Detailed information for compound 103634

Basic information

Technical information
  • TDR Targets ID: 103634
  • Name: 1-[4-(2-chlorophenyl)-6-methylquinolin-3-yl]- 3-(2,4-difluorophenyl)urea
  • MW: 423.842 | Formula: C23H16ClF2N3O
  • H donors: 2 H acceptors: 2 LogP: 5.57 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1F)F)Nc1cnc2c(c1c1ccccc1Cl)cc(cc2)C
  • InChi: 1S/C23H16ClF2N3O/c1-13-6-8-19-16(10-13)22(15-4-2-3-5-17(15)24)21(12-27-19)29-23(30)28-20-9-7-14(25)11-18(20)26/h2-12H,1H3,(H2,28,29,30)
  • InChiKey: KITCISNOGDGHMA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[4-(2-chlorophenyl)-6-methyl-3-quinolyl]-3-(2,4-difluorophenyl)urea
  • 1-[4-(2-chlorophenyl)-6-methyl-quinolin-3-yl]-3-(2,4-difluorophenyl)urea

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Acyl coenzyme A:cholesterol acyltransferase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis sterol O acyltransferase 1 Get druggable targets OG5_133487 All targets in OG5_133487
Schistosoma mansoni sterol O-acyltransferase 1 Get druggable targets OG5_133487 All targets in OG5_133487
Echinococcus granulosus sterol O acyltransferase 1 Get druggable targets OG5_133487 All targets in OG5_133487
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133487 All targets in OG5_133487
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133487 All targets in OG5_133487
Schistosoma japonicum ko:K00637 sterol O-acyltransferase [EC2.3.1.26], putative Get druggable targets OG5_133487 All targets in OG5_133487
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Neospora caninum sterol O-acyltransferase, putative Acyl coenzyme A:cholesterol acyltransferase 1   545 aa 510 aa 21.2 %
Dictyostelium discoideum diacylglycerol O-acyltransferase 1 Acyl coenzyme A:cholesterol acyltransferase 1   545 aa 547 aa 22.3 %
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha Acyl coenzyme A:cholesterol acyltransferase 1   545 aa 510 aa 24.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis orexin receptor type 2 0.0274 0.0694 0.0687
Toxoplasma gondii peptidase family M13 protein 0.0206 0.0488 0.4526
Echinococcus granulosus sortilin 0.0139 0.0286 0.0278
Echinococcus multilocularis integrin alpha ps 0.0133 0.0266 0.0259
Brugia malayi Guanylate kinase family protein 0.0052 0.0023 0.0022
Echinococcus granulosus integrin alpha ps 0.0133 0.0266 0.0259
Echinococcus granulosus Mastin 0.0075 0.0091 0.0083
Loa Loa (eye worm) hypothetical protein 0.0274 0.0694 0.0843
Brugia malayi Furin-like cysteine rich region family protein 0.0334 0.0874 0.1057
Trichomonas vaginalis cyclins, putative 0.0208 0.0493 0.0898
Echinococcus granulosus cyclin b3 0.013 0.0257 0.025
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0274 0.0694 0.0834
Schistosoma mansoni integrin beta subunit 0.0179 0.0405 0.0482
Brugia malayi celfurPC protein 0.2199 0.6514 0.7906
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.057 0.1589 0.3103
Loa Loa (eye worm) hypothetical protein 0.006 0.0046 0.0056
Onchocerca volvulus 0.0113 0.0208 0.0634
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0126 0.0246 0.2708
Echinococcus granulosus regulator of G protein signaling 3 0.006 0.0046 0.0038
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0274 0.0694 0.0834
Trichomonas vaginalis cyclin D, putative 0.013 0.0257 0.0425
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.057 0.1589 0.3103
Loa Loa (eye worm) proprotein convertase 2 0.0696 0.197 0.2392
Brugia malayi endoprotease bli-4 precursor 0.2769 0.8239 1
Loa Loa (eye worm) hypothetical protein 0.0274 0.0694 0.0843
Schistosoma mansoni axis inhibition protein axin 0.006 0.0046 0.0046
Echinococcus multilocularis g-protein coupled receptor 0.0274 0.0694 0.0687
Loa Loa (eye worm) hypothetical protein 0.0109 0.0194 0.0236
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0274 0.0694 0.0843
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0274 0.0694 0.0687
Onchocerca volvulus 0.0612 0.1716 0.8781
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0696 0.197 0.3869
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0274 0.0694 0.0687
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0274 0.0694 0.0687
Toxoplasma gondii cathepsin CPC2 0.0336 0.088 1
Mycobacterium leprae probable zinc metalloprotease 0.0206 0.0488 1
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0113 0.0208 0.2088
Echinococcus multilocularis neuropeptide Y receptor 0.0274 0.0694 0.0687
Schistosoma mansoni hypothetical protein 0.0054 0.0027 0.0024
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0264 0.0664 1
Echinococcus granulosus neuropeptide Y receptor 0.0274 0.0694 0.0687
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0126 0.0246 0.0402
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0126 0.0246 0.0402
Toxoplasma gondii subtilisin SUB9 0.0126 0.0246 0.116
Schistosoma mansoni integrin alpha-ps 0.0133 0.0266 0.0314
Echinococcus granulosus G2:mitotic specific cyclin B3 0.013 0.0257 0.025
Toxoplasma gondii subtilisin SUB8 0.0126 0.0246 0.116
Echinococcus multilocularis epidermal growth factor receptor 0.0334 0.0874 0.0867
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0174 0.039 0.0468
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0126 0.0246 0.0402
Loa Loa (eye worm) hypothetical protein 0.0075 0.0091 0.011
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.013 0.0257 0.025
Loa Loa (eye worm) hypothetical protein 0.0075 0.0091 0.011
Giardia lamblia Furin precursor putative serine protease 0.057 0.1589 0.5045
Echinococcus granulosus neuropeptide Y receptor 0.0274 0.0694 0.0687
Schistosoma mansoni cercarial elastase (S01 family) 0.0075 0.0091 0.01
Plasmodium falciparum subtilisin-like protease 2 0.0126 0.0246 0.0962
Mycobacterium ulcerans epoxide hydrolase EphA 0.017 0.038 0.5052
Schistosoma mansoni cercarial elastase (S01 family) 0.0075 0.0091 0.01
Loa Loa (eye worm) hypothetical protein 0.0274 0.0694 0.0843
Brugia malayi Integrin alpha pat-2 precursor 0.0296 0.076 0.0918
Schistosoma mansoni regulator of G protein signaling 0.0063 0.0054 0.0056
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0274 0.0694 0.0834
Trichomonas vaginalis conserved hypothetical protein 0.0109 0.0194 0.0298
Echinococcus multilocularis cyclins 0.013 0.0257 0.025
Brugia malayi RE15519p 0.0274 0.0694 0.0838
Onchocerca volvulus 0.0274 0.0694 0.3263
Trichomonas vaginalis conserved hypothetical protein 0.057 0.1589 0.3103
Trichomonas vaginalis conserved hypothetical protein 0.057 0.1589 0.3103
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0075 0.0091 0.01
Schistosoma mansoni apoptosis regulator bax 0.0055 0.003 0.0027
Loa Loa (eye worm) hypothetical protein 0.0224 0.0542 0.0658
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0113 0.0208 0.0325
Schistosoma mansoni cercarial elastase (S01 family) 0.0075 0.0091 0.01
Loa Loa (eye worm) hypothetical protein 0.0274 0.0694 0.0843
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0075 0.0091 0.01
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0113 0.0208 0.02
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0113 0.0208 0.0604
Brugia malayi Dopamine receptor protein 2 0.0274 0.0694 0.0838
Echinococcus granulosus neuropeptides capa receptor 0.0274 0.0694 0.0687
Echinococcus multilocularis membrane bound transcription factor site 1 0.0126 0.0246 0.0238
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0055 0.003 0.0022
Schistosoma mansoni hypothetical protein 0.0189 0.0436 0.052
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0126 0.0246 0.0238
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0336 0.088 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0126 0.0246 0.0402
Echinococcus granulosus rhodopsin orphan GPCR 0.0274 0.0694 0.0687
Brugia malayi G protein-coupled receptor F59B2.13 0.0274 0.0694 0.0838
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0126 0.0246 0.0238
Schistosoma mansoni serine-type protease inhibitor 0.264 0.785 0.9528
Echinococcus granulosus sterol O acyltransferase 1 0.0264 0.0663 0.0655
Brugia malayi Trypsin-like protease protein 5 0.0075 0.0091 0.0105
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0075 0.0091 0.01
Schistosoma mansoni cercarial elastase (S01 family) 0.0075 0.0091 0.01
Echinococcus granulosus Niemann Pick C1 protein 0.0109 0.0194 0.0186
Loa Loa (eye worm) hypothetical protein 0.0274 0.0694 0.0843
Onchocerca volvulus 0.0274 0.0694 0.3263
Loa Loa (eye worm) hypothetical protein 0.0512 0.1415 0.1717
Brugia malayi neuropeptide F receptor 0.0274 0.0694 0.0838
Entamoeba histolytica cyclin family protein 0.013 0.0257 0.4732
Trichomonas vaginalis cyclin B, putative 0.0208 0.0493 0.0898
Entamoeba histolytica cyclin, putative 0.0208 0.0493 1
Brugia malayi Angiotensin-converting enzyme family protein 0.123 0.3586 0.435
Schistosoma mansoni site-1 peptidase (S08 family) 0.0126 0.0246 0.0289
Schistosoma mansoni serine/threonine protein kinase 0.0142 0.0294 0.0348
Brugia malayi Protein kinase domain containing protein 0.0189 0.0436 0.0525
Onchocerca volvulus 0.0274 0.0694 0.3263
Onchocerca volvulus 0.0274 0.0694 0.3263
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0075 0.0091 0.0083
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0274 0.0694 0.0838
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0113 0.0208 0.02
Loa Loa (eye worm) hypothetical protein 0.0075 0.0091 0.011
Trypanosoma cruzi cyclin, putative 0.0208 0.0493 0.7024
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0104 0.0179 0.0208
Trypanosoma cruzi cyclin, putative 0.0208 0.0493 0.7024
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0126 0.0246 0.0293
Onchocerca volvulus 0.0274 0.0694 0.3263
Giardia lamblia Hypothetical protein 0.013 0.0257 0.0065
Loa Loa (eye worm) hypothetical protein 0.0152 0.0325 0.0395
Loa Loa (eye worm) peptidase family M1 containing protein 0.0312 0.0807 0.098
Onchocerca volvulus 0.0274 0.0694 0.3263
Schistosoma mansoni hypothetical protein 0.0055 0.003 0.0027
Brugia malayi peptidase family M13 containing protein 0.005 0.0017 0.0015
Mycobacterium ulcerans oxidoreductase 0.0104 0.0178 0.1532
Schistosoma mansoni tyrosine kinase 0.0334 0.0874 0.1053
Brugia malayi regulator of G-protein signaling rgs-7 0.006 0.0046 0.0051
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0274 0.0694 0.0834
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0274 0.0694 0.0838
Echinococcus multilocularis g protein coupled receptor 0.0274 0.0694 0.0687
Onchocerca volvulus 0.0274 0.0694 0.3263
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0075 0.0091 0.0083
Trypanosoma cruzi aminopeptidase, putative 0.0113 0.0208 0.2088
Onchocerca volvulus 0.0274 0.0694 0.3263
Loa Loa (eye worm) hypothetical protein 0.0156 0.0336 0.0408
Loa Loa (eye worm) hypothetical protein 0.0232 0.0568 0.0689
Loa Loa (eye worm) hypothetical protein 0.0274 0.0694 0.0843
Entamoeba histolytica cyclin family protein 0.013 0.0257 0.4732
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.123 0.3586 0.4353
Schistosoma mansoni biogenic amine receptor 0.0274 0.0694 0.0834
Echinococcus multilocularis cyclins 0.013 0.0257 0.025
Loa Loa (eye worm) hypothetical protein 0.0553 0.1538 0.1867
Brugia malayi hypothetical protein 0.0274 0.0694 0.0838
Loa Loa (eye worm) hypothetical protein 0.006 0.0046 0.0056
Echinococcus multilocularis cyclins 0.013 0.0257 0.025
Echinococcus multilocularis somatostatin receptor 0.0274 0.0694 0.0687
Echinococcus granulosus cyclins 0.013 0.0257 0.025
Echinococcus granulosus cyclins 0.013 0.0257 0.025
Echinococcus granulosus regulator of G protein signaling 7 0.006 0.0046 0.0038
Echinococcus multilocularis regulator of G protein signaling 3 0.006 0.0046 0.0038
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0113 0.0208 0.02
Loa Loa (eye worm) TK/ROR protein kinase 0.0189 0.0436 0.053
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0126 0.0246 0.2184
Loa Loa (eye worm) hypothetical protein 0.0274 0.0694 0.0843
Schistosoma mansoni site-1 peptidase (S08 family) 0.0126 0.0246 0.0289
Loa Loa (eye worm) hypothetical protein 0.0274 0.0694 0.0843
Echinococcus multilocularis neuropeptides capa receptor 0.0274 0.0694 0.0687
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0126 0.0246 0.0289
Brugia malayi G-protein coupled receptor 0.0274 0.0694 0.0838
Brugia malayi Peptidase family M1 containing protein 0.0385 0.103 0.1245
Toxoplasma gondii subtilisin SUB10 0.0126 0.0246 0.116
Trypanosoma cruzi UDP-galactopyranose mutase 0.0104 0.0178 0.1579
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0687 0.1941 0.2349
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.006 0.0046 0.0056
Echinococcus multilocularis glycoprotein Antigen 5 0.0075 0.0091 0.0083
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0274 0.0694 0.0687
Loa Loa (eye worm) hypothetical protein 0.0152 0.0325 0.0395
Onchocerca volvulus 0.0274 0.0694 0.3263
Loa Loa (eye worm) hypothetical protein 0.0274 0.0694 0.0843
Toxoplasma gondii histone lysine-specific demethylase 0.0104 0.0178 0.0219
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0104 0.0178 0.0219
Loa Loa (eye worm) hypothetical protein 0.0274 0.0694 0.0843
Echinococcus multilocularis g protein coupled receptor 0.0274 0.0694 0.0687
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.005 0.0017 0.001
Leishmania major subtilisin-like serine peptidase 0.0126 0.0246 0.1389
Brugia malayi hypothetical protein 0.0113 0.0208 0.0247
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0264 0.0664 0.0802
Schistosoma mansoni cyclins 0.013 0.0257 0.0303
Brugia malayi Cyclin, N-terminal domain containing protein 0.013 0.0257 0.0307
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0274 0.0694 0.0834
Loa Loa (eye worm) hypothetical protein 0.0064 0.0057 0.007
Trypanosoma cruzi UDP-galactopyranose mutase 0.0104 0.0178 0.1579
Echinococcus multilocularis allatostatin A receptor 0.0274 0.0694 0.0687
Echinococcus multilocularis rhodopsin orphan GPCR 0.0274 0.0694 0.0687
Echinococcus granulosus tachykinin peptides receptor 99D 0.0274 0.0694 0.0687
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0113 0.0208 0.02
Schistosoma mansoni regulator of G protein signaling 0.006 0.0046 0.0046
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0126 0.0246 0.2749
Onchocerca volvulus Neuropeptide F receptor homolog 0.0274 0.0694 0.3263
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0274 0.0694 0.0687
Schistosoma mansoni histamine h1 receptor 0.0274 0.0694 0.0834
Loa Loa (eye worm) hypothetical protein 0.0206 0.0488 0.0592
Loa Loa (eye worm) hypothetical protein 0.006 0.0046 0.0056
Echinococcus multilocularis sterol regulatory element binding protein 0.0109 0.0194 0.0186
Entamoeba histolytica aminopeptidase, putative 0.0113 0.0208 0.3622
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0126 0.0246 0.0402
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0274 0.0694 0.0687
Schistosoma mansoni opsin-like receptor 0.0274 0.0694 0.0834
Loa Loa (eye worm) hypothetical protein 0.0274 0.0694 0.0843
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0113 0.0208 0.02
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0683 0.1931 0.1924
Echinococcus granulosus neuropeptides capa receptor 0.0274 0.0694 0.0687
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0206 0.0488 1
Onchocerca volvulus 0.0274 0.0694 0.3263
Mycobacterium leprae Possible secreted protease 0.0126 0.0246 0.2184
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0274 0.0694 0.0834
Brugia malayi hypothetical protein 0.0274 0.0694 0.0838
Schistosoma mansoni amine GPCR 0.0274 0.0694 0.0834
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0126 0.0246 0.0402
Loa Loa (eye worm) hypothetical protein 0.0156 0.0336 0.0408
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0113 0.0208 0.02
Echinococcus granulosus hypothetical protein 0.0274 0.0694 0.0687
Trichomonas vaginalis cyclins, putative 0.0109 0.0195 0.0299
Echinococcus granulosus neuropeptide receptor A26 0.0737 0.2094 0.2088
Schistosoma mansoni hypothetical protein 0.0075 0.0091 0.01
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0274 0.0694 0.0843
Echinococcus granulosus epidermal growth factor receptor 0.0334 0.0874 0.0867
Echinococcus granulosus regulator of G protein signaling 7 0.006 0.0046 0.0038
Echinococcus multilocularis neuropeptide Y receptor 0.0274 0.0694 0.0687
Loa Loa (eye worm) hypothetical protein 0.0178 0.0403 0.0489
Onchocerca volvulus 0.0092 0.0143 0.0281
Schistosoma mansoni cercarial elastase (S01 family) 0.0075 0.0091 0.01
Loa Loa (eye worm) hypothetical protein 0.0274 0.0694 0.0843
Onchocerca volvulus 0.0189 0.0436 0.1868
Loa Loa (eye worm) hypothetical protein 0.0183 0.0419 0.0509
Echinococcus multilocularis protein patched 0.0109 0.0194 0.0186
Schistosoma mansoni integrin alpha-ps 0.0069 0.0074 0.008
Loa Loa (eye worm) integrin beta-2 0.0303 0.0782 0.0949
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0104 0.0179 0.0208
Echinococcus granulosus cyclin B 0.0208 0.0493 0.0485
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.005 0.0017 0.001
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0075 0.0091 0.0105
Schistosoma mansoni amine oxidase 0.0104 0.0178 0.0207
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0264 0.0664 1
Echinococcus granulosus axis inhibition protein axin 0.006 0.0046 0.0038
Loa Loa (eye worm) hypothetical protein 0.0208 0.0493 0.0598
Brugia malayi Cyclin, N-terminal domain containing protein 0.0208 0.0493 0.0593
Loa Loa (eye worm) hypothetical protein 0.0274 0.0694 0.0843
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0114 0.0209 0.0253
Echinococcus multilocularis rhodopsin orphan GPCR 0.0274 0.0694 0.0687
Mycobacterium ulcerans monoamine oxidase 0.0104 0.0178 0.1532
Echinococcus granulosus fmrfamide receptor 0.0274 0.0694 0.0687
Toxoplasma gondii kringle domain-containing protein 0.0189 0.0436 0.3812
Brugia malayi ORL1-like opioid receptor 0.0274 0.0694 0.0838
Echinococcus multilocularis dro:myosuppressin receptor 0.0274 0.0694 0.0687
Loa Loa (eye worm) hypothetical protein 0.0274 0.0694 0.0843
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0274 0.0694 0.0687
Echinococcus granulosus endothelin converting enzyme 1 0.0206 0.0488 0.048
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0274 0.0694 0.0687
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0126 0.0246 0.0402
Echinococcus granulosus somatostatin receptor 0.0274 0.0694 0.0687
Loa Loa (eye worm) hypothetical protein 0.0274 0.0694 0.0843
Loa Loa (eye worm) hypothetical protein 0.0274 0.0694 0.0843
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0114 0.0209 0.0253
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0126 0.0246 0.0402
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0696 0.197 0.3869
Onchocerca volvulus CoRest homolog 0.0183 0.0419 0.1775
Loa Loa (eye worm) PXA domain-containing protein 0.006 0.0046 0.0056
Onchocerca volvulus 0.0274 0.0694 0.3263
Schistosoma mansoni neuropeptide receptor 0.0274 0.0694 0.0834
Echinococcus multilocularis regulator of G protein signaling 7 0.006 0.0046 0.0038
Echinococcus multilocularis cyclins 0.013 0.0257 0.025
Echinococcus granulosus enteropeptidase 0.0075 0.0091 0.0083
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0274 0.0694 0.3263
Plasmodium falciparum sortilin 0.0139 0.0286 0.1535
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0174 0.039 0.0473
Schistosoma mansoni amine GPCR 0.0274 0.0694 0.0834
Brugia malayi regulator of G-protein signaling egl-10 0.006 0.0046 0.0051
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0274 0.0694 0.0687
Schistosoma mansoni neuropeptide receptor 0.0274 0.0694 0.0834
Echinococcus granulosus allatostatin A receptor 0.0274 0.0694 0.0687
Echinococcus granulosus cyclins 0.013 0.0257 0.025
Brugia malayi Peptidase family M13 containing protein 0.0206 0.0488 0.0587
Echinococcus multilocularis rhodopsin orphan GPCR 0.0274 0.0694 0.0687
Schistosoma mansoni biogenic amine receptor 0.0274 0.0694 0.0834
Loa Loa (eye worm) hypothetical protein 0.0152 0.0325 0.0395
Schistosoma mansoni serine/threonine protein kinase 0.0174 0.039 0.0464
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0113 0.0208 0.02
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0189 0.0436 0.3673
Echinococcus multilocularis fmrfamide receptor 0.0274 0.0694 0.0687
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0126 0.0246 0.0402
Schistosoma mansoni cercarial elastase (S01 family) 0.0075 0.0091 0.01
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0224 0.0542 0.0653
Brugia malayi Serotonin receptor 0.0274 0.0694 0.0838
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.006 0.0046 0.0038
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0126 0.0246 0.0293
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0126 0.0246 0.0402
Brugia malayi larval opioid receptor 0.0274 0.0694 0.0838
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.057 0.1589 0.3103
Toxoplasma gondii sortilin, putative 0.0139 0.0286 0.1721
Loa Loa (eye worm) G-protein coupled receptor 0.0274 0.0694 0.0843
Schistosoma mansoni cyclin B 0.0208 0.0493 0.0589
Echinococcus multilocularis endothelin converting enzyme 1 0.0206 0.0488 0.048
Loa Loa (eye worm) hypothetical protein 0.0074 0.0087 0.0106
Brugia malayi hypothetical protein 0.0274 0.0694 0.0838
Echinococcus multilocularis G-protein coupled receptor, putative 0.0274 0.0694 0.0687
Schistosoma mansoni opsin-like receptor 0.0274 0.0694 0.0834
Echinococcus multilocularis cyclin b3 0.013 0.0257 0.025
Echinococcus multilocularis neuropeptide receptor 0.0431 0.1168 0.1161
Brugia malayi follicle stimulating hormone receptor 0.0274 0.0694 0.0838
Schistosoma mansoni endothelin-converting enzyme-related 0.005 0.0017 0.001
Schistosoma mansoni amine GPCR 0.0274 0.0694 0.0834
Echinococcus granulosus sex peptide receptor 0.0274 0.0694 0.0687
Echinococcus granulosus peptide allatostatin:somatostatin 0.0274 0.0694 0.0687
Loa Loa (eye worm) hypothetical protein 0.0126 0.0246 0.0299
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0696 0.197 0.3869
Schistosoma mansoni integrin alpha 0.0296 0.076 0.0914
Schistosoma mansoni cercarial elastase (S01 family) 0.0075 0.0091 0.01
Loa Loa (eye worm) hypothetical protein 0.051 0.1408 0.1709
Brugia malayi hypothetical protein 0.0075 0.0091 0.0105
Echinococcus multilocularis Furin 1 0.0696 0.197 0.1964
Trichomonas vaginalis conserved hypothetical protein 0.057 0.1589 0.3103
Mycobacterium ulcerans zinc metalloprotease 0.0206 0.0488 0.6918
Loa Loa (eye worm) hypothetical protein 0.0274 0.0694 0.0843
Brugia malayi PXA domain containing protein 0.006 0.0046 0.0051
Echinococcus granulosus lysine specific histone demethylase 1A 0.0104 0.0178 0.0171
Brugia malayi hypothetical protein 0.0274 0.0694 0.0838
Loa Loa (eye worm) cyclin domain-containing protein 0.013 0.0257 0.0312
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0113 0.0208 0.02
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0274 0.0694 0.0834
Loa Loa (eye worm) hypothetical protein 0.0156 0.0336 0.0408
Echinococcus multilocularis 0.0104 0.0178 0.0171
Brugia malayi hypothetical protein 0.0274 0.0694 0.0838
Echinococcus granulosus tm gpcr rhodopsin 0.0274 0.0694 0.0687
Brugia malayi SWIRM domain containing protein 0.0553 0.1538 0.1863
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0104 0.0179 0.0208
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0264 0.0664 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0087 0.0106
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0274 0.0694 0.0834
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0206 0.0488 0.0587
Loa Loa (eye worm) hypothetical protein 0.0102 0.0173 0.0211
Echinococcus granulosus beta-adrenergic receptor kinase 0.0142 0.0294 0.0286
Schistosoma mansoni neuropeptide receptor 0.0274 0.0694 0.0834
Toxoplasma gondii subtilisin SUB2 0.0126 0.0246 0.116
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0142 0.0294 0.0357
Schistosoma mansoni biogenic amine receptor 0.0274 0.0694 0.0834
Loa Loa (eye worm) hypothetical protein 0.0687 0.1941 0.2356
Trichomonas vaginalis conserved hypothetical protein 0.057 0.1589 0.3103
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0274 0.0694 0.0834
Schistosoma mansoni hypothetical protein 0.0054 0.0027 0.0024
Echinococcus multilocularis rhodopsin orphan GPCR 0.0274 0.0694 0.0687
Brugia malayi hypoxia-induced factor 1 0.0147 0.0308 0.0369
Trichomonas vaginalis conserved hypothetical protein 0.057 0.1589 0.3103
Loa Loa (eye worm) hypothetical protein 0.0152 0.0325 0.0395
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.0246 0.0402
Loa Loa (eye worm) TYRA-2 protein 0.0274 0.0694 0.0843
Brugia malayi hypothetical protein 0.0274 0.0694 0.0838
Brugia malayi AKH receptor 0.0274 0.0694 0.0838
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0074 0.0087 0.0096
Loa Loa (eye worm) hypothetical protein 0.006 0.0046 0.0056
Loa Loa (eye worm) hypothetical protein 0.006 0.0046 0.0056
Echinococcus multilocularis expressed protein 0.076 0.2164 0.2158
Echinococcus multilocularis rhodopsin orphan GPCR 0.0274 0.0694 0.0687
Plasmodium falciparum cyclin 0.013 0.0257 0.1125
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0274 0.0694 0.0834
Loa Loa (eye worm) apoptosis regulator protein 0.0055 0.003 0.0036
Loa Loa (eye worm) trypsin family protein 0.0075 0.0091 0.011
Chlamydia trachomatis protoporphyrinogen oxidase 0.0104 0.0178 0.5
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0469 0.1284 0.155
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0696 0.197 0.3869
Loa Loa (eye worm) hypothetical protein 0.0272 0.0687 0.0834
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0113 0.0208 0.0604
Loa Loa (eye worm) hypothetical protein 0.0075 0.0091 0.011
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0126 0.0246 0.0402
Schistosoma mansoni amine GPCR 0.0274 0.0694 0.0834
Echinococcus multilocularis serotonin receptor 0.0274 0.0694 0.0687
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0274 0.0694 0.0834
Echinococcus multilocularis axis inhibition protein axin 0.006 0.0046 0.0038
Loa Loa (eye worm) neuropeptide F receptor 0.0274 0.0694 0.0843
Echinococcus granulosus alpha 1A adrenergic receptor 0.0274 0.0694 0.0687
Brugia malayi Cyclin, N-terminal domain containing protein 0.0208 0.0493 0.0593
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0274 0.0694 0.0838
Schistosoma mansoni neprilysin-2 (M13 family) 0.0104 0.0179 0.0208
Loa Loa (eye worm) hypothetical protein 0.0274 0.0694 0.0843
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0113 0.0208 0.0377
Loa Loa (eye worm) hypothetical protein 0.0274 0.0694 0.0843
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0126 0.0246 0.2184
Echinococcus granulosus membrane bound transcription factor site 1 0.0126 0.0246 0.0238
Schistosoma mansoni biogenic amine (5HT) receptor 0.0274 0.0694 0.0834
Trypanosoma brucei Aminopeptidase M1, putative 0.0113 0.0208 0.0377
Plasmodium vivax sortilin, putative 0.0139 0.0286 0.1535
Echinococcus granulosus serotonin receptor 0.0274 0.0694 0.0687
Brugia malayi Trypsin family protein 0.0075 0.0091 0.0105
Schistosoma mansoni neuropeptide F-like receptor 0.0274 0.0694 0.0834
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0113 0.0208 0.02
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1705 0.502 1
Loa Loa (eye worm) hypothetical protein 0.0147 0.0309 0.0375
Echinococcus granulosus Regulator of G protein signaling 20 0.006 0.0046 0.0038
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0104 0.0178 0.0207
Echinococcus multilocularis rhodopsin orphan GPCR 0.0274 0.0694 0.0687
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0274 0.0694 0.0834
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.005 0.0017 0.001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0126 0.0246 0.0402
Schistosoma mansoni sterol O-acyltransferase 1 0.0264 0.0663 0.0796
Trichomonas vaginalis cyclin A, putative 0.0208 0.0493 0.0898
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0274 0.0694 0.0834
Schistosoma mansoni hypothetical protein 0.0075 0.0091 0.01
Echinococcus granulosus orexin receptor type 2 0.0274 0.0694 0.0687
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.005 0.0017 0.001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0126 0.0246 0.0402
Trypanosoma brucei subtilisin peptidase 0.0126 0.0246 0.1181
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.017 0.038 0.6536
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0206 0.0488 0.0583
Toxoplasma gondii subtilisin SUB6 0.0126 0.0246 0.116
Brugia malayi Peptidase family M1 containing protein 0.0113 0.0208 0.0247
Echinococcus multilocularis 0.2199 0.6514 0.6511
Echinococcus granulosus integrin alpha ps 0.0064 0.0057 0.0049
Loa Loa (eye worm) hypothetical protein 0.0274 0.0694 0.0843
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0264 0.0664 0.0657
Brugia malayi sulfakinin receptor protein 0.0274 0.0694 0.0838
Loa Loa (eye worm) hypothetical protein 0.0156 0.0336 0.0408
Echinococcus multilocularis cyclin B 0.0208 0.0493 0.0485
Trichomonas vaginalis conserved hypothetical protein 0.057 0.1589 0.3103
Mycobacterium ulcerans aminopeptidase N PepN 0.0113 0.0208 0.2043
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0126 0.0246 0.1181
Loa Loa (eye worm) aminopeptidase N 0.0113 0.0208 0.0252
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0075 0.0091 0.0083
Onchocerca volvulus 0.0208 0.0493 0.2173
Echinococcus granulosus Protein patched homolog 1 0.0109 0.0194 0.0186
Trypanosoma cruzi cyclin 6, putative 0.0208 0.0493 0.7024
Echinococcus multilocularis neuropeptide receptor 0.0274 0.0694 0.0687
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.0246 0.0402
Loa Loa (eye worm) hypothetical protein 0.0687 0.1941 0.2356
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0696 0.197 0.2384
Trypanosoma cruzi hypothetical protein, conserved 0.0189 0.0436 0.6047
Trichomonas vaginalis cyclin B3, putative 0.013 0.0257 0.0425
Echinococcus granulosus biogenic amine 5HT receptor 0.0274 0.0694 0.0687
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0109 0.0194 0.0226
Echinococcus multilocularis cyclins 0.013 0.0257 0.025
Brugia malayi hypothetical protein 0.0274 0.0694 0.0838
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0336 0.088 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0274 0.0694 0.0843
Loa Loa (eye worm) hypothetical protein 0.0345 0.0909 0.1103
Schistosoma mansoni hypothetical protein 0.0054 0.0027 0.0024
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0208 0.0493 0.6465
Schistosoma mansoni hypothetical protein 0.0064 0.0057 0.006
Brugia malayi Dopamine receptor 0.0274 0.0694 0.0838
Brugia malayi G protein-coupled receptor 0.0274 0.0694 0.0838
Schistosoma mansoni neuropeptide F-like receptor 0.0274 0.0694 0.0834
Brugia malayi Regulator of G protein signaling domain containing protein 0.006 0.0046 0.0051
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0264 0.0664 0.0657
Loa Loa (eye worm) hypothetical protein 0.0078 0.01 0.0122
Loa Loa (eye worm) hypothetical protein 0.0208 0.0493 0.0598
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0126 0.0246 0.0402
Trichomonas vaginalis cyclins, putative 0.0208 0.0493 0.0898
Brugia malayi neuropeptide F receptor 0.0274 0.0694 0.0838
Toxoplasma gondii subtilisin SUB1 0.0126 0.0246 0.116
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0126 0.0246 0.2708
Echinococcus granulosus dro:myosuppressin receptor 0.0274 0.0694 0.0687
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0274 0.0694 0.0687
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0114 0.0209 0.0248
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0126 0.0246 0.0402
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0126 0.0246 0.0402
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0126 0.0246 0.2184
Brugia malayi Trypsin family protein 0.0075 0.0091 0.0105
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0126 0.0246 0.0402
Schistosoma mansoni regulator of G protein signaling 0.006 0.0046 0.0046
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0126 0.0246 0.2184
Loa Loa (eye worm) RGS-3 protein 0.006 0.0046 0.0056
Echinococcus granulosus integrin beta 2 0.0225 0.0544 0.0537
Loa Loa (eye worm) hypothetical protein 0.0274 0.0694 0.0843
Brugia malayi hypothetical protein 0.006 0.0046 0.0051
Loa Loa (eye worm) hypothetical protein 0.0274 0.0694 0.0843
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0274 0.0694 0.0687
Trypanosoma brucei Aminopeptidase M1, putative 0.0113 0.0208 0.0377
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0274 0.0694 0.0834
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0126 0.0246 0.0402
Echinococcus granulosus g-protein coupled receptor 0.0274 0.0694 0.0687
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0274 0.0694 0.0687
Brugia malayi Trypsin family protein 0.0687 0.1941 0.2352
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.006 0.0046 0.0046
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0126 0.0246 0.2184
Brugia malayi amine oxidase, flavin-containing family protein 0.0147 0.0309 0.037
Brugia malayi proprotein convertase 2 0.1761 0.5189 0.6297
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.006 0.0046 0.0038
Echinococcus granulosus cyclins 0.013 0.0257 0.025
Schistosoma mansoni growth hormone secretagogue receptor 0.0274 0.0694 0.0834
Loa Loa (eye worm) hypothetical protein 0.0274 0.0694 0.0843
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.1705 0.502 0.5016
Echinococcus multilocularis neuroendocrine convertase 2 0.1761 0.5189 0.5185
Loa Loa (eye worm) melatonin receptor type 1A 0.0274 0.0694 0.0843
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0264 0.0664 1
Loa Loa (eye worm) hypothetical protein 0.0274 0.0694 0.0843
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0274 0.0694 0.0843
Brugia malayi Subtilase family protein 0.0126 0.0246 0.0293
Brugia malayi putative neuropeptide receptor 0.0274 0.0694 0.0838
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0075 0.0091 0.0083
Echinococcus granulosus tissue type plasminogen activator 0.0189 0.0436 0.0429
Onchocerca volvulus 0.0102 0.0173 0.0448
Echinococcus granulosus G protein coupled receptor kinase 1 0.0082 0.0113 0.0105
Plasmodium falciparum cysteine repeat modular protein 1 0.0189 0.0436 0.3673
Schistosoma mansoni hypothetical protein 0.0054 0.0027 0.0024
Loa Loa (eye worm) hypothetical protein 0.2769 0.8239 1
Echinococcus multilocularis integrin beta 2 0.0225 0.0544 0.0537
Trichomonas vaginalis conserved hypothetical protein 0.057 0.1589 0.3103
Schistosoma mansoni amine oxidase 0.0104 0.0178 0.0207
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0188 0.0433 0.0517
Echinococcus granulosus cyclins 0.013 0.0257 0.025
Brugia malayi CHE-14 protein 0.0109 0.0194 0.0231
Echinococcus multilocularis neuropeptide FF receptor 2 0.0512 0.1415 0.1408
Brugia malayi Dopamine receptor protein 1 0.0274 0.0694 0.0838
Echinococcus multilocularis sex peptide receptor 0.0274 0.0694 0.0687
Schistosoma mansoni amine GPCR 0.0274 0.0694 0.0834
Trichomonas vaginalis cyclin B, putative 0.0208 0.0493 0.0898
Loa Loa (eye worm) G-protein coupled receptor 0.0274 0.0694 0.0843
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0696 0.197 0.3869
Brugia malayi hypothetical protein 0.0274 0.0694 0.0838
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0075 0.0091 0.01
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.0246 0.0402
Echinococcus granulosus g protein coupled receptor 0.0274 0.0694 0.0687
Onchocerca volvulus 0.0274 0.0694 0.3263
Trichomonas vaginalis cyclins, putative 0.013 0.0257 0.0425
Echinococcus multilocularis rhodopsin orphan GPCR 0.0274 0.0694 0.0687
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.005 0.0017 0.001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0274 0.0694 0.0834
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0696 0.197 0.3869
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0274 0.0694 0.0687
Echinococcus granulosus rhodopsin orphan GPCR 0.0274 0.0694 0.0687
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0124 0.024 0.039
Loa Loa (eye worm) hypothetical protein 0.051 0.1408 0.1709
Echinococcus granulosus g protein coupled receptor 0.0274 0.0694 0.0687
Echinococcus multilocularis beta adrenergic receptor kinase 0.0142 0.0294 0.0286
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1705 0.502 1
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.258 0.7668 0.9307
Echinococcus granulosus aminopeptidase N 0.0385 0.103 0.1022
Brugia malayi hypothetical protein 0.0104 0.0178 0.0211
Loa Loa (eye worm) TK/EGFR protein kinase 0.0334 0.0874 0.1061
Schistosoma mansoni hypothetical protein 0.0274 0.0694 0.0834
Schistosoma mansoni biogenic amine (5HT) receptor 0.0274 0.0694 0.0834
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0274 0.0694 0.0687
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0054 0.0027 0.0024
Schistosoma mansoni cercarial elastase (S01 family) 0.0075 0.0091 0.01
Loa Loa (eye worm) hypothetical protein 0.0274 0.0694 0.0843
Trichomonas vaginalis conserved hypothetical protein 0.057 0.1589 0.3103
Schistosoma mansoni hypothetical protein 0.0055 0.003 0.0027
Onchocerca volvulus 0.0687 0.1941 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0512 0.1415 0.1713
Loa Loa (eye worm) hypothetical protein 0.0274 0.0694 0.0843
Plasmodium vivax subtilisin-like protease 2, putative 0.0126 0.0246 0.0962
Loa Loa (eye worm) hypothetical protein 0.0274 0.0694 0.0843
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0274 0.0694 0.0838
Onchocerca volvulus 0.0274 0.0694 0.3263
Echinococcus multilocularis integrin alpha ps 0.0133 0.0266 0.0259
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0264 0.0664 0.0798
Schistosoma mansoni myosin xvIII 0.0274 0.0694 0.0834
Loa Loa (eye worm) hypothetical protein 0.0046 0.0004 0.0005
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0104 0.0178 0.1532
Echinococcus multilocularis neuropeptide receptor A26 0.0737 0.2094 0.2088
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0104 0.0179 0.0208
Trypanosoma cruzi subtilisin peptidase 0.0126 0.0246 0.2749
Loa Loa (eye worm) hypothetical protein 0.0274 0.0694 0.0843
Loa Loa (eye worm) hypothetical protein 0.0055 0.003 0.0036
Schistosoma mansoni serine-type protease inhibitor 0.264 0.785 0.9528
Toxoplasma gondii subtilisin SUB11 0.0126 0.0246 0.116
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.006 0.0046 0.0046
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0274 0.0694 0.0687
Brugia malayi hypothetical protein 0.0274 0.0694 0.0838
Echinococcus multilocularis serotonin receptor 0.0274 0.0694 0.0687
Schistosoma mansoni axis inhibition protein axin 0.006 0.0046 0.0046
Echinococcus granulosus rhodopsin orphan GPCR 0.0274 0.0694 0.0687
Trichomonas vaginalis conserved hypothetical protein 0.013 0.0257 0.0425
Loa Loa (eye worm) hypothetical protein 0.0274 0.0694 0.0843
Echinococcus multilocularis transmembrane protease serine 3 0.0075 0.0091 0.0083
Schistosoma mansoni serine/threonine protein kinase 0.0142 0.0294 0.0348
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0126 0.0246 0.0402
Loa Loa (eye worm) hypothetical protein 0.0274 0.0694 0.0843
Trichomonas vaginalis cyclins, putative 0.0208 0.0493 0.0898
Brugia malayi A-kinase anchor protein 10, precursor 0.006 0.0046 0.0051
Loa Loa (eye worm) hypothetical protein 0.0274 0.0694 0.0843
Trichomonas vaginalis cyclin B, putative 0.0208 0.0493 0.0898
Schistosoma mansoni opsin-like receptor 0.0274 0.0694 0.0834
Loa Loa (eye worm) hypothetical protein 0.0274 0.0694 0.0843
Brugia malayi PAS domain containing protein 0.0047 0.0008 0.0005
Loa Loa (eye worm) hypothetical protein 0.0274 0.0694 0.0843
Brugia malayi GnHR receptor homolog 0.0274 0.0694 0.0838
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0274 0.0694 0.0834
Schistosoma mansoni cyclin B3 0.013 0.0257 0.0303
Giardia lamblia High cysteine membrane protein Group 2 0.1008 0.2914 1
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0114 0.0209 0.0201
Loa Loa (eye worm) hypothetical protein 0.0238 0.0585 0.071
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0683 0.1931 0.1924
Echinococcus multilocularis Niemann Pick C1 protein 0.0109 0.0194 0.0186
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0126 0.0246 0.0402
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0126 0.0246 0.0402
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.3351 1 1
Echinococcus multilocularis regulator of G protein signaling 0.006 0.0046 0.0038
Trypanosoma cruzi CYC2-like cyclin, putative 0.0208 0.0493 0.7024
Onchocerca volvulus 0.0274 0.0694 0.3263
Echinococcus multilocularis G protein coupled receptor kinase 1 0.0082 0.0113 0.0105
Brugia malayi Kringle domain containing protein 0.0189 0.0436 0.0525
Schistosoma mansoni hypothetical protein 0.0054 0.0027 0.0024
Schistosoma mansoni Lysine-specific histone demethylase 1 0.051 0.1408 0.17
Echinococcus multilocularis cyclins 0.013 0.0257 0.025
Leishmania major cyclin 0.0208 0.0493 0.6465
Loa Loa (eye worm) subtilase 0.0126 0.0246 0.0299
Echinococcus granulosus rhodopsin orphan GPCR 0.0274 0.0694 0.0687
Toxoplasma gondii subtilisin SUB4 0.0126 0.0246 0.116
Echinococcus multilocularis tissue type plasminogen activator 0.0189 0.0436 0.0429
Echinococcus multilocularis enteropeptidase 0.0075 0.0091 0.0083
Echinococcus granulosus integrin alpha 3 0.0227 0.0551 0.0544
Plasmodium falciparum subtilisin-like protease 1 0.0126 0.0246 0.0962
Loa Loa (eye worm) hypothetical protein 0.0274 0.0694 0.0843
Brugia malayi G-protein coupled receptor 0.0274 0.0694 0.0838
Schistosoma mansoni hypothetical protein 0.0274 0.0694 0.0834
Trichomonas vaginalis conserved hypothetical protein 0.057 0.1589 0.3103
Trichomonas vaginalis conserved hypothetical protein 0.057 0.1589 0.3103
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.0246 0.0402
Loa Loa (eye worm) peptidase family M13 containing protein 0.0152 0.0325 0.0395
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0274 0.0694 0.0687
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0126 0.0246 0.2184
Brugia malayi neuroendocrine convertase 1 precursor 0.1761 0.5189 0.6297
Loa Loa (eye worm) hypothetical protein 0.0104 0.0178 0.0217
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0274 0.0694 0.0834
Onchocerca volvulus 0.0126 0.0246 0.084
Toxoplasma gondii subtilisin SUB7 0.0126 0.0246 0.116
Brugia malayi PXA domain containing protein 0.006 0.0046 0.0051
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0126 0.0246 0.2749
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0075 0.0091 0.01
Schistosoma mansoni regulator of G protein signaling 0.006 0.0046 0.0046
Echinococcus granulosus transmembrane protease serine 3 0.0075 0.0091 0.0083
Echinococcus multilocularis cyclin B3 1 0.013 0.0257 0.025
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0126 0.0246 0.0289
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0274 0.0694 0.0834
Loa Loa (eye worm) integrin alpha pat-2 0.0456 0.1245 0.1512
Brugia malayi hypothetical protein 0.0159 0.0346 0.0415
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.2769 0.8239 1
Loa Loa (eye worm) hypothetical protein 0.0156 0.0336 0.0408
Giardia lamblia G2/mitotic-specific cyclin B 0.0208 0.0493 0.0945
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0113 0.0208 0.0325
Loa Loa (eye worm) hypothetical protein 0.0274 0.0694 0.0843
Loa Loa (eye worm) hypothetical protein 0.0206 0.0488 0.0592
Echinococcus granulosus axis inhibition protein axin 0.006 0.0046 0.0038
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0104 0.0178 0.1532
Echinococcus granulosus rhodopsin orphan GPCR 0.0274 0.0694 0.0687
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0114 0.0209 0.0201
Schistosoma mansoni patched 1 0.0109 0.0194 0.0226
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0274 0.0694 0.0687
Schistosoma mansoni z-protein (S1r protein) 0.006 0.0046 0.0046
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0274 0.0694 0.0687
Echinococcus multilocularis regulator of G protein signaling 7 0.006 0.0046 0.0038
Schistosoma mansoni neuropeptide receptor 0.0431 0.1168 0.1409
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0046 0.0004 0.0005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0274 0.0694 0.0834
Loa Loa (eye worm) hypothetical protein 0.0274 0.0694 0.0843
Schistosoma mansoni hypothetical protein 0.0107 0.019 0.0221
Schistosoma mansoni cercarial elastase (S01 family) 0.0075 0.0091 0.01
Echinococcus multilocularis regulator of G protein signaling 3 0.006 0.0046 0.0038
Loa Loa (eye worm) hypothetical protein 0.0274 0.0694 0.0843
Echinococcus granulosus 7TM GPCR rhodopsin 0.0274 0.0694 0.0687
Schistosoma mansoni cercarial elastase (S01 family) 0.0075 0.0091 0.01
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0126 0.0246 0.2749
Echinococcus multilocularis fmrfamide receptor 0.0274 0.0694 0.0687
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0104 0.0178 0.1532
Echinococcus granulosus rhodopsin orphan GPCR 0.0274 0.0694 0.0687
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0274 0.0694 0.0834
Onchocerca volvulus 0.0274 0.0694 0.3263
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.0246 0.0402
Schistosoma mansoni regulator of G protein signaling 0.006 0.0046 0.0046
Onchocerca volvulus 0.0274 0.0694 0.3263
Loa Loa (eye worm) hypothetical protein 0.0274 0.0694 0.0843
Echinococcus granulosus neuropeptide receptor 0.0274 0.0694 0.0687
Loa Loa (eye worm) hypothetical protein 0.0159 0.0346 0.0419
Echinococcus granulosus glycoprotein Antigen 5 0.0075 0.0091 0.0083
Loa Loa (eye worm) hypothetical protein 0.0274 0.0694 0.0843
Echinococcus multilocularis aminopeptidase N 0.0385 0.103 0.1022
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0274 0.0694 0.0843
Loa Loa (eye worm) hypothetical protein 0.0274 0.0694 0.0843
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0274 0.0694 0.0687
Schistosoma mansoni hypothetical protein 0.0054 0.0027 0.0024
Echinococcus multilocularis integrin alpha 3 0.0227 0.0551 0.0544
Echinococcus granulosus G protein coupled receptor 139 0.0274 0.0694 0.0687
Schistosoma mansoni neuropeptide f receptor 76f 0.0274 0.0694 0.0834
Loa Loa (eye worm) hypothetical protein 0.0274 0.0694 0.0843
Brugia malayi Regulator of G protein signaling domain containing protein 0.006 0.0046 0.0051
Brugia malayi hypothetical protein 0.006 0.0046 0.0051
Echinococcus granulosus neuropeptide receptor 0.0431 0.1168 0.1161
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0687 0.1941 0.2349
Echinococcus multilocularis G protein coupled receptor 139 0.0431 0.1168 0.1161
Loa Loa (eye worm) hypothetical protein 0.1064 0.3084 0.3743
Schistosoma mansoni alpha-1 adrenergic receptor 0.0274 0.0694 0.0834
Echinococcus multilocularis lysine specific histone demethylase 1A 0.051 0.1408 0.1401
Echinococcus granulosus lysine specific histone demethylase 1A 0.051 0.1408 0.1401
Schistosoma mansoni hypothetical protein 0.0055 0.003 0.0027
Echinococcus multilocularis sterol O acyltransferase 1 0.0264 0.0663 0.0655
Echinococcus granulosus neuroendocrine convertase 2 0.1761 0.5189 0.5185
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0274 0.0694 0.0834
Brugia malayi Melatonin receptor type 1A 0.0274 0.0694 0.0838
Onchocerca volvulus 0.0385 0.103 0.5074
Echinococcus multilocularis sortilin 0.0139 0.0286 0.0278
Leishmania major hypothetical protein, conserved 0.0189 0.0436 0.5306
Loa Loa (eye worm) hypothetical protein 0.0274 0.0694 0.0843
Trichomonas vaginalis cyclin B, putative 0.0208 0.0493 0.0898
Loa Loa (eye worm) hypothetical protein 0.0274 0.0694 0.0843
Trichomonas vaginalis cyclin B, putative 0.013 0.0257 0.0425
Echinococcus granulosus rhodopsin orphan GPCR 0.0274 0.0694 0.0687
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0274 0.0694 0.0834
Loa Loa (eye worm) hypothetical protein 0.0274 0.0694 0.0843
Echinococcus granulosus tm gpcr rhodopsin 0.0274 0.0694 0.0687
Echinococcus multilocularis integrin alpha ps 0.0064 0.0057 0.0049
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0113 0.0208 0.02
Echinococcus multilocularis Regulator of G protein signaling 20 0.006 0.0046 0.0038
Mycobacterium ulcerans dehydrogenase 0.0104 0.0178 0.1532
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0126 0.0246 0.0402
Loa Loa (eye worm) hypothetical protein 0.0163 0.0359 0.0436
Loa Loa (eye worm) hypothetical protein 0.0075 0.0091 0.011
Entamoeba histolytica cyclin, putative 0.013 0.0257 0.4732
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0126 0.0246 0.0402
Echinococcus multilocularis neuropeptide s receptor 0.0737 0.2094 0.2088
Echinococcus multilocularis neuropeptides capa receptor 0.0274 0.0694 0.0687
Trypanosoma brucei mitotic cyclin 6 0.0208 0.0493 0.638
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.006 0.0046 0.0046
Trichomonas vaginalis hypothetical protein 0.057 0.1589 0.3103
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0055 0.003 0.0027
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0055 0.003 0.0022
Toxoplasma gondii subtilisin SUB5 0.0126 0.0246 0.116
Loa Loa (eye worm) hypothetical protein 0.0206 0.0488 0.0592
Echinococcus multilocularis protein dispatched 1 0.0109 0.0194 0.0186
Schistosoma mansoni adenoreceptor 0.0274 0.0694 0.0834
Echinococcus multilocularis protoporphyrinogen oxidase 0.0104 0.0178 0.0171
Plasmodium vivax subtilisin-like protease 1 0.0126 0.0246 0.0962
Echinococcus granulosus neuropeptide s receptor 0.0737 0.2094 0.2088
Echinococcus granulosus neuropeptide FF receptor 2 0.0512 0.1415 0.1408
Loa Loa (eye worm) hypothetical protein 0.0069 0.0074 0.009
Brugia malayi putative neuropeptide receptor NPR1 0.0274 0.0694 0.0838
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0109 0.0194 0.0236
Echinococcus multilocularis rhodopsin orphan GPCR 0.0274 0.0694 0.0687
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0126 0.0246 0.2708
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0055 0.003 0.0031
Giardia lamblia Cyclin A 0.013 0.0257 0.0065
Echinococcus granulosus g protein coupled receptor 0.0274 0.0694 0.0687
Plasmodium falciparum subtilisin-like protease 3 0.0126 0.0246 0.0962
Schistosoma mansoni cercarial elastase (S01 family) 0.0075 0.0091 0.01
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.1705 0.502 0.5016
Loa Loa (eye worm) hypothetical protein 0.0104 0.0178 0.0217
Loa Loa (eye worm) hypothetical protein 0.006 0.0046 0.0056
Loa Loa (eye worm) zinc metallopeptidase 4 0.005 0.0017 0.002
Brugia malayi hypothetical protein 0.0274 0.0694 0.0838
Plasmodium vivax subtilisin-like serine protease, putative 0.0126 0.0246 0.0962
Loa Loa (eye worm) hypothetical protein 0.0156 0.0336 0.0408
Schistosoma mansoni neprilysin 0.0054 0.0027 0.0024
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0124 0.024 0.039
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0113 0.0208 0.0243
Loa Loa (eye worm) hypothetical protein 0.0264 0.0664 0.0807
Schistosoma mansoni hypothetical protein 0.0274 0.0694 0.0834
Schistosoma mansoni hypothetical protein 0.0274 0.0694 0.0834
Brugia malayi Serotonin receptor 0.0274 0.0694 0.0838
Schistosoma mansoni furin-1 (S08 family) 0.119 0.3465 0.42
Loa Loa (eye worm) hypoxia-induced factor 1 0.0147 0.0308 0.0374
Onchocerca volvulus 0.0553 0.1538 0.7822
Onchocerca volvulus 0.0274 0.0694 0.3263
Echinococcus granulosus expressed protein 0.076 0.2164 0.2158
Echinococcus multilocularis Mastin 0.0075 0.0091 0.0083
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0124 0.024 0.039
Schistosoma mansoni hypothetical protein 0.057 0.1589 0.1921
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0264 0.0664 1
Echinococcus multilocularis cyclins 0.013 0.0257 0.025
Trichomonas vaginalis cyclins, putative 0.0208 0.0493 0.0898
Echinococcus multilocularis g protein coupled receptor 0.0274 0.0694 0.0687
Brugia malayi Integrin beta pat-3 precursor 0.0303 0.0782 0.0944
Loa Loa (eye worm) neuropeptide F receptor 0.0274 0.0694 0.0843
Echinococcus granulosus 7tm_1 domain containing protein 0.0274 0.0694 0.0687
Loa Loa (eye worm) hypothetical protein 0.0264 0.0663 0.0805
Trichomonas vaginalis conserved hypothetical protein 0.057 0.1589 0.3103
Echinococcus granulosus sterol regulatory element binding protein 0.0109 0.0194 0.0186
Trypanosoma cruzi Aminopeptidase M1, putative 0.0113 0.0208 0.2088
Brugia malayi Myb-like DNA-binding domain containing protein 0.0178 0.0403 0.0484
Echinococcus granulosus regulator of G protein signaling 3 0.006 0.0046 0.0038
Echinococcus multilocularis axis inhibition protein axin 0.006 0.0046 0.0038
Trichomonas vaginalis cyclin D, putative 0.013 0.0257 0.0425
Schistosoma mansoni sortilin 0.0099 0.0163 0.0189
Toxoplasma gondii subtilisin SUB12 0.0169 0.0375 0.2964
Echinococcus granulosus Furin 1 0.0696 0.197 0.1964
Brugia malayi Trypsin family protein 0.0075 0.0091 0.0105
Loa Loa (eye worm) hypothetical protein 0.0189 0.0436 0.053
Echinococcus granulosus furin 0.2769 0.8239 0.8237
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0126 0.0246 0.0402
Echinococcus granulosus cyclin B3 1 0.013 0.0257 0.025
Loa Loa (eye worm) endoprotease bli-4 0.2769 0.8239 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0274 0.0694 0.0687
Loa Loa (eye worm) peptidase family M13 containing protein 0.0152 0.0325 0.0395
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0074 0.0087 0.0079
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0274 0.0694 0.0838

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 16.8 nM Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes ChEMBL. 8027989
IC50 (binding) = 16.8 nM Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes ChEMBL. 8027989
Inhibition (binding) = 98.5 % Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase at 10 e-6 M in rat microsomes ChEMBL. 8027989
Inhibition (binding) = 98.5000000000002 % Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase at 10 e-6 M in rat microsomes ChEMBL. 8027989

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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