Detailed information for compound 103395

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 309.319 | Formula: C17H15N3O3
  • H donors: 3 H acceptors: 4 LogP: 1.84 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)c1cccnc1
  • InChi: 1S/C17H15N3O3/c21-16(11-4-3-7-18-9-11)20-15(17(22)23)8-12-10-19-14-6-2-1-5-13(12)14/h1-7,9-10,15,19H,8H2,(H,20,21)(H,22,23)/t15-/m0/s1
  • InChiKey: YODAEYKPWSBUPN-HNNXBMFYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0018 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0016 0.0019
Echinococcus multilocularis epidermal growth factor receptor 0.0656 0.0589 0.0735
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.007 0.0035 0.0823
Echinococcus multilocularis 0.8487 0.8004 1
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0127 0.0089 0.2136
Toxoplasma gondii hypothetical protein 0.0089 0.0053 0.1259
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0005 0.0003
Brugia malayi Protein arginine N-methyltransferase 0.007 0.0035 0.0035
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0083 0.0047 0.0778
Schistosoma mansoni growth factor receptor-bound protein 0.0128 0.0089 0.0088
Plasmodium vivax subtilisin-like protease 2, putative 0.0466 0.0409 1
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.6476 0.61 0.61
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0051 0.0016 0.0019
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0047 0.0013 0.0014
Loa Loa (eye worm) hypothetical protein 0.0051 0.0016 0.0016
Echinococcus granulosus chromatin regulatory protein sir2 0.0741 0.067 0.0668
Leishmania major subtilisin-like serine peptidase 0.0466 0.0409 0.59
Schistosoma mansoni chromatin regulatory protein sir2 0.0741 0.067 0.0668
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0063 0.0028 0.0411
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0016 0.0019
Loa Loa (eye worm) hypothetical protein 0.0466 0.0409 0.0409
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0005 0.0003
Toxoplasma gondii F5/8 type C domain-containing protein 0.0051 0.0016 0.0366
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0016 0.0019
Loa Loa (eye worm) hypothetical protein 0.0089 0.0053 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0466 0.0409 0.0664
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.009 0.0053 0.0052
Entamoeba histolytica PH domain containing protein kinase, putative 0.0078 0.0043 0.0371
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0109 0.0072 0.0146
Echinococcus granulosus discoidin domain containing receptor 2 0.0051 0.0016 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0466 0.0409 0.0664
Echinococcus granulosus epidermal growth factor receptor 0.0656 0.0589 0.0588
Echinococcus granulosus Furin 1 0.2574 0.2406 0.2404
Echinococcus multilocularis integrin alpha 3 0.0687 0.0618 0.0771
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0109 0.0072 0.082
Onchocerca volvulus 0.0095 0.0059 0.0937
Loa Loa (eye worm) hypothetical protein 0.0678 0.061 0.061
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0059 0.0058
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.6476 0.61 0.7621
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0125 0.0087 0.0107
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0466 0.0409 0.051
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0633 0.0568 0.0568
Schistosoma mansoni hypothetical protein 0.007 0.0035 0.0034
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0466 0.0409 0.0664
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0466 0.0409 1
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0127 0.0089 0.2136
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0109 0.0072 0.0088
Toxoplasma gondii subtilisin SUB12 0.0466 0.0409 1
Echinococcus granulosus c-Jun N-terminal kinases 0.0232 0.0188 0.0187
Giardia lamblia High cysteine protein 0.0089 0.0053 0.0095
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0109 0.0072 0.007
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.2108 0.1964 0.3215
Schistosoma mansoni tyrosine kinase 0.0656 0.0589 0.0588
Mycobacterium ulcerans oxidoreductase 0.0127 0.0089 0.1843
Schistosoma mansoni protein kinase 0.0128 0.009 0.0088
Loa Loa (eye worm) hypothetical protein 0.0035 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0328 0.0279 0.0279
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0047 0.0013 0.0011
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0466 0.0409 0.0664
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0109 0.0072 0.011
Plasmodium vivax plasmepsin V, putative 0.043 0.0375 0.9167
Brugia malayi hypothetical protein 0.0477 0.042 0.042
Plasmodium falciparum plasmepsin IV 0.0038 0.0005 0.0075
Schistosoma mansoni amine oxidase 0.0127 0.0089 0.0087
Loa Loa (eye worm) hypothetical protein 0.0037 0.0004 0.0004
Loa Loa (eye worm) TK/EGFR protein kinase 0.0656 0.0589 0.0589
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0466 0.0409 0.0664
Schistosoma mansoni chromatin regulatory protein sir2 0.0109 0.0072 0.007
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0466 0.0409 0.0664
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0466 0.0409 0.59
Plasmodium vivax NAD-dependent deacetylase, putative 0.0109 0.0072 0.1724
Loa Loa (eye worm) hypothetical protein 0.0035 0.0001 0.0001
Plasmodium vivax LCCL domain-containing protein 0.0051 0.0016 0.0366
Onchocerca volvulus 0.0051 0.0016 0.0245
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0051 0.0016 0.0015
Loa Loa (eye worm) hypothetical protein 0.018 0.0139 0.0139
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0016 0.0019
Loa Loa (eye worm) hypothetical protein 0.4119 0.3868 0.3868
Brugia malayi Disintegrin family protein 0.0037 0.0004 0.0004
Plasmodium falciparum subtilisin-like protease 2 0.0466 0.0409 1
Brugia malayi hypothetical protein 0.0035 0.0001 0.0001
Toxoplasma gondii PA14 domain-containing protein 0.0051 0.0016 0.0366
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.0051 0.0016 0.0118
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0079 0.0044 0.5
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0741 0.067 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2574 0.2406 0.3939
Loa Loa (eye worm) hypothetical protein 0.0036 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0116 0.0078 0.0078
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0118 0.008 0.1709
Brugia malayi pregnancy-associated plasma protein-A 0.0035 0.0001 0.0001
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0053 0.0018 0.0021
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0005 0.0003
Brugia malayi Carm1-pending protein 0.007 0.0035 0.0035
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0127 0.0089 0.2136
Plasmodium vivax aspartyl protease, putative 0.0038 0.0005 0.0075
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2574 0.2406 0.3939
Loa Loa (eye worm) integrin alpha pat-2 0.128 0.118 0.118
Brugia malayi EGF-like domain containing protein 0.0089 0.0053 0.0053
Mycobacterium ulcerans Type I modular polyketide synthase 0.0078 0.0042 0.0657
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0054 0.002 0.0023
Brugia malayi Angiotensin-converting enzyme family protein 0.063 0.0565 0.0565
Onchocerca volvulus 0.0177 0.0136 0.2211
Brugia malayi EGF-like domain containing protein 0.0089 0.0053 0.0053
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0466 0.0409 0.0664
Brugia malayi angiogenesis inhibito 0.0052 0.0018 0.0018
Brugia malayi Stress-activated protein kinase jnk-1 0.0232 0.0188 0.0188
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0109 0.0072 0.0579
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0466 0.0409 0.0408
Toxoplasma gondii aspartyl protease ASP3 0.0038 0.0005 0.0075
Echinococcus granulosus growth factor receptor bound protein 2 0.0128 0.0089 0.0088
Schistosoma mansoni cathepsin D (A01 family) 0.0038 0.0005 0.0003
Brugia malayi celfurPC protein 0.8487 0.8004 0.8004
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 1.0595 1 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0128 0.009 0.0088
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0067 0.0032 0.0402
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0052 0.0018 0.0016
Echinococcus granulosus membrane bound transcription factor site 1 0.0466 0.0409 0.0408
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0741 0.067 0.1091
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0466 0.0409 1
Mycobacterium ulcerans Sir2-like regulatory protein 0.0109 0.0072 0.1415
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.009 0.0053 0.0052
Loa Loa (eye worm) hypothetical protein 0.0038 0.0005 0.0005
Echinococcus granulosus methyltransferase protein 5 0.007 0.0035 0.0034
Onchocerca volvulus 0.0036 0.0002 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.2108 0.1964 0.3215
Echinococcus multilocularis protein arginine N methyltransferase 7 0.007 0.0035 0.0042
Mycobacterium leprae PROBABLE CONSERVED TRANSMEMBRANE PROTEIN 0.0051 0.0016 0.0007
Echinococcus granulosus serine:threonine protein kinase N2 0.0078 0.0043 0.0041
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0062 0.0027 0.0278
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0741 0.067 0.1091
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0117 0.0079 0.0078
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0466 0.0409 0.0664
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2574 0.2406 0.3939
Plasmodium falciparum plasmepsin VIII, putative 0.0038 0.0005 0.0075
Toxoplasma gondii subtilisin SUB5 0.0466 0.0409 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2574 0.2406 0.3939
Giardia lamblia Tenascin precursor 0.0089 0.0053 0.0095
Echinococcus granulosus fibrillin 1 0.0092 0.0055 0.0054
Onchocerca volvulus 0.0051 0.0016 0.0245
Schistosoma mansoni chromatin regulatory protein sir2 0.0741 0.067 0.0668
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0496 0.0438 0.6349
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0109 0.0072 0.011
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0016 0.0019
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.007 0.0035 0.0823
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0109 0.0072 0.011
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0038 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0095 0.0059 0.0059
Plasmodium vivax plasmepsin IV, putative 0.0038 0.0005 0.0075
Loa Loa (eye worm) hypothetical protein 0.0095 0.0059 0.0059
Schistosoma mansoni growth factor receptor-bound protein 0.0128 0.0089 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0016 0.0019
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0051 0.0016 0.0019
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0112 0.0074 0.0074
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0196 0.0154 0.1867
Plasmodium falciparum plasmepsin I 0.0038 0.0005 0.0075
Brugia malayi Protein kinase domain containing protein 0.0051 0.0016 0.0016
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0047 0.0013 0.0014
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0047 0.0013 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0016 0.0019
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0047 0.0013 0.0014
Echinococcus granulosus protein arginine N methyltransferase 8 0.0125 0.0087 0.0085
Mycobacterium leprae Polyketide synthase Pks13 0.0118 0.008 0.1617
Loa Loa (eye worm) hypothetical protein 0.0089 0.0053 0.0053
Schistosoma mansoni hypothetical protein 0.0095 0.0059 0.0057
Echinococcus granulosus protein kinase c epsilon type 0.0096 0.0059 0.0058
Onchocerca volvulus 0.0038 0.0005 0.005
Giardia lamblia Tenascin-37 0.0089 0.0053 0.0095
Brugia malayi EGF-like domain containing protein 0.0089 0.0053 0.0053
Echinococcus multilocularis integrin beta 2 0.2311 0.2157 0.2694
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0078 0.0042 0.0761
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0109 0.0072 0.0088
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0044 0.001 0.0008
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.2108 0.1964 0.3215
Schistosoma mansoni dihydroceramide desaturase 0.0037 0.0004 0.0002
Trichomonas vaginalis WD repeat domain, putative 0.015 0.0111 0.0174
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0018
Schistosoma mansoni hypothetical protein 0.0052 0.0018 0.0016
Toxoplasma gondii subtilisin SUB4 0.0466 0.0409 1
Loa Loa (eye worm) hypothetical protein 0.0625 0.056 0.056
Plasmodium vivax subtilisin-like protease 1 0.0466 0.0409 1
Loa Loa (eye worm) hypothetical protein 0.0625 0.056 0.056
Echinococcus multilocularis chromatin regulatory protein sir2 0.0741 0.067 0.0835
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0083 0.0047 0.0778
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0038 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0038 0.0005 0.0005
Echinococcus granulosus discoidin domain receptor 0.0051 0.0016 0.0015
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0089 0.0053 0.0079
Loa Loa (eye worm) hypothetical protein 0.0089 0.0053 0.0053
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0036 0.0002 0.0002
Schistosoma mansoni integrin beta subunit 0.1835 0.1706 0.1705
Giardia lamblia Tenascin-like 0.0089 0.0053 0.0095
Loa Loa (eye worm) hypothetical protein 1.0595 1 1
Echinococcus granulosus integrin alpha 3 0.0687 0.0618 0.0617
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0037 0.0004 0.0003
Onchocerca volvulus 0.0075 0.004 0.0627
Onchocerca volvulus Deterin homolog 0.0052 0.0018 0.0269
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0125 0.0087 0.0085
Plasmodium vivax hypothetical protein, conserved 0.0127 0.0089 0.2136
Toxoplasma gondii subtilisin SUB6 0.0466 0.0409 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0133 0.0094 0.0094
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.6476 0.61 1
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0128 0.0089 0.0089
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0078 0.0042 0.0761
Schistosoma mansoni discoidin domain receptor 0.0051 0.0016 0.0015
Toxoplasma gondii histone deacetylase SIR2-like 0.0109 0.0072 0.1724
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0078 0.0042 0.0657
Leishmania major UDP-galactopyranose mutase 0.0127 0.0089 0.0844
Trichomonas vaginalis conserved hypothetical protein 0.2108 0.1964 0.3215
Loa Loa (eye worm) hypothetical protein 0.0051 0.0016 0.0016
Schistosoma mansoni furin-1 (S08 family) 0.4585 0.4309 0.4308
Loa Loa (eye worm) hypothetical protein 0.0061 0.0026 0.0026
Brugia malayi hypothetical protein 0.0127 0.0089 0.0089
Echinococcus granulosus inhibitor of apoptosis protein 0.0052 0.0018 0.0016
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0466 0.0409 0.0664
Loa Loa (eye worm) integrin beta-2 0.3124 0.2927 0.2927
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0096 0.0059 0.0059
Giardia lamblia Neurogenic locus Notch protein precursor 0.0089 0.0053 0.0095
Brugia malayi transcriptional regulator, Sir2 family protein 0.0109 0.0072 0.0072
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0109 0.0072 0.011
Plasmodium vivax aspartyl proteinase, putative 0.0038 0.0005 0.0075
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0044 0.001 0.0008
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0488 0.043 0.0429
Trichomonas vaginalis conserved hypothetical protein 0.0466 0.0409 0.0664
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0466 0.0409 1
Toxoplasma gondii subtilisin SUB9 0.0466 0.0409 1
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0016 0.0019
Loa Loa (eye worm) subtilase 0.0466 0.0409 0.0409
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0127 0.0089 0.2136
Loa Loa (eye worm) reprolysin 0.009 0.0053 0.0053
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0054 0.002 0.0018
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0109 0.0072 0.0579
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0466 0.0409 0.0409
Giardia lamblia Hypothetical protein 0.0741 0.067 0.1787
Mycobacterium tuberculosis Conserved hypothetical protein 0.0127 0.0089 0.1933
Onchocerca volvulus 0.015 0.0111 0.1792
Trichomonas vaginalis hypothetical protein 0.2108 0.1964 0.3215
Loa Loa (eye worm) hypothetical protein 0.0708 0.0639 0.0639
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0677 0.0609 0.0608
Plasmodium falciparum plasmepsin III 0.0038 0.0005 0.0075
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0466 0.0409 0.0664
Schistosoma mansoni septate junction protein 0.006 0.0025 0.0024
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0625 0.056 0.0559
Echinococcus granulosus neuroendocrine convertase 2 0.6693 0.6305 0.6305
Giardia lamblia High cysteine membrane protein Group 2 0.3902 0.3663 1
Loa Loa (eye worm) hypothetical protein 0.0633 0.0568 0.0568
Trypanosoma cruzi subtilisin peptidase 0.0466 0.0409 0.59
Trichomonas vaginalis conserved hypothetical protein 0.2108 0.1964 0.3215
Schistosoma mansoni site-1 peptidase (S08 family) 0.0466 0.0409 0.0408
Giardia lamblia Neurogenic locus notch-like protein 0.0089 0.0053 0.0095
Brugia malayi transcriptional regulator, Sir2 family protein 0.0109 0.0072 0.0072
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0466 0.0409 0.0664
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0005 0.0003
Echinococcus multilocularis protoporphyrinogen oxidase 0.0127 0.0089 0.0109
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0109 0.0072 0.011
Brugia malayi Will die slowly protein 0.015 0.0111 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.2108 0.1964 0.3215
Echinococcus granulosus nmda type glutamate receptor 0.011 0.0073 0.0071
Plasmodium falciparum LCCL domain-containing protein 0.0051 0.0016 0.0366
Toxoplasma gondii aspartyl protease ASP5 0.0392 0.0339 0.828
Loa Loa (eye worm) hypothetical protein 0.009 0.0053 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.2108 0.1964 0.3215
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0047 0.0013 0.0011
Loa Loa (eye worm) acyl carrier protein 0.0037 0.0003 0.0003
Toxoplasma gondii type I fatty acid synthase, putative 0.0083 0.0047 0.1109
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0041 0.0007 0.0133
Loa Loa (eye worm) endoprotease bli-4 1.0595 1 1
Schistosoma mansoni inhibitor of apoptosis protein 0.0052 0.0018 0.0016
Brugia malayi SWIRM domain containing protein 0.0678 0.061 0.061
Schistosoma mansoni integrin alpha-ps 0.0328 0.0279 0.0278
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0078 0.0042 0.0761
Echinococcus multilocularis protein jagged 2 0.0089 0.0053 0.0064
Trypanosoma brucei subtilisin peptidase 0.0466 0.0409 0.59
Loa Loa (eye worm) hypothetical protein 0.0089 0.0053 0.0053
Brugia malayi Sex muscle abnormal protein 5 0.0128 0.0089 0.0089
Leishmania major sir2-family protein-like protein 0.0109 0.0072 0.0579
Mycobacterium ulcerans polyketide synthase Pks13 0.0118 0.008 0.1617
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0466 0.0409 0.0664
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0127 0.0089 0.1843
Plasmodium falciparum plasmepsin VI 0.0038 0.0005 0.0075
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0052 0.0018 0.0018
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.2574 0.2406 0.2404
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0125 0.0087 0.0135
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0127 0.0089 0.1843
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0052 0.0018 0.0016
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0232 0.0188 0.0188
Toxoplasma gondii type I fatty acid synthase, putative 0.0057 0.0023 0.0519
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0466 0.0409 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0005 0.0005
Loa Loa (eye worm) WD40 repeat protein 0.015 0.0111 0.0111
Brugia malayi hypothetical protein 0.0035 0.0001 0.0001
Brugia malayi hypothetical protein 0.0035 0.0001 0.0001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2574 0.2406 0.3939
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0109 0.0072 0.011
Schistosoma mansoni hypothetical protein 0.0051 0.0016 0.0015
Brugia malayi proprotein convertase 2 0.6693 0.6305 0.6305
Onchocerca volvulus Fatty acid synthase homolog 0.0145 0.0106 0.1715
Echinococcus multilocularis protein arginine methyltransferase 0.0125 0.0087 0.0107
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0051 0.0016 0.0019
Schistosoma mansoni hypothetical protein 0.0246 0.0201 0.02
Plasmodium falciparum plasmepsin II 0.0038 0.0005 0.0075
Loa Loa (eye worm) transcriptional regulator 0.0109 0.0072 0.0072
Plasmodium falciparum plasmepsin IX 0.0038 0.0005 0.0075
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0466 0.0409 0.0664
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0125 0.0087 0.2092
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0079 0.0044 0.5
Echinococcus multilocularis protein kinase c epsilon type 0.0096 0.0059 0.0072
Onchocerca volvulus Putative cubilin 0.0039 0.0005 0.0064
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0466 0.0409 0.0664
Echinococcus granulosus integrin beta 2 0.2311 0.2157 0.2156
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0075 0.004 0.0702
Brugia malayi Reprolysin 0.0053 0.0018 0.0018
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0466 0.0409 0.0664
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0466 0.0409 0.0664
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0109 0.0072 0.011
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0035 0.0001 0.0001
Loa Loa (eye worm) transcriptional regulator 0.0109 0.0072 0.0072
Brugia malayi amine oxidase, flavin-containing family protein 0.018 0.0139 0.0139
Brugia malayi AMP-binding enzyme family protein 0.0075 0.004 0.004
Mycobacterium ulcerans dehydrogenase 0.0127 0.0089 0.1843
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0075 0.004 0.004
Brugia malayi hypothetical protein 0.0035 0.0001 0.0001
Brugia malayi Kelch motif family protein 0.0507 0.0448 0.0448
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0083 0.0047 0.0778
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0035 0.0001 0.0001
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0109 0.0072 0.0579
Echinococcus multilocularis serine:threonine protein kinase N2 0.0088 0.0051 0.0062
Mycobacterium leprae Probable polyketide synthase Pks1 0.0083 0.0047 0.0778
Echinococcus multilocularis fibrillin 1 0.0092 0.0055 0.0067
Loa Loa (eye worm) hypothetical protein 0.0035 0.0001 0.0001
Echinococcus granulosus disintegrin and metalloproteinase 0.0037 0.0004 0.0002
Toxoplasma gondii bicoid-interacting protein BIN3 0.007 0.0035 0.0823
Echinococcus multilocularis nmda type glutamate receptor 0.011 0.0073 0.0089
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0047 0.0013 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0466 0.0409 0.0664
Toxoplasma gondii aspartyl protease 0.0038 0.0005 0.0075
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0466 0.0409 0.0409
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2574 0.2406 0.3939
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0232 0.0188 0.0234
Schistosoma mansoni integrin alpha-ps 0.0513 0.0454 0.0452
Toxoplasma gondii subtilisin SUB7 0.0466 0.0409 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0078 0.0042 0.0657
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0109 0.0072 0.007
Echinococcus granulosus protein arginine N methyltransferase 7 0.007 0.0035 0.0034
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0466 0.0409 0.0664
Trichomonas vaginalis conserved hypothetical protein 0.2108 0.1964 0.3215
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0005 0.0003
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0496 0.0438 0.6349
Schistosoma mansoni protein kinase 0.0128 0.009 0.0088
Toxoplasma gondii subtilisin SUB10 0.0466 0.0409 1
Onchocerca volvulus 0.0678 0.061 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0001 0.0001
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0125 0.0087 0.0135
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.2108 0.1964 0.3215
Schistosoma mansoni integrin alpha 0.0954 0.0871 0.087
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0083 0.0047 0.088
Toxoplasma gondii subtilisin SUB2 0.0466 0.0409 1
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0127 0.0089 0.1843
Brugia malayi Calcium binding EGF domain containing protein 0.0039 0.0005 0.0005
Schistosoma mansoni apoptosis regulator bax 0.0054 0.002 0.0018
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0109 0.0072 0.0579
Brugia malayi Integrin alpha pat-2 precursor 0.0954 0.0871 0.0871
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0079 0.0044 0.0696
Mycobacterium ulcerans polyketide synthase 0.0083 0.0047 0.0778
Toxoplasma gondii histone deacetylase SIR2 0.0109 0.0072 0.1724
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0052 0.0018 0.0018
Brugia malayi Furin-like cysteine rich region family protein 0.0656 0.0589 0.0589
Entamoeba histolytica hypothetical protein, conserved 0.0109 0.0072 0.082
Chlamydia trachomatis protoporphyrinogen oxidase 0.0127 0.0089 1
Mycobacterium ulcerans NAD-dependent deacetylase 0.0109 0.0072 0.1415
Echinococcus granulosus fibrillin 2 0.0089 0.0053 0.0051
Plasmodium falciparum plasmepsin X 0.0038 0.0005 0.0075
Schistosoma mansoni chromatin regulatory protein sir2 0.0109 0.0072 0.007
Echinococcus multilocularis discoidin domain containing receptor 2 0.0051 0.0016 0.0019
Echinococcus granulosus adam 0.0207 0.0164 0.0163
Mycobacterium ulcerans monoamine oxidase 0.0127 0.0089 0.1843
Schistosoma mansoni protein arginine n-methyltransferase 0.007 0.0035 0.0034
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0466 0.0409 0.0664
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0109 0.0072 0.1724
Schistosoma mansoni glutamate receptor NMDA 0.0261 0.0216 0.0214
Schistosoma mansoni hypothetical protein 0.0054 0.002 0.0018
Loa Loa (eye worm) protein arginine N-methyltransferase 0.007 0.0035 0.0035
Plasmodium vivax hypothetical protein, conserved 0.0127 0.0089 0.2136
Schistosoma mansoni hypothetical protein 0.0095 0.0059 0.0057
Schistosoma mansoni memapsin-2 (A01 family) 0.0038 0.0005 0.0003
Entamoeba histolytica arginine N-methyltransferase 1, putative 0.007 0.0035 0.0256
Loa Loa (eye worm) fatty acid synthase 0.008 0.0044 0.0044
Schistosoma mansoni SWI/SNF complex-related 0.0053 0.0018 0.0017
Plasmodium falciparum protoporphyrinogen oxidase 0.0127 0.0089 0.2136
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0078 0.0042 0.0657
Schistosoma mansoni amine oxidase 0.0127 0.0089 0.0087
Echinococcus multilocularis discoidin domain containing receptor 2 0.0051 0.0016 0.0019
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0466 0.0409 0.0664
Brugia malayi hypothetical protein 0.0035 0.0001 0.0001
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0677 0.0609 0.0759
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0062 0.0027 0.0278
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0741 0.067 1
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0466 0.0409 1
Mycobacterium tuberculosis Probable thioesterase TesA 0.0067 0.0032 0.0508
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0005 0.0003
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0125 0.0087 0.0085
Echinococcus granulosus lysine specific histone demethylase 1A 0.0127 0.0089 0.0087
Loa Loa (eye worm) proprotein convertase 2 0.2574 0.2406 0.2406
Schistosoma mansoni hypothetical protein 0.0054 0.002 0.0018
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0083 0.0047 0.088
Giardia lamblia Transcriptional regulator, Sir2 family 0.0109 0.0072 0.0146
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.2108 0.1964 0.3215
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0058 0.0023 0.0287
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0016 0.0019
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0466 0.0409 0.0664
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0466 0.0409 1
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0125 0.0087 0.2092
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0741 0.067 1
Schistosoma mansoni site-1 peptidase (S08 family) 0.0466 0.0409 0.0408
Brugia malayi Pepsin A precursor 0.0038 0.0005 0.0005
Echinococcus granulosus histone arginine methyltransferase CARMER 0.007 0.0035 0.0034
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.015 0.011 0.011
Echinococcus granulosus subfamily M12B unassigned peptidase 0.009 0.0053 0.0052
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0741 0.067 0.0835
Brugia malayi Sushi domain 0.0035 0.0001 0.0001
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0125 0.0087 0.0135
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0127 0.0089 0.2136
Plasmodium falciparum plasmepsin VII 0.0038 0.0005 0.0075
Giardia lamblia High cysteine protein 0.0089 0.0053 0.0095
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0128 0.009 0.011
Onchocerca volvulus 0.0095 0.0059 0.0937
Giardia lamblia Sirtuin type 2 0.0109 0.0072 0.0146
Trichomonas vaginalis hypothetical protein 0.0051 0.0016 0.0019
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.007 0.0035 0.005
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0078 0.0042 0.0769
Schistosoma mansoni dock 0.0051 0.0016 0.0015
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.007 0.0035 0.005
Brugia malayi neuroendocrine convertase 1 precursor 0.6693 0.6305 0.6305
Brugia malayi aspartic protease BmAsp-2, identical 0.0038 0.0005 0.0005
Echinococcus multilocularis MAM 0.0095 0.0059 0.0071
Loa Loa (eye worm) sirtuin 4 0.0109 0.0072 0.0072
Echinococcus multilocularis membrane bound transcription factor site 1 0.0466 0.0409 0.051
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0062 0.0027 0.0278
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0125 0.0087 0.0085
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0466 0.0409 1
Brugia malayi hypothetical protein 0.0035 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0042 0.0008 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0016 0.0019
Onchocerca volvulus 0.0038 0.0005 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0466 0.0409 0.0664
Toxoplasma gondii aspartyl protease ASP1 0.0038 0.0005 0.0075
Brugia malayi hypothetical protein 0.0196 0.0154 0.0154
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0054 0.002 0.002
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0196 0.0154 0.1867
Mycobacterium leprae Possible secreted protease 0.0466 0.0409 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0005 0.0005
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0127 0.0089 0.0087
Brugia malayi Integrin beta pat-3 precursor 0.3124 0.2927 0.2927
Loa Loa (eye worm) aspartyl protease 6 0.0038 0.0005 0.0005
Brugia malayi hypothetical protein 0.0095 0.0059 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.2108 0.1964 0.3215
Plasmodium vivax aspartyl protease, putative 0.0038 0.0005 0.0075
Echinococcus multilocularis glutamate receptor 2 0.0047 0.0013 0.0014
Plasmodium vivax hypothetical protein, conserved 0.0109 0.0072 0.1724
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0466 0.0409 0.0664
Loa Loa (eye worm) hypothetical protein 0.0441 0.0386 0.0386
Mycobacterium tuberculosis Possible oxidoreductase 0.0127 0.0089 0.1933
Brugia malayi protein kinase C II. 0.0096 0.0059 0.0059
Brugia malayi hypothetical protein 0.0035 0.0001 0.0001
Giardia lamblia hypothetical protein 0.0089 0.0053 0.0095
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0109 0.0072 0.011
Mycobacterium ulcerans polyketide synthase 0.0078 0.0042 0.0657
Plasmodium vivax aspartyl protease, putative 0.0038 0.0005 0.0075
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0625 0.056 0.0698
Echinococcus granulosus MAM 0.0095 0.0059 0.0057
Onchocerca volvulus 0.014 0.0101 0.1637
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0109 0.0072 0.082
Echinococcus granulosus glutamate receptor 2 0.0047 0.0013 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0018 0.0023
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0051 0.0016 0.0019
Echinococcus multilocularis inhibitor of apoptosis protein 0.0052 0.0018 0.002
Loa Loa (eye worm) hypothetical protein 0.0044 0.001 0.001
Echinococcus multilocularis integrin alpha ps 0.0574 0.0512 0.0638
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.007 0.0035 0.0042
Schistosoma mansoni btb and poz domain-containing protein 0.0051 0.0016 0.0015
Schistosoma mansoni chromatin regulatory protein sir2 0.0741 0.067 0.0668
Echinococcus granulosus protein arginine methyltransferase 0.0125 0.0087 0.0085
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0037 0.0004 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.2108 0.1964 0.3215
Entamoeba histolytica hypothetical protein 0.0196 0.0154 0.2075
Echinococcus granulosus furin 1.0595 1 1
Schistosoma mansoni protein kinase 0.0128 0.009 0.0088
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0109 0.0072 0.1511
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0125 0.0087 0.2092
Giardia lamblia Furin precursor putative serine protease 0.2108 0.1964 0.534
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0118 0.008 0.1709
Trichomonas vaginalis conserved hypothetical protein 0.2108 0.1964 0.3215
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.6476 0.61 1
Brugia malayi NAD-dependent deacetylase SIRT1 0.0109 0.0072 0.0072
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0074 0.0038 0.0037
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0741 0.067 1
Echinococcus granulosus discoidin domain containing receptor 2 0.0051 0.0016 0.0015
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0038 0.0005 0.0075
Onchocerca volvulus 0.0052 0.0018 0.0269
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0466 0.0409 0.0408
Loa Loa (eye worm) apoptosis regulator protein 0.0054 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0109 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0054 0.002 0.002
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0078 0.0042 0.0769
Schistosoma mansoni hypothetical protein 0.0054 0.002 0.0018
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0196 0.0154 0.2075
Echinococcus multilocularis integrin alpha ps 0.0513 0.0454 0.0565
Brugia malayi SWIRM domain containing protein 0.0053 0.0018 0.0018
Giardia lamblia Tenascin-X 0.0089 0.0053 0.0095
Echinococcus multilocularis disintegrin and metalloproteinase 0.0037 0.0004 0.0003
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0196 0.0154 0.1867
Echinococcus granulosus glutamate NMDA receptor subunit 0.0261 0.0216 0.0214
Leishmania major silent information regulator 2, putative 0.0741 0.067 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.011 0.0073 0.0089
Echinococcus multilocularis discoidin domain containing receptor 2 0.0051 0.0016 0.0019
Toxoplasma gondii subtilisin SUB8 0.0466 0.0409 1
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0112 0.0074 0.0074
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0038 0.0005 0.0075
Brugia malayi aspartic protease BmAsp-1, identical 0.0038 0.0005 0.0005
Plasmodium vivax LCCL domain-containing protein 0.0051 0.0016 0.0366
Toxoplasma gondii F5/8 type C domain-containing protein 0.0051 0.0016 0.0366
Echinococcus granulosus lysine specific histone demethylase 1A 0.0625 0.056 0.0559
Schistosoma mansoni glutamate receptor NMDA 0.0047 0.0013 0.0011
Echinococcus multilocularis growth factor receptor bound protein 2 0.0128 0.0089 0.011
Mycobacterium ulcerans Type I modular polyketide synthase 0.0078 0.0042 0.0657
Echinococcus multilocularis neuroendocrine convertase 2 0.6693 0.6305 0.7878
Brugia malayi Protein kinase domain containing protein 0.0095 0.0059 0.0059
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0047 0.0013 0.0011
Schistosoma mansoni chromatin regulatory protein sir2 0.0109 0.0072 0.007
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0496 0.0438 0.6349
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0018
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0109 0.0072 0.0088
Echinococcus granulosus adam 17 protease 0.0037 0.0004 0.0002
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0466 0.0409 1
Trichomonas vaginalis hypothetical protein 0.0089 0.0053 0.0079
Echinococcus granulosus integrin alpha ps 0.0246 0.0201 0.02
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0741 0.067 0.0668
Loa Loa (eye worm) transcriptional regulator 0.0741 0.067 0.067
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0466 0.0409 0.0664
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0038 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0018
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0005 0.0003
Brugia malayi Subtilase family protein 0.0466 0.0409 0.0409
Brugia malayi transcriptional regulator, Sir2 family protein 0.0741 0.067 0.067
Loa Loa (eye worm) Carm1-pending protein 0.007 0.0035 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0016 0.0019
Plasmodium falciparum subtilisin-like protease 3 0.0466 0.0409 1
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0078 0.0042 0.0042
Brugia malayi hypothetical protein 0.0038 0.0005 0.0005
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0052 0.0018 0.0401
Brugia malayi ADAM-TS Spacer 1 family protein 0.0052 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0127 0.0089 0.0089
Toxoplasma gondii SWIRM domain-containing protein 0.0053 0.0018 0.0415
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0016 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0016 0.0019
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0466 0.0409 0.0664
Schistosoma mansoni chromatin regulatory protein sir2 0.0109 0.0072 0.007
Plasmodium vivax aspartyl proteinase, putative 0.0038 0.0005 0.0075
Loa Loa (eye worm) hypothetical protein 0.0127 0.0089 0.0089
Echinococcus multilocularis 0.0127 0.0089 0.0109
Echinococcus granulosus protein will die slowly 0.015 0.0111 0.0109
Echinococcus granulosus integrin alpha ps 0.0574 0.0512 0.051
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0053 0.0018 0.0017
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.009 0.0053 0.0065
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0466 0.0409 0.0664
Echinococcus multilocularis Furin 1 0.2574 0.2406 0.3004
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.007 0.0035 0.005
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0261 0.0216 0.0268
Loa Loa (eye worm) hypothetical protein 0.0053 0.0018 0.0018
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0741 0.067 1
Plasmodium vivax subtilisin-like serine protease, putative 0.0466 0.0409 1
Toxoplasma gondii histone lysine-specific demethylase 0.0127 0.0089 0.2136
Onchocerca volvulus 0.0089 0.0053 0.0844
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0083 0.0047 0.0778
Mycobacterium ulcerans thioesterase TesA 0.0067 0.0032 0.0402
Echinococcus multilocularis discoidin domain receptor 0.0051 0.0016 0.0019
Echinococcus multilocularis adam 0.0207 0.0164 0.0203
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0507 0.0448 0.0448
Toxoplasma gondii subtilisin SUB1 0.0466 0.0409 1
Schistosoma mansoni discoidin domain receptor 0.0051 0.0016 0.0015
Plasmodium falciparum LCCL domain-containing protein 0.0051 0.0016 0.0366
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.2684 0.2509 0.2508
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0054 0.002 0.0018
Brugia malayi EGF-like domain containing protein 0.0089 0.0053 0.0053
Echinococcus multilocularis fibrillin 2 0.0089 0.0053 0.0064
Mycobacterium ulcerans Type I modular polyketide synthase 0.0078 0.0042 0.0657
Plasmodium falciparum plasmepsin V 0.043 0.0375 0.9167
Loa Loa (eye worm) hypothetical protein 0.0307 0.0259 0.0259
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0005 0.0003
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0109 0.0072 0.1724
Loa Loa (eye worm) hypothetical protein 0.0036 0.0002 0.0002
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0079 0.0044 0.0799
Schistosoma mansoni hypothetical protein 0.015 0.0111 0.0109
Brugia malayi GCC2 and GCC3 family protein 0.0044 0.001 0.001
Brugia malayi Eukaryotic aspartyl protease family protein 0.0038 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.2108 0.1964 0.1963
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0466 0.0409 0.0664
Echinococcus multilocularis protein will die slowly 0.015 0.0111 0.0136
Schistosoma mansoni cathepsin D (A01 family) 0.0038 0.0005 0.0003
Toxoplasma gondii subtilisin SUB11 0.0466 0.0409 1
Echinococcus multilocularis integrin alpha ps 0.0246 0.0201 0.0249
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0083 0.0047 0.088
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0016 0.0019
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0466 0.0409 1
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0127 0.0089 0.1843
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0466 0.0409 0.0408
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0052 0.0018 0.002
Trypanosoma cruzi UDP-galactopyranose mutase 0.0127 0.0089 0.0844
Brugia malayi hypothetical protein 0.0038 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0196 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0477 0.042 0.042
Echinococcus granulosus discoidin domain containing receptor 2 0.0051 0.0016 0.0015
Plasmodium falciparum subtilisin-like protease 1 0.0466 0.0409 1
Trypanosoma cruzi UDP-galactopyranose mutase 0.0127 0.0089 0.0844
Loa Loa (eye worm) hypothetical protein 0.0035 0.0001 0.0001
Schistosoma mansoni serine/threonine protein kinase 0.0232 0.0188 0.0187
Trypanosoma brucei SIR2-like protein 4, putative 0.0109 0.0072 0.0579
Loa Loa (eye worm) hypothetical protein 0.0035 0.0001 0.0001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0466 0.0409 0.0664
Brugia malayi hypothetical protein 0.0117 0.0079 0.0079
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0038 0.0005 0.0005
Toxoplasma gondii F5/8 type C domain-containing protein 0.0051 0.0016 0.0366
Loa Loa (eye worm) TK/ALK protein kinase 0.0095 0.0059 0.0059
Brugia malayi ADAMTS-like protease 0.0052 0.0018 0.0018
Onchocerca volvulus 0.0466 0.0409 0.6702
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0109 0.0072 0.011
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0051 0.0016 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.2108 0.1964 0.3215
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0109 0.0072 0.007
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.063 0.0565 0.0565
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0016 0.0019
Mycobacterium ulcerans thioesterase 0.0067 0.0032 0.0402
Leishmania major arginine N-methyltransferase-like protein 0.0125 0.0087 0.0815

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 112 uM Inhibitory activity against association of LFA-1 with intercellular adhesion molecule 1 ChEMBL. 15080978
IC50 (binding) = 112 uM Inhibitory activity against association of LFA-1 with intercellular adhesion molecule 1 ChEMBL. 15080978

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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