Detailed information for compound 103650

Basic information

Technical information
  • TDR Targets ID: 103650
  • Name: (E)-1-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl] -3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)prop- 2-en-1-one
  • MW: 375.464 | Formula: C23H25N3O2
  • H donors: 1 H acceptors: 3 LogP: 3.19 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC[C@@H]1CCCCN1C(=O)/C=C/c1c(nn2c1cccc2)c1ccccc1
  • InChi: 1S/C23H25N3O2/c27-17-14-19-10-4-6-15-25(19)22(28)13-12-20-21-11-5-7-16-26(21)24-23(20)18-8-2-1-3-9-18/h1-3,5,7-9,11-13,16,19,27H,4,6,10,14-15,17H2/b13-12+/t19-/m0/s1
  • InChiKey: OPLOPFHUHFGKMJ-HYSAVQALSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-1-[(2S)-2-(2-hydroxyethyl)-1-piperidyl]-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)prop-2-en-1-one
  • (E)-1-[(2S)-2-(2-hydroxyethyl)-1-piperidinyl]-3-(2-phenyl-3-pyrazolo[1,5-a]pyridinyl)-2-propen-1-one
  • (E)-1-[(2S)-2-(2-hydroxyethyl)piperidino]-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)prop-2-en-1-one
  • FK 453
  • (E)-1-[(2S)-2-(2-hydroxyethyl)-1-piperidinyl]-3-(2-phenyl-3-pyrazolo[1,5-a]pyridinyl)prop-2-en-1-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adenosine A2b receptor No references
Homo sapiens adenosine A2a receptor Starlite/ChEMBL No references
Cavia porcellus Adenosine A1 receptor Starlite/ChEMBL No references
Rattus norvegicus Adenosine A2 receptor Starlite/ChEMBL No references
Rattus norvegicus Adenosine A1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis allatostatin A receptor Adenosine A1 receptor   326 aa 303 aa 24.1 %
Schistosoma japonicum 5-hydroxytryptamine receptor 4, putative Adenosine A1 receptor   326 aa 286 aa 26.9 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Adenosine A2 receptor   410 aa 366 aa 25.4 %
Schistosoma mansoni dro/myosuppressin receptor Adenosine A1 receptor   326 aa 326 aa 22.1 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Adenosine A1 receptor   326 aa 315 aa 21.6 %
Schistosoma mansoni biogenic amine (5HT) receptor Adenosine A2 receptor   410 aa 399 aa 28.1 %
Onchocerca volvulus Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog Adenosine A1 receptor   326 aa 286 aa 22.7 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 304 aa 21.1 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Adenosine A1 receptor   326 aa 317 aa 24.6 %
Brugia malayi hypothetical protein Adenosine A1 receptor   326 aa 305 aa 21.0 %
Loa Loa (eye worm) hypothetical protein Adenosine A1 receptor   326 aa 300 aa 24.3 %
Echinococcus granulosus allatostatin A receptor Adenosine A1 receptor   326 aa 303 aa 24.1 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 323 aa 20.7 %
Schistosoma mansoni neuropeptide receptor Adenosine A1 receptor   326 aa 274 aa 22.6 %
Echinococcus multilocularis neuropeptide receptor Adenosine A1 receptor   326 aa 299 aa 22.4 %
Schistosoma mansoni opsin-like receptor Adenosine A1 receptor   326 aa 309 aa 21.0 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Adenosine A2 receptor   410 aa 340 aa 27.9 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Adenosine A1 receptor   326 aa 321 aa 22.7 %
Loa Loa (eye worm) neuropeptide F receptor Adenosine A1 receptor   326 aa 316 aa 19.9 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 306 aa 21.2 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Adenosine A2 receptor   410 aa 346 aa 28.3 %
Schistosoma japonicum Alpha-1A adrenergic receptor, putative Adenosine A1 receptor   326 aa 295 aa 28.1 %
Brugia malayi follicle stimulating hormone receptor adenosine A2a receptor 412 aa 336 aa 22.3 %
Onchocerca volvulus Adenosine A2 receptor   410 aa 356 aa 23.9 %
Echinococcus granulosus thyrotropin releasing hormone receptor Adenosine A1 receptor   326 aa 321 aa 23.1 %
Schistosoma mansoni neuropeptide receptor Adenosine A1 receptor   326 aa 311 aa 21.2 %
Onchocerca volvulus Adenosine A2 receptor   410 aa 337 aa 23.1 %
Echinococcus granulosus neuropeptide receptor Adenosine A1 receptor   326 aa 299 aa 22.4 %
Schistosoma mansoni peptide (allatostatin)-like receptor Adenosine A1 receptor   326 aa 327 aa 24.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.0052 0.0227 0.0431
Schistosoma mansoni carbonyl reductase 0.0028 0.0084 0.0204
Schistosoma mansoni hypothetical protein 0.0078 0.0388 0.0948
Onchocerca volvulus 0.0078 0.0388 0.159
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0113 0.0595 0.0549
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0098 0.0507 0.0963
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0032 0.0104 0.0055
Loa Loa (eye worm) hypothetical protein 0.0035 0.0123 0.0344
Giardia lamblia Heat shock protein HSP 90-alpha 0.0046 0.019 0.831
Echinococcus granulosus tm gpcr rhodopsin 0.0078 0.0388 0.0738
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0078 0.0388 0.0738
Echinococcus granulosus hypothetical protein 0.0032 0.0104 0.0198
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0053 0.0233 0.0745
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0419 0.2457 0.467
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0078 0.0388 0.0738
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0035 0.0123 0.0302
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.0104 0.0055
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.0104 0.0198
Schistosoma mansoni hypothetical protein 0.0034 0.0117 0.0286
Echinococcus granulosus g protein coupled receptor 0.0078 0.0388 0.0738
Onchocerca volvulus 0.0078 0.0388 0.159
Schistosoma mansoni nuclear receptor 0.0016 0.0012 0.0029
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0035 0.0123 0.0235
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0078 0.0388 0.0948
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0098 0.0507 0.0963
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0136 0.0088
Loa Loa (eye worm) hypothetical protein 0.0045 0.0187 0.0521
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.005 0.0213 0.1416
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0113 0.0595 0.0496
Echinococcus multilocularis lamin dm0 0.0027 0.0076 0.0144
Leishmania major heat shock protein 83-1 0.0046 0.019 0.1259
Echinococcus granulosus sex peptide receptor 0.0078 0.0388 0.0738
Trypanosoma cruzi heat shock protein 90, putative 0.0046 0.019 0.1259
Loa Loa (eye worm) neuropeptide F receptor 0.0078 0.0388 0.1083
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0113 0.0595 0.0496
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0113 0.0595 0.0496
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0078 0.0388 0.0738
Echinococcus granulosus neuropeptide receptor A26 0.0078 0.0388 0.0738
Trypanosoma cruzi aldo-keto reductase 0.0032 0.0104 0.0682
Schistosoma mansoni hypothetical protein 0.0016 0.0007 0.0017
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0007 0.0013
Echinococcus multilocularis G-protein coupled receptor, putative 0.0078 0.0388 0.0738
Leishmania major heat shock protein 83-1 0.0046 0.019 0.1259
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0035 0.0123 0.0392
Loa Loa (eye worm) hypothetical protein 0.0078 0.0388 0.1083
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0635 0.1773
Echinococcus granulosus glycine receptor subunit alpha 1 0.0472 0.2777 0.5279
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0098 0.0507 0.1415
Loa Loa (eye worm) endoplasmin 0.0046 0.019 0.0529
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0007 0.0016
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.1661 1 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0078 0.0388 0.159
Schistosoma mansoni histamine h1 receptor 0.0078 0.0388 0.0948
Echinococcus multilocularis carbonyl reductase 1 0.0028 0.0084 0.0159
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0033
Echinococcus multilocularis aldo keto reductase 0.0032 0.0104 0.0198
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.0104 0.0198
Leishmania major heat shock protein 83-1 0.0046 0.019 0.1259
Schistosoma mansoni intermediate filament proteins 0.0027 0.0076 0.0185
Loa Loa (eye worm) hypothetical protein 0.0035 0.0123 0.0344
Onchocerca volvulus 0.0078 0.0388 0.159
Loa Loa (eye worm) hypothetical protein 0.0045 0.0187 0.0521
Echinococcus multilocularis glycine receptor subunit beta 0.0472 0.2777 0.5279
Leishmania major protein phosphatase 2C-like protein 0.0023 0.0049 0.0314
Brugia malayi hypothetical protein 0.0078 0.0388 0.1248
Echinococcus granulosus single minded 2 0.014 0.0761 0.1446
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0472 0.2777 0.6787
Schistosoma mansoni neuropeptide F-like receptor 0.0078 0.0388 0.0948
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.1441 0.1398
Schistosoma mansoni neuropeptide f receptor 76f 0.0078 0.0388 0.0948
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.0104 0.0198
Trypanosoma brucei heat shock protein, putative 0.0046 0.019 0.1259
Trichomonas vaginalis aldo/keto reductase, putative 0.0032 0.0104 0.0055
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0045 0.0187 0.0596
Brugia malayi nuclear hormone receptor 0.0016 0.0012 0.0032
Echinococcus granulosus carbonyl reductase 1 0.0021 0.0037 0.007
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0113 0.0595 0.0496
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0113 0.0595 0.0549
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0113 0.0595 0.0496
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0012 0.0022
Echinococcus granulosus FTZ F1 alpha 0.0035 0.0123 0.0235
Brugia malayi hypothetical protein 0.0078 0.0388 0.1248
Loa Loa (eye worm) hypothetical protein 0.0037 0.0139 0.0389
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0635 0.1773
Mycobacterium ulcerans short chain dehydrogenase 0.0113 0.0595 0.0496
Leishmania major prostaglandin f synthase, putative 0.0032 0.0104 0.0682
Echinococcus multilocularis geminin 0.0502 0.2959 0.5625
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0218 0.017
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0066
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0113 0.0595 0.0496
Onchocerca volvulus 0.0027 0.0076 0.0269
Loa Loa (eye worm) hypothetical protein 0.0042 0.0165 0.0459
Onchocerca volvulus 0.0035 0.0123 0.0471
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0035 0.0123 0.0235
Echinococcus granulosus protein phosphatase 1b 0.0175 0.0974 0.1851
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0165 0.0915 0.1739
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0043 0.0173 0.0069
Brugia malayi GnHR receptor homolog 0.0078 0.0388 0.1248
Loa Loa (eye worm) nuclear hormone receptor 0.0016 0.0012 0.0033
Echinococcus multilocularis zinc finger protein 0.0019 0.0028 0.0053
Onchocerca volvulus 0.0097 0.0501 0.2066
Loa Loa (eye worm) hypothetical protein 0.0035 0.0123 0.0344
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0183 0.0447
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0098 0.0507 0.1632
Echinococcus multilocularis protein phosphatase 2C 0.0023 0.0049 0.0094
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.0358 0.0681
Echinococcus multilocularis carbonyl reductase 1 0.0028 0.0084 0.0159
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0388 0.0738
Echinococcus granulosus neuropeptides capa receptor 0.0078 0.0388 0.0738
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0051 0.022 0.0418
Loa Loa (eye worm) G-protein coupled receptor 0.0078 0.0388 0.1083
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0066
Loa Loa (eye worm) hypothetical protein 0.0078 0.0388 0.1083
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0113 0.0595 0.0496
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0043 0.0173 0.0125
Loa Loa (eye worm) hypothetical protein 0.0098 0.0507 0.1415
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0053 0.0233 0.0745
Schistosoma mansoni biogenic amine (5HT) receptor 0.0078 0.0388 0.0948
Trypanosoma brucei heat shock protein, putative 0.0046 0.019 0.1259
Onchocerca volvulus 0.0032 0.0104 0.039
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0218 0.0415
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0915 0.087
Loa Loa (eye worm) hypothetical protein 0.0078 0.0388 0.1083
Trypanosoma cruzi oxidoreductase-like protein, putative 0.012 0.0642 0.4307
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0016 0.0012 0.0033
Brugia malayi photoreceptor-specific nuclear receptor 0.0035 0.0123 0.0392
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0043 0.0173 0.1145
Trypanosoma cruzi short chain dehydrogenase, putative 0.0028 0.0084 0.0544
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0113 0.0595 0.0496
Toxoplasma gondii carbonyl reductase 1, putative 0.0028 0.0084 0.0034
Echinococcus multilocularis GPCR, family 2 0.0016 0.0007 0.0013
Echinococcus multilocularis neuropeptides capa receptor 0.0078 0.0388 0.0738
Onchocerca volvulus 0.0078 0.0388 0.159
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.0081 0.0403 0.1653
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0045 0.0187 0.0355
Onchocerca volvulus 0.0032 0.0104 0.039
Trypanosoma cruzi heat shock protein 85, putative 0.0046 0.019 0.1259
Loa Loa (eye worm) hypothetical protein 0.0098 0.0507 0.1415
Loa Loa (eye worm) hypothetical protein 0.0032 0.0104 0.029
Loa Loa (eye worm) hypothetical protein 0.0078 0.0388 0.1083
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.015 0.0989
Brugia malayi nuclear receptor RXR 0.0016 0.0012 0.0032
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0066
Chlamydia trachomatis oxoacy-ACP reductase 0.0113 0.0595 0.0377
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0388 0.0948
Giardia lamblia Heat shock protein HSP 90-alpha 0.0039 0.015 0.5937
Brugia malayi Nuclear hormone receptor-like 1 0.0035 0.0123 0.0392
Schistosoma mansoni neuropeptide receptor 0.0078 0.0388 0.0948
Schistosoma mansoni nAChR subunit 0.0098 0.0507 0.1239
Toxoplasma gondii heat shock protein 90, putative 0.0046 0.019 0.0141
Loa Loa (eye worm) hypothetical protein 0.0078 0.0388 0.1083
Loa Loa (eye worm) hypothetical protein 0.0045 0.0187 0.0521
Schistosoma mansoni acyl carrier protein 0.0052 0.0227 0.0555
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0078 0.0388 0.1248
Schistosoma mansoni carbonyl reductase 0.0021 0.0037 0.009
Echinococcus multilocularis allatostatin A receptor 0.0078 0.0388 0.0738
Loa Loa (eye worm) hypothetical protein 0.0053 0.0233 0.0649
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.005 0.0213 0.1416
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0915 0.087
Leishmania major short chain dehydrogenase, putative 0.0028 0.0084 0.0544
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.0388 0.0738
Mycobacterium ulcerans short chain dehydrogenase 0.012 0.0642 0.0544
Loa Loa (eye worm) hypothetical protein 0.0026 0.0073 0.0202
Leishmania major heat shock protein, putative 0.003 0.0097 0.0632
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0033
Echinococcus granulosus aryl hydrocarbon receptor 0.0408 0.2389 0.454
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0098 0.0507 0.1632
Brugia malayi nuclear receptor NHR-88 0.0035 0.0123 0.0392
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0125 0.0237
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0136 0.0259
Onchocerca volvulus 0.0053 0.0233 0.0933
Loa Loa (eye worm) G-protein coupled receptor 0.0078 0.0388 0.1083
Schistosoma mansoni opsin-like receptor 0.0078 0.0388 0.0948
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.0104 0.0055
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0013 0.0025
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0098 0.0507 0.0963
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0035 0.0123 0.0302
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0183 0.0348
Brugia malayi hypothetical protein 0.0078 0.0388 0.1248
Entamoeba histolytica aldose reductase, putative 0.0032 0.0104 0.1003
Echinococcus granulosus somatostatin receptor 0.0078 0.0388 0.0738
Mycobacterium ulcerans short chain dehydrogenase 0.0113 0.0595 0.0496
Brugia malayi excitatory GABA receptor EXP-1A 0.0098 0.0507 0.1632
Echinococcus multilocularis neuropeptides capa receptor 0.0078 0.0388 0.0738
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.0104 0.0055
Entamoeba histolytica hypothetical protein 0.0036 0.013 0.148
Onchocerca volvulus 0.0032 0.0104 0.039
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0013 0.0032
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0032 0.0104 0.0055
Schistosoma mansoni carbonyl reductase 0.0028 0.0084 0.0204
Loa Loa (eye worm) hypothetical protein 0.0078 0.0388 0.1083
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0076 0.0211
Loa Loa (eye worm) hypothetical protein 0.0035 0.0123 0.0344
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0125 0.0237
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.0104 0.0198
Onchocerca volvulus 0.012 0.0642 0.2663
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0046 0.0087
Echinococcus granulosus jun protein 0.0165 0.0915 0.1739
Schistosoma mansoni lamin 0.0027 0.0076 0.0185
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0028 0.0173
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0078 0.0388 0.0738
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.0104 0.0055
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0032 0.0104 0.033
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.003 0.0097 0.0358
Schistosoma mansoni heat shock protein 0.003 0.0097 0.0236
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0098 0.0507 0.0963
Brugia malayi Steroid receptor seven-up type 2 0.0035 0.0123 0.0392
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0472 0.2777 0.5279
Trypanosoma cruzi short chain dehydrogenase, putative 0.0028 0.0084 0.0544
Brugia malayi nuclear hormone receptor 0.0035 0.0123 0.0392
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.1441 0.1398
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0472 0.2777 0.7751
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0098 0.0507 0.1239
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0136 0.0088
Echinococcus multilocularis thyroid hormone receptor alpha 0.0035 0.0123 0.0235
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0035 0.0123 0.0344
Schistosoma mansoni zinc finger protein 0.0019 0.0028 0.0069
Mycobacterium ulcerans short chain dehydrogenase 0.0113 0.0595 0.0496
Brugia malayi hypothetical protein 0.0078 0.0388 0.1248
Echinococcus granulosus alpha 1A adrenergic receptor 0.0078 0.0388 0.0738
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.0104 0.0055
Plasmodium falciparum heat shock protein 90 0.0046 0.019 0.0141
Onchocerca volvulus 0.0078 0.0388 0.159
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.1661 1 1
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0113 0.0595 0.3992
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0016 0.0012 0.0022
Brugia malayi hypothetical protein 0.0078 0.0388 0.1248
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0078 0.0388 0.1083
Loa Loa (eye worm) hypothetical protein 0.0098 0.0507 0.1415
Brugia malayi hypothetical protein 0.0045 0.0187 0.0596
Treponema pallidum acyl carrier protein 0.0052 0.0227 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0078 0.0388 0.0738
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0018 0.0024 0.0066
Echinococcus granulosus PP-binding domain containing protein 0.0038 0.0143 0.0272
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.1661 1 1
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0472 0.2777 0.5279
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0218 0.017
Schistosoma mansoni protein phosphatase 2C 0.0023 0.0049 0.012
Brugia malayi hypothetical protein 0.0078 0.0388 0.1248
Echinococcus granulosus importin subunit beta 1 0.0057 0.0256 0.0487
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0035 0.0123 0.0392
Echinococcus granulosus neuropeptide s receptor 0.0078 0.0388 0.0738
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0098 0.0507 0.1632
Schistosoma mansoni nuclear receptor nhr-48 0.0016 0.0012 0.0029
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0078 0.0388 0.0948
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0419 0.2457 0.6857
Trichomonas vaginalis guanylate cyclase, putative 0.0049 0.021 0.0162
Loa Loa (eye worm) hypothetical protein 0.0053 0.0233 0.0649
Schistosoma mansoni endoplasmin 0.0046 0.019 0.0464
Onchocerca volvulus 0.0078 0.0388 0.159
Echinococcus granulosus carbonyl reductase 1 0.0028 0.0084 0.0159
Onchocerca volvulus 0.0098 0.0507 0.2092
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0218 0.1452
Mycobacterium tuberculosis Possible oxidoreductase 0.0113 0.0595 0.0496
Trypanosoma brucei Heat shock protein 83, putative 0.0046 0.019 0.1259
Onchocerca volvulus Neuropeptide F receptor homolog 0.0078 0.0388 0.159
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0035 0.0123 0.0235
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0098 0.0507 0.1632
Plasmodium vivax endoplasmin, putative 0.0046 0.019 0.0141
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0035 0.0123 0.0302
Mycobacterium ulcerans short chain dehydrogenase 0.0113 0.0595 0.0496
Schistosoma mansoni hypothetical protein 0.0502 0.2959 0.7232
Loa Loa (eye worm) hypothetical protein 0.0078 0.0388 0.1083
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0078 0.0388 0.0948
Brugia malayi Importin beta-1 subunit 0.0057 0.0256 0.0821
Trichomonas vaginalis ran, putative 0.0042 0.0165 0.0117
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0136 0.0033
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0136 0.5159
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0078 0.0388 0.0948
Echinococcus granulosus lamin dm0 0.0027 0.0076 0.0144
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0098 0.0507 0.0963
Brugia malayi PHD-finger family protein 0.0024 0.006 0.0186
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0183 0.0348
Schistosoma mansoni nAChR subunit 0.0098 0.0507 0.1239
Leishmania major GTP-binding protein, putative 0.0042 0.0165 0.1095
Echinococcus multilocularis endoplasmin 0.0043 0.0173 0.0328
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0098 0.0507 0.1239
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0218 0.1452
Echinococcus granulosus g protein coupled receptor 0.0078 0.0388 0.0738
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0035 0.0123 0.0235
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0098 0.0507 0.0963
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0035 0.0123 0.0302
Echinococcus granulosus Squalene phytoene synthase 0.0081 0.0403 0.0766
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0049 0.021 0.0162
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.012 0.0642 0.0596
Loa Loa (eye worm) hypothetical protein 0.0078 0.0388 0.1083
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0074 0.0024
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0012 0.0029
Schistosoma mansoni aldo-keto reductase 0.0032 0.0104 0.0254
Schistosoma mansoni carbonyl reductase 0.0028 0.0084 0.0204
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0035 0.0123 0.0392
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0013 0.0032
Schistosoma mansoni ran 0.0042 0.0165 0.0404
Leishmania major acyl carrier protein, putative 0.0052 0.0227 0.1511
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.0104 0.0198
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0098 0.0507 0.1632
Echinococcus multilocularis nAChR subunit 0.0053 0.0233 0.0442
Schistosoma mansoni aldo-keto reductase 0.0032 0.0104 0.0254
Loa Loa (eye worm) hypothetical protein 0.0098 0.0507 0.1415
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0472 0.2777 0.5279
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0039 0.015 0.0284
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0098 0.0507 0.1632
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.0104 0.0055
Schistosoma mansoni hypothetical protein 0.0502 0.2959 0.7232
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0046 0.0087
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0136 0.0901
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0035 0.0123 0.0235
Leishmania major heat shock protein 83-1 0.0046 0.019 0.1259
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0252 0.1441 0.4651
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0007 0.0019
Echinococcus granulosus biogenic amine 5HT receptor 0.0196 0.1105 0.21
Schistosoma mansoni growth hormone secretagogue receptor 0.0078 0.0388 0.0948
Loa Loa (eye worm) oxidoreductase 0.0032 0.0104 0.029
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0113 0.0595 0.3992
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0212 0.0591
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0113 0.0595 0.0496
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0113 0.0595 0.055
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0033
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0042 0.0165 0.0461
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0012 0.0022
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0012 0.0022
Trichomonas vaginalis hypothetical protein 0.1661 1 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0388 0.1083
Echinococcus multilocularis carbonyl reductase 1 0.0028 0.0084 0.0159
Loa Loa (eye worm) oxidoreductase 0.0032 0.0104 0.029
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0035 0.0123 0.0392
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0098 0.0507 0.1632
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0032 0.0104 0.033
Echinococcus granulosus neuropeptide receptor 0.0078 0.0388 0.0738
Schistosoma mansoni protein phosphatase 2C 0.0175 0.0974 0.238
Loa Loa (eye worm) hypothetical protein 0.0078 0.0388 0.1083
Loa Loa (eye worm) DR-78 0.0016 0.0012 0.0033
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0078 0.0388 0.0738
Plasmodium vivax heat shock protein, putative 0.0173 0.0964 0.0919
Echinococcus granulosus aldo keto reductase 0.0032 0.0104 0.0198
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0365 0.2129 0.6874
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0035 0.0123 0.0344
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.0138
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0024 0.007
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0266 0.0505
Toxoplasma gondii heat shock protein 75, putative 0.003 0.0097 0.0047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0035 0.0123 0.0344
Loa Loa (eye worm) hypothetical protein 0.0196 0.1105 0.3083
Mycobacterium ulcerans oxidoreductase 0.0113 0.0595 0.0496
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0388 0.0738
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0969 0.0924
Brugia malayi G-protein coupled receptor 0.0078 0.0388 0.1248
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0388 0.0738
Loa Loa (eye worm) hypothetical protein 0.0045 0.0187 0.0521
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0098 0.0507 0.1632
Echinococcus granulosus tm gpcr rhodopsin 0.0078 0.0388 0.0738
Echinococcus granulosus G protein coupled receptor 139 0.0078 0.0388 0.0738
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.0104 0.0198
Brugia malayi nuclear hormone receptor family member odr-7 0.0016 0.0012 0.0032
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0033
Schistosoma mansoni endoplasmin 0.0046 0.019 0.0464
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0035 0.0123 0.0235
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0969 0.0924
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0388 0.0948
Schistosoma mansoni zinc finger protein 0.0016 0.0012 0.0029
Schistosoma mansoni hypothetical protein 0.0015 0.0003 0.0007
Loa Loa (eye worm) hypothetical protein 0.0078 0.0388 0.1083
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0018 0.0024 0.0058
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0033
Mycobacterium leprae MEROMYCOLATE EXTENSION ACYL CARRIER PROTEIN ACPM 0.0038 0.0143 0.0095
Schistosoma mansoni hypothetical protein 0.0134 0.0727 0.1777
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.005 0.0213 0.1416
Echinococcus granulosus allatostatin A receptor 0.0078 0.0388 0.0738
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.0104 0.0198
Schistosoma mansoni steroid hormone receptor ad4bp 0.0035 0.0123 0.0302
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0098 0.0507 0.0963
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0252 0.1441 0.4021
Schistosoma mansoni pol-related 0.0032 0.0104 0.0254
Schistosoma mansoni biogenic amine (5HT) receptor 0.0196 0.1105 0.27
Schistosoma mansoni hypothetical protein 0.0036 0.013 0.0318
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0256 0.1706
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0035 0.0123 0.0235
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.005 0.0213 0.1416
Echinococcus granulosus peptide allatostatin:somatostatin 0.0078 0.0388 0.0738
Echinococcus multilocularis protein phosphatase 1b 0.0175 0.0974 0.1851
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0165 0.1095
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0078 0.0388 0.0738
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.0104 0.0055
Brugia malayi putative neuropeptide receptor NPR1 0.0078 0.0388 0.1248
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.1661 1 1
Echinococcus granulosus intermediate filament protein 0.0027 0.0076 0.0144
Onchocerca volvulus 0.0078 0.0388 0.159
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.0104 0.0198
Echinococcus granulosus serotonin receptor 0.0078 0.0388 0.0738
Schistosoma mansoni ran 0.0042 0.0165 0.0404
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0033
Echinococcus granulosus endoplasmin 0.0043 0.0173 0.0328
Schistosoma mansoni aryl hydrocarbon receptor 0.0548 0.3237 0.7911
Echinococcus multilocularis g protein coupled receptor 0.0078 0.0388 0.0738
Schistosoma mansoni heat shock protein 0.0046 0.019 0.0464
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0078 0.0388 0.1083
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0049 0.021 0.0162
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0045 0.0187 0.0355
Trypanosoma brucei protein phosphatase 2C, putative 0.0023 0.0049 0.0314
Treponema pallidum heat shock protein 90 0.0043 0.0173 0.3999
Echinococcus multilocularis carbonyl reductase 1 0.0028 0.0084 0.0159
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0042 0.0165 0.0117
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0049 0.021 0.0162
Echinococcus multilocularis heat shock protein 90 0.0046 0.019 0.0361
Brugia malayi Bromodomain containing protein 0.0037 0.0139 0.0442
Mycobacterium leprae Possible regulatory protein 0.0049 0.021 0.0162
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0098 0.0507 0.0963
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0042 0.0165 0.1095
Loa Loa (eye worm) hypothetical protein 0.0475 0.2798 0.7808
Loa Loa (eye worm) hypothetical protein 0.0078 0.0388 0.1083
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0136 0.0901
Loa Loa (eye worm) hypothetical protein 0.0078 0.0388 0.1083
Brugia malayi hypothetical protein 0.0078 0.0388 0.1248
Schistosoma mansoni protein phosphatase 2C 0.0153 0.0839 0.2051
Loa Loa (eye worm) hypothetical protein 0.0045 0.0187 0.0521
Mycobacterium ulcerans short chain dehydrogenase 0.0113 0.0595 0.0496
Schistosoma mansoni hypothetical protein 0.0081 0.0403 0.0985
Loa Loa (eye worm) hypothetical protein 0.0098 0.0507 0.1415
Loa Loa (eye worm) hypothetical protein 0.0161 0.0888 0.2477
Loa Loa (eye worm) hypothetical protein 0.0045 0.0187 0.0521
Echinococcus granulosus nuclear receptor nhr 48 0.0016 0.0012 0.0022
Loa Loa (eye worm) oxidoreductase 0.0113 0.0595 0.1662
Echinococcus multilocularis FTZ F1 alpha 0.0035 0.0123 0.0235
Schistosoma mansoni nAChR subunit 0.0098 0.0507 0.1239
Loa Loa (eye worm) hypothetical protein 0.0098 0.0507 0.1415
Loa Loa (eye worm) hypothetical protein 0.0098 0.0507 0.1415
Echinococcus granulosus 7TM GPCR rhodopsin 0.0078 0.0388 0.0738
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0033
Schistosoma mansoni amine GPCR 0.0078 0.0388 0.0948
Echinococcus multilocularis jun protein 0.0165 0.0915 0.1739
Echinococcus granulosus acyl carrier protein mitochondrial 0.0052 0.0227 0.0431
Trichomonas vaginalis heat shock protein, putative 0.0039 0.015 0.0101
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.0388 0.0738
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0007 0.0013
Schistosoma mansoni ap endonuclease 0.0037 0.0136 0.0333
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0191 0.0142
Onchocerca volvulus 0.0078 0.0388 0.159
Trypanosoma cruzi heat shock protein 85, putative 0.0046 0.019 0.1259
Mycobacterium ulcerans acyl carrier protein 0.0052 0.0227 0.0124
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0136 0.0435
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.013 0.0318
Brugia malayi steroid hormone receptor 0.0035 0.0123 0.0392
Echinococcus granulosus tachykinin peptides receptor 99D 0.0078 0.0388 0.0738
Loa Loa (eye worm) hypothetical protein 0.0045 0.0187 0.0521
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0053 0.0233 0.0568
Schistosoma mansoni thyroid hormone receptor 0.0035 0.0123 0.0302
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0066
Echinococcus multilocularis snurportin 1 0.0605 0.3583 0.681
Toxoplasma gondii heat shock protein HSP90 0.0046 0.019 0.0141
Brugia malayi ecdysone receptor 0.0016 0.0012 0.0032
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.015 0.0989
Trypanosoma brucei protein phosphatase 2C, putative 0.0023 0.0049 0.0314
Brugia malayi Protein phosphatase 2C containing protein 0.0175 0.0974 0.3141
Brugia malayi Cation transporter family protein 0.0098 0.0507 0.1632
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0078 0.0388 0.0738
Leishmania major aldo-keto reductase-like protein 0.0032 0.0104 0.0682
Schistosoma mansoni hypothetical protein 0.0078 0.0388 0.0948
Schistosoma mansoni hypothetical protein 0.0016 0.0007 0.0017
Loa Loa (eye worm) hypothetical protein 0.0078 0.0388 0.1083
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0078 0.0388 0.0738
Onchocerca volvulus 0.0078 0.0388 0.159
Echinococcus granulosus aldehyde reductase 0.0022 0.0048 0.0092
Loa Loa (eye worm) hypothetical protein 0.0078 0.0388 0.1083
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.013 0.0247
Echinococcus multilocularis microtubule associated protein 2 0.0688 0.4092 0.7777
Leishmania major heat shock protein 83-1 0.0046 0.019 0.1259
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0078 0.0388 0.0948
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0472 0.2777 0.5279
Schistosoma mansoni opsin-like receptor 0.0078 0.0388 0.0948
Loa Loa (eye worm) hypothetical protein 0.0365 0.2129 0.594
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0033
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0136 0.0259
Leishmania major heat shock protein 83-1 0.0046 0.019 0.1259
Echinococcus granulosus heat shock protein 0.0046 0.019 0.0361
Brugia malayi RNA, U transporter 1 0.0161 0.089 0.2871
Trypanosoma cruzi importin beta-1 subunit, putative 0.0046 0.0191 0.1268
Mycobacterium ulcerans putative regulatory protein 0.014 0.0761 0.0664
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.0104 0.0198
Echinococcus multilocularis lamin 0.0027 0.0076 0.0144
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0046 0.0111
Trypanosoma brucei heat shock protein 90, putative 0.0046 0.019 0.1259
Loa Loa (eye worm) hypothetical protein 0.0427 0.2503 0.6985
Echinococcus multilocularis neuropeptide receptor A26 0.0078 0.0388 0.0738
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0042 0.0165 0.6863
Trichomonas vaginalis aldo/keto reductase, putative 0.0032 0.0104 0.0055
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0024 0.007
Echinococcus multilocularis aldo keto reductase 0.0032 0.0104 0.0198
Loa Loa (eye worm) nuclear receptor NHR-67 0.0016 0.0012 0.0033
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.0104 0.0055
Loa Loa (eye worm) hypothetical protein 0.0359 0.2091 0.5834
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0388 0.0948
Echinococcus granulosus GPCR family 2 0.0016 0.0007 0.0013
Echinococcus granulosus 7tm_1 domain containing protein 0.0078 0.0388 0.0738
Brugia malayi hypothetical protein 0.0045 0.0187 0.0596
Loa Loa (eye worm) hypothetical protein 0.0078 0.0388 0.1083
Onchocerca volvulus Bile acid receptor homolog 0.0035 0.0123 0.0471
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0035 0.0123 0.0392
Schistosoma mansoni nAChR subunit 0.0045 0.0187 0.0456
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0012 0.0029
Loa Loa (eye worm) hypothetical protein 0.0078 0.0388 0.1083
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.0104 0.0198
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.021 0.0162
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.0358 0.0681
Mycobacterium ulcerans proteasome PrcA 0.0817 0.4874 0.482
Trypanosoma cruzi heat shock protein, putative 0.003 0.0097 0.0632
Schistosoma mansoni myosin xvIII 0.0078 0.0388 0.0948
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0218 0.1452
Entamoeba histolytica 90 kDa heat shock protein, putative 0.003 0.0097 0.0865
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0218 0.0415
Loa Loa (eye worm) hypothetical protein 0.0098 0.0507 0.1415
Trichomonas vaginalis heat shock protein, putative 0.0033 0.0114 0.0065
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0032 0.0104 0.033
Brugia malayi conserved hypotetical protein 0.0016 0.0012 0.0032
Loa Loa (eye worm) hypothetical protein 0.0357 0.2081 0.5807
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0117 0.0371
Loa Loa (eye worm) hypothetical protein 0.0053 0.0233 0.0649
Echinococcus granulosus aldo keto reductase 0.0032 0.0104 0.0198
Echinococcus granulosus microtubule associated protein 2 0.0688 0.4092 0.7777
Onchocerca volvulus 0.0028 0.0084 0.0303
Trypanosoma brucei heat shock protein, putative 0.0046 0.019 0.1259
Loa Loa (eye worm) hypothetical protein 0.0045 0.0187 0.0521
Echinococcus multilocularis serotonin receptor 0.0196 0.1105 0.21
Echinococcus granulosus carbonyl reductase 1 0.0028 0.0084 0.0159
Brugia malayi AKH receptor 0.0078 0.0388 0.1248
Trypanosoma cruzi heat shock protein 85, putative 0.0046 0.019 0.1259
Schistosoma mansoni neurotransmitter gated ion channel 0.0053 0.0233 0.0568
Schistosoma mansoni neuropeptide receptor 0.0078 0.0388 0.0948
Onchocerca volvulus 0.0078 0.0388 0.159
Loa Loa (eye worm) hypothetical protein 0.0098 0.0507 0.1415
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0032 0.0104 0.0682
Entamoeba histolytica Ran family GTPase 0.0042 0.0165 0.2124
Brugia malayi neuropeptide F receptor 0.0078 0.0388 0.1248
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0013 0.0025
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0016 0.0012 0.0022
Echinococcus multilocularis G protein coupled receptor 139 0.0078 0.0388 0.0738
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0218 0.1452
Loa Loa (eye worm) hypothetical protein 0.0035 0.0123 0.0344
Plasmodium vivax acyl carrier protein, putative 0.0052 0.0227 0.0179
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0035 0.0123 0.0344
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0113 0.0595 0.0496
Brugia malayi RE15519p 0.0078 0.0388 0.1248
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0388 0.0948
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0388 0.0948
Echinococcus granulosus glycine receptor subunit beta 0.0472 0.2777 0.5279
Loa Loa (eye worm) heat shock protein 90 0.0046 0.019 0.0529
Echinococcus granulosus g protein coupled receptor 0.0078 0.0388 0.0738
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.0104 0.0198
Schistosoma mansoni hypothetical protein 0.0078 0.0388 0.0948
Loa Loa (eye worm) hypothetical protein 0.0078 0.0388 0.1083
Entamoeba histolytica hypothetical protein 0.0046 0.0191 0.2595
Echinococcus granulosus carbonyl reductase 1 0.0028 0.0084 0.0159
Brugia malayi PAS domain containing protein 0.0189 0.1059 0.3416
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0388 0.0738
Loa Loa (eye worm) LGC-31 protein 0.0098 0.0507 0.1415
Schistosoma mansoni hypothetical protein 0.0078 0.0388 0.0948
Loa Loa (eye worm) hypothetical protein 0.0078 0.0388 0.1083
Trichomonas vaginalis heat shock protein, putative 0.0043 0.0173 0.0124
Onchocerca volvulus Protein ultraspiracle homolog 0.0035 0.0123 0.0471
Onchocerca volvulus 0.0406 0.2379 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0016 0.0012 0.0022
Echinococcus multilocularis neuropeptide Y receptor 0.0078 0.0388 0.0738
Mycobacterium ulcerans short chain dehydrogenase 0.0113 0.0595 0.0496
Schistosoma mansoni protein phosphatase 2C 0.0153 0.0839 0.2051
Brugia malayi orphan nuclear receptor NR2E1 0.0016 0.0012 0.0032
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0113 0.0595 0.0496
Loa Loa (eye worm) GABA receptor subunit 0.0427 0.2503 0.6985
Schistosoma mansoni biogenic amine receptor 0.0078 0.0388 0.0948
Schistosoma mansoni acetylcholine receptor-related 0.0045 0.0187 0.0456
Trypanosoma brucei Acyl carrier protein, mitochondrial 0.0052 0.0227 0.1511
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0035 0.0123 0.0235
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0035 0.0123 0.0344
Trichomonas vaginalis heat shock protein, putative 0.0046 0.019 0.0141
Onchocerca volvulus 0.0078 0.0388 0.159
Schistosoma mansoni biogenic amine receptor 0.0078 0.0388 0.0948
Brugia malayi heat shock protein 90 0.0046 0.019 0.0607
Loa Loa (eye worm) hypothetical protein 0.0406 0.2379 0.6638
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0017 0.0047
Echinococcus granulosus neuropeptide Y receptor 0.0078 0.0388 0.0738
Trypanosoma brucei heat shock protein, putative 0.0046 0.019 0.1259
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0018 0.0024 0.0045
Echinococcus granulosus tm gpcr rhodopsin 0.0881 0.5261 1
Loa Loa (eye worm) acetylcholine receptor protein 0.0045 0.0187 0.0521
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0012 0.0032
Loa Loa (eye worm) hypothetical protein 0.0098 0.0507 0.1415
Schistosoma mansoni opsin-like receptor 0.0078 0.0388 0.0948
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.003 0.0097 0.0184
Echinococcus multilocularis neuropeptide Y receptor 0.0078 0.0388 0.0738
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0078 0.0388 0.1083
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0605 0.3583 1
Echinococcus multilocularis fmrfamide receptor 0.0078 0.0388 0.0738
Echinococcus granulosus neuropeptide receptor 0.0078 0.0388 0.0738
Onchocerca volvulus 0.0078 0.0388 0.159
Loa Loa (eye worm) hypothetical protein 0.0053 0.0233 0.0649
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0113 0.0595 0.1455
Echinococcus multilocularis orexin receptor type 2 0.0078 0.0388 0.0738
Echinococcus granulosus ecdysone induced protein 78C 0.0035 0.0123 0.0235
Mycobacterium tuberculosis Possible oxidoreductase 0.0113 0.0595 0.0496
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0136 0.0088
Leishmania major importin beta-1 subunit, putative 0.0046 0.0191 0.1268
Brugia malayi Endoplasmin precursor 0.0046 0.019 0.0607
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0218 0.0533
Loa Loa (eye worm) hypothetical protein 0.0078 0.0388 0.1083
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0113 0.0595 0.0549
Entamoeba histolytica hypothetical protein 0.0036 0.013 0.148
Loa Loa (eye worm) hypothetical protein 0.0098 0.0507 0.1415
Brugia malayi hypothetical protein 0.0045 0.0187 0.0596
Loa Loa (eye worm) hypothetical protein 0.0078 0.0388 0.1083
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0113 0.0595 0.1662
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0035 0.0123 0.0235
Schistosoma mansoni nAChR subunit 0.0045 0.0187 0.0456
Loa Loa (eye worm) hypothetical protein 0.0049 0.021 0.0586
Schistosoma mansoni amine GPCR 0.0078 0.0388 0.0948
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0165 0.0915 0.1739
Loa Loa (eye worm) ACC-1 protein 0.0098 0.0507 0.1415
Onchocerca volvulus 0.0045 0.0187 0.0738
Echinococcus multilocularis somatostatin receptor 0.0078 0.0388 0.0738
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0078 0.0388 0.0948
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0472 0.2777 0.6787
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0218 0.0415
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0388 0.0738
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0051 0.022 0.0418
Brugia malayi intermediate filament protein 0.0027 0.0076 0.0238
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0049 0.021 0.1397
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0016 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0019
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.0388 0.0738
Echinococcus granulosus survival motor neuron protein 1 0.0475 0.2798 0.5318
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0045 0.0187 0.0596
Schistosoma mansoni survival motor neuron protein 0.0097 0.0501 0.1224
Loa Loa (eye worm) TYRA-2 protein 0.0078 0.0388 0.1083
Trypanosoma brucei heat shock protein, putative 0.0046 0.019 0.1259
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.0104 0.0198
Onchocerca volvulus 0.0098 0.0507 0.2092
Trypanosoma brucei heat shock protein 84, putative 0.003 0.0097 0.0632
Schistosoma mansoni amine GPCR 0.0078 0.0388 0.0948
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0032 0.0104 0.033
Brugia malayi hypothetical protein 0.0475 0.2798 0.9038
Loa Loa (eye worm) hypothetical protein 0.0045 0.0187 0.0521
Trypanosoma brucei oxidoreductase-like protein 0.012 0.0642 0.4307
Leishmania major heat shock protein 83-1 0.0046 0.019 0.1259
Loa Loa (eye worm) hypothetical protein 0.0053 0.0233 0.0649
Schistosoma mansoni jun-related protein 0.0134 0.0727 0.1777
Brugia malayi Cation transporter family protein 0.0472 0.2777 0.8972
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0915 0.087
Echinococcus granulosus nAChR subunit 0.0098 0.0507 0.0963
Onchocerca volvulus Putative nachr subunit 0.0098 0.0507 0.2092
Loa Loa (eye worm) hypothetical protein 0.0078 0.0388 0.1083
Loa Loa (eye worm) hypothetical protein 0.0078 0.0388 0.1083
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0357 0.2081 0.6719
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0113 0.0595 0.0496
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0078 0.0388 0.0948
Leishmania major pteridine reductase 1 0.012 0.0642 0.4307
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0032 0.0104 0.0682
Brugia malayi hypothetical protein 0.0016 0.0012 0.0032
Brugia malayi larval opioid receptor 0.0078 0.0388 0.1248
Loa Loa (eye worm) acyl carrier protein 0.0052 0.0227 0.0634
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0076 0.0211
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0078 0.0388 0.0738
Schistosoma mansoni nAChR subunit 0.0098 0.0507 0.1239
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.0104 0.0055
Loa Loa (eye worm) hypothetical protein 0.0045 0.0187 0.0521
Echinococcus multilocularis carbonyl reductase 1 0.0021 0.0037 0.007
Schistosoma mansoni nAChR subunit 0.0098 0.0507 0.1239
Trypanosoma brucei prostaglandin f synthase 0.0032 0.0104 0.0682
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0033
Giardia lamblia Grp94/Hsp90 0.0043 0.0173 0.7301
Loa Loa (eye worm) hypothetical protein 0.0078 0.0388 0.1083
Brugia malayi nuclear receptor NHR-67 0.0016 0.0012 0.0032
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.0388 0.0738
Schistosoma mansoni neurotransmitter gated ion channel 0.0045 0.0187 0.0456
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0113 0.0595 0.0496
Mycobacterium tuberculosis Meromycolate extension acyl carrier protein AcpM 0.0052 0.0227 0.0124
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0098 0.0507 0.1415
Loa Loa (eye worm) hypothetical protein 0.0045 0.0187 0.0521
Echinococcus granulosus lamin 0.0027 0.0076 0.0144
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0218 0.1452
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.0104 0.0198
Loa Loa (eye worm) hypothetical protein 0.0078 0.0388 0.1083
Brugia malayi Protein phosphatase 2C containing protein 0.0023 0.0049 0.0153
Loa Loa (eye worm) melatonin receptor type 1A 0.0078 0.0388 0.1083
Schistosoma mansoni hypothetical protein 0.0097 0.0501 0.1224
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0042 0.0165 0.0314
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0183 0.0348
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0018 0.0024 0.0045
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0191 0.0142
Leishmania major oxidoreductase-like protein 0.012 0.0642 0.4307
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0053 0.0233 0.0745
Echinococcus granulosus fmrfamide receptor 0.0078 0.0388 0.0738
Trypanosoma cruzi Heat shock protein 83, putative 0.0046 0.019 0.1259
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.0104 0.0198
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0218 0.0609
Echinococcus granulosus snurportin 1 0.0605 0.3583 0.681
Echinococcus granulosus GTP binding nuclear protein Ran 0.0042 0.0165 0.0314
Schistosoma mansoni hypothetical protein 0.0605 0.3583 0.8757
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0034 0.0096
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0035 0.0123 0.0392
Echinococcus multilocularis dro:myosuppressin receptor 0.0078 0.0388 0.0738
Loa Loa (eye worm) hypothetical protein 0.0078 0.0388 0.1083
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0007 0.0013
Brugia malayi G protein-coupled receptor F59B2.13 0.0078 0.0388 0.1248
Echinococcus multilocularis g protein coupled receptor 0.0078 0.0388 0.0738
Entamoeba histolytica aldose reductase, putative 0.0032 0.0104 0.1003
Loa Loa (eye worm) hypothetical protein 0.0078 0.0388 0.1083
Schistosoma mansoni RAR-like nuclear receptor 0.0035 0.0123 0.0302
Echinococcus granulosus heat shock protein 90 0.0046 0.019 0.0361
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0365 0.2129 0.5202
Loa Loa (eye worm) hypothetical protein 0.0045 0.0187 0.0521
Loa Loa (eye worm) hypothetical protein 0.0078 0.0388 0.1083
Entamoeba histolytica hypothetical protein 0.0036 0.013 0.148
Echinococcus multilocularis neuropeptide FF receptor 2 0.0078 0.0388 0.0738
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0078 0.0388 0.1248
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0113 0.0595 0.3992
Loa Loa (eye worm) hypothetical protein 0.0098 0.0507 0.1415
Echinococcus multilocularis nAChR subunit 0.0098 0.0507 0.0963
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0098 0.0507 0.1632
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0078 0.0388 0.0738
Brugia malayi Serotonin receptor 0.0524 0.3095 1
Echinococcus multilocularis neuropeptide s receptor 0.0078 0.0388 0.0738
Echinococcus granulosus glycine receptor subunit alpha 1 0.0472 0.2777 0.5279
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0013 0.0025
Leishmania major heat shock protein 83-1 0.0046 0.019 0.1259
Brugia malayi hypothetical protein 0.0078 0.0388 0.1248
Schistosoma mansoni coup transcription factor 0.0035 0.0123 0.0302
Loa Loa (eye worm) hypothetical protein 0.0078 0.0388 0.1083
Mycobacterium ulcerans phytoene synthase, CrtB 0.0081 0.0403 0.0302
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0817 0.4874 0.482
Brugia malayi hypothetical protein 0.0018 0.0024 0.007
Leishmania major heat shock protein 83-1 0.0046 0.019 0.1259
Onchocerca volvulus 0.0032 0.0104 0.039
Trypanosoma cruzi protein phosphatase 2C, putative 0.0023 0.0049 0.0314
Brugia malayi nuclear hormone receptor family member nhr-6 0.0016 0.0012 0.0032
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0012 0.0032
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0183 0.0348
Plasmodium falciparum heat shock protein 90, putative 0.0027 0.0074 0.0024
Schistosoma mansoni zinc finger protein 0.0015 0.0003 0.0007
Schistosoma mansoni heat shock protein 0.0046 0.019 0.0464
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0256 0.1706
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0113 0.0595 0.0549
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0035 0.0123 0.0302
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0098 0.0507 0.1415
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0218 0.1452
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0078 0.0388 0.0948
Entamoeba histolytica hypothetical protein 0.0053 0.0233 0.3356
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0042 0.0165 0.0117
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0078 0.0388 0.0948
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.021 0.0162
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0136 0.0901
Brugia malayi Dopamine receptor protein 1 0.0078 0.0388 0.1248
Onchocerca volvulus 0.0078 0.0388 0.159
Schistosoma mansoni ap endonuclease 0.0037 0.0136 0.0333
Echinococcus multilocularis fmrfamide receptor 0.0078 0.0388 0.0738
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.0104 0.0055
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0419 0.2457 0.467
Loa Loa (eye worm) hypothetical protein 0.0078 0.0388 0.1083
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0078 0.0388 0.1083
Plasmodium falciparum endoplasmin, putative 0.0033 0.0114 0.0065
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0035 0.0123 0.0235
Plasmodium vivax heat shock protein 86, putative 0.0046 0.019 0.0141
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0098 0.0507 0.0963
Echinococcus multilocularis carbonyl reductase 1 0.0021 0.0037 0.007
Giardia lamblia Aldose reductase 0.0032 0.0104 0.324
Leishmania major heat shock protein 83-1 0.0046 0.019 0.1259
Brugia malayi Hsp90 protein 0.003 0.0097 0.0306
Toxoplasma gondii Hsp90 domain-containing protein 0.0173 0.0964 0.0919
Plasmodium vivax heat shock protein 90, putative 0.003 0.0097 0.0047
Schistosoma mansoni amine GPCR 0.0078 0.0388 0.0948
Echinococcus granulosus thyroid hormone receptor alpha 0.0016 0.0012 0.0022
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0098 0.0507 0.1415
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0098 0.0507 0.1239
Echinococcus multilocularis protein phosphatase 2C 0.0023 0.0049 0.0094
Onchocerca volvulus 0.0045 0.0187 0.0738
Echinococcus granulosus heat shock protein 90 0.0039 0.015 0.0284
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0113 0.0595 0.0496
Loa Loa (eye worm) protein phosphatase 2C containing protein 0.0175 0.0974 0.2717
Schistosoma mansoni alpha-1 adrenergic receptor 0.0078 0.0388 0.0948
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0113 0.0595 0.3992
Brugia malayi Serotonin receptor 0.0078 0.0388 0.1248
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0078 0.0388 0.0738
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0042 0.0165 0.0117
Loa Loa (eye worm) oxidoreductase 0.0032 0.0104 0.029
Echinococcus multilocularis aryl hydrocarbon receptor 0.0408 0.2389 0.454
Loa Loa (eye worm) hypothetical protein 0.0035 0.0123 0.0344
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0033
Schistosoma mansoni hypothetical protein 0.0016 0.0007 0.0017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0035 0.0123 0.0344
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0066
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.0642 0.0544
Mycobacterium ulcerans short chain dehydrogenase 0.0113 0.0595 0.0496
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0113 0.0595 0.1918
Echinococcus multilocularis g-protein coupled receptor 0.0078 0.0388 0.0738
Entamoeba histolytica heat shock protein 90, putative 0.0046 0.019 0.2571
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0045 0.0187 0.0596
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0078 0.0388 0.1248
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0045 0.0187 0.0521
Plasmodium falciparum acyl carrier protein 0.0052 0.0227 0.0179
Onchocerca volvulus 0.0098 0.0507 0.2092
Schistosoma mansoni importin beta-1 0.0057 0.0256 0.0626
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0013 0.0032
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0078 0.0388 0.0948
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0056 0.025 0.0024
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0419 0.2457 0.7936
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0084 0.0264
Schistosoma mansoni hypothetical protein 0.002 0.0034 0.0084
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0915 0.087
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0212 0.0678
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0113 0.0595 0.0496
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0032 0.0104 0.0056
Mycobacterium ulcerans short chain dehydrogenase 0.0113 0.0595 0.0496
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0218 0.1452
Brugia malayi ecdysteroid receptor 0.0035 0.0123 0.0392
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0037
Echinococcus multilocularis survival motor neuron protein 1 0.0475 0.2798 0.5318
Loa Loa (eye worm) hypothetical protein 0.0078 0.0388 0.1083
Schistosoma mansoni dihydropteridine reductase 0.0113 0.0595 0.1455
Loa Loa (eye worm) hypothetical protein 0.0098 0.0507 0.1415
Brugia malayi Bromodomain containing protein 0.0073 0.0356 0.1145
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0035 0.0123 0.0392
Brugia malayi hypothetical protein 0.0078 0.0388 0.1248
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0113 0.0595 0.3992
Leishmania major protein kinase, putative 0.005 0.0213 0.1416
Schistosoma mansoni lamin 0.0027 0.0076 0.0185
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0045 0.0187 0.0596
Trichomonas vaginalis importin beta-1, putative 0.0046 0.0191 0.0142
Wolbachia endosymbiont of Brugia malayi acyl carrier protein 0.0052 0.0227 0.0092
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.0052 0.0227 0.0727
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0136 0.0088
Echinococcus multilocularis transfer RNA-Lys 0.014 0.0761 0.1446
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0035 0.0123 0.0392
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0013 0.0025
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0472 0.2777 0.5279
Onchocerca volvulus Glucosylceramidase homolog 0.0165 0.0915 0.3817
Loa Loa (eye worm) hypothetical protein 0.0034 0.0117 0.0326
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0388 0.0948
Echinococcus multilocularis aldo keto reductase 0.0032 0.0104 0.0198
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0035 0.0123 0.0302
Brugia malayi sulfakinin receptor protein 0.0078 0.0388 0.1248
Brugia malayi bZIP transcription factor family protein 0.0165 0.0915 0.2951
Echinococcus multilocularis heat shock protein 0.0046 0.019 0.0361
Echinococcus multilocularis musashi 0.0027 0.0076 0.0144
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.012 0.0642 0.0544
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0218 0.017
Brugia malayi Dopamine receptor protein 2 0.0078 0.0388 0.1248
Schistosoma mansoni neuropeptide receptor 0.0078 0.0388 0.0948
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0098 0.0507 0.0963
Echinococcus granulosus neuropeptides capa receptor 0.0078 0.0388 0.0738
Leishmania major heat shock protein 83-1 0.0046 0.019 0.1259
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0035 0.0123 0.0235
Loa Loa (eye worm) oxidoreductase 0.0032 0.0104 0.029
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0016 0.0012 0.0029
Echinococcus granulosus protein phosphatase 2c 0.0023 0.0049 0.0094
Entamoeba histolytica aldose reductase, putative 0.0032 0.0104 0.1003
Schistosoma mansoni hypothetical protein 0.0016 0.0007 0.0017
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0012 0.0022
Echinococcus granulosus protein phosphatase 1b 0.0153 0.0839 0.1595
Loa Loa (eye worm) hypothetical protein 0.0078 0.0388 0.1083
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0078 0.0388 0.0948
Trypanosoma brucei heat shock protein 90, putative 0.0046 0.019 0.1259
Trypanosoma brucei heat shock protein, putative 0.0046 0.019 0.1259
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0051 0.022 0.0614
Toxoplasma gondii exonuclease III APE 0.0037 0.0136 0.0088
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.0388 0.0738
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0098 0.0507 0.1632
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0266 0.0505
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0113 0.0595 0.0496
Onchocerca volvulus 0.0078 0.0388 0.159
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0035 0.0123 0.0392
Brugia malayi hypothetical protein 0.0049 0.021 0.0673
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0053 0.0233 0.0568
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0035 0.0123 0.0344
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0098 0.0507 0.1632
Echinococcus multilocularis glycine receptor subunit beta 0.0472 0.2777 0.5279
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.0081 0.0403 0.0302
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0098 0.0507 0.0963
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0218 0.0415
Loa Loa (eye worm) hypothetical protein 0.0027 0.0076 0.0211
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0049 0.021 0.1397
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0033
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.0104 0.0198
Onchocerca volvulus 0.0098 0.0507 0.2092
Schistosoma mansoni adenoreceptor 0.0078 0.0388 0.0948
Echinococcus granulosus protein phosphatase 2c 0.0023 0.0049 0.0094
Loa Loa (eye worm) hypothetical protein 0.0078 0.0388 0.1083
Schistosoma mansoni microtubule-associated protein tau 0.0688 0.4092 1
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0049 0.021 0.0162
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0049 0.021 0.1397
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.012 0.0642 0.0544
Onchocerca volvulus 0.0098 0.0507 0.2092
Brugia malayi G protein-coupled receptor 0.0078 0.0388 0.1248
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0078 0.0388 0.0738
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.0138
Echinococcus granulosus g-protein coupled receptor 0.0078 0.0388 0.0738
Leishmania major heat shock protein 83-1 0.0046 0.019 0.1259
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.1441 0.1398
Trypanosoma brucei pteridine reductase 1 0.0113 0.0595 0.3992
Schistosoma mansoni nuclear receptor 0.0016 0.0012 0.0029
Echinococcus multilocularis aldo keto reductase 0.0032 0.0104 0.0198
Loa Loa (eye worm) hypothetical protein 0.0035 0.0123 0.0344
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0218 0.017
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.0388 0.0738
Brugia malayi Cation transporter family protein 0.0098 0.0507 0.1632
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0165 0.1095
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0098 0.0507 0.0963
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0218 1
Brugia malayi follicle stimulating hormone receptor 0.0078 0.0388 0.1248
Schistosoma mansoni single-minded 0.0189 0.1059 0.2587
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0035 0.0123 0.0392
Loa Loa (eye worm) hypothetical protein 0.0098 0.0507 0.1415
Loa Loa (eye worm) hypothetical protein 0.0196 0.1105 0.3083
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0183 0.051
Brugia malayi nuclear receptor NHR-88 0.0016 0.0012 0.0032
Trichomonas vaginalis endoplasmin, putative 0.0033 0.0114 0.0065
Loa Loa (eye worm) hypothetical protein 0.0098 0.0507 0.1415
Loa Loa (eye worm) hypothetical protein 0.0472 0.2777 0.7751
Echinococcus granulosus PP-binding domain containing protein 0.0038 0.0143 0.0272
Loa Loa (eye worm) hypothetical protein 0.0365 0.2129 0.594
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0388 0.0738
Loa Loa (eye worm) hypothetical protein 0.0098 0.0507 0.1415
Trypanosoma cruzi Acyl carrier protein, mitochondrial, putative 0.0052 0.0227 0.1511
Onchocerca volvulus 0.0027 0.0076 0.0269
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0388 0.0948
Brugia malayi Melatonin receptor type 1A 0.0078 0.0388 0.1248
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0218 0.017
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0016 0.0012 0.0029
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0016 0.0012 0.0032
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.0104 0.0198
Brugia malayi Dopamine receptor 0.0078 0.0388 0.1248
Onchocerca volvulus 0.013 0.07 0.2906
Trypanosoma brucei heat shock protein, putative 0.0046 0.019 0.1259
Schistosoma mansoni amine GPCR 0.0399 0.2337 0.5712
Schistosoma mansoni nuclear hormone receptor 0.0035 0.0123 0.0302
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0098 0.0507 0.1632
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0078 0.0388 0.0738
Trypanosoma brucei protein kinase, putative 0.005 0.0218 0.1452
Echinococcus multilocularis neuropeptide receptor 0.0078 0.0388 0.0738
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0113 0.0595 1
Echinococcus multilocularis g protein coupled receptor 0.0078 0.0388 0.0738
Loa Loa (eye worm) retinol dehydrogenase 12 0.0113 0.0595 0.1662
Trichomonas vaginalis aldo/keto reductase, putative 0.0032 0.0104 0.0055
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0007 0.0013
Mycobacterium ulcerans short chain dehydrogenase 0.0113 0.0595 0.0496
Trypanosoma cruzi phytoene synthase, putative 0.0081 0.0403 0.2697
Trypanosoma cruzi protein phosphatase 2C-like, putative 0.0023 0.0049 0.0314
Echinococcus granulosus hypothetical protein 0.0747 0.4449 0.8456
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0183 0.0447
Mycobacterium ulcerans short chain dehydrogenase 0.0113 0.0595 0.0496
Trypanosoma cruzi squalene synthase, putative 0.0259 0.1487 1
Echinococcus multilocularis heat shock protein 90 0.0039 0.015 0.0284
Plasmodium vivax enoyl-acyl carrier protein reductase 0.1661 1 1
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0113 0.0595 0.0496
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0427 0.2503 0.8085
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0113 0.0595 0.0465
Brugia malayi tailless protein 0.0016 0.0012 0.0032
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0078 0.0388 0.0738
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0183 0.0447
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0113 0.0595 0.1918
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.1441 0.1398
Brugia malayi hypothetical protein 0.0036 0.013 0.0414
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0817 0.4874 0.4849
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0136 0.0033
Loa Loa (eye worm) hypothetical protein 0.0078 0.0388 0.1083
Toxoplasma gondii aldose reductase, putative 0.0032 0.0104 0.0055
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.0113 0.0595 0.055
Plasmodium falciparum heat shock protein 90, putative 0.0173 0.0964 0.0919
Trypanosoma brucei aldo-keto reductase, putative 0.0032 0.0104 0.0682
Loa Loa (eye worm) hypothetical protein 0.0078 0.0388 0.1083
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.0104 0.0055
Loa Loa (eye worm) steroid hormone receptor 0.0035 0.0123 0.0344
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0035 0.0123 0.0392
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0388 0.0948
Onchocerca volvulus 0.0141 0.0771 0.3206
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0212 0.0678
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0915 0.087
Brugia malayi hypothetical protein 0.0078 0.0388 0.1248
Trichomonas vaginalis guanylate cyclase, putative 0.0049 0.021 0.0162
Loa Loa (eye worm) hypothetical protein 0.0098 0.0507 0.1415
Plasmodium vivax importin-beta 2, putative 0.0057 0.0256 0.0208
Plasmodium falciparum enoyl-acyl carrier reductase 0.1661 1 1
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0113 0.0595 0.1132
Echinococcus granulosus neuropeptide Y receptor 0.0078 0.0388 0.0738
Onchocerca volvulus 0.0053 0.0233 0.0933
Onchocerca volvulus 0.0045 0.0187 0.0738
Brugia malayi Tachykinin-like peptides receptor 99D 0.0078 0.0388 0.1248
Loa Loa (eye worm) ACC-1 protein 0.0098 0.0507 0.1415
Echinococcus granulosus carbonyl reductase 1 0.0028 0.0084 0.0159
Trichomonas vaginalis aldo-keto reductase, putative 0.0032 0.0104 0.0055
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0078 0.0388 0.1248
Brugia malayi hypothetical protein 0.0045 0.0187 0.0596
Brugia malayi MH2 domain containing protein 0.0119 0.0635 0.2047
Echinococcus multilocularis Squalene phytoene synthase 0.0081 0.0403 0.0766
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0045 0.0187 0.0596
Leishmania major heat shock protein 83-1 0.0046 0.019 0.1259
Schistosoma mansoni bromodomain containing protein 0.0062 0.0287 0.0701
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0076 0.0238
Brugia malayi hypothetical protein 0.0018 0.0024 0.007
Loa Loa (eye worm) hypothetical protein 0.0078 0.0388 0.1083
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0472 0.2777 0.6787
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0033
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0113 0.0595 0.0496
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0388 0.0738
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0078 0.0388 0.0738
Echinococcus granulosus geminin 0.0502 0.2959 0.5625
Leishmania major heat shock protein 83-1 0.0046 0.019 0.1259
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.012 0.0642 0.0544
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0078 0.0388 0.0738
Trypanosoma cruzi squalene synthase, putative 0.0259 0.1487 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0388 0.1083
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.003 0.0097 0.0184
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.0104 0.0198
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0013 0.0032
Schistosoma mansoni nAChR subunit 0.0098 0.0507 0.1239
Echinococcus granulosus biogenic amine 5HT receptor 0.0078 0.0388 0.0738
Brugia malayi putative neuropeptide receptor 0.0078 0.0388 0.1248
Toxoplasma gondii HEAT repeat-containing protein 0.0057 0.0256 0.0208
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0045 0.0187 0.0355
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0183 0.0585
Schistosoma mansoni neuropeptide F-like receptor 0.0078 0.0388 0.0948
Onchocerca volvulus 0.0032 0.0104 0.039
Onchocerca volvulus 0.0078 0.0388 0.159
Trypanosoma brucei squalene synthase, putative 0.0259 0.1487 1
Loa Loa (eye worm) oxidoreductase 0.0032 0.0104 0.029
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0078 0.0388 0.0738
Brugia malayi ORL1-like opioid receptor 0.0078 0.0388 0.1248
Trypanosoma brucei heat shock protein, putative 0.0046 0.019 0.1259
Brugia malayi bHLH-PAS transcription factor 0.014 0.0761 0.2453
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0032 0.0104 0.0198
Onchocerca volvulus 0.0078 0.0388 0.159
Mycobacterium ulcerans short chain dehydrogenase 0.0113 0.0595 0.0496
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0136 0.0901
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0012 0.0022
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.1661 1 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0012 0.0022
Onchocerca volvulus 0.0078 0.0388 0.159
Leishmania major protein kinase, putative 0.005 0.0213 0.1416
Loa Loa (eye worm) hypothetical protein 0.0078 0.0388 0.1083
Brugia malayi hypothetical protein 0.0045 0.0187 0.0596
Echinococcus granulosus aldo keto reductase 0.0032 0.0104 0.0198
Schistosoma mansoni neuropeptide receptor 0.0078 0.0388 0.0948
Brugia malayi nuclear receptor RXR 0.0018 0.0024 0.007
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.1441 0.1398
Entamoeba histolytica hypothetical protein 0.0036 0.013 0.148
Loa Loa (eye worm) hypothetical protein 0.0053 0.0233 0.0649
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0035 0.0123 0.0235
Onchocerca volvulus 0.0098 0.0507 0.2092
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0078 0.0388 0.1083
Echinococcus multilocularis serotonin receptor 0.0196 0.1105 0.21
Loa Loa (eye worm) hypothetical protein 0.0045 0.0187 0.0521
Brugia malayi MAP kinase sur-1 0.005 0.0218 0.0699
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0098 0.0507 0.1632
Loa Loa (eye worm) hypothetical protein 0.0053 0.0233 0.0649
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0915 0.087
Toxoplasma gondii acyl carrier protein ACP 0.0052 0.0227 0.0179
Trypanosoma cruzi aldo/keto reductase, putative 0.0032 0.0104 0.0682
Loa Loa (eye worm) hypothetical protein 0.0035 0.0123 0.0344
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0098 0.0507 0.1632
Loa Loa (eye worm) hypothetical protein 0.0113 0.0595 0.1662
Brugia malayi hypothetical protein 0.0016 0.0012 0.0032
Brugia malayi hypothetical protein 0.013 0.07 0.2255
Leishmania major hypothetical protein, conserved 0.0081 0.0403 0.2697
Echinococcus multilocularis sex peptide receptor 0.0078 0.0388 0.0738
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.1441 0.1398
Loa Loa (eye worm) hypothetical protein 0.0078 0.0388 0.1083
Echinococcus granulosus neuropeptide FF receptor 2 0.0078 0.0388 0.0738
Mycobacterium ulcerans heat shock protein 90 0.0043 0.0173 0.0069
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0881 0.5261 1
Plasmodium falciparum importin beta, putative 0.0057 0.0256 0.0208
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.013 0.0247
Echinococcus granulosus nAChR subunit 0.0053 0.0233 0.0442
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0035 0.0123 0.0471
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0043 0.0173 0.0037
Loa Loa (eye worm) hypothetical protein 0.004 0.0153 0.0428
Leishmania major heat shock protein 83-1 0.0046 0.019 0.1259
Loa Loa (eye worm) hypothetical protein 0.0081 0.0403 0.1125
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0024 0.0058
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0113 0.0595 0.0496
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0097 0.0501 0.1612
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.021 0.0162
Onchocerca volvulus 0.0113 0.0595 0.2466
Onchocerca volvulus 0.0032 0.0104 0.039
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.0104 0.0198
Schistosoma mansoni acetylcholine receptor subunit beta 0.0045 0.0187 0.0456
Loa Loa (eye worm) hypothetical protein 0.0078 0.0388 0.1083
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0113 0.0595 0.0496
Echinococcus multilocularis conserved hypothetical protein 0.0669 0.3973 0.7552
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0098 0.0507 0.1632
Loa Loa (eye worm) hypothetical protein 0.0078 0.0388 0.1083
Schistosoma mansoni thyroid hormone receptor 0.0035 0.0123 0.0302
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0136 0.0381
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0078 0.0388 0.0738
Leishmania major heat shock protein 83-1 0.0046 0.019 0.1259
Echinococcus multilocularis ecdysone induced protein 78C 0.0035 0.0123 0.0235
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0915 0.087
Brugia malayi probable protein phosphatase 2C 0.0023 0.0049 0.0153
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.0388 0.0738
Leishmania major protein phosphatase 2C, putative 0.0023 0.0049 0.0314
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0113 0.0595 0.3992
Echinococcus granulosus orexin receptor type 2 0.0078 0.0388 0.0738
Echinococcus granulosus glycine receptor subunit beta 0.0472 0.2777 0.5279
Trichomonas vaginalis adenylate cyclase, putative 0.0049 0.021 0.0162
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0113 0.0595 0.1132
Loa Loa (eye worm) heat shock protein 75 0.003 0.0097 0.0269
Schistosoma mansoni neurotransmitter gated ion channel 0.0045 0.0187 0.0456
Schistosoma mansoni biogenic amine receptor 0.0078 0.0388 0.0948
Brugia malayi neuropeptide F receptor 0.0078 0.0388 0.1248
Loa Loa (eye worm) hypothetical protein 0.0045 0.0187 0.0521
Loa Loa (eye worm) hypothetical protein 0.0049 0.0212 0.0591
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0098 0.0507 0.1415
Echinococcus granulosus dro:myosuppressin receptor 0.0078 0.0388 0.0738
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0049 0.021 0.0162
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0035 0.0123 0.0392
Schistosoma mansoni retinoic acid receptor RXR 0.0035 0.0123 0.0302
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0098 0.0507 0.0963
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0136 0.1596
Onchocerca volvulus Putative protein phosphatase 2C 0.0023 0.0049 0.0158
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0007 0.0016
Entamoeba histolytica heat shock protein 90, putative 0.0046 0.019 0.2571
Loa Loa (eye worm) hypothetical protein 0.0098 0.0507 0.1415
Loa Loa (eye worm) hypothetical protein 0.0057 0.0256 0.0715
Onchocerca volvulus 0.0022 0.0043 0.0131
Loa Loa (eye worm) neuropeptide F receptor 0.0078 0.0388 0.1083
Echinococcus granulosus zinc finger protein 0.0019 0.0028 0.0053
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0042 0.0165 0.0528
Schistosoma mansoni nAChR subunit 0.0098 0.0507 0.1239
Echinococcus granulosus glycine receptor subunit alpha 1 0.0472 0.2777 0.5279
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0033
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0388 0.0738
Echinococcus multilocularis aldehyde reductase 0.0022 0.0048 0.0092
Echinococcus multilocularis importin subunit beta 1 0.0057 0.0256 0.0487
Echinococcus multilocularis protein phosphatase 1b 0.0153 0.0839 0.1595
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0035 0.0123 0.0235
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0032 0.0104 0.0055
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0388 0.0948
Trichomonas vaginalis heat shock protein, putative 0.0043 0.0173 0.0124
Brugia malayi G-protein coupled receptor 0.0078 0.0388 0.1248
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0032 0.0104 0.0198
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0078 0.0388 0.0948
Echinococcus multilocularis neuropeptide receptor 0.0078 0.0388 0.0738
Leishmania major squalene synthase, putative 0.0259 0.1487 1
Schistosoma mansoni protein phosphatase 2c gamma 0.0023 0.0049 0.012
Loa Loa (eye worm) hypothetical protein 0.0053 0.0233 0.0649
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0098 0.0507 0.1632
Leishmania major heat shock protein 83-1 0.0046 0.019 0.1259
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0035 0.0123 0.0392
Loa Loa (eye worm) hypothetical protein 0.0069 0.0331 0.0923
Giardia lamblia Aldose reductase 0.0032 0.0104 0.324
Loa Loa (eye worm) hypothetical protein 0.0045 0.0187 0.0521

Activities

Activity type Activity value Assay description Source Reference
Control (functional) = 272 % Diuretic activity in rat was determined by measuring urine volume at a dose of 10 mg/kg upon oral administration ChEMBL. No reference
Control (functional) = 280 % Diuretic activity in rat was determined by measuring sodium excretion at a dose of 10 mg/kg upon oral administration ChEMBL. No reference
IC50 (functional) = 0.56 nM Inhibition of adenosine induced negative inotropic activity against guinea-pig atria (Adenosine A1 receptor) ChEMBL. No reference
IC50 (functional) = 0.56 nM Inhibition of adenosine induced negative inotropic activity against guinea-pig atria (Adenosine A1 receptor) ChEMBL. No reference
IC50 (binding) = 17.2 nM Inhibition of [3H]-CHA binding against Adenosine A1 receptors of rat cortical membranes ChEMBL. No reference
IC50 (binding) = 17.2 nM Inhibition of [3H]-CHA binding against Adenosine A1 receptors of rat cortical membranes ChEMBL. No reference
IC50 (functional) = 1180 nM Compound was evaluated for inhibition of adenosine induced relaxation against guinea-pig aorta (Adenosine A2 receptor). ChEMBL. No reference
IC50 (functional) = 1180 nM Compound was evaluated for inhibition of adenosine induced relaxation against guinea-pig aorta (Adenosine A2 receptor). ChEMBL. No reference
IC50 (binding) = 11300 nM Inhibition of [3H]-NECA specific binding against Adenosine A2 receptors of rat striatal membranes ChEMBL. No reference
IC50 (binding) = 11300 nM Inhibition of [3H]-NECA specific binding against Adenosine A2 receptors of rat striatal membranes ChEMBL. No reference
Ratio (binding) = 657 Ratio A2 receptor binding inhibitory activity to A1 receptor binding inhibitory activity ChEMBL. No reference
Ratio (functional) = 2017 Ratio of inhibition of adenosine receptor antagonism activities (A2/A1) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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