Detailed information for compound 1035290

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 441.57 | Formula: C15H14Cl5N5
  • H donors: 3 H acceptors: 0 LogP: 5.52 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: N=C(NC(=N)Nc1ccc(c(c1)Cl)Cl)NCc1ccc(c(c1)Cl)Cl.Cl
  • InChi: 1S/C15H13Cl4N5.ClH/c16-10-3-1-8(5-12(10)18)7-22-14(20)24-15(21)23-9-2-4-11(17)13(19)6-9;/h1-6H,7H2,(H5,20,21,22,23,24);1H
  • InChiKey: LBYRCCYEFSHXBR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0035 0.0046 0.0026
Leishmania major hypothetical protein, conserved 0.008 0.0141 0.0141
Mycobacterium ulcerans hydrolase MutT1 0.008 0.0141 0.024
Schistosoma mansoni coup transcription factor 0.0027 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0027 0.0029 0.0027
Schistosoma mansoni ap endonuclease 0.0019 0.0013 0.0013
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0047 0.0878
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0027 0.0029 0.0029
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0022 0.002 0.002
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0304 0.0614 0.0612
Leishmania major importin beta-1 subunit, putative 0.0023 0.0021 0.0021
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0046 0.0755
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.004 0.004
Echinococcus granulosus para nitrobenzyl esterase 0.0022 0.002 0.002
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0054 0.0054
Schistosoma mansoni thyroid hormone receptor 0.0027 0.0029 0.0029
Onchocerca volvulus 0.0035 0.0046 0.0026
Plasmodium vivax SET domain protein, putative 0.0034 0.0044 0.3093
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0027 0.0029 0.0139
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0027 0.0029 0.0139
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0013 0.0241
Brugia malayi Glycosyl hydrolases family 31 protein 0.0159 0.0309 0.1473
Echinococcus granulosus phosphoglycerate mutase 0.008 0.0141 0.0141
Loa Loa (eye worm) steroid hormone receptor 0.0027 0.0029 0.0027
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0101 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0035 0.0046 0.0044
Schistosoma mansoni hypothetical protein 0.008 0.0141 0.0141
Mycobacterium tuberculosis Conserved hypothetical protein 0.008 0.0141 0.2331
Echinococcus multilocularis snurportin 1 0.0304 0.0614 0.0614
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0027 0.0029 0.0029
Echinococcus granulosus phosphoglycerate mutase 0.008 0.0141 0.0141
Entamoeba histolytica phosphoglycerate mutase family protein. putative 0.008 0.0141 0.0219
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0013 0.0013
Loa Loa (eye worm) glutathione reductase 0.0038 0.0053 0.0051
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0032 0.0032
Echinococcus granulosus FTZ F1 alpha 0.0027 0.0029 0.0029
Brugia malayi Carboxylesterase family protein 0.0022 0.002 0.0093
Brugia malayi Latrophilin receptor protein 2 0.0065 0.011 0.0526
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0013 0.0022
Schistosoma mansoni hypothetical protein 0.0035 0.0046 0.0046
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.008 0.0141 0.0141
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0047 0.0878
Schistosoma mansoni hypothetical protein 0.0028 0.0032 0.0032
Trypanosoma cruzi phosphoglycerate mutase, putative 0.008 0.0141 0.0141
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0235 0.0469 0.0469
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.008 0.0141 0.0141
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0027 0.0029 0.001
Brugia malayi ecdysteroid receptor 0.0027 0.0029 0.0139
Leishmania major hypothetical protein, conserved 0.0028 0.003 0.003
Plasmodium falciparum thioredoxin reductase 0.0038 0.0053 0.3742
Echinococcus multilocularis FTZ F1 alpha 0.0027 0.0029 0.0029
Onchocerca volvulus 0.4743 1 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.011 0.011
Mycobacterium ulcerans beta-lactamase 0.0035 0.0046 0.0078
Loa Loa (eye worm) carboxylesterase 0.0022 0.002 0.0017
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0029 0.0029
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.008 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0017
Loa Loa (eye worm) hypothetical protein 0.008 0.0141 0.0139
Leishmania major hypothetical protein, conserved 0.0035 0.0046 0.0046
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0046 0.0046
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0048 0.0048
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0087 0.0156 0.8432
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0013 0.0211
Echinococcus granulosus BC026374 protein S09 family 0.0022 0.002 0.002
Echinococcus multilocularis serine:threonine protein phosphatase PGAM5 0.008 0.0141 0.0141
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0034 0.0032
Mycobacterium ulcerans bifunctional RNase H/acid phosphatase 0.008 0.0141 0.024
Toxoplasma gondii phosphoglycerate mutase 0.008 0.0141 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0141 0.0139
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0047 0.0047
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.003 0.003
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.003 0.2135
Leishmania major phosphoglycerate mutase, putative 0.008 0.0141 0.0141
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0133 0.0253 0.0253
Mycobacterium tuberculosis Conserved protein 0.008 0.0141 0.2331
Mycobacterium leprae conserved hypothetical protein 0.008 0.0141 0.7274
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.001 0.001
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0044 0.0044
Plasmodium falciparum phosphoglucomutase-2 0.008 0.0141 1
Onchocerca volvulus 0.0035 0.0046 0.0026
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0032 0.0032
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0022 0.002 0.0322
Trypanosoma cruzi phosphoglycerate mutase, putative 0.008 0.0141 0.0141
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0141 0.2657
Loa Loa (eye worm) hypothetical protein 0.0035 0.0046 0.0044
Leishmania major hypothetical protein, conserved 0.008 0.0141 0.0141
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0047 0.0878
Trichomonas vaginalis phosphoglycerate mutase, putative 0.008 0.0141 0.2657
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0141 0.2657
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0044 0.3093
Echinococcus granulosus geminin 0.1022 0.2132 0.2132
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0046 0.0044
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.008 0.0141 0.0141
Schistosoma mansoni hypothetical protein 0.0065 0.011 0.011
Brugia malayi hypothetical protein 0.0028 0.003 0.0144
Echinococcus multilocularis cpg binding protein 0.0031 0.0038 0.0038
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0224 0.0446 0.0444
Schistosoma mansoni cpg binding protein 0.0031 0.0038 0.0038
Mycobacterium tuberculosis Probable dehydrogenase 0.0087 0.0156 0.2582
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0046 0.086
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0027 0.0029 0.0139
Plasmodium vivax phosphoglycerate mutase, putative 0.008 0.0141 1
Mycobacterium ulcerans lipase LipD 0.0035 0.0046 0.0078
Schistosoma mansoni hypothetical protein 0.042 0.086 0.086
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.011 0.0526
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0047 0.0878
Mycobacterium ulcerans fructose-2,6-bisphosphatase GpmB 0.2799 0.589 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0047 0.0878
Mycobacterium ulcerans acid phosphatase 0.008 0.0141 0.024
Brugia malayi hypothetical protein 0.0293 0.0592 0.2826
Echinococcus multilocularis acetylcholinesterase 0.0133 0.0253 0.0253
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0046 0.0046
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0235 0.0469 0.0469
Plasmodium falciparum phd finger protein, putative 0.0028 0.0032 0.2244
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0235 0.0469 0.0467
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0047 0.0058
Echinococcus multilocularis BC026374 protein (S09 family) 0.0022 0.002 0.002
Schistosoma mansoni hypothetical protein 0.008 0.0141 0.0141
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0022 0.002 0.002
Trypanosoma brucei trypanothione reductase 0.0038 0.0053 0.0053
Brugia malayi follicle stimulating hormone receptor 0.0224 0.0446 0.2131
Toxoplasma gondii phosphoglycerate mutase family protein 0.008 0.0141 1
Echinococcus multilocularis dnaJ subfamily B 0.042 0.086 0.086
Echinococcus granulosus carboxylesterase 5A 0.0133 0.0253 0.0253
Echinococcus granulosus serine:threonine protein phosphatase PGAM5 0.008 0.0141 0.0141
Schistosoma mansoni BC026374 protein (S09 family) 0.0022 0.002 0.002
Echinococcus multilocularis phosphoglycerate mutase 0.008 0.0141 0.0141
Echinococcus granulosus fatty acid amide hydrolase 1 0.0101 0.0186 0.0186
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0027 0.0029 0.0029
Mycobacterium ulcerans phosphoglycerate mutase 0.008 0.0141 0.024
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0235 0.0469 0.0469
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0013 0.0241
Echinococcus granulosus GPCR family 2 0.0065 0.011 0.011
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0027 0.0029 0.0139
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0013 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0027 0.0029 0.0139
Brugia malayi nuclear receptor RXR 0.0014 0.0002 0.001
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.2024 0.4251 0.4251
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.4663 0.9831 0.9831
Loa Loa (eye worm) hypothetical protein 0.0133 0.0253 0.0251
Brugia malayi nuclear hormone receptor 0.0027 0.0029 0.0139
Echinococcus multilocularis 6 phosphofructo 2 kinase:fructose 2 0.4743 1 1
Leishmania major hypothetical protein, conserved 0.008 0.0141 0.0141
Echinococcus granulosus dnaJ subfamily B 0.042 0.086 0.086
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0047 0.0047
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0048 0.0048
Toxoplasma gondii exonuclease III APE 0.0019 0.0013 0.0907
Brugia malayi nuclear receptor NHR-88 0.0027 0.0029 0.0139
Mycobacterium ulcerans short chain dehydrogenase 0.03 0.0606 0.1029
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0027 0.0029 0.0029
Schistosoma mansoni acetylcholinesterase 0.0022 0.002 0.002
Brugia malayi hypothetical protein 0.0022 0.002 0.0093
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0046 0.0755
Brugia malayi hypothetical protein 0.0035 0.0046 0.0218
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0027 0.0029 0.0139
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0047 0.0878
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0027 0.0029 0.0029
Brugia malayi Pre-SET motif family protein 0.0034 0.0044 0.0209
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0013 0.0013
Brugia malayi Carboxylesterase family protein 0.0022 0.002 0.0093
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0046 0.086
Loa Loa (eye worm) hypothetical protein 0.008 0.0141 0.0139
Schistosoma mansoni steroid hormone receptor ad4bp 0.0027 0.0029 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0027 0.0029 0.0027
Loa Loa (eye worm) hypothetical protein 0.4743 1 1
Schistosoma mansoni hypothetical protein 0.0065 0.011 0.011
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0029 0.0029
Schistosoma mansoni hypothetical protein 0.008 0.0141 0.0141
Mycobacterium tuberculosis Probable oxidoreductase 0.0097 0.0177 0.2922
Loa Loa (eye worm) hypothetical protein 0.0027 0.0029 0.0027
Trichomonas vaginalis phosphoglycerate mutase, putative 0.008 0.0141 0.2657
Giardia lamblia Hypothetical protein 0.2799 0.589 1
Echinococcus granulosus peregrin 0.0028 0.0032 0.0032
Echinococcus multilocularis phosphoglycerate mutase 0.008 0.0141 0.0141
Treponema pallidum phosphoglyceromutase 0.008 0.0141 1
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0013 0.0063
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0047 0.0878
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0017
Loa Loa (eye worm) hypothetical protein 0.0035 0.0046 0.0044
Schistosoma mansoni alpha-glucosidase 0.0137 0.0262 0.0262
Echinococcus multilocularis neuroligin 0.0022 0.002 0.002
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0047 0.0047
Brugia malayi beta-lactamase family protein 0.0035 0.0046 0.0218
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0032 0.2274
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0046 0.0755
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0027 0.0029 0.0027
Echinococcus multilocularis para nitrobenzyl esterase 0.0022 0.002 0.002
Schistosoma mansoni cpg binding protein 0.0029 0.0034 0.0034
Entamoeba histolytica hypothetical protein 0.0023 0.0021 0.0013
Onchocerca volvulus 0.0029 0.0034 0.0015
Echinococcus granulosus acetylcholinesterase 0.0133 0.0253 0.0253
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.011 0.011
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0235 0.0469 0.0469
Brugia malayi hydrolase, alpha/beta fold family protein 0.1004 0.2095 1
Onchocerca volvulus Protein UBASH3A homolog 0.008 0.0141 0.0122
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0055 0.0055
Onchocerca volvulus 0.008 0.0141 0.0122
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0027 0.0029 0.0029
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.4743 1 1
Trypanosoma cruzi phosphoglycerate mutase protein, putative 0.008 0.0141 0.0141
Onchocerca volvulus 0.008 0.0141 0.0122
Mycobacterium ulcerans hypothetical protein 0.008 0.0141 0.024
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0087 0.0156 0.2582
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0013 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0097 0.0177 0.2922
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0027 0.0029 0.0027
Leishmania major phosphoglycerate mutase family member 5, putative 0.008 0.0141 0.0141
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.2024 0.4251 0.4251
Brugia malayi PHD-finger family protein 0.0028 0.0032 0.0151
Schistosoma mansoni neuroligin 3 (S09 family) 0.0022 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0027 0.0029 0.0027
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.4663 0.9831 0.9831
Loa Loa (eye worm) hydrolase 0.2023 0.4249 0.4247
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0053 0.0872
Echinococcus granulosus neuroligin 0.0022 0.002 0.002
Schistosoma mansoni hypothetical protein 0.008 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0133 0.0253 0.0251
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0046 0.0046
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0044 0.0044
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0207 0.0409 0.0407
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0046 0.0046
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0235 0.0469 0.0469
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0027 0.0029 0.0139
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.4663 0.9831 0.9831
Echinococcus multilocularis carboxylesterase 5A 0.0133 0.0253 0.0253
Brugia malayi Pre-SET motif family protein 0.0233 0.0464 0.2214
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0013 0.0061
Brugia malayi RNA, U transporter 1 0.0081 0.0143 0.0683
Mycobacterium tuberculosis Probable oxidoreductase 0.03 0.0606 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.0309 0.0309
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0032 0.0032
Echinococcus granulosus phosphoglycerate mutase 0.008 0.0141 0.0141
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein 0.2024 0.4251 0.4251
Brugia malayi glutathione reductase 0.0038 0.0053 0.0252
Loa Loa (eye worm) acetylcholinesterase 1 0.0133 0.0253 0.0251
Entamoeba histolytica hypothetical protein 0.0035 0.0046 0.0056
Brugia malayi phosphoglycerate mutase family protein 0.008 0.0141 0.0674
Loa Loa (eye worm) hypothetical protein 0.0027 0.0029 0.0027
Brugia malayi beta-lactamase family protein 0.0035 0.0046 0.0218
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0021 0.039
Brugia malayi CXXC zinc finger family protein 0.0029 0.0034 0.0164
Mycobacterium leprae conserved hypothetical protein 0.008 0.0141 0.7274
Trypanosoma brucei phosphoglycerate mutase protein, putative 0.008 0.0141 0.0141
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0027 0.0029 0.0029
Mycobacterium ulcerans lipoprotein LpqD 0.008 0.0141 0.024
Entamoeba histolytica hypothetical protein 0.0035 0.0046 0.0056
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.0443 0.7314
Echinococcus granulosus phosphoglycerate mutase 0.008 0.0141 0.0141
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0046 0.086
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0027 0.0029 0.0027
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.2024 0.4251 0.4251
Schistosoma mansoni hypothetical protein 0.0141 0.0271 0.0271
Schistosoma mansoni hypothetical protein 0.1022 0.2132 0.2132
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0046 0.0755
Toxoplasma gondii thioredoxin reductase 0.0038 0.0053 0.3742
Onchocerca volvulus Protein UBASH3A homolog 0.008 0.0141 0.0122
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0029 0.0029
Giardia lamblia Hypothetical protein 0.2799 0.589 1
Brugia malayi UBASH3A protein homolog 0.008 0.0141 0.0674
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0021 0.0021
Echinococcus multilocularis thyroid hormone receptor alpha 0.0027 0.0029 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0027 0.0029 0.0027
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0207 0.0409 0.1952
Mycobacterium tuberculosis Possible hydrolase MutT1 0.008 0.0141 0.2331
Loa Loa (eye worm) hypothetical protein 0.0027 0.0029 0.0027
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0093 0.6562
Trypanosoma brucei Serine/threonine-protein phosphatase PGAM5, mitochondrial, putative 0.008 0.0141 0.0141
Schistosoma mansoni jumonji domain containing protein 0.0073 0.0127 0.0127
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0046 0.0046
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0047 0.0044
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0021 0.039
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0221 0.0219
Brugia malayi beta-lactamase 0.0035 0.0046 0.0218
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0047 0.0878
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0027 0.0029 0.0029
Trichomonas vaginalis spcc417.12 protein, putative 0.0022 0.002 0.0367
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0027 0.0029 0.0029
Mycobacterium tuberculosis Probable reductase 0.0087 0.0156 0.2582
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0221 0.0219
Brugia malayi photoreceptor-specific nuclear receptor 0.0027 0.0029 0.0139
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0046 0.0078
Plasmodium vivax importin-beta 2, putative 0.0028 0.0032 0.2274
Echinococcus multilocularis phosphoglycerate mutase 0.008 0.0141 0.0141
Onchocerca volvulus 0.0034 0.0044 0.0024
Schistosoma mansoni ap endonuclease 0.0019 0.0013 0.0013
Plasmodium falciparum phosphoglycerate mutase, putative 0.008 0.0141 1
Trypanosoma brucei 6-phosphofructo-2-kinase 2 0.4663 0.9831 0.9831
Echinococcus multilocularis serine:threonine protein phosphatase PGAM5 0.008 0.0141 0.0141
Echinococcus granulosus phosphoglycerate mutase 0.008 0.0141 0.0141
Leishmania major hypothetical protein, unknown function 0.008 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0035 0.0046 0.0044
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0055 0.0055
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0027 0.0029 0.0027
Onchocerca volvulus 0.0265 0.0532 0.0513
Loa Loa (eye worm) hypothetical protein 0.0048 0.0074 0.0072
Schistosoma mansoni amidase 0.0101 0.0186 0.0186
Schistosoma mansoni RAR-like nuclear receptor 0.0027 0.0029 0.0029
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0014 0.0002 0.0002
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0029 0.0139
Trypanosoma cruzi phosphoglycerate mutase protein, putative 0.008 0.0141 0.0141
Schistosoma mansoni phosphoglycerate mutase 0.008 0.0141 0.0141
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.4743 1 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0097 0.0177 1
Mycobacterium leprae Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) 0.008 0.0141 0.7274
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0235 0.0469 0.0469
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0044 0.0044
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.4743 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.0029 0.0139
Mycobacterium leprae PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM) 0.008 0.0141 0.7274
Trypanosoma brucei phosphoglycerate mutase, putative 0.008 0.0141 0.0141
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.0002 0.001
Loa Loa (eye worm) hypothetical protein 0.0034 0.0044 0.0042
Schistosoma mansoni cpg binding protein 0.0031 0.0038 0.0038
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.008 0.0141 0.0219
Loa Loa (eye worm) hypothetical protein 0.0028 0.0032 0.003
Onchocerca volvulus 0.0293 0.0592 0.0574
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.008 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0017
Loa Loa (eye worm) hypothetical protein 0.0141 0.0271 0.0269
Brugia malayi Importin beta-1 subunit 0.0028 0.0032 0.0153
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0014 0.0002 0.0002
Brugia malayi Bromodomain containing protein 0.0028 0.0032 0.0151
Schistosoma mansoni thyroid hormone receptor 0.0027 0.0029 0.0029
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0013 0.0013
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0047 0.3303
Echinococcus multilocularis peregrin 0.0028 0.0032 0.0032
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0013 0.0013
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0029 0.0029
Echinococcus multilocularis acetylcholinesterase 0.0133 0.0253 0.0253
Schistosoma mansoni fatty-acid amide hydrolase 0.0101 0.0186 0.0186
Echinococcus granulosus snurportin 1 0.0304 0.0614 0.0614
Echinococcus multilocularis GPCR, family 2 0.0065 0.011 0.011
Onchocerca volvulus Bile acid receptor homolog 0.0027 0.0029 0.001
Schistosoma mansoni alpha glucosidase 0.0035 0.0047 0.0047
Loa Loa (eye worm) carboxylesterase 0.0133 0.0253 0.0251
Brugia malayi latrophilin 2 splice variant baaae 0.0141 0.0271 0.1292
Loa Loa (eye worm) beta-lactamase 0.0035 0.0046 0.0044
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0032 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.0029 0.0139
Loa Loa (eye worm) hypothetical protein 0.0035 0.0046 0.0044
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.011 0.011
Trypanosoma cruzi glycerolphosphate mutase, putative 0.008 0.0141 0.0141
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.008 0.0141 0.0219
Trichomonas vaginalis phosphoglycerate mutase, putative 0.008 0.0141 0.2657
Leishmania major glycerolphosphate mutase, putative 0.008 0.0141 0.0141
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.008 0.0141 0.0141
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0048 0.0046
Loa Loa (eye worm) hypothetical protein 0.4663 0.9831 0.9831
Mycobacterium tuberculosis PE-PGRS family protein PE_PGRS11 0.008 0.0141 0.2331
Mycobacterium ulcerans carboxylesterase, LipT 0.0022 0.002 0.0033
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0097 0.0177 0.2922
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0027 0.0029 0.0029
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0107 0.0107
Plasmodium falciparum glutathione reductase 0.0038 0.0053 0.3742
Toxoplasma gondii phosphoglycerate mutase family protein 0.008 0.0141 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0013 0.0013
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0053 0.3742
Loa Loa (eye worm) hypothetical protein 0.0027 0.0029 0.0027
Trypanosoma cruzi glycerolphosphate mutase, putative 0.008 0.0141 0.0141
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.0029 0.0139
Loa Loa (eye worm) hypothetical protein 0.0293 0.0592 0.059
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0053 0.0051
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.0002 0.001
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0014 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0017
Brugia malayi Carboxylesterase family protein 0.0022 0.002 0.0093
Echinococcus multilocularis ecdysone induced protein 78C 0.0027 0.0029 0.0029
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0044 0.0044
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0022 0.002 0.002
Entamoeba histolytica hypothetical protein 0.0035 0.0046 0.0056
Leishmania major fructose-6-phosphate2-kinase/fructose-2,6-bisph os phatase-likeprotein 0.008 0.0141 0.0141
Brugia malayi hypothetical protein 0.0014 0.0002 0.001
Trichomonas vaginalis set domain proteins, putative 0.0265 0.0532 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.003 0.003
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0032 0.003
Brugia malayi phosphoglycerate mutase family protein 0.008 0.0141 0.0674
Mycobacterium ulcerans hypothetical protein 0.2799 0.589 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0159 0.0309 0.0309
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0207 0.0409 0.0407
Mycobacterium tuberculosis Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) 0.008 0.0141 0.2331
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0017
Brugia malayi MH2 domain containing protein 0.0118 0.0221 0.1055
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0101 0.0186 0.0186
Trichomonas vaginalis phosphoglycerate mutase, putative 0.008 0.0141 0.2657
Brugia malayi hypothetical protein 0.0119 0.0223 0.1064
Loa Loa (eye worm) hypothetical protein 0.0028 0.0032 0.003
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.008 0.0141 0.0141
Mycobacterium tuberculosis Probable conserved lipoprotein LpqD 0.008 0.0141 0.2331
Echinococcus granulosus acetylcholinesterase 0.0133 0.0253 0.0253
Leishmania major trypanothione reductase 0.0038 0.0053 0.0053
Mycobacterium leprae probable isochorismate synthase EntC 0.008 0.0141 0.7274
Loa Loa (eye worm) carboxylesterase 0.0022 0.002 0.0017
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0032 0.2244
Trypanosoma brucei glucosidase, putative 0.0035 0.0047 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.0029 0.0139
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0017
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0048 0.0048
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0046 0.0218
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0046 0.3237
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0032 0.0032
Chlamydia trachomatis 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 0.008 0.0141 1
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative 0.008 0.0141 0.0141
Entamoeba histolytica hypothetical protein 0.0035 0.0046 0.0056
Plasmodium vivax glutathione reductase, putative 0.0038 0.0053 0.3742
Mycobacterium tuberculosis Carboxylesterase LipT 0.0022 0.002 0.0322
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.008 0.0141 0.0141
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.003 0.2135
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.0029 0.0139
Plasmodium vivax phosphoglucomutase-2, putative 0.008 0.0141 1
Echinococcus granulosus ecdysone induced protein 78C 0.0027 0.0029 0.0029
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.011 0.0108
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0047 0.0878
Schistosoma mansoni hypothetical protein 0.0065 0.011 0.011
Echinococcus granulosus fatty acid amide hydrolase 1 0.0101 0.0186 0.0186
Mycobacterium ulcerans phosphoglyceromutase 0.008 0.0141 0.024
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.08 0.1663 0.1663
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0233 0.0464 0.0462
Brugia malayi Carboxylesterase family protein 0.0133 0.0253 0.121
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0046 0.086
Loa Loa (eye worm) hypothetical protein 0.0027 0.0029 0.0027
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0027 0.0029 0.0029
Trypanosoma cruzi phosphoglycerate mutase family member 5, putative 0.008 0.0141 0.0141
Onchocerca volvulus Protein UBASH3A homolog 0.008 0.0141 0.0122
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0013 0.0907
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0044 0.0044
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.011 0.011
Mycobacterium leprae Possible phosphoglycerate mutase 0.008 0.0141 0.7274
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0046 0.0755
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0046 0.0078
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0027 0.0029 0.0029
Schistosoma mansoni gliotactin 0.0022 0.002 0.002
Mycobacterium tuberculosis Conserved protein 0.0035 0.0046 0.0755
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.003 0.2135
Schistosoma mansoni hypothetical protein 0.0065 0.011 0.011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0027 0.0029 0.0027
Loa Loa (eye worm) hypothetical protein 0.0035 0.0046 0.0044
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0013 0.0907
Giardia lamblia PHD finger protein 15 0.0028 0.0032 0.0054
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0159 0.0309 0.0306
Brugia malayi hypothetical protein 0.0018 0.001 0.0046
Loa Loa (eye worm) hypothetical protein 0.0065 0.011 0.0108
Onchocerca volvulus Huntingtin homolog 0.0119 0.0223 0.0204
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0046 0.086
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0087 0.0156 0.2582
Brugia malayi jmjC domain containing protein 0.0093 0.0168 0.08
Loa Loa (eye worm) hypothetical protein 0.008 0.0141 0.0139
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0044 0.0044
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0053 0.0053
Brugia malayi Carboxylesterase family protein 0.0133 0.0253 0.121
Brugia malayi steroid hormone receptor 0.0027 0.0029 0.0139
Schistosoma mansoni 6-phosphofructokinase 0.4743 1 1
Onchocerca volvulus Huntingtin homolog 0.0119 0.0223 0.0204
Loa Loa (eye worm) hypothetical protein 0.0119 0.0223 0.0221
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0027 0.0029 0.0029
Brugia malayi Steroid receptor seven-up type 2 0.0027 0.0029 0.0139
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0087 0.0156 0.2582
Brugia malayi Thioredoxin reductase 0.0038 0.0053 0.0252
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0095 0.0093
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.1022 0.2132 0.2132
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0029 0.0029
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0027 0.0029 0.0029
Mycobacterium tuberculosis Conserved protein 0.0035 0.0046 0.0755
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0022 0.002 0.0322
Echinococcus multilocularis phosphoglycerate mutase 0.008 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0017
Toxoplasma gondii phosphoglycerate mutase family protein 0.008 0.0141 1
Toxoplasma gondii phosphoglycerate mutase family protein 0.008 0.0141 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0235 0.0469 0.224
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0046 0.0046
Brugia malayi Calcitonin receptor-like protein seb-1 0.0207 0.0409 0.1952
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0235 0.0469 0.0469
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0044 0.0044
Schistosoma mansoni alpha-glucosidase 0.0137 0.0262 0.0262
Onchocerca volvulus 0.0027 0.0029 0.001
Onchocerca volvulus Protein UBASH3A homolog 0.008 0.0141 0.0122
Toxoplasma gondii ABC1 family protein 0.0035 0.0046 0.3237
Mycobacterium ulcerans phosphoglycerate mutase 0.008 0.0141 0.024
Schistosoma mansoni retinoic acid receptor RXR 0.0027 0.0029 0.0029
Echinococcus multilocularis geminin 0.1022 0.2132 0.2132
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0022 0.002 0.0367
Brugia malayi amidase 0.0101 0.0186 0.0888
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0046 0.0046
Schistosoma mansoni phosphoglycerate mutase 0.008 0.0141 0.0141
Mycobacterium ulcerans phosphohistidine phosphatase SixA 0.008 0.0141 0.024
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0032 0.2244
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0014 0.0002 0.0002
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0013 0.0022
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0022 0.002 0.002
Mycobacterium leprae conserved hypothetical protein 0.008 0.0141 0.7274
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0013 0.0011
Toxoplasma gondii phosphoglycerate mutase PGMII 0.008 0.0141 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.0223 0.0221
Mycobacterium ulcerans hypothetical protein 0.0035 0.0046 0.0078
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0027 0.0029 0.0027
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.2799 0.589 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0021 0.039
Mycobacterium tuberculosis Conserved protein 0.008 0.0141 0.2331
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.4743 1 1
Brugia malayi jmjC domain containing protein 0.0036 0.0048 0.0228
Echinococcus granulosus cpg binding protein 0.0031 0.0038 0.0038
Mycobacterium tuberculosis Conserved protein 0.0035 0.0046 0.0755
Schistosoma mansoni hypothetical protein 0.008 0.0141 0.0141
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0032 0.2244
Trichomonas vaginalis phosphoglycerate mutase, putative 0.008 0.0141 0.2657
Onchocerca volvulus Epoxide hydrolase 1 homolog 0.2023 0.4249 0.4237
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0046 0.0046
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0013 0.0907
Schistosoma mansoni importin beta-1 0.0028 0.0032 0.0032
Mycobacterium tuberculosis Glucosyl-3-phosphoglycerate phosphatase GpgP 0.008 0.0141 0.2331
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0047 0.0223
Schistosoma mansoni hypothetical protein 0.0304 0.0614 0.0614
Loa Loa (eye worm) phosphoglycerate mutase 0.008 0.0141 0.0139
Echinococcus multilocularis phosphoglycerate mutase 0.008 0.0141 0.0141
Schistosoma mansoni hypothetical protein 0.008 0.0141 0.0141
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0047 0.0047
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.0309 0.0309
Mycobacterium ulcerans hypothetical protein 0.008 0.0141 0.024
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0046 0.0046
Trypanosoma cruzi Histidine phosphatase superfamily (branch 1), putative 0.008 0.0141 0.0141
Trypanosoma cruzi phosphoglycerate mutase family member 5, putative 0.008 0.0141 0.0141
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.003 0.003
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.003 0.2135
Loa Loa (eye worm) hypothetical protein 0.0101 0.0186 0.0184
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0047 0.0047
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0046 0.0755
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0168 0.0168
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0029 0.0029
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0044 0.0044
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.0029 0.0139
Plasmodium falciparum importin beta, putative 0.0028 0.0032 0.2274
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0046 0.0755
Trichomonas vaginalis esterase, putative 0.0035 0.0046 0.086
Loa Loa (eye worm) hypothetical protein 0.2719 0.5721 0.572
Brugia malayi hypothetical protein 0.0014 0.0002 0.001
Trypanosoma brucei glycerolphosphate mutase, putative 0.008 0.0141 0.0141
Brugia malayi Carboxylesterase family protein 0.0022 0.002 0.0093
Mycobacterium leprae POSSIBLE HYDROLASE MUTT1 0.008 0.0141 0.7274
Onchocerca volvulus 0.008 0.0141 0.0122
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0047 0.0058
Onchocerca volvulus Alhambra homolog 0.0028 0.0032 0.0012
Mycobacterium tuberculosis Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM) 0.008 0.0141 0.2331
Mycobacterium leprae PROBABLE PHOSPHOGLYCERATE MUTASE (PHOSPHOGLYCEROMUTASE) 0.008 0.0141 0.7274
Leishmania major phosphoglycerate mutase protein, putative 0.008 0.0141 0.0141
Trypanosoma brucei Histidine phosphatase superfamily (branch 1), putative 0.008 0.0141 0.0141
Echinococcus granulosus importin subunit beta 1 0.0028 0.0032 0.0032
Onchocerca volvulus 0.0092 0.0167 0.0147
Onchocerca volvulus Protein ultraspiracle homolog 0.0027 0.0029 0.001
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0168 0.0168
Echinococcus multilocularis phosphoglycerate mutase 0.008 0.0141 0.0141
Echinococcus granulosus serine:threonine protein phosphatase PGAM5 0.008 0.0141 0.0141
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0022 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.0028
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0087 0.0156 0.2582

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 10 ug ml-1 Antibacterial activity against Escherichia coli after 3 mins. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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