TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 280.75 | Formula: C14H17ClN2O2
H donors: 1 H acceptors: 3 LogP: 2.52 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)CCCc1ccc(cc1)Cn1cncc1.Cl
InChi: 1S/C14H16N2O2.ClH/c17-14(18)3-1-2-12-4-6-13(7-5-12)10-16-9-8-15-11-16;/h4-9,11H,1-3,10H2,(H,17,18);1H
InChiKey: QXNMHOCELFOYGM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	thromboxane A synthase 1 (platelet)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	cytochrome P450, putative	thromboxane A synthase 1 (platelet)	534 aa	498 aa	21.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0149	0.4439	0.4398
Onchocerca volvulus		0.0056	0.1308	0.3533
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	0.0028	0.0383	0.0006
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.0324	0.0596
Plasmodium falciparum	acyl-CoA synthetase	0.0021	0.0144	0.0265
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0032	0.0511	0.0865
Brugia malayi	ORL1-like opioid receptor	0.0056	0.1308	0.2216
Echinococcus granulosus	rhodopsin orphan GPCR	0.0056	0.1308	0.2216
Onchocerca volvulus		0.0111	0.3177	0.8584
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0021	0.0144	0.0078
Mycobacterium ulcerans	hypothetical protein	0.0028	0.0381	0.0627
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Echinococcus granulosus	allatostatin A receptor	0.0056	0.1308	0.2216
Brugia malayi	Dopamine receptor protein 2	0.0056	0.1308	0.2216
Schistosoma mansoni	neuropeptide receptor	0.0056	0.1308	0.2615
Schistosoma mansoni	amine GPCR	0.0056	0.1308	0.2615
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Brugia malayi	Serotonin receptor	0.0056	0.1308	0.2216
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0022	0.0187	0.0187
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0056	0.1308	0.2615
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Brugia malayi	cytoplasmic intermediate filament protein	0.0017	0.0014	0.0024
Echinococcus granulosus	neuropeptide Y receptor	0.0056	0.1308	0.2216
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0022	0.0187	0.0317
Brugia malayi	sulfakinin receptor protein	0.0056	0.1308	0.2216
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Echinococcus granulosus	rhodopsin orphan GPCR	0.0056	0.1308	0.2216
Onchocerca volvulus		0.0056	0.1308	0.3533
Echinococcus granulosus	g protein coupled receptor	0.0056	0.1308	0.2216
Schistosoma mansoni	neuropeptide receptor	0.0056	0.1308	0.2615
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0149	0.4439	0.4439
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0043	0.0875	0.5959
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0511	0.0865
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0056	0.1308	0.2615
Echinococcus granulosus	sex peptide receptor	0.0056	0.1308	0.2216
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0315	1	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0056	0.1308	0.2216
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0056	0.1308	0.2216
Echinococcus granulosus	rhodopsin orphan GPCR	0.0056	0.1308	0.2216
Loa Loa (eye worm)	cytochrome P450 family protein	0.0019	0.0072	0.0123
Trypanosoma cruzi	cytochrome P450, putative	0.0019	0.0072	0.0072
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0056	0.1308	0.2615
Trichomonas vaginalis	alpha-glucosidase, putative	0.0043	0.0875	0.5959
Onchocerca volvulus		0.0056	0.1308	0.3533
Brugia malayi	thymidylate synthase	0.0127	0.3701	0.6273
Trichomonas vaginalis	ap endonuclease, putative	0.0022	0.0187	0.1275
Onchocerca volvulus		0.0056	0.1308	0.3533
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0056	0.1308	0.2216
Schistosoma mansoni	neuropeptide F-like receptor	0.0056	0.1308	0.2615
Schistosoma mansoni	opsin-like receptor	0.0056	0.1308	0.2615
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0082	0.2176	0.3687
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0144	0.0244
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0056	0.1308	0.2216
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0056	0.1308	0.2216
Brugia malayi	hypothetical protein	0.0056	0.1308	0.2216
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.0324	0.0596
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0324	0.0253
Schistosoma mansoni	amine GPCR	0.0056	0.1308	0.2615
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0324	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0043	0.0875	0.1483
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.006	0.1462	0.2688
Brugia malayi	putative neuropeptide receptor NPR1	0.0056	0.1308	0.2216
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.1569	0.1508
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0044	0.0926	0.086
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0056	0.1308	0.2615
Brugia malayi	G protein-coupled receptor	0.0056	0.1308	0.2216
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0056	0.1308	0.2615
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.006	0.1462	0.1462
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0056	0.1308	0.2615
Echinococcus multilocularis	neuropeptides capa receptor	0.0056	0.1308	0.2216
Echinococcus granulosus	orexin receptor type 2	0.0056	0.1308	0.2216
Echinococcus granulosus	tm gpcr rhodopsin	0.0056	0.1308	0.2216
Leishmania major	4-coumarate:coa ligase-like protein	0.0028	0.0381	0.0381
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0082	0.2176	1
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0082	0.2176	1
Echinococcus granulosus	G protein coupled receptor 139	0.0056	0.1308	0.2216
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Echinococcus granulosus	serotonin receptor	0.0056	0.1308	0.2216
Onchocerca volvulus		0.0127	0.3701	1
Brugia malayi	hypothetical protein	0.0056	0.1308	0.2216
Schistosoma mansoni	neuropeptide f receptor 76f	0.0056	0.1308	0.2615
Leishmania major	cathepsin L-like protease	0.0063	0.1569	0.1569
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.006	0.1468	0.1468
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.006	0.1462	0.1462
Brugia malayi	Dopamine receptor protein 1	0.0056	0.1308	0.2216
Echinococcus granulosus	g protein coupled receptor	0.0056	0.1308	0.2216
Brugia malayi	intermediate filament protein	0.0032	0.0511	0.0865
Onchocerca volvulus		0.0056	0.1308	0.3533
Onchocerca volvulus		0.0056	0.1308	0.3533
Brugia malayi	hypothetical protein	0.0056	0.1308	0.2216
Echinococcus multilocularis	neuropeptides capa receptor	0.0056	0.1308	0.2216
Echinococcus multilocularis	neuropeptide receptor	0.0056	0.1308	0.2216
Schistosoma mansoni	histamine h1 receptor	0.0056	0.1308	0.2615
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0315	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0056	0.1308	0.2216
Echinococcus granulosus	rhodopsin orphan GPCR	0.0056	0.1308	0.2216
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0056	0.1308	0.3533
Loa Loa (eye worm)	CYP4Cod1	0.0019	0.0072	0.0123
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.006	0.1462	0.1462
Echinococcus multilocularis	g protein coupled receptor	0.0056	0.1308	0.2216
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0044	0.0926	0.0926
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0324	0.0596
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0056	0.1308	0.2216
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0022	0.0187	0.0116
Schistosoma mansoni	lamin	0.0032	0.0511	0.1021
Loa Loa (eye worm)	thymidylate synthase	0.0127	0.3701	0.6273
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0179	0.5438	0.5438
Schistosoma mansoni	ap endonuclease	0.0022	0.0187	0.0374
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0056	0.1308	0.2216
Brugia malayi	hypothetical protein	0.006	0.1468	0.2488
Onchocerca volvulus		0.0056	0.1308	0.3533
Echinococcus multilocularis	lamin dm0	0.0032	0.0511	0.0865
Loa Loa (eye worm)	cytochrome P450 family protein	0.0019	0.0072	0.0123
Echinococcus multilocularis	neuropeptide Y receptor	0.0056	0.1308	0.2216
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0127	0.3701	0.7342
Echinococcus multilocularis	sex peptide receptor	0.0056	0.1308	0.2216
Brugia malayi	AMP-binding enzyme family protein	0.0028	0.0381	0.0646
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.1569	0.1508
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0193	0.59	1
Schistosoma mansoni	serine/threonine protein kinase	0.006	0.1462	0.2923
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0056	0.1308	0.2216
Onchocerca volvulus		0.0056	0.1308	0.3533
Echinococcus granulosus	neuropeptides capa receptor	0.0056	0.1308	0.2216
Onchocerca volvulus		0.0056	0.1308	0.3533
Echinococcus granulosus	lamin	0.0032	0.0511	0.0865
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0056	0.1308	0.2216
Echinococcus granulosus	g protein coupled receptor	0.0056	0.1308	0.2216
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0179	0.5438	1
Brugia malayi	AMP-binding enzyme family protein	0.0028	0.0381	0.0646
Brugia malayi	neuropeptide F receptor	0.0056	0.1308	0.2216
Mycobacterium ulcerans	acyl-CoA synthetase	0.0028	0.0381	0.0627
Trichomonas vaginalis	ap endonuclease, putative	0.0022	0.0187	0.1275
Brugia malayi	Melatonin receptor type 1A	0.0056	0.1308	0.2216
Echinococcus granulosus	neuropeptide receptor	0.0056	0.1308	0.2216
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0056	0.1308	0.2216
Brugia malayi	hypothetical protein	0.0026	0.0324	0.0549
Echinococcus multilocularis	orexin receptor type 2	0.0056	0.1308	0.2216
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Schistosoma mansoni	neuropeptide receptor	0.0056	0.1308	0.2615
Giardia lamblia	Kinase, CMGC MAPK	0.006	0.1462	1
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0043	0.0875	0.1483
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0056	0.1308	0.2216
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.0187	0.0344
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0021	0.0144	0.0145
Echinococcus multilocularis	serotonin receptor	0.0056	0.1308	0.2216
Echinococcus granulosus	g-protein coupled receptor	0.0056	0.1308	0.2216
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.1569	0.1508
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0056	0.1308	0.2615
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0056	0.1308	0.2216
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0144	0.0244
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0056	0.1308	0.2216
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0043	0.0875	0.1483
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0082	0.2176	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0056	0.1308	0.2216
Onchocerca volvulus		0.0028	0.0381	0.1031
Echinococcus granulosus	biogenic amine 5HT receptor	0.0056	0.1308	0.2216
Brugia malayi	G-protein coupled receptor	0.0056	0.1308	0.2216
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0044	0.0926	0.0926
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0082	0.2176	0.4265
Schistosoma mansoni	neuropeptide F-like receptor	0.0056	0.1308	0.2615
Brugia malayi	hypothetical protein	0.0017	0.0011	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0028	0.0381	0.0627
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0056	0.1308	0.2615
Echinococcus granulosus	neuropeptide s receptor	0.0056	0.1308	0.2216
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Trichomonas vaginalis	CMGC family protein kinase	0.006	0.1462	0.9956
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0028	0.0383	0.0705
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0082	0.2176	0.4001
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0043	0.0875	1
Leishmania major	cathepsin L-like protease	0.0063	0.1569	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Schistosoma mansoni	hypothetical protein	0.0056	0.1308	0.2615
Schistosoma mansoni	biogenic amine receptor	0.0056	0.1308	0.2615
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.006	0.1462	0.1462
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0056	0.1308	0.2216
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.006	0.1462	0.1399
Trypanosoma brucei	glucosidase, putative	0.0043	0.0875	0.0808
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0056	0.1308	0.2615
Echinococcus multilocularis	fmrfamide receptor	0.0056	0.1308	0.2216
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0193	0.59	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0028	0.0381	0.0563
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0028	0.0381	0.0627
Brugia malayi	exodeoxyribonuclease III family protein	0.0022	0.0187	0.0317
Trypanosoma cruzi	cysteine peptidase, putative	0.0063	0.1569	0.1569
Echinococcus granulosus	7tm_1 domain containing protein	0.0056	0.1308	0.2216
Schistosoma mansoni	intermediate filament proteins	0.0032	0.0511	0.1021
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0056	0.1308	0.2216
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0875	0.0875
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0056	0.1308	0.2216
Echinococcus granulosus	thymidylate synthase	0.0127	0.3701	0.6273
Echinococcus granulosus	neuropeptides capa receptor	0.0056	0.1308	0.2216
Loa Loa (eye worm)	dihydrofolate reductase	0.0052	0.1179	0.1997
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0324	0.0549
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0056	0.1308	0.2615
Echinococcus multilocularis	thymidylate synthase	0.0127	0.3701	0.6273
Brugia malayi	Serotonin receptor	0.0056	0.1308	0.2216
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0053	0.1234	0.2567
Echinococcus multilocularis	neuropeptide s receptor	0.0056	0.1308	0.2216
Schistosoma mansoni	hypothetical protein	0.0056	0.1308	0.2615
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Schistosoma mansoni	ap endonuclease	0.0022	0.0187	0.0374
Echinococcus granulosus	tm gpcr rhodopsin	0.0056	0.1308	0.2216
Schistosoma mansoni	neuropeptide receptor	0.0056	0.1308	0.2615
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Loa Loa (eye worm)	hypothetical protein	0.0082	0.2176	0.3687
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.0052	0.1179	0.2401
Trypanosoma cruzi	cruzipain precursor, putative	0.0063	0.1569	0.1569
Echinococcus multilocularis	dro:myosuppressin receptor	0.0056	0.1308	0.2216
Echinococcus multilocularis	g-protein coupled receptor	0.0056	0.1308	0.2216
Echinococcus multilocularis	musashi	0.0032	0.0511	0.0865
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0056	0.1308	0.2615
Schistosoma mansoni	growth hormone secretagogue receptor	0.0056	0.1308	0.2615
Trypanosoma brucei	protein kinase, putative	0.006	0.1462	0.1399
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.006	0.1462	0.2477
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0179	0.5438	0.5405
Onchocerca volvulus		0.0056	0.1308	0.3533
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Leishmania major	4-coumarate:coa ligase-like protein	0.0028	0.0381	0.0381
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.1569	0.1508
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0043	0.0875	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0043	0.0875	0.5959
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0149	0.4439	0.4439
Toxoplasma gondii	hypothetical protein	0.0028	0.0383	0.0705
Echinococcus granulosus	lysosomal alpha glucosidase	0.0193	0.59	1
Brugia malayi	Cytochrome P450 family protein	0.0019	0.0072	0.0123
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0017	0.0014	0.0024
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.1569	0.1508
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0144	0.0244
Schistosoma mansoni	myosin xvIII	0.0056	0.1308	0.2615
Echinococcus multilocularis	neuropeptide Y receptor	0.0056	0.1308	0.2216
Brugia malayi	larval opioid receptor	0.0056	0.1308	0.2216
Trypanosoma cruzi	cysteine peptidase, putative	0.0063	0.1569	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Schistosoma mansoni	amine GPCR	0.0056	0.1308	0.2615
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Onchocerca volvulus		0.0056	0.1308	0.3533
Schistosoma mansoni	alpha-glucosidase	0.0166	0.5001	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0056	0.1308	0.2216
Toxoplasma gondii	exonuclease III APE	0.0022	0.0187	0.0344
Trichomonas vaginalis	alpha-glucosidase, putative	0.0043	0.0875	0.5959
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0056	0.1308	0.2615
Leishmania major	cytochrome p450-like protein	0.0019	0.0072	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0043	0.0875	0.5959
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0491	0.0832
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0058	0.1385	0.1385
Brugia malayi	hypothetical protein	0.0056	0.1308	0.2216
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0324	0.0324
Schistosoma mansoni	alpha glucosidase	0.0043	0.0875	0.1749
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0056	0.1308	0.2216
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0056	0.1308	0.2216
Onchocerca volvulus		0.0056	0.1308	0.3533
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0082	0.2176	0.4001
Echinococcus multilocularis	somatostatin receptor	0.0056	0.1308	0.2216
Echinococcus granulosus	7TM GPCR rhodopsin	0.0056	0.1308	0.2216
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0144	0.0244
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0056	0.1308	0.2615
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0056	0.1308	0.2216
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Leishmania major	alpha glucosidase II subunit, putative	0.0043	0.0875	0.0875
Leishmania major	4-coumarate:coa ligase-like protein	0.0028	0.0381	0.0381
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0056	0.1308	0.2216
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.1569	0.1508
Echinococcus multilocularis	serotonin receptor	0.0056	0.1308	0.2216
Brugia malayi	Probable ClpP-like protease	0.0082	0.2176	0.3687
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0056	0.1308	0.2216
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0056	0.1308	0.2615
Echinococcus multilocularis	dihydrofolate reductase	0.0052	0.1179	0.1997
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0056	0.1308	0.2216
Echinococcus granulosus	biogenic amine 5HT receptor	0.0056	0.1308	0.2216
Brugia malayi	follicle stimulating hormone receptor	0.0056	0.1308	0.2216
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0056	0.1308	0.2216
Echinococcus granulosus	neuropeptide receptor	0.0056	0.1308	0.2216
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.006	0.1462	0.1462
Mycobacterium tuberculosis	Hypothetical protein	0.006	0.1468	0.2782
Schistosoma mansoni	opsin-like receptor	0.0056	0.1308	0.2615
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0056	0.1308	0.2216
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0053	0.1234	0.2303
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0022	0.0187	0.2139
Brugia malayi	hypothetical protein	0.0056	0.1308	0.2216
Loa Loa (eye worm)	G-protein coupled receptor	0.0056	0.1308	0.2216
Loa Loa (eye worm)	melatonin receptor type 1A	0.0056	0.1308	0.2216
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Schistosoma mansoni	dihydrofolate reductase	0.0052	0.1179	0.2357
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0043	0.0875	0.5959
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0056	0.1308	0.2216
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0056	0.1308	0.2615
Leishmania major	cathepsin L-like protease	0.0063	0.1569	0.1569
Loa Loa (eye worm)	TYRA-2 protein	0.0056	0.1308	0.2216
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0022	0.0187	0.0317
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0056	0.1308	0.2216
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0875	0.0875
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0028	0.0383	0.0988
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0056	0.1308	0.2615
Echinococcus granulosus	neuropeptide receptor A26	0.0056	0.1308	0.2216
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0043	0.0875	0.5959
Mycobacterium ulcerans	acyl-CoA synthetase	0.0028	0.0381	0.0627
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0056	0.1308	0.2216
Brugia malayi	neuropeptide F receptor	0.0056	0.1308	0.2216
Schistosoma mansoni	adenoreceptor	0.0056	0.1308	0.2615
Loa Loa (eye worm)	G-protein coupled receptor	0.0056	0.1308	0.2216
Mycobacterium ulcerans	hypothetical protein	0.0166	0.5003	1
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0193	0.59	1
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0179	0.5438	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0056	0.1308	0.2216
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0056	0.1308	0.2216
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0082	0.2176	0.4001
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Echinococcus granulosus	rhodopsin orphan GPCR	0.0056	0.1308	0.2216
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0324	0.0596
Schistosoma mansoni	biogenic amine receptor	0.0056	0.1308	0.2615
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.1569	0.1508
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0166	0.5003	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0056	0.1308	0.2216
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0056	0.1308	0.2216
Brugia malayi	Dopamine receptor	0.0056	0.1308	0.2216
Schistosoma mansoni	peptidase Clp (S14 family)	0.0082	0.2176	0.435
Brugia malayi	Intermediate filament tail domain containing protein	0.0032	0.0511	0.0865
Trichomonas vaginalis	CMGC family protein kinase	0.006	0.1462	0.9956
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0056	0.1308	0.2216
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0056	0.1308	0.2615
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0056	0.1308	0.2216
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.0052	0.1179	0.2243
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0028	0.0381	0.4361
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.1569	0.1508
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0053	0.1234	0.2091
Loa Loa (eye worm)	neuropeptide F receptor	0.0056	0.1308	0.2216
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0056	0.1308	0.2216
Schistosoma mansoni	amine GPCR	0.0056	0.1308	0.2615
Mycobacterium ulcerans	thymidylate synthase	0.0127	0.3701	0.736
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0028	0.0381	0.0627
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0056	0.1308	0.2216
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.1569	0.1508
Loa Loa (eye worm)	intermediate filament protein	0.0032	0.0511	0.0865
Schistosoma mansoni	opsin-like receptor	0.0056	0.1308	0.2615
Chlamydia trachomatis	dihydrofolate reductase	0.0052	0.1179	0.5093
Echinococcus granulosus	mitogen activated protein kinase 3	0.006	0.1462	0.2477
Brugia malayi	RE15519p	0.0056	0.1308	0.2216
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0054	0.1251	0.1251
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0056	0.1308	0.2615
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0056	0.1308	0.2615
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0056	0.1308	0.2216
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0022	0.0187	0.0187
Echinococcus granulosus	rhodopsin orphan GPCR	0.0056	0.1308	0.2216
Schistosoma mansoni	hypothetical protein	0.0056	0.1308	0.2615
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0082	0.2176	1
Onchocerca volvulus		0.0056	0.1308	0.3533
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.0052	0.1179	0.2191
Onchocerca volvulus		0.0056	0.1308	0.3533
Schistosoma mansoni	hypothetical protein	0.0056	0.1308	0.2615
Echinococcus multilocularis	neuropeptide receptor	0.0056	0.1308	0.2216
Echinococcus granulosus	somatostatin receptor	0.0056	0.1308	0.2216
Echinococcus granulosus	dro:myosuppressin receptor	0.0056	0.1308	0.2216
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Trichomonas vaginalis	alpha-glucosidase, putative	0.0043	0.0875	0.5959
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0056	0.1308	0.2216
Brugia malayi	MAP kinase sur-1	0.006	0.1462	0.2477
Brugia malayi	Dihydrofolate reductase	0.0052	0.1179	0.1997
Brugia malayi	GnHR receptor homolog	0.0056	0.1308	0.2216
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0381	0.0646
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0056	0.1308	0.2615
Mycobacterium ulcerans	acyl-CoA synthetase	0.0028	0.0381	0.0627
Echinococcus granulosus	tm gpcr rhodopsin	0.0056	0.1308	0.2216
Brugia malayi	hypothetical protein	0.0056	0.1308	0.2216
Trichomonas vaginalis	CMGC family protein kinase	0.006	0.1462	0.9956
Leishmania major	hypothetical protein, conserved	0.0026	0.0324	0.0324
Echinococcus granulosus	neuropeptide Y receptor	0.0056	0.1308	0.2216
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0381	0.0646
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.1569	0.1508
Onchocerca volvulus		0.0056	0.1308	0.3533
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0028	0.0383	0.0705
Trypanosoma cruzi	cysteine peptidase, putative	0.0063	0.1569	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0144	0.0244
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0056	0.1308	0.2216
Trichomonas vaginalis	alpha-glucosidase, putative	0.0043	0.0875	0.5959
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0056	0.1308	0.2615
Trichomonas vaginalis	CMGC family protein kinase	0.006	0.1462	0.9956
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0082	0.2176	0.4001
Echinococcus multilocularis	g protein coupled receptor	0.0056	0.1308	0.2216
Echinococcus granulosus	dihydrofolate reductase	0.0052	0.1179	0.1997
Brugia malayi	dihydrofolate reductase family protein	0.0052	0.1179	0.1997
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Echinococcus multilocularis	mitogen activated protein kinase	0.006	0.1462	0.2477
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0179	0.5438	0.5438
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0082	0.2176	0.5404
Brugia malayi	G-protein coupled receptor	0.0056	0.1308	0.2216
Echinococcus granulosus	lamin dm0	0.0032	0.0511	0.0865
Schistosoma mansoni	biogenic amine receptor	0.0056	0.1308	0.2615
Echinococcus granulosus	rhodopsin orphan GPCR	0.0056	0.1308	0.2216
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0022	0.0187	0.0167
Plasmodium vivax	acyl-CoA synthetase, putative	0.0021	0.0144	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Echinococcus multilocularis	G protein coupled receptor 139	0.0056	0.1308	0.2216
Echinococcus granulosus	hypothetical protein	0.0056	0.1308	0.2216
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0056	0.1308	0.2615
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0056	0.1308	0.2615
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0193	0.59	1
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Onchocerca volvulus		0.0056	0.1308	0.3533
Brugia malayi	hypothetical protein	0.0056	0.1308	0.2216
Brugia malayi	hypothetical protein	0.0056	0.1308	0.2216
Schistosoma mansoni	amine GPCR	0.0056	0.1308	0.2615
Onchocerca volvulus		0.0056	0.1308	0.3533
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0028	0.0381	0.0627
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0028	0.0381	0.4361
Echinococcus multilocularis	lamin	0.0032	0.0511	0.0865
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.0127	0.3701	1
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0053	0.1234	0.2303
Echinococcus multilocularis	fmrfamide receptor	0.0056	0.1308	0.2216
Echinococcus granulosus	fmrfamide receptor	0.0056	0.1308	0.2216
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0043	0.0875	0.1609
Brugia malayi	AKH receptor	0.0056	0.1308	0.2216
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0056	0.1308	0.3533
Onchocerca volvulus		0.0032	0.0511	0.138
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0056	0.1308	0.2615
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Echinococcus granulosus	intermediate filament protein	0.0032	0.0511	0.0865
Brugia malayi	hypothetical protein	0.0056	0.1308	0.2216
Echinococcus multilocularis	allatostatin A receptor	0.0056	0.1308	0.2216
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0056	0.1308	0.2216
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0179	0.5438	1
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Brugia malayi	AMP-binding enzyme family protein	0.0028	0.0381	0.0646
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Brugia malayi	Cytochrome P450 family protein	0.0019	0.0072	0.0123
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0127	0.3701	0.7401
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0022	0.0187	0.0317
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0056	0.1308	0.2216
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0056	0.1308	0.2216
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0056	0.1308	0.2216
Brugia malayi	hypothetical protein	0.0056	0.1308	0.2216
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0028	0.0381	0.0563
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.006	0.1462	0.1462
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0056	0.1308	0.2216
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0082	0.2176	0.3687
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0022	0.0187	0.0187
Entamoeba histolytica	acyl-coA synthetase, putative	0.0028	0.0381	0.4361
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0381	0.0646
Schistosoma mansoni	lamin	0.0032	0.0511	0.1021
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0044	0.0926	0.0926
Toxoplasma gondii	hypothetical protein	0.0051	0.1145	0.2105
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.0187	0.0344
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0022	0.0187	0.0233
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Echinococcus granulosus	mitogen activated protein kinase	0.006	0.1462	0.2477
Trypanosoma cruzi	cytochrome P450, putative	0.0019	0.0072	0.0072
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0315	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.1569	0.1508
Echinococcus multilocularis	g protein coupled receptor	0.0056	0.1308	0.2216
Echinococcus multilocularis	neuropeptide receptor A26	0.0056	0.1308	0.2216
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1308	0.2216
Loa Loa (eye worm)	neuropeptide F receptor	0.0056	0.1308	0.2216
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0082	0.2176	0.4265
Onchocerca volvulus		0.0032	0.0511	0.138
Echinococcus multilocularis	mitogen activated protein kinase 3	0.006	0.1462	0.2477
Echinococcus granulosus	neutral alpha glucosidase AB	0.0043	0.0875	0.1483
Echinococcus granulosus	peptidase Clp S14 family	0.0053	0.1234	0.2091
Trichomonas vaginalis	conserved hypothetical protein	0.006	0.1468	1
Brugia malayi	putative neuropeptide receptor	0.0056	0.1308	0.2216
Schistosoma mansoni	alpha-glucosidase	0.0166	0.5001	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.005	0.1114	0.1114
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0056	0.1308	0.2615

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1200 nM	Inhibitory activity against human thromboxane synthetase	ChEMBL.	7199088

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL542548

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1035966