TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 491.737 | Formula: C30H41NO3Si
H donors: 1 H acceptors: 1 LogP: 6.99 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCO/C(=C/C1=N[C@]2(CCC1)CCC[C@@H]2CO[Si](C(C)(C)C)(c1ccccc1)c1ccccc1)/O
InChi: 1S/C30H41NO3Si/c1-5-33-28(32)22-25-15-13-21-30(31-25)20-12-14-24(30)23-34-35(29(2,3)4,26-16-8-6-9-17-26)27-18-10-7-11-19-27/h6-11,16-19,22,24,32H,5,12-15,20-21,23H2,1-4H3/b28-22+/t24-,30+/m1/s1
InChiKey: AFJSJJQOJUISJH-WUILFJRESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0058	0.0072	0.0047
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0914	0.2824	0.5031
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0232	0.0633	0.061
Toxoplasma gondii	PAN domain-containing protein	0.0323	0.0923	1
Trichomonas vaginalis	WD repeat domain, putative	0.0066	0.0098	0.0073
Echinococcus multilocularis	Furin 1	0.0914	0.2824	0.3596
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0151	0.0371	0.0569
Mycobacterium leprae	PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3)	0.0151	0.0371	1
Trypanosoma cruzi	serine peptidase, clan SB, family S8-like protein	0.0151	0.0371	0.5686
Trypanosoma cruzi	subtilisin peptidase	0.0151	0.0371	0.5686
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0072	0.0047
Giardia lamblia	Glycogen phosphorylase	0.0191	0.0499	0.1563
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0914	0.2824	0.5031
Schistosoma mansoni	glycogen phosphorylase	0.0191	0.0499	0.0475
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0305	0.0868	0.0845
Toxoplasma gondii	histone deacetylase HDAC3	0.0053	0.0058	0.0627
Brugia malayi	hypothetical protein	0.0063	0.009	0.0065
Toxoplasma gondii	subtilisin SUB11	0.0151	0.0371	0.4017
Trichomonas vaginalis	conserved hypothetical protein	0.0151	0.0371	0.0569
Schistosoma mansoni	lipoxygenase	0.0057	0.0068	0.0043
Echinococcus multilocularis	histone deacetylase 3	0.0053	0.0058	0.0042
Trichomonas vaginalis	hypothetical protein	0.0682	0.2078	0.3673
Echinococcus multilocularis	pol protein	0.0156	0.0387	0.0464
Echinococcus granulosus	tar DNA binding protein	0.0047	0.0036	0.0011
Echinococcus granulosus	neuroendocrine convertase 2	0.2297	0.7267	0.726
Echinococcus multilocularis	enteropeptidase	0.018	0.0466	0.0566
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0104	0.0219	0.3318
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.3147	1	1
Brugia malayi	celfurPC protein	0.2465	0.7809	0.7803
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0104	0.0219	0.3036
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0058	0.0072	0.0047
Trichomonas vaginalis	conserved hypothetical protein	0.0682	0.2078	0.3673
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0072	0.0047
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0151	0.0371	0.0569
Brugia malayi	RNA recognition motif domain containing protein	0.0047	0.0036	0.0011
Loa Loa (eye worm)	glycogen phosphorylase	0.0191	0.0499	0.0475
Loa Loa (eye worm)	hypothetical protein	0.0328	0.0941	0.0918
Echinococcus multilocularis	epidermal growth factor receptor	0.0348	0.1004	0.1258
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0348	0.1004	0.0981
Echinococcus multilocularis	fibrillin 1	0.0058	0.0074	0.0062
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0151	0.0371	0.0569
Trichomonas vaginalis	neuroendocrine convertase 2 precursor, putative	0.0764	0.234	0.415
Mycobacterium ulcerans	proline rich membrane-anchored mycosin MycP5	0.0151	0.0371	1
Brugia malayi	Histone deacetylase 1	0.0053	0.0058	0.0033
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0058	0.0072	0.006
Trichomonas vaginalis	conserved hypothetical protein	0.0682	0.2078	0.3673
Onchocerca volvulus		0.0058	0.0072	0.047
Echinococcus multilocularis	Peptidase S8 S53, subtilisin kexin sedolisin	0.0151	0.0371	0.0444
Loa Loa (eye worm)	MH2 domain-containing protein	0.0085	0.016	0.0135
Loa Loa (eye worm)	trypsin family protein	0.0058	0.0072	0.0047
Brugia malayi	Hypothetical tyrosinase-like protein F21C3.2 in chromosome I	0.0305	0.0868	0.0845
Schistosoma mansoni	tar DNA-binding protein	0.0047	0.0036	0.0011
Mycobacterium tuberculosis	Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like)	0.0151	0.0371	1
Echinococcus multilocularis	sentrin specific protease 7	0.0141	0.034	0.0405
Mycobacterium leprae	Possible secreted protease	0.0151	0.0371	1
Schistosoma mansoni	hypothetical protein	0.0149	0.0365	0.0341
Schistosoma mansoni	hypothetical protein	0.0237	0.0647	0.0623
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0371	0.0347
Loa Loa (eye worm)	ShTK domain-containing protein	0.0305	0.0868	0.0845
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0151	0.0371	0.0569
Loa Loa (eye worm)	hypothetical protein	0.1464	0.4592	0.4578
Echinococcus multilocularis	protein will die slowly	0.0066	0.0098	0.0094
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0151	0.0371	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0072	0.0047
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0058	0.0072	0.0047
Loa Loa (eye worm)	proprotein convertase 2	0.0914	0.2824	0.2806
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0914	0.2824	0.5031
Loa Loa (eye worm)	hypothetical protein	0.0073	0.012	0.0095
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0058	0.0072	0.006
Onchocerca volvulus		0.0305	0.0868	0.8491
Loa Loa (eye worm)	subtilase	0.0151	0.0371	0.0347
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0151	0.0371	0.0569
Onchocerca volvulus		0.0305	0.0868	0.8491
Schistosoma mansoni	tripeptidyl-peptidase II (S08 family)	0.0151	0.0371	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0072	0.0047
Echinococcus multilocularis	membrane bound transcription factor site 1	0.0151	0.0371	0.0444
Toxoplasma gondii	subtilisin SUB7	0.0151	0.0371	0.4017
Schistosoma mansoni	cercarial elastase (S01 family)	0.0058	0.0072	0.0047
Entamoeba histolytica	glycogen phosphorylase, putative	0.0082	0.0152	0.2122
Schistosoma mansoni	glycogen phosphorylase	0.0082	0.0152	0.0127
Schistosoma mansoni	histone deacetylase	0.0053	0.0058	0.0033
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.018	0.0466	0.0442
Onchocerca volvulus		0.0058	0.0072	0.047
Trypanosoma cruzi	histone deacetylase 1, putative	0.0053	0.0058	0.0794
Schistosoma mansoni	glycogen phosphorylase	0.0191	0.0499	0.0475
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0151	0.0371	0.0569
Onchocerca volvulus		0.0294	0.0831	0.8119
Onchocerca volvulus		0.0066	0.0098	0.0736
Plasmodium vivax	subtilisin-like serine protease, putative	0.0151	0.0371	0.5314
Schistosoma mansoni	hypothetical protein	0.005	0.0046	0.0021
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.008	0.0143	0.1013
Plasmodium falciparum	subtilisin-like protease 1	0.0151	0.0371	0.5314
Onchocerca volvulus		0.0058	0.0072	0.047
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0151	0.0371	0.0569
Echinococcus granulosus	Glycosyl transferase family 35	0.0191	0.0499	0.0475
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0058	0.0072	0.0047
Echinococcus granulosus	Mastin	0.018	0.0466	0.0442
Trichomonas vaginalis	conserved hypothetical protein	0.0682	0.2078	0.3673
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0043	0.0025	0.0272
Brugia malayi	Furin-like cysteine rich region family protein	0.0348	0.1004	0.0981
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.1765	0.5557	1
Echinococcus granulosus	transmembrane protease serine 3	0.0058	0.0072	0.0047
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0305	0.0868	0.0845
Onchocerca volvulus		0.0305	0.0868	0.8491
Echinococcus multilocularis	Glycosyl transferase, family 35	0.0191	0.0499	0.0609
Brugia malayi	MH2 domain containing protein	0.0085	0.016	0.0135
Brugia malayi	hypothetical protein	0.0058	0.0072	0.0047
Brugia malayi	Common central domain of tyrosinase family protein	0.0305	0.0868	0.0845
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0219	0.059	0.9106
Trichomonas vaginalis	conserved hypothetical protein	0.0682	0.2078	0.3673
Echinococcus multilocularis	Mastin	0.018	0.0466	0.0566
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0914	0.2824	0.5031
Echinococcus granulosus	rho-associated protein kinase 1	0.0294	0.0831	0.0808
Entamoeba histolytica	glycogenphosphorylase, putative	0.0082	0.0152	0.2122
Schistosoma mansoni	cercarial elastase (S01 family)	0.0058	0.0072	0.0047
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0058	0.0072	0.0047
Schistosoma mansoni	hypothetical protein	0.0682	0.2078	0.2058
Echinococcus multilocularis	rho associated protein kinase	0.0294	0.0831	0.1036
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0072	0.0047
Onchocerca volvulus		0.0293	0.0829	0.8099
Schistosoma mansoni	histone deacetylase	0.0053	0.0058	0.0033
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4)	0.0151	0.0371	1
Brugia malayi	carbohydrate phosphorylase	0.0191	0.0499	0.0475
Echinococcus granulosus	epidermal growth factor receptor	0.0348	0.1004	0.0981
Schistosoma mansoni	cercarial elastase (S01 family)	0.0058	0.0072	0.0047
Echinococcus granulosus	protein will die slowly	0.0066	0.0098	0.0073
Brugia malayi	histone deacetylase 3 (HD3)	0.0053	0.0058	0.0033
Echinococcus granulosus	glycogen phosphorylase	0.0191	0.0499	0.0475
Toxoplasma gondii	subtilisin SUB8	0.0151	0.0371	0.4017
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0151	0.0371	0.0569
Schistosoma mansoni	integrin beta subunit	0.0245	0.0675	0.0652
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0073	0.012	0.0095
Brugia malayi	histone deacetylase 1 (HD1)	0.0053	0.0058	0.0033
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0151	0.0371	0.0569
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0232	0.0633	0.1046
Echinococcus multilocularis	integrin beta 2	0.0309	0.0879	0.1097
Brugia malayi	nuclear hormone receptor	0.0339	0.0977	0.0954
Mycobacterium ulcerans	membrane-anchored serine protease (mycosin), MycP4	0.0151	0.0371	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0151	0.0371	0.0569
Brugia malayi	TAR-binding protein	0.0047	0.0036	0.0011
Echinococcus multilocularis	glycoprotein Antigen 5	0.018	0.0466	0.0566
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3)	0.0151	0.0371	1
Loa Loa (eye worm)	TK/ROR protein kinase	0.0237	0.0647	0.0623
Echinococcus granulosus	histone deacetylase 3	0.0053	0.0058	0.0033
Loa Loa (eye worm)	AGC/DMPK/ROCK protein kinase	0.0913	0.2821	0.2803
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0151	0.0371	0.0569
Trichomonas vaginalis	conserved hypothetical protein	0.0151	0.0371	0.0569
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0151	0.0371	0.0569
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0058	0.0072	0.0047
Trichomonas vaginalis	conserved hypothetical protein	0.0151	0.0371	0.0569
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0151	0.0371	0.0569
Trichomonas vaginalis	conserved hypothetical protein	0.0082	0.0149	0.0166
Giardia lamblia	Furin precursor putative serine protease	0.0764	0.234	0.8082
Toxoplasma gondii	subtilisin SUB9	0.0151	0.0371	0.4017
Echinococcus multilocularis	tar DNA binding protein	0.0047	0.0036	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0063	0.009	0.0065
Brugia malayi	Trypsin family protein	0.0058	0.0072	0.0047
Echinococcus multilocularis	glycogen phosphorylase	0.0191	0.0499	0.0609
Brugia malayi	neuroendocrine convertase 1 precursor	0.2607	0.8264	0.8259
Schistosoma mansoni	tar DNA-binding protein	0.0047	0.0036	0.0011
Schistosoma mansoni	serine/threonine protein kinase	0.0294	0.0831	0.0808
Trypanosoma brucei	serine peptidase, clan SB, family S8-like protein	0.0151	0.0371	0.5885
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.008	0.0143	0.1013
Leishmania major	subtilisin-like serine peptidase	0.0151	0.0371	0.5314
Schistosoma mansoni	tar DNA-binding protein	0.0047	0.0036	0.0011
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.1765	0.5557	1
Brugia malayi	Trypsin-like protease protein 5	0.0058	0.0072	0.0047
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0151	0.0371	0.0569
Entamoeba histolytica	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0141	0.034	0.6393
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0176	0.0453	0.0429
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0072	0.0047
Entamoeba histolytica	glycogen phosphorylase, putative	0.0191	0.0499	1
Mycobacterium tuberculosis	Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5)	0.0151	0.0371	1
Echinococcus granulosus	histone deacetylase 1	0.0053	0.0058	0.0033
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.008	0.0143	0.1013
Echinococcus granulosus	peptidase s8 s53 subtilisin kexin sedolisin	0.0151	0.0371	0.0347
Brugia malayi	Trypsin family protein	0.0058	0.0072	0.0047
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0058	0.0072	0.0047
Onchocerca volvulus		0.0058	0.0072	0.047
Brugia malayi	Protein kinase domain containing protein	0.0237	0.0647	0.0623
Schistosoma mansoni	tar DNA-binding protein	0.0047	0.0036	0.0011
Echinococcus granulosus	expressed conserved protein	0.0118	0.0267	0.0243
Trichomonas vaginalis	conserved hypothetical protein	0.0682	0.2078	0.3673
Brugia malayi	proprotein convertase 2	0.2297	0.7267	0.726
Loa Loa (eye worm)	histone deacetylase 1	0.0053	0.0058	0.0033
Schistosoma mansoni	cercarial elastase (S01 family)	0.0058	0.0072	0.0047
Brugia malayi	Protein kinase domain containing protein	0.0913	0.2821	0.2803
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0151	0.0371	0.0569
Echinococcus multilocularis	pol protein	0.0156	0.0387	0.0464
Echinococcus granulosus	enteropeptidase	0.018	0.0466	0.0442
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0151	0.0371	0.0347
Plasmodium falciparum	subtilisin-like protease 2	0.0151	0.0371	0.5314
Loa Loa (eye worm)	hypothetical protein	0.0305	0.0868	0.0845
Echinococcus granulosus	furin	0.3147	1	1
Echinococcus multilocularis	expressed conserved protein	0.0118	0.0267	0.0311
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0151	0.0371	0.0569
Brugia malayi	Integrin beta pat-3 precursor	0.0417	0.1226	0.1204
Schistosoma mansoni	family C48 unassigned peptidase (C48 family)	0.0141	0.034	0.0316
Loa Loa (eye worm)	integrin beta-2	0.0417	0.1226	0.1204
Echinococcus multilocularis	pol protein	0.0156	0.0387	0.0464
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0914	0.2824	0.5031
Brugia malayi	Trypsin family protein	0.0058	0.0072	0.0047
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0219	0.059	0.9106
Loa Loa (eye worm)	WD40 repeat protein	0.0066	0.0098	0.0073
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0058	0.0072	0.0047
Onchocerca volvulus	Glycogen phosphorylase homolog	0.0191	0.0499	0.4777
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0058	0.0033
Trypanosoma brucei	subtilisin peptidase	0.0151	0.0371	0.5885
Mycobacterium tuberculosis	Probable glycogen phosphorylase GlgP	0.0082	0.0152	0.1364
Schistosoma mansoni	hypothetical protein	0.0066	0.0098	0.0073
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0151	0.0371	0.0569
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0151	0.0371	0.0569
Schistosoma mansoni	lipoxygenase	0.0081	0.0147	0.0122
Brugia malayi	Kringle domain containing protein	0.0237	0.0647	0.0623
Giardia lamblia	High cysteine membrane protein Group 2	0.0932	0.2882	1
Echinococcus multilocularis	neuroendocrine convertase 2	0.2297	0.7267	0.9304
Echinococcus granulosus	tissue type plasminogen activator	0.0237	0.0647	0.0623
Toxoplasma gondii	subtilisin SUB1	0.0151	0.0371	0.4017
Toxoplasma gondii	kringle domain-containing protein	0.0237	0.0647	0.7007
Plasmodium falciparum	subtilisin-like protease 3	0.0151	0.0371	0.5314
Trichomonas vaginalis	conserved hypothetical protein	0.0151	0.0371	0.0569
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0305	0.0868	0.0845
Brugia malayi	latrophilin 2 splice variant baaae	0.005	0.0046	0.0021
Toxoplasma gondii	subtilisin SUB4	0.0151	0.0371	0.4017
Schistosoma mansoni	cercarial elastase (S01 family)	0.0058	0.0072	0.0047
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0081	0.0147	0.0122
Schistosoma mansoni	hypothetical protein	0.0149	0.0365	0.0341
Trichomonas vaginalis	conserved hypothetical protein	0.0682	0.2078	0.3673
Schistosoma mansoni	cercarial elastase (S01 family)	0.0058	0.0072	0.0047
Plasmodium vivax	subtilisin-like protease 1	0.0151	0.0371	0.5314
Toxoplasma gondii	subtilisin SUB12	0.0186	0.0483	0.5233
Toxoplasma gondii	subtilisin SUB2	0.0151	0.0371	0.4017
Schistosoma mansoni	tar DNA-binding protein	0.0047	0.0036	0.0011
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0151	0.0371	0.0569
Trichomonas vaginalis	conserved hypothetical protein	0.0682	0.2078	0.3673
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.0914	0.2824	0.2806
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0191	0.0499	0.0803
Toxoplasma gondii	subtilisin SUB5	0.0151	0.0371	0.4017
Mycobacterium tuberculosis	Probable oxidoreductase	0.008	0.0143	0.1013
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0151	0.0371	0.0569
Entamoeba histolytica	glycogen phosphorylase, putative	0.0082	0.0152	0.2122
Toxoplasma gondii	subtilisin SUB6	0.0151	0.0371	0.4017
Echinococcus granulosus	glycogen phosphorylase	0.0191	0.0499	0.0475
Schistosoma mansoni	tyrosinase precursor	0.0305	0.0868	0.0845
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0073	0.012	0.0095
Brugia malayi	ShTK domain containing protein	0.0305	0.0868	0.0845
Trichomonas vaginalis	leucine-rich repeat protein, BspA family	0.0682	0.2078	0.3673
Mycobacterium ulcerans	membrane-anchored mycosin MycP3	0.0151	0.0371	1
Echinococcus multilocularis	geminin	0.0149	0.0365	0.0437
Plasmodium vivax	subtilisin-like protease 2, putative	0.0151	0.0371	0.5314
Brugia malayi	Will die slowly protein	0.0066	0.0098	0.0073
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0914	0.2824	0.5031
Loa Loa (eye worm)	hypothetical protein	0.0305	0.0868	0.0845
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0151	0.0371	0.0569
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0151	0.0371	0.0569
Schistosoma mansoni	hypothetical protein	0.0058	0.0072	0.0047
Plasmodium falciparum	cysteine repeat modular protein 1	0.0237	0.0647	1
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0081	0.0147	0.0156
Loa Loa (eye worm)	TAR-binding protein	0.0047	0.0036	0.0011
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0073	0.012	0.0095
Echinococcus granulosus	geminin	0.0149	0.0365	0.0341
Echinococcus granulosus	Furin 1	0.0914	0.2824	0.2806
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0191	0.0499	0.0803
Echinococcus multilocularis	glycogen phosphorylase	0.0191	0.0499	0.0609
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0339	0.0977	0.0954
Schistosoma mansoni	tyrosine kinase	0.0348	0.1004	0.0981
Brugia malayi	Membrane-bound transcription factor site-1 protease precursor	0.0151	0.0371	0.0347
Onchocerca volvulus		0.0058	0.0072	0.047
Onchocerca volvulus		0.0151	0.0371	0.3481
Toxoplasma gondii	histone deacetylase HDAC2	0.0053	0.0058	0.0627
Schistosoma mansoni	furin-1 (S08 family)	0.1533	0.4814	0.4801
Trichomonas vaginalis	conserved hypothetical protein	0.0682	0.2078	0.3673
Loa Loa (eye worm)	kelch domain-containing protein family protein	0.0063	0.009	0.0065
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0219	0.059	1
Chlamydia trachomatis	glycogen phosphorylase	0.0191	0.0499	0.5
Echinococcus multilocularis	pol protein	0.0156	0.0387	0.0464
Leishmania major	mitochondrial DNA polymerase beta	0.0219	0.059	0.9029
Echinococcus granulosus	integrin beta 2	0.0309	0.0879	0.0856
Schistosoma mansoni	cercarial elastase (S01 family)	0.0058	0.0072	0.0047
Echinococcus multilocularis	histone deacetylase 1	0.0053	0.0058	0.0042
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0151	0.0371	0.0569
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0043	0.0025	0.0272
Brugia malayi	Kelch motif family protein	0.0063	0.009	0.0065
Schistosoma mansoni	cercarial elastase (S01 family)	0.0058	0.0072	0.0047
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0058	0.0072	0.0047
Onchocerca volvulus		0.0305	0.0868	0.8491
Brugia malayi	Subtilase family protein	0.0151	0.0371	0.0347
Echinococcus granulosus	membrane bound transcription factor site 1	0.0151	0.0371	0.0347
Loa Loa (eye worm)	tyrosinase 1	0.0305	0.0868	0.0845
Loa Loa (eye worm)	hypothetical protein	0.3147	1	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0352	0.1018	1
Trypanosoma cruzi	histone deacetylase 1, putative	0.0053	0.0058	0.0794
Echinococcus multilocularis		0.2465	0.7809	1
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0237	0.0647	1
Mycobacterium ulcerans	glycogen phosphorylase GlgP	0.0082	0.0152	0.2669
Schistosoma mansoni	cercarial elastase (S01 family)	0.0058	0.0072	0.0047
Onchocerca volvulus		0.0082	0.0149	0.1253
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.1765	0.5557	0.7107
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0115	0.0257	0.5513
Toxoplasma gondii	subtilisin SUB10	0.0151	0.0371	0.4017
Mycobacterium leprae	PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5)	0.0151	0.0371	1
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0072	0.0047
Trypanosoma cruzi	hypothetical protein, conserved	0.0237	0.0647	1
Entamoeba histolytica	glycogen phosphorylase, putative	0.0191	0.0499	1
Echinococcus multilocularis	tissue type plasminogen activator	0.0237	0.0647	0.0799
Trichomonas vaginalis	conserved hypothetical protein	0.0151	0.0371	0.0569
Echinococcus granulosus	glycoprotein Antigen 5	0.018	0.0466	0.0442
Schistosoma mansoni	tyrosinase precursor	0.0305	0.0868	0.0845
Echinococcus granulosus	sentrin specific protease 7	0.0141	0.034	0.0316
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0047	0.0036	0.0011
Trichomonas vaginalis	conserved hypothetical protein	0.0682	0.2078	0.3673
Loa Loa (eye worm)	hypothetical protein	0.005	0.0046	0.0021
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.1765	0.5557	0.5546
Trichomonas vaginalis	proprotein convertase subtilisin/kexin type, putative	0.0764	0.234	0.415
Onchocerca volvulus		0.0237	0.0647	0.6261
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0151	0.0371	0.5686
Brugia malayi	RNA binding protein	0.0047	0.0036	0.0011
Loa Loa (eye worm)	ShTK domain-containing protein	0.0305	0.0868	0.0845
Loa Loa (eye worm)	hypothetical protein	0.0237	0.0647	0.0623
Loa Loa (eye worm)	histone deacetylase 3	0.0053	0.0058	0.0033
Brugia malayi	Hypothetical subtilase-type proteinase F21H12.6 in chromosome II	0.0151	0.0371	0.0347
Mycobacterium ulcerans	hypothetical protein	0.0115	0.0257	0.6191
Schistosoma mansoni	hypothetical protein	0.0058	0.0072	0.0047
Leishmania major	hypothetical protein, conserved	0.0237	0.0647	1
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0104	0.0219	0.2741
Trichomonas vaginalis	conserved hypothetical protein	0.0682	0.2078	0.3673
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0058	0.0072	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0392	0.1145	0.1123
Echinococcus multilocularis	transmembrane protease serine 3	0.0058	0.0072	0.006
Schistosoma mansoni	cercarial elastase (S01 family)	0.0058	0.0072	0.0047
Loa Loa (eye worm)	transcription factor SMAD2	0.0085	0.016	0.0135
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0151	0.0371	0.5686
Loa Loa (eye worm)	endoprotease bli-4	0.3147	1	1
Loa Loa (eye worm)	RNA binding protein	0.0047	0.0036	0.0011
Trichomonas vaginalis	conserved hypothetical protein	0.0682	0.2078	0.3673
Onchocerca volvulus		0.0058	0.0072	0.047
Toxoplasma gondii	PAN domain-containing protein	0.0323	0.0923	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0058	0.0072	0.0047
Brugia malayi	Trypsin family protein	0.0058	0.0072	0.0047

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	> 100 uM	Cytotoxicity towards the acute monocytic leukemia cell line (THP-1)	ChEMBL.	12127506
IC50 (functional)	> 100 uM	Cytotoxicity towards the acute monocytic leukemia cell line (THP-1)	ChEMBL.	12127506

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 103470