Detailed information for compound 1036420

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 671.091 | Formula: C33H35ClN2O11
  • H donors: 6 H acceptors: 7 LogP: 3.67 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 3
  • SMILES: COc1ccc(cc1)NC(=O)OC[C@@]1(O)C[C@H](OC2CC(N)C(C(O2)C)O)c2c(C1)c(O)c1c(c2O)C(=O)c2c(C1=O)cccc2.Cl
  • InChi: 1S/C33H34N2O11.ClH/c1-15-27(36)21(34)11-23(45-15)46-22-13-33(42,14-44-32(41)35-16-7-9-17(43-2)10-8-16)12-20-24(22)31(40)26-25(30(20)39)28(37)18-5-3-4-6-19(18)29(26)38;/h3-10,15,21-23,27,36,39-40,42H,11-14,34H2,1-2H3,(H,35,41);1H/t15?,21?,22-,23?,27?,33-;/m0./s1
  • InChiKey: OSHHLUDABDBHCU-PVSAOKTESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Protein kinase domain containing protein 0.0037 0.0043 0.0043
Trypanosoma cruzi cdc2-related kinase 1 0.0089 0.0364 0.1195
Echinococcus granulosus cyclin dependent kinase 5 0.0089 0.0364 0.0364
Echinococcus granulosus hypothetical protein 0.0121 0.0562 0.0562
Loa Loa (eye worm) TK/INSR protein kinase 0.0534 0.3113 0.3113
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0124 0.058 0.2005
Loa Loa (eye worm) hypothetical protein 0.009 0.037 0.037
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0037 0.0043 0.0043
Echinococcus multilocularis tubulin alpha chain 0.0037 0.0046 0.0046
Echinococcus multilocularis dual specificity 0.0182 0.0938 0.0938
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0081 0.0313 0.0313
Schistosoma mansoni alpha tubulin 0.0037 0.0046 0.0046
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0515 0.3 0.3
Brugia malayi Immunoglobulin I-set domain containing protein 0.0081 0.0313 0.0313
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0112 0.0505 0.0505
Loa Loa (eye worm) TK/ROR protein kinase 0.0034 0.0027 0.0027
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0468 0.2707 1
Echinococcus multilocularis cyclin dependent kinase 0.0089 0.0364 0.0364
Brugia malayi Fibronectin type III domain containing protein 0.0081 0.0313 0.0313
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0103 0.0103
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0229 0.1227 0.1227
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0089 0.0364 0.0364
Onchocerca volvulus 0.0037 0.0043 0.0447
Schistosoma mansoni tyrosine kinase 0.0534 0.3113 0.3113
Echinococcus multilocularis tubulin subunit TubB 0.0037 0.0046 0.0046
Echinococcus multilocularis neuroglian 0.0092 0.0384 0.0384
Brugia malayi hypothetical protein 0.0037 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.011 0.0498 0.0498
Echinococcus multilocularis Immunoglobulin 0.0081 0.0313 0.0313
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0075 0.0279 0.0279
Entamoeba histolytica cell division protein kinase 2, putative 0.0089 0.0364 0.3586
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0124 0.058 0.2005
Loa Loa (eye worm) hypothetical protein 0.0081 0.0313 0.0313
Onchocerca volvulus 0.0037 0.0043 0.0447
Schistosoma mansoni tyrosine kinase 0.0037 0.0043 0.0043
Echinococcus granulosus tubulin alpha 3 chain 0.0037 0.0046 0.0046
Schistosoma mansoni fructose-16-bisphosphatase-related 0.0468 0.2707 0.2707
Loa Loa (eye worm) hypothetical protein 0.0037 0.0046 0.0046
Schistosoma mansoni tyrosine kinase 0.0229 0.1227 0.1227
Echinococcus granulosus tyrosine kinase 0.0098 0.0419 0.0419
Loa Loa (eye worm) tubulin alpha chain 0.0037 0.0046 0.0046
Brugia malayi Tubulin alpha-2 chain 0.0037 0.0046 0.0046
Echinococcus granulosus tubulin alpha chain 0.0037 0.0046 0.0046
Echinococcus multilocularis epidermal growth factor receptor 0.1649 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0112 0.0505 0.0505
Echinococcus multilocularis tubulin alpha 3 chain 0.0037 0.0046 0.0046
Schistosoma mansoni tubulin subunit alpha 0.0037 0.0046 0.0046
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0043 0.0043
Brugia malayi Tubulin alpha-2 chain 0.0037 0.0046 0.0046
Plasmodium falciparum protein kinase 5 0.0089 0.0364 0.5962
Echinococcus multilocularis tubulin alpha 1C chain 0.0037 0.0046 0.0046
Echinococcus multilocularis Tubulin alpha 1 chain 0.0037 0.0046 0.0046
Trypanosoma brucei fructose-1,6-bisphosphatase 0.0468 0.2707 1
Onchocerca volvulus Tyrosine kinase homolog 0.0187 0.0972 1
Echinococcus granulosus tyrosine protein kinase Blk 0.0098 0.0419 0.0419
Schistosoma mansoni serine/threonine protein kinase 0.0089 0.0364 0.0364
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0174 0.0891 0.3176
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0043 0.0043
Onchocerca volvulus 0.0037 0.0043 0.0447
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0112 0.0505 0.0505
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0112 0.0505 0.0505
Schistosoma mansoni tyrosine kinase 0.0923 0.5517 0.5517
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0229 0.1227 0.1227
Brugia malayi SH2 domain containing protein 0.0037 0.0043 0.0043
Echinococcus granulosus peroxisome assembly protein 26 0.0037 0.0046 0.0046
Brugia malayi Protein kinase domain containing protein 0.0037 0.0043 0.0043
Echinococcus granulosus tubulin alpha chain 0.0037 0.0046 0.0046
Schistosoma mansoni tyrosine kinase 0.0037 0.0043 0.0043
Echinococcus multilocularis tyrosine protein kinase shark 0.0037 0.0043 0.0043
Echinococcus granulosus tubulin alpha 3 chain 0.0037 0.0046 0.0046
Echinococcus granulosus dual specificity 0.0182 0.0938 0.0938
Loa Loa (eye worm) hypothetical protein 0.0247 0.134 0.134
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.0468 0.2707 0.2707
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0124 0.058 0.2005
Entamoeba histolytica protein kinase domain containing protein 0.0182 0.0938 1
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.0174 0.0891 0.3176
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0174 0.0891 0.3176
Echinococcus granulosus Tubulin alpha 1 chain 0.0037 0.0046 0.0046
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0081 0.0313 0.0313
Toxoplasma gondii fructose-bisphospatase I 0.0174 0.0891 0.3176
Brugia malayi cell division control protein 2 homolog 0.0089 0.0364 0.0364
Echinococcus multilocularis insulin receptor 0.0534 0.3113 0.3113
Echinococcus multilocularis tyrosine protein kinase Srms 0.0098 0.0419 0.0419
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0182 0.0938 0.335
Echinococcus granulosus tyrosine protein kinase Src42A 0.0112 0.0505 0.0505
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0124 0.058 0.2005
Schistosoma mansoni tyrosine kinase 0.0946 0.5657 0.5657
Echinococcus multilocularis tubulin alpha 1C chain 0.0037 0.0046 0.0046
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.0468 0.2707 0.2707
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0051 0.0129 0.0129
Schistosoma mansoni microtubule-associated protein tau 0.0688 0.4066 0.4066
Echinococcus granulosus fructose 16 bisphosphatase 1 0.0468 0.2707 0.2707
Echinococcus granulosus tubulin alpha 1C chain 0.0037 0.0046 0.0046
Leishmania major protein kinase, putative 0.0124 0.058 0.2005
Echinococcus granulosus cyclin dependent kinase 1 0.0089 0.0364 0.0364
Echinococcus granulosus cyclin dependent kinase 0.0089 0.0364 0.0364
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0229 0.1227 0.1227
Echinococcus granulosus tubulin alpha chain 0.0037 0.0046 0.0046
Echinococcus multilocularis peroxisome assembly protein 26 0.0037 0.0046 0.0046
Schistosoma mansoni alpha tubulin 0.0037 0.0046 0.0046
Brugia malayi Protein kinase domain containing protein 0.0037 0.0043 0.0043
Schistosoma mansoni tyrosine kinase 0.0051 0.0129 0.0129
Loa Loa (eye worm) SRC-1 0.0112 0.0505 0.0505
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0034 0.0027 0.0027
Toxoplasma gondii fructose-bisphospatase II 0.0468 0.2707 1
Loa Loa (eye worm) TK protein kinase 0.0098 0.0419 0.0419
Brugia malayi Protein kinase domain containing protein 0.0124 0.058 0.058
Schistosoma mansoni tyrosine kinase 0.0453 0.2616 0.2616
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0041 0.0041
Entamoeba histolytica cell division protein kinase 2, putative 0.0089 0.0364 0.3586
Onchocerca volvulus 0.0037 0.0043 0.0447
Loa Loa (eye worm) hypothetical protein 0.0037 0.0043 0.0043
Schistosoma mansoni tubulin subunit alpha 0.0037 0.0046 0.0046
Echinococcus multilocularis tubulin alpha chain 0.0037 0.0046 0.0046
Schistosoma mansoni nephrin 0.0092 0.0384 0.0384
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0051 0.0129 0.0129
Brugia malayi tubulin alpha-2 chain 0.0037 0.0046 0.0046
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0043 0.0043
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0946 0.5657 0.5657
Echinococcus multilocularis microtubule associated protein 2 0.0688 0.4066 0.4066
Brugia malayi Protein kinase domain containing protein 0.0037 0.0043 0.0043
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0103 0.0103
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0043 0.0043
Echinococcus granulosus alpha tubulin 0.0037 0.0046 0.0046
Echinococcus granulosus tyrosine protein kinase Fyn 0.0112 0.0505 0.0505
Loa Loa (eye worm) TK protein kinase 0.024 0.1298 0.1298
Brugia malayi hypothetical protein 0.009 0.037 0.037
Plasmodium vivax protein kinase Crk2 0.0089 0.0364 0.5962
Schistosoma mansoni serine/threonine protein kinase 0.0124 0.058 0.058
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0182 0.0938 0.0938
Loa Loa (eye worm) hypothetical protein 0.0121 0.0562 0.0562
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0043 0.0043
Entamoeba histolytica protein kinase, putative 0.0084 0.0332 0.3228
Entamoeba histolytica tubulin alpha-1 chain 0.0037 0.0046 0.0028
Plasmodium vivax serine/threonine kinase-1, putative 0.0124 0.058 1
Schistosoma mansoni alpha tubulin 0.0037 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0515 0.3 0.3
Echinococcus multilocularis cyclin dependent kinase 5 0.0089 0.0364 0.0364
Echinococcus granulosus tubulin alpha chain 0.0037 0.0046 0.0046
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0182 0.0938 0.335
Onchocerca volvulus 0.0153 0.0761 0.7828
Brugia malayi Tubulin alpha chain 0.0037 0.0046 0.0046
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0098 0.0419 0.0419
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0043 0.0043
Entamoeba histolytica tubulin alpha chain, putative 0.0037 0.0046 0.0028
Brugia malayi Immunoglobulin I-set domain containing protein 0.0275 0.1512 0.1512
Echinococcus multilocularis tubulin alpha chain 0.0037 0.0046 0.0046
Echinococcus multilocularis tyrosine protein kinase Abl 0.0215 0.1146 0.1146
Echinococcus multilocularis tubulin alpha chain 0.0037 0.0046 0.0046
Plasmodium falciparum protein serine/threonine kinase-1 0.0124 0.058 1
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0089 0.0364 0.1195
Echinococcus granulosus tyrosine protein kinase Srms 0.0037 0.0043 0.0043
Entamoeba histolytica protein kinase, putative 0.0182 0.0938 1
Leishmania major 0.0468 0.2707 1
Trypanosoma brucei cdc2-related kinase 1 0.0089 0.0364 0.1195
Brugia malayi Protein kinase domain containing protein 0.0534 0.3113 0.3113
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0182 0.0938 0.335
Echinococcus granulosus tyrosine protein kinase HCK 0.0084 0.0332 0.0332
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0081 0.0313 0.0313
Schistosoma mansoni tyrosine kinase 0.0946 0.5657 0.5657
Giardia lamblia Kinase, CMGC CDK 0.0089 0.0364 0.5962
Loa Loa (eye worm) hypothetical protein 0.0179 0.092 0.092
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0124 0.058 0.2005
Schistosoma mansoni tyrosine kinase 0.0051 0.0129 0.0129
Brugia malayi alpha-tubulin 0.0037 0.0046 0.0046
Echinococcus granulosus neuroglian 0.0092 0.0384 0.0384
Echinococcus multilocularis c src tyrosine kinase 0.0051 0.0129 0.0129
Brugia malayi protein-tyrosine kinase 0.0098 0.0419 0.0419
Echinococcus granulosus tyrosine protein kinase shark 0.0037 0.0043 0.0043
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0534 0.3113 0.3113
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0089 0.0364 0.1195
Schistosoma mansoni tyrosine kinase 0.1649 1 1
Echinococcus granulosus dual specificity protein kinase clk2 0.0124 0.058 0.058
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0112 0.0505 0.0505
Echinococcus granulosus insulin receptor 0.0534 0.3113 0.3113
Loa Loa (eye worm) hypothetical protein 0.0081 0.0313 0.0313
Schistosoma mansoni tyrosine kinase 0.0923 0.5517 0.5517
Echinococcus granulosus c src tyrosine kinase 0.0051 0.0129 0.0129
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0103 0.0103
Echinococcus granulosus tyrosine protein kinase Src42A 0.0075 0.0279 0.0279
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0089 0.0364 0.0364
Brugia malayi SRC-1 0.0112 0.0505 0.0505
Brugia malayi Tyrosine-protein kinase abl-1 0.0215 0.1146 0.1146
Echinococcus granulosus tubulin subunit TubB 0.0037 0.0046 0.0046
Schistosoma mansoni serine/threonine protein kinase 0.0182 0.0938 0.0938
Loa Loa (eye worm) hypothetical protein 0.0099 0.0427 0.0427
Echinococcus granulosus epidermal growth factor receptor 0.0946 0.5657 0.5657
Echinococcus granulosus microtubule associated protein 2 0.0688 0.4066 0.4066
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0043 0.0043
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0124 0.058 0.058
Echinococcus granulosus Immunoglobulin 0.0081 0.0313 0.0313
Giardia lamblia Kinase, CMGC CLK 0.0124 0.058 1
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0112 0.0505 0.0505
Loa Loa (eye worm) TK/EGFR protein kinase 0.1649 1 1
Echinococcus granulosus roundabout 2 0.011 0.0498 0.0498
Schistosoma mansoni serine/threonine protein kinase 0.0089 0.0364 0.0364
Echinococcus multilocularis dual specificity protein kinase clk2 0.0124 0.058 0.058
Echinococcus granulosus defective proboscis extension response 0.0081 0.0313 0.0313
Echinococcus granulosus Tubulin alpha 1 chain 0.0037 0.0046 0.0046
Onchocerca volvulus 0.0037 0.0043 0.0447
Trichomonas vaginalis CMGC family protein kinase 0.0089 0.0364 0.5962
Loa Loa (eye worm) TK/ABL protein kinase 0.0468 0.2703 0.2703
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0124 0.058 0.2005
Echinococcus multilocularis Tubulin alpha 1 chain 0.0037 0.0046 0.0046
Trichomonas vaginalis CMGC family protein kinase 0.0089 0.0364 0.5962
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0033 0.0017 0.0017
Loa Loa (eye worm) tubulin alpha-2 chain 0.0037 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0086 0.0347 0.0347
Brugia malayi Tyrosine-protein kinase abl-1 0.0266 0.1459 0.1459
Echinococcus granulosus tyrosine kinase 0.0037 0.0043 0.0043
Echinococcus multilocularis hypothetical protein 0.0037 0.0046 0.0046
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0124 0.058 0.2005
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0043 0.0043
Echinococcus multilocularis tubulin alpha 3 chain 0.0037 0.0046 0.0046
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0112 0.0505 0.0505
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0089 0.0364 0.1195
Schistosoma mansoni tyrosine kinase 0.0053 0.014 0.014
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.1292 0.7797 0.7797
Trypanosoma brucei cdc2-related kinase 3 0.0089 0.0364 0.1195
Brugia malayi Protein kinase domain containing protein 0.0182 0.0938 0.0938
Brugia malayi hypothetical protein 0.0081 0.0313 0.0313
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0051 0.0129 0.0129
Echinococcus multilocularis 0.0585 0.3432 0.3432
Echinococcus multilocularis epidermal growth factor receptor 0.0946 0.5657 0.5657
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0103 0.0103
Brugia malayi SH2 domain containing protein 0.0037 0.0043 0.0043
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.011 0.0498 0.0498
Schistosoma mansoni vesicular amine transporter 0.0081 0.0313 0.0313
Echinococcus multilocularis cyclin dependent kinase 1 0.0089 0.0364 0.0364
Echinococcus granulosus tyrosine protein kinase Fyn 0.0112 0.0505 0.0505
Echinococcus granulosus tyrosine protein kinase Src64B 0.0112 0.0505 0.0505
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0112 0.0505 0.0505
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0037 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0187 0.0973 0.0973
Echinococcus multilocularis cyclin dependent kinase 1 0.0089 0.0364 0.0364
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0034 0.0027 0.0027
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0089 0.0364 0.0364
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0043 0.0043
Echinococcus multilocularis tubulin alpha chain 0.0037 0.0046 0.0046
Brugia malayi tubulin alpha chain - mouse 0.0037 0.0046 0.0046
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0515 0.3 0.3
Brugia malayi Immunoglobulin I-set domain containing protein 0.024 0.1298 0.1298
Echinococcus granulosus tyrosine protein kinase ABL1 0.0468 0.2703 0.2703
Schistosoma mansoni cell adhesion molecule 0.0099 0.0427 0.0427
Entamoeba histolytica hypothetical protein 0.0182 0.0938 1
Trypanosoma cruzi cdc2-related kinase 3 0.0089 0.0364 0.1195
Schistosoma mansoni tyrosine kinase 0.0112 0.0505 0.0505
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0515 0.3 0.3
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0112 0.0505 0.0505
Trypanosoma cruzi cdc2-related kinase 1 0.0089 0.0364 0.1195
Loa Loa (eye worm) hypothetical protein 0.009 0.037 0.037
Loa Loa (eye worm) tubulin alpha chain 0.0037 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0081 0.0313 0.0313
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0098 0.0419 0.0419
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.0174 0.0891 0.3176
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0534 0.3113 0.3113
Echinococcus multilocularis 0.0121 0.0562 0.0562
Trichomonas vaginalis CMGC family protein kinase 0.0124 0.058 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0103 0.0103
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0103 0.0103
Loa Loa (eye worm) TK protein kinase 0.0084 0.0332 0.0332
Trypanosoma cruzi cdc2-related kinase 3 0.0089 0.0364 0.1195
Echinococcus multilocularis Tubulin alpha 1 chain 0.0037 0.0046 0.0046
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0275 0.1512 0.1512
Echinococcus multilocularis tyrosine protein kinase Blk 0.0098 0.0419 0.0419
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0112 0.0505 0.0505
Echinococcus granulosus tyrosine protein kinase Fyn 0.0112 0.0505 0.0505
Leishmania major protein kinase, putative 0.0124 0.058 0.2005
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0103 0.0103
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0103 0.0103
Echinococcus multilocularis tyrosine kinase 0.0037 0.0043 0.0043
Echinococcus granulosus Tubulin alpha 1 chain 0.0037 0.0046 0.0046
Loa Loa (eye worm) alpha-tubulin 0.0037 0.0046 0.0046
Echinococcus granulosus tubulin alpha 1C chain 0.0037 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0081 0.0313 0.0313
Echinococcus granulosus twitchin 0.0095 0.0402 0.0402
Schistosoma mansoni tubulin subunit alpha 0.0037 0.0046 0.0046
Echinococcus granulosus fibroblast growth factor receptor 4 0.0229 0.1227 0.1227
Schistosoma mansoni tyrosine kinase 0.0534 0.3113 0.3113
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0112 0.0505 0.0505
Echinococcus granulosus tyrosine protein kinase Lyn 0.0114 0.0522 0.0522
Schistosoma mansoni serine/threonine protein kinase 0.0124 0.058 0.058
Loa Loa (eye worm) hypothetical protein 0.0247 0.134 0.134
Schistosoma mansoni tyrosine kinase 0.0112 0.0505 0.0505
Brugia malayi fructose-1,6-bisphosphatase 0.0468 0.2707 0.2707
Loa Loa (eye worm) hypothetical protein 0.0081 0.0313 0.0313
Entamoeba histolytica protein kinase, putative 0.0182 0.0938 1
Echinococcus granulosus tubulin alpha chain 0.0037 0.0046 0.0046
Brugia malayi Protein kinase domain containing protein 0.0089 0.0364 0.0364
Brugia malayi hypothetical protein 0.0247 0.134 0.134
Schistosoma mansoni eyes absent homolog 0.009 0.037 0.037
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0182 0.0938 0.335
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0099 0.0427 0.0427
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0468 0.2703 0.2703
Schistosoma mansoni tyrosine kinase 0.0923 0.5517 0.5517
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0081 0.0313 0.0313
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0089 0.0364 0.0364
Brugia malayi Protein kinase domain containing protein 0.0037 0.0043 0.0043
Echinococcus multilocularis roundabout 2 0.011 0.0498 0.0498
Loa Loa (eye worm) alpha-tubulin 0.0037 0.0046 0.0046
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0468 0.2707 1
Echinococcus multilocularis tyrosine protein kinase HCK 0.0084 0.0332 0.0332
Echinococcus multilocularis Immunoglobulin 0.0081 0.0313 0.0313
Onchocerca volvulus 0.0037 0.0043 0.0447
Trichomonas vaginalis CMGC family protein kinase 0.0089 0.0364 0.5962
Echinococcus granulosus epidermal growth factor receptor 0.1649 1 1
Loa Loa (eye worm) hypothetical protein 0.0179 0.092 0.092
Giardia lamblia Kinase, CMGC CDK 0.0089 0.0364 0.5962

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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