Detailed information for compound 1036790

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 323.858 | Formula: C18H26ClNO2
  • H donors: 0 H acceptors: 1 LogP: 4.2 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(CCCC1(C)OC=C(C1=O)c1ccccc1)CC.Cl
  • InChi: 1S/C18H25NO2.ClH/c1-4-19(5-2)13-9-12-18(3)17(20)16(14-21-18)15-10-7-6-8-11-15;/h6-8,10-11,14H,4-5,9,12-13H2,1-3H3;1H
  • InChiKey: QVDIWIVCIHYJNK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens dopamine receptor D2 Starlite/ChEMBL No references
Homo sapiens sigma non-opioid intracellular receptor 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania infantum C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania braziliensis C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131051 All targets in OG5_131051
Candida albicans sterol C8-C7 isomerase Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma congolense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Brugia malayi ERG2 and Sigma1 receptor like protein Get druggable targets OG5_131051 All targets in OG5_131051
Candida albicans sterol C8-C7 isomerase Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma congolense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma cruzi C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania major C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma brucei C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania donovani C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma brucei gambiense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania mexicana C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae Probable lipase LipE 0.0293 0.1426 1
Brugia malayi jmjC domain containing protein 0.0029 0.0047 0.0054
Brugia malayi Latrophilin receptor protein 2 0.0277 0.1344 0.152
Plasmodium falciparum importin beta, putative 0.0058 0.0197 0.019
Loa Loa (eye worm) hypothetical protein 0.0445 0.222 0.2511
Schistosoma mansoni ran 0.0042 0.0117 0.0133
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0087 0.0351 0.0339
Echinococcus multilocularis jumonji domain containing protein 0.0125 0.0549 0.0621
Trypanosoma brucei DNA polymerase kappa, putative 0.0241 0.1157 0.1279
Entamoeba histolytica hexokinase 2 0.1712 0.8844 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.014 0.014
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0088 0.0356 0.0371
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0028 0.0042 0.0047
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0047 0.0054
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0293 0.1426 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.002 0.0002 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0241 0.1157 0.1279
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1698 0.8774 0.9921
Brugia malayi jmjC domain containing protein 0.0029 0.0047 0.0054
Loa Loa (eye worm) hypothetical protein 0.0241 0.1157 0.1308
Loa Loa (eye worm) TAR-binding protein 0.0071 0.0267 0.0302
Brugia malayi polk-prov protein 0.0075 0.0287 0.0325
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0277 0.1344 0.152
Plasmodium vivax hypothetical protein, conserved 0.009 0.0365 0.0381
Schistosoma mansoni DNA polymerase IV / kappa 0.0075 0.0287 0.0325
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0293 0.1426 0.1612
Trichomonas vaginalis set domain proteins, putative 0.1933 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0241 0.1157 0.1279
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0387 0.0437
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0068 0.0251 0.0252
Schistosoma mansoni hypothetical protein 0.0041 0.011 0.0125
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.009 0.0365 0.0413
Schistosoma mansoni smad1 5 8 and 0.0068 0.0252 0.0285
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0293 0.1426 0.1612
Trypanosoma cruzi hypothetical protein, conserved 0.0293 0.1426 0.1612
Schistosoma mansoni Smad4 0.003 0.0055 0.0062
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0056
Echinococcus multilocularis hexokinase 0.1712 0.8844 1
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0287 0.0325
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0387 0.0437
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0068 0.0251 0.0284
Loa Loa (eye worm) hypothetical protein 0.0293 0.1426 0.1612
Brugia malayi mothers against decapentaplegic homolog 3 0.003 0.0055 0.0062
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0029 0.0049 0.0023
Schistosoma mansoni DNA polymerase eta 0.0241 0.1157 0.1308
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0244 0.1169 0.1322
Onchocerca volvulus 0.1712 0.8844 0.8844
Loa Loa (eye worm) DIX domain-containing protein 0.0028 0.0042 0.0047
Brugia malayi jmjC domain containing protein 0.0029 0.0047 0.0054
Leishmania major C-8 sterol isomerase-like protein 0.0445 0.222 0.2486
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0241 0.1157 0.1308
Echinococcus granulosus JmjC domain containing protein 4 0.0029 0.0047 0.0054
Brugia malayi hexokinase 0.1712 0.8844 1
Toxoplasma gondii hexokinase 0.1712 0.8844 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0241 0.1157 0.1279
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0241 0.1157 0.1279
Loa Loa (eye worm) hexokinase type II 0.1712 0.8844 1
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0445 0.222 0.2511
Loa Loa (eye worm) hypothetical protein 0.0875 0.4472 0.5057
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.002 0.0002 0.0002
Echinococcus multilocularis dna polymerase eta 0.0241 0.1157 0.1308
Trypanosoma brucei DNA polymerase kappa, putative 0.0075 0.0287 0.0293
Entamoeba histolytica Ran family GTPase 0.0042 0.0117 0.0133
Leishmania major GTP-binding protein, putative 0.0042 0.0117 0.01
Brugia malayi beta-lactamase family protein 0.0293 0.1426 0.1612
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0241 0.1157 0.1308
Echinococcus granulosus segment polarity protein dishevelled 0.0028 0.0042 0.0047
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0028 0.0042 0.0042
Giardia lamblia DINP protein human, muc B family 0.0241 0.1157 1
Echinococcus multilocularis hexokinase 0.1712 0.8844 1
Brugia malayi regulator of G-protein signaling egl-10 0.0028 0.0042 0.0047
Loa Loa (eye worm) Smad1 0.0068 0.0252 0.0285
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0002 0.0002
Brugia malayi F/Y-rich N-terminus family protein 0.0038 0.0096 0.0109
Loa Loa (eye worm) beta-glucuronidase 0.0163 0.075 0.0848
Echinococcus multilocularis beta LACTamase domain containing family member 0.0293 0.1426 0.1612
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0294 0.1432 0.162
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0294 0.1432 0.162
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0087 0.0351 0.2172
Loa Loa (eye worm) hypothetical protein 0.0573 0.289 0.3268
Brugia malayi MH1 domain containing protein 0.0068 0.0252 0.0285
Echinococcus granulosus importin subunit beta 1 0.0058 0.0197 0.0222
Brugia malayi beta-lactamase 0.0293 0.1426 0.1612
Entamoeba histolytica hypothetical protein 0.0039 0.01 0.0113
Schistosoma mansoni Smad4 0.0068 0.0252 0.0285
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0024 0.0022 0.0024
Trichomonas vaginalis bromodomain-containing protein, putative 0.0088 0.0356 0.0356
Schistosoma mansoni protein phosphatase 2C 0.0029 0.0047 0.0054
Trichomonas vaginalis esterase, putative 0.0293 0.1426 0.1426
Echinococcus granulosus histone acetyltransferase KAT2B 0.0088 0.0356 0.0402
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0087 0.0351 0.0559
Toxoplasma gondii ABC1 family protein 0.0293 0.1426 0.1584
Loa Loa (eye worm) hypothetical protein 0.0544 0.2741 0.3099
Echinococcus granulosus peptidase Clp S14 family 0.0057 0.0194 0.022
Brugia malayi Hexokinase family protein 0.1074 0.5509 0.623
Loa Loa (eye worm) hypothetical protein 0.0035 0.0081 0.0091
Brugia malayi MH1 domain containing protein 0.0038 0.0093 0.0105
Brugia malayi RNA, U transporter 1 0.0164 0.0751 0.0849
Trichomonas vaginalis D-aminoacylase, putative 0.0293 0.1426 0.1426
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0267 0.0302
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0387 0.0437
Plasmodium vivax hypothetical protein, conserved 0.0293 0.1426 0.1584
Schistosoma mansoni regulator of G protein signaling 0.0028 0.0042 0.0047
Plasmodium falciparum DNA repair protein REV1, putative 0.0075 0.0287 0.0293
Echinococcus granulosus jumonji domain containing protein 0.0125 0.0549 0.0621
Schistosoma mansoni hypothetical protein 0.0039 0.01 0.0113
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0028 0.0042 0.0047
Plasmodium vivax SET domain protein, putative 0.0244 0.1169 0.1294
Trypanosoma brucei hypothetical protein, conserved 0.0293 0.1426 0.1584
Trypanosoma brucei DNA polymerase IV, putative 0.0241 0.1157 0.1279
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.002 0.0002 0.0002
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.005 0.0159 0.0159
Brugia malayi acetyltransferase, GNAT family protein 0.0299 0.146 0.1651
Leishmania major DNA damage repair protein, putative 0.0075 0.0287 0.0293
Brugia malayi hexokinase type II 0.0544 0.2741 0.3099
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0068 0.0251 0.0252
Brugia malayi DIX domain containing protein 0.0028 0.0042 0.0047
Echinococcus granulosus Pleckstrin G protein interacting region 0.0028 0.0042 0.0047
Echinococcus multilocularis peptidase Clp (S14 family) 0.0057 0.0194 0.022
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0029 0.0047 0.0054
Trichomonas vaginalis penicillin-binding protein, putative 0.0293 0.1426 0.1426
Trypanosoma cruzi hexokinase, putative 0.1712 0.8844 1
Schistosoma mansoni hypothetical protein 0.0277 0.1344 0.152
Trypanosoma brucei DNA polymerase kappa, putative 0.0166 0.0765 0.0835
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0087 0.0351 0.5
Plasmodium falciparum JmjC domain-containing protein, putative 0.0029 0.0047 0.0021
Mycobacterium tuberculosis Conserved protein 0.0293 0.1426 0.13
Brugia malayi hypothetical protein 0.0039 0.01 0.0113
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0087 0.0351 0.0365
Loa Loa (eye worm) MH1 domain-containing protein 0.003 0.0055 0.0062
Leishmania major hexokinase, putative 0.1712 0.8844 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0185 0.0865 0.0978
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0244 0.1169 0.1322
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0875 0.4472 0.5057
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0287 0.0325
Trypanosoma brucei DNA polymerase IV, putative 0.0241 0.1157 0.1279
Brugia malayi jmjC domain containing protein 0.0294 0.1432 0.162
Brugia malayi MH2 domain containing protein 0.0068 0.0252 0.0285
Onchocerca volvulus 0.0244 0.1169 0.1169
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0042 0.0117 0.0133
Trypanosoma brucei unspecified product 0.0166 0.0765 0.0835
Echinococcus multilocularis hyperpolarization activated cyclic 0.002 0.0002 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0241 0.1157 0.1279
Echinococcus granulosus hyperpolarization activated cyclic 0.002 0.0002 0.0002
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0445 0.222 0.2511
Echinococcus multilocularis smad 0.0068 0.0252 0.0285
Treponema pallidum hexokinase (hxk) 0.1712 0.8844 1
Schistosoma mansoni beta-mannosidase 0.0163 0.075 0.0848
Trypanosoma cruzi hypothetical protein, conserved 0.0293 0.1426 0.1612
Loa Loa (eye worm) transcription factor SMAD2 0.0999 0.512 0.579
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0088 0.0356 0.0371
Brugia malayi jmjC domain containing protein 0.0029 0.0047 0.0054
Brugia malayi Glycosyl hydrolases family 2, sugar binding domain containing protein 0.0177 0.0821 0.0928
Loa Loa (eye worm) hypothetical protein 0.0025 0.0029 0.0033
Leishmania major DNA polymerase eta, putative 0.0241 0.1157 0.1279
Echinococcus granulosus histone lysine methyltransferase setb 0.0244 0.1169 0.1322
Mycobacterium ulcerans beta-lactamase 0.0293 0.1426 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0053 0.0173 0.0195
Onchocerca volvulus Alhambra homolog 0.009 0.0365 0.0365
Leishmania major hypothetical protein, conserved 0.0029 0.0047 0.0021
Loa Loa (eye worm) glycosyl hydrolase family 2 0.0177 0.0821 0.0928
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0573 0.289 0.289
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.002 0.0002 0.0002
Brugia malayi MH1 domain containing protein 0.0068 0.0252 0.0285
Loa Loa (eye worm) hypothetical protein 0.0293 0.1426 0.1612
Trypanosoma brucei C-8 sterol isomerase, putative 0.0445 0.222 0.2486
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.0022 0.0024
Echinococcus granulosus regulator of G protein signaling 7 0.0028 0.0042 0.0047
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0287 0.0293
Brugia malayi PHD-finger family protein 0.0029 0.0049 0.0056
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0068 0.0251 0.0252
Echinococcus granulosus beta LACTamase domain containing family member 0.0293 0.1426 0.1612
Toxoplasma gondii isocitrate dehydrogenase 0.0068 0.0251 0.0252
Trichomonas vaginalis importin beta-1, putative 0.0047 0.014 0.014
Loa Loa (eye worm) RNA binding protein 0.0071 0.0267 0.0302
Echinococcus multilocularis segment polarity protein dishevelled 0.0028 0.0042 0.0047
Echinococcus granulosus Smad4 0.0068 0.0252 0.0285
Toxoplasma gondii HEAT repeat-containing protein 0.0058 0.0197 0.019
Schistosoma mansoni hypothetical protein 0.1264 0.6503 0.7354
Brugia malayi jmjC domain containing protein 0.0109 0.0464 0.0524
Schistosoma mansoni hypothetical protein 0.1264 0.6503 0.7354
Echinococcus multilocularis dna polymerase kappa 0.0241 0.1157 0.1308
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0071 0.0267 0.0302
Schistosoma mansoni z-protein (S1r protein) 0.0028 0.0042 0.0047
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0049 0.0023
Echinococcus multilocularis PHD finger protein rhinoceros 0.009 0.0365 0.0413
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0087 0.0351 0.5
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0068 0.0252 0.0285
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.002 0.0002 0.0002
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0068 0.0251 0.0284
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0387 0.0437
Schistosoma mansoni smad1 5 8 and 0.0068 0.0252 0.0285
Echinococcus multilocularis tar DNA binding protein 0.0071 0.0267 0.0302
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0042 0.0117 0.01
Echinococcus granulosus PHD finger protein rhinoceros 0.009 0.0365 0.0413
Mycobacterium tuberculosis Probable hydrolase 0.0293 0.1426 0.13
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0042 0.0117 0.0133
Onchocerca volvulus 0.1074 0.5509 0.5509
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0241 0.1157 0.1157
Echinococcus multilocularis hexokinase type 2 0.1712 0.8844 1
Schistosoma mansoni dep domain containing protein 0.0028 0.0042 0.0047
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.003 0.0053 0.0027
Loa Loa (eye worm) hypothetical protein 0.0293 0.1426 0.1612
Brugia malayi PHD-finger family protein 0.009 0.0365 0.0413
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0244 0.1169 0.1322
Trichomonas vaginalis beta-galactosidase, putative 0.0504 0.2529 0.2529
Trypanosoma brucei hexokinase 0.1712 0.8844 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.002 0.0002 0.0002
Echinococcus multilocularis hexokinase 0.1712 0.8844 1
Schistosoma mansoni jumonji domain containing protein 0.0234 0.1117 0.1263
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0068 0.0251 0.0284
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.003 0.0053 0.0027
Plasmodium vivax JmjC domain containing protein 0.0029 0.0047 0.0021
Schistosoma mansoni hypothetical protein 0.0277 0.1344 0.152
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0241 0.1157 0.1308
Echinococcus granulosus lysine specific demethylase 6a 0.0029 0.0047 0.0054
Echinococcus multilocularis JmjC domain containing protein 4 0.0029 0.0047 0.0054
Leishmania major DNA polymerase eta, putative 0.0075 0.0287 0.0293
Mycobacterium ulcerans DNA polymerase IV 0.0241 0.1157 0.7639
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0075 0.0287 0.0293
Brugia malayi Importin beta-1 subunit 0.0058 0.0197 0.0222
Loa Loa (eye worm) hexokinase 0.053 0.2665 0.3013
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.014 0.014
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.01 0.0113
Brugia malayi Hexokinase family protein 0.1712 0.8844 1
Brugia malayi Cyclic-nucleotide gated cation channel 0.002 0.0002 0.0002
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0293 0.1426 0.1612
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.0022 0.0024
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0029 0.0047 0.0054
Trypanosoma brucei DNA polymerase kappa, putative 0.0075 0.0287 0.0293
Brugia malayi hypothetical protein 0.0028 0.0042 0.0047
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0299 0.146 0.1651
Schistosoma mansoni hypothetical protein 0.0614 0.3106 0.3512
Echinococcus granulosus dna polymerase eta 0.0241 0.1157 0.1308
Onchocerca volvulus 0.0293 0.1426 0.1426
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0293 0.1426 0.13
Trypanosoma brucei DNA polymerase kappa, putative 0.0166 0.0765 0.0835
Brugia malayi Beta-glucuronidase precursor 0.0163 0.075 0.0848
Mycobacterium ulcerans lipase LipD 0.0293 0.1426 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0081 0.0318 0.0359
Schistosoma mansoni Smad4 0.003 0.0055 0.0062
Trichomonas vaginalis D-aminoacylase, putative 0.0293 0.1426 0.1426
Brugia malayi Hexokinase family protein 0.053 0.2665 0.3013
Schistosoma mansoni voltage-gated potassium channel 0.0057 0.0192 0.0217
Loa Loa (eye worm) MH2 domain-containing protein 0.0999 0.512 0.579
Trypanosoma brucei importin beta-1 subunit, putative 0.0058 0.0197 0.019
Trypanosoma cruzi hexokinase, putative 0.1712 0.8844 1
Loa Loa (eye worm) acetyltransferase 0.0299 0.146 0.1651
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0068 0.0251 0.0284
Echinococcus granulosus hyperpolarization activated cyclic 0.002 0.0002 0.0002
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0029 0.0047 0.0054
Echinococcus multilocularis importin subunit beta 1 0.0058 0.0197 0.0222
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.002 0.0002 0.0002
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0117 0.0133
Echinococcus multilocularis mothers against decapentaplegic 6 0.003 0.0055 0.0062
Loa Loa (eye worm) hypothetical protein 0.003 0.0055 0.0062
Mycobacterium tuberculosis Possible penicillin-binding protein 0.187 0.9669 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.0054
Mycobacterium tuberculosis Conserved protein 0.0293 0.1426 0.13
Loa Loa (eye worm) hypothetical protein 0.0227 0.1084 0.1226
Mycobacterium ulcerans hypothetical protein 0.0293 0.1426 1
Plasmodium falciparum hexokinase 0.1712 0.8844 1
Echinococcus granulosus voltage gated potassium channel 0.0024 0.0022 0.0024
Leishmania major DNA polymerase kappa, putative 0.0241 0.1157 0.1279
Schistosoma mansoni hypothetical protein 0.0478 0.2394 0.2706
Trypanosoma brucei DNA damage repair protein, putative 0.0075 0.0287 0.0293
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.01 0.0113
Echinococcus multilocularis isocitrate dehydrogenase 0.0068 0.0251 0.0284
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0024 0.0022 0.0024
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0117 0.0133
Loa Loa (eye worm) jmjC domain-containing protein 0.0109 0.0464 0.0524
Entamoeba histolytica hypothetical protein 0.0039 0.01 0.0113
Schistosoma mansoni ran 0.0042 0.0117 0.0133
Echinococcus granulosus cyclic nucleotide gated cation channel 0.002 0.0002 0.0002
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0267 0.0302
Schistosoma mansoni phosphatidylserine receptor 0.0029 0.0047 0.0054
Schistosoma mansoni hypothetical protein 0.009 0.0365 0.0413
Echinococcus multilocularis phd:f box containing protein 0.0029 0.0047 0.0054
Giardia lamblia DNA damage repair protein 0.0075 0.0287 0.1635
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0241 0.1157 0.1308
Echinococcus multilocularis voltage gated potassium channel 0.0024 0.0022 0.0024
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.002 0.0002 0.0002
Echinococcus multilocularis segment polarity protein dishevelled 0.0028 0.0042 0.0047
Loa Loa (eye worm) hypothetical protein 0.0544 0.2741 0.3099
Trypanosoma cruzi DNA polymerase eta, putative 0.0075 0.0287 0.0325
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0267 0.0302
Brugia malayi hypothetical protein 0.0028 0.0042 0.0047
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0029 0.0047 0.0054
Trypanosoma cruzi DNA polymerase kappa, putative 0.0241 0.1157 0.1308
Loa Loa (eye worm) hypothetical protein 0.0293 0.1426 0.1612
Echinococcus granulosus jumonji domain containing 1A 0.0029 0.0047 0.0054
Echinococcus granulosus histone acetyltransferase KAT2B 0.0291 0.1416 0.1601
Echinococcus granulosus segment polarity protein dishevelled 0.0028 0.0042 0.0047
Schistosoma mansoni phd/f-box containing protein 0.0029 0.0047 0.0054
Loa Loa (eye worm) hypothetical protein 0.009 0.0365 0.0413
Schistosoma mansoni voltage-gated potassium channel 0.0057 0.0192 0.0217
Onchocerca volvulus 0.1712 0.8844 0.8844
Echinococcus granulosus regulator of G protein signaling 7 0.0028 0.0042 0.0047
Echinococcus multilocularis hyperpolarization activated cyclic 0.002 0.0002 0.0002
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0293 0.1426 0.13
Entamoeba histolytica hypothetical protein 0.0039 0.01 0.0113
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0029 0.0047 0.0021
Echinococcus granulosus GTP binding nuclear protein Ran 0.0042 0.0117 0.0133
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.0054
Trypanosoma cruzi DNA polymerase kappa, putative 0.0241 0.1157 0.1308
Trypanosoma brucei hexokinase, putative 0.1712 0.8844 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0166 0.0765 0.0835
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0075 0.0287 0.0293
Loa Loa (eye worm) beta-lactamase 0.0293 0.1426 0.1612
Mycobacterium tuberculosis Conserved protein 0.0293 0.1426 0.13
Toxoplasma gondii isocitrate dehydrogenase 0.0068 0.0251 0.0252
Echinococcus multilocularis jumonji domain containing 1A 0.0029 0.0047 0.0054
Leishmania major DNA polymerase kappa, putative 0.0075 0.0287 0.0293
Toxoplasma gondii hypothetical protein 0.003 0.0053 0.0027
Loa Loa (eye worm) hypothetical protein 0.0087 0.0351 0.0397
Brugia malayi Pre-SET motif family protein 0.0244 0.1169 0.1322
Echinococcus granulosus mothers against decapentaplegic 2 0.003 0.0055 0.0062
Schistosoma mansoni jumonji/arid domain-containing protein 0.0109 0.0464 0.0524
Trichomonas vaginalis ran, putative 0.0042 0.0117 0.0117
Trypanosoma brucei DNA polymerase IV, putative 0.0241 0.1157 0.1279
Echinococcus granulosus hexokinase 0.1712 0.8844 1
Brugia malayi RNA recognition motif domain containing protein 0.0071 0.0267 0.0302
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0042 0.0117 0.01
Brugia malayi RNA binding protein 0.0071 0.0267 0.0302
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0277 0.1344 0.152
Echinococcus granulosus lysine specific demethylase 5A 0.0109 0.0464 0.0524
Mycobacterium tuberculosis Conserved hypothetical protein 0.0241 0.1157 0.1016
Trypanosoma brucei DNA polymerase kappa, putative 0.0241 0.1157 0.1279
Trypanosoma brucei DNA polymerase kappa, putative 0.0241 0.1157 0.1279
Trypanosoma cruzi DNA polymerase kappa, putative 0.0241 0.1157 0.1308
Echinococcus multilocularis lysine specific demethylase 6a 0.0029 0.0047 0.0054
Schistosoma mansoni hypothetical protein 0.0029 0.0049 0.0056
Trypanosoma brucei importin beta-1 subunit, putative 0.0058 0.0197 0.019
Trypanosoma brucei DNA polymerase kappa, putative 0.0241 0.1157 0.1279
Trichomonas vaginalis conserved hypothetical protein 0.0504 0.2529 0.2529
Leishmania major hypothetical protein, conserved 0.0293 0.1426 0.1584
Mycobacterium tuberculosis Probable lipase LipE 0.0293 0.1426 0.13
Brugia malayi Pre-SET motif family protein 0.1698 0.8774 0.9921
Echinococcus granulosus geminin 0.1264 0.6503 0.7354
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0387 0.0437
Mycobacterium leprae conserved hypothetical protein 0.0293 0.1426 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0299 0.146 0.1651
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0068 0.0251 0.0284
Echinococcus multilocularis Smad4 0.0068 0.0252 0.0285
Brugia malayi Probable ClpP-like protease 0.0087 0.0351 0.0397
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0087 0.0351 0.0365
Trypanosoma brucei DNA damage repair protein, putative 0.0075 0.0287 0.0293
Entamoeba histolytica hexokinase 1 0.1712 0.8844 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0068 0.0252 0.0285
Onchocerca volvulus 0.0293 0.1426 0.1426
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0293 0.1426 0.13
Schistosoma mansoni hexokinase 0.1712 0.8844 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0042 0.0117 0.01
Plasmodium vivax DNA repair protein REV1, putative 0.0075 0.0287 0.0293
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0875 0.4472 0.5057
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0029 0.0049 0.0023
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0024
Schistosoma mansoni dishevelled 0.0028 0.0042 0.0047
Plasmodium vivax hexokinase, putative 0.1712 0.8844 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0053 0.0173 0.0195
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.002 0.0002 0.0002
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0277 0.1344 0.152
Toxoplasma gondii PHD-finger domain-containing protein 0.009 0.0365 0.0381
Loa Loa (eye worm) hypothetical protein 0.1167 0.5999 0.6783
Loa Loa (eye worm) hypothetical protein 0.0058 0.0197 0.0222
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1641 0.8472 0.958
Brugia malayi MH1 domain containing protein 0.0038 0.0093 0.0105
Loa Loa (eye worm) hypothetical protein 0.0293 0.1426 0.1612
Echinococcus multilocularis regulator of G protein signaling 7 0.0028 0.0042 0.0047
Brugia malayi Smad1 0.0068 0.0252 0.0285
Giardia lamblia PHD finger protein 15 0.009 0.0365 0.2384
Echinococcus multilocularis mothers against decapentaplegic 2 0.003 0.0055 0.0062
Echinococcus multilocularis regulator of G protein signaling 7 0.0028 0.0042 0.0047
Trypanosoma brucei DNA polymerase eta, putative 0.0241 0.1157 0.1279
Echinococcus multilocularis GPCR, family 2 0.0277 0.1344 0.152
Loa Loa (eye worm) hypothetical protein 0.0028 0.0042 0.0047
Trypanosoma brucei unspecified product 0.0241 0.1157 0.1279
Trypanosoma cruzi importin beta-1 subunit, putative 0.0047 0.014 0.0158
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0029 0.0047 0.0054
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0088 0.0356 0.0356
Trichomonas vaginalis DNA polymerase eta, putative 0.0241 0.1157 0.1157
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0029 0.0047 0.0021
Echinococcus granulosus phd:f box containing protein 0.0029 0.0047 0.0054
Schistosoma mansoni hypothetical protein 0.0277 0.1344 0.152
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0057 0.0194 0.103
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.0387 0.0437
Trypanosoma brucei DNA polymerase kappa, putative 0.0241 0.1157 0.1279
Echinococcus granulosus dna polymerase kappa 0.0241 0.1157 0.1308
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0042 0.0117 0.01
Brugia malayi hypothetical protein 0.0025 0.0029 0.0033
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.002 0.0002 0.0002
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0028 0.0042 0.0047
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0049 0.0023
Echinococcus granulosus snurportin 1 0.0614 0.3106 0.3512
Loa Loa (eye worm) hypothetical protein 0.0028 0.0042 0.0047
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0028 0.0042 0.0047
Echinococcus granulosus hexokinase 0.1712 0.8844 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.002 0.0002 0.0002
Entamoeba histolytica hypothetical protein 0.0047 0.014 0.0158
Brugia malayi MH2 domain containing protein 0.0068 0.0252 0.0285
Toxoplasma gondii PHD-finger domain-containing protein 0.009 0.0365 0.0381
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0042 0.0117 0.0133
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0028 0.0042 0.0047
Brugia malayi N-terminal motif family protein 0.0573 0.289 0.3268
Loa Loa (eye worm) nuclear factor I 0.0038 0.0093 0.0105
Trypanosoma brucei hexokinase 0.1712 0.8844 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0241 0.1157 0.1308
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0024 0.0023 0.0026
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0024 0.0022 0.0024
Schistosoma mansoni smad 0.0068 0.0252 0.0285
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0087 0.0351 0.0365
Trichomonas vaginalis glycoside hydrolase, putative 0.0804 0.4101 0.4101
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0068 0.0251 0.0252
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0068 0.0251 0.006
Brugia malayi TAR-binding protein 0.0071 0.0267 0.0302
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0053 0.0173 0.0195
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0387 0.0437
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0068 0.0251 0.0252
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0277 0.1344 0.152
Brugia malayi MH2 domain containing protein 0.003 0.0055 0.0062
Echinococcus granulosus GPCR family 2 0.0277 0.1344 0.152
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0267 0.0302
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.0387 0.0437
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0293 0.1426 0.1612
Trypanosoma cruzi DNA damage repair protein, putative 0.0075 0.0287 0.0325
Loa Loa (eye worm) isocitrate dehydrogenase 0.0068 0.0251 0.0284
Brugia malayi Bromodomain containing protein 0.0097 0.0403 0.0456
Brugia malayi Calcitonin receptor-like protein seb-1 0.0875 0.4472 0.5057
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.01 0.0113
Onchocerca volvulus 0.0293 0.1426 0.1426
Mycobacterium ulcerans esterase/lipase LipP 0.0293 0.1426 1
Echinococcus multilocularis peregrin 0.0097 0.0403 0.0456
Brugia malayi isocitrate dehydrogenase 0.0068 0.0251 0.0284
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0244 0.1169 0.1322
Loa Loa (eye worm) hypothetical protein 0.002 0.0002 0.0002
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0087 0.0351 0.5
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0068 0.0252 0.0285
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0241 0.1157 0.1016
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0029 0.0049 0.0023
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0087 0.0351 0.0397
Trypanosoma brucei DNA polymerase kappa, putative 0.0241 0.1157 0.1279
Mycobacterium ulcerans DNA polymerase IV 0.0241 0.1157 0.7639
Echinococcus granulosus hexokinase type 2 0.1712 0.8844 1
Onchocerca volvulus Mothers against decapentaplegic homolog 0.003 0.0055 0.0055
Onchocerca volvulus 0.1712 0.8844 0.8844
Trypanosoma cruzi DNA polymerase kappa, putative 0.0241 0.1157 0.1308
Trichomonas vaginalis D-aminoacylase, putative 0.0293 0.1426 0.1426
Echinococcus granulosus mothers against decapentaplegic 5 0.0068 0.0252 0.0285
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0244 0.1169 0.1322
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0068 0.0251 0.0284
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0614 0.3106 0.3512
Brugia malayi manba-prov protein 0.0163 0.075 0.0848
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.002 0.0002 0.0002
Plasmodium falciparum histone acetyltransferase GCN5 0.0081 0.0318 0.0327
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.002 0.0002 0.0002
Giardia lamblia Histone acetyltransferase GCN5 0.0081 0.0318 0.1927
Echinococcus multilocularis snurportin 1 0.0614 0.3106 0.3512
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0068 0.0251 0.0284
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0287 0.0293
Trypanosoma cruzi DNA polymerase eta, putative 0.0241 0.1157 0.1308
Onchocerca volvulus Hexokinase homolog 0.1074 0.5509 0.5509
Entamoeba histolytica deoxycytidyl transferase, putative 0.0241 0.1157 0.1308
Loa Loa (eye worm) hexokinase 0.1712 0.8844 1
Schistosoma mansoni dishevelled 0.0028 0.0042 0.0047
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0075 0.0287 0.0293
Trichomonas vaginalis beta-mannosidase, putative 0.0163 0.075 0.075
Leishmania major importin beta-1 subunit, putative 0.0047 0.014 0.0126
Loa Loa (eye worm) hypothetical protein 0.0598 0.3024 0.342
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0087 0.0351 0.0559
Loa Loa (eye worm) hypothetical protein 0.0028 0.0042 0.0047
Trichomonas vaginalis penicillin-binding protein, putative 0.0293 0.1426 0.1426
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.002 0.0002 0.0002
Echinococcus granulosus smad 0.0068 0.0252 0.0285
Loa Loa (eye worm) hexokinase 0.1712 0.8844 1
Mycobacterium tuberculosis Probable lipase LipD 0.0293 0.1426 0.13
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0068 0.0251 0.0284
Loa Loa (eye worm) hypothetical protein 0.0244 0.1169 0.1322
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0244 0.1169 0.1294
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0029 0.0033
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0047 0.0054
Echinococcus granulosus tar DNA binding protein 0.0071 0.0267 0.0302
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0038 0.0096 0.0109
Brugia malayi ImpB/MucB/SamB family protein 0.0241 0.1157 0.1308
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0267 0.0302
Loa Loa (eye worm) latrophilin receptor protein 2 0.0277 0.1344 0.152
Entamoeba histolytica beta-galactosidase, putative 0.034 0.1675 0.1894
Mycobacterium tuberculosis Probable esterase LipL 0.0293 0.1426 0.13
Plasmodium vivax importin-beta 2, putative 0.0058 0.0197 0.019
Echinococcus multilocularis lysine specific demethylase 5A 0.0109 0.0464 0.0524
Loa Loa (eye worm) hexokinase 0.1074 0.5509 0.623
Loa Loa (eye worm) PHD-finger family protein 0.009 0.0365 0.0413
Schistosoma mansoni jumonji/arid domain-containing protein 0.0109 0.0464 0.0524
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0087 0.0351 0.0397
Schistosoma mansoni peptidase Clp (S14 family) 0.0087 0.0351 0.0397
Brugia malayi MH2 domain containing protein 0.0999 0.512 0.579
Echinococcus granulosus mothers against decapentaplegic 6 0.003 0.0055 0.0062
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.002 0.0002 0.0002
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0047 0.0054
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0029 0.0033
Loa Loa (eye worm) MH2 domain-containing protein 0.003 0.0055 0.0062
Brugia malayi latrophilin 2 splice variant baaae 0.0598 0.3024 0.342
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0053 0.0173 0.0195
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0277 0.1344 0.152
Loa Loa (eye worm) hypothetical protein 0.0293 0.1426 0.1612
Loa Loa (eye worm) MH1 domain-containing protein 0.0068 0.0252 0.0285
Schistosoma mansoni smad 0.003 0.0055 0.0062
Plasmodium falciparum phd finger protein, putative 0.009 0.0365 0.0381
Echinococcus granulosus TGF beta signal transducer SmadC 0.0068 0.0252 0.0285
Entamoeba histolytica hypothetical protein 0.0039 0.01 0.0113
Schistosoma mansoni hypothetical protein 0.0277 0.1344 0.152
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0235 0.1122 0.1269
Onchocerca volvulus 0.0028 0.0042 0.0042
Brugia malayi ImpB/MucB/SamB family protein 0.0241 0.1157 0.1308
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0387 0.0437
Trypanosoma brucei chrX additional, unordered contigs 0.0075 0.0287 0.0293
Brugia malayi AF-10 protein 0.0029 0.0049 0.0056
Schistosoma mansoni importin beta-1 0.0058 0.0197 0.0222
Loa Loa (eye worm) hypothetical protein 0.0154 0.07 0.0792
Schistosoma mansoni hypothetical protein 0.0598 0.3024 0.342
Trypanosoma cruzi DNA damage repair protein, putative 0.0075 0.0287 0.0325
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0029 0.0049 0.0023
Schistosoma mansoni jumonji domain containing protein 0.0029 0.0047 0.0054
Brugia malayi beta-lactamase family protein 0.0293 0.1426 0.1612
Loa Loa (eye worm) hypothetical protein 0.0038 0.0093 0.0105
Loa Loa (eye worm) hypothetical protein 0.0277 0.1344 0.152
Leishmania major hexokinase, putative 0.1712 0.8844 1
Echinococcus multilocularis geminin 0.1264 0.6503 0.7354
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0029 0.0047 0.0021
Loa Loa (eye worm) MH2 domain-containing protein 0.0068 0.0252 0.0285
Loa Loa (eye worm) hypothetical protein 0.0075 0.0287 0.0325
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.005 0.0159 0.0159
Schistosoma mansoni smad1 5 8 and 0.0068 0.0252 0.0285
Echinococcus granulosus peregrin 0.0097 0.0403 0.0456
Toxoplasma gondii hypothetical protein 0.0028 0.0042 0.0015
Echinococcus granulosus hexokinase 0.1712 0.8844 1
Brugia malayi Isocitrate dehydrogenase 0.0068 0.0251 0.0284
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0087 0.0351 0.0365
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0244 0.1169 0.1322
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0088 0.0356 0.0371
Trypanosoma brucei unspecified product 0.0166 0.0765 0.0835

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 16 nM Binding affinity for sigma receptor in guinea pig brain membrane using radiolabeled ligand [3H]-(+)-SKF- 10,047 was determined ChEMBL. No reference
Ki (binding) > 10000 nM Binding affinity for dopamine receptor D2 in guinea pig striatal membrane using radiolabeled ligand [3H]-spiperone ChEMBL. No reference
Ki (binding) = 100000 nM Binding affinity of the compound towards PCP receptor in guinea pig brain membrane using radiolabeled ligand [3H]-TCP (1-[1-(2-thienyl)cyclohexyl]piperidine) was determined ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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