Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0039 | 0.2213 | 0.2999 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0039 | 0.2213 | 0.2009 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0031 | 0.1138 | 0.1543 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.3921 | 0.5859 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0031 | 0.1138 | 0.0906 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0031 | 0.1138 | 0.1701 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.2941 | 0.4395 |
Brugia malayi | Bromodomain containing protein | 0.004 | 0.236 | 0.1897 |
Plasmodium vivax | hypothetical protein, conserved | 0.0031 | 0.1138 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0063 | 0.5219 | 0.5094 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0038 | 0.2044 | 0.1835 |
Schistosoma mansoni | jumonji domain containing protein | 0.0079 | 0.7378 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.1138 | 0.1543 |
Giardia lamblia | PHD finger protein 15 | 0.0031 | 0.1138 | 0.5 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.01 | 1 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0063 | 0.5286 | 0.7899 |
Schistosoma mansoni | bromodomain containing protein | 0.0066 | 0.5698 | 0.7722 |
Brugia malayi | jmjC domain containing protein | 0.0039 | 0.2213 | 0.1741 |
Brugia malayi | Bromodomain containing protein | 0.0079 | 0.7263 | 0.7097 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0039 | 0.2213 | 0.2999 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.1138 | 0.1701 |
Echinococcus granulosus | peregrin | 0.0033 | 0.1455 | 0.1231 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0043 | 0.2664 | 0.2472 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0038 | 0.2044 | 0.1835 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0031 | 0.1138 | 0.5 |
Onchocerca volvulus | Alhambra homolog | 0.0031 | 0.1138 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0063 | 0.5219 | 0.5094 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.01 | 1 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0033 | 0.1455 | 0.0937 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0031 | 0.1138 | 0.0906 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0031 | 0.1138 | 0.5 |
Plasmodium falciparum | phd finger protein, putative | 0.0031 | 0.1138 | 0.5 |
Echinococcus multilocularis | peregrin | 0.0033 | 0.1455 | 0.1231 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.237 | 0.3541 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0037 | 0.1958 | 0.1747 |
Echinococcus granulosus | jumonji domain containing protein | 0.0043 | 0.2664 | 0.2472 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.2686 | 0.4014 |
Brugia malayi | PHD-finger family protein | 0.0031 | 0.1138 | 0.0601 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.6692 | 1 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0024 | 0.0255 | 0.0346 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0039 | 0.2213 | 0.3307 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 78 % | Antagonist activity at human P2X7 expressed in HEK293 cells assessed as inhibition of ATP-induced potassium release at 3 uM | ChEMBL. | 19191585 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.