Detailed information for compound 1035534

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 507.926 | Formula: C18H30ClN7O8
  • H donors: 9 H acceptors: 8 LogP: -3.81 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 3
  • SMILES: NC(=N)NCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@@H]([C@H]2O)O)NC(=O)[C@@H](NC(=O)CNC1=O)CC(=O)O.Cl
  • InChi: 1S/C18H29N7O8.ClH/c19-18(20)21-3-1-2-8-16(32)22-6-11(26)23-10(5-12(27)28)17(33)25-9-4-7(15(31)24-8)13(29)14(9)30;/h7-10,13-14,29-30H,1-6H2,(H,22,32)(H,23,26)(H,24,31)(H,25,33)(H,27,28)(H4,19,20,21);1H/t7-,8-,9+,10-,13-,14-;/m0./s1
  • InChiKey: CXPGXICNBPAFLM-NTZOAZHJSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) Starlite/ChEMBL References
Homo sapiens integrin, beta 5 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Integrin beta-PS precursor, putative Get druggable targets OG5_127959 All targets in OG5_127959
Schistosoma japonicum ko:K06464 integrin beta 2, putative Get druggable targets OG5_127959 All targets in OG5_127959
Schistosoma mansoni integrin beta subunit Get druggable targets OG5_127959 All targets in OG5_127959
Schistosoma japonicum Integrin beta-3 precursor, putative Get druggable targets OG5_127959 All targets in OG5_127959
Loa Loa (eye worm) integrin beta-2 Get druggable targets OG5_127959 All targets in OG5_127959
Echinococcus multilocularis integrin beta 2 Get druggable targets OG5_127959 All targets in OG5_127959
Brugia malayi Integrin beta pat-3 precursor Get druggable targets OG5_127959 All targets in OG5_127959
Echinococcus granulosus integrin beta 2 Get druggable targets OG5_127959 All targets in OG5_127959
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus potassium large conductance calcium activated 0.0046 0.006 0.0053
Trichomonas vaginalis CAMK family protein kinase 0.0208 0.0444 0.2581
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0037
Entamoeba histolytica acyl-CoA synthetase, putative 0.0149 0.0304 0.2145
Onchocerca volvulus 0.0193 0.0408 0.2381
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0258 0.0564 0.0608
Schistosoma mansoni alpha-glucosidase 0.0139 0.028 0.0302
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0044 0.0055 0.0511
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0151 0.1702
Trichomonas vaginalis chromobox protein, putative 0.0098 0.0183 0.1012
Trichomonas vaginalis ran, putative 0.0044 0.0055 0.0244
Loa Loa (eye worm) TYRA-2 protein 0.0025 0.001 0.0037
Loa Loa (eye worm) integrin beta-2 0.0817 0.1891 0.7118
Loa Loa (eye worm) hypothetical protein 0.0071 0.0121 0.0451
Loa Loa (eye worm) hypothetical protein 0.0044 0.0055 0.0204
Echinococcus multilocularis BC026374 protein (S09 family) 0.0193 0.0408 0.0398
Trypanosoma cruzi squalene synthase, putative 0.0267 0.0585 0.7051
Echinococcus granulosus glycine receptor subunit alpha 1 0.0071 0.0119 0.0117
Schistosoma mansoni neuropeptide F-like receptor 0.0025 0.001 0.0011
Brugia malayi CXXC zinc finger family protein 0.012 0.0236 0.0853
Echinococcus granulosus chromobox protein 1 0.0162 0.0335 0.035
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0036 0.028
Echinococcus granulosus neuroligin 0.0193 0.0408 0.0429
Entamoeba histolytica hypothetical protein 0.0177 0.0372 0.2641
Mycobacterium ulcerans recombinase A 0.0113 0.0218 0.0284
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0266 0.0582 0.0656
Schistosoma mansoni calcium-activated potassium channel 0.0046 0.006 0.0064
Trypanosoma cruzi polo-like protein kinase, putative 0.0208 0.0444 0.5309
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0025 0.001 0.0011
Onchocerca volvulus 0.0033 0.0028 0.0108
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0121 0.0101
Loa Loa (eye worm) hypothetical protein 0.0111 0.0215 0.0806
Loa Loa (eye worm) hypothetical protein 0.0034 0.0032 0.012
Loa Loa (eye worm) hypothetical protein 0.0111 0.0215 0.0809
Loa Loa (eye worm) beta-lactamase 0.0071 0.0121 0.0451
Loa Loa (eye worm) glutaminase 2 0.0285 0.0628 0.2363
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0036 0.0037 0.0033
Schistosoma mansoni terminal deoxycytidyl transferase 0.0084 0.0151 0.0163
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0055 0.0509
Echinococcus multilocularis microtubule associated protein 2 0.3931 0.9278 0.9278
Schistosoma mansoni alpha-glucosidase 0.0139 0.028 0.0302
Brugia malayi beta-lactamase 0.0071 0.0121 0.0416
Loa Loa (eye worm) hypothetical protein 0.0038 0.0041 0.0153
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0036 0.0133
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0039 0.0044 0.018
Trichomonas vaginalis glucosylceramidase, putative 0.0301 0.0664 0.3902
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0036 0.0028
Echinococcus multilocularis chromobox protein 1 0.0162 0.0335 0.0325
Trichomonas vaginalis glucosylceramidase, putative 0.0301 0.0664 0.3902
Mycobacterium ulcerans acetyl-CoA synthetase 0.0044 0.0055 0.0058
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0044 0.0055 0.0511
Leishmania major GTP-binding protein, putative 0.0044 0.0055 0.0509
Loa Loa (eye worm) hypothetical protein 0.0071 0.0119 0.0445
Loa Loa (eye worm) hypothetical protein 0.0033 0.0028 0.0104
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0025 0.001 0.0011
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0057 0.0086 0.0082
Onchocerca volvulus 0.0093 0.0172 0.097
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0121 0.0149
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.003 0.0022 0.0023
Schistosoma mansoni survival motor neuron protein 0.005 0.0071 0.0076
Echinococcus granulosus neuropeptide s receptor 0.1092 0.2542 0.2732
Trypanosoma brucei unspecified product 0.0084 0.0151 0.1702
Brugia malayi Importin beta-1 subunit 0.0059 0.0092 0.0307
Schistosoma mansoni biogenic amine (5HT) receptor 0.0025 0.001 0.0011
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0044 0.0055 0.0021
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0044 0.0055 0.0167
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0037
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0084 0.0151 0.0567
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0149 0.0304 0.0403
Loa Loa (eye worm) glutaminase 0.0285 0.0628 0.2363
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0193 0.0408 0.0429
Echinococcus multilocularis calcium activated potassium channel 0.0046 0.0061 0.0051
Brugia malayi Thioredoxin reductase 0.0105 0.02 0.0716
Brugia malayi Bromodomain containing protein 0.0083 0.0148 0.0518
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0037
Schistosoma mansoni hypothetical protein 0.0021 0.0001 0.0001
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0294 0.0648 0.0735
Echinococcus multilocularis Niemann Pick C1 protein 0.0198 0.0421 0.0411
Brugia malayi M-phase phosphoprotein, mpp8 0.0026 0.0014 0.0013
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0071 0.0119 0.0409
Schistosoma mansoni acetylcholine receptor subunit beta 0.0033 0.0028 0.0031
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0036 0.0037 0.0296
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0036 0.0133
Brugia malayi Calcitonin receptor-like protein seb-1 0.0418 0.0943 0.3523
Echinococcus multilocularis fetal alzheimer antigen, falz 0.003 0.0022 0.0011
Trypanosoma brucei glucosidase, putative 0.0036 0.0036 0.028
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0011 0.0039
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0239 0.0519 0.058
Loa Loa (eye worm) ACC-1 protein 0.0071 0.0119 0.0445
Plasmodium falciparum thioredoxin reductase 0.0105 0.02 0.4147
Schistosoma mansoni opsin-like receptor 0.0025 0.001 0.0011
Brugia malayi Associated with TFs and helicases family protein 0.0026 0.0014 0.0013
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0097 0.0181 0.0184
Schistosoma mansoni neuropeptide receptor 0.0025 0.001 0.0011
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0044 0.0055 0.0048
Schistosoma mansoni importin beta-1 0.0059 0.0092 0.0099
Loa Loa (eye worm) hypothetical protein 0.0038 0.0041 0.0153
Mycobacterium ulcerans glutaminase 0.0285 0.0628 0.0853
Schistosoma mansoni neuropeptide receptor 0.0025 0.001 0.0011
Trypanosoma brucei DNA polymerase eta, putative 0.0114 0.0221 0.2563
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0105 0.02 0.0197
Entamoeba histolytica hypothetical protein 0.0026 0.0014 0.0021
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0036 0.0183
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.001 0.0011
Trichomonas vaginalis glucosylceramidase, putative 0.0301 0.0664 0.3902
Schistosoma mansoni neuropeptide receptor 0.0025 0.001 0.0011
Schistosoma mansoni aldehyde dehydrogenase 0.0132 0.0264 0.0284
Trypanosoma cruzi DNA repair protein, putative 0.0035 0.0033 0.0248
Loa Loa (eye worm) hypothetical protein 0.0216 0.0463 0.1742
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0037
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0368 0.0825 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0036 0.0037 0.0027
Echinococcus multilocularis neuropeptide receptor A26 0.1092 0.2542 0.2534
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0037 0.0296
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0121 0.011
Trichomonas vaginalis antibiotic synthetase, putative 0.0044 0.0055 0.0245
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0016 0.0011
Schistosoma mansoni BC026374 protein (S09 family) 0.0193 0.0408 0.044
Schistosoma mansoni integrin alpha-ps 0.0071 0.0121 0.013
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0037 0.0029
Treponema pallidum fructose-bisphosphate aldolase 0.0601 0.1377 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0044 0.0055 0.0918
Brugia malayi RNA, U transporter 1 0.0168 0.0351 0.1287
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0193 0.0408 0.0447
Brugia malayi ImpB/MucB/SamB family protein 0.0084 0.0151 0.0533
Schistosoma mansoni hypothetical protein 0.0025 0.001 0.0011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0283 0.0622 0.0671
Onchocerca volvulus 0.0044 0.0055 0.0265
Echinococcus multilocularis pyruvate kinase 0.0036 0.0037 0.0027
Brugia malayi Carboxylesterase family protein 0.0193 0.0408 0.1503
Echinococcus multilocularis protein dispatched 1 0.0097 0.0181 0.0171
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0036 0.0037 0.004
Trypanosoma cruzi trypanothione reductase, putative 0.0105 0.02 0.2299
Brugia malayi glutaminase DH11.1 0.0285 0.0628 0.2335
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0044 0.0055 0.0065
Schistosoma mansoni biogenic amine (5HT) receptor 0.0025 0.001 0.0011
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0099 0.0186 0.0176
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.3065 0.7222 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0025 0.001 0.0011
Loa Loa (eye worm) hypothetical protein 0.0033 0.0028 0.0104
Mycobacterium ulcerans beta-lactamase 0.0071 0.0121 0.0149
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0216 0.0463 0.0499
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0025 0.001 0.0011
Mycobacterium ulcerans dehydrogenase 0.0216 0.0463 0.0624
Schistosoma mansoni ap endonuclease 0.0057 0.0086 0.0093
Treponema pallidum recombinase A 0.0113 0.0218 0.1351
Schistosoma mansoni tar DNA-binding protein 0.0147 0.03 0.0323
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0037
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0126 0.0251 0.0943
Mycobacterium ulcerans aldehyde dehydrogenase 0.0132 0.0264 0.0347
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0037
Echinococcus multilocularis geminin 0.0693 0.1595 0.1586
Echinococcus granulosus glycine receptor subunit beta 0.0071 0.0119 0.0117
Leishmania major pyruvate kinase 0.0036 0.0037 0.0292
Giardia lamblia Kinase, PLK 0.0208 0.0444 0.3158
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0036 0.0037 0.0296
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0037
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0044 0.0055 0.0167
Echinococcus granulosus Chromo domain 0.0026 0.0014 0.0004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.001 0.0011
Echinococcus multilocularis tar DNA binding protein 0.0147 0.03 0.029
Loa Loa (eye worm) hypothetical protein 0.0071 0.0121 0.0451
Mycobacterium ulcerans DNA polymerase IV 0.0084 0.0151 0.0192
Schistosoma mansoni hypothetical protein 0.0082 0.0145 0.0157
Echinococcus granulosus Niemann Pick C1 protein 0.0198 0.0421 0.0443
Schistosoma mansoni amine oxidase 0.0216 0.0463 0.0499
Loa Loa (eye worm) hypothetical protein 0.0026 0.0014 0.005
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0266 0.0582 0.0656
Mycobacterium tuberculosis Carboxylesterase LipT 0.0193 0.0408 0.0447
Brugia malayi ImpB/MucB/SamB family protein 0.0114 0.0221 0.0797
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0153 0.0833
Leishmania major acetyl-CoA synthetase, putative 0.0044 0.0055 0.0511
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0037 0.0296
Schistosoma mansoni amine GPCR 0.0025 0.001 0.0011
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0456 0.1034 0.12
Brugia malayi latrophilin 2 splice variant baaae 0.0286 0.0629 0.2337
Mycobacterium ulcerans phytoene synthase, CrtB 0.0083 0.0149 0.0188
Brugia malayi hypothetical protein 0.0033 0.0028 0.0068
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0151 0.1702
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0057 0.0086 0.09
Echinococcus multilocularis GPCR, family 2 0.0132 0.0265 0.0255
Loa Loa (eye worm) hypothetical protein 0.0033 0.0028 0.0104
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0121 0.013
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0037 0.0296
Trichomonas vaginalis glutathione reductase, putative 0.0036 0.0037 0.014
Loa Loa (eye worm) hypothetical protein 0.114 0.2656 1
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0121 0.064
Schistosoma mansoni acetylcholine receptor-related 0.0033 0.0028 0.0031
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0036 0.0037 0.0102
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0071 0.0119 0.0445
Schistosoma mansoni pyruvate kinase 0.0036 0.0037 0.004
Onchocerca volvulus 0.0193 0.0408 0.2381
Loa Loa (eye worm) hypothetical protein 0.0026 0.0014 0.005
Treponema pallidum replicative DNA helicase (dnaB) 0.0403 0.0908 0.6499
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.114 0.2656 0.2862
Brugia malayi Cation transporter family protein 0.0071 0.0119 0.0409
Mycobacterium ulcerans aldehyde dehydrogenase 0.0132 0.0264 0.0347
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0033 0.0028 0.0068
Brugia malayi CHD4 protein 0.0035 0.0035 0.0092
Loa Loa (eye worm) hypothetical protein 0.0071 0.0119 0.0445
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0177 0.0372 0.039
Toxoplasma gondii NADPH-glutathione reductase 0.0036 0.0037 0.0489
Echinococcus granulosus cpg binding protein 0.0129 0.0257 0.0266
Mycobacterium leprae Probable lipase LipE 0.0071 0.0121 0.0305
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.013 0.2604
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0033 0.0028 0.0104
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.014 0.0284 0.0274
Onchocerca volvulus 0.0071 0.0119 0.0649
Onchocerca volvulus 0.005 0.0071 0.036
Loa Loa (eye worm) hypothetical protein 0.0033 0.0028 0.0104
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0089 0.0936
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0294 0.0648 0.2233
Trypanosoma brucei PAB1-binding protein , putative 0.0076 0.013 0.1444
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0037 0.0027
Brugia malayi AMP-binding enzyme family protein 0.0044 0.0055 0.0167
Echinococcus multilocularis peregrin 0.0032 0.0027 0.0016
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0032 0.0023
Schistosoma mansoni zinc finger protein 0.0027 0.0014 0.0016
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0601 0.1377 0.8181
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0071 0.0119 0.0108
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0239 0.0519 0.058
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0037
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0266 0.0582 0.1992
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0057 0.0086 0.0059
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0067 0.0111 0.0108
Loa Loa (eye worm) hypothetical protein 0.0091 0.0166 0.0623
Brugia malayi jmjC domain containing protein 0.0097 0.0181 0.0643
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0057 0.0086 0.0322
Trypanosoma cruzi trypanothione reductase, putative 0.0036 0.0037 0.0296
Loa Loa (eye worm) hypothetical protein 0.0041 0.0049 0.0182
Schistosoma mansoni growth hormone secretagogue receptor 0.0025 0.001 0.0011
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0054 0.0079 0.0388
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0025 0.001 0.0011
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0036 0.0026
Echinococcus multilocularis integrin alpha 3 0.0122 0.0241 0.0231
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0403 0.0908 0.3184
Schistosoma mansoni neuropeptide f receptor 76f 0.0025 0.001 0.0011
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0113 0.0218 0.0663
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0026 0.0014 0.0013
Loa Loa (eye worm) G-protein coupled receptor 0.0025 0.001 0.0037
Schistosoma mansoni hypothetical protein 0.0034 0.0032 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0103 0.0537
Echinococcus multilocularis acetylcholinesterase 0.114 0.2656 0.2648
Loa Loa (eye worm) helicase 0.0026 0.0014 0.005
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0044 0.0055 0.0844
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0037
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0014 0.0014
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0041 0.0049 0.0208
Schistosoma mansoni neurotransmitter gated ion channel 0.0038 0.0041 0.0045
Trichomonas vaginalis importin beta-1, putative 0.0048 0.0065 0.0307
Loa Loa (eye worm) hypothetical protein 0.0111 0.0215 0.0806
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0121 0.0305
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0044 0.0055 0.0204
Schistosoma mansoni neuropeptide receptor 0.0025 0.001 0.0011
Schistosoma mansoni acetyl-CoA synthetase 0.0044 0.0055 0.0059
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0105 0.02 0.0196
Onchocerca volvulus 0.0071 0.0119 0.0649
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0086 0.1623
Loa Loa (eye worm) hypothetical protein 0.0072 0.0121 0.0453
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0071 0.0119 0.0117
Loa Loa (eye worm) oxidoreductase 0.0044 0.0055 0.0204
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.0055 0.0058
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0403 0.0908 1
Leishmania major DNA polymerase eta, putative 0.0114 0.0221 0.2563
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0601 0.1377 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.0055 0.0058
Schistosoma mansoni hypothetical protein 0.0025 0.001 0.0011
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0071 0.0119 0.0108
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0044 0.0055 0.0044
Loa Loa (eye worm) carboxylesterase 0.114 0.2656 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0025 0.001 0.0037
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0132 0.0265 0.0255
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0071 0.0119 0.0108
Echinococcus granulosus Protein patched homolog 1 0.0085 0.0153 0.0154
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0121 0.0237 0.0858
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.001 0.0011
Mycobacterium tuberculosis Conserved protein 0.0071 0.0121 0.0101
Loa Loa (eye worm) hypothetical protein 0.0111 0.0215 0.0806
Schistosoma mansoni amidase 0.0099 0.0186 0.0201
Echinococcus granulosus zinc finger protein 0.0027 0.0014 0.0004
Plasmodium vivax hypothetical protein, conserved 0.003 0.0021 0.0176
Trypanosoma cruzi DNA polymerase kappa, putative 0.0084 0.0151 0.1702
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.0037 0.0482
Loa Loa (eye worm) hypothetical protein 0.0286 0.0629 0.2366
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.0419 0.2431
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0037
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0283 0.0622 0.0613
Plasmodium falciparum protoporphyrinogen oxidase 0.0216 0.0463 1
Schistosoma mansoni amine GPCR 0.0025 0.001 0.0011
Echinococcus granulosus sterol regulatory element binding protein 0.0085 0.0153 0.0154
Onchocerca volvulus 0.0044 0.0055 0.0265
Brugia malayi hypothetical protein 0.0177 0.0372 0.1366
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0044 0.0055 0.0021
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0121 0.0416
Loa Loa (eye worm) CXXC zinc finger family protein 0.012 0.0236 0.0887
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0033 0.0028 0.0068
Echinococcus multilocularis importin subunit beta 1 0.0059 0.0092 0.0081
Loa Loa (eye worm) hypothetical protein 0.0071 0.0119 0.0445
Trypanosoma brucei DNA polymerase IV, putative 0.0084 0.0151 0.1702
Loa Loa (eye worm) hypothetical protein 0.0033 0.0028 0.0104
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0071 0.0119 0.0409
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0151 0.1702
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0071 0.0119 0.0117
Brugia malayi glutathione reductase 0.0105 0.02 0.0716
Brugia malayi chromobox protein homolog 3 0.0091 0.0166 0.0589
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0026 0.0014 0.0013
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0201 0.0428 0.0462
Loa Loa (eye worm) hypothetical protein 0.0037 0.0039 0.0146
Loa Loa (eye worm) hypothetical protein 0.0051 0.0071 0.0266
Brugia malayi Carboxylesterase family protein 0.0193 0.0408 0.1503
Echinococcus multilocularis pyruvate kinase 0.0029 0.0019 0.0008
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0037 0.0159
Schistosoma mansoni hypothetical protein 0.0177 0.0372 0.0401
Schistosoma mansoni chromobox protein 0.0026 0.0014 0.0015
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0044 0.0055 0.0844
Loa Loa (eye worm) hypothetical protein 0.0026 0.0014 0.005
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0094 0.0175 0.0164
Loa Loa (eye worm) hypothetical protein 0.0212 0.0454 0.1706
Schistosoma mansoni adenoreceptor 0.0025 0.001 0.0011
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0121 0.0101
Schistosoma mansoni hypothetical protein 0.0083 0.0149 0.016
Loa Loa (eye worm) hypothetical protein 0.0149 0.0304 0.1142
Onchocerca volvulus 0.0071 0.0121 0.0659
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0033 0.0028 0.0068
Loa Loa (eye worm) jmjC domain-containing protein 0.0045 0.0057 0.0211
Loa Loa (eye worm) hypothetical protein 0.0033 0.0028 0.0104
Loa Loa (eye worm) acetylcholine receptor protein 0.0033 0.0028 0.0104
Trichomonas vaginalis CAMK family protein kinase 0.0208 0.0444 0.2581
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0044 0.0055 0.0021
Trichomonas vaginalis glucosylceramidase, putative 0.0208 0.0444 0.2582
Echinococcus multilocularis 0.0216 0.0463 0.0453
Schistosoma mansoni serine/threonine protein kinase 0.0208 0.0444 0.0479
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0036 0.0037 0.0033
Trypanosoma brucei unspecified product 0.0058 0.0089 0.0936
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0037
Giardia lamblia Pyruvate kinase 0.0036 0.0037 0.0174
Loa Loa (eye worm) hypothetical protein 0.0026 0.0014 0.005
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0056 0.0083 0.1421
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0016 0.0011
Echinococcus granulosus geminin 0.0693 0.1595 0.1709
Schistosoma mansoni aldehyde dehydrogenase 0.0132 0.0264 0.0284
Trichomonas vaginalis glucosylceramidase, putative 0.0301 0.0664 0.3902
Loa Loa (eye worm) hypothetical protein 0.0132 0.0265 0.0995
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0021 0.0023
Mycobacterium ulcerans acyl-CoA synthetase 0.0149 0.0304 0.0403
Loa Loa (eye worm) integrin alpha pat-2 0.0246 0.0534 0.201
Trypanosoma cruzi squalene synthase, putative 0.0267 0.0585 0.7051
Schistosoma mansoni glutaminase 0.0285 0.0628 0.0677
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.014 0.0284 0.1067
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0044 0.0055 0.0021
Brugia malayi AMP-binding enzyme family protein 0.0149 0.0304 0.111
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0025 0.001 0.0011
Plasmodium falciparum heterochromatin protein 1 0.0026 0.0014 0.0014
Toxoplasma gondii histone lysine-specific demethylase 0.0216 0.0463 0.9153
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.003 0.0023 0.0049
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0044 0.0055 0.0065
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0036 0.028
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0037 0.0296
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0036 0.0462
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0037
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0071 0.0119 0.0445
Schistosoma mansoni hypothetical protein 0.0026 0.0014 0.0015
Echinococcus granulosus dnaJ subfamily B 0.0895 0.2074 0.2226
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0025 0.001 0.0011
Loa Loa (eye worm) GABA receptor subunit 0.0038 0.0041 0.0153
Loa Loa (eye worm) TAR-binding protein 0.0147 0.03 0.1126
Brugia malayi hypothetical protein 0.0216 0.0463 0.1711
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.0055 0.0058
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.0419 0.2431
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0216 0.0463 0.1558
Schistosoma mansoni hypothetical protein 0.0632 0.1452 0.1565
Loa Loa (eye worm) hypothetical protein 0.0188 0.0398 0.1495
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.001 0.0011
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0036 0.0037 0.0534
Loa Loa (eye worm) glutathione reductase 0.0105 0.02 0.075
Mycobacterium tuberculosis Conserved hypothetical protein 0.0084 0.0151 0.0138
Onchocerca volvulus 0.0071 0.0121 0.0659
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.001 0.0011
Loa Loa (eye worm) melatonin receptor type 1A 0.0025 0.001 0.0037
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0041 0.0047 0.004
Echinococcus granulosus fatty acid amide hydrolase 1 0.0099 0.0186 0.019
Trypanosoma cruzi polo-like protein kinase, putative 0.0208 0.0444 0.5309
Plasmodium vivax hypothetical protein, conserved 0.0216 0.0463 1
Echinococcus multilocularis dna polymerase kappa 0.0084 0.0151 0.0141
Onchocerca volvulus 0.0071 0.0121 0.0659
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0113 0.0218 0.2079
Onchocerca volvulus 0.0071 0.012 0.0654
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0088 0.016 0.0162
Entamoeba histolytica hypothetical protein 0.0048 0.0065 0.0396
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0601 0.1377 0.8181
Onchocerca volvulus 0.0071 0.0119 0.0649
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0035 0.0035 0.0024
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0033 0.003 0.0019
Brugia malayi hypothetical protein 0.0076 0.013 0.0454
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0037 0.0296
Loa Loa (eye worm) neuropeptide F receptor 0.0025 0.001 0.0037
Schistosoma mansoni biogenic amine receptor 0.0025 0.001 0.0011
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0033 0.0028 0.0104
Schistosoma mansoni hypothetical protein 0.0034 0.0032 0.0035
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0025 0.001 0.0037
Schistosoma mansoni ap endonuclease 0.0057 0.0086 0.0093
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0014 0.0021
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.3537 0.8343 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0114 0.0221 0.2563
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0121 0.0101
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0057 0.0086 0.09
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0037
Loa Loa (eye worm) hypothetical protein 0.0111 0.0215 0.0806
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0151 0.1702
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0036 0.028
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0216 0.0463 0.0453
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.013 0.1444
Echinococcus granulosus lysosomal alpha glucosidase 0.0161 0.0334 0.0349
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0037 0.0137
Loa Loa (eye worm) hypothetical protein 0.0033 0.0028 0.0104
Echinococcus granulosus nAChR subunit 0.0071 0.0119 0.0117
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0132 0.0264 0.0273
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0036 0.0037 0.0296
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0044 0.0055 0.0058
Loa Loa (eye worm) twinkle helicase 0.0115 0.0225 0.0843
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0193 0.0408 0.0398
Trichomonas vaginalis CAMK family protein kinase 0.0208 0.0444 0.2581
Schistosoma mansoni jumonji/arid domain-containing protein 0.0045 0.0057 0.0061
Loa Loa (eye worm) hypothetical protein 0.0071 0.0119 0.0445
Echinococcus granulosus peregrin 0.0032 0.0027 0.0018
Plasmodium falciparum glutathione reductase 0.0036 0.0037 0.0534
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0037 0.0296
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0111 0.0215 0.0232
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0121 0.1322
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.001 0.0011
Echinococcus granulosus Squalene phytoene synthase 0.0083 0.0149 0.0149
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0071 0.0119 0.0409
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0601 0.1377 0.8181
Echinococcus granulosus nAChR subunit 0.0038 0.0041 0.0033
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0036 0.0133
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0037
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0036 0.0183
Loa Loa (eye worm) hypothetical protein 0.0193 0.0408 0.1534
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0121 0.064
Plasmodium vivax glutathione reductase, putative 0.0105 0.02 0.4147
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0037
Loa Loa (eye worm) hypothetical protein 0.0193 0.0408 0.1534
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0044 0.0055 0.0511
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0055 0.0509
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0021 0.0161
Schistosoma mansoni hypothetical protein 0.005 0.0071 0.0076
Loa Loa (eye worm) heterochromatin protein 1 0.0162 0.0335 0.1258
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0037
Schistosoma mansoni nAChR subunit 0.0071 0.0119 0.0128
Brugia malayi AMP-binding enzyme family protein 0.0044 0.0055 0.0167
Echinococcus granulosus calcium activated potassium channel variant 0.0043 0.0052 0.0045
Schistosoma mansoni DNA polymerase IV / kappa 0.0026 0.0013 0.0014
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0033 0.0028 0.0068
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0098 0.0183 0.103
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0216 0.0463 1
Onchocerca volvulus 0.0033 0.0028 0.0108
Echinococcus multilocularis Chromobox protein 3 0.0026 0.0014 0.0003
Loa Loa (eye worm) hypothetical protein 0.0033 0.0028 0.0104
Echinococcus granulosus pyruvate kinase 0.0036 0.0037 0.0029
Loa Loa (eye worm) hypothetical protein 0.0193 0.0408 0.1534
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0038 0.0041 0.0117
Loa Loa (eye worm) hypothetical protein 0.0071 0.0119 0.0445
Entamoeba histolytica acyl-CoA synthetase, putative 0.0149 0.0304 0.2145
Loa Loa (eye worm) hypothetical protein 0.0038 0.0041 0.0153
Schistosoma mansoni nAChR subunit 0.0071 0.0119 0.0128
Plasmodium vivax importin-beta 2, putative 0.0059 0.0092 0.1743
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0121 0.1322
Loa Loa (eye worm) hypothetical protein 0.0071 0.0119 0.0445
Schistosoma mansoni integrin alpha 0.0159 0.033 0.0355
Loa Loa (eye worm) hypothetical protein 0.0033 0.0028 0.0104
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0037
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0601 0.1377 0.8181
Loa Loa (eye worm) hypothetical protein 0.0126 0.0251 0.0943
Onchocerca volvulus 0.0026 0.0014 0.0021
Mycobacterium ulcerans lipase LipD 0.0071 0.0121 0.0149
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0632 0.1452 0.5465
Loa Loa (eye worm) hypothetical protein 0.0071 0.0119 0.0445
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.3246 0.7654 0.917
Brugia malayi Cation transporter family protein 0.0071 0.0119 0.0409
Loa Loa (eye worm) hypothetical protein 0.003 0.0021 0.0077
Onchocerca volvulus 0.0149 0.0304 0.1758
Schistosoma mansoni gliotactin 0.0193 0.0408 0.044
Chlamydia trachomatis recombinase RecA 0.0113 0.0218 0.2082
Loa Loa (eye worm) histone methyltransferase 0.0041 0.0047 0.0175
Echinococcus granulosus chromobox protein 1 0.0162 0.0335 0.035
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0057 0.0086 0.0551
Trichomonas vaginalis DNA polymerase eta, putative 0.0084 0.0151 0.0825
Echinococcus granulosus glycine receptor subunit alpha 1 0.0071 0.0119 0.0117
Schistosoma mansoni ran 0.0044 0.0055 0.0059
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0026 0.0014 0.0013
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0132 0.0265 0.0274
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0037
Onchocerca volvulus 0.0033 0.0028 0.0108
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0044 0.0055 0.0058
Brugia malayi AMP-binding enzyme family protein 0.0044 0.0055 0.0167
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0044 0.0055 0.0058
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0038 0.0041 0.0117
Loa Loa (eye worm) hypothetical protein 0.0099 0.0186 0.0699
Echinococcus multilocularis neuropeptide s receptor 0.1092 0.2542 0.2534
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0198 0.0421 0.3001
Brugia malayi beta-lactamase family protein 0.0071 0.0121 0.0416
Schistosoma mansoni cpg binding protein 0.0129 0.0257 0.0277
Echinococcus granulosus lysine specific histone demethylase 1A 0.0216 0.0463 0.0489
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0071 0.0119 0.0108
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0037
Plasmodium falciparum importin beta, putative 0.0059 0.0092 0.1743
Brugia malayi excitatory GABA receptor EXP-1A 0.0071 0.0119 0.0409
Schistosoma mansoni neuroligin 3 (S09 family) 0.0193 0.0408 0.044
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0037 0.0292
Echinococcus granulosus mixed lineage leukemia protein mll 0.0033 0.003 0.0021
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0033 0.0028 0.0018
Schistosoma mansoni hypothetical protein 0.0082 0.0145 0.0157
Echinococcus multilocularis zinc finger protein 0.0027 0.0014 0.0004
Schistosoma mansoni alpha glucosidase 0.0036 0.0036 0.0039
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0036 0.0037 0.0033
Plasmodium falciparum thioredoxin reductase 0.0036 0.0037 0.0534
Brugia malayi SWIRM domain containing protein 0.0216 0.0463 0.1711
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0283 0.0622 0.066
Trichomonas vaginalis helicase, putative 0.0027 0.0016 0.0011
Loa Loa (eye worm) hypothetical protein 0.0036 0.0037 0.0137
Brugia malayi amidase 0.0099 0.0186 0.0665
Loa Loa (eye worm) hypothetical protein 0.0033 0.0028 0.0104
Loa Loa (eye worm) hypothetical protein 0.0038 0.0041 0.0153
Brugia malayi SET domain containing protein 0.0032 0.0028 0.0067
Onchocerca volvulus 0.0038 0.0041 0.0186
Leishmania major hypothetical protein, conserved 0.0071 0.0121 0.1322
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.2849 0.671 0.8034
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0071 0.0119 0.0108
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0025 0.001 0.0011
Loa Loa (eye worm) hypothetical protein 0.0216 0.0463 0.1742
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0151 0.1702
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0147 0.03 0.1126
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0105 0.02 0.0197
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0026 0.0014 0.0014
Schistosoma mansoni tar DNA-binding protein 0.0147 0.03 0.0323
Trichomonas vaginalis CAMK family protein kinase 0.0208 0.0444 0.2581
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0037 0.0137
Loa Loa (eye worm) hypothetical protein 0.0368 0.0825 0.3104
Echinococcus granulosus para nitrobenzyl esterase 0.0193 0.0408 0.0429
Echinococcus granulosus integrin beta 2 0.0602 0.1379 0.1477
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0044 0.0055 0.0058
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0037 0.0296
Echinococcus multilocularis nAChR subunit 0.0038 0.0041 0.0031
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0037
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0037
Schistosoma mansoni nAChR subunit 0.0033 0.0028 0.0031
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0161 0.0334 0.1254
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0041 0.0047 0.0037
Echinococcus multilocularis integrin beta 2 0.0602 0.1379 0.137
Loa Loa (eye worm) hypothetical protein 0.0033 0.0028 0.0104
Onchocerca volvulus 0.0044 0.0055 0.0265
Loa Loa (eye worm) LGC-31 protein 0.0071 0.0119 0.0445
Schistosoma mansoni nAChR subunit 0.0071 0.0119 0.0128
Leishmania major DNA polymerase kappa, putative 0.0084 0.0151 0.1702
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0016 0.0011
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0283 0.0622 0.0613
Echinococcus multilocularis thioredoxin glutathione reductase 0.0105 0.02 0.019
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0021 0.0161
Leishmania major UDP-galactopyranose mutase 0.0216 0.0463 0.5544
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0033 0.0028 0.0019
Brugia malayi hypothetical protein 0.0033 0.0028 0.0068
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0037
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0084 0.0151 0.0138
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0096 0.0358
Mycobacterium ulcerans hypothetical protein 0.0149 0.0304 0.0403
Schistosoma mansoni jumonji/arid domain-containing protein 0.0045 0.0057 0.0061
Echinococcus granulosus integrin alpha ps 0.0071 0.0121 0.0119
Schistosoma mansoni hypothetical protein 0.0132 0.0265 0.0285
Loa Loa (eye worm) hypothetical protein 0.0193 0.0408 0.1534
Brugia malayi Latrophilin receptor protein 2 0.0132 0.0265 0.0961
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0037
Plasmodium vivax acetyl-CoA synthetase, putative 0.0044 0.0055 0.0922
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0049 0.0208
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0037 0.0138
Trypanosoma brucei trypanothione reductase 0.0105 0.02 0.2299
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.0419 0.2431
Giardia lamblia DINP protein human, muc B family 0.0084 0.0151 0.1013
Trichomonas vaginalis CAMK family protein kinase 0.0208 0.0444 0.2581
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0033 0.0028 0.0068
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0036 0.0133
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0026 0.0014 0.0015
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.0055 0.0058
Echinococcus multilocularis para nitrobenzyl esterase 0.0193 0.0408 0.0398
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0044 0.0055 0.0918
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0038 0.004 0.0004
Brugia malayi RNA binding protein 0.0147 0.03 0.1094
Trypanosoma brucei DNA polymerase IV, putative 0.0084 0.0151 0.1702
Loa Loa (eye worm) hypothetical protein 0.0121 0.0237 0.0891
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0037 0.0138
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0014 0.0021
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0193 0.0408 0.044
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0037
Schistosoma mansoni integrin beta subunit 0.0475 0.1079 0.1163
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0025 0.001 0.0011
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0043 0.0053 0.0057
Leishmania major pyruvate kinase 0.0036 0.0037 0.0292
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.0055 0.0058
Schistosoma mansoni nAChR subunit 0.0071 0.0119 0.0128
Echinococcus granulosus tar DNA binding protein 0.0147 0.03 0.0312
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0057 0.0086 0.0101
Brugia malayi amine oxidase, flavin-containing family protein 0.0216 0.0463 0.1711
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0086 0.0434
Loa Loa (eye worm) hypothetical protein 0.0149 0.0304 0.1142
Schistosoma mansoni microtubule-associated protein tau 0.3931 0.9278 1
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.0419 0.2431
Echinococcus multilocularis neuroligin 0.0193 0.0408 0.0398
Brugia malayi Cation transporter family protein 0.0071 0.0119 0.0409
Plasmodium falciparum glutathione reductase 0.0105 0.02 0.4147
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0071 0.0119 0.0128
Onchocerca volvulus 0.0193 0.0408 0.2381
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0037 0.0137
Loa Loa (eye worm) hypothetical protein 0.0033 0.0028 0.0104
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0044 0.0055 0.0021
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.014 0.0284 0.0295
Trypanosoma brucei squalene synthase, putative 0.0267 0.0585 0.7051
Loa Loa (eye worm) hypothetical protein 0.0071 0.0119 0.0445
Loa Loa (eye worm) hypothetical protein 0.0247 0.0537 0.2019
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0149 0.0304 0.0403
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0025 0.001 0.0037
Loa Loa (eye worm) hypothetical protein 0.0071 0.012 0.0448
Plasmodium falciparum pyruvate kinase 0.0036 0.0037 0.0527
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0036 0.0037 0.0004
Schistosoma mansoni calcium-activated potassium channel 0.0043 0.0052 0.0056
Schistosoma mansoni hypothetical protein 0.0132 0.0265 0.0285
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0094 0.0175 0.328
Echinococcus multilocularis integrin alpha ps 0.0034 0.0032 0.0022
Schistosoma mansoni neurotransmitter gated ion channel 0.0033 0.0028 0.0031
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0071 0.0119 0.0108
Mycobacterium tuberculosis Possible oxidoreductase 0.0216 0.0463 0.0513
Trypanosoma brucei C-8 sterol isomerase, putative 0.0368 0.0825 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0111 0.0215 0.448
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.001 0.0011
Entamoeba histolytica serine/threonine protein kinase, putative 0.0208 0.0444 0.317
Schistosoma mansoni hypothetical protein 0.0895 0.2074 0.2235
Trypanosoma cruzi DNA polymerase kappa, putative 0.0084 0.0151 0.1702
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0084 0.0151 0.1702
Echinococcus multilocularis glycine receptor subunit beta 0.0071 0.0119 0.0108
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0071 0.0119 0.0409
Brugia malayi polk-prov protein 0.0026 0.0013 0.0011
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0033 0.0028 0.0018
Trypanosoma brucei DNA polymerase IV, putative 0.0084 0.0151 0.1702
Schistosoma mansoni hypothetical protein 0.0693 0.1595 0.1719
Schistosoma mansoni opsin-like receptor 0.0025 0.001 0.0011
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.0037 0.0292
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0208 0.0444 0.0468
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0149 0.0304 0.0976
Echinococcus granulosus fetal alzheimer antigen falz 0.003 0.0022 0.0012
Loa Loa (eye worm) neuropeptide F receptor 0.0025 0.001 0.0037
Brugia malayi N-terminal motif family protein 0.0212 0.0454 0.1676
Entamoeba histolytica deoxycytidyl transferase, putative 0.0084 0.0151 0.1028
Trypanosoma brucei polo-like protein kinase 0.0208 0.0444 0.5309
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0084 0.0151 0.0825
Echinococcus granulosus thioredoxin glutathione reductase 0.0105 0.02 0.0204
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0193 0.0408 0.044
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0121 0.064
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0239 0.0519 0.176
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0089 0.0936
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0418 0.0943 0.3523
Brugia malayi Bromodomain containing protein 0.0039 0.0043 0.0124
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0283 0.0622 0.2313
Plasmodium vivax pyruvate kinase, putative 0.0036 0.0037 0.0527
Echinococcus granulosus fatty acid amide hydrolase 1 0.0099 0.0186 0.019
Mycobacterium ulcerans monoamine oxidase 0.0216 0.0463 0.0624
Loa Loa (eye worm) hypothetical protein 0.0216 0.0463 0.1742
Echinococcus multilocularis chromobox protein 2 0.0026 0.0014 0.0003
Trypanosoma cruzi DNA polymerase kappa, putative 0.0084 0.0151 0.1702
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0368 0.0825 0.3078
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0054 0.0079 0.0388
Mycobacterium ulcerans oxidoreductase 0.0216 0.0463 0.0624
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0044 0.0055 0.032
Brugia malayi Carboxylesterase family protein 0.114 0.2656 1
Echinococcus granulosus pyruvate kinase 0.0036 0.0037 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0091 0.0166 0.0914
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.0055 0.0058
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0054 0.0079 0.0388
Echinococcus granulosus carboxylesterase 5A 0.114 0.2656 0.2854
Trichomonas vaginalis CAMK family protein kinase 0.0208 0.0444 0.2581
Onchocerca volvulus Serine\/threonine kinase homolog 0.0208 0.0444 0.2597
Schistosoma mansoni ran 0.0044 0.0055 0.0059
Leishmania major C-8 sterol isomerase-like protein 0.0368 0.0825 1
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.3065 0.7222 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0601 0.1377 0.8181
Trypanosoma cruzi DNA repair protein, putative 0.0035 0.0033 0.0248
Schistosoma mansoni opsin-like receptor 0.0025 0.001 0.0011
Loa Loa (eye worm) hypothetical protein 0.0071 0.0119 0.0445
Schistosoma mansoni integrin alpha-ps 0.0037 0.0039 0.0043
Echinococcus granulosus lysine specific histone demethylase 1A 0.0216 0.0463 0.0489
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0037
Onchocerca volvulus Alhambra homolog 0.003 0.0021 0.0064
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0037
Onchocerca volvulus 0.0071 0.0119 0.0649
Loa Loa (eye worm) hypothetical protein 0.0114 0.0221 0.0831
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0037
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0301 0.0664 0.2471
Leishmania major 4-coumarate:coa ligase-like protein 0.0149 0.0304 0.3583
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.014 0.0284 0.0274
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.0083 0.0149 0.0135
Brugia malayi PHD-finger family protein 0.003 0.0021 0.0041
Onchocerca volvulus Putative nachr subunit 0.014 0.0284 0.1638
Echinococcus granulosus integrin alpha 3 0.0122 0.0241 0.0249
Loa Loa (eye worm) ACC-1 protein 0.0071 0.0119 0.0445
Loa Loa (eye worm) hypothetical protein 0.0026 0.0014 0.005
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0025 0.001 0.0011
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.014 0.0284 0.0295
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0032 0.0021
Schistosoma mansoni jumonji domain containing protein 0.0077 0.0133 0.0144
Schistosoma mansoni nAChR subunit 0.0071 0.0119 0.0128
Entamoeba histolytica hypothetical protein 0.0177 0.0372 0.2641
Echinococcus multilocularis potassium large conductance calcium activated 0.0046 0.006 0.0049
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0301 0.0664 0.2499
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0177 0.0372 0.0362
Echinococcus multilocularis calcium activated potassium channel variant 0.0043 0.0052 0.0042
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.0037 0.01
Entamoeba histolytica hypothetical protein 0.0026 0.0014 0.0021
Schistosoma mansoni chromobox protein 0.0162 0.0335 0.0361
Loa Loa (eye worm) hypothetical protein 0.0418 0.0943 0.3547
Echinococcus multilocularis snurportin 1 0.0632 0.1452 0.1443
Echinococcus granulosus GTP binding nuclear protein Ran 0.0044 0.0055 0.0048
Plasmodium vivax thioredoxin reductase, putative 0.0105 0.02 0.4147
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0044 0.0055 0.0511
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0193 0.0408 0.044
Schistosoma mansoni tar DNA-binding protein 0.0147 0.03 0.0323
Schistosoma mansoni hypothetical protein 0.0286 0.0629 0.0678
Loa Loa (eye worm) hypothetical protein 0.0193 0.0408 0.1534
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0071 0.0119 0.0445
Loa Loa (eye worm) hypothetical protein 0.0071 0.0121 0.0451
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0049 0.0038
Onchocerca volvulus 0.0038 0.0041 0.0186
Brugia malayi beta-lactamase family protein 0.0071 0.0121 0.0416
Echinococcus granulosus glycine receptor subunit beta 0.0071 0.0119 0.0117
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0111 0.0215 0.0214
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0044 0.0055 0.0204
Brugia malayi Carboxylesterase family protein 0.0193 0.0408 0.1503
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0071 0.0119 0.0409
Trichomonas vaginalis glucosylceramidase, putative 0.0208 0.0444 0.2582
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0121 0.0101
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0132 0.0265 0.0274
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0092 0.0966
Loa Loa (eye worm) hypothetical protein 0.0059 0.0092 0.0343
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0037 0.0159
Schistosoma mansoni neuropeptide F-like receptor 0.0025 0.001 0.0011
Onchocerca volvulus 0.0026 0.0014 0.0021
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0025 0.001 0.0011
Brugia malayi hypothetical protein 0.0247 0.0537 0.1989
Trichomonas vaginalis mercuric reductase, putative 0.0036 0.0037 0.014
Loa Loa (eye worm) hypothetical protein 0.003 0.0023 0.0085
Echinococcus multilocularis sterol regulatory element binding protein 0.0085 0.0153 0.0142
Onchocerca volvulus 0.012 0.0236 0.1352
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0021 0.0011
Echinococcus granulosus acetylcholinesterase 0.114 0.2656 0.2854
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0085 0.0153 0.0573
Trypanosoma cruzi UDP-galactopyranose mutase 0.0216 0.0463 0.5544
Loa Loa (eye worm) hypothetical protein 0.0071 0.0119 0.0445
Loa Loa (eye worm) hypothetical protein 0.0071 0.0119 0.0445
Schistosoma mansoni biogenic amine receptor 0.0025 0.001 0.0011
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.0334 0.0324
Loa Loa (eye worm) CHromoDomain protein family member 0.0035 0.0035 0.0128
Echinococcus multilocularis chromobox protein 1 0.0162 0.0335 0.0325
Loa Loa (eye worm) hypothetical protein 0.0071 0.0119 0.0445
Brugia malayi Bromodomain containing protein 0.0032 0.0027 0.0062
Loa Loa (eye worm) hypothetical protein 0.0071 0.0119 0.0445
Schistosoma mansoni histamine h1 receptor 0.0025 0.001 0.0011
Onchocerca volvulus Glucosylceramidase homolog 0.0197 0.0419 0.2446
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0037
Giardia lamblia Fructose-bisphosphate aldolase 0.0601 0.1377 1
Brugia malayi AMP-binding enzyme family protein 0.0149 0.0304 0.111
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0071 0.0119 0.0409
Loa Loa (eye worm) hypothetical protein 0.0038 0.0041 0.0153
Echinococcus granulosus survival motor neuron protein 1 0.0247 0.0537 0.0568
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0132 0.0265 0.0961
Echinococcus multilocularis pyruvate kinase 0.0036 0.0037 0.0027
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0044 0.0055 0.0511
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0025 0.001 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0016 0.0011
Mycobacterium ulcerans DNA polymerase IV 0.0084 0.0151 0.0192
Trichomonas vaginalis spcc417.12 protein, putative 0.0193 0.0408 0.2366
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0641 0.1471 0.5538
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0016 0.0011
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0037
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0026 0.0014 0.0014
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0044 0.0055 0.0511
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0151 0.1702
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0065 0.0307
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0121 0.0101
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0044 0.0055 0.0021
Schistosoma mansoni nAChR subunit 0.0071 0.0119 0.0128
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0193 0.0408 0.0447
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0036 0.0133
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0071 0.0119 0.0409
Schistosoma mansoni hypothetical protein 0.0132 0.0265 0.0285
Loa Loa (eye worm) MaxiK calcium-activated potassium channel 0.003 0.0023 0.0085
Leishmania major hypothetical protein, conserved 0.0076 0.013 0.1444
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0403 0.0908 0.1241
Mycobacterium ulcerans acyl-CoA synthetase 0.0149 0.0304 0.0403
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0036 0.0133
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0111 0.0215 0.028
Echinococcus granulosus snurportin 1 0.0632 0.1452 0.1555
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0121 0.0451
Onchocerca volvulus 0.0216 0.0463 0.2711
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0054 0.0079 0.0388
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0033 0.003 0.0021
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0121 0.0101
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.0055 0.0058
Trypanosoma cruzi phytoene synthase, putative 0.0083 0.0149 0.167
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0105 0.02 0.0197
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0283 0.0622 0.2341
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0037 0.0296
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0021 0.0077
Loa Loa (eye worm) hypothetical protein 0.0216 0.0463 0.1742
Schistosoma mansoni hypothetical protein 0.003 0.0021 0.0023
Loa Loa (eye worm) acetylcholinesterase 1 0.114 0.2656 1
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.0419 0.2431
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0037
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0038 0.0041 0.0117
Trichomonas vaginalis chromobox protein, putative 0.0098 0.0183 0.1012
Brugia malayi hypothetical protein 0.0033 0.0028 0.0068
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0054 0.0079 0.0388
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0036 0.0037 0.0029
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0094 0.0175 0.0188
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0216 0.0463 0.0499
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0057 0.0086 0.09
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0071 0.0119 0.0409
Schistosoma mansoni chromobox protein 0.0162 0.0335 0.0361
Loa Loa (eye worm) hypothetical protein 0.0026 0.0014 0.005
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0027 0.0014 0.0015
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0038 0.0041 0.0045
Loa Loa (eye worm) hypothetical protein 0.0193 0.0408 0.1534
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0044 0.0055 0.0058
Mycobacterium ulcerans aldehyde dehydrogenase 0.0132 0.0264 0.0347
Trypanosoma cruzi importin beta-1 subunit, putative 0.0048 0.0065 0.0639
Brugia malayi RNA recognition motif domain containing protein 0.0147 0.03 0.1094
Loa Loa (eye worm) hypothetical protein 0.0071 0.0119 0.0445
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0043 0.0052 0.0194
Mycobacterium ulcerans hypothetical protein 0.0071 0.0121 0.0149
Echinococcus granulosus expressed conserved protein 0.0186 0.0392 0.0412
Schistosoma mansoni kinase 0.0106 0.0202 0.0217
Echinococcus multilocularis Chromo domain 0.0026 0.0014 0.0003
Mycobacterium tuberculosis Probable reductase 0.0239 0.0519 0.058
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0097 0.0181 0.017
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.0083 0.0149 0.0829
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0149 0.0304 0.0976
Trichomonas vaginalis glucosylceramidase, putative 0.0301 0.0664 0.3902
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0208 0.0444 0.5309
Loa Loa (eye worm) hypothetical protein 0.0071 0.0119 0.0445
Echinococcus granulosus Niemann Pick C1 protein 0.0283 0.0623 0.066
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0071 0.0119 0.0128
Brugia malayi hypothetical protein 0.0193 0.0408 0.1503
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0121 0.0119
Schistosoma mansoni acetylcholinesterase 0.0193 0.0408 0.044
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0036 0.0037 0.0296
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0036 0.0037 0.0534
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0037 0.0296
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0149 0.0304 0.0322
Schistosoma mansoni fatty-acid amide hydrolase 0.0099 0.0186 0.0201
Brugia malayi hypothetical protein 0.0049 0.0067 0.0213
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0294 0.0648 0.088
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0121 0.0149
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.0419 0.2431
Onchocerca volvulus 0.0071 0.0119 0.0649
Brugia malayi Protein cec-1. 0.0026 0.0014 0.0013
Entamoeba histolytica acyl-coA synthetase, putative 0.0149 0.0304 0.2145
Trichomonas vaginalis CAMK family protein kinase 0.0208 0.0444 0.2581
Leishmania major 4-coumarate:coa ligase-like protein 0.0149 0.0304 0.3583
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.0055 0.0058
Toxoplasma gondii ABC1 family protein 0.0071 0.0121 0.2182
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0044 0.0055 0.084
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0044 0.0055 0.0021
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0037 0.0292
Leishmania major trypanothione reductase 0.0105 0.02 0.2299
Leishmania major acetyl-CoA synthetase, putative 0.0044 0.0055 0.0511
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0071 0.0119 0.0409
Brugia malayi Carboxylesterase family protein 0.114 0.2656 1
Echinococcus multilocularis survival motor neuron protein 1 0.0247 0.0537 0.0527
Echinococcus granulosus importin subunit beta 1 0.0059 0.0092 0.0088
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0035 0.0035 0.0026
Plasmodium vivax ataxin-2 like protein, putative 0.0076 0.013 0.2604
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0044 0.0055 0.0303
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.0419 0.2431
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0025 0.001 0.0011
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0035 0.0033 0.0248
Chlamydia trachomatis replicative DNA helicase 0.0403 0.0908 1
Toxoplasma gondii thioredoxin reductase 0.0105 0.02 0.3796
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0149 0.0304 0.0403
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0044 0.0055 0.0021
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0071 0.0119 0.0409
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0132 0.0265 0.0255
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0054 0.0079 0.0388
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.013 0.1444
Brugia malayi hypothetical protein 0.0033 0.0028 0.0068
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0026 0.0014 0.0015
Loa Loa (eye worm) carboxylesterase 0.0193 0.0408 0.1534
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0111 0.0215 0.0205
Brugia malayi TAR-binding protein 0.0147 0.03 0.1094
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0044 0.0055 0.0058
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0037
Schistosoma mansoni nAChR subunit 0.0071 0.0119 0.0128
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0036 0.0133
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0121 0.0237 0.0256
Brugia malayi hypothetical protein 0.0026 0.0014 0.0013
Trichomonas vaginalis glucosylceramidase, putative 0.0301 0.0664 0.3902
Loa Loa (eye worm) hypothetical protein 0.0076 0.013 0.0489
Schistosoma mansoni myosin xvIII 0.0025 0.001 0.0011
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0121 0.064
Trypanosoma cruzi DNA polymerase eta, putative 0.0056 0.0083 0.0861
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0195 0.1088
Echinococcus granulosus microtubule associated protein 2 0.3931 0.9278 1
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0049 0.0041
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0084 0.0151 0.0152
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0091 0.0166 0.0932
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0044 0.0055 0.0167
Loa Loa (eye worm) hypothetical protein 0.114 0.2656 1
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0016 0.0011
Toxoplasma gondii exonuclease III APE 0.0057 0.0086 0.1486
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0071 0.0227
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0026 0.0014 0.0015
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0216 0.0463 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0071 0.0119 0.0409
Echinococcus granulosus histone lysine methyltransferase setb 0.0111 0.0215 0.0221
Echinococcus multilocularis acetylcholinesterase 0.114 0.2656 0.2648
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0035 0.0035 0.0037
Loa Loa (eye worm) hypothetical protein 0.0071 0.0119 0.0445
Onchocerca volvulus 0.0071 0.0119 0.0649
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0044 0.0055 0.0065
Leishmania major 4-coumarate:coa ligase-like protein 0.0149 0.0304 0.3583
Loa Loa (eye worm) hypothetical protein 0.005 0.007 0.026
Plasmodium vivax SET domain protein, putative 0.0094 0.0175 0.3583
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0044 0.0055 0.0058
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0149 0.0304 0.0403
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.013 0.2604
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0086 0.1623
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0038 0.0041 0.0117
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0418 0.0943 0.3547
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0036 0.0133
Schistosoma mansoni tar DNA-binding protein 0.0147 0.03 0.0323
Leishmania major hypothetical protein, conserved 0.0083 0.0149 0.167
Loa Loa (eye worm) hypothetical protein 0.0088 0.016 0.0599
Schistosoma mansoni amine GPCR 0.0025 0.001 0.0011
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0036 0.0037 0.0489
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0026 0.0014 0.0003
Schistosoma mansoni patched 1 0.0085 0.0153 0.0165
Brugia malayi Pre-SET motif family protein 0.0094 0.0175 0.062
Onchocerca volvulus 0.0121 0.0237 0.1358
Brugia malayi serine/threonine-protein kinase plk-2 0.0208 0.0444 0.1639
Schistosoma mansoni Replicative DNA helicase 0.0403 0.0908 0.0979
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0223 0.0481 0.9507
Onchocerca volvulus 0.0729 0.168 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0239 0.0519 0.058
Mycobacterium ulcerans carboxylesterase, LipT 0.0193 0.0408 0.0548
Leishmania major squalene synthase, putative 0.0267 0.0585 0.7051
Loa Loa (eye worm) G-protein coupled receptor 0.0025 0.001 0.0037
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.0334 0.0324
Brugia malayi Integrin alpha pat-2 precursor 0.0159 0.033 0.1206
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0037
Echinococcus granulosus lysine specific demethylase 5A 0.0045 0.0057 0.005
Schistosoma mansoni pyruvate kinase 0.0036 0.0037 0.004
Echinococcus multilocularis dnaJ subfamily B 0.0895 0.2074 0.2065
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0037
Echinococcus granulosus GPCR family 2 0.0132 0.0265 0.0274
Brugia malayi hypothetical protein 0.0033 0.0028 0.0068
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0121 0.013
Echinococcus multilocularis nAChR subunit 0.0071 0.0119 0.0108
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0037
Toxoplasma gondii histone lysine methyltransferase SET1 0.0233 0.0505 1
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0071 0.0119 0.0445
Giardia lamblia NADH oxidase lateral transfer candidate 0.0036 0.0037 0.0176
Brugia malayi CHE-14 protein 0.0085 0.0153 0.0538
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0099 0.0186 0.0176
Giardia lamblia PHD finger protein 15 0.003 0.0021 0.0058
Brugia malayi Heterochromatin protein 1 0.0162 0.0335 0.1226
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0033 0.003 0.0019
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0065 0.0307
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0105 0.02 0.0197
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0044 0.0055 0.0509
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0193 0.0408 0.2366
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.0037 0.01
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.001 0.0011
Loa Loa (eye worm) hypothetical protein 0.0111 0.0215 0.0806
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0054 0.0079 0.0388
Plasmodium vivax heterochromatin protein 1, putative 0.0026 0.0014 0.0014
Brugia malayi Niemann-Pick C1 protein precursor 0.0198 0.0421 0.1552
Echinococcus granulosus glycine receptor subunit alpha 1 0.0071 0.0119 0.0117
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0071 0.0119 0.0117
Loa Loa (eye worm) RNA binding protein 0.0147 0.03 0.1126
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0111 0.0215 0.2042
Brugia malayi PHD-finger family protein 0.0032 0.0027 0.0063
Echinococcus granulosus BC026374 protein S09 family 0.0193 0.0408 0.0429
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0016 0.0011
Mycobacterium ulcerans pyruvate kinase 0.0036 0.0037 0.0033
Brugia malayi jmjC domain containing protein 0.0045 0.0057 0.0175
Schistosoma mansoni hypothetical protein 0.0025 0.001 0.0011
Schistosoma mansoni cpg binding protein 0.012 0.0236 0.0255
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0037
Schistosoma mansoni hypothetical protein 0.0693 0.1595 0.1719
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0283 0.0622 0.066
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0132 0.0264 0.3084
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0044 0.0055 0.0021
Schistosoma mansoni transcription factor LCR-F1 0.0177 0.0372 0.0401
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0084 0.0151 0.0163
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0037 0.0296
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0054 0.0079 0.0388
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0071 0.0119 0.0108
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0151 0.1702
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0216 0.0463 0.0624
Entamoeba histolytica hypothetical protein 0.0177 0.0372 0.2641
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0044 0.0055 0.0058
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0037
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0212 0.0454 0.2655
Leishmania major DNA polymerase eta, putative 0.0056 0.0083 0.0861
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0151 0.1702
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.001 0.0011
Brugia malayi Integrin beta pat-3 precursor 0.0817 0.1891 0.7108
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0111 0.0215 0.0232
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0086 0.0434
Brugia malayi AMP-binding enzyme family protein 0.0149 0.0304 0.111
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0036 0.0133
Loa Loa (eye worm) hypothetical protein 0.0085 0.0153 0.0573
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0089 0.0936
Loa Loa (eye worm) hypothetical protein 0.0033 0.0028 0.0104
Schistosoma mansoni hypothetical protein 0.0025 0.001 0.0011
Loa Loa (eye worm) hypothetical protein 0.0071 0.0121 0.0451
Echinococcus multilocularis Squalene phytoene synthase 0.0083 0.0149 0.0139
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0071 0.0119 0.0117
Loa Loa (eye worm) hypothetical protein 0.0071 0.0119 0.0445
Onchocerca volvulus 0.0193 0.0408 0.2381
Entamoeba histolytica hypothetical protein 0.0026 0.0014 0.0021
Leishmania major importin beta-1 subunit, putative 0.0048 0.0065 0.0639
Loa Loa (eye worm) hypothetical protein 0.0459 0.1041 0.3919
Loa Loa (eye worm) thioredoxin reductase 0.0105 0.02 0.075
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0026 0.0014 0.0004
Trypanosoma brucei unspecified product 0.0058 0.0089 0.0936
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0026 0.0014 0.0013
Mycobacterium leprae Conserved hypothetical protein 0.1189 0.2773 1
Toxoplasma gondii LsmAD domain-containing protein 0.0076 0.013 0.2384
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0132 0.0264 0.0253
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0103 0.0537
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0601 0.1377 0.8181
Brugia malayi hypothetical protein 0.0126 0.0251 0.091
Brugia malayi F/Y-rich N-terminus family protein 0.0052 0.0074 0.0239
Loa Loa (eye worm) hypothetical protein 0.0038 0.0041 0.0153
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0036 0.0037 0.0534
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0071 0.0119 0.0128
Brugia malayi exodeoxyribonuclease III family protein 0.0057 0.0086 0.0287
Schistosoma mansoni amine oxidase 0.0216 0.0463 0.0499
Loa Loa (eye worm) hypothetical protein 0.0038 0.0041 0.0153
Loa Loa (eye worm) hypothetical protein 0.0071 0.0121 0.0451
Entamoeba histolytica Ran family GTPase 0.0044 0.0055 0.0319
Echinococcus multilocularis integrin alpha ps 0.0071 0.0121 0.011
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0067 0.0111 0.01
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0071 0.0119 0.0128
Echinococcus multilocularis protoporphyrinogen oxidase 0.0216 0.0463 0.0453
Schistosoma mansoni hypothetical protein 0.0082 0.0145 0.0157
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0151 0.1702
Echinococcus granulosus dna polymerase kappa 0.0084 0.0151 0.0152
Trypanosoma cruzi DNA polymerase kappa, putative 0.0084 0.0151 0.1702
Echinococcus multilocularis carboxylesterase 5A 0.114 0.2656 0.2648
Plasmodium falciparum acyl-CoA synthetase 0.0111 0.0215 0.448
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0121 0.1322
Toxoplasma gondii aldehyde dehydrogenase 0.0132 0.0264 0.5092
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0033 0.0028 0.0019
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0601 0.1377 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0037 0.0296
Mycobacterium tuberculosis Probable oxidoreductase 0.0266 0.0582 0.0656
Loa Loa (eye worm) hypothetical protein 0.0044 0.0055 0.0204
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0239 0.0519 0.058
Onchocerca volvulus 0.0044 0.0055 0.0265
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0014 0.0021
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.014 0.0284 0.0295
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0057 0.0086 0.0535
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0057 0.0086 0.0563
Loa Loa (eye worm) hypothetical protein 0.0216 0.0463 0.1742
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0033 0.0028 0.0018
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0121 0.064
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0071 0.0119 0.0128
Schistosoma mansoni bromodomain containing protein 0.0071 0.0119 0.0129
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0071 0.0119 0.0409
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0044 0.0055 0.0021
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.014 0.0284 0.1034
Loa Loa (eye worm) carboxylesterase 0.0193 0.0408 0.1534
Echinococcus granulosus dna polymerase eta 0.0114 0.0221 0.0227
Echinococcus multilocularis cpg binding protein 0.0129 0.0257 0.0247
Loa Loa (eye worm) hypothetical protein 0.0038 0.0041 0.0153
Echinococcus multilocularis integrin alpha ps 0.0071 0.0121 0.011
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0037
Trypanosoma cruzi UDP-galactopyranose mutase 0.0216 0.0463 0.5544
Loa Loa (eye worm) hypothetical protein 0.0071 0.0121 0.0451
Schistosoma mansoni tar DNA-binding protein 0.0147 0.03 0.0323
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0283 0.0622 0.0671
Plasmodium falciparum phd finger protein, putative 0.003 0.0021 0.0176
Treponema pallidum exodeoxyribonuclease (exoA) 0.0057 0.0086 0.0366
Schistosoma mansoni hypothetical protein 0.0132 0.0265 0.0285
Loa Loa (eye worm) hypothetical protein 0.0039 0.0043 0.0161
Echinococcus granulosus integrin alpha ps 0.0034 0.0032 0.0024
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0149 0.0304 0.0322
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0071 0.0119 0.0128
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0037
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0071 0.0119 0.0409
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0057 0.0086 0.0076
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0037
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0057 0.0086 0.09
Mycobacterium ulcerans acyl-CoA synthetase 0.0149 0.0304 0.0403
Echinococcus granulosus calcium activated potassium channel 0.0046 0.0061 0.0055
Loa Loa (eye worm) hypothetical protein 0.0216 0.0463 0.1742
Loa Loa (eye worm) hypothetical protein 0.0198 0.0421 0.1583
Loa Loa (eye worm) hypothetical protein 0.0083 0.0149 0.0558
Loa Loa (eye worm) hypothetical protein 0.0459 0.1041 0.3919
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0037 0.0159
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0036 0.0037 0.0534
Schistosoma mansoni biogenic amine receptor 0.0025 0.001 0.0011
Schistosoma mansoni amine GPCR 0.0025 0.001 0.0011
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0037
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0014 0.0014
Mycobacterium tuberculosis Probable dehydrogenase 0.0239 0.0519 0.058
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0037 0.0296
Mycobacterium tuberculosis Conserved hypothetical protein 0.0216 0.0463 0.0513
Echinococcus multilocularis protein patched 0.0085 0.0153 0.0142
Trichomonas vaginalis chromobox protein, putative 0.0162 0.0335 0.1925
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0071 0.0119 0.0445
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0208 0.0444 0.0434
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0208 0.0444 0.167
Trypanosoma brucei pyruvate kinase 1 0.0036 0.0037 0.0292
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0037
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0044 0.0055 0.0044
Trichomonas vaginalis esterase, putative 0.0071 0.0121 0.064
Trichomonas vaginalis set domain proteins, putative 0.0729 0.168 1
Echinococcus granulosus Chromobox protein 3 0.0026 0.0014 0.0004
Loa Loa (eye worm) hypothetical protein 0.0033 0.0028 0.0104
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0016 0.0011
Echinococcus multilocularis Niemann Pick C1 protein 0.0283 0.0623 0.0613
Schistosoma mansoni chromobox protein 0.0026 0.0014 0.0015
Schistosoma mansoni cpg binding protein 0.0129 0.0257 0.0277
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0601 0.1377 0.8181
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0071 0.0119 0.0409
Loa Loa (eye worm) hypothetical protein 0.0104 0.0198 0.0743
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0036 0.0097
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0092 0.0966
Loa Loa (eye worm) hypothetical protein 0.0038 0.0041 0.0153
Mycobacterium tuberculosis Conserved protein 0.0071 0.0121 0.0101
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0151 0.1702
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0044 0.0055 0.0203
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0036 0.0026
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0195 0.1088
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0601 0.1377 0.8181
Schistosoma mansoni DNA polymerase eta 0.0114 0.0221 0.0238
Brugia malayi AMP-binding enzyme family protein 0.0044 0.0055 0.0167
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0121 0.2384
Trichomonas vaginalis antibiotic synthetase, putative 0.0044 0.0055 0.0245
Loa Loa (eye worm) hypothetical protein 0.0071 0.0119 0.0445
Loa Loa (eye worm) hypothetical protein 0.014 0.0284 0.1067
Echinococcus multilocularis expressed conserved protein 0.0186 0.0392 0.0382
Brugia malayi Kelch motif family protein 0.0126 0.0251 0.091
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0071 0.0119 0.0117
Loa Loa (eye worm) latrophilin receptor protein 2 0.0132 0.0265 0.0995
Trichomonas vaginalis glutaminase, putative 0.0285 0.0628 0.3685
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0132 0.0264 0.0273
Plasmodium vivax hypothetical protein, conserved 0.0216 0.0463 1
Schistosoma mansoni hypothetical protein 0.0082 0.0145 0.0157
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0044 0.0055 0.0511
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0044 0.0055 0.0021
Toxoplasma gondii propionate-CoA ligase 0.0044 0.0055 0.0844
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0216 0.0463 1
Schistosoma mansoni nAChR subunit 0.0033 0.0028 0.0031
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0283 0.0622 0.0671
Schistosoma mansoni neurotransmitter gated ion channel 0.0033 0.0028 0.0031
Loa Loa (eye worm) hypothetical protein 0.0125 0.0248 0.0932
Onchocerca volvulus 0.0193 0.0408 0.2381
Schistosoma mansoni alpha-1 adrenergic receptor 0.0025 0.001 0.0011
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0027 0.0014 0.0015
Loa Loa (eye worm) hypothetical protein 0.0193 0.0408 0.1534
Trichomonas vaginalis chromobox protein, putative 0.0162 0.0335 0.1925
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0016 0.0011
Echinococcus multilocularis glycine receptor subunit beta 0.0071 0.0119 0.0108
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0036 0.0133
Loa Loa (eye worm) hypothetical protein 0.0149 0.0304 0.1142
Trichomonas vaginalis conserved hypothetical protein 0.0091 0.0166 0.0914
Loa Loa (eye worm) hypothetical protein 0.0025 0.0011 0.0039
Echinococcus granulosus acetylcholinesterase 0.114 0.2656 0.2854
Brugia malayi Valyl-tRNA synthetase 0.0026 0.0014 0.0013
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0121 0.0101
Echinococcus granulosus chromobox protein 2 0.0026 0.0014 0.0004
Brugia malayi Pre-SET motif family protein 0.0641 0.1471 0.5522
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.014 0.0284 0.0274
Mycobacterium tuberculosis Conserved protein 0.0071 0.0121 0.0101
Entamoeba histolytica hypothetical protein 0.0038 0.0041 0.0223
Echinococcus multilocularis dna polymerase eta 0.0114 0.0221 0.0211
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0084 0.0151 0.0141
Echinococcus granulosus neuropeptide receptor A26 0.1092 0.2542 0.2732
Chlamydia trachomatis protoporphyrinogen oxidase 0.0216 0.0463 0.4893
Entamoeba histolytica hypothetical protein 0.0177 0.0372 0.2641
Brugia malayi Glycosyl hydrolases family 31 protein 0.0161 0.0334 0.1222
Brugia malayi Carboxylesterase family protein 0.0193 0.0408 0.1503
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0037
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0216 0.0463 1
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0071 0.0119 0.0409
Toxoplasma gondii HEAT repeat-containing protein 0.0059 0.0092 0.1595
Schistosoma mansoni amine GPCR 0.0025 0.001 0.0011
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0038 0.0041 0.0045
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0025 0.001 0.0037
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0044 0.0055 0.0922
Loa Loa (eye worm) hypothetical protein 0.0026 0.0013 0.0047
Loa Loa (eye worm) hypothetical protein 0.0033 0.0028 0.0104
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0037
Loa Loa (eye worm) hypothetical protein 0.0026 0.0014 0.005
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0033 0.0028 0.0068
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0021 0.0012
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0025 0.001 0.0037

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 132.9 nM Displacement of [125I]-echistatin from alphavbeta3 integrin receptor ChEMBL. 16302808
IC50 (binding) = 411.5 nM Displacement of [125I]-echistatin from alphavbeta5 integrin receptor ChEMBL. 16302808

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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