Detailed information for compound 1037313

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 293.588 | Formula: C10H14BrClN2O
  • H donors: 1 H acceptors: 1 LogP: 2.26 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNC1(CC1)COc1cncc(c1)Br.Cl
  • InChi: 1S/C10H13BrN2O.ClH/c1-12-10(2-3-10)7-14-9-4-8(11)5-13-6-9;/h4-6,12H,2-3,7H2,1H3;1H
  • InChiKey: ANRIPGHNXBDSAO-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Starlite/ChEMBL References
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130932 All targets in OG5_130932
Schistosoma japonicum Neuronal acetylcholine receptor subunit alpha-7 precursor, putative Get druggable targets OG5_130932 All targets in OG5_130932
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) Get druggable targets OG5_130932 All targets in OG5_130932
Onchocerca volvulus Get druggable targets OG5_130932 All targets in OG5_130932
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130932 All targets in OG5_130932
Onchocerca volvulus Get druggable targets OG5_130932 All targets in OG5_130932
Brugia malayi Cation transporter family protein Get druggable targets OG5_130932 All targets in OG5_130932
Schistosoma japonicum IPR006201,Neurotransmitter-gated ion-channel;IPR006029,Neurotransmitter-gated ion-channel transmembrane region,domain-containing Get druggable targets OG5_130932 All targets in OG5_130932
Schistosoma japonicum ko:K04809 cholinergic receptor, nicotinic, alpha 7, putative Get druggable targets OG5_130932 All targets in OG5_130932
Schistosoma japonicum Neuronal acetylcholine receptor subunit alpha-7 precursor, putative Get druggable targets OG5_130932 All targets in OG5_130932
Onchocerca volvulus Get druggable targets OG5_130932 All targets in OG5_130932
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130932 All targets in OG5_130932
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) Get druggable targets OG5_130932 All targets in OG5_130932
Schistosoma japonicum Neuronal acetylcholine receptor subunit alpha-7 precursor, putative Get druggable targets OG5_130932 All targets in OG5_130932

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Putative zinc finger protein Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 515 aa 36.9 %
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 511 aa 36.0 %
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 486 aa 33.1 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 501 aa 36.5 %
Onchocerca volvulus Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 552 aa 24.3 %
Loa Loa (eye worm) hypothetical protein Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 491 aa 36.0 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 513 aa 35.5 %
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 484 aa 34.3 %
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 501 aa 32.1 %
Onchocerca volvulus Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 496 aa 35.5 %
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 485 aa 32.6 %
Onchocerca volvulus Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 482 aa 42.9 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type des-2 homolog Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 530 aa 29.6 %
Schistosoma japonicum Neuronal acetylcholine receptor subunit alpha-3 precursor, putative Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 518 aa 24.9 %
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 486 aa 32.9 %
Schistosoma mansoni nAChR subunit Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 543 aa 27.8 %
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 519 aa 25.6 %
Onchocerca volvulus 39S ribosomal protein L13, mitochondrial homolog Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 475 aa 36.8 %
Loa Loa (eye worm) acetylcholine receptor alpha subunit Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 507 aa 35.3 %
Echinococcus multilocularis nAChR subunit Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 488 aa 27.9 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 513 aa 35.5 %
Brugia malayi acetylcholine receptor alpha subunit precursor, putative Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 497 aa 35.0 %
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 510 aa 36.1 %
Drosophila melanogaster nicotinic Acetylcholine Receptor alpha2 Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 508 aa 38.6 %
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 527 aa 33.6 %
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 511 aa 27.2 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Mycobacterium ulcerans bacterioferritin BfrA 0.0052 0.0171 0.066
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0038 0.0084 0.0186
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0038 0.0084 0.0084
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0092 0.0401 0.0401
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.007 0.008
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0006 0.0069
Echinococcus granulosus chromobox protein 1 0.0071 0.028 0.028
Trichomonas vaginalis set domain proteins, putative 0.0721 0.41 0.778
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0919 0.5261 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0449 0.25 1
Echinococcus granulosus pyruvate kinase 0.0093 0.0409 0.0409
Echinococcus multilocularis phd:f box containing protein 0.0054 0.018 0.018
Echinococcus multilocularis expressed protein 0.0052 0.0171 0.0171
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0836 0.1543
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0092 0.0401 0.2352
Brugia malayi excitatory GABA receptor EXP-1A 0.0038 0.0084 0.0186
Mycobacterium tuberculosis Conserved protein 0.0038 0.0088 0.0327
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.007 0.008
Brugia malayi Bromodomain containing protein 0.012 0.0567 0.1253
Brugia malayi hypothetical protein 0.0025 0.001 0.0023
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0149 0.0329
Onchocerca volvulus Glucosylceramidase homolog 0.0166 0.0836 0.2039
Loa Loa (eye worm) LGC-31 protein 0.0038 0.0084 0.0084
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0054 0.018 0.018
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0016 0.0057
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.072 0.4279
Brugia malayi Peptidase family M1 containing protein 0.0092 0.0401 0.0887
Leishmania major hypothetical protein, conserved 0.0025 0.001 0.0023
Loa Loa (eye worm) TATA binding protein associated factor 0.0092 0.0401 0.0401
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0016 0.0038
Echinococcus multilocularis JmjC domain containing protein 4 0.0054 0.018 0.018
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0888 0.1643
Schistosoma mansoni cpg binding protein 0.003 0.0037 0.0037
Loa Loa (eye worm) ACC-1 protein 0.0038 0.0084 0.0084
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0103 0.0468 0.0468
Schistosoma mansoni lipoxygenase 0.014 0.0684 0.0684
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0092 0.0401 0.0401
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0252 0.1346 0.2976
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0016 0.0035
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0092 0.0401 0.237
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0039 0.0093 0.0519
Onchocerca volvulus 0.0038 0.0084 0.0205
Loa Loa (eye worm) jmjC domain-containing protein 0.0054 0.018 0.018
Entamoeba histolytica pyruvate kinase, putative 0.0126 0.0606 0.114
Loa Loa (eye worm) hypothetical protein 0.012 0.0566 0.0566
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0919 0.5261 1
Echinococcus granulosus ferritin 0.0052 0.0171 0.0171
Trypanosoma cruzi Aminopeptidase M1, putative 0.0092 0.0401 0.2352
Loa Loa (eye worm) hypothetical protein 0.0038 0.0084 0.0084
Leishmania major hypothetical protein, conserved 0.0054 0.018 0.1042
Loa Loa (eye worm) hypothetical protein 0.0038 0.0084 0.0084
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0038 0.0084 0.0084
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0016 0.0038
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.007 0.007
Brugia malayi PHD-finger family protein 0.012 0.0567 0.1253
Echinococcus multilocularis survival motor neuron protein 1 0.0247 0.1315 0.1315
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.014 0.0684 0.0684
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.0799 0.0799
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0117 0.0644
Loa Loa (eye worm) hypothetical protein 0.031 0.1686 0.1686
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0038 0.0084 0.0186
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0159 0.0799 0.0799
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0092 0.0401 0.0401
Loa Loa (eye worm) hypothetical protein 0.0041 0.0102 0.0102
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0092 0.0401 0.0712
Echinococcus granulosus pyruvate kinase 0.0093 0.0409 0.0409
Entamoeba histolytica hypothetical protein 0.0071 0.028 0.0521
Leishmania major pyruvate kinase 0.0181 0.0928 0.5528
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0016 0.0038
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0092 0.0401 0.0401
Onchocerca volvulus 0.0038 0.0088 0.0215
Onchocerca volvulus 0.0092 0.0401 0.0979
Onchocerca volvulus 0.0721 0.41 1
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0088 0.0327
Brugia malayi Cytochrome P450 family protein 0.0058 0.0202 0.0447
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0052 0.0171 0.066
Echinococcus multilocularis aminopeptidase N 0.0092 0.0401 0.0401
Brugia malayi F/Y-rich N-terminus family protein 0.0051 0.0163 0.036
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.007 0.008
Echinococcus granulosus chromobox protein 1 0.0071 0.028 0.028
Onchocerca volvulus 0.0038 0.0084 0.0205
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0092 0.0401 0.4326
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0099 0.0447 0.0447
Onchocerca volvulus 0.0038 0.0088 0.0215
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.031 0.1686 0.3728
Loa Loa (eye worm) hypothetical protein 0.0087 0.0373 0.0373
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0098 0.044 0.044
Onchocerca volvulus Huntingtin homolog 0.012 0.0566 0.1382
Onchocerca volvulus Putative nachr subunit 0.0038 0.0084 0.0205
Echinococcus multilocularis jun protein 0.0099 0.0447 0.0447
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0088 0.0114
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0084 0.0186
Echinococcus multilocularis leukotriene A 4 hydrolase 0.1725 1 1
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0092 0.0401 0.4326
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0038 0.0084 0.0084
Mycobacterium ulcerans pyruvate kinase 0.0181 0.0928 0.3695
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0149 0.0149
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0052 0.0171 0.066
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0117 0.0644
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0041 0.0103 0.1109
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0038 0.0084 0.0084
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0038 0.0084 0.0084
Schistosoma mansoni ferritin light chain 0.0052 0.0171 0.0171
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0038 0.0084 0.0186
Mycobacterium ulcerans lipase LipD 0.0038 0.0088 0.0327
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0449 0.25 1
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.001 0.0041
Loa Loa (eye worm) hypothetical protein 0.0038 0.0088 0.0088
Trichomonas vaginalis esterase, putative 0.0038 0.0088 0.0114
Loa Loa (eye worm) hypothetical protein 0.0038 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0092 0.0401 0.0401
Brugia malayi beta-lactamase 0.0038 0.0088 0.0194
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0092 0.0401 0.4326
Loa Loa (eye worm) hypothetical protein 0.0038 0.0084 0.0084
Entamoeba histolytica hypothetical protein 0.0071 0.028 0.0521
Brugia malayi jmjC domain containing protein 0.0054 0.018 0.0398
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0016 0.0038
Loa Loa (eye worm) pyruvate kinase 0.0181 0.0928 0.0928
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0038 0.0084 0.0084
Schistosoma mansoni protein phosphatase 2C 0.0054 0.018 0.018
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0038 0.0084 0.0084
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0054 0.018 0.1022
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0181 0.0928 0.3695
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0099 0.0447 0.0447
Echinococcus multilocularis pyruvate kinase 0.0143 0.0703 0.0703
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0088 0.0114
Echinococcus multilocularis nAChR subunit 0.0038 0.0084 0.0084
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.072 0.4266
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0919 0.5261 1
Brugia malayi Peptidase family M1 containing protein 0.0092 0.0401 0.0887
Schistosoma mansoni alpha-glucosidase 0.0137 0.0668 0.0668
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0016 0.0038
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0092 0.0401 0.237
Echinococcus granulosus glycine receptor subunit alpha 1 0.0038 0.0084 0.0084
Onchocerca volvulus 0.0078 0.0322 0.0785
Echinococcus multilocularis L aminoadipate semialdehyde 0.0087 0.0373 0.0373
Mycobacterium leprae Probable lipase LipE 0.0038 0.0088 0.0327
Schistosoma mansoni apoferritin-2 0.0052 0.0171 0.0171
Mycobacterium ulcerans hypothetical protein 0.0162 0.0816 0.3248
Loa Loa (eye worm) hypothetical protein 0.012 0.0567 0.0567
Plasmodium falciparum pyruvate kinase 2 0.0093 0.0409 0.4413
Brugia malayi pyruvate kinase 0.0038 0.0087 0.0193
Plasmodium vivax JmjC domain containing protein 0.0054 0.018 0.1941
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0084 0.0186
Plasmodium vivax SET domain protein, putative 0.0091 0.04 0.431
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0088 0.0194
Mycobacterium tuberculosis Conserved protein 0.0038 0.0088 0.0327
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0054 0.018 0.1885
Loa Loa (eye worm) hypothetical protein 0.0221 0.116 0.116
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0038 0.0084 0.0186
Brugia malayi hypothetical protein 0.0071 0.028 0.0619
Loa Loa (eye worm) hypothetical protein 0.0038 0.0084 0.0084
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.1725 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0888 0.1643
Toxoplasma gondii aminopeptidase N, putative 0.0092 0.0401 0.4287
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.001 0.0023
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0016 0.0057
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.007 0.008
Echinococcus multilocularis PHD finger protein rhinoceros 0.012 0.0567 0.0567
Echinococcus granulosus histone lysine methyltransferase setb 0.0091 0.04 0.04
Schistosoma mansoni hypothetical protein 0.0098 0.044 0.044
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0092 0.0401 0.4326
Trypanosoma brucei pyruvate kinase 1 0.0181 0.0928 0.5528
Echinococcus granulosus glycine receptor subunit beta 0.0038 0.0084 0.0084
Schistosoma mansoni survival motor neuron protein 0.005 0.0159 0.0159
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0038 0.0084 0.0186
Schistosoma mansoni nAChR subunit 0.0038 0.0084 0.0084
Schistosoma mansoni hypothetical protein 0.0039 0.0093 0.0093
Toxoplasma gondii hypothetical protein 0.005 0.0155 0.1611
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0173 0.0979
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0091 0.04 0.04
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0098 0.044 0.044
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0088 0.0327
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0088 0.0088
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.001 0.011
Toxoplasma gondii pyruvate kinase PyKII 0.0093 0.0409 0.4374
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0016 0.0035
Schistosoma mansoni ferritin 0.0052 0.0171 0.0171
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0038 0.0084 0.0084
Giardia lamblia Fructose-bisphosphate aldolase 0.0919 0.5261 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.028 0.028
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0117 0.0644
Echinococcus granulosus aminopeptidase N 0.0092 0.0401 0.0401
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0092 0.0401 0.0401
Loa Loa (eye worm) latrophilin receptor protein 2 0.0098 0.044 0.044
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0088 0.0948
Loa Loa (eye worm) pyruvate kinase-PB 0.0126 0.0606 0.0606
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0088 0.0327
Echinococcus granulosus pyruvate kinase 0.0181 0.0928 0.0928
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0092 0.0401 0.0401
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0845 0.483 0.483
Schistosoma mansoni jun-related protein 0.0081 0.0338 0.0338
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0088 0.0114
Brugia malayi Cation transporter family protein 0.0038 0.0084 0.0186
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0056 0.0189 0.0189
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0098 0.044 0.044
Onchocerca volvulus Huntingtin homolog 0.012 0.0566 0.1382
Echinococcus multilocularis ferritin 0.0052 0.0171 0.0171
Loa Loa (eye worm) ACC-1 protein 0.0038 0.0084 0.0084
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0919 0.5261 1
Trypanosoma brucei pyruvate kinase 1, putative 0.0181 0.0928 0.5528
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0092 0.0401 0.0401
Brugia malayi bZIP transcription factor family protein 0.0099 0.0447 0.0989
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0055 0.0185 0.0409
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0088 0.0327
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.028 0.028
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.007 0.008
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0088 0.0468
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0097 0.0236
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0092 0.0401 0.0401
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0098 0.044 0.0972
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0087 0.0087
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0092 0.0401 0.2352
Echinococcus multilocularis GPCR, family 2 0.0098 0.044 0.044
Echinococcus multilocularis geminin 0.0881 0.5038 0.5038
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.1346 0.2518
Trichomonas vaginalis glutaminase, putative 0.0286 0.1541 0.2891
Loa Loa (eye worm) hypothetical protein 0.0038 0.0084 0.0084
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0038 0.0084 0.0084
Brugia malayi Glycosyl hydrolases family 31 protein 0.0159 0.0799 0.1765
Loa Loa (eye worm) hypothetical protein 0.0031 0.0046 0.0046
Brugia malayi Peptidase family M1 containing protein 0.0092 0.0401 0.0887
Schistosoma mansoni hypothetical protein 0.0212 0.1109 0.1109
Toxoplasma gondii aminopeptidase N protein 0.0092 0.0401 0.4287
Trypanosoma cruzi aminopeptidase, putative 0.0092 0.0401 0.2352
Onchocerca volvulus 0.0026 0.0016 0.0039
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0038 0.0084 0.0084
Schistosoma mansoni jumonji/arid domain-containing protein 0.0204 0.1062 0.1062
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0919 0.5261 1
Echinococcus granulosus jun protein 0.0099 0.0447 0.0447
Entamoeba histolytica hypothetical protein 0.0071 0.028 0.0521
Onchocerca volvulus 0.0123 0.0586 0.143
Schistosoma mansoni nAChR subunit 0.0038 0.0084 0.0084
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.007 0.0156
Loa Loa (eye worm) hypothetical protein 0.0092 0.0401 0.0401
Loa Loa (eye worm) beta-lactamase 0.0038 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0038 0.0084 0.0084
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0115 0.028
Giardia lamblia Pyruvate kinase 0.0181 0.0928 0.1068
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0016 0.0038
Brugia malayi Pre-SET motif family protein 0.0091 0.04 0.0884
Schistosoma mansoni chromobox protein 0.0071 0.028 0.028
Mycobacterium tuberculosis Conserved hypothetical protein 0.0162 0.0816 0.3248
Plasmodium falciparum JmjC domain-containing protein, putative 0.0054 0.018 0.1941
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0123 0.0586 0.0586
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0088 0.0327
Onchocerca volvulus 0.0028 0.0028 0.0068
Loa Loa (eye worm) hypothetical protein 0.0098 0.044 0.044
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0092 0.0401 0.0401
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0088 0.0489
Schistosoma mansoni nAChR subunit 0.0038 0.0084 0.0084
Brugia malayi Pre-SET motif family protein 0.0634 0.3586 0.7927
Loa Loa (eye worm) hypothetical protein 0.0038 0.0084 0.0084
Schistosoma mansoni ferritin light chain 0.0052 0.0171 0.0171
Schistosoma mansoni lipoxygenase 0.0098 0.0437 0.0437
Echinococcus granulosus nAChR subunit 0.0038 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0054 0.018 0.018
Brugia malayi chromobox protein homolog 3 0.004 0.0097 0.0214
Schistosoma mansoni nAChR subunit 0.0038 0.0084 0.0084
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0038 0.0084 0.0084
Echinococcus granulosus peregrin 0.012 0.0567 0.0567
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0006 0.0069
Plasmodium vivax pyruvate kinase 2, putative 0.0093 0.0409 0.4413
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0084 0.0186
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0919 0.5261 1
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.028 0.028
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0092 0.0401 0.0712
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0056 0.0189 0.0189
Echinococcus multilocularis dnaJ subfamily B 0.04 0.2212 0.2212
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0054 0.018 0.1885
Onchocerca volvulus Pyruvate kinase homolog 0.0181 0.0928 0.2263
Treponema pallidum fructose-bisphosphate aldolase 0.0919 0.5261 1
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0092 0.0401 0.0401
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0016 0.0038
Brugia malayi Latrophilin receptor protein 2 0.0098 0.044 0.0972
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0092 0.0401 0.0401
Schistosoma mansoni hypothetical protein 0.0071 0.028 0.028
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0634 0.3586 0.3586
Trypanosoma brucei glucosidase, putative 0.0035 0.007 0.0384
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0088 0.0088
Toxoplasma gondii pyruvate kinase PyK1 0.0181 0.0928 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0038 0.0084 0.0084
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0123 0.0586 0.0586
Loa Loa (eye worm) hypothetical protein 0.0038 0.0084 0.0084
Schistosoma mansoni hypothetical protein 0.0098 0.044 0.044
Schistosoma mansoni aminopeptidase A (M01 family) 0.0092 0.0401 0.0401
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0054 0.018 0.1042
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0919 0.5261 1
Schistosoma mansoni phd/f-box containing protein 0.0054 0.018 0.018
Echinococcus granulosus JmjC domain containing protein 4 0.0054 0.018 0.018
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0088 0.0327
Brugia malayi Heterochromatin protein 1 0.0071 0.028 0.062
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0919 0.5261 1
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0092 0.0401 0.2352
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0038 0.0084 0.0084
Plasmodium vivax pyruvate kinase, putative 0.0181 0.0928 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0091 0.04 0.4271
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0308 0.1673 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.045 0.2506 0.2506
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0054 0.018 0.018
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0115 0.0165
Schistosoma mansoni jumonji domain containing protein 0.0054 0.018 0.018
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.007 0.008
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.007 0.007
Onchocerca volvulus 0.0123 0.0586 0.143
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0919 0.5261 1
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0836 0.1543
Onchocerca volvulus 0.0031 0.0046 0.0113
Plasmodium falciparum phd finger protein, putative 0.012 0.0567 0.6108
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0039 0.0093 0.0519
Loa Loa (eye worm) hypothetical protein 0.0181 0.0928 0.0928
Onchocerca volvulus 0.0038 0.0088 0.0215
Brugia malayi Pyruvate kinase, M2 isozyme 0.0181 0.0928 0.2051
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0038 0.0084 0.0084
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0103 0.1109
Leishmania major mitochondrial DNA polymerase beta 0.0308 0.1673 1
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0097 0.0131
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.007 0.008
Trichomonas vaginalis pyruvate kinase, putative 0.0181 0.0928 0.1719
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0016 0.0038
Mycobacterium ulcerans bacterioferritin BfrB 0.0052 0.0171 0.066
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.007 0.0695
Toxoplasma gondii PHD-finger domain-containing protein 0.012 0.0567 0.6081
Loa Loa (eye worm) hypothetical protein 0.0091 0.04 0.04
Loa Loa (eye worm) hypothetical protein 0.0038 0.0084 0.0084
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0088 0.0114
Trichomonas vaginalis chromobox protein, putative 0.0071 0.028 0.0481
Treponema pallidum bacterioferrin (TpF1) 0.0052 0.0171 0.0313
Echinococcus granulosus glycine receptor subunit alpha 1 0.0038 0.0084 0.0084
Toxoplasma gondii PHD-finger domain-containing protein 0.0039 0.0093 0.0939
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0836 0.1543
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.007 0.007
Echinococcus multilocularis chromobox protein 1 0.0071 0.028 0.028
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0159 0.0351
Brugia malayi jmjC domain containing protein 0.045 0.2506 0.554
Loa Loa (eye worm) hypothetical protein 0.0038 0.0084 0.0084
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0038 0.0084 0.0084
Brugia malayi Cation transporter family protein 0.0038 0.0084 0.0186
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0092 0.0401 0.0401
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0038 0.0084 0.0084
Leishmania major hypothetical protein, conserved 0.0038 0.0088 0.0489
Brugia malayi hypothetical protein 0.0247 0.1315 0.2907
Trichomonas vaginalis chromobox protein, putative 0.0071 0.028 0.0481
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0836 0.1543
Toxoplasma gondii PHD-finger domain-containing protein 0.012 0.0567 0.6081
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0308 0.1673 1
Giardia lamblia PHD finger protein 15 0.012 0.0567 0.0324
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0245 0.1301 0.5193
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0092 0.0401 0.0401
Echinococcus multilocularis peregrin 0.012 0.0567 0.0567
Loa Loa (eye worm) pigment dispersing factor receptor c 0.031 0.1686 0.1686
Loa Loa (eye worm) jmjC domain-containing protein 0.0247 0.1316 0.1316
Echinococcus granulosus pyruvate kinase 0.0093 0.0409 0.0409
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.04 0.04
Loa Loa (eye worm) hypothetical protein 0.004 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0026 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.001
Plasmodium falciparum pyruvate kinase 0.0181 0.0928 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0088 0.0088
Trypanosoma cruzi aminopeptidase, putative 0.0092 0.0401 0.2352
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.0202 0.0202
Mycobacterium tuberculosis Conserved protein 0.0038 0.0088 0.0327
Schistosoma mansoni hypothetical protein 0.012 0.0567 0.0567
Mycobacterium ulcerans hypothetical protein 0.0038 0.0088 0.0327
Schistosoma mansoni cpg binding protein 0.0028 0.0028 0.0028
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.007 0.008
Loa Loa (eye worm) hypothetical protein 0.0038 0.0088 0.0088
Schistosoma mansoni cpg binding protein 0.003 0.0037 0.0037
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0149 0.0149
Echinococcus granulosus phd:f box containing protein 0.0054 0.018 0.018
Brugia malayi Calcitonin receptor-like protein seb-1 0.031 0.1686 0.3728
Echinococcus granulosus jumonji domain containing 1A 0.0054 0.018 0.018
Loa Loa (eye worm) pyruvate kinase 0.0181 0.0928 0.0928
Loa Loa (eye worm) glutaminase 2 0.0286 0.1541 0.1541
Loa Loa (eye worm) hypothetical protein 0.0038 0.0084 0.0084
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.007 0.0362
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0038 0.0084 0.0084
Echinococcus granulosus lysosomal alpha glucosidase 0.0159 0.0799 0.0799
Echinococcus granulosus PHD finger protein rhinoceros 0.012 0.0567 0.0567
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0919 0.5261 1
Schistosoma mansoni pyruvate kinase 0.0181 0.0928 0.0928
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0038 0.0084 0.0186
Schistosoma mansoni ferritin 0.0052 0.0171 0.0171
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0087 0.0373 0.0825
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0016 0.0035
Mycobacterium ulcerans beta-lactamase 0.0038 0.0088 0.0327
Echinococcus granulosus lysine specific demethylase 5A 0.0204 0.1062 0.1062
Trypanosoma cruzi pyruvate kinase 2, putative 0.0181 0.0928 0.5518
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0149 0.0149
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.007 0.0122
Trypanosoma cruzi pyruvate kinase 2, putative 0.0181 0.0928 0.5518
Echinococcus granulosus cpg binding protein 0.003 0.0037 0.0037
Brugia malayi Cation transporter family protein 0.0123 0.0586 0.1296
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.1346 0.2518
Loa Loa (eye worm) hypothetical protein 0.0123 0.0586 0.0586
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0149 0.0149
Brugia malayi beta-lactamase family protein 0.0038 0.0088 0.0194
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.007 0.008
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0038 0.0084 0.0084
Echinococcus granulosus GPCR family 2 0.0098 0.044 0.044
Mycobacterium ulcerans aminopeptidase N PepN 0.0092 0.0401 0.1584
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0028 0.0028
Echinococcus multilocularis lysine specific demethylase 5A 0.0202 0.1053 0.1053
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0149 0.0149
Trypanosoma brucei aminopeptidase, putative 0.0092 0.0401 0.237
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.1346 0.2518
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.001 0.011
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0039 0.0093 0.0939
Loa Loa (eye worm) hypothetical protein 0.0097 0.0431 0.0431
Schistosoma mansoni alpha-glucosidase 0.0137 0.0668 0.0668
Schistosoma mansoni pyruvate kinase 0.0181 0.0928 0.0928
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.1346 0.2518
Chlamydia trachomatis pyruvate kinase 0.0181 0.0928 1
Loa Loa (eye worm) hypothetical protein 0.0092 0.0401 0.0401
Toxoplasma gondii aminopeptidase n, putative 0.0092 0.0401 0.4287
Echinococcus multilocularis jumonji domain containing protein 0.0167 0.0842 0.0842
Schistosoma mansoni alpha glucosidase 0.0035 0.007 0.007
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0195 0.2046
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0092 0.0401 0.237
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0092 0.0401 0.237
Loa Loa (eye worm) hypothetical protein 0.0126 0.0606 0.0606
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0038 0.0084 0.0084
Loa Loa (eye worm) aminopeptidase N 0.0092 0.0401 0.0401
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0092 0.0401 0.2352
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0088 0.0327
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0088 0.0088
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.001 0.011
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0088 0.0088
Leishmania major pyruvate kinase 0.0181 0.0928 0.5528
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0087 0.0373 0.0373
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0038 0.0084 0.0084
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0038 0.0084 0.0084
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0016 0.0018
Schistosoma mansoni phosphatidylserine receptor 0.0054 0.018 0.018
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0016 0.0018
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0052 0.0171 1
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.1346 0.2518
Loa Loa (eye worm) hypothetical protein 0.0247 0.1315 0.1315
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0088 0.0468
Schistosoma mansoni hypothetical protein 0.005 0.0159 0.0159
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0038 0.0084 0.0186
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0038 0.0084 0.0084
Onchocerca volvulus 0.0123 0.0586 0.143
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0098 0.044 0.044
Brugia malayi hypothetical protein 0.0078 0.0322 0.0711
Onchocerca volvulus Alhambra homolog 0.012 0.0567 0.1382
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0091 0.04 0.04
Loa Loa (eye worm) PHD-finger family protein 0.012 0.0567 0.0567
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0252 0.1346 0.1346
Brugia malayi glutaminase DH11.1 0.0286 0.1541 0.3407
Schistosoma mansoni apoferritin-2 0.0052 0.0171 0.0171
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0038 0.0084 0.0186
Echinococcus multilocularis pyruvate kinase 0.0181 0.0928 0.0928
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.007 0.0122
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0038 0.0084 0.0084
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.04 0.04
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0038 0.0084 0.0084
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.012 0.0567 0.0567
Echinococcus granulosus glycine receptor subunit alpha 1 0.0038 0.0084 0.0084
Toxoplasma gondii ABC1 family protein 0.0038 0.0088 0.0885
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.028 0.028
Brugia malayi pyruvate kinase, muscle isozyme 0.0038 0.0087 0.0193
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0092 0.0401 0.237
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0092 0.0401 0.0401
Brugia malayi jmjC domain containing protein 0.0054 0.018 0.0398
Onchocerca volvulus 0.005 0.0159 0.0388
Echinococcus multilocularis cpg binding protein 0.003 0.0037 0.0037
Echinococcus multilocularis jumonji domain containing 1A 0.0054 0.018 0.018
Plasmodium vivax hypothetical protein, conserved 0.012 0.0567 0.6108
Echinococcus multilocularis lysine specific demethylase 6a 0.0054 0.018 0.018
Schistosoma mansoni ferritin 0.0052 0.0171 0.0171
Echinococcus granulosus pyruvate kinase 0.0181 0.0928 0.0928
Loa Loa (eye worm) hypothetical protein 0.0026 0.0016 0.0016
Echinococcus granulosus jumonji domain containing protein 0.0167 0.0842 0.0842
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0146 0.072 0.4279
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0084 0.0186
Echinococcus multilocularis pyruvate kinase 0.0181 0.0928 0.0928
Onchocerca volvulus Pyruvate kinase homolog 0.0181 0.0928 0.2263
Onchocerca volvulus Pyruvate kinase homolog 0.0181 0.0928 0.2263
Mycobacterium ulcerans aminopeptidase N PepN 0.0092 0.0401 0.1584
Brugia malayi Pyruvate kinase, muscle isozyme 0.0181 0.0928 0.2051
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0836 0.1543
Brugia malayi jmjC domain containing protein 0.0054 0.018 0.0398
Brugia malayi jmjC domain containing protein 0.0054 0.018 0.0398
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0088 0.0114
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0016 0.0057
Loa Loa (eye worm) hypothetical protein 0.0038 0.0088 0.0088
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0016 0.0038
Onchocerca volvulus 0.0092 0.0404 0.0986
Schistosoma mansoni jumonji domain containing protein 0.0369 0.2032 0.2032
Schistosoma mansoni hypothetical protein 0.0098 0.044 0.044
Echinococcus granulosus survival motor neuron protein 1 0.0247 0.1315 0.1315
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.045 0.2506 0.2506
Onchocerca volvulus 0.0087 0.0373 0.0911
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.007 0.0384
Loa Loa (eye worm) hypothetical protein 0.012 0.0566 0.0566
Schistosoma mansoni pyruvate kinase 0.0093 0.0409 0.0409
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0097 0.0131
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.1346 0.2518
Loa Loa (eye worm) pyruvate kinase 0.0181 0.0928 0.0928
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.04 0.04
Schistosoma mansoni hypothetical protein 0.0881 0.5038 0.5038
Brugia malayi hypothetical protein 0.0092 0.0401 0.0887
Loa Loa (eye worm) peptidase family M1 containing protein 0.0092 0.0401 0.0401
Schistosoma mansoni glutaminase 0.0286 0.1541 0.1541
Loa Loa (eye worm) hypothetical protein 0.0106 0.0484 0.0484
Echinococcus multilocularis pyruvate kinase 0.0093 0.0409 0.0409
Schistosoma mansoni hypothetical protein 0.04 0.2212 0.2212
Trichomonas vaginalis pyruvate kinase, putative 0.0181 0.0928 0.1719
Schistosoma mansoni hypothetical protein 0.0081 0.0338 0.0338
Echinococcus multilocularis glycine receptor subunit beta 0.0038 0.0084 0.0084
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0115 0.0165
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0117 0.0666
Trichomonas vaginalis ferritin, putative 0.0052 0.0171 0.0272
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0084 0.0186
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0836 0.1543
Echinococcus multilocularis pyruvate kinase 0.0093 0.0409 0.0409
Schistosoma mansoni hypothetical protein 0.0098 0.044 0.044
Brugia malayi hypothetical protein 0.0793 0.4523 1
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0092 0.0401 0.2352
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0038 0.0084 0.0084
Echinococcus granulosus glycine receptor subunit beta 0.0038 0.0084 0.0084
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0449 0.25 1
Onchocerca volvulus 0.0092 0.0401 0.0979
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0092 0.0401 0.0401
Schistosoma mansoni chromobox protein 0.0071 0.028 0.028
Loa Loa (eye worm) glutaminase 0.0286 0.1541 0.1541
Brugia malayi hypothetical protein 0.012 0.0566 0.1252
Brugia malayi beta-lactamase family protein 0.0038 0.0088 0.0194
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.0799 0.0799
Onchocerca volvulus 0.0038 0.0084 0.0205
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0016 0.0038
Brugia malayi hypothetical protein 0.0092 0.0401 0.0887
Trypanosoma brucei Aminopeptidase M1, putative 0.0092 0.0401 0.237
Brugia malayi latrophilin 2 splice variant baaae 0.0212 0.1109 0.2452
Mycobacterium ulcerans hypothetical protein 0.0026 0.0016 0.0038
Loa Loa (eye worm) hypothetical protein 0.0038 0.0084 0.0084
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0836 0.1543
Echinococcus multilocularis chromobox protein 1 0.0071 0.028 0.028
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0026 0.0016 0.0016
Echinococcus multilocularis pyruvate kinase 0.0093 0.0409 0.0409
Entamoeba histolytica hypothetical protein 0.0071 0.028 0.0521
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0088 0.0327
Echinococcus granulosus L aminoadipate semialdehyde 0.0087 0.0373 0.0373
Schistosoma mansoni hypothetical protein 0.0881 0.5038 0.5038
Trypanosoma brucei Aminopeptidase M1, putative 0.0092 0.0401 0.237
Echinococcus granulosus dnaJ subfamily B 0.04 0.2212 0.2212
Mycobacterium leprae Probable pyruvate kinase PykA 0.0181 0.0928 0.3695
Schistosoma mansoni nAChR subunit 0.0038 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0038 0.0084 0.0084
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.007 0.0362
Echinococcus granulosus arachidonate 5 lipoxygenase 0.014 0.0684 0.0684
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0016 0.0018
Entamoeba histolytica aminopeptidase, putative 0.0092 0.0401 0.0752
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0054 0.018 0.1022
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0038 0.0084 0.0084
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0038 0.0084 0.0084
Onchocerca volvulus 0.0092 0.0401 0.0979
Loa Loa (eye worm) hypothetical protein 0.0038 0.0084 0.0084
Brugia malayi TATA binding protein associated factor 0.0092 0.0401 0.0887
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0038 0.0084 0.0186
Loa Loa (eye worm) hypothetical protein 0.0038 0.0088 0.0088
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0308 0.1673 1
Schistosoma mansoni nAChR subunit 0.0038 0.0084 0.0084
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0232 0.0232
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0149 0.0149
Loa Loa (eye worm) leukotriene A4 hydrolase 0.1725 1 1
Schistosoma mansoni nAChR subunit 0.0038 0.0084 0.0084
Brugia malayi PHD-finger family protein 0.0041 0.0102 0.0226
Echinococcus granulosus geminin 0.0881 0.5038 0.5038
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0052 0.0171 0.066
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0038 0.0084 0.0084
Echinococcus multilocularis glycine receptor subunit beta 0.0038 0.0084 0.0084
Echinococcus granulosus expressed protein 0.0052 0.0171 0.0171
Loa Loa (eye worm) jmjC domain-containing protein 0.0204 0.1062 0.1062
Loa Loa (eye worm) hypothetical protein 0.0123 0.0586 0.0586
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0088 0.0327
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0092 0.0401 0.0712
Brugia malayi jmjC domain containing protein 0.0204 0.1062 0.2348
Loa Loa (eye worm) hypothetical protein 0.0038 0.0088 0.0088
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0087 0.0377 0.0377
Brugia malayi AF-10 protein 0.0039 0.0093 0.0205
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0088 0.0327
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0038 0.0084 0.0186
Loa Loa (eye worm) jmjC domain-containing protein 0.0054 0.018 0.018
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0084 0.0186
Schistosoma mansoni jumonji/arid domain-containing protein 0.0204 0.1062 0.1062
Schistosoma mansoni ferritin 0.0052 0.0171 0.0171
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0212 0.1109 0.1109
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0049 0.0153 0.0153
Echinococcus granulosus lysine specific demethylase 6a 0.0054 0.018 0.018
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0016 0.0038
Loa Loa (eye worm) jmjC domain-containing protein 0.0054 0.018 0.018
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0038 0.0084 0.0084
Mycobacterium ulcerans glutaminase 0.0286 0.1541 0.6156
Onchocerca volvulus 0.0103 0.0468 0.1142
Brugia malayi CXXC zinc finger family protein 0.0028 0.0028 0.0061

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 1.07 nM Displacement of [3H]cystisine from nicotinic alpha4beta2 receptor in rat brain ChEMBL. 18262785
Ki (binding) > 10000 nM Displacement of [3H]alpha-bungaro-toxine from nicotinic alpha7 receptor in rat brain ChEMBL. 18262785

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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