Detailed information for compound 1034636

Basic information

Technical information
  • TDR Targets ID: 1034636
  • Name: [4-[7-methoxy-3-methoxycarbonyl-1-oxo-4-(3,4, 5-trimethoxyphenyl)isoquinolin-2-yl]phenyl]az anium chloride
  • MW: 526.965 | Formula: C27H27ClN2O7
  • H donors: 1 H acceptors: 2 LogP: 4.32 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc2c(c1)c(=O)n(c(c2c1cc(OC)c(c(c1)OC)OC)C(=O)OC)c1ccc(cc1)N.Cl
  • InChi: 1S/C27H26N2O7.ClH/c1-32-18-10-11-19-20(14-18)26(30)29(17-8-6-16(28)7-9-17)24(27(31)36-5)23(19)15-12-21(33-2)25(35-4)22(13-15)34-3;/h6-14H,28H2,1-5H3;1H
  • InChiKey: YXTPROBOJLGFEB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [4-[7-methoxy-3-methoxycarbonyl-1-oxo-4-(3,4,5-trimethoxyphenyl)-2-isoquinolyl]phenyl]ammonium chloride
  • [4-[3-carbomethoxy-1-keto-7-methoxy-4-(3,4,5-trimethoxyphenyl)-2-isoquinolyl]phenyl]ammonium chloride

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Canis lupus famiaris Phosphodiesterase 5A Starlite/ChEMBL References
Homo sapiens phosphodiesterase 3B, cGMP-inhibited References
Homo sapiens phosphodiesterase 3A, cGMP-inhibited Starlite/ChEMBL References
Rattus norvegicus Phosphodiesterase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Trypanosoma cruzi cAMP phosphodiesterase A, putative Get druggable targets OG5_128202 All targets in OG5_128202
Leishmania infantum cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei gambiense 3, 5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Neospora caninum hypothetical protein Get druggable targets OG5_128202 All targets in OG5_128202
Trypanosoma brucei gambiense cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic Get druggable targets OG5_128202 All targets in OG5_128202
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132613 All targets in OG5_132613
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei cAMP phosphodiesterase A, putative Get druggable targets OG5_128202 All targets in OG5_128202
Schistosoma japonicum expressed protein Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative Get druggable targets OG5_127318 All targets in OG5_127318
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Cryptosporidium hominis cGMP phosphodiesterase A4 Get druggable targets OG5_128202 All targets in OG5_128202
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein Get druggable targets OG5_132613 All targets in OG5_132613
Neospora caninum hypothetical protein Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase Get druggable targets OG5_128202 All targets in OG5_128202
Candida albicans similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Loa Loa (eye worm) PDE1B protein Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania donovani cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma congolense cAMP-specific phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei cAMP-specific phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania braziliensis cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei gambiense cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania mexicana phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Trypanosoma congolense 3', 5'-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Trypanosoma brucei cAMP-specific phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Cryptosporidium parvum cGMP phosphodiesterase A4 Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative Get druggable targets OG5_128202 All targets in OG5_128202
Schistosoma japonicum Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania braziliensis cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Neospora caninum 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein Get druggable targets OG5_128202 All targets in OG5_128202
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic Get druggable targets OG5_128202 All targets in OG5_128202
Trypanosoma cruzi cAMP phosphodiesterase A, putative Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania donovani phosphodiesterase, putative Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania infantum cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic Get druggable targets OG5_128202 All targets in OG5_128202
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132613 All targets in OG5_132613
Leishmania mexicana cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Candida albicans similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania braziliensis cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 Get druggable targets OG5_128202 All targets in OG5_128202
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Toxoplasma gondii hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma congolense cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 Get druggable targets OG5_128202 All targets in OG5_128202
Leishmania infantum cAMP phosphodiesterase A Get druggable targets OG5_128202 All targets in OG5_128202
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania mexicana cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Phosphodiesterase 1   535 aa 463 aa 28.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.011 0.0646 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.011 0.0646 1
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0115 0.0694 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0717 0.672 0.672
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0115 0.0694 1
Mycobacterium tuberculosis Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) 0.0546 0.5008 0.5
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0115 0.0694 0.1033
Loa Loa (eye worm) hypothetical protein 0.0069 0.0235 0.0235
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.011 0.0646 0.0962
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.011 0.0646 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0266 0.221 0.221
Trichomonas vaginalis conserved hypothetical protein 0.011 0.0646 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.011 0.0646 1
Mycobacterium ulcerans isocitrate lyase Icl 0.0546 0.5008 0.5
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0115 0.0694 0.1033
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0069 0.0235 0.0235
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0045 0 0.5
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.011 0.0646 1
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0115 0.0694 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.011 0.0646 0.9306
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0115 0.0694 1
Giardia lamblia Hypothetical protein 0.0045 0 0.5
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0266 0.221 0.3288
Trypanosoma brucei cAMP-specific phosphodiesterase 0.011 0.0646 0.9306
Mycobacterium leprae PROBABLE ISOCITRATE LYASE AceA (ISOCITRASE) (ISOCITRATASE) (ICL) 0.0546 0.5008 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.011 0.0646 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0069 0.0235 0.0235
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0235 0.3632
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.011 0.0646 0.9306
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0069 0.0235 0.0349
Plasmodium falciparum phosphodiesterase delta, putative 0.0045 0 0.5
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.011 0.0646 1
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0115 0.0694 1
Loa Loa (eye worm) hypothetical protein 0.1045 1 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.011 0.0646 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.011 0.0646 1
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0717 0.672 1
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0193 0.2992
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0086 0.0412 0.6368
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0045 0 0.5
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.011 0.0646 1
Toxoplasma gondii hypothetical protein 0.0065 0.0193 0.2784
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.011 0.0646 0.0962
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0069 0.0235 0.3632
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0266 0.221 0.3288
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0069 0.0235 0.3632
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.011 0.0646 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.011 0.0646 1
Mycobacterium ulcerans isocitrate lyase AceAb 0.0546 0.5008 0.5
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.011 0.0646 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.011 0.0646 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.011 0.0646 1
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.011 0.0646 0.0962
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0717 0.672 0.672
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.011 0.0646 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.011 0.0646 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.011 0.0646 1
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0069 0.0235 0.0349
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.011 0.0646 1
Mycobacterium tuberculosis Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) 0.0546 0.5008 0.5
Loa Loa (eye worm) hypothetical protein 0.1 0.9547 0.9547
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0045 0 0.5
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.011 0.0646 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.011 0.0646 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0045 0 0.5
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0045 0 0.5
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.011 0.0646 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.011 0.0646 0.9306
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0266 0.221 0.3288
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.011 0.0646 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.011 0.0646 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0717 0.672 1
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0069 0.0235 0.0349
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0115 0.0694 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.011 0.0646 1
Plasmodium falciparum phosphodiesterase gamma, putative 0.0045 0 0.5
Giardia lamblia hypothetical protein 0.0045 0 0.5
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.011 0.0646 0.9306
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.011 0.0646 1
Mycobacterium tuberculosis Isocitrate lyase Icl (isocitrase) (isocitratase) 0.0546 0.5008 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0193 0.2992
Loa Loa (eye worm) PDE1B protein 0.0266 0.221 0.221
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0115 0.0694 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0717 0.672 1
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0193 0.2992
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.011 0.0646 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.011 0.0646 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0086 0.0412 0.6368
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0086 0.0412 0.5926

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 20 nM Inhibitory activity against canine lung Phosphodiesterase 5 (PDE5) ChEMBL. 11405657
IC50 (binding) = 1000 nM Inhibitory activity against rat heart Phosphodiesterase 1(PDE1) ChEMBL. 11405657
IC50 (binding) > 10000 nM Inhibitory activity against canine heart Phosphodiesterase 3 (PDE3) ChEMBL. 11405657

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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