TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 538.099 | Formula: C26H36ClN3O5S
H donors: 5 H acceptors: 5 LogP: 2.69 Rotable bonds: 16
Rule of 5 violations (Lipinski): 2
SMILES: CSCC[C@@H](C(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C(C)C)NCc1ccccc1O.Cl
InChi: 1S/C26H35N3O5S.ClH/c1-17(2)23(27-16-19-11-7-8-12-22(19)30)25(32)29-21(15-18-9-5-4-6-10-18)24(31)28-20(26(33)34)13-14-35-3;/h4-12,17,20-21,23,27,30H,13-16H2,1-3H3,(H,28,31)(H,29,32)(H,33,34);1H/t20-,21-,23-;/m0./s1
InChiKey: KPTDLOVTDRIJPH-XCZLHMEYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Protein farnesyltransferase	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	protein farnesyltransferase subunit beta	Get druggable targets OG5_128081	All targets in OG5_128081
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Leishmania mexicana	farnesyltransferase beta subunit	Get druggable targets OG5_128081	All targets in OG5_128081
Neospora caninum	protein farnesyltranstransferase beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Trichomonas vaginalis	type I geranylgeranyltransferase beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Plasmodium vivax	conserved Plasmodium protein, unknown function	Get druggable targets OG5_128081	All targets in OG5_128081
Schistosoma japonicum	ko:K05954 farnesyltransferase, CAAX box, beta [EC:2.5.1.58], putative	Get druggable targets OG5_128081	All targets in OG5_128081
Plasmodium knowlesi	conserved Plasmodium protein, unknown function	Get druggable targets OG5_128081	All targets in OG5_128081
Echinococcus granulosus	protein farnesyltransferase subunit beta	Get druggable targets OG5_128081	All targets in OG5_128081
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	Get druggable targets OG5_128081	All targets in OG5_128081
Leishmania braziliensis	farnesyltransferase beta subunit	Get druggable targets OG5_128081	All targets in OG5_128081
Theileria parva	farnesyltransferase beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Leishmania major	farnesyltransferase beta subunit	Get druggable targets OG5_128081	All targets in OG5_128081
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	Get druggable targets OG5_128081	All targets in OG5_128081
Giardia lamblia	Prenyltransferase	Get druggable targets OG5_128081	All targets in OG5_128081
Cryptosporidium parvum	protein geranyl-geranyltransferase beta subunit	Get druggable targets OG5_128081	All targets in OG5_128081
Candida albicans	similar to S. cerevisiae RAM1 (YDL090C) beta subunit of farnesyl transferase (Ram1p+Ram2p), involved in prenylation of RAS prote	Get druggable targets OG5_128081	All targets in OG5_128081
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Plasmodium vivax	farnesyltransferase beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Leishmania infantum	farnesyltransferase beta subunit	Get druggable targets OG5_128081	All targets in OG5_128081
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	Get druggable targets OG5_128081	All targets in OG5_128081
Trypanosoma brucei	protein farnesyltransferase beta subunit	Get druggable targets OG5_128081	All targets in OG5_128081
Trypanosoma cruzi	protein farnesyltransferase, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Babesia bovis	prenyltransferase and squalene oxidase repeat family protein	Get druggable targets OG5_128081	All targets in OG5_128081
Plasmodium falciparum	protein farnesyltransferase subunit beta	Get druggable targets OG5_128081	All targets in OG5_128081
Trypanosoma cruzi	protein farnesyltransferase, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Entamoeba histolytica	protein farnesyltransferase beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Candida albicans	similar to S. cerevisiae RAM1 (YDL090C) beta subunit of farnesyl transferase (Ram1p+Ram2p), involved in prenylation of RAS prote	Get druggable targets OG5_128081	All targets in OG5_128081
Plasmodium berghei	protein farnesyltransferase subunit beta, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Trypanosoma brucei gambiense	protein farnesyltransferase beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Cryptosporidium hominis	chain B, structure of fpt bound to ggpp	Get druggable targets OG5_128081	All targets in OG5_128081
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Leishmania donovani	farnesyltransferase beta subunit	Get druggable targets OG5_128081	All targets in OG5_128081
Trichomonas vaginalis	geranylgeranyl transferase type beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Schistosoma mansoni	protein farnesyltransferase subunit beta	Get druggable targets OG5_128081	All targets in OG5_128081
Plasmodium yoelii	Prenyltransferase and squalene oxidase repeat, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Plasmodium knowlesi	protein farnesyltransferase subunit beta, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	protein farnesyltransferase beta subunit, putative	0.0018	0.0203	0.1767
Schistosoma mansoni	unc-13 (munc13)	0.005	0.0797	0.105
Echinococcus granulosus	snurportin 1	0.0324	0.599	0.5966
Trypanosoma cruzi	hypothetical protein, conserved	0.0025	0.0331	0.0173
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0131	0.1121
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0059	0.0976	0.1047
Trichomonas vaginalis	geranylgeranyl transferase type beta subunit, putative	0.0067	0.113	1
Trichomonas vaginalis	ran, putative	0.0022	0.0281	0.2456
Loa Loa (eye worm)	hypothetical protein	0.003	0.0433	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0331	0.0361
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0131	0.1121
Schistosoma mansoni	RAR-like nuclear receptor	0.0011	0.006	0.0078
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0131	0.1121
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0135	0.2408	0.3175
Onchocerca volvulus		0.0025	0.0331	0.2713
Echinococcus granulosus	protein prenyltransferase alpha subunit	0.0025	0.0331	0.0273
Schistosoma mansoni	ran	0.0022	0.0281	0.037
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0025	0.0331	0.0436
Schistosoma mansoni	hypothetical protein	0.0074	0.1258	0.1659
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0408	0.7584	1
Plasmodium vivax	importin-beta 2, putative	0.003	0.0433	0.0311
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0408	0.7584	1
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0408	0.7584	0.7569
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.0281	0.0105
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0043	0.0669	0.0631
Schistosoma mansoni	hypothetical protein	0.0034	0.0506	0.0667
Schistosoma mansoni	cpg binding protein	0.0067	0.1129	0.1488
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0131	0.1121
Plasmodium vivax	prenyltransferase alpha subunit, putative	0.0025	0.0331	0.0173
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0011	0.006	0.0078
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0408	0.7584	1
Trypanosoma brucei	lanosterol synthase	0.0074	0.1254	0.1424
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0016	0.0157	0.0098
Schistosoma mansoni	importin beta-1	0.003	0.0433	0.057
Trypanosoma cruzi	protein farnesyltransferase, putative	0.0067	0.113	0.1256
Echinococcus granulosus	cpg binding protein	0.0067	0.1129	0.1076
Brugia malayi	isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	0.005	0.0797	0.098
Echinococcus granulosus	geranylgeranyl transferase type I beta subunit	0.0018	0.0203	0.0145
Leishmania major	isocitrate dehydrogenase, putative	0.005	0.0797	0.0804
Trypanosoma brucei	protein kinase, putative	0.0059	0.0976	0.1047
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0064	0.106	0.133
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	0.0025	0.0331	0.0273
Schistosoma mansoni	hypothetical protein	0.0034	0.0506	0.0667
Loa Loa (eye worm)	isocitrate dehydrogenase gamma subunit	0.005	0.0797	0.098
Plasmodium falciparum	geranylgeranyltransferase, putative	0.0018	0.0203	0.0268
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0022	0.0281	0.0105
Echinococcus multilocularis	protein farnesyltransferase subunit beta	0.0067	0.113	0.1077
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0016	0.0157	0.0098
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0043	0.0669	0.0882
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0034	0.0506	0.0449
Schistosoma mansoni	geranylgeranyl transferase type I beta subunit	0.0018	0.0203	0.0268
Entamoeba histolytica	hypothetical protein	0.0025	0.0324	0.2866
Trypanosoma cruzi	lanosterol synthase, putative	0.0074	0.1254	0.1424
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0433	0.0311
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0011	0.006	0.0078
Brugia malayi	Probable isocitrate dehydrogenase	0.005	0.0797	0.098
Entamoeba histolytica	geranylgeranyl transferase beta subunit	0.0018	0.0203	0.1799
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	0.0067	0.113	0.1256
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0669	0.5905
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0203	0.0191
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0108	0.1906	0.2454
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0043	0.0669	0.0613
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0022	0.0281	0.037
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0059	0.0976	0.0922
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.002	0.023	0.0172
Echinococcus multilocularis	neuropeptide receptor A26	0.0536	1	1
Entamoeba histolytica	protein farnesyltransferase beta subunit, putative	0.0067	0.113	1
Plasmodium falciparum	protein farnesyltransferase subunit beta	0.0067	0.113	0.1491
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0067	0.113	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0034	0.0506	0.0594
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.0281	0.0105
Echinococcus multilocularis	geranylgeranyl transferase type 2 subunit alpha	0.0025	0.0331	0.0273
Schistosoma mansoni	serine/threonine protein kinase	0.0059	0.0976	0.1287
Schistosoma mansoni	geranylgeranyl transferase type II beta subunit	0.0018	0.0203	0.0268
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0408	0.7584	1
Entamoeba histolytica	Rab geranylgeranyltransferase beta subunit, putative	0.0018	0.0203	0.1799
Echinococcus multilocularis	snurportin 1	0.0324	0.599	0.5966
Leishmania major	GTP-binding protein, putative	0.0022	0.0281	0.0105
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	0.0018	0.0203	0.0191
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.006	0.0078
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0131	0.1121
Echinococcus multilocularis	importin subunit beta 1	0.003	0.0433	0.0375
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0043	0.0669	0.5026
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0408	0.7584	1
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.0025	0.0331	0.0173
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0043	0.0669	0.0631
Toxoplasma gondii	isocitrate dehydrogenase	0.0408	0.7584	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.0797	0.098
Brugia malayi	RNA, U transporter 1	0.0086	0.1491	0.1903
Onchocerca volvulus		0.0064	0.106	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0016	0.0157	0.0098
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.0018	0.0203	0.0191
Trichomonas vaginalis	CMGC family protein kinase	0.0059	0.0976	0.8627
Echinococcus multilocularis	isocitrate dehydrogenase (NAD+)	0.005	0.0797	0.0741
Echinococcus multilocularis	cpg binding protein	0.0067	0.1129	0.1076
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	0.0018	0.0203	0.1767
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1258	0.1593
Mycobacterium tuberculosis	Halimadienyl diphosphate synthase	0.0074	0.1254	0.0674
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0408	0.7584	1
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.006	0.0078
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0011	0.006	0.0078
Entamoeba histolytica	Rab geranylgeranyltransferase alpha subunit, putative	0.0025	0.0331	0.2928
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0408	0.7584	0.7569
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0059	0.0976	0.1218
Brugia malayi	Importin beta-1 subunit	0.003	0.0433	0.0496
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0433	0.0311
Echinococcus granulosus	protein farnesyltransferase alpha subunit	0.0025	0.0331	0.0273
Brugia malayi	Latrophilin receptor protein 2	0.0034	0.0506	0.0594
Echinococcus multilocularis	protein prenyltransferase alpha subunit	0.0025	0.0331	0.0273
Echinococcus granulosus	GPCR family 2	0.0034	0.0506	0.0449
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0022	0.0281	0.0223
Echinococcus granulosus	isocitrate dehydrogenase NAD	0.005	0.0797	0.0741
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0043	0.0669	0.5905
Echinococcus multilocularis	isocitrate dehydrogenase (NAD) subunit	0.005	0.0797	0.0741
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0022	0.0281	0.0105
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0009	0.0031	0.004
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0059	0.0976	0.1047
Mycobacterium ulcerans	3-isopropylmalate dehydrogenase	0.005	0.0797	0.5
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0014	0.0131	0.1121
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0043	0.0669	0.0613
Trichomonas vaginalis	CMGC family protein kinase	0.0059	0.0976	0.8627
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0067	0.113	1
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0025	0.0331	0.0361
Leishmania major	farnesyltransferase beta subunit	0.0067	0.113	0.1256
Giardia lamblia	Rab geranylgeranyltransferase	0.0025	0.0331	0.1377
Echinococcus granulosus	mitogen activated protein kinase	0.0059	0.0976	0.0922
Leishmania major	importin beta-1 subunit, putative	0.0025	0.0324	0.0163
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0408	0.7584	0.7569
Schistosoma mansoni	hypothetical protein	0.0172	0.3102	0.4091
Echinococcus multilocularis	isocitrate dehydrogenase	0.0408	0.7584	0.7569
Echinococcus granulosus	importin subunit beta 1	0.003	0.0433	0.0375
Trichomonas vaginalis	protein farnesyltransferase beta subunit, putative	0.0018	0.0203	0.1767
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.0025	0.0331	0.0173
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0034	0.0506	0.0449
Schistosoma mansoni	cpg binding protein	0.0064	0.106	0.1398
Brugia malayi	Isocitrate dehydrogenase	0.0408	0.7584	1
Echinococcus multilocularis	Rab geranylgeranyltransferase, beta subunit	0.0018	0.0203	0.0145
Leishmania major	protein farnesyltransferase alpha subunit, putative	0.0025	0.0331	0.0173
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	0.0067	0.113	0.1423
Brugia malayi	isocitrate dehydrogenase	0.0408	0.7584	1
Schistosoma mansoni	protein farnesyltransferase alpha subunit	0.0025	0.0331	0.0436
Brugia malayi	isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	0.005	0.0797	0.098
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0059	0.0976	0.1047
Wolbachia endosymbiont of Brugia malayi	isocitrate dehydrogenase	0.005	0.0797	0.5
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0131	0.1121
Plasmodium vivax	protein prenyltransferase alpha subunit, putative	0.0025	0.0331	0.0173
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0034	0.0506	0.0594
Trichomonas vaginalis	CMGC family protein kinase	0.0059	0.0976	0.8627
Schistosoma mansoni	retinoic acid receptor RXR	0.0011	0.006	0.0078
Toxoplasma gondii	histone lysine methyltransferase SET1	0.012	0.2135	0.2618
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0043	0.0669	0.5905
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1906	0.2454
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0203	0.0191
Loa Loa (eye worm)	histone methyltransferase	0.002	0.023	0.0227
Schistosoma mansoni	Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial	0.005	0.0797	0.105
Schistosoma mansoni	hypothetical protein	0.0172	0.3102	0.4091
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0043	0.0669	0.0631
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0043	0.0669	0.081
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0011	0.006	0.0078
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0043	0.0669	0.0882
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0059	0.0976	0.1047
Schistosoma mansoni	cpg binding protein	0.0067	0.1129	0.1488
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0011	0.006	0.0078
Giardia lamblia	Kinase, CMGC MAPK	0.0059	0.0976	0.8332
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0025	0.0331	0.0361
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0025	0.0324	0.0163
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0025	0.0331	0.2901
Plasmodium falciparum	geranylgeranyl transferase type-2 subunit alpha, putative	0.0025	0.0331	0.0436
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0324	0.2838
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0025	0.0331	0.2901
Trypanosoma cruzi	protein farnesyltransferase, putative	0.0067	0.113	0.1256
Echinococcus granulosus	neuropeptide receptor A26	0.0536	1	1
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0043	0.0669	0.0631
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0324	0.2838
Echinococcus multilocularis	mitogen activated protein kinase	0.0059	0.0976	0.0922
Trypanosoma cruzi	Protein prenyltransferase alpha subunit repeat, putative	0.0025	0.0331	0.0173
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0131	0.1121
Trypanosoma brucei	hypothetical protein, conserved	0.0025	0.0331	0.0173
Schistosoma mansoni	hypothetical protein	0.0324	0.599	0.7898
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0011	0.006	0.0078
Brugia malayi	F/Y-rich N-terminus family protein	0.0019	0.0225	0.022
Toxoplasma gondii	hypothetical protein	0.0025	0.0331	0.0173
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0108	0.1906	0.2454
Mycobacterium leprae	PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH)	0.005	0.0797	0.5
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0025	0.0331	0.0361
Brugia malayi	Probable isocitrate dehydrogenase	0.005	0.0797	0.098
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0131	0.1121
Trypanosoma brucei	protein farnesyltransferase beta subunit	0.0067	0.113	0.1256
Brugia malayi	CXXC zinc finger family protein	0.0064	0.106	0.133
Echinococcus multilocularis	ubiquitin specific protease 41	0.0043	0.0669	0.0613
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.0025	0.0331	0.0173
Toxoplasma gondii	isocitrate dehydrogenase	0.0408	0.7584	1
Brugia malayi	Isocitrate dehydrogenase subunit gamma, mitochondrial precursor	0.005	0.0797	0.098
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0669	0.081
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0043	0.0669	0.0613
Echinococcus granulosus	geminin	0.0172	0.3102	0.3061
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0022	0.0281	0.0294
Brugia malayi	Probable protein farnesyltransferase beta subunit, putative	0.0018	0.0203	0.0191
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0034	0.0506	0.0449
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0016	0.0157	0.0207
Plasmodium falciparum	protein farnesyltransferase subunit alpha	0.0025	0.0331	0.0436
Schistosoma mansoni	isocitrate dehydrogenase	0.005	0.0797	0.105
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0043	0.0669	0.0613
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0408	0.7584	1
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0016	0.0157	0.0098
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	0.0025	0.0331	0.2928
Echinococcus multilocularis	neuropeptide s receptor	0.0536	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0131	0.1121
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0049	0.0785	0.0789
Plasmodium falciparum	geranylgeranyl transferase type2 beta subunit, putative	0.0018	0.0203	0.0268
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0408	0.7584	1
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0408	0.7584	0.7569
Schistosoma mansoni	coup transcription factor	0.0011	0.006	0.0078
Giardia lamblia	Prenyltransferase	0.0067	0.113	1
Schistosoma mansoni	hypothetical protein	0.0034	0.0506	0.0667
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.0067	0.113	0.1423
Trichomonas vaginalis	importin beta-1, putative	0.0025	0.0324	0.2838
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0022	0.0281	0.0837
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0408	0.7584	1
Echinococcus granulosus	geranylgeranyl transferase type 2 subunit alpha	0.0025	0.0331	0.0273
Entamoeba histolytica	tartrate dehydrogenase, putative	0.005	0.0797	0.7047
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0034	0.0506	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0506	0.0594
Schistosoma mansoni	geranylgeranyl transferase type I beta subunit	0.0018	0.0203	0.0268
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.006	0.0078
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0059	0.0976	0.1047
Trypanosoma cruzi	hypothetical protein, conserved	0.0025	0.0331	0.0173
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0022	0.0281	0.0105
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0324	0.599	0.7882
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.006	0.0078
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0025	0.0331	0.2901
Echinococcus granulosus	ubiquitin specific protease 41	0.0043	0.0669	0.0613
Trichomonas vaginalis	type I geranylgeranyltransferase beta subunit, putative	0.0067	0.113	1
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0131	0.1121
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0022	0.0281	0.0294
Schistosoma mansoni	protein farnesyltransferase subunit beta	0.0067	0.113	0.1491
Entamoeba histolytica	Ran family GTPase	0.0022	0.0281	0.2485
Toxoplasma gondii	HEAT repeat-containing protein	0.003	0.0433	0.0311
Brugia malayi	MAP kinase sur-1	0.0059	0.0976	0.1218
Trichomonas vaginalis	helicase, putative	0.0014	0.0131	0.1121
Trypanosoma brucei	protein farnesyltransferase alpha subunit, putative	0.0025	0.0331	0.0173
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0408	0.7584	0.7569
Echinococcus granulosus	mitogen activated protein kinase 3	0.0059	0.0976	0.0922
Plasmodium vivax	farnesyltransferase beta subunit, putative	0.0067	0.113	0.1256
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0022	0.0281	0.0223
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0131	0.1121
Trichomonas vaginalis	isocitrate dehydrogenase, putative	0.005	0.0797	0.7035
Echinococcus granulosus	protein farnesyltransferase subunit beta	0.0067	0.113	0.1077
Trypanosoma cruzi	lanosterol synthase, putative	0.0074	0.1254	0.1424
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0059	0.0976	0.1047
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0014	0.0131	0.1121
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0408	0.7584	1
Schistosoma mansoni	ran	0.0022	0.0281	0.037
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0059	0.0976	0.1047
Echinococcus multilocularis	geranylgeranyl transferase type I beta subunit	0.0018	0.0203	0.0145
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0067	0.113	1
Echinococcus multilocularis	geminin	0.0172	0.3102	0.3061
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0043	0.0669	0.592
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0131	0.1121
Schistosoma mansoni	hypothetical protein	0.0034	0.0506	0.0667
Trichomonas vaginalis	CMGC family protein kinase	0.0059	0.0976	0.8627
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.0025	0.0331	0.0173
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	0.0067	0.113	1
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0025	0.0331	0.0361
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0025	0.0331	0.2901
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0131	0.1121
Leishmania major	lanosterol synthase, putative	0.0056	0.0909	0.0956
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.002	0.023	0.0172
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0108	0.1906	0.2454
Brugia malayi	latrophilin 2 splice variant baaae	0.0074	0.1258	0.1593
Echinococcus multilocularis	GPCR, family 2	0.0034	0.0506	0.0449
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0131	0.1121
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0131	0.1121
Giardia lamblia	Rab geranylgeranyltransferase	0.0025	0.0331	0.1377
Plasmodium falciparum	importin beta, putative	0.003	0.0433	0.057
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0059	0.0976	0.1047
Echinococcus granulosus	isocitrate dehydrogenase NAD subunit	0.005	0.0797	0.0741

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 2.4 uM	Inhibition of farnesyl transferase	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL542198

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1034757