TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 372.794 | Formula: C17H19ClF2N2O3
H donors: 2 H acceptors: 3 LogP: 1.43 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CC(NCc1c(F)cc2c(c1F)n(cc(c2=O)C(=O)O)C1CC1)C.Cl
InChi: 1S/C17H18F2N2O3.ClH/c1-8(2)20-6-11-13(18)5-10-15(14(11)19)21(9-3-4-9)7-12(16(10)22)17(23)24;/h5,7-9,20H,3-4,6H2,1-2H3,(H,23,24);1H
InChiKey: UXSDPVJDKVUAMU-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0079	0.1763	0.1763
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0079	0.1763	0.1763
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0122	0.2794	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0079	0.1763	0.1763
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0122	0.2794	0.2794
Leishmania major	hypothetical protein, conserved	0.0038	0.0756	0.2704
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0079	0.1763	0.1763
Brugia malayi	beta-lactamase family protein	0.0038	0.0756	0.2546
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1763	0.3418
Brugia malayi	G protein-coupled receptor	0.0079	0.1763	0.5941
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0079	0.1763	0.1763
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1763	0.3418
Toxoplasma gondii	aldehyde dehydrogenase	0.0122	0.2794	1
Echinococcus granulosus	g-protein coupled receptor	0.0079	0.1763	0.1763
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0038	0.0756	0.0756
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0079	0.1763	0.1763
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0079	0.1763	0.3418
Onchocerca volvulus		0.0079	0.1763	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0265	0.0465
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0008	0.0031	0.0031
Echinococcus granulosus	g protein coupled receptor	0.0079	0.1763	0.1763
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0756	1
Loa Loa (eye worm)	hypothetical protein	0.0092	0.2083	0.4039
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0079	0.1763	0.1763
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0617	0.1196
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0025	0.0443	0.1586
Brugia malayi	follicle stimulating hormone receptor	0.0079	0.1763	0.5941
Schistosoma mansoni	aldehyde dehydrogenase	0.0122	0.2794	0.2794
Loa Loa (eye worm)	neuropeptide F receptor	0.0079	0.1763	0.3418
Schistosoma mansoni	hypothetical protein	0.0032	0.0617	0.0617
Brugia malayi	hypothetical protein	0.0079	0.1763	0.5941
Schistosoma mansoni	amine GPCR	0.0079	0.1763	0.1763
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1763	0.3418
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0079	0.1763	0.1763
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0079	0.1763	0.5941
Schistosoma mansoni	hypothetical protein	0.0069	0.1521	0.1521
Echinococcus granulosus	rhodopsin orphan GPCR	0.0079	0.1763	0.1763
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1763	0.3418
Loa Loa (eye worm)	hypothetical protein	0.0019	0.029	0.0562
Schistosoma mansoni	hypothetical protein	0.0079	0.1763	0.1763
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0008	0.0031	0.0031
Brugia malayi	hypothetical protein	0.0079	0.1763	0.5941
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0079	0.1763	0.1763
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0079	0.1763	0.1763
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0015	0.0029
Leishmania major	acetyl-CoA synthetase, putative	0.0007	0.0015	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1763	0.3418
Schistosoma mansoni	tar DNA-binding protein	0.0129	0.2967	0.2967
Mycobacterium ulcerans	hypothetical protein	0.0025	0.0443	0.1586
Schistosoma mansoni	hypothetical protein	0.0032	0.0617	0.0617
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0058	0.0058
Brugia malayi	MH1 domain containing protein	0.0008	0.0031	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1763	0.3418
Brugia malayi	Serotonin receptor	0.0079	0.1763	0.5941
Echinococcus granulosus	Smad4	0.0008	0.0031	0.0031
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0079	0.1763	0.1763
Echinococcus granulosus	neuropeptide receptor A26	0.0079	0.1763	0.1763
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0008	0.0031	0.0031
Onchocerca volvulus		0.0007	0.0015	0.0086
Echinococcus granulosus	beta LACTamase domain containing family member	0.0038	0.0756	0.0756
Brugia malayi	putative neuropeptide receptor	0.0079	0.1763	0.5941
Echinococcus multilocularis	tar DNA binding protein	0.0129	0.2967	0.2967
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0007	0.0015	0.0027
Schistosoma mansoni	biogenic amine receptor	0.0079	0.1763	0.1763
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1763	0.3418
Echinococcus granulosus	mothers against decapentaplegic 5	0.0008	0.0031	0.0031
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0265	0.0465
Schistosoma mansoni	amine GPCR	0.0079	0.1763	0.1763
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0079	0.1763	0.1763
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0015	0.0015
Onchocerca volvulus		0.0079	0.1763	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0058	0.0058
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0007	0.0015	0.0051
Mycobacterium ulcerans	acyl-CoA synthetase	0.0007	0.0015	0.0054
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0092	0.2083	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0079	0.1763	0.1763
Onchocerca volvulus		0.0079	0.1763	1
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0015	0.0029
Trichomonas vaginalis	antibiotic synthetase, putative	0.0007	0.0015	0.0201
Mycobacterium ulcerans	esterase/lipase LipP	0.0038	0.0756	0.2704
Brugia malayi	Dopamine receptor protein 2	0.0079	0.1763	0.5941
Mycobacterium ulcerans	hypothetical protein	0.0038	0.0756	0.2704
Loa Loa (eye worm)	hypothetical protein	0.0101	0.2301	0.446
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0756	0.1325
Brugia malayi	neuropeptide F receptor	0.0079	0.1763	0.5941
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0015	0.0027
Echinococcus multilocularis	cpg binding protein	0.0031	0.0592	0.0592
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0443	0.1494
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0092	0.2083	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0219	0.5158	0.5158
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0015	0.0027
Mycobacterium ulcerans	acyl-CoA synthetase	0.0007	0.0015	0.0054
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0007	0.0015	0.0054
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0092	0.2083	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0617	0.2078
Mycobacterium ulcerans	acetyl-CoA synthetase	0.0007	0.0015	0.0054
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0007	0.0015	0.0027
Loa Loa (eye worm)	RNA binding protein	0.0129	0.2967	0.5753
Brugia malayi	beta-lactamase family protein	0.0038	0.0756	0.2546
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.0756	0.0756
Brugia malayi	ORL1-like opioid receptor	0.0079	0.1763	0.5941
Echinococcus multilocularis	G protein coupled receptor 139	0.0079	0.1763	0.1763
Loa Loa (eye worm)	TYRA-2 protein	0.0079	0.1763	0.3418
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0079	0.1763	0.1763
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0617	0.0617
Mycobacterium ulcerans	acyl-CoA synthetase	0.0007	0.0015	0.0054
Mycobacterium ulcerans	acyl-CoA synthetase	0.0007	0.0015	0.0054
Onchocerca volvulus		0.0079	0.1763	1
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0007	0.0015	0.0027
Echinococcus multilocularis	g protein coupled receptor	0.0079	0.1763	0.1763
Schistosoma mansoni	opsin-like receptor	0.0079	0.1763	0.1763
Schistosoma mansoni	hypothetical protein	0.0032	0.0617	0.0617
Onchocerca volvulus		0.0079	0.1763	1
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0007	0.0015	0.0015
Onchocerca volvulus		0.0079	0.1763	1
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0031	0.0031
Schistosoma mansoni	smad	0.0008	0.0031	0.0031
Loa Loa (eye worm)	beta-lactamase	0.0038	0.0756	0.1465
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0079	0.1763	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0079	0.1763	0.1763
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0102	0.232	0.232
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0122	0.2794	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0079	0.1763	0.1763
Onchocerca volvulus		0.0007	0.0015	0.0086
Onchocerca volvulus		0.0038	0.0756	0.4286
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0025	0.0443	0.1586
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0015	0.0051
Schistosoma mansoni	hypothetical protein	0.0079	0.1763	0.1763
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0443	0.1586
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0007	0.0015	0.0051
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0756	1
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0007	0.0015	0.0027
Schistosoma mansoni	hypothetical protein	0.0351	0.8369	0.8369
Schistosoma mansoni	aldehyde dehydrogenase	0.0122	0.2794	0.2794
Toxoplasma gondii	hypothetical protein	0.0032	0.0611	0.2187
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0101	0.2301	0.7753
Brugia malayi	MH2 domain containing protein	0.0008	0.0031	0.0106
Brugia malayi	G-protein coupled receptor	0.0079	0.1763	0.5941
Trichomonas vaginalis	antibiotic synthetase, putative	0.0007	0.0015	0.0201
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0007	0.0015	0.0201
Onchocerca volvulus		0.0079	0.1763	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1763	0.3418
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0102	0.232	0.4498
Echinococcus multilocularis	geminin	0.0351	0.8369	0.8369
Loa Loa (eye worm)	neuropeptide F receptor	0.0079	0.1763	0.3418
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	0.0032	0.0611	0.2933
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0079	0.1763	0.1763
Brugia malayi	hypothetical protein	0.0079	0.1763	0.5941
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0092	0.2083	0.7455
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0079	0.1763	0.3418
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0015	0.0015
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0079	0.1763	0.1763
Brugia malayi	hypothetical protein	0.0079	0.1763	0.5941
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0007	0.0015	0.0201
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0092	0.2083	1
Mycobacterium leprae	Probable lipase LipE	0.0038	0.0756	0.3627
Echinococcus granulosus	neuropeptides capa receptor	0.0079	0.1763	0.1763
Loa Loa (eye worm)	hypothetical protein	0.0019	0.029	0.0562
Loa Loa (eye worm)	TAR-binding protein	0.0129	0.2967	0.5753
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1763	0.3418
Mycobacterium ulcerans	lipase LipD	0.0038	0.0756	0.2704
Echinococcus granulosus	neuropeptide receptor	0.0079	0.1763	0.1763
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0079	0.1763	0.1763
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0092	0.2083	1
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtF	0.0007	0.0015	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1763	0.3418
Mycobacterium ulcerans	beta-lactamase	0.0038	0.0756	0.2704
Mycobacterium tuberculosis	Probable lipase LipD	0.0038	0.0756	0.1325
Brugia malayi	Serotonin receptor	0.0079	0.1763	0.5941
Loa Loa (eye worm)	MH2 domain-containing protein	0.0008	0.0031	0.0061
Echinococcus multilocularis	neuropeptide receptor A26	0.0079	0.1763	0.1763
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1763	0.3418
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1763	0.3418
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0122	0.2794	1
Onchocerca volvulus		0.0079	0.1763	1
Echinococcus granulosus	neuropeptide s receptor	0.0079	0.1763	0.1763
Brugia malayi	Dopamine receptor	0.0079	0.1763	0.5941
Mycobacterium ulcerans	bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase	0.0007	0.0015	0.0054
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0079	0.1763	0.1763
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0102	0.232	0.232
Echinococcus granulosus	neuropeptide receptor	0.0079	0.1763	0.1763
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0443	0.1586
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1763	0.3418
Schistosoma mansoni	myosin xvIII	0.0079	0.1763	0.1763
Schistosoma mansoni	neuropeptide receptor	0.0079	0.1763	0.1763
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0079	0.1763	0.1763
Schistosoma mansoni	neuropeptide f receptor 76f	0.0079	0.1763	0.1763
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0079	0.1763	0.1763
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0038	0.0756	0.2546
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0617	0.1196
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0079	0.1763	0.5941
Mycobacterium tuberculosis	Probable esterase LipL	0.0038	0.0756	0.1325
Schistosoma mansoni	growth hormone secretagogue receptor	0.0079	0.1763	0.1763
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0079	0.1763	0.1763
Loa Loa (eye worm)	hypothetical protein	0.0019	0.029	0.0562
Echinococcus multilocularis	g-protein coupled receptor	0.0079	0.1763	0.1763
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.0617	0.0617
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0038	0.0756	0.1465
Onchocerca volvulus		0.0007	0.0015	0.0086
Schistosoma mansoni	tar DNA-binding protein	0.0129	0.2967	0.2967
Brugia malayi	sulfakinin receptor protein	0.0079	0.1763	0.5941
Mycobacterium leprae	conserved hypothetical protein	0.0038	0.0756	0.3627
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0079	0.1763	0.1763
Brugia malayi	neuropeptide F receptor	0.0079	0.1763	0.5941
Echinococcus multilocularis	neuropeptide Y receptor	0.0079	0.1763	0.1763
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0079	0.1763	0.1763
Echinococcus granulosus	neuropeptides capa receptor	0.0079	0.1763	0.1763
Schistosoma mansoni	neuropeptide receptor	0.0079	0.1763	0.1763
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0008	0.0031	0.0031
Mycobacterium ulcerans	phenyloxazoline synthase MbtB	0.0007	0.0015	0.0054
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0079	0.1763	0.1763
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0443	0.1494
Echinococcus multilocularis	serotonin receptor	0.0219	0.5158	0.5158
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0061	0.1309	0.1309
Loa Loa (eye worm)	MH1 domain-containing protein	0.0008	0.0031	0.0061
Brugia malayi	MH2 domain containing protein	0.0117	0.2685	0.9049
Schistosoma mansoni	opsin-like receptor	0.0079	0.1763	0.1763
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.0756	1
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0031	0.0031
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0092	0.2083	0.7455
Echinococcus multilocularis	allatostatin A receptor	0.0079	0.1763	0.1763
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtE	0.0007	0.0015	0.0054
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0079	0.1763	0.1763
Echinococcus multilocularis	g protein coupled receptor	0.0079	0.1763	0.1763
Loa Loa (eye worm)	G-protein coupled receptor	0.0079	0.1763	0.3418
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0443	1
Brugia malayi	RE15519p	0.0079	0.1763	0.5941
Schistosoma mansoni	adenoreceptor	0.0079	0.1763	0.1763
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0032	0.0611	0.2933
Echinococcus granulosus	somatostatin receptor	0.0079	0.1763	0.1763
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.1351	0.1351
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0079	0.1763	0.1763
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0443	0.0859
Schistosoma mansoni	biogenic amine receptor	0.0079	0.1763	0.1763
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0756	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0443	0.1586
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0015	0.0051
Mycobacterium ulcerans	long-chain-acyl-CoA synthetase	0.0007	0.0015	0.0054
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0015	0.0015
Onchocerca volvulus		0.0025	0.0443	0.2514
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0092	0.2083	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0756	0.1465
Brugia malayi	hypothetical protein	0.0079	0.1763	0.5941
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0102	0.232	0.7818
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1763	0.3418
Echinococcus granulosus	rhodopsin orphan GPCR	0.0079	0.1763	0.1763
Schistosoma mansoni	biogenic amine receptor	0.0079	0.1763	0.1763
Brugia malayi	hypothetical protein	0.0079	0.1763	0.5941
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0079	0.1763	0.1763
Schistosoma mansoni	neuropeptide F-like receptor	0.0079	0.1763	0.1763
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0102	0.232	0.232
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0756	0.1465
Echinococcus multilocularis	orexin receptor type 2	0.0079	0.1763	0.1763
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0079	0.1763	0.1763
Trypanosoma brucei	hypothetical protein, conserved	0.0038	0.0756	1
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0007	0.0015	0.0201
Echinococcus multilocularis	serotonin receptor	0.0219	0.5158	0.5158
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1763	0.3418
Schistosoma mansoni	Smad4	0.0008	0.0031	0.0031
Schistosoma mansoni	neuropeptide receptor	0.0079	0.1763	0.1763
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0007	0.0015	0.0201
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0.0443	0.2128
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0079	0.1763	0.1763
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1763	0.3418
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0079	0.1763	0.1763
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0443	0.1586
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0079	0.1763	0.1763
Echinococcus granulosus	rhodopsin orphan GPCR	0.0079	0.1763	0.1763
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0092	0.2083	0.2083
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1763	0.3418
Brugia malayi	larval opioid receptor	0.0079	0.1763	0.5941
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1763	0.3418
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0617	0.0617
Mycobacterium ulcerans	acyl-CoA synthetase	0.0007	0.0015	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1763	0.3418
Echinococcus granulosus	7tm_1 domain containing protein	0.0079	0.1763	0.1763
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1763	0.3418
Schistosoma mansoni	cpg binding protein	0.0031	0.0592	0.0592
Onchocerca volvulus		0.0079	0.1763	1
Schistosoma mansoni	hypothetical protein	0.0351	0.8369	0.8369
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0015	0.0027
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0056	0.1189	0.4255
Onchocerca volvulus		0.0079	0.1763	1
Mycobacterium leprae	POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0007	0.0015	0.0073
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0007	0.0015	0.0027
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0007	0.0015	0.0027
Onchocerca volvulus		0.0079	0.1763	1
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0007	0.0015	0.0029
Echinococcus granulosus	tar DNA binding protein	0.0129	0.2967	0.2967
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0219	0.5158	0.5158
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0031	0.0031
Loa Loa (eye worm)	melatonin receptor type 1A	0.0079	0.1763	0.3418
Onchocerca volvulus		0.0079	0.1763	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1763	0.3418
Schistosoma mansoni	tar DNA-binding protein	0.0129	0.2967	0.2967
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0101	0.2301	0.446
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1763	0.3418
Echinococcus granulosus	geminin	0.0351	0.8369	0.8369
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1763	0.3418
Echinococcus granulosus	rhodopsin orphan GPCR	0.0079	0.1763	0.1763
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0025	0.0443	0.0777
Onchocerca volvulus		0.0079	0.1763	1
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0058	0.0113
Mycobacterium ulcerans	O-succinylbenzoic acid--CoA ligase	0.0007	0.0015	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0019	0.029	0.0562
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0122	0.2794	0.4899
Echinococcus granulosus	tm gpcr rhodopsin	0.0079	0.1763	0.1763
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0079	0.1763	0.1763
Echinococcus granulosus	sex peptide receptor	0.0079	0.1763	0.1763
Schistosoma mansoni	neuropeptide F-like receptor	0.0079	0.1763	0.1763
Mycobacterium tuberculosis	Probable lipase LipE	0.0038	0.0756	0.1325
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0079	0.1763	0.1763
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1763	0.3418
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0079	0.1763	0.1763
Brugia malayi	hypothetical protein	0.0079	0.1763	0.5941
Schistosoma mansoni	hypothetical protein	0.0079	0.1763	0.1763
Echinococcus multilocularis	sex peptide receptor	0.0079	0.1763	0.1763
Schistosoma mansoni	cpg binding protein	0.0029	0.0551	0.0551
Echinococcus multilocularis	dnaJ subfamily B	0.0418	1	1
Echinococcus multilocularis	fmrfamide receptor	0.0079	0.1763	0.1763
Echinococcus granulosus	tm gpcr rhodopsin	0.0079	0.1763	0.1763
Brugia malayi	G-protein coupled receptor	0.0079	0.1763	0.5941
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0061	0.1309	0.2296
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0079	0.1763	0.5941
Brugia malayi	latrophilin 2 splice variant baaae	0.0069	0.1521	0.5126
Brugia malayi	putative neuropeptide receptor NPR1	0.0079	0.1763	0.5941
Echinococcus granulosus	7TM GPCR rhodopsin	0.0079	0.1763	0.1763
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.0617	0.0617
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0122	0.2794	0.2794
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0079	0.1763	0.1763
Onchocerca volvulus		0.0007	0.0015	0.0086
Mycobacterium ulcerans	acyl-CoA synthetase	0.0007	0.0015	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1763	0.3418
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1763	0.3418
Onchocerca volvulus		0.0079	0.1763	1
Brugia malayi	MH2 domain containing protein	0.0008	0.0031	0.0106
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0122	0.2794	1
Echinococcus granulosus	hypothetical protein	0.0079	0.1763	0.1763
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0265	0.0465
Echinococcus multilocularis	neuropeptides capa receptor	0.0079	0.1763	0.1763
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0079	0.1763	0.1763
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0032	0.0611	0.2881
Trichomonas vaginalis	esterase, putative	0.0038	0.0756	1
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0038	0.0756	0.1325
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0129	0.2967	0.5753
Echinococcus multilocularis	fmrfamide receptor	0.0079	0.1763	0.1763
Brugia malayi	MH1 domain containing protein	0.0008	0.0031	0.0106
Echinococcus multilocularis	dro:myosuppressin receptor	0.0079	0.1763	0.1763
Echinococcus granulosus	orexin receptor type 2	0.0079	0.1763	0.1763
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0102	0.232	0.232
Brugia malayi	Dopamine receptor protein 1	0.0079	0.1763	0.5941
Onchocerca volvulus		0.0038	0.0756	0.4286
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0079	0.1763	0.1763
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0079	0.1763	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0079	0.1763	0.1763
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0032	0.0611	0.2881
Echinococcus granulosus	fmrfamide receptor	0.0079	0.1763	0.1763
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1763	0.3418
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0079	0.1763	0.1763
Loa Loa (eye worm)	hypothetical protein	0.0019	0.029	0.0562
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0242	0.5704	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0079	0.1763	0.1763
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0079	0.1763	0.1763
Onchocerca volvulus		0.0079	0.1763	1
Echinococcus multilocularis	neuropeptide s receptor	0.0079	0.1763	0.1763
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0101	0.2301	0.7753
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.0756	1
Toxoplasma gondii	propionate-CoA ligase	0.0007	0.0015	0.0054
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0079	0.1763	0.1763
Brugia malayi	RNA binding protein	0.0129	0.2967	1
Echinococcus multilocularis	Smad4	0.0008	0.0031	0.0031
Echinococcus granulosus	G protein coupled receptor 139	0.0079	0.1763	0.1763
Echinococcus multilocularis	neuropeptides capa receptor	0.0079	0.1763	0.1763
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0265	0.0465
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0079	0.1763	0.1763
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1763	0.3418
Entamoeba histolytica	acyl-coA synthetase, putative	0.0025	0.0443	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0079	0.1763	0.1763
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0617	0.0617
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0079	0.1763	0.1763
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0007	0.0015	0.0054
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0092	0.2083	0.2083
Echinococcus granulosus	peptidase Clp S14 family	0.0061	0.1309	0.1309
Echinococcus multilocularis	g protein coupled receptor	0.0079	0.1763	0.1763
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0443	0.1494
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0007	0.0015	0.0029
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0079	0.1763	0.1763
Mycobacterium leprae	Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase)	0.0007	0.0015	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1763	0.3418
Echinococcus granulosus	rhodopsin orphan GPCR	0.0079	0.1763	0.1763
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0079	0.1763	0.1763
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1763	0.3418
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1763	0.3418
Brugia malayi	GnHR receptor homolog	0.0079	0.1763	0.5941
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0092	0.2083	0.7455
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0102	0.232	0.232
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0756	0.1465
Brugia malayi	Melatonin receptor type 1A	0.0079	0.1763	0.5941
Echinococcus granulosus	allatostatin A receptor	0.0079	0.1763	0.1763
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0443	0.1586
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0.0443	0.2128
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1763	0.3418
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0079	0.1763	0.1763
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0079	0.1763	0.1763
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0079	0.1763	0.3418
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1763	0.3418
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0061	0.1309	0.6286
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0756	0.1465
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1521	0.2949
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0551	0.1068
Schistosoma mansoni	amine GPCR	0.0079	0.1763	0.1763
Plasmodium vivax	acyl-CoA synthetase, putative	0.0019	0.029	0.1329
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0015	0.0051
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0079	0.1763	0.1763
Loa Loa (eye worm)	hypothetical protein	0.0219	0.5158	1
Schistosoma mansoni	tar DNA-binding protein	0.0129	0.2967	0.2967
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0007	0.0015	0.0054
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0019	0.029	0.0509
Brugia malayi	beta-lactamase	0.0038	0.0756	0.2546
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0079	0.1763	0.1763
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0055	0.0186
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0102	0.232	0.232
Echinococcus granulosus	cpg binding protein	0.0031	0.0592	0.0592
Echinococcus multilocularis	neuropeptide receptor	0.0079	0.1763	0.1763
Brugia malayi	RNA recognition motif domain containing protein	0.0129	0.2967	1
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0025	0.0443	0.1586
Echinococcus granulosus	neuropeptide FF receptor 2	0.0079	0.1763	0.1763
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0015	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1763	0.3418
Brugia malayi	hypothetical protein	0.0079	0.1763	0.5941
Onchocerca volvulus		0.0079	0.1763	1
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0061	0.1309	0.2296
Brugia malayi	hypothetical protein	0.0079	0.1763	0.5941
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0079	0.1763	0.1763
Mycobacterium tuberculosis	Probable hydrolase	0.0038	0.0756	0.1325
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1763	0.3418
Onchocerca volvulus		0.0029	0.0551	0.3124
Schistosoma mansoni	hypothetical protein	0.0079	0.1763	0.1763
Brugia malayi	hypothetical protein	0.0079	0.1763	0.5941
Brugia malayi	AKH receptor	0.0079	0.1763	0.5941
Leishmania major	acetyl-CoA synthetase, putative	0.0007	0.0015	0.0054
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0756	0.1325
Loa Loa (eye worm)	transcription factor SMAD2	0.0117	0.2685	0.5206
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1763	0.3418
Brugia malayi	G protein-coupled receptor F59B2.13	0.0079	0.1763	0.5941
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0079	0.1763	0.1763
Mycobacterium ulcerans	peptide synthetase Nrp (peptide synthase)	0.0007	0.0015	0.0054
Mycobacterium leprae	POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE)	0.0007	0.0015	0.0073
Echinococcus granulosus	rhodopsin orphan GPCR	0.0079	0.1763	0.1763
Echinococcus granulosus	GPCR family 2	0.0032	0.0617	0.0617
Onchocerca volvulus		0.0038	0.0756	0.4286
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0079	0.1763	0.1763
Loa Loa (eye worm)	MH2 domain-containing protein	0.0117	0.2685	0.5206
Plasmodium vivax	hypothetical protein, conserved	0.0038	0.0756	0.358
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0015	0.0027
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0756	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1763	0.3418
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1763	0.3418
Schistosoma mansoni	acetyl-CoA synthetase	0.0007	0.0015	0.0015
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0038	0.0756	0.2704
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0007	0.0015	0.0201
Loa Loa (eye worm)	Smad1	0.0008	0.0031	0.0061
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0038	0.0756	0.1325
Schistosoma mansoni	amine GPCR	0.0079	0.1763	0.1763
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	0.0007	0.0015	0.0343
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0079	0.1763	0.1763
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0079	0.1763	0.3418
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1763	0.3418
Echinococcus multilocularis	smad	0.0008	0.0031	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0756	0.1465
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0079	0.1763	0.5941
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0092	0.2083	1
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0007	0.0015	0.0015
Echinococcus multilocularis	neuropeptide receptor	0.0079	0.1763	0.1763
Loa Loa (eye worm)	oxidoreductase	0.0007	0.0015	0.0029
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0617	0.2078
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0038	0.0756	0.1325
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0551	0.1856
Mycobacterium ulcerans	acyl-CoA synthetase	0.0007	0.0015	0.0054
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0079	0.1763	0.5941
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0443	1
Echinococcus granulosus	g protein coupled receptor	0.0079	0.1763	0.1763
Leishmania major	long-chain-fatty-acid-CoA ligase, putative	0.0007	0.0015	0.0054
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0079	0.1763	0.1763
Schistosoma mansoni	tar DNA-binding protein	0.0129	0.2967	0.2967
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0079	0.1763	0.3418
Echinococcus granulosus	g protein coupled receptor	0.0079	0.1763	0.1763
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0025	0.0443	0.1586
Schistosoma mansoni	histamine h1 receptor	0.0079	0.1763	0.1763
Mycobacterium ulcerans	acyl-CoA synthetase	0.0007	0.0015	0.0054
Schistosoma mansoni	cpg binding protein	0.0031	0.0592	0.0592
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0015	0.0015
Brugia malayi	Smad1	0.0008	0.0031	0.0106
Toxoplasma gondii	ABC1 family protein	0.0038	0.0756	0.2704
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0443	0.0859
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0443	0.0859
Schistosoma mansoni	hypothetical protein	0.0418	1	1
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0007	0.0015	0.0027
Echinococcus multilocularis	somatostatin receptor	0.0079	0.1763	0.1763
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1763	0.3418
Schistosoma mansoni	peptidase Clp (S14 family)	0.0092	0.2083	0.2083
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0756	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0102	0.232	0.232
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.0756	0.0756
Brugia malayi	TAR-binding protein	0.0129	0.2967	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1763	0.3418
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0756	0.1325
Echinococcus granulosus	neuropeptide Y receptor	0.0079	0.1763	0.1763
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1763	0.3418
Echinococcus granulosus	tm gpcr rhodopsin	0.0079	0.1763	0.1763
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0079	0.1763	0.1763
Echinococcus granulosus	neuropeptide Y receptor	0.0079	0.1763	0.1763
Echinococcus granulosus	serotonin receptor	0.0079	0.1763	0.1763
Schistosoma mansoni	neuropeptide receptor	0.0079	0.1763	0.1763
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0025	0.0443	0.0777
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0019	0.029	0.1038
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1763	0.3418
Schistosoma mansoni	amine GPCR	0.0079	0.1763	0.1763
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0007	0.0015	0.0201
Echinococcus granulosus	dro:myosuppressin receptor	0.0079	0.1763	0.1763
Giardia lamblia	Alcohol dehydrogenase	0.0007	0	0.5
Onchocerca volvulus		0.0079	0.1763	1
Brugia malayi	Probable ClpP-like protease	0.0092	0.2083	0.702
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0756	0.1465
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0092	0.2083	0.7455
Schistosoma mansoni	hypothetical protein	0.0032	0.0617	0.0617
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0443	0.1586
Loa Loa (eye worm)	hypothetical protein	0.0219	0.5158	1
Echinococcus granulosus	smad	0.0008	0.0031	0.0031
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0079	0.1763	0.1763
Schistosoma mansoni	opsin-like receptor	0.0079	0.1763	0.1763
Plasmodium falciparum	acyl-CoA synthetase	0.0019	0.029	0.1329
Loa Loa (eye worm)	G-protein coupled receptor	0.0079	0.1763	0.3418
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0079	0.1763	0.5941

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL545299

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1035436