Detailed information for compound 103469

Basic information

Technical information
  • TDR Targets ID: 103469
  • Name: N-[(4-chlorophenyl)methyl]-3-methoxynaphthale ne-2-carboxamide
  • MW: 325.789 | Formula: C19H16ClNO2
  • H donors: 1 H acceptors: 1 LogP: 4.54 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2ccccc2cc1C(=O)NCc1ccc(cc1)Cl
  • InChi: 1S/C19H16ClNO2/c1-23-18-11-15-5-3-2-4-14(15)10-17(18)19(22)21-12-13-6-8-16(20)9-7-13/h2-11H,12H2,1H3,(H,21,22)
  • InChiKey: VGOMFNBWNCJTJD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(4-chlorophenyl)methyl]-3-methoxy-naphthalene-2-carboxamide
  • N-[(4-chlorophenyl)methyl]-3-methoxy-2-naphthalenecarboxamide
  • N-(4-chlorobenzyl)-3-methoxy-2-naphthamide
  • AIDS-096812
  • AIDS096812
  • ZINC03598128
  • N-[(4-Chlorophenyl)methyl](3-methoxy(2-naphthyl))carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human Blymphotropic virus) Human herpesvirus 6 DNA polymerase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K02327 DNA polymerase delta subunit 1, putative Get druggable targets OG5_127429 All targets in OG5_127429
Leishmania major DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Plasmodium knowlesi DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Trypanosoma congolense DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Giardia lamblia DNA polymerase delta, catalytic subunit Get druggable targets OG5_127429 All targets in OG5_127429
Echinococcus multilocularis DNA polymerase delta catalytic subunit Get druggable targets OG5_127429 All targets in OG5_127429
Loa Loa (eye worm) DNA-directed DNA polymerase III Get druggable targets OG5_127429 All targets in OG5_127429
Neospora caninum DNA polymerase (EC 2.7.7.7), related Get druggable targets OG5_127429 All targets in OG5_127429
Onchocerca volvulus DNA polymerase delta catalytic subunit homolog Get druggable targets OG5_127429 All targets in OG5_127429
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Toxoplasma gondii DNA polymerase Get druggable targets OG5_127429 All targets in OG5_127429
Plasmodium berghei DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Echinococcus granulosus DNA polymerase delta catalytic subunit Get druggable targets OG5_127429 All targets in OG5_127429
Candida albicans N terminus of DNA-directed DNA polymerase III (delta) Get druggable targets OG5_127429 All targets in OG5_127429
Leishmania mexicana DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Candida albicans N terminus of DNA-directed DNA polymerase III (delta) Get druggable targets OG5_127429 All targets in OG5_127429
Brugia malayi DNA polymerase delta catalytic subunit Get druggable targets OG5_127429 All targets in OG5_127429
Cryptosporidium hominis DNA polymerase family B subunit Get druggable targets OG5_127429 All targets in OG5_127429
Plasmodium vivax DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Leishmania braziliensis DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Trypanosoma brucei gambiense DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Babesia bovis DNA polymerase delta subunit Get druggable targets OG5_127429 All targets in OG5_127429
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Candida albicans hypothetical protein Get druggable targets OG5_127429 All targets in OG5_127429
Plasmodium falciparum DNA polymerase delta catalytic subunit Get druggable targets OG5_127429 All targets in OG5_127429
Leishmania infantum DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Leishmania donovani DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Plasmodium yoelii DNA polymerase delta catalytic subunit Get druggable targets OG5_127429 All targets in OG5_127429
Cryptosporidium parvum DNA polymerase delta catalytic subunit. DNAQ-like 3-5 exonuclease; RNAseH fold Get druggable targets OG5_127429 All targets in OG5_127429
Schistosoma mansoni DNA polymerase delta catalytic subunit Get druggable targets OG5_127429 All targets in OG5_127429
Theileria parva DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative Get druggable targets OG5_127429 All targets in OG5_127429
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Human herpesvirus 6 DNA polymerase   1012 aa 931 aa 29.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Kinase, CMGC CDK 0.0087 0.0156 0.0412
Brugia malayi hypothetical protein 0.0073 0.0094 0.0066
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.0092 0.0179 0.0152
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0111 0.0262 0.5
Brugia malayi hypothetical protein 0.0073 0.0094 0.0066
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0262 0.0398
Trichomonas vaginalis conserved hypothetical protein 0.05 0.2011 0.3637
Toxoplasma gondii subtilisin SUB9 0.0111 0.0262 0.459
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0087 0.0156 0.0129
Trichomonas vaginalis CMGC family protein kinase 0.0087 0.0156 0.0203
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0094 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.009 0.008
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0111 0.0262 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0066
Brugia malayi Protein kinase domain containing protein 0.0132 0.0359 0.0332
Brugia malayi Cyclin, N-terminal domain containing protein 0.0063 0.0047 0.0019
Onchocerca volvulus Neuropeptide F receptor homolog 0.0073 0.0094 0.0568
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0111 0.0262 0.4703
Loa Loa (eye worm) G-protein coupled receptor 0.0073 0.0094 0.0066
Toxoplasma gondii kringle domain-containing protein 0.0132 0.0359 0.8817
Toxoplasma gondii DNA polymerase 0.0092 0.0179 0.0991
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0073 0.0094 0.0075
Brugia malayi Hypothetical WD-repeat protein F21H12.1 in chromosome II 0.0072 0.009 0.0062
Schistosoma mansoni biogenic amine receptor 0.0073 0.0094 0.0066
Loa Loa (eye worm) cyclin domain-containing protein 0.0063 0.0047 0.0019
Schistosoma mansoni cyclin B3 0.0063 0.0047 0.0019
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0066
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0111 0.0262 1
Echinococcus granulosus somatostatin receptor 0.0073 0.0094 0.0066
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.05 0.2011 0.3637
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0066
Echinococcus multilocularis cyclin B 0.015 0.044 0.0471
Brugia malayi Serotonin receptor 0.0073 0.0094 0.0066
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0094 0.0075
Echinococcus granulosus neuropeptide s receptor 0.0073 0.0094 0.0066
Echinococcus granulosus wd40 repeat 0.0072 0.009 0.0062
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0073 0.0094 0.0066
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0262 0.0398
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0062 0.0045 0.0017
Schistosoma mansoni biogenic amine receptor 0.0073 0.0094 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0262 0.0398
Echinococcus multilocularis neuropeptide FF receptor 2 0.0779 0.3261 0.3689
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.0094 0.0066
Brugia malayi DNA polymerase delta catalytic subunit 0.0092 0.0179 0.0152
Echinococcus granulosus G protein coupled receptor 139 0.0073 0.0094 0.0066
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0094 0.0075
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0066
Echinococcus multilocularis cyclin dependent kinase 0.0087 0.0156 0.0147
Echinococcus multilocularis G protein coupled receptor 139 0.0073 0.0094 0.0075
Brugia malayi Kringle domain containing protein 0.0132 0.0359 0.0332
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0073 0.0094 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0262 0.0398
Onchocerca volvulus 0.015 0.044 0.2672
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0094 0.0066
Brugia malayi hypothetical protein 0.0073 0.0094 0.0066
Brugia malayi follicle stimulating hormone receptor 0.0073 0.0094 0.0066
Echinococcus granulosus neuropeptides capa receptor 0.0073 0.0094 0.0066
Loa Loa (eye worm) hypothetical protein 0.0088 0.0159 0.0132
Echinococcus multilocularis cyclins 0.0063 0.0047 0.0022
Loa Loa (eye worm) TK/ROR protein kinase 0.0132 0.0359 0.0332
Echinococcus multilocularis membrane bound transcription factor site 1 0.0111 0.0262 0.0267
Brugia malayi Melatonin receptor type 1A 0.0073 0.0094 0.0066
Echinococcus multilocularis cyclins 0.0063 0.0047 0.0022
Echinococcus granulosus neuropeptide FF receptor 2 0.0779 0.3261 0.3242
Schistosoma mansoni hypothetical protein 0.0073 0.0094 0.0066
Schistosoma mansoni amine GPCR 0.0073 0.0094 0.0066
Schistosoma mansoni hypothetical protein 0.0073 0.0094 0.0066
Echinococcus multilocularis neuropeptides capa receptor 0.0073 0.0094 0.0075
Schistosoma mansoni hypothetical protein 0.0104 0.0231 0.0204
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.0092 0.0179 0.0152
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0087 0.0156 0.0129
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0092 0.0179 0.2248
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0066
Echinococcus granulosus cyclins 0.0063 0.0047 0.0019
Giardia lamblia G2/mitotic-specific cyclin B 0.015 0.044 0.148
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0262 0.0398
Schistosoma mansoni hypothetical protein 0.2012 0.8793 0.879
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0094 0.0066
Echinococcus multilocularis neuropeptide receptor 0.0073 0.0094 0.0075
Schistosoma mansoni cyclin B 0.015 0.044 0.0414
Echinococcus multilocularis orexin receptor type 2 0.0073 0.0094 0.0075
Brugia malayi AKH receptor 0.0073 0.0094 0.0066
Onchocerca volvulus 0.0068 0.007 0.0426
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0066
Plasmodium falciparum subtilisin-like protease 2 0.0111 0.0262 0.6887
Loa Loa (eye worm) hypothetical protein 0.0132 0.0359 0.0332
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0262 0.0398
Schistosoma mansoni opsin-like receptor 0.0073 0.0094 0.0066
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative 0.0092 0.0179 0.0802
Onchocerca volvulus 0.0419 0.1648 1
Brugia malayi Trypsin family protein 0.0419 0.1648 0.1625
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0262 0.0398
Loa Loa (eye worm) TK/EGFR protein kinase 0.0273 0.0993 0.0968
Brugia malayi Will die slowly protein 0.0068 0.007 0.0042
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0111 0.0262 0.0267
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.0094 0.0066
Schistosoma mansoni hypothetical protein 0.0073 0.0094 0.0066
Echinococcus granulosus cyclin dependent kinase 1 0.0087 0.0156 0.0129
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0073 0.0094 0.0075
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0094 0.0066
Trichomonas vaginalis cyclin B, putative 0.015 0.044 0.0729
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0132 0.0359 1
Echinococcus granulosus neuropeptide Y receptor 0.0073 0.0094 0.0066
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0066
Echinococcus multilocularis cyclin b3 0.0063 0.0047 0.0022
Echinococcus granulosus 7TM GPCR rhodopsin 0.0073 0.0094 0.0066
Onchocerca volvulus 0.0073 0.0094 0.0568
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0663 0.2741 0.4989
Loa Loa (eye worm) endoprotease bli-4 0.2281 1 1
Giardia lamblia Kinase, CMGC CDK 0.0087 0.0156 0.0412
Brugia malayi Furin-like cysteine rich region family protein 0.0273 0.0993 0.0968
Echinococcus multilocularis neuropeptide receptor 0.0073 0.0094 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.05 0.2011 0.3637
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0066
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0553 0.2245 0.4071
Echinococcus multilocularis cyclin dependent kinase 5 0.0087 0.0156 0.0147
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0066
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0163 0.0496 0.0831
Echinococcus multilocularis neuroendocrine convertase 2 0.1678 0.7294 0.829
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0073 0.0094 0.0066
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0066
Echinococcus multilocularis protein will die slowly 0.0068 0.007 0.0048
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0262 0.0398
Echinococcus multilocularis cyclins 0.0063 0.0047 0.0022
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0066
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0066
Schistosoma mansoni opsin-like receptor 0.0073 0.0094 0.0066
Echinococcus granulosus g protein coupled receptor 0.0073 0.0094 0.0066
Schistosoma mansoni amine GPCR 0.0073 0.0094 0.0066
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0066
Schistosoma mansoni opsin-like receptor 0.0073 0.0094 0.0066
Trichomonas vaginalis CMGC family protein kinase 0.0087 0.0156 0.0203
Plasmodium falciparum cysteine repeat modular protein 1 0.0132 0.0359 1
Echinococcus granulosus tm gpcr rhodopsin 0.0073 0.0094 0.0066
Echinococcus granulosus cyclins 0.0063 0.0047 0.0019
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0087 0.0156 0.0129
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0073 0.0094 0.0066
Schistosoma mansoni alpha-1 adrenergic receptor 0.0073 0.0094 0.0066
Loa Loa (eye worm) TYRA-2 protein 0.0073 0.0094 0.0066
Echinococcus granulosus peptide allatostatin:somatostatin 0.0073 0.0094 0.0066
Echinococcus multilocularis 0.178 0.7755 0.8815
Schistosoma mansoni myosin xvIII 0.0073 0.0094 0.0066
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0111 0.0262 0.5
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0073 0.0094 0.0066
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0094 0.0066
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0073 0.0094 0.0568
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0111 0.0262 0.5
Echinococcus granulosus neuropeptide Y receptor 0.0073 0.0094 0.0066
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0066
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0087 0.0156 0.0129
Brugia malayi Subtilase family protein 0.0111 0.0262 0.0235
Echinococcus granulosus cyclins 0.0063 0.0047 0.0019
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0114 0.0279 0.4317
Entamoeba histolytica cell division protein kinase 2, putative 0.0087 0.0156 0.2782
Loa Loa (eye worm) hypothetical protein 0.1067 0.4553 0.4538
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0094 0.0075
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0066
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0073 0.0094 0.0066
Schistosoma mansoni hypothetical protein 0.05 0.2011 0.1989
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0066
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0073 0.0094 0.0066
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0262 0.0398
Onchocerca volvulus 0.0111 0.0262 0.1589
Onchocerca volvulus 0.0073 0.0094 0.0568
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0066
Toxoplasma gondii subtilisin SUB5 0.0111 0.0262 0.459
Echinococcus granulosus protein will die slowly 0.0068 0.007 0.0042
Echinococcus multilocularis neuropeptide Y receptor 0.0073 0.0094 0.0075
Trypanosoma cruzi CYC2-like cyclin, putative 0.015 0.044 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0262 0.0398
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.0094 0.0066
Echinococcus granulosus biogenic amine 5HT receptor 0.0073 0.0094 0.0066
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0163 0.0496 0.0469
Echinococcus multilocularis Furin 1 0.0663 0.2741 0.3096
Onchocerca volvulus 0.0073 0.0094 0.0568
Echinococcus multilocularis serotonin receptor 0.0073 0.0094 0.0075
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.0094 0.0066
Brugia malayi G-protein coupled receptor 0.0073 0.0094 0.0066
Onchocerca volvulus 0.0073 0.0094 0.0568
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0262 0.0398
Loa Loa (eye worm) hypothetical protein 0.0419 0.1648 0.1625
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0073 0.0094 0.0066
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0073 0.0094 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.05 0.2011 0.3637
Toxoplasma gondii subtilisin SUB4 0.0111 0.0262 0.459
Echinococcus granulosus g protein coupled receptor 0.0073 0.0094 0.0066
Plasmodium vivax subtilisin-like protease 2, putative 0.0111 0.0262 0.5206
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0066
Brugia malayi Protein kinase domain containing protein 0.0087 0.0156 0.0129
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0094 0.0066
Trichomonas vaginalis cyclins, putative 0.015 0.044 0.0729
Echinococcus multilocularis neuropeptide receptor A26 0.0073 0.0094 0.0075
Giardia lamblia Furin precursor putative serine protease 0.0553 0.2245 0.8268
Echinococcus multilocularis tissue type plasminogen activator 0.0132 0.0359 0.0378
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0111 0.0262 0.0235
Trypanosoma cruzi cdc2-related kinase 3 0.0087 0.0156 0.1572
Trypanosoma brucei subtilisin peptidase 0.0111 0.0262 0.3715
Echinococcus granulosus neuropeptide receptor 0.0073 0.0094 0.0066
Onchocerca volvulus 0.0073 0.0094 0.0568
Loa Loa (eye worm) hypothetical protein 0.0419 0.1648 0.1625
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0553 0.2245 0.4071
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0262 0.0398
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0073 0.0094 0.0066
Loa Loa (eye worm) hypothetical protein 0.015 0.044 0.0414
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0073 0.0094 0.0066
Echinococcus multilocularis neuropeptide Y receptor 0.0073 0.0094 0.0075
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0427 0.1682 0.1658
Echinococcus multilocularis neuropeptides capa receptor 0.0073 0.0094 0.0075
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0073 0.0094 0.0075
Echinococcus granulosus 7tm_1 domain containing protein 0.0073 0.0094 0.0066
Brugia malayi Cyclin, N-terminal domain containing protein 0.015 0.044 0.0414
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0066
Echinococcus multilocularis g protein coupled receptor 0.0073 0.0094 0.0075
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0073 0.0094 0.0066
Brugia malayi G-protein coupled receptor 0.0073 0.0094 0.0066
Brugia malayi RE15519p 0.0073 0.0094 0.0066
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0066
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0073 0.0094 0.0066
Echinococcus multilocularis cyclins 0.0063 0.0047 0.0022
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0073 0.0094 0.0075
Echinococcus granulosus tm gpcr rhodopsin 0.0073 0.0094 0.0066
Schistosoma mansoni neuropeptide F-like receptor 0.0073 0.0094 0.0066
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.0094 0.0066
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0073 0.0094 0.0066
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.0094 0.0066
Echinococcus granulosus serotonin receptor 0.0073 0.0094 0.0066
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0073 0.0094 0.0075
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0111 0.0262 0.0235
Echinococcus multilocularis g protein coupled receptor 0.0073 0.0094 0.0075
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.0092 0.0179 0.0173
Plasmodium falciparum DNA polymerase delta catalytic subunit 0.0092 0.0179 0.4237
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0073 0.0094 0.0066
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0066
Brugia malayi GnHR receptor homolog 0.0073 0.0094 0.0066
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0066
Onchocerca volvulus 0.0073 0.0094 0.0568
Brugia malayi larval opioid receptor 0.0073 0.0094 0.0066
Trypanosoma cruzi subtilisin peptidase 0.0111 0.0262 0.4703
Loa Loa (eye worm) neuropeptide F receptor 0.0073 0.0094 0.0066
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0262 0.0398
Giardia lamblia DNA polymerase delta, catalytic subunit 0.0092 0.0179 0.0497
Echinococcus granulosus neuropeptides capa receptor 0.0073 0.0094 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0262 0.0398
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0262 0.0398
Loa Loa (eye worm) proprotein convertase 2 0.0663 0.2741 0.2721
Brugia malayi hypothetical protein 0.0073 0.0094 0.0066
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0066
Echinococcus multilocularis G-protein coupled receptor, putative 0.0073 0.0094 0.0075
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0073 0.0094 0.0075
Brugia malayi Dopamine receptor protein 2 0.0073 0.0094 0.0066
Trichomonas vaginalis CMGC family protein kinase 0.0087 0.0156 0.0203
Onchocerca volvulus 0.0132 0.0359 0.2178
Schistosoma mansoni adenoreceptor 0.0073 0.0094 0.0066
Brugia malayi hypothetical protein 0.0073 0.0094 0.0066
Echinococcus multilocularis fmrfamide receptor 0.0073 0.0094 0.0075
Brugia malayi putative neuropeptide receptor 0.0073 0.0094 0.0066
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0094 0.0066
Brugia malayi neuropeptide F receptor 0.0073 0.0094 0.0066
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0663 0.2741 0.4989
Toxoplasma gondii subtilisin SUB8 0.0111 0.0262 0.459
Loa Loa (eye worm) G-protein coupled receptor 0.0073 0.0094 0.0066
Echinococcus granulosus orexin receptor type 2 0.0073 0.0094 0.0066
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0262 0.0398
Plasmodium falciparum subtilisin-like protease 3 0.0111 0.0262 0.6887
Brugia malayi hypothetical protein 0.0073 0.0094 0.0066
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0066
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0073 0.0094 0.0066
Leishmania major hypothetical protein, conserved 0.0132 0.0359 0.7135
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative 0.0092 0.0179 0.3361
Trichomonas vaginalis conserved hypothetical protein 0.05 0.2011 0.3637
Schistosoma mansoni growth hormone secretagogue receptor 0.0073 0.0094 0.0066
Trichomonas vaginalis cyclin A, putative 0.015 0.044 0.0729
Brugia malayi hypothetical protein 0.0073 0.0094 0.0066
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.0092 0.0179 0.0152
Brugia malayi putative neuropeptide receptor NPR1 0.0073 0.0094 0.0066
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0073 0.0094 0.0066
Echinococcus granulosus furin 0.2281 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0066
Schistosoma mansoni biogenic amine receptor 0.0073 0.0094 0.0066
Mycobacterium leprae Possible secreted protease 0.0111 0.0262 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0073 0.0094 0.0066
Loa Loa (eye worm) hypothetical protein 0.0086 0.0152 0.0125
Trichomonas vaginalis retinoblastoma binding protein, putative 0.0072 0.009 0.008
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0663 0.2741 0.4989
Onchocerca volvulus 0.0073 0.0094 0.0568
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0262 0.0398
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0094 0.0075
Trichomonas vaginalis WD repeat domain, putative 0.0068 0.007 0.0043
Plasmodium vivax DNA polymerase delta catalytic subunit, putative 0.0092 0.0179 0.1124
Onchocerca volvulus 0.0073 0.0094 0.0568
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0094 0.0075
Echinococcus granulosus cyclin dependent kinase 5 0.0087 0.0156 0.0129
Echinococcus granulosus g protein coupled receptor 0.0073 0.0094 0.0066
Loa Loa (eye worm) hypothetical protein 0.0111 0.0262 0.0235
Echinococcus multilocularis cyclins 0.0063 0.0047 0.0022
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0663 0.2741 0.4989
Echinococcus multilocularis serotonin receptor 0.0073 0.0094 0.0075
Onchocerca volvulus 0.0073 0.0094 0.0568
Brugia malayi neuroendocrine convertase 1 precursor 0.2007 0.8773 0.877
Echinococcus granulosus cyclin dependent kinase 0.0087 0.0156 0.0129
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0262 0.0398
Schistosoma mansoni site-1 peptidase (S08 family) 0.0111 0.0262 0.0235
Onchocerca volvulus 0.0058 0.0028 0.0169
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0073 0.0094 0.0066
Schistosoma mansoni amine GPCR 0.0073 0.0094 0.0066
Echinococcus granulosus membrane bound transcription factor site 1 0.0111 0.0262 0.0235
Echinococcus multilocularis neuropeptide s receptor 0.0073 0.0094 0.0075
Echinococcus multilocularis epidermal growth factor receptor 0.0273 0.0993 0.1101
Echinococcus multilocularis g-protein coupled receptor 0.0073 0.0094 0.0075
Echinococcus multilocularis cyclin dependent kinase 1 0.0087 0.0156 0.0147
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0066
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0111 0.0262 0.5
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.015 0.044 1
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.05 0.2011 0.3637
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0262 0.0398
Entamoeba histolytica cyclin, putative 0.015 0.044 1
Toxoplasma gondii subtilisin SUB12 0.0138 0.0386 1
Brugia malayi celfurPC protein 0.178 0.7755 0.7748
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.1266 0.5447 0.5434
Trypanosoma cruzi cyclin 6, putative 0.015 0.044 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0073 0.0094 0.0066
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0066
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0114 0.0279 0.521
Trichomonas vaginalis hypothetical protein 0.05 0.2011 0.3637
Leishmania major subtilisin-like serine peptidase 0.0111 0.0262 0.3715
Schistosoma mansoni neuropeptide receptor 0.0073 0.0094 0.0066
Brugia malayi cell division control protein 2 homolog 0.0087 0.0156 0.0129
Echinococcus multilocularis g protein coupled receptor 0.0073 0.0094 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.05 0.2011 0.3637
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0066
Loa Loa (eye worm) WD40 repeat protein 0.0068 0.007 0.0042
Trichomonas vaginalis cyclins, putative 0.0103 0.0227 0.0333
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0066
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0111 0.0262 0.5
Trypanosoma brucei mitotic cyclin 6 0.015 0.044 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0073 0.0094 0.0066
Brugia malayi neuropeptide F receptor 0.0073 0.0094 0.0066
Schistosoma mansoni amine GPCR 0.0073 0.0094 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.05 0.2011 0.3637
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.2281 1 1
Onchocerca volvulus 0.0073 0.0094 0.0568
Onchocerca volvulus 0.0073 0.0094 0.0568
Brugia malayi Dopamine receptor 0.0073 0.0094 0.0066
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0066
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0262 0.0398
Echinococcus multilocularis cyclin dependent kinase 1 0.0087 0.0156 0.0147
Schistosoma mansoni amine GPCR 0.0073 0.0094 0.0066
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1266 0.5447 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0073 0.0094 0.0075
Brugia malayi hypothetical protein 0.0073 0.0094 0.0066
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.1266 0.5447 0.6183
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0063 0.0047 0.0022
Echinococcus granulosus dro:myosuppressin receptor 0.0073 0.0094 0.0066
Onchocerca volvulus 0.0073 0.0094 0.0568
Trichomonas vaginalis conserved hypothetical protein 0.05 0.2011 0.3637
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0114 0.0279 0.521
Schistosoma mansoni furin-1 (S08 family) 0.1125 0.4815 0.48
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0066
Echinococcus granulosus g-protein coupled receptor 0.0073 0.0094 0.0066
Echinococcus multilocularis dro:myosuppressin receptor 0.0073 0.0094 0.0075
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0066
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0094 0.0075
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0073 0.0094 0.0066
Loa Loa (eye worm) subtilase 0.0111 0.0262 0.0235
Schistosoma mansoni hypothetical protein 0.0132 0.0359 0.0332
Entamoeba histolytica cell division protein kinase 2, putative 0.0087 0.0156 0.2782
Plasmodium falciparum protein kinase 5 0.0087 0.0156 0.3507
Onchocerca volvulus 0.0058 0.0028 0.0169
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0066
Echinococcus multilocularis cyclins 0.0063 0.0047 0.0022
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0073 0.0094 0.0066
Echinococcus multilocularis fmrfamide receptor 0.0073 0.0094 0.0075
Onchocerca volvulus 0.0073 0.0094 0.0568
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0073 0.0094 0.0075
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0073 0.0094 0.0066
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0073 0.0094 0.0066
Brugia malayi G protein-coupled receptor F59B2.13 0.0073 0.0094 0.0066
Schistosoma mansoni serine/threonine protein kinase 0.0087 0.0156 0.0129
Echinococcus multilocularis wd40 repeat 0.0072 0.009 0.0071
Loa Loa (eye worm) hypothetical protein 0.0072 0.009 0.0062
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0663 0.2741 0.4989
Brugia malayi hypothetical protein 0.0073 0.0094 0.0066
Echinococcus multilocularis allatostatin A receptor 0.0073 0.0094 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.05 0.2011 0.3637
Trichomonas vaginalis cyclins, putative 0.015 0.044 0.0729
Brugia malayi Cyclin, N-terminal domain containing protein 0.015 0.044 0.0414
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0262 0.0398
Plasmodium falciparum subtilisin-like protease 1 0.0111 0.0262 0.6887
Onchocerca volvulus 0.0058 0.0028 0.0169
Echinococcus granulosus epidermal growth factor receptor 0.0273 0.0993 0.0968
Brugia malayi hypothetical protein 0.0073 0.0094 0.0066
Brugia malayi sulfakinin receptor protein 0.0073 0.0094 0.0066
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0094 0.0066
Trypanosoma cruzi cdc2-related kinase 1 0.0087 0.0156 0.1572
Loa Loa (eye worm) hypothetical protein 0.2281 1 1
Echinococcus granulosus hypothetical protein 0.0073 0.0094 0.0066
Echinococcus granulosus sex peptide receptor 0.0073 0.0094 0.0066
Echinococcus multilocularis dnaJ subfamily B 0.2012 0.8793 1
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0111 0.0262 0.0235
Echinococcus granulosus neuropeptide receptor A26 0.0073 0.0094 0.0066
Loa Loa (eye worm) hypothetical protein 0.0382 0.1479 0.1455
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0262 0.0398
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0066
Schistosoma mansoni neuropeptide receptor 0.0073 0.0094 0.0066
Brugia malayi Dopamine receptor protein 1 0.0073 0.0094 0.0066
Echinococcus granulosus neuropeptide receptor 0.0073 0.0094 0.0066
Giardia lamblia High cysteine membrane protein Group 2 0.0655 0.2705 1
Schistosoma mansoni hypothetical protein 0.0068 0.007 0.0042
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0262 0.0398
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0663 0.2741 0.2721
Echinococcus granulosus allatostatin A receptor 0.0073 0.0094 0.0066
Trichomonas vaginalis cyclin B, putative 0.015 0.044 0.0729
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0066
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0262 0.0398
Brugia malayi Tachykinin-like peptides receptor 99D 0.0779 0.3261 0.3242
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0066
Echinococcus granulosus tissue type plasminogen activator 0.0132 0.0359 0.0332
Schistosoma mansoni neuropeptide receptor 0.0073 0.0094 0.0066
Echinococcus multilocularis cyclin B3 1 0.0063 0.0047 0.0022
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0073 0.0094 0.0066
Onchocerca volvulus 0.0361 0.1386 0.8409
Onchocerca volvulus 0.0058 0.0028 0.0169
Echinococcus granulosus fmrfamide receptor 0.0073 0.0094 0.0066
Loa Loa (eye worm) neuropeptide F receptor 0.0073 0.0094 0.0066
Schistosoma mansoni biogenic amine (5HT) receptor 0.0073 0.0094 0.0066
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0073 0.0094 0.0066
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1266 0.5447 1
Echinococcus multilocularis cyclins 0.0063 0.0047 0.0022
Trypanosoma cruzi cdc2-related kinase 1 0.0087 0.0156 0.1572
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0063 0.0047 0.0019
Toxoplasma gondii subtilisin SUB10 0.0111 0.0262 0.459
Schistosoma mansoni cyclins 0.0063 0.0047 0.0019
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0073 0.0094 0.0066
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0073 0.0094 0.0066
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0066
Trichomonas vaginalis cyclin B, putative 0.015 0.044 0.0729
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0663 0.2741 0.4989
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0073 0.0094 0.0066
Echinococcus granulosus tachykinin peptides receptor 99D 0.0073 0.0094 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.05 0.2011 0.3637
Schistosoma mansoni neuropeptide receptor 0.0073 0.0094 0.0066
Onchocerca volvulus 0.0073 0.0094 0.0568
Echinococcus granulosus Furin 1 0.0663 0.2741 0.2721
Schistosoma mansoni serine/threonine protein kinase 0.0087 0.0156 0.0129
Toxoplasma gondii subtilisin SUB6 0.0111 0.0262 0.459
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0094 0.0066
Brugia malayi G protein-coupled receptor 0.0073 0.0094 0.0066
Schistosoma mansoni histamine h1 receptor 0.0073 0.0094 0.0066
Trichomonas vaginalis cyclins, putative 0.015 0.044 0.0729
Plasmodium vivax subtilisin-like protease 1 0.0111 0.0262 0.5206
Trypanosoma cruzi cdc2-related kinase 3 0.0087 0.0156 0.1572
Schistosoma mansoni retinoblastoma binding protein 0.0072 0.009 0.0062
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative 0.0092 0.0179 0.0245
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0066
Echinococcus granulosus cyclin B 0.015 0.044 0.0414
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0066
Trichomonas vaginalis cyclins, putative 0.015 0.044 0.0729
Loa Loa (eye worm) hypothetical protein 0.0779 0.3261 0.3242
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0073 0.0094 0.0075
Echinococcus granulosus neuroendocrine convertase 2 0.1678 0.7294 0.7287
Onchocerca volvulus 0.0073 0.0094 0.0568
Schistosoma mansoni neuropeptide f receptor 76f 0.0073 0.0094 0.0066
Trypanosoma cruzi cyclin, putative 0.015 0.044 1
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0111 0.0262 1
Onchocerca volvulus 0.0073 0.0094 0.0568
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0066
Plasmodium vivax subtilisin-like serine protease, putative 0.0111 0.0262 0.5206
Loa Loa (eye worm) hypothetical protein 0.015 0.044 0.0414
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0262 0.0398
Echinococcus granulosus alpha 1A adrenergic receptor 0.0073 0.0094 0.0066
Trichomonas vaginalis cyclin B, putative 0.015 0.044 0.0729
Trichomonas vaginalis conserved hypothetical protein 0.05 0.2011 0.3637
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0111 0.0262 0.5
Leishmania major DNA polymerase delta catalytic subunit, putative 0.0092 0.0179 0.0802
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0073 0.0094 0.0066
Echinococcus multilocularis somatostatin receptor 0.0073 0.0094 0.0075
Echinococcus multilocularis sex peptide receptor 0.0073 0.0094 0.0075
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0094 0.0075
Onchocerca volvulus DNA polymerase delta catalytic subunit homolog 0.0092 0.0179 0.1087
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0262 0.0398
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0066
Trypanosoma brucei RNA helicase, putative 0.0104 0.0231 0.2635
Trypanosoma cruzi cyclin, putative 0.015 0.044 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0262 0.0398
Trypanosoma cruzi hypothetical protein, conserved 0.0132 0.0359 0.7586
Loa Loa (eye worm) melatonin receptor type 1A 0.0073 0.0094 0.0066
Schistosoma mansoni site-1 peptidase (S08 family) 0.0111 0.0262 0.0235
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0073 0.0094 0.0075
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0111 0.0262 0.0235
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0066
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0073 0.0094 0.0066
Leishmania major cyclin 0.015 0.044 1
Echinococcus granulosus dnaJ subfamily B 0.2012 0.8793 0.879
Onchocerca volvulus 0.0073 0.0094 0.0568
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0073 0.0094 0.0066
Echinococcus granulosus cyclins 0.0063 0.0047 0.0019
Brugia malayi ORL1-like opioid receptor 0.0073 0.0094 0.0066
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0073 0.0094 0.0075
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0094 0.0066
Echinococcus granulosus tm gpcr rhodopsin 0.0073 0.0094 0.0066
Echinococcus granulosus cyclin b3 0.0063 0.0047 0.0019
Toxoplasma gondii subtilisin SUB2 0.0111 0.0262 0.459
Brugia malayi proprotein convertase 2 0.1678 0.7294 0.7287
Onchocerca volvulus 0.0058 0.0028 0.0169
Schistosoma mansoni tyrosine kinase 0.0273 0.0993 0.0968
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0419 0.1648 0.1625
Toxoplasma gondii subtilisin SUB7 0.0111 0.0262 0.459
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.0094 0.0066
Toxoplasma gondii subtilisin SUB11 0.0111 0.0262 0.459
Schistosoma mansoni hypothetical protein 0.0073 0.0094 0.0066
Brugia malayi Serotonin receptor 0.0073 0.0094 0.0066
Schistosoma mansoni neuropeptide F-like receptor 0.0073 0.0094 0.0066
Echinococcus granulosus cyclin B3 1 0.0063 0.0047 0.0019
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0111 0.0262 0.0398
Toxoplasma gondii subtilisin SUB1 0.0111 0.0262 0.459
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0073 0.0094 0.0075
Echinococcus granulosus cyclins 0.0063 0.0047 0.0019

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 8 uM Inhibitory activity against Human Cytomegalovirus (HCMV) polymerase ChEMBL. 10999475
IC50 (binding) = 8 uM Inhibitory activity against Human Cytomegalovirus (HCMV) polymerase ChEMBL. 10999475

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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