095 0.2222
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0013 0.0183
Brugia malayi EGF-like domain containing protein 0.0049 0.003 0.003
Schistosoma mansoni sodium/hydrogen exchanger 0.01 0.0076 0.0076
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0052 0.0032 0.0032
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0126 0.01 0.01
Loa Loa (eye worm) sodium-hydrogen exchanger NHE1 0.0019 0.0002 0.0001
Schistosoma mansoni discoidin domain receptor 0.0044 0.0025 0.0025
Schistosoma mansoni glutamate receptor kainate 0.0031 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0104 0.008 0.008
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0026 0.0008 0.0008
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0094 0.0071 0.0089
Schistosoma mansoni hypothetical protein 0.0026 0.0008 0.0008
Loa Loa (eye worm) zinc metalloproteinase toh-2 0.0026 0.0008 0.0008
Toxoplasma gondii aspartyl protease ASP1 0.0038 0.0019 0.0417
Loa Loa (eye worm) hypothetical protein 0.01 0.0076 0.0076
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0049 0.003 0.0047
Loa Loa (eye worm) hypothetical protein 0.0026 0.0008 0.0008
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0016 0.0227
Echinococcus granulosus discoidin domain containing receptor 2 0.0044 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0135 0.0109 0.0108
Echinococcus granulosus lamin 0.0028 0.001 0.001
Onchocerca volvulus 0.0034 0.0016 0.0252
Schistosoma mansoni lamin 0.0028 0.001 0.001
Loa Loa (eye worm) aspartyl protease 6 0.0038 0.0019 0.0019
Giardia lamblia Macrophage migration inhibitory factor 0.0173 0.0144 0.039
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0015 0.0323
Schistosoma mansoni hypothetical protein 0.0072 0.0051 0.0051
Schistosoma mansoni microtubule-associated protein tau 0.2756 0.2534 0.2534
Schistosoma mansoni integrin alpha-ps 0.007 0.0049 0.0049
Brugia malayi glutaminase DH11.1 0.0264 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0035 0.0016 0.0016
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0476 0.0424 1
Schistosoma mansoni hypothetical protein 0.0019 0.0002 0.0002
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0022 0.0034
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0022 0.0034
Brugia malayi Ets-domain containing protein 0.0071 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0027 0.0009 0.0009
Schistosoma mansoni glutaminase 0.0264 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0023 0.0006 0.0005
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0116 0.0091 0.2132
Brugia malayi Will die slowly protein 0.0152 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0126 0.01 0.01
Echinococcus granulosus tissue type plasminogen activator 0.0031 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0034 0.0016 0.0016
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0044 0.0025 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0025 0.0038
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.2153 0.1976 0.3235
Echinococcus granulosus lysine specific histone demethylase 1A 0.0126 0.01 0.01
Echinococcus multilocularis serine:threonine protein kinase N2 0.0087 0.0064 0.0081
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0071 0.005 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0032 0.0051
Loa Loa (eye worm) acyl carrier protein 0.0037 0.0018 0.0018
Echinococcus multilocularis Furin 1 0.2629 0.2416 0.3017
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0476 0.0424 0.0693
Schistosoma mansoni kinase 0.0047 0.0028 0.0028
Giardia lamblia High cysteine protein 0.0049 0.003 0.0077
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0476 0.0424 0.0693
Loa Loa (eye worm) hypothetical protein 0.0023 0.0006 0.0005
Brugia malayi Latrophilin receptor protein 2 0.0094 0.0071 0.0071
Brugia malayi Zinc metalloproteinase toh-2 precursor 0.0026 0.0008 0.0008
Treponema pallidum fructose-bisphosphate aldolase 0.0282 0.0245 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0013 0.0012
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0108 0.0084 0.0084
Toxoplasma gondii subtilisin SUB8 0.0476 0.0424 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0077 0.0055 0.1264
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.0095 0.2222
Mycobacterium ulcerans Type I modular polyketide synthase 0.0077 0.0055 0.1271
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0016 0.0016
Trichomonas vaginalis glutaminase, putative 0.0264 0.0228 0.0372
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0016 0.0345
Schistosoma mansoni dihydroceramide desaturase 0.0019 0.0002 0.0002
Leishmania major macrophage migration inhibitory factor-like protein 0.0173 0.0144 0.217
Brugia malayi CXXC zinc finger family protein 0.0029 0.0011 0.0011
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0016 0.0016
Echinococcus multilocularis integrin alpha ps 0.0065 0.0044 0.0055
Brugia malayi transcriptional regulator, Sir2 family protein 0.0108 0.0084 0.0084
Schistosoma mansoni hypothetical protein 0.0026 0.0008 0.0008
Echinococcus granulosus nmda type glutamate receptor 0.0109 0.0085 0.0085
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0108 0.0084 0.1252
Brugia malayi transcriptional regulator, Sir2 family protein 0.0108 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0038 0.0019 0.0019
Brugia malayi EGF-like domain containing protein 0.0049 0.003 0.003
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0493 0.044 0.044
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.001 0.0197
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0022 0.0034
Echinococcus granulosus glutamate receptor subunit protein glur 0.0031 0.0012 0.0012
Schistosoma mansoni cathepsin D (A01 family) 0.0038 0.0019 0.0019
Trypanosoma brucei trypanothione reductase 0.0047 0.0028 0.0404
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.0095 0.2215
Toxoplasma gondii subtilisin SUB2 0.0476 0.0424 1
Brugia malayi Suppressor of lurcher protein 1 precursor 0.0026 0.0008 0.0008
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 0.01 0.0076 0.0076
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0476 0.0424 0.0693
Loa Loa (eye worm) hypothetical protein 0.007 0.0049 0.0049
Leishmania major hypothetical protein, conserved 0.0035 0.0016 0.0227
Brugia malayi SWIRM domain containing protein 0.0052 0.0032 0.0032
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0044 0.0025 0.0548
Echinococcus multilocularis Estrogen regulated protein EP45 0.0023 0.0006 0.0007
Loa Loa (eye worm) apoptosis regulator protein 0.0053 0.0033 0.0033
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0053 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0028 0.001 0.0009
Plasmodium vivax hypothetical protein, conserved 0.0108 0.0084 0.1946
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0001 0.0002
Echinococcus multilocularis integrin beta 2 0.1134 0.1034 0.1291
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0138 0.0112 0.2609
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0038 0.0038
Toxoplasma gondii subtilisin SUB4 0.0476 0.0424 1
Trichomonas vaginalis conserved hypothetical protein 0.2153 0.1976 0.3235
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.0019 0.0002 0.0017
Schistosoma mansoni chromatin regulatory protein sir2 0.0108 0.0084 0.0084
Echinococcus multilocularis glutamate receptor 2 0.0031 0.0012 0.0015
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.005 0.003 0.0682
Loa Loa (eye worm) hypothetical protein 0.0204 0.0173 0.0172
Trypanosoma cruzi UDP-galactopyranose mutase 0.0126 0.01 0.1501
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.0044 0.0025 0.0549
Onchocerca volvulus 0.0023 0.0006 0.0086
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0094 0.0071 0.1647
Schistosoma mansoni amine oxidase 0.0126 0.01 0.01
Toxoplasma gondii serpin (serine proteinase inhibitor) superfamily protein 0.0023 0.0006 0.0093
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.0081 0.0059 0.0073
Brugia malayi Glutamate receptor 1 precursor 0.0031 0.0012 0.0012
Brugia malayi Eukaryotic aspartyl protease family protein 0.0038 0.0019 0.0019
Echinococcus granulosus integrin beta 2 0.1134 0.1034 0.1034
Brugia malayi CUB domain containing protein 0.0026 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.002 0.0003 0.0003
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0031 0.0012 0.0015
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0046 0.0026 0.0026
Mycobacterium ulcerans acyl-CoA synthetase 0.0094 0.0071 0.1653
Loa Loa (eye worm) hypothetical protein 0.002 0.0003 0.0002
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0077 0.0055 0.1271
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0126 0.01 0.2334
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0028 0.001 0.0127
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0031 0.0012 0.0012
Entamoeba histolytica elongation factor-2 kinase, putative 0.002 0.0003 0.0033
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0108 0.0084 0.0135
Loa Loa (eye worm) hypothetical protein 0.0035 0.0016 0.0016
Onchocerca volvulus Sodium\/hydrogen exchanger homolog 0.01 0.0076 0.1213
Brugia malayi von Willebrand factor type A domain containing protein 0.002 0.0003 0.0002
Brugia malayi Calcitonin receptor-like protein seb-1 0.0298 0.026 0.026
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0016 0.0227
Trichomonas vaginalis conserved hypothetical protein 0.0476 0.0424 0.0693
Schistosoma mansoni chromatin regulatory protein sir2 0.0108 0.0084 0.0084
Mycobacterium leprae Polyketide synthase Pks13 0.0116 0.0091 0.2125
Echinococcus granulosus sodium:hydrogen exchanger 0.01 0.0076 0.0076
Echinococcus granulosus geminin 0.0173 0.0144 0.0144
Mycobacterium ulcerans polyketide synthase MbtC 0.002 0.0003 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0025 0.0038
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0088 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0049 0.003 0.003
Schistosoma mansoni ATP-binding cassette transporter 0.0031 0.0012 0.0012
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0016 0.0345
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0038 0.0019 0.0417
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0036 0.0017 0.0373
Schistosoma mansoni hypothetical protein 0.0094 0.0071 0.0071
Schistosoma mansoni cpg binding protein 0.0031 0.0013 0.0013
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0094 0.0071 0.1647
Giardia lamblia Sirtuin type 2 0.0108 0.0084 0.0225
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0027 0.0042
Toxoplasma gondii macrophage migration inhibitory factor, putative 0.0173 0.0144 0.3377
Brugia malayi Sodium/hydrogen exchanger 8 0.0019 0.0002 0.0001
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0028 0.001 0.0127
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0028 0.001 0.0127
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0053 0.0033 0.0033
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.007 0.0049 0.1132
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0298 0.026 0.026
Schistosoma mansoni sodium/hydrogen exchanger 2 (nhe2) 0.01 0.0076 0.0076
Echinococcus multilocularis microtubule associated protein 2 0.2756 0.2534 0.3164
Brugia malayi Protein kinase domain containing protein 0.0044 0.0025 0.0024
Trypanosoma brucei protein arginine n-methyltransferase 7 0.0053 0.0033 0.0482
Schistosoma mansoni glutamate receptor kainate 0.0031 0.0012 0.0012
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0108 0.0084 0.1252
Loa Loa (eye worm) Carm1-pending protein 0.0053 0.0033 0.0033
Echinococcus multilocularis NMDA receptor 0.0031 0.0012 0.0015
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0037 0.0046
Schistosoma mansoni serine protease inhibitors serpins 0.0023 0.0006 0.0006
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.002 0.0003 0.0003
Schistosoma mansoni integrin alpha 0.0301 0.0262 0.0262
Schistosoma mansoni hypothetical protein 0.0418 0.0371 0.0371
Brugia malayi von Willebrand factor type A domain containing protein 0.002 0.0003 0.0002
Plasmodium falciparum plasmepsin II 0.0038 0.0019 0.0417
Brugia malayi Protein kinase domain containing protein 0.0072 0.0051 0.0051
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0015 0.0212
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0109 0.0085 0.0085
Echinococcus granulosus microtubule associated protein 2 0.2756 0.2534 0.2534
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0108 0.0084 0.0135
Brugia malayi serpin 0.0023 0.0006 0.0005
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0028 0.001 0.019
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0036 0.0017 0.0373
Plasmodium vivax subtilisin-like serine protease, putative 0.0476 0.0424 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0088 0.0066 0.1515
Onchocerca volvulus 0.0285 0.0248 0.395
Plasmodium vivax NAD-dependent deacetylase, putative 0.0108 0.0084 0.1946
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0016 0.0227
Mycobacterium ulcerans potassium/proton antiporter 0.0019 0.0002 0.0008
Plasmodium vivax aspartyl protease, putative 0.0038 0.0019 0.0417
Mycobacterium tuberculosis Probable thioesterase TesA 0.0066 0.0045 0.1042
Echinococcus granulosus MAM 0.0072 0.0051 0.0051
Mycobacterium leprae Probable polyketide synthase Pks1 0.0082 0.006 0.1372
Schistosoma mansoni glutamate receptor NMDA 0.0258 0.0223 0.0223
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0013 0.0183
Mycobacterium ulcerans acyl-CoA synthetase 0.0094 0.0071 0.1653
Plasmodium falciparum subtilisin-like protease 1 0.0476 0.0424 1
Giardia lamblia Tenascin-like 0.0049 0.003 0.0077
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0037 0.0037
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.0245 0.04
Onchocerca volvulus 0.0072 0.0051 0.081
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0094 0.0071 0.1653
Onchocerca volvulus 0.0072 0.0051 0.081
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0028 0.001 0.0012
Brugia malayi CUB domain containing protein 0.0026 0.0008 0.0008
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.011 0.0086 0.0086
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0013 0.0278
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0282 0.0245 0.371
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0061 0.0041 0.0931
Plasmodium vivax aspartyl protease, putative 0.0038 0.0019 0.0417
Schistosoma mansoni protein kinase 0.0127 0.0101 0.0101
Plasmodium vivax aspartyl proteinase, putative 0.0038 0.0019 0.0417
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0025 0.0025
Schistosoma mansoni glutamate receptor kainate 0.0031 0.0012 0.0012
Brugia malayi Glycosyl hydrolases family 31 protein 0.0041 0.0022 0.0022
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0088 0.0066 0.0066
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0037 0.0037
Echinococcus multilocularis discoidin domain receptor 0.0044 0.0025 0.0031
Brugia malayi hypothetical protein 0.0147 0.012 0.012
Onchocerca volvulus 0.0029 0.0011 0.017
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0126 0.01 0.2334
Loa Loa (eye worm) DEAH box polypeptide 35 0.0033 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.0035 0.0016 0.0016
Echinococcus granulosus c4b binding protein beta chain 0.0034 0.0016 0.0016
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0082 0.006 0.1379
Brugia malayi AMP-binding enzyme family protein 0.0094 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0094 0.0071 0.0071
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0084 0.0062 0.0062
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0502 0.0448 0.6779
Loa Loa (eye worm) hypothetical protein 0.0618 0.0556 0.0556
Brugia malayi Pepsin A precursor 0.0038 0.0019 0.0019
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0019 0.0002 0.0008
Echinococcus granulosus adam 17 protease 0.0019 0.0002 0.0002
Echinococcus multilocularis tissue type plasminogen activator 0.0031 0.0013 0.0016
Brugia malayi BmSERPIN, truncated 0.0023 0.0006 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.2153 0.1976 0.3235
Loa Loa (eye worm) hypothetical protein 0.0035 0.0016 0.0016
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0147 0.012 0.1815
Mycobacterium ulcerans fatty-acid-CoA ligase 0.007 0.0049 0.1132
Echinococcus granulosus integrin alpha ps 0.0135 0.0109 0.0109
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0028 0.0622
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0028 0.0028
Loa Loa (eye worm) glutamate receptor 1 0.0031 0.0012 0.0012
Loa Loa (eye worm) serpin 0.0023 0.0006 0.0005
Mycobacterium ulcerans acyl-CoA synthetase 0.0094 0.0071 0.1653
Entamoeba histolytica acyl-CoA synthetase, putative 0.0094 0.0071 0.1073
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0476 0.0424 0.0693
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.0096 0.2233
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0025 0.0038
Echinococcus multilocularis musashi 0.0028 0.001 0.0012
Entamoeba histolytica SWIRM domain protein 0.0052 0.0032 0.0485
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0502 0.0448 0.6779
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.0245 0.04
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.001 0.0197
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0019 0.0019
Onchocerca volvulus Sodium\/hydrogen exchanger homolog 0.01 0.0076 0.1213
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.0096 0.2233
Loa Loa (eye worm) CUB domain-containing protein 0.0026 0.0008 0.0008
Brugia malayi angiogenesis inhibito 0.0027 0.0009 0.0009
Entamoeba histolytica serine protease inhibitor, putative 0.0023 0.0006 0.0078
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0001 0.0001
Loa Loa (eye worm) transcriptional regulator 0.0731 0.066 0.066
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0013 0.0017
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0053 0.0033 0.0033
Brugia malayi Probable ATP-dependent helicase DHX35 0.0033 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.0053 0.0033 0.0033
Brugia malayi aspartic protease BmAsp-1, identical 0.0038 0.0019 0.0019
Echinococcus multilocularis cubilin 0.0026 0.0008 0.001
Loa Loa (eye worm) hypothetical protein 0.007 0.0049 0.0049
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0298 0.026 0.026
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.0245 0.04
Onchocerca volvulus 0.0026 0.0008 0.0125
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0108 0.0084 0.0135
Brugia malayi Pre-SET motif family protein 0.0611 0.055 0.0549
Onchocerca volvulus 0.0035 0.0016 0.0256
Schistosoma mansoni apoptosis regulator bax 0.0053 0.0033 0.0033
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.011 0.0086 0.0086
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.007 0.0049 0.4775
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0126 0.01 0.2334
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0476 0.0424 0.053
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.0069 0.0069
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0731 0.066 1
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0053 0.0033 0.0052
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0031 0.0012 0.0015
Brugia malayi Subtilase family protein 0.0476 0.0424 0.0424
Giardia lamblia Neurogenic locus Notch protein precursor 0.0049 0.003 0.0077
Onchocerca volvulus 0.0034 0.0016 0.0252
Loa Loa (eye worm) serpin 0.0023 0.0006 0.0005
Echinococcus multilocularis Estrogen regulated protein EP45 0.0023 0.0006 0.0007
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.0046 0.1048
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0476 0.0424 0.0693
Onchocerca volvulus 0.0026 0.0008 0.0125
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0038 0.0019 0.0417
Giardia lamblia Kinase, PLK 0.0092 0.0069 0.0185
Brugia malayi Serpin protein 6 0.0023 0.0006 0.0005
Brugia malayi AMP-binding enzyme family protein 0.0102 0.0078 0.0078
Echinococcus granulosus fibrillin 1 0.0052 0.0032 0.0032
Brugia malayi Sushi domain 0.0034 0.0016 0.0016
Schistosoma mansoni site-1 peptidase (S08 family) 0.0476 0.0424 0.0424
Entamoeba histolytica arginine N-methyltransferase 1, putative 0.0053 0.0033 0.0496
Echinococcus granulosus protein arginine N methyltransferase 7 0.0053 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0027 0.0009 0.0009
Schistosoma mansoni discoidin domain receptor 0.0044 0.0025 0.0025
Giardia lamblia Tenascin-X 0.0049 0.003 0.0077
Brugia malayi Pre-SET motif family protein 0.0088 0.0066 0.0066
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0094 0.0071 0.0089
Loa Loa (eye worm) latrophilin receptor protein 2 0.0094 0.0071 0.0071
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0053 0.0033 0.0041
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0036 0.0017 0.0365
Schistosoma mansoni protein kinase 0.0127 0.0101 0.0101
Brugia malayi serpin 0.0023 0.0006 0.0005
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0127 0.0101 0.0101
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0066 0.0045 0.1035
Echinococcus granulosus dna polymerase eta 0.0019 0.0001 0.0001
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0094 0.0071 0.1653
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0069 0.0112
Loa Loa (eye worm) hypothetical protein 0.007 0.0049 0.0049
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0476 0.0424 0.0693
Echinococcus granulosus integrin alpha ps 0.0065 0.0044 0.0044
Loa Loa (eye worm) proprotein convertase 2 0.2629 0.2416 0.2416
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0001 0.0002
Leishmania major hypothetical protein, conserved 0.0031 0.0013 0.0172
Echinococcus granulosus protein will die slowly 0.0152 0.0125 0.0125
Trichomonas vaginalis alpha-glucosidase, putative 0.0109 0.0085 0.0138
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0046 0.0027 0.0034
Plasmodium vivax glutathione reductase, putative 0.0047 0.0028 0.0622
Echinococcus granulosus serine protease inhibitor 0.0023 0.0006 0.0006
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0046 0.0027 0.0027
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0102 0.0078 0.0078
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0011 0.0011
Entamoeba histolytica SWIRM domain protein 0.0052 0.0032 0.0485
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.0096 0.2233
Schistosoma mansoni hypothetical protein 0.0094 0.0071 0.0071
Toxoplasma gondii propionate-CoA ligase 0.0028 0.001 0.019
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0019 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0008 0.0008
Onchocerca volvulus 0.0023 0.0006 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0025 0.0038
Loa Loa (eye worm) hypothetical protein 0.0043 0.0024 0.0024
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.023 0.0197 0.0196
Echinococcus granulosus GA binding protein alpha chain 0.0071 0.005 0.005
Brugia malayi hypothetical protein 0.0026 0.0008 0.0008
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0072 0.0072
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0001 0.0001
Brugia malayi serpin 0.0023 0.0006 0.0005
Echinococcus granulosus collagen alpha 1VII chain 0.002 0.0003 0.0003
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0476 0.0424 0.0693
Echinococcus multilocularis adam 0.0109 0.0085 0.0106
Brugia malayi Disintegrin family protein 0.0019 0.0002 0.0001
Loa Loa (eye worm) glutaminase 0.0264 0.0228 0.0228
Brugia malayi Nematode astacin protease protein 30 0.0026 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0026 0.0008 0.0008
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0015 0.0323
Brugia malayi CUB domain containing protein 0.0026 0.0008 0.0008
Plasmodium vivax subtilisin-like protease 1 0.0476 0.0424 1
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0094 0.0071 0.1645
Brugia malayi hypothetical protein 0.0034 0.0016 0.0016
Onchocerca volvulus 0.0034 0.0016 0.0252
Brugia malayi AMP-binding enzyme family protein 0.0028 0.001 0.0009
Schistosoma mansoni serine/threonine protein kinase 0.023 0.0197 0.0197
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0039 0.002 0.002
Entamoeba histolytica acyl-CoA synthetase, putative 0.0102 0.0079 0.1186
Trypanosoma cruzi arginine N-methyltransferase, type III 0.0053 0.0033 0.0482
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0019 0.0019
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0121 0.0096 0.0096
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0046 0.0027 0.0027
Brugia malayi Ets-domain containing protein 0.0071 0.005 0.005
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0108 0.0084 0.0105
Echinococcus granulosus neutral alpha glucosidase AB 0.0109 0.0085 0.0085
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0094 0.0071 0.0114
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.0084 0.1958
Schistosoma mansoni glutamate receptor AMPA 0.0031 0.0012 0.0012
Brugia malayi hypothetical protein 0.0126 0.01 0.01
Leishmania major subtilisin-like serine peptidase 0.0476 0.0424 0.6416
Loa Loa (eye worm) sodium/hydrogen exchanger 0.01 0.0076 0.0076
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2629 0.2416 0.3956
Echinococcus granulosus dna polymerase kappa 0.0019 0.0001 0.0001
Echinococcus multilocularis membrane bound transcription factor site 1 0.0476 0.0424 0.053
Brugia malayi sodium/hydrogen exchanger 3 family protein 0.0019 0.0002 0.0001
Plasmodium falciparum acyl-CoA synthetase 0.007 0.0049 0.1125
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0036 0.0017 0.0373
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0031 0.0013 0.0261
Entamoeba histolytica hypothetical protein, conserved 0.002 0.0003 0.0033
Plasmodium vivax hypothetical protein, conserved 0.0126 0.01 0.2334
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0031 0.0012 0.0012
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.002 0.0003 0.0002
Toxoplasma gondii PA14 domain-containing protein 0.0044 0.0025 0.0542
Loa Loa (eye worm) hypothetical protein 0.0026 0.0008 0.0008
Brugia malayi Lectin C-type domain containing protein 0.0026 0.0008 0.0008
Mycobacterium ulcerans Type I modular polyketide synthase 0.0077 0.0055 0.1271
Brugia malayi hypothetical protein 0.0019 0.0002 0.0001
Brugia malayi hypothetical protein 0.0038 0.0019 0.0019
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 0.01 0.0076 0.0076
Trypanosoma cruzi Na/H antiporter-like protein, putative 0.0019 0.0002 0.0005
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0109 0.0085 0.0106
Entamoeba histolytica sodium/proton antiporter, putative 0.0019 0.0002 0.0019
Loa Loa (eye worm) hypothetical protein 0.002 0.0003 0.0002
Trypanosoma brucei polo-like protein kinase 0.0092 0.0069 0.1033
Leishmania major arginine N-methyltransferase-like protein 0.0094 0.0071 0.1059
Plasmodium vivax plasmepsin IV, putative 0.0038 0.0019 0.0417
Schistosoma mansoni hypothetical protein 0.0152 0.0125 0.0125
Brugia malayi celfurPC protein 0.8674 0.8008 0.8008
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0028 0.001 0.0197
Onchocerca volvulus 0.0038 0.0019 0.0304
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.002 0.0003 0.0021
Loa Loa (eye worm) hypothetical protein 0.0049 0.003 0.003
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0069 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0025 0.0038
Plasmodium falciparum plasmepsin I 0.0038 0.0019 0.0417
Schistosoma mansoni glutamate receptor NMDA 0.0046 0.0027 0.0027
Echinococcus granulosus lamin dm0 0.0028 0.001 0.001
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0053 0.0033 0.0033
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0476 0.0424 0.0693
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0094 0.0071 0.1653
Chlamydia trachomatis glutamine binding protein 0.0078 0.0057 0.5528
Mycobacterium ulcerans ion antiporter, NhaP 0.0019 0.0002 0.0008
Loa Loa (eye worm) sodium/hydrogen exchanger 3 family protein 0.01 0.0076 0.0076
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.002 0.0003 0.0029
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0013 0.0017
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0013 0.0017
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0013 0.0278
Echinococcus multilocularis GPCR, family 2 0.0094 0.0071 0.0089
Trichomonas vaginalis conserved hypothetical protein 0.0476 0.0424 0.0693
Brugia malayi hypothetical protein 0.0034 0.0016 0.0016
Loa Loa (eye worm) subtilase 0.0476 0.0424 0.0424
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0094 0.0071 0.0089
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0069 0.0112
Schistosoma mansoni septate junction protein 0.0053 0.0033 0.0033
Trichomonas vaginalis sucrase-isomaltase, putative 0.0109 0.0085 0.0138
Brugia malayi SWIRM domain containing protein 0.067 0.0604 0.0604
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0045 0.0026 0.0581
Leishmania major alpha glucosidase II subunit, putative 0.0109 0.0085 0.1274
Loa Loa (eye worm) hypothetical protein 0.0147 0.012 0.012
Onchocerca volvulus Huntingtin homolog 0.0118 0.0094 0.1488
Echinococcus granulosus Furin 1 0.2629 0.2416 0.2416
Onchocerca volvulus 0.0044 0.0025 0.0388
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0019 0.0019
Onchocerca volvulus 0.0696 0.0628 1
Mycobacterium ulcerans polyketide synthase MbtD 0.0024 0.0007 0.0127
Onchocerca volvulus 0.0028 0.001 0.0151
Trichomonas vaginalis alpha-glucosidase, putative 0.0109 0.0085 0.0138
Giardia lamblia Fructose-bisphosphate aldolase 0.0282 0.0245 0.0664
Brugia malayi glutathione reductase 0.0047 0.0028 0.0028
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0031 0.0012 0.0012
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0001 0.0001
Brugia malayi Reprolysin 0.0027 0.0009 0.0009
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0025 0.0007 0.0129
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0102 0.0078 0.1823
Schistosoma mansoni hypothetical protein 0.0053 0.0033 0.0033
Schistosoma mansoni growth factor receptor-bound protein 0.0126 0.0101 0.0101
Loa Loa (eye worm) macrophage migration inhibitory factor 0.0173 0.0144 0.0144
Toxoplasma gondii subtilisin SUB5 0.0476 0.0424 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0036 0.0017 0.0373
Loa Loa (eye worm) hypothetical protein 0.0034 0.0016 0.0016
Toxoplasma gondii aspartyl protease ASP5 0.039 0.0345 0.8122
Plasmodium falciparum glutathione reductase 0.0047 0.0028 0.0622
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.002 0.0003 0.0021
Loa Loa (eye worm) fli-1 protein 0.0216 0.0184 0.0184
Onchocerca volvulus 0.0034 0.0016 0.0252
Loa Loa (eye worm) hypothetical protein 0.0034 0.0016 0.0016
Brugia malayi serpin 0.0023 0.0006 0.0005
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0126 0.0101 0.01
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0045 0.0045
Toxoplasma gondii subtilisin SUB7 0.0476 0.0424 1
Brugia malayi pregnancy-associated plasma protein-A 0.0034 0.0016 0.0016
Toxoplasma gondii SWIRM domain-containing protein 0.0052 0.0032 0.0729
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0034 0.0016 0.0016
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.0069 0.1103
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0013 0.0013
Onchocerca volvulus 0.0152 0.0125 0.1986
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.0046 0.1048
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0476 0.0424 1
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0013 0.0172
Giardia lamblia Tenascin-37 0.0049 0.003 0.0077
Schistosoma mansoni tyrosine kinase 0.0655 0.059 0.059
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0476 0.0424 1
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.002 0.0003 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0476 0.0424 0.0693
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0095 0.0072 0.0072
Schistosoma mansoni serpin 0.0023 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0028 0.001 0.0009
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.0069 0.1045
Plasmodium vivax plasmepsin V, putative 0.0428 0.038 0.8955
Echinococcus multilocularis CUB 0.0026 0.0008 0.001
Leishmania major Na/H antiporter-like protein 0.0019 0.0002 0.0005
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.002 0.0003 0.0021
Brugia malayi serpin (BmSERPIN) 0.0023 0.0006 0.0005
Brugia malayi ADAMTS-like protease 0.0027 0.0009 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0025 0.0038
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0476 0.0424 0.0693
Echinococcus granulosus growth factor receptor bound protein 2 0.0126 0.0101 0.0101
Schistosoma mansoni Slc9a7 protein 0.0019 0.0002 0.0002
Echinococcus multilocularis protein arginine N methyltransferase 7 0.0053 0.0033 0.0041
Brugia malayi Augmenter of liver regeneration 0.0034 0.0015 0.0015
Loa Loa (eye worm) glutamate receptor 2 0.0031 0.0012 0.0012
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.01 0.0076 0.0095
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0621 0.0558 0.0558
Plasmodium falciparum plasmepsin X 0.0038 0.0019 0.0417
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.001 0.0197
Schistosoma mansoni glutamate receptor AMPA 0.0031 0.0012 0.0012
Echinococcus granulosus neuroendocrine convertase 2 0.6839 0.6311 0.6311
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0611 0.055 0.0549
Mycobacterium ulcerans polyketide synthase 0.0077 0.0055 0.1271
Plasmodium falciparum plasmepsin VIII, putative 0.0038 0.0019 0.0417
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0078 0.0057 0.2225
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0053 0.0033 0.0052
Toxoplasma gondii subtilisin SUB6 0.0476 0.0424 1
Plasmodium falciparum cysteine repeat modular protein 1 0.0031 0.0013 0.0261
Schistosoma mansoni btb and poz domain-containing protein 0.0044 0.0025 0.0025
Plasmodium falciparum protoporphyrinogen oxidase 0.0126 0.01 0.2334
Trypanosoma cruzi UDP-galactopyranose mutase 0.0126 0.01 0.1501
Brugia malayi amine oxidase, flavin-containing family protein 0.0178 0.0149 0.0148
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.0084 0.1958
Loa Loa (eye worm) hypothetical protein 0.0026 0.0008 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.2153 0.1976 0.3235
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0476 0.0424 1
Echinococcus granulosus sodium:hydrogen exchanger 2 (nhe2) 0.0081 0.0059 0.0059
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0034 0.0015 0.0015
Brugia malayi Integrin alpha pat-2 precursor 0.0301 0.0262 0.0262
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0019 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.067 0.0604 0.0604
Echinococcus granulosus serine protease inhibitor 0.0023 0.0006 0.0006
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0022 0.0034
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0017 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.2153 0.1976 0.3235
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0082 0.006 0.1379
Loa Loa (eye worm) hypothetical protein 0.0023 0.0006 0.0005
Schistosoma mansoni serine protease inhibitors serpins 0.0023 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0173 0.0144 0.0234
Echinococcus granulosus discoidin domain containing receptor 2 0.0044 0.0025 0.0025
Schistosoma mansoni memapsin-2 (A01 family) 0.0038 0.0019 0.0019
Echinococcus multilocularis integrin alpha ps 0.0135 0.0109 0.0136
Plasmodium falciparum apical sushi protein 0.0034 0.0016 0.0339
Echinococcus multilocularis lamin 0.0028 0.001 0.0012
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2629 0.2416 0.3956
Echinococcus multilocularis fibrillin 2 0.0049 0.003 0.0037
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0108 0.0084 0.1946
Toxoplasma gondii microneme protein MIC2 0.002 0.0003 0.0021
Loa Loa (eye worm) hypothetical protein 0.0034 0.0016 0.0016
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0476 0.0424 0.0693
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.0084 0.1958
Onchocerca volvulus 0.002 0.0003 0.0038
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0025 0.0025
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0044 0.0025 0.0031
Toxoplasma gondii aspartyl protease 0.0038 0.0019 0.0417
Loa Loa (eye worm) serpin 0.0023 0.0006 0.0005
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0258 0.0223 0.0278
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0016 0.0024
Trichomonas vaginalis hypothetical protein 0.0049 0.003 0.0047
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0013 0.0017
Schistosoma mansoni serine protease inhibitors serpins 0.0023 0.0006 0.0006
Trypanosoma cruzi sodium/hydrogen exchanger, putative 0.0019 0.0002 0.0005
Brugia malayi beta-lactamase family protein 0.0035 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0233 0.0199 0.0199
Onchocerca volvulus 0.0034 0.0016 0.0252
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0025 0.0038
Brugia malayi proprotein convertase 2 0.6839 0.6311 0.6311
Giardia lamblia High cysteine protein 0.0049 0.003 0.0077
Mycobacterium ulcerans monoamine oxidase 0.0126 0.01 0.234
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0038 0.0872
Onchocerca volvulus 0.0023 0.0006 0.0086
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0082 0.006 0.1379
Plasmodium vivax aspartyl protease, putative 0.0038 0.0019 0.0417
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0053 0.0033 0.0033
Onchocerca volvulus 0.0094 0.0071 0.1133
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0044 0.0025 0.0038
Brugia malayi Stress-activated protein kinase jnk-1 0.023 0.0197 0.0196
Mycobacterium ulcerans Type I modular polyketide synthase 0.0077 0.0055 0.1271
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.0245 0.04
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0016 0.0024
Loa Loa (eye worm) hypothetical protein 0.0044 0.0025 0.0024
Echinococcus multilocularis cpg binding protein 0.0031 0.0013 0.0016
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0019 0.0019
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0077 0.0055 0.1264
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.0084 0.1958
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0038 0.0019 0.0029
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.002 0.0003 0.0002
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.001 0.0197
Echinococcus granulosus fibrillin 2 0.0049 0.003 0.003
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0127 0.0102 0.2373
Loa Loa (eye worm) hypothetical protein 0.0118 0.0094 0.0093
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0109 0.0085 0.198
Toxoplasma gondii subtilisin SUB11 0.0476 0.0424 1
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0032 0.0014 0.0296
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0476 0.0424 0.6416
Plasmodium vivax LCCL domain-containing protein 0.0044 0.0025 0.0542
Trichomonas vaginalis conserved hypothetical protein 0.2153 0.1976 0.3235
Schistosoma mansoni aldehyde dehydrogenase 0.0121 0.0096 0.0096
Schistosoma mansoni hypothetical protein 0.2153 0.1976 0.1976
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0094 0.0071 0.0071
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0094 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0236 0.0203 0.0202
Schistosoma mansoni hypothetical protein 0.0026 0.0008 0.0008
Echinococcus multilocularis neutral alpha glucosidase AB 0.0109 0.0085 0.0107
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0052 0.0032 0.0714
Mycobacterium tuberculosis Conserved protein 0.0035 0.0016 0.0353
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0108 0.0084 0.1252
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0069 0.1033
Mycobacterium ulcerans acyl-CoA synthetase 0.0036 0.0017 0.0373
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0025 0.0038
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0024 0.0007 0.0127
Echinococcus granulosus discoidin domain receptor 0.0044 0.0025 0.0025
Schistosoma mansoni integrin alpha-ps 0.0135 0.0109 0.0109
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0025 0.0007 0.0131
Onchocerca volvulus 0.0026 0.0008 0.0125
Trichomonas vaginalis maltase-glucoamylase, putative 0.0109 0.0085 0.0138
Loa Loa (eye worm) integrin beta-2 0.1531 0.1401 0.1401
Loa Loa (eye worm) hypothetical protein 0.002 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0108 0.0084 0.0084
Trichomonas vaginalis set domain proteins, putative 0.0696 0.0628 0.1026
Brugia malayi Carm1-pending protein 0.0053 0.0033 0.0033
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0053 0.0033 0.0482
Onchocerca volvulus 0.002 0.0003 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0025 0.0038
Schistosoma mansoni alpha-glucosidase 0.0425 0.0377 0.0377
Echinococcus multilocularis integrin alpha 3 0.0231 0.0198 0.0247
Brugia malayi Glycosyl hydrolases family 31 protein 0.0109 0.0085 0.0085
Trypanosoma cruzi Na/H antiporter-like protein, putative 0.0019 0.0002 0.0005
Schistosoma mansoni hypothetical protein 0.0053 0.0033 0.0033
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0126 0.01 0.2334
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0108 0.0084 0.0135
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0148 0.0121 0.0121
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.3223 0.2965 0.3703
Trypanosoma brucei subtilisin peptidase 0.0476 0.0424 0.6416
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.001 0.0197
Trichomonas vaginalis conserved hypothetical protein 0.2153 0.1976 0.3235
Giardia lamblia Neurogenic locus notch-like protein 0.0049 0.003 0.0077
Schistosoma mansoni furin-1 (S08 family) 0.4685 0.4319 0.4319
Plasmodium falciparum subtilisin-like protease 3 0.0476 0.0424 1
Brugia malayi von Willebrand Factor 0.002 0.0003 0.0002
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0082 0.006 0.1372
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0028 0.001 0.0127
Trichomonas vaginalis alpha-glucosidase, putative 0.0109 0.0085 0.0138
Onchocerca volvulus Huntingtin homolog 0.0118 0.0094 0.1488
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0028 0.001 0.0197
Leishmania major UDP-galactopyranose mutase 0.0126 0.01 0.1501

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.019 uM In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibition ChEMBL. 12086486

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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