Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.136 | 0.0662 |
Schistosoma mansoni | acetylcholinesterase | 0.0406 | 0.136 | 0.136 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0092 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2404 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0092 | 0 | 0.5 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0406 | 0.136 | 0.136 |
Toxoplasma gondii | thioredoxin reductase | 0.0265 | 0.0748 | 1 |
Brugia malayi | glutathione reductase | 0.0265 | 0.0748 | 0.0748 |
Echinococcus granulosus | carboxylesterase 5A | 0.2404 | 1 | 1 |
Echinococcus granulosus | neuroligin | 0.0406 | 0.136 | 0.136 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0092 | 0 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0092 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0406 | 0.136 | 0.136 |
Loa Loa (eye worm) | carboxylesterase | 0.0406 | 0.136 | 0.0662 |
Leishmania major | trypanothione reductase | 0.0265 | 0.0748 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0406 | 0.136 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.2404 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.2404 | 1 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0406 | 0.136 | 0.136 |
Treponema pallidum | NADH oxidase | 0.0092 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.136 | 0.0662 |
Onchocerca volvulus | 0.0406 | 0.136 | 0.5 | |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0406 | 0.136 | 0.136 |
Loa Loa (eye worm) | carboxylesterase | 0.0406 | 0.136 | 0.0662 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0265 | 0.0748 | 0.0748 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0406 | 0.136 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.136 | 0.0662 |
Brugia malayi | Carboxylesterase family protein | 0.0406 | 0.136 | 0.136 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0406 | 0.136 | 0.136 |
Brugia malayi | Carboxylesterase family protein | 0.2404 | 1 | 1 |
Echinococcus multilocularis | neuroligin | 0.0406 | 0.136 | 0.136 |
Plasmodium falciparum | glutathione reductase | 0.0265 | 0.0748 | 1 |
Onchocerca volvulus | 0.0406 | 0.136 | 0.5 | |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0905 | 0.3519 | 0.3519 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0406 | 0.136 | 0.136 |
Schistosoma mansoni | gliotactin | 0.0406 | 0.136 | 0.136 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0406 | 0.136 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0265 | 0.0748 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.136 | 0.0662 |
Loa Loa (eye worm) | carboxylesterase | 0.2404 | 1 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0406 | 0.136 | 0.136 |
Brugia malayi | Carboxylesterase family protein | 0.0406 | 0.136 | 0.136 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0265 | 0.0748 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0265 | 0.0748 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0406 | 0.136 | 0.136 |
Brugia malayi | Carboxylesterase family protein | 0.0406 | 0.136 | 0.136 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0406 | 0.136 | 0.136 |
Loa Loa (eye worm) | hypothetical protein | 0.2404 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.2404 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2404 | 1 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0265 | 0.0748 | 0.5499 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0406 | 0.136 | 0.136 |
Loa Loa (eye worm) | hypothetical protein | 0.2404 | 1 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0092 | 0 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0265 | 0.0748 | 0.0748 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0406 | 0.136 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.136 | 0.0662 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0406 | 0.136 | 0.136 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0406 | 0.136 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2404 | 1 | 1 |
Onchocerca volvulus | 0.0406 | 0.136 | 0.5 | |
Onchocerca volvulus | 0.0406 | 0.136 | 0.5 | |
Brugia malayi | Thioredoxin reductase | 0.0265 | 0.0748 | 0.0748 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0406 | 0.136 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0265 | 0.0748 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0265 | 0.0748 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.2404 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0406 | 0.136 | 0.136 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.136 | 0.0662 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.136 | 0.0662 |
Onchocerca volvulus | 0.0406 | 0.136 | 0.5 | |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0406 | 0.136 | 0.136 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 20 uM l-1 | Cytotoxicity for relative cell viability compared to untreated control in Primary leukemic cells(PLC) by MTT assay | ChEMBL. | 12747777 |
IC50 (functional) | = 20 uM l-1 | Cytotoxicity for relative cell viability compared to untreated control in CEFcells by MTT assay | ChEMBL. | 12747777 |
Relative ODN uptake (functional) | = 3.2 | Relative uptake of ODN in Primary leukemic cells(PLC) incubated with 0.25 uMol/L of P32-labeled v-myb antisense ODN for 2 hr at a concentration of 2.5 uMol/L | ChEMBL. | 12747777 |
Relative ODN uptake (functional) | = 5.1 | Relative uptake of ODN in BM2 cells incubated with 0.25 uMol/L of P32-labeled v-myb antisense ODN for 2 hr at a concentration of 2.5 uMol/L | ChEMBL. | 12747777 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.