Detailed information for compound 1035897

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 462.455 | Formula: C25H33Cl2N3O
  • H donors: 1 H acceptors: 1 LogP: 5.59 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCN1CCN(CC1)C1=Nc2ccc(cc2CC=C1c1ccccc1)CCC.Cl.Cl
  • InChi: 1S/C25H31N3O.2ClH/c1-2-6-20-9-12-24-22(19-20)10-11-23(21-7-4-3-5-8-21)25(26-24)28-15-13-27(14-16-28)17-18-29;;/h3-5,7-9,11-12,19,29H,2,6,10,13-18H2,1H3;2*1H
  • InChiKey: JQIHVFKTJBCGKD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Huntingtin homolog 0.0119 0.1101 0.2907
Loa Loa (eye worm) amino acid permease 0.004 0.0201 0.0488
Loa Loa (eye worm) hypothetical protein 0.0031 0.0097 0.0199
Onchocerca volvulus 0.0051 0.0329 0.0165
Loa Loa (eye worm) pax transcription factor protein 2 0.0246 0.2563 0.7092
Trypanosoma brucei heat shock protein, putative 0.0032 0.0105 0.0856
Toxoplasma gondii ABC1 family protein 0.0074 0.0586 0.4718
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0105 0.1062
Echinococcus multilocularis expressed conserved protein 0.0102 0.0916 0.0888
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0198 0.0168
Schistosoma mansoni heat shock protein 0.0032 0.0105 0.0045
Loa Loa (eye worm) hypothetical protein 0.0031 0.0097 0.0199
Echinococcus granulosus muscleblind protein 0.0306 0.3249 0.3228
Onchocerca volvulus 0.0054 0.0355 0.0257
Schistosoma mansoni hypothetical protein 0.0293 0.3098 0.3056
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0086 0.0277
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0372 0.12
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0055 0.0372 0.3168
Loa Loa (eye worm) hypothetical protein 0.0061 0.0442 0.1163
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.013 0.0099
Echinococcus granulosus GPCR family 2 0.0034 0.013 0.0099
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0198 0.2622
Schistosoma mansoni endoplasmin 0.0032 0.0105 0.0045
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0586 0.1086
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0586 0.1565
Brugia malayi Isocitrate dehydrogenase 0.0034 0.0127 0.0187
Loa Loa (eye worm) hypothetical protein 0.0232 0.2398 0.6632
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0105 0.1799
Loa Loa (eye worm) heat shock protein 90 0.0032 0.0105 0.0222
Onchocerca volvulus 0.0048 0.0296 0.0045
Echinococcus multilocularis tumor protein p63 0.033 0.3532 0.3511
Schistosoma mansoni tar DNA-binding protein 0.0337 0.3603 0.3564
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0581 0.1469
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0279 0.2943 0.2921
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0355 0.092
Schistosoma mansoni tar DNA-binding protein 0.0337 0.3603 0.3564
Echinococcus granulosus lamin dm0 0.0054 0.0355 0.0325
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0586 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0198 0.2622
Echinococcus multilocularis heat shock protein 0.0032 0.0105 0.0074
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1764 0.5693
Echinococcus granulosus expressed conserved protein 0.0102 0.0916 0.0888
Brugia malayi Pax transcription factor protein 2 0.0246 0.2563 0.7064
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0086 0.0277
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0127 0.2165
Schistosoma mansoni tar DNA-binding protein 0.0337 0.3603 0.3564
Loa Loa (eye worm) hypothetical protein 0.0061 0.0442 0.1163
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.013 0.0099
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0279 0.2943 0.2921
Echinococcus granulosus heat shock protein 0.0032 0.0105 0.0074
Toxoplasma gondii heat shock protein 90, putative 0.0032 0.0105 0.0404
Loa Loa (eye worm) hypothetical protein 0.0031 0.0097 0.0199
Entamoeba histolytica heat shock transcription factor, putative 0.0103 0.0924 0.9318
Schistosoma mansoni hypothetical protein 0.0045 0.0258 0.0199
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0034 0.0127 0.4819
Echinococcus granulosus heat shock protein 90 0.0032 0.0105 0.0074
Leishmania major heat shock protein 83-1 0.0032 0.0105 0.0898
Echinococcus multilocularis Niemann Pick C1 protein 0.0156 0.1529 0.1503
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0111 0.1012 0.0957
Schistosoma mansoni intermediate filament proteins 0.0054 0.0355 0.0297
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1873 0.6045
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0586 0.0556
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0586 0.1086
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0025 0.0031 0.0265
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0198 0.0327
Echinococcus multilocularis musashi 0.0054 0.0355 0.0325
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0586 0.1891
Loa Loa (eye worm) hypothetical protein 0.0074 0.0586 0.1565
Leishmania major heat shock protein 83-1 0.0032 0.0105 0.0898
Brugia malayi Amino acid permease family protein 0.003 0.0086 0.0071
Schistosoma mansoni hypothetical protein 0.0045 0.0258 0.0199
Trypanosoma cruzi heat shock protein 90, putative 0.0025 0.0031 0.0532
Leishmania major heat shock protein 83-1 0.0032 0.0105 0.0898
Loa Loa (eye worm) isocitrate dehydrogenase 0.0034 0.0127 0.0282
Echinococcus multilocularis protein patched 0.0047 0.0278 0.0247
Leishmania major heat shock protein 83-1 0.0032 0.0105 0.0898
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0586 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0279 0.2943 0.29
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0055 0.0372 0.2797
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0283 0.0628
Brugia malayi heat shock protein 90 0.0032 0.0105 0.0127
Loa Loa (eye worm) hypothetical protein 0.003 0.0086 0.0167
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0279 0.2943 0.8136
Loa Loa (eye worm) hypothetical protein 0.0074 0.0586 0.1565
Leishmania major heat shock protein 83-1 0.0032 0.0105 0.0898
Plasmodium falciparum heat shock protein 90 0.0032 0.0105 0.3263
Mycobacterium leprae Probable lipase LipE 0.0074 0.0586 1
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0269 0.2824 0.7822
Schistosoma mansoni patched 1 0.0047 0.0278 0.0219
Loa Loa (eye worm) hypothetical protein 0.0074 0.0586 0.1565
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0109 0.0992 1
Brugia malayi intermediate filament protein 0.0054 0.0355 0.0832
Echinococcus granulosus Protein patched homolog 1 0.0047 0.0278 0.0247
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.2398 0.2375
Schistosoma mansoni hypothetical protein 0.0894 1 1
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0086 0.0277
Echinococcus multilocularis cation chloride cotransporter 0.003 0.0086 0.0055
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0105 0.1062
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0105 0.0856
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.1174 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0201 0.0488
Echinococcus granulosus cation chloride cotransporter 0.003 0.0086 0.0055
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0337 0.3603 1
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.2824 0.9115
Loa Loa (eye worm) hypothetical protein 0.0026 0.0037 0.0031
Onchocerca volvulus Glucosylceramidase homolog 0.0176 0.1764 0.526
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0055 0.0372 0.6348
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0586 1
Schistosoma mansoni lamin 0.0054 0.0355 0.0297
Echinococcus multilocularis protein dispatched 1 0.0053 0.0354 0.0324
Giardia lamblia Heat shock protein HSP 90-alpha 0.0032 0.0105 0.2179
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0198 0.1998
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.013 0.0195
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0586 0.1086
Trypanosoma brucei heat shock protein, putative 0.0032 0.0105 0.0856
Echinococcus multilocularis sterol regulatory element binding protein 0.0047 0.0278 0.0247
Loa Loa (eye worm) endoplasmin 0.0032 0.0105 0.0222
Schistosoma mansoni hypothetical protein 0.0045 0.0258 0.0199
Echinococcus multilocularis muscleblind protein 1 0.0306 0.3249 0.3228
Trypanosoma brucei heat shock protein, putative 0.0032 0.0105 0.0856
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0031 0.0101
Trypanosoma brucei Heat shock protein 83, putative 0.0032 0.0105 0.0856
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0105 0.0856
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0279 0.2943 0.29
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1764 0.5693
Echinococcus multilocularis heat shock protein 90 0.0032 0.0105 0.0074
Loa Loa (eye worm) hypothetical protein 0.0054 0.0355 0.092
Loa Loa (eye worm) TAR-binding protein 0.0337 0.3603 1
Mycobacterium ulcerans lipase LipD 0.0074 0.0586 0.4854
Brugia malayi Muscleblind-like protein 0.0306 0.3249 0.9001
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0127 0.1264
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0586 0.0556
Brugia malayi solute carrier family 12 member 1 0.0081 0.0674 0.1733
Echinococcus multilocularis tar DNA binding protein 0.0337 0.3603 0.3583
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0279 0.2943 0.2921
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0127 0.0096
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0034 0.0127 0.2165
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0198 0.3384
Schistosoma mansoni survival motor neuron protein 0.0047 0.0283 0.0224
Onchocerca volvulus Heat shock factor protein 2 homolog 0.0103 0.0924 0.2279
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0125 0.1174 0.1146
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0278 0.0897
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0279 0.2943 0.29
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1764 0.5693
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0086 0.0277
Schistosoma mansoni cation chloride cotransporter 0.003 0.0086 0.0025
Onchocerca volvulus 0.0074 0.0586 0.1076
Echinococcus granulosus mitogen activated protein kinase 0.0055 0.0372 0.0342
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0034 0.0127 0.0096
Giardia lamblia Kinase, CMGC MAPK 0.0055 0.0372 1
Leishmania major heat shock protein 83-1 0.0032 0.0105 0.0898
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0034 0.0127 0.0067
Echinococcus granulosus lamin 0.0054 0.0355 0.0325
Leishmania major heat shock protein 83-1 0.0032 0.0105 0.0898
Loa Loa (eye worm) hypothetical protein 0.0109 0.0992 0.2701
Schistosoma mansoni heat shock protein 0.0032 0.0105 0.0045
Schistosoma mansoni tar DNA-binding protein 0.0337 0.3603 0.3564
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0586 0.1086
Loa Loa (eye worm) hypothetical protein 0.0074 0.0586 0.1565
Trypanosoma brucei heat shock protein, putative 0.0032 0.0105 0.0856
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0127 0.0096
Loa Loa (eye worm) hypothetical protein 0.0119 0.1101 0.3005
Trichomonas vaginalis cation chloride cotransporter, putative 0.003 0.0086 0.0277
Trichomonas vaginalis esterase, putative 0.0074 0.0586 0.1891
Loa Loa (eye worm) hypothetical protein 0.004 0.0201 0.0488
Mycobacterium ulcerans beta-lactamase 0.0074 0.0586 0.4854
Leishmania major heat shock protein 83-1 0.0032 0.0105 0.0898
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0296 0.0237
Entamoeba histolytica heat shock transcription factor, putative 0.0103 0.0924 0.9318
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0586 0.1891
Loa Loa (eye worm) hypothetical protein 0.0052 0.0339 0.0874
Trypanosoma cruzi heat shock protein 85, putative 0.0025 0.0031 0.0532
Entamoeba histolytica heat shock transcription factor, putative 0.0103 0.0924 0.9318
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.2824 0.9115
Brugia malayi hypothetical protein 0.0232 0.2398 0.6599
Echinococcus multilocularis mitogen activated protein kinase 3 0.0055 0.0372 0.0342
Mycobacterium tuberculosis Conserved protein 0.0074 0.0586 0.1086
Schistosoma mansoni hypothetical protein 0.0034 0.013 0.007
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.1174 1
Echinococcus granulosus tar DNA binding protein 0.0337 0.3603 0.3583
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0047 0.0278 0.0704
Toxoplasma gondii aldehyde dehydrogenase 0.0125 0.1174 1
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0586 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0055 0.0372 0.3168
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.2824 0.9115
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0355 0.092
Leishmania major heat shock protein 83-1 0.0032 0.0105 0.0898
Brugia malayi TAR-binding protein 0.0337 0.3603 1
Brugia malayi MAP kinase sur-1 0.0055 0.0372 0.0879
Leishmania major heat shock protein 83-1 0.0032 0.0105 0.0898
Schistosoma mansoni hypothetical protein 0.0073 0.0581 0.0523
Echinococcus multilocularis lamin 0.0054 0.0355 0.0325
Schistosoma mansoni aldehyde dehydrogenase 0.0125 0.1174 0.112
Schistosoma mansoni hypothetical protein 0.0297 0.3154 0.3112
Schistosoma mansoni tar DNA-binding protein 0.0337 0.3603 0.3564
Echinococcus multilocularis muscleblind protein 0.0306 0.3249 0.3228
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0586 0.1086
Brugia malayi CHE-14 protein 0.0047 0.0278 0.0613
Loa Loa (eye worm) hypothetical protein 0.0073 0.0581 0.1551
Loa Loa (eye worm) hypothetical protein 0.0074 0.0586 0.1565
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0198 0.064
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0034 0.0127 0.0096
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.097 0.2566
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0586 0.0529
Echinococcus granulosus Niemann Pick C1 protein 0.0109 0.0992 0.0964
Leishmania major heat shock protein 83-1 0.0032 0.0105 0.0898
Leishmania major heat shock protein 83-1 0.0032 0.0105 0.0898
Trypanosoma cruzi Heat shock protein 83, putative 0.0032 0.0105 0.1799
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0297 0.3154 0.8743
Leishmania major hypothetical protein, conserved 0.0074 0.0586 0.499
Loa Loa (eye worm) beta-lactamase 0.0074 0.0586 0.1565
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0586 0.1086
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0127 0.0096
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0127 0.0596
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0125 0.1174 0.1146
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1873 0.6045
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.1174 1
Trypanosoma brucei heat shock protein, putative 0.0032 0.0105 0.0856
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0125 0.1174 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.013 0.0099
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0105 0.034
Echinococcus granulosus protein will die slowly 0.0293 0.3098 0.3076
Trichomonas vaginalis WD repeat domain, putative 0.0293 0.3098 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0586 0.1483
Echinococcus granulosus sterol regulatory element binding protein 0.0047 0.0278 0.0247
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0674 0.2177
Loa Loa (eye worm) hypothetical protein 0.004 0.0201 0.0488
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0372 0.12
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1764 0.5693
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.007 0.0123
Brugia malayi Amino acid permease family protein 0.0061 0.0442 0.1077
Plasmodium vivax heat shock protein 86, putative 0.0032 0.0105 0.0856
Brugia malayi beta-lactamase family protein 0.0074 0.0586 0.1483
Schistosoma mansoni hypothetical protein 0.0894 1 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0399 0.1041
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.097 0.2566
Echinococcus granulosus solute carrier family 12 0.0061 0.0442 0.0412
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0372 0.12
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0034 0.0127 0.0187
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0055 0.0372 0.6348
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0372 0.6348
Echinococcus multilocularis protein will die slowly 0.0293 0.3098 0.3076
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0055 0.0372 0.5927
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0586 0.0529
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0372 0.12
Trypanosoma brucei protein kinase, putative 0.0055 0.0372 0.5927
Echinococcus granulosus snurportin 1 0.0297 0.3154 0.3132
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0198 0.064
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0105 0.1799
Schistosoma mansoni hypothetical protein 0.0047 0.0283 0.0224
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0034 0.0127 0.1264
Schistosoma mansoni hypothetical protein 0.0034 0.013 0.007
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1764 0.5693
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.007 0.0027
Echinococcus granulosus Niemann Pick C1 protein 0.0156 0.1529 0.1503
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0586 0.4854
Brugia malayi Hypothetical 112.3 kDa protein K02A2.3 in chromosome II 0.0061 0.0442 0.1077
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0105 0.1799
Brugia malayi RNA, U transporter 1 0.0079 0.065 0.1664
Toxoplasma gondii exonuclease III APE 0.004 0.0198 0.1237
Brugia malayi Latrophilin receptor protein 2 0.0034 0.013 0.0195
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0105 0.1799
Loa Loa (eye worm) hypothetical protein 0.004 0.0201 0.0488
Loa Loa (eye worm) hypothetical protein 0.0052 0.0339 0.0874
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0034 0.0127 0.1264
Echinococcus multilocularis mitogen activated protein kinase 0.0055 0.0372 0.0342
Loa Loa (eye worm) hypothetical protein 0.0306 0.3249 0.9011
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0586 0.1891
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0674 0.2177
Brugia malayi Will die slowly protein 0.0293 0.3098 0.8574
Mycobacterium tuberculosis Conserved protein 0.0074 0.0586 0.1086
Echinococcus granulosus tumor protein p63 0.033 0.3532 0.3511
Leishmania major heat shock protein 83-1 0.0032 0.0105 0.0898
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0198 0.1688
Trypanosoma brucei heat shock protein, putative 0.0032 0.0105 0.0856
Schistosoma mansoni ap endonuclease 0.004 0.0198 0.0139
Onchocerca volvulus 0.0054 0.0355 0.0257
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0198 0.0389
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0586 0.1891
Echinococcus multilocularis geminin 0.0894 1 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.006 0.0096
Mycobacterium ulcerans hypothetical protein 0.0074 0.0586 0.4854
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.013 0.0289
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0198 0.3384
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0674 0.2177
Leishmania major heat shock protein 83-1 0.0032 0.0105 0.0898
Echinococcus granulosus mitogen activated protein kinase 3 0.0055 0.0372 0.0342
Schistosoma mansoni hypothetical protein 0.0034 0.013 0.007
Brugia malayi beta-lactamase 0.0074 0.0586 0.1483
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0269 0.2824 0.78
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0586 1
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0571 0.1843
Schistosoma mansoni hypothetical protein 0.0034 0.013 0.007
Trypanosoma brucei heat shock protein, putative 0.0032 0.0105 0.0856
Schistosoma mansoni lamin 0.0054 0.0355 0.0297
Loa Loa (eye worm) hypothetical protein 0.0306 0.3249 0.9011
Brugia malayi RNA binding protein 0.0337 0.3603 1
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0127 0.0596
Onchocerca volvulus 0.0246 0.2563 0.81
Echinococcus multilocularis Niemann Pick C1 protein 0.0109 0.0992 0.0964
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.013 0.0099
Echinococcus granulosus intermediate filament protein 0.0054 0.0355 0.0325
Schistosoma mansoni solute carrier family 12 electroneutral k-cl cotransporter 0.0061 0.0442 0.0384
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0055 0.0372 0.0967
Brugia malayi RNA recognition motif domain containing protein 0.0337 0.3603 1
Brugia malayi HSF-type DNA-binding domain containing protein 0.0103 0.0924 0.2439
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0586 0.4854
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0586 0.1086
Echinococcus granulosus importin subunit beta 1 0.0028 0.006 0.0029
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0198 0.0481
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0037 0.0006
Brugia malayi Endoplasmin precursor 0.0032 0.0105 0.0127
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0198 1
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.2824 0.9115
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0586 0.1891
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0355 0.0832
Loa Loa (eye worm) hypothetical protein 0.0048 0.0296 0.0753
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.2824 0.9115
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0086 0.0277
Brugia malayi isocitrate dehydrogenase 0.0034 0.0127 0.0187
Echinococcus multilocularis snurportin 1 0.0297 0.3154 0.3132
Loa Loa (eye worm) hypothetical protein 0.0031 0.0097 0.0199
Schistosoma mansoni endoplasmin 0.0032 0.0105 0.0045
Loa Loa (eye worm) hypothetical protein 0.0061 0.0442 0.1163
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0372 0.0313
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0125 0.1174 0.2237
Loa Loa (eye worm) RNA binding protein 0.0337 0.3603 1
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.2398 0.2375
Loa Loa (eye worm) hypothetical protein 0.0053 0.0344 0.0889
Mycobacterium tuberculosis Conserved protein 0.0074 0.0586 0.1086
Onchocerca volvulus Huntingtin homolog 0.0119 0.1101 0.2907
Toxoplasma gondii heat shock protein HSP90 0.0032 0.0105 0.0404
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0198 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0339 0.0874
Mycobacterium tuberculosis Possible penicillin-binding protein 0.047 0.514 1
Schistosoma mansoni hypothetical protein 0.0045 0.0258 0.0199
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0031 0.0101
Leishmania major heat shock protein 83-1 0.0032 0.0105 0.0898
Brugia malayi Niemann-Pick C1 protein precursor 0.0109 0.0992 0.263
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.097 0.2638
Echinococcus multilocularis GPCR, family 2 0.0034 0.013 0.0099
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0279 0.2943 0.8153
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0037 0.0006
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1764 0.5693
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0198 0.0168
Loa Loa (eye worm) hypothetical protein 0.0119 0.1101 0.3005
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0198 0.4903
Echinococcus multilocularis isocitrate dehydrogenase 0.0034 0.0127 0.0096
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.2824 0.9115
Leishmania major heat shock protein 83-1 0.0032 0.0105 0.0898
Trypanosoma brucei heat shock protein, putative 0.0032 0.0105 0.0856
Trichomonas vaginalis cation chloride cotransporter, putative 0.003 0.0086 0.0277
Loa Loa (eye worm) hypothetical protein 0.0074 0.0586 0.1565
Loa Loa (eye worm) WD40 repeat protein 0.0293 0.3098 0.8588
Leishmania major heat shock protein 83-1 0.0032 0.0105 0.0898
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1764 0.5693
Loa Loa (eye worm) solute carrier family 12 member 1 0.006 0.0433 0.1137
Echinococcus multilocularis solute carrier family 12 0.0061 0.0442 0.0412
Loa Loa (eye worm) hypothetical protein 0.0034 0.013 0.0289
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0198 1
Onchocerca volvulus 0.0074 0.0586 0.1076
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0031 0.0101
Schistosoma mansoni aldehyde dehydrogenase 0.0125 0.1174 0.112
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0372 0.6348
Echinococcus multilocularis lamin dm0 0.0054 0.0355 0.0325
Schistosoma mansoni ap endonuclease 0.004 0.0198 0.0139
Brugia malayi beta-lactamase family protein 0.0074 0.0586 0.1483
Plasmodium vivax endoplasmin, putative 0.0032 0.0105 0.0856
Loa Loa (eye worm) hypothetical protein 0.0103 0.0924 0.2512
Brugia malayi hypothetical protein 0.0119 0.1101 0.2937
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0127 0.108
Loa Loa (eye worm) hypothetical protein 0.0107 0.097 0.2638
Onchocerca volvulus 0.0293 0.3098 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0278 0.0704
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0279 0.2943 0.2921
Onchocerca volvulus 0.0074 0.0586 0.1076
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0198 0.1462
Echinococcus multilocularis importin subunit beta 1 0.0028 0.006 0.0029

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) < 30 % Antiexploratory activity (EXPL) of mice determined by an antimex activity meter, 100 mg/kg of dose was administered perorally; No inhibition ChEMBL. 2891853
Inhibition (functional) < 30 % Antireserpine activity (RES) of mice after peroral administration of 100 mg/kg of compound; No inhibition ChEMBL. 2891853
Inhibition (functional) = 51 % Antitremorine activity(TRM) of mice after peroral administration of 100 mg/kg of compound; Moderate inhibition (51-71%) ChEMBL. 2891853

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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