Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | thymidylate synthase | 1.0647 | 0.816 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.616 | 0.4698 | 0.5755 |
Chlamydia trachomatis | dihydrofolate reductase | 0.616 | 0.4698 | 0.5 |
Echinococcus multilocularis | folylpolyglutamate synthase, mitochondrial | 0.021 | 0.0106 | 0.0125 |
Echinococcus granulosus | selenide water dikinase | 0.0131 | 0.0045 | 0.0051 |
Plasmodium vivax | selenophosphate synthetase, putative | 0.0131 | 0.0045 | 0.0045 |
Schistosoma mansoni | selinide water dikinase | 0.0131 | 0.0045 | 0.0051 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 1.3032 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 1.0647 | 0.816 | 1 |
Mycobacterium tuberculosis | Probable phosphoribosylamine--glycine ligase PurD (GARS) (glycinamide ribonucleotide synthetase) (phosphoribosylglycinamide synt | 0.0256 | 0.0141 | 0.0169 |
Trypanosoma brucei | Selenophosphate synthetase 2 | 0.0131 | 0.0045 | 0.0041 |
Toxoplasma gondii | selenide, water dikinase | 0.0131 | 0.0045 | 0.0041 |
Trypanosoma brucei | folylpolyglutamate synthase, putative | 0.021 | 0.0106 | 0.0102 |
Brugia malayi | hypothetical protein | 0.5065 | 0.3852 | 0.4719 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.616 | 0.4698 | 0.5755 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 1.3032 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.616 | 0.4698 | 0.5755 |
Mycobacterium tuberculosis | Probable phosphoribosylformylglycinamidine CYCLO-ligase PurM (AIRS) (phosphoribosyl-aminoimidazole synthetase) (air synthase) | 0.0388 | 0.0243 | 0.0293 |
Echinococcus multilocularis | folylpolyglutamate synthase, mitochondrial | 0.021 | 0.0106 | 0.0125 |
Onchocerca volvulus | 0.0388 | 0.0243 | 0.017 | |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 1.0647 | 0.816 | 1 |
Treponema pallidum | folylpolyglutamate synthetase (folC) | 0.021 | 0.0106 | 0.5 |
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT | 0.1757 | 0.1299 | 0.1589 |
Leishmania major | folylpolyglutamate synthetase | 0.021 | 0.0106 | 0.0102 |
Echinococcus multilocularis | 0.0131 | 0.0045 | 0.0051 | |
Trypanosoma cruzi | selenophosphate synthetase, putative | 0.0131 | 0.0045 | 0.0041 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.616 | 0.4698 | 0.5755 |
Plasmodium falciparum | dihydrofolate synthase/folylpolyglutamate synthase | 0.021 | 0.0106 | 0.0106 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylformylglycinamidine synthase domain-containing protein | 0.0131 | 0.0045 | 0.0319 |
Mycobacterium ulcerans | phosphoribosylaminoimidazole synthetase | 0.0388 | 0.0243 | 0.0298 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.616 | 0.4698 | 0.5757 |
Echinococcus granulosus | dihydrofolate reductase | 0.616 | 0.4698 | 0.5755 |
Loa Loa (eye worm) | thymidylate synthase | 1.0647 | 0.816 | 1 |
Mycobacterium leprae | PROBABLE THIAMINE-MONOPHOSPHATE KINASE THIL (THIAMINE-PHOSPHATE KINASE) | 0.0079 | 0.0004 | 0.0001 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.5065 | 0.3852 | 0.385 |
Onchocerca volvulus | 1.0647 | 0.816 | 1 | |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.616 | 0.4698 | 0.5755 |
Trichomonas vaginalis | conserved hypothetical protein | 0.5065 | 0.3852 | 1 |
Plasmodium vivax | dihydrofolate synthase/folylpolyglutamate synthase, putative | 0.021 | 0.0106 | 0.0106 |
Brugia malayi | FolC bifunctional protein | 0.021 | 0.0106 | 0.0125 |
Mycobacterium ulcerans | phosphoribosylformylglycinamidine synthase II | 0.0131 | 0.0045 | 0.0055 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 1.0647 | 0.816 | 1 |
Trypanosoma cruzi | folylpolyglutamate synthase, putative | 0.021 | 0.0106 | 0.0102 |
Echinococcus granulosus | folylpolyglutamate synthase, mitochondrial | 0.021 | 0.0106 | 0.0125 |
Echinococcus granulosus | thymidylate synthase | 1.0647 | 0.816 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 1.3032 | 1 | 1 |
Schistosoma mansoni | folylpolyglutamate synthase | 0.021 | 0.0106 | 0.0125 |
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE PURM (AIRS) (PHOSPHORIBOSYL-AMINOIMIDAZOLE SYNTHETASE) (AIR SYNTHASE) | 0.0388 | 0.0243 | 0.0293 |
Trypanosoma cruzi | folylpolyglutamate synthetase | 0.021 | 0.0106 | 0.0102 |
Trypanosoma brucei | pteridine reductase 1 | 0.0211 | 0.0107 | 0.0103 |
Schistosoma mansoni | dihydrofolate reductase | 0.616 | 0.4698 | 0.5755 |
Toxoplasma gondii | bifunctional protein FolC subfamily protein | 0.021 | 0.0106 | 0.0102 |
Onchocerca volvulus | 0.0309 | 0.0182 | 0.0095 | |
Mycobacterium tuberculosis | Probable folylpolyglutamate synthase protein FolC (folylpoly-gamma-glutamate synthetase) (FPGS) | 0.021 | 0.0106 | 0.0125 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 1.3032 | 1 | 1 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0078 | 0.0004 | 0.0004 |
Echinococcus multilocularis | dihydrofolate reductase | 0.616 | 0.4698 | 0.5755 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.1757 | 0.1299 | 1 |
Leishmania major | pteridine reductase 1 | 0.0214 | 0.0109 | 0.0105 |
Leishmania major | selenophosphate synthetase, putative | 0.0131 | 0.0045 | 0.0041 |
Mycobacterium leprae | PROBABLE FOLYLPOLYGLUTAMATE SYNTHASE PROTEIN FOLC (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS) | 0.021 | 0.0106 | 0.0125 |
Mycobacterium ulcerans | thymidylate synthase | 1.0647 | 0.816 | 1 |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.1757 | 0.1299 | 0.1592 |
Mycobacterium tuberculosis | Phosphoribosylformylglycinamidine synthase II PurL (FGAM synthase II) | 0.0131 | 0.0045 | 0.0051 |
Plasmodium falciparum | selenide water dikinase, putative | 0.0131 | 0.0045 | 0.0045 |
Brugia malayi | selenium donor protein | 0.0131 | 0.0045 | 0.0051 |
Echinococcus granulosus | folylpolyglutamate synthase mitochondrial | 0.021 | 0.0106 | 0.0125 |
Mycobacterium tuberculosis | Hypothetical protein | 0.5065 | 0.3852 | 0.4719 |
Trypanosoma cruzi | selenophosphate synthetase, putative | 0.0131 | 0.0045 | 0.0041 |
Mycobacterium ulcerans | thiamine monophosphate kinase | 0.0079 | 0.0004 | 0.0005 |
Loa Loa (eye worm) | selenium donor protein | 0.0131 | 0.0045 | 0.0051 |
Loa Loa (eye worm) | FolC protein | 0.021 | 0.0106 | 0.0125 |
Mycobacterium leprae | PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE II PURL (FGAM SYNTHASE II) | 0.0131 | 0.0045 | 0.0051 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 1.0647 | 0.816 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 1.3032 | 1 | 1 |
Mycobacterium ulcerans | folylpolyglutamate synthase protein FolC | 0.021 | 0.0106 | 0.0129 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylaminoimidazole synthetase | 0.0388 | 0.0243 | 0.1846 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.