TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 408.207 | Formula: C15H14BrN5O4
H donors: 3 H acceptors: 7 LogP: 1.76 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: [O-][N+](=O)c1cc(CNCc2ccncc2)c2c(c1)nc(c(n2)O)O.Br
InChi: 1S/C15H13N5O4.BrH/c21-14-15(22)19-13-10(5-11(20(23)24)6-12(13)18-14)8-17-7-9-1-3-16-4-2-9;/h1-6,17H,7-8H2,(H,18,21)(H,19,22);1H
InChiKey: GEGUXSHKCJJKOU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Glutamate receptor ionotropic, AMPA	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	Glutamate receptor ionotropic, AMPA	907 aa	809 aa	33.6 %
Onchocerca volvulus		Glutamate receptor ionotropic, AMPA	907 aa	796 aa	40.5 %
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	Glutamate receptor ionotropic, AMPA	907 aa	779 aa	33.4 %
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	Glutamate receptor ionotropic, AMPA	907 aa	948 aa	30.6 %
Drosophila melanogaster	Glutamate receptor IIB	Glutamate receptor ionotropic, AMPA	907 aa	863 aa	27.8 %
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	Glutamate receptor ionotropic, AMPA	907 aa	779 aa	33.4 %
Echinococcus multilocularis	glutamate receptor 2	Glutamate receptor ionotropic, AMPA	907 aa	868 aa	30.4 %
Drosophila melanogaster	Glutamate receptor IA	Glutamate receptor ionotropic, AMPA	907 aa	900 aa	40.6 %
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	Glutamate receptor ionotropic, AMPA	907 aa	959 aa	30.9 %
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	Glutamate receptor ionotropic, AMPA	907 aa	888 aa	34.0 %
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	Glutamate receptor ionotropic, AMPA	907 aa	809 aa	34.1 %
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	Glutamate receptor ionotropic, AMPA	907 aa	886 aa	34.2 %
Onchocerca volvulus	Putative 39S ribosomal protein L45, mitochondrial	Glutamate receptor ionotropic, AMPA	907 aa	799 aa	37.7 %
Drosophila melanogaster	NMDA receptor 2	Glutamate receptor ionotropic, AMPA	907 aa	789 aa	22.1 %
Echinococcus granulosus	glutamate receptor 2	Glutamate receptor ionotropic, AMPA	907 aa	875 aa	30.4 %
Schistosoma mansoni	glutamate receptor kainate	Glutamate receptor ionotropic, AMPA	907 aa	753 aa	33.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	glutamate receptor 1	0.003	0.0247	0.0247
Brugia malayi	Importin beta-1 subunit	0.0031	0.0266	0.0327
Loa Loa (eye worm)	hypothetical protein	0.0272	0.8124	0.8124
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0036	0.0435	0.0435
Schistosoma mansoni	ATP-binding cassette transporter	0.003	0.0247	0.0247
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0036	0.0435	0.0435
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0274	0.8192	1
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.0052	0.0959	0.0962
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-12	0.0052	0.0959	0.0959
Schistosoma mansoni	intermediate filament proteins	0.0032	0.0307	0.0307
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.0052	0.0959	0.0962
Brugia malayi	RNA recognition motif domain containing protein	0.015	0.4155	0.5115
Echinococcus multilocularis	lamin	0.0032	0.0307	0.0307
Echinococcus multilocularis	geminin	0.0187	0.5371	0.5371
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0043	0.0658	0.0577
Loa Loa (eye worm)	TAR-binding protein	0.015	0.4155	0.4155
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0052	0.0959	0.0959
Brugia malayi	Glutamate receptor 2 precursor	0.003	0.0247	0.0305
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0036	0.0435	0.0435
Leishmania major	fk506-binding protein 1-like protein	0.0052	0.0959	1
Schistosoma mansoni	loxhd1	0.0023	0.0025	0.0025
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0052	0.0959	1
Onchocerca volvulus		0.0043	0.0658	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0658	0.6858
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0288	0.0288
Echinococcus multilocularis	tar DNA binding protein	0.015	0.4155	0.4155
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0272	0.8124	0.5
Schistosoma mansoni	glutamate receptor AMPA	0.003	0.0247	0.0247
Echinococcus granulosus	glutamate receptor 2	0.0036	0.0435	0.0435
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0075	0.0786
Trypanosoma brucei	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0052	0.0959	1
Echinococcus multilocularis	musashi	0.0032	0.0307	0.0307
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0094	0.2314	0.2848
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0066	0.1403	0.1403
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0051	0.0909	0.1119
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0178	0.507	0.507
Mycobacterium ulcerans	beta-lactamase	0.0043	0.0658	0.0582
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0658	0.0577
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP1A	0.0052	0.0959	0.0959
Echinococcus multilocularis	glutamate receptor 2	0.0036	0.0435	0.0435
Plasmodium falciparum	peptidyl-prolyl cis-trans isomerase FKBP35	0.0052	0.0959	0.118
Loa Loa (eye worm)	doublecortin family protein	0.0023	0.0025	0.0025
Loa Loa (eye worm)	RNA binding protein	0.015	0.4155	0.4155
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0909	0.0909
Brugia malayi	RNA, U transporter 1	0.0088	0.2121	0.261
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0043	0.0658	0.0577
Brugia malayi	beta-lactamase family protein	0.0043	0.0658	0.0809
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0052	0.0959	1
Trypanosoma brucei	importin beta-1 subunit, putative	0.0031	0.0266	0.277
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0658	0.6858
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0052	0.0959	1
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0658	0.0577
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.003	0.0247	0.0247
Schistosoma mansoni	hypothetical protein	0.0187	0.5371	0.5371
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0075	0.0786
Onchocerca volvulus		0.0043	0.0658	1
Schistosoma mansoni	rab6-interacting	0.0023	0.0025	0.0025
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0658	0.6858
Schistosoma mansoni	lipoxygenase	0.0066	0.1403	0.1403
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0036	0.0435	0.0435
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0272	0.8124	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0043	0.0658	0.0809
Plasmodium falciparum	LCCL domain-containing protein	0.0023	0.0025	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0025
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0023	0.0025	0.0025
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0272	0.8124	1
Loa Loa (eye worm)	intermediate filament protein	0.0032	0.0307	0.0307
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0909	0.0909
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0658	0.0658
Mycobacterium ulcerans	lipase LipD	0.0043	0.0658	0.0582
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0045	0.0725	0.0725
Mycobacterium tuberculosis	Probable lipase LipE	0.0043	0.0658	0.0577
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0658	0.0658
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0094	0.2314	0.267
Schistosoma mansoni	hypothetical protein	0.0023	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0725	0.0725
Brugia malayi	hypothetical protein	0.0023	0.0025	0.0031
Plasmodium vivax	multidomain scavenger receptor, putative	0.0023	0.0025	0.0031
Loa Loa (eye worm)	glutamate receptor 2	0.003	0.0247	0.0247
Onchocerca volvulus		0.0032	0.0307	0.4452
Mycobacterium ulcerans	hypothetical protein	0.0043	0.0658	0.0582
Schistosoma mansoni	tar DNA-binding protein	0.015	0.4155	0.4155
Toxoplasma gondii	hypothetical protein	0.0094	0.2314	0.2848
Echinococcus granulosus	intermediate filament protein	0.0032	0.0307	0.0307
Brugia malayi	beta-lactamase family protein	0.0043	0.0658	0.0809
Schistosoma mansoni	immunophilin FK506 binding protein FKBP12	0.0052	0.0959	0.0959
Echinococcus multilocularis	fk506 binding protein	0.0052	0.0959	0.0959
Trypanosoma brucei	importin beta-1 subunit, putative	0.0031	0.0266	0.277
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type , putative	0.0052	0.0959	1
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0272	0.8124	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0658	0.6858
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0272	0.8124	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0658	0.0658
Schistosoma mansoni	tar DNA-binding protein	0.015	0.4155	0.4155
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0307	0.0307
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0036	0.0435	0.0435
Schistosoma mansoni	glutamate receptor kainate	0.003	0.0247	0.0247
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0066	0.1403	0.1403
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0658	0.6858
Schistosoma mansoni	tar DNA-binding protein	0.015	0.4155	0.4155
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0909	0.0909
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0272	0.8124	1
Brugia malayi	RNA binding protein	0.015	0.4155	0.5115
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0043	0.0658	0.0577
Onchocerca volvulus		0.0032	0.0307	0.4452
Schistosoma mansoni	rab6-interacting	0.0023	0.0025	0.0025
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0052	0.0959	0.0959
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0178	0.507	0.6096
Loa Loa (eye worm)	FKBP5 protein	0.0052	0.0959	0.0959
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0658	0.0658
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0178	0.507	0.591
Schistosoma mansoni	glutamate receptor kainate	0.003	0.0247	0.0247
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0052	0.0959	1
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59	0.0052	0.0959	0.118
Echinococcus multilocularis	importin subunit beta 1	0.0031	0.0266	0.0266
Echinococcus multilocularis	lamin dm0	0.0032	0.0307	0.0307
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0272	0.8124	1
Schistosoma mansoni	glutamate receptor NMDA	0.0036	0.0435	0.0435
Leishmania major	hypothetical protein, conserved	0.0043	0.0658	0.6858
Giardia lamblia	70 kDa peptidylprolyl isomerase, putative	0.0052	0.0959	1
Mycobacterium tuberculosis	Probable hydrolase	0.0043	0.0658	0.0577
Plasmodium vivax	70 kDa peptidylprolyl isomerase, putative	0.0052	0.0959	0.118
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0043	0.0658	0.0658
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.0052	0.0959	1
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0094	0.2314	0.2848
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0658	0.0577
Schistosoma mansoni	glutamate receptor NMDA	0.003	0.0247	0.0247
Schistosoma mansoni	lamin	0.0032	0.0307	0.0307
Schistosoma mansoni	tar DNA-binding protein	0.015	0.4155	0.4155
Schistosoma mansoni	immunophilin	0.0045	0.0725	0.0725
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0658	0.0658
Leishmania major	peptidylprolyl isomerase-like protein	0.0052	0.0959	1
Echinococcus multilocularis	glutamate receptor 2	0.003	0.0247	0.0247
Echinococcus granulosus	lipoxygenase domain containing protein	0.0023	0.0025	0.0025
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12	0.0052	0.0959	0.118
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0272	0.8124	1
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0272	0.8124	0.8124
Echinococcus multilocularis	Polycystic kidney disease protein	0.0023	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0025	0.0025
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0658	0.6858
Schistosoma mansoni	lamin	0.0032	0.0307	0.0307
Schistosoma mansoni	lipoxygenase	0.0023	0.0025	0.0025
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0272	0.8124	0.8124
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0266	0.0266
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	0.0094	0.2314	0.2218
Schistosoma mansoni	polycystin 1-related	0.0023	0.0025	0.0025
Loa Loa (eye worm)	beta-lactamase	0.0043	0.0658	0.0658
Mycobacterium tuberculosis	Probable lipase LipD	0.0043	0.0658	0.0577
Schistosoma mansoni	peptidase Clp (S14 family)	0.0272	0.8124	0.8124
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0909	0.0909
Schistosoma mansoni	immunophilin	0.0052	0.0959	0.0959
Echinococcus granulosus	tar DNA binding protein	0.015	0.4155	0.4155
Trichomonas vaginalis	fk506-binding protein, putative	0.0052	0.0959	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0043	0.0658	0.0658
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0032	0.0307	0.0307
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type, putative	0.0052	0.0959	1
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0036	0.0435	0.0435
Schistosoma mansoni	importin beta-1	0.0031	0.0266	0.0266
Trichomonas vaginalis	importin beta-1, putative	0.0025	0.0075	0.0786
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0658	0.6858
Brugia malayi	Intermediate filament tail domain containing protein	0.0032	0.0307	0.0378
Brugia malayi	TAR-binding protein	0.015	0.4155	0.5115
Plasmodium falciparum	importin beta, putative	0.0031	0.0266	0.0327
Toxoplasma gondii	HEAT repeat-containing protein	0.0031	0.0266	0.0327
Echinococcus multilocularis	snurportin 1	0.0329	1	1
Trichomonas vaginalis	esterase, putative	0.0043	0.0658	0.6858
Mycobacterium tuberculosis	Probable esterase LipL	0.0043	0.0658	0.0577
Echinococcus multilocularis	glutamate receptor 2	0.0025	0.0069	0.0069
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0045	0.0725	0.0725
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0043	0.0658	0.0658
Schistosoma mansoni	hypothetical protein	0.0329	1	1
Giardia lamblia	FKBP-type peptidyl-prolyl cis-trans isomerase	0.0052	0.0959	1
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.0658	0.0809
Trypanosoma brucei	hypothetical protein, conserved	0.0043	0.0658	0.6858
Brugia malayi	intermediate filament protein	0.0032	0.0307	0.0378
Schistosoma mansoni	immunophilin	0.0052	0.0959	0.0959
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0909	0.0909
Echinococcus granulosus	glutamate NMDA receptor subunit	0.003	0.0247	0.0247
Brugia malayi	Doublecortin family protein	0.0023	0.0025	0.0031
Brugia malayi	beta-lactamase	0.0043	0.0658	0.0809
Brugia malayi	Probable ClpP-like protease	0.0272	0.8124	1
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0272	0.8124	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0909	0.0909
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.015	0.4155	0.4155
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0272	0.8124	1
Onchocerca volvulus		0.0043	0.0658	1
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0052	0.0959	1
Echinococcus multilocularis	nmda type glutamate receptor	0.004	0.0562	0.0562
Toxoplasma gondii	ABC1 family protein	0.0043	0.0658	0.0809
Schistosoma mansoni	glutamate receptor AMPA	0.003	0.0247	0.0247
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0025	0.0075	0.0786
Echinococcus granulosus	Polycystic kidney disease protein	0.0023	0.0025	0.0025
Echinococcus multilocularis	RUN	0.0023	0.0025	0.0025
Entamoeba histolytica	hypothetical protein	0.0025	0.0075	0.0786
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0052	0.0959	1
Brugia malayi	hypothetical protein	0.0023	0.0025	0.0031
Echinococcus granulosus	lamin dm0	0.0032	0.0307	0.0307
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0036	0.0435	0.0435
Echinococcus granulosus	peptidase Clp S14 family	0.0178	0.507	0.507
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0178	0.507	0.6096
Echinococcus granulosus	glutamate receptor 2	0.0025	0.0069	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0658	0.0658
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0272	0.8124	1
Leishmania major	importin beta-1 subunit, putative	0.0025	0.0075	0.0786
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0036	0.0435	0.0435
Schistosoma mansoni	tar DNA-binding protein	0.015	0.4155	0.4155
Brugia malayi	Glutamate receptor 1 precursor	0.003	0.0247	0.0305
Echinococcus granulosus	geminin	0.0187	0.5371	0.5371
Echinococcus granulosus	importin subunit beta 1	0.0031	0.0266	0.0266
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0909	0.0909
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.004	0.0562	0.0562
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0329	1	1
Trichomonas vaginalis	immunophilin, putative	0.0052	0.0959	1
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0043	0.0658	0.0582
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0051	0.0909	0.0909
Schistosoma mansoni	glutamate receptor kainate	0.003	0.0247	0.0247
Echinococcus granulosus	lamin	0.0032	0.0307	0.0307
Mycobacterium ulcerans	esterase/lipase LipP	0.0043	0.0658	0.0582
Plasmodium vivax	importin-beta 2, putative	0.0031	0.0266	0.0327
Echinococcus granulosus	nmda type glutamate receptor	0.004	0.0562	0.0562
Echinococcus granulosus	lipoxygenase domain containing protein	0.0023	0.0025	0.0025
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0023	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0658	0.0658
Schistosoma mansoni	hypothetical protein	0.0187	0.5371	0.5371
Echinococcus granulosus	RUN	0.0023	0.0025	0.0025
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0658	0.0658

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.4 uM	Tested for in vitro binding affinity against AMPA receptor using [3H]-AMPA binding assay	ChEMBL.	9871631
Inhibition (binding)	= 36 %	Inhibition of [3H]-MDL-105,519 binding to NMDA receptor glycine binding site	ChEMBL.	9871631

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL544655

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1034145