Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0067 | 0.0082 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0058 | 0.0403 | 0.1299 |
Plasmodium falciparum | glutathione reductase | 0.0046 | 0.0271 | 0.2187 |
Entamoeba histolytica | hypothetical protein | 0.0339 | 0.3509 | 1 |
Mycobacterium ulcerans | glutaminase | 0.0277 | 0.2828 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.0073 | 0.0088 |
Giardia lamblia | PHD finger protein 15 | 0.0031 | 0.0103 | 0.217 |
Schistosoma mansoni | ap endonuclease | 0.0058 | 0.0403 | 0.1148 |
Echinococcus multilocularis | snurportin 1 | 0.0309 | 0.3178 | 0.3178 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0105 | 0.0921 | 0.0921 |
Brugia malayi | RNA, U transporter 1 | 0.0082 | 0.0674 | 0.0821 |
Schistosoma mansoni | hypothetical protein | 0.0335 | 0.3467 | 0.9879 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.0455 | 0.1296 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.1317 | 0.1605 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0107 | 0.0947 | 0.3056 |
Leishmania major | DNA polymerase eta, putative | 0.0048 | 0.03 | 0.0969 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0092 | 0.0777 | 0.0777 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0064 | 0.0473 | 0.1347 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0116 | 0.105 | 0.1104 |
Mycobacterium tuberculosis | Probable reductase | 0.0105 | 0.0921 | 0.0921 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0064 | 0.0473 | 0.0289 |
Schistosoma mansoni | importin beta-1 | 0.0029 | 0.0084 | 0.0241 |
Entamoeba histolytica | hypothetical protein | 0.0339 | 0.3509 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0107 | 0.0947 | 0.1215 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0058 | 0.0403 | 0.1299 |
Leishmania major | hypothetical protein, conserved | 0.0134 | 0.1242 | 0.4005 |
Giardia lamblia | DINP protein human, muc B family | 0.0064 | 0.0473 | 1 |
Echinococcus multilocularis | musashi | 0.0028 | 0.0073 | 0.0073 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0064 | 0.0473 | 0.0286 |
Onchocerca volvulus | 0.0049 | 0.0301 | 0.0295 | |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0684 | 0.7321 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0639 | 0.6825 | 0.8313 |
Echinococcus granulosus | importin subunit beta 1 | 0.0029 | 0.0084 | 0.0103 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0116 | 0.105 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0107 | 0.0947 | 0.1154 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0046 | 0.0271 | 0.0331 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0495 | 0.524 | 0.6382 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0064 | 0.0473 | 0.1525 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0092 | 0.0777 | 0.2215 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0034 | 0.0138 | 0.0168 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0046 | 0.0271 | 0.0876 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0107 | 0.0947 | 0.2246 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0134 | 0.1242 | 0.4005 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0048 | 0.03 | 0.2419 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0231 | 0.2323 | 0.2829 |
Schistosoma mansoni | ap endonuclease | 0.0058 | 0.0403 | 0.1148 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0107 | 0.0947 | 0.1154 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0134 | 0.1242 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0309 | 0.3178 | 0.9056 |
Loa Loa (eye worm) | beta-lactamase | 0.0107 | 0.0947 | 0.1154 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0058 | 0.0403 | 0.0491 |
Loa Loa (eye worm) | glutaminase 2 | 0.0277 | 0.2828 | 0.3445 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0031 | 0.0103 | 0.0125 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0064 | 0.0473 | 0.1525 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0037 | 0.0174 | 0.0495 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0143 | 0.1343 | 0.4333 |
Brugia malayi | MH2 domain containing protein | 0.0034 | 0.0138 | 0.0168 |
Schistosoma mansoni | smad1 5 8 and | 0.0034 | 0.0138 | 0.0392 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0058 | 0.0403 | 0.1148 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0064 | 0.0473 | 0.1525 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0062 | 0.0455 | 0.0554 |
Entamoeba histolytica | hypothetical protein | 0.0339 | 0.3509 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0134 | 0.1242 | 0.4005 |
Brugia malayi | follicle stimulating hormone receptor | 0.0238 | 0.2398 | 0.292 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0092 | 0.0777 | 0.0947 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0065 | 0.0483 | 0.0483 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0064 | 0.0473 | 0.1525 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0034 | 0.0138 | 0.0138 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0031 | 0.0103 | 0.0292 |
Echinococcus granulosus | lamin | 0.0028 | 0.0073 | 0.0088 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0034 | 0.0138 | 0.0168 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0107 | 0.0947 | 0.1215 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0231 | 0.2323 | 0.6618 |
Schistosoma mansoni | lamin | 0.0028 | 0.0073 | 0.0207 |
Trichomonas vaginalis | glutaminase, putative | 0.0277 | 0.2828 | 0.3626 |
Trichomonas vaginalis | set domain proteins, putative | 0.0727 | 0.78 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0073 | 0.0088 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0029 | 0.0084 | 0.0084 |
Schistosoma mansoni | hypothetical protein | 0.006 | 0.0427 | 0.1217 |
Brugia malayi | MH2 domain containing protein | 0.0495 | 0.524 | 0.6382 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0034 | 0.0138 | 0.0168 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0339 | 0.3509 | 0.3509 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0037 | 0.0174 | 0.0495 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0947 | 0.1154 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.014 | 0.1317 | 0.1605 |
Schistosoma mansoni | hypothetical protein | 0.0339 | 0.3509 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0058 | 0.0403 | 0.1299 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0107 | 0.0947 | 0.0959 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0495 | 0.524 | 0.6382 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0764 | 0.821 | 1 |
Echinococcus granulosus | snurportin 1 | 0.0309 | 0.3178 | 0.3871 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0107 | 0.0947 | 0.2246 |
Schistosoma mansoni | jumonji domain containing protein | 0.008 | 0.0644 | 0.1835 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0046 | 0.0271 | 0.2187 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0339 | 0.3509 | 0.4275 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0344 | 0.0419 |
Entamoeba histolytica | hypothetical protein | 0.0339 | 0.3509 | 1 |
Schistosoma mansoni | lamin | 0.0028 | 0.0073 | 0.0207 |
Trypanosoma brucei | unspecified product | 0.0044 | 0.0253 | 0.0816 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0.0024 | 0.0068 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0046 | 0.0271 | 0.0331 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0116 | 0.105 | 0.1104 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0092 | 0.0777 | 0.2215 |
Schistosoma mansoni | smad | 0.0034 | 0.0138 | 0.0392 |
Echinococcus granulosus | jumonji domain containing protein | 0.0043 | 0.0235 | 0.0286 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0107 | 0.0947 | 0.0959 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0107 | 0.0947 | 0.1215 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0107 | 0.0947 | 0.0959 |
Echinococcus multilocularis | Smad4 | 0.0034 | 0.0138 | 0.0138 |
Toxoplasma gondii | ABC1 family protein | 0.0107 | 0.0947 | 0.7631 |
Onchocerca volvulus | 0.0107 | 0.0947 | 0.1132 | |
Brugia malayi | glutaminase DH11.1 | 0.0277 | 0.2828 | 0.3445 |
Plasmodium vivax | SET domain protein, putative | 0.0092 | 0.0777 | 0.626 |
Echinococcus granulosus | dna polymerase kappa | 0.0064 | 0.0473 | 0.0576 |
Brugia malayi | MH2 domain containing protein | 0.0034 | 0.0138 | 0.0168 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0037 | 0.0174 | 0.0212 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0064 | 0.0473 | 0.1525 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0042 | 0.0234 | 0.0754 |
Echinococcus granulosus | GPCR family 2 | 0.0065 | 0.0483 | 0.0589 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0205 | 0.2036 | 0.248 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0043 | 0.0235 | 0.0235 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0107 | 0.0947 | 0.3056 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0639 | 0.6825 | 0.8313 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0058 | 0.0403 | 0.0516 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0084 | 0.0272 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0042 | 0.0234 | 0.0754 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.01 | 0.0871 | 0.0871 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.0483 | 0.1377 |
Trichomonas vaginalis | esterase, putative | 0.0107 | 0.0947 | 0.1215 |
Brugia malayi | jmjC domain containing protein | 0.01 | 0.0871 | 0.1062 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 0.0073 | 0.0207 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0042 | 0.0234 | 0.0754 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0231 | 0.2323 | 0.2829 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0062 | 0.0455 | 0.1467 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0058 | 0.0403 | 0.3244 |
Schistosoma mansoni | DNA polymerase eta | 0.0093 | 0.0789 | 0.2247 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0107 | 0.0947 | 0.1154 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0024 | 0.0031 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0107 | 0.0947 | 0.0959 |
Leishmania major | importin beta-1 subunit, putative | 0.0023 | 0.0024 | 0.0077 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0302 | 0.31 | 1 |
Echinococcus granulosus | peregrin | 0.0031 | 0.0103 | 0.0125 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0029 | 0.0084 | 0.068 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0092 | 0.0777 | 0.2215 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.01 | 0.0871 | 0.1062 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0031 | 0.0103 | 0.0826 |
Toxoplasma gondii | hypothetical protein | 0.0049 | 0.0303 | 0.2438 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0103 | 0.0292 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0789 | 0.0961 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0309 | 0.3178 | 0.3871 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0064 | 0.0473 | 0.1347 |
Schistosoma mansoni | Smad4 | 0.0034 | 0.0138 | 0.0392 |
Echinococcus multilocularis | peregrin | 0.0031 | 0.0103 | 0.0103 |
Echinococcus multilocularis | smad | 0.0034 | 0.0138 | 0.0138 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0084 | 0.0103 |
Brugia malayi | hypothetical protein | 0.0086 | 0.0718 | 0.0875 |
Mycobacterium tuberculosis | Conserved protein | 0.0107 | 0.0947 | 0.0959 |
Mycobacterium ulcerans | hypothetical protein | 0.0107 | 0.0947 | 0.2246 |
Schistosoma mansoni | hypothetical protein | 0.014 | 0.1317 | 0.3754 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0107 | 0.0947 | 0.27 |
Brugia malayi | jmjC domain containing protein | 0.0037 | 0.0174 | 0.0212 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0064 | 0.0473 | 0.0576 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0764 | 0.821 | 0.821 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0231 | 0.2323 | 0.2829 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0064 | 0.0473 | 0.1525 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0107 | 0.0947 | 0.1215 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0065 | 0.0483 | 0.0589 |
Brugia malayi | PHD-finger family protein | 0.0031 | 0.0103 | 0.0125 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0064 | 0.0473 | 0.0473 |
Brugia malayi | Smad1 | 0.0034 | 0.0138 | 0.0168 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0134 | 0.1242 | 0.4005 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0031 | 0.0103 | 0.0826 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0116 | 0.105 | 0.1104 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.0483 | 0.1377 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0238 | 0.2398 | 0.292 |
Loa Loa (eye worm) | glutathione reductase | 0.0046 | 0.0271 | 0.0331 |
Mycobacterium ulcerans | beta-lactamase | 0.0107 | 0.0947 | 0.2246 |
Echinococcus granulosus | dna polymerase eta | 0.0093 | 0.0789 | 0.0961 |
Trypanosoma brucei | trypanothione reductase | 0.0046 | 0.0271 | 0.0876 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.0777 | 0.0947 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0143 | 0.1343 | 0.4333 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0947 | 0.1154 |
Plasmodium falciparum | importin beta, putative | 0.0029 | 0.0084 | 0.068 |
Schistosoma mansoni | hypothetical protein | 0.0335 | 0.3467 | 0.9879 |
Leishmania major | trypanothione reductase | 0.0046 | 0.0271 | 0.0876 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0947 | 0.1154 |
Trypanosoma brucei | unspecified product | 0.0044 | 0.0253 | 0.0816 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0947 | 0.1154 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0064 | 0.0473 | 0.1525 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0049 | 0.0301 | 0.0857 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0062 | 0.0455 | 0.0455 |
Echinococcus granulosus | smad | 0.0034 | 0.0138 | 0.0168 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0064 | 0.0473 | 0.1347 |
Plasmodium vivax | importin-beta 2, putative | 0.0029 | 0.0084 | 0.068 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0065 | 0.0483 | 0.0589 |
Plasmodium falciparum | phd finger protein, putative | 0.0031 | 0.0103 | 0.0826 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0064 | 0.0473 | 0.1525 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0064 | 0.0473 | 0.1525 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0064 | 0.0473 | 0.1525 |
Mycobacterium tuberculosis | Conserved protein | 0.0107 | 0.0947 | 0.0959 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0107 | 0.0947 | 0.0959 |
Echinococcus multilocularis | dna polymerase kappa | 0.0064 | 0.0473 | 0.0473 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0107 | 0.0947 | 0.0959 |
Toxoplasma gondii | thioredoxin reductase | 0.0046 | 0.0271 | 0.2187 |
Plasmodium falciparum | thioredoxin reductase | 0.0046 | 0.0271 | 0.2187 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.0073 | 0.0088 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.006 | 0.0427 | 0.052 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0023 | 0.0024 | 0.0077 |
Brugia malayi | hypothetical protein | 0.0764 | 0.821 | 1 |
Onchocerca volvulus | 0.0727 | 0.78 | 1 | |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0092 | 0.0777 | 0.2215 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0065 | 0.0483 | 0.0589 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.0073 | 0.0088 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.0073 | 0.0073 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0064 | 0.0473 | 0.1525 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0301 | 0.0366 |
Onchocerca volvulus | 0.0156 | 0.1487 | 0.1831 | |
Brugia malayi | Bromodomain containing protein | 0.0031 | 0.0103 | 0.0125 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0046 | 0.0271 | 0.0271 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0058 | 0.0403 | 0.0491 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0034 | 0.0138 | 0.0138 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0134 | 0.1242 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0134 | 0.1242 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0064 | 0.0473 | 0.0289 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0159 | 0.1522 | 0.1773 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0064 | 0.0473 | 0.1525 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0339 | 0.3509 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0134 | 0.1242 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0331 | 0.3428 | 0.3428 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0058 | 0.0403 | 0.0491 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0092 | 0.0777 | 0.626 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.0483 | 0.1377 |
Echinococcus multilocularis | lamin | 0.0028 | 0.0073 | 0.0073 |
Onchocerca volvulus | 0.0092 | 0.0777 | 0.0912 | |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0058 | 0.0403 | 0.0186 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0947 | 0.1154 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0092 | 0.0777 | 0.0777 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0107 | 0.0947 | 0.1154 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0483 | 0.0589 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0064 | 0.0473 | 0.0606 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0231 | 0.2323 | 0.2323 |
Brugia malayi | glutathione reductase | 0.0046 | 0.0271 | 0.0331 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0058 | 0.0403 | 0.1299 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0044 | 0.0253 | 0.0816 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0031 | 0.0103 | 0.0103 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.2036 | 0.248 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0088 | 0.074 | 0.0901 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0042 | 0.0234 | 0.0754 |
Loa Loa (eye worm) | glutaminase | 0.0277 | 0.2828 | 0.3445 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0044 | 0.0253 | 0.0816 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0205 | 0.2036 | 0.248 |
Plasmodium vivax | glutathione reductase, putative | 0.0046 | 0.0271 | 0.2187 |
Brugia malayi | beta-lactamase family protein | 0.0107 | 0.0947 | 0.1154 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0107 | 0.0947 | 0.0947 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.006 | 0.0427 | 0.0427 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0093 | 0.0789 | 0.2544 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0058 | 0.0403 | 0.8518 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0302 | 0.31 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0156 | 0.1487 | 0.4238 |
Brugia malayi | Pre-SET motif family protein | 0.0092 | 0.0777 | 0.0947 |
Brugia malayi | hypothetical protein | 0.0134 | 0.1242 | 0.1512 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.0483 | 0.1377 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0143 | 0.1343 | 0.4333 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0105 | 0.0921 | 0.0921 |
Toxoplasma gondii | exonuclease III APE | 0.0058 | 0.0403 | 0.3244 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0231 | 0.2323 | 0.2829 |
Schistosoma mansoni | glutaminase | 0.0277 | 0.2828 | 0.8059 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0093 | 0.0789 | 0.2544 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0064 | 0.0473 | 0.1525 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.1242 | 0.1512 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0107 | 0.0947 | 0.0959 |
Loa Loa (eye worm) | hypothetical protein | 0.0764 | 0.821 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0107 | 0.0947 | 0.3056 |
Echinococcus multilocularis | dna polymerase eta | 0.0093 | 0.0789 | 0.0789 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.0455 | 0.1296 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0103 | 0.0125 |
Mycobacterium tuberculosis | Conserved protein | 0.0107 | 0.0947 | 0.0959 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0058 | 0.0403 | 0.0403 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0947 | 0.1154 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0062 | 0.0455 | 0.3664 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0065 | 0.0483 | 0.0589 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0064 | 0.0473 | 0.1525 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0065 | 0.0483 | 0.0483 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0064 | 0.0473 | 0.0576 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0034 | 0.0138 | 0.0168 |
Leishmania major | DNA polymerase kappa, putative | 0.0064 | 0.0473 | 0.1525 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.0073 | 0.0088 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.0455 | 0.0215 |
Brugia malayi | beta-lactamase | 0.0107 | 0.0947 | 0.1154 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0065 | 0.0483 | 0.0589 |
Plasmodium vivax | hypothetical protein, conserved | 0.0031 | 0.0103 | 0.0826 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0034 | 0.0138 | 0.0392 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0063 | 0.0462 | 0.0563 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0302 | 0.31 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0034 | 0.0138 | 0.0392 |
Mycobacterium leprae | conserved hypothetical protein | 0.0107 | 0.0947 | 0.2064 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0107 | 0.0947 | 0.3056 |
Brugia malayi | MH1 domain containing protein | 0.0034 | 0.0138 | 0.0168 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0205 | 0.2036 | 0.248 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0052 | 0.0336 | 0.1085 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0064 | 0.0473 | 0.1525 |
Loa Loa (eye worm) | Smad1 | 0.0034 | 0.0138 | 0.0168 |
Onchocerca volvulus | 0.0107 | 0.0947 | 0.1132 | |
Trichomonas vaginalis | ap endonuclease, putative | 0.0058 | 0.0403 | 0.0516 |
Plasmodium vivax | hypothetical protein, conserved | 0.0107 | 0.0947 | 0.7631 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0064 | 0.0473 | 0.0286 |
Echinococcus granulosus | geminin | 0.0335 | 0.3467 | 0.4223 |
Mycobacterium ulcerans | hypothetical protein | 0.0159 | 0.1522 | 0.4613 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0231 | 0.2323 | 0.6618 |
Brugia malayi | Importin beta-1 subunit | 0.0029 | 0.0084 | 0.0103 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0107 | 0.0947 | 0.1215 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0105 | 0.0921 | 0.0921 |
Mycobacterium leprae | Probable lipase LipE | 0.0107 | 0.0947 | 0.2064 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0105 | 0.0921 | 0.0921 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0064 | 0.0473 | 0.0606 |
Schistosoma mansoni | survival motor neuron protein | 0.0156 | 0.1487 | 0.4238 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0064 | 0.0473 | 0.1525 |
Brugia malayi | hypothetical protein | 0.0339 | 0.3509 | 0.4275 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0064 | 0.0473 | 0.1525 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0058 | 0.0403 | 0.5 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0037 | 0.0174 | 0.0212 |
Trichomonas vaginalis | importin beta-1, putative | 0.0023 | 0.0024 | 0.0031 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.0455 | 0.0215 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0302 | 0.31 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0093 | 0.0789 | 0.0961 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0058 | 0.0403 | 0.3244 |
Echinococcus multilocularis | GPCR, family 2 | 0.0065 | 0.0483 | 0.0483 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0048 | 0.03 | 0.0969 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0231 | 0.2323 | 0.2323 |
Leishmania major | DNA polymerase eta, putative | 0.0093 | 0.0789 | 0.2544 |
Brugia malayi | MH1 domain containing protein | 0.0034 | 0.0138 | 0.0168 |
Schistosoma mansoni | smad1 5 8 and | 0.0034 | 0.0138 | 0.0392 |
Echinococcus multilocularis | geminin | 0.0335 | 0.3467 | 0.3467 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0062 | 0.0455 | 0.026 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.0073 | 0.0088 |
Trypanosoma brucei | unspecified product | 0.0064 | 0.0473 | 0.1525 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0044 | 0.0253 | 0.0816 |
Onchocerca volvulus | Alhambra homolog | 0.0031 | 0.0103 | 0.0039 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0084 | 0.0272 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0024 | 0.0031 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0064 | 0.0473 | 0.0576 |
Onchocerca volvulus | 0.0107 | 0.0947 | 0.1132 | |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0156 | 0.1487 | 0.1812 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0107 | 0.0947 | 0.27 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0064 | 0.0473 | 0.1525 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0058 | 0.0403 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0046 | 0.0271 | 0.0331 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0037 | 0.0174 | 0.0174 |
Echinococcus granulosus | tumor protein p63 | 0.0331 | 0.3428 | 0.4175 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0105 | 0.0921 | 0.0921 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0031 | 0.0103 | 0.0125 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.0455 | 0.0215 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.0073 | 0.0088 |
Echinococcus granulosus | Smad4 | 0.0034 | 0.0138 | 0.0168 |
Mycobacterium ulcerans | lipase LipD | 0.0107 | 0.0947 | 0.2246 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0231 | 0.2323 | 0.6618 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Inhibition of NorA efflux pump in Staphylococcus aureus K2378 overexpressing NorA efflux pump assessed as potentiation of EtBr uptake at 3 uM | ChEMBL. | 19419877 | |
Activity (binding) | Inhibition of NorA efflux pump in wild type Staphylococcus aureus 8325-4 assessed as potentiation of EtBr uptake at 3 uM | ChEMBL. | 19419877 | |
Activity (binding) | Inhibition of NorA efflux pump in Staphylococcus aureus K1758 NorA efflux pump-deficient mutant assessed as increase in berberine accumulation at 3 uM | ChEMBL. | 19419877 | |
Activity (binding) | Inhibition of NorA efflux pump in Staphylococcus aureus K2378 overexpressing NorA efflux pump overexpressing NorA efflux pump assessed as increase in berberine accumulation at 3 uM | ChEMBL. | 19419877 | |
Activity (binding) | Inhibition of NorA efflux pump in wild type Staphylococcus aureus 8325-4 assessed as increase in berberine accumulation at 3 uM | ChEMBL. | 19419877 | |
Activity (binding) | Inhibition of NorA efflux pump in Staphylococcus aureus K1758 NorA efflux pump-deficient mutant assessed as potentiation of EtBr uptake at 3 uM | ChEMBL. | 19419877 | |
Activity (binding) | Inhibition of NorA efflux pump in Staphylococcus aureus K2378 overexpressing NorA efflux pump assessed as inhibition of EtBr efflux at 3 uM | ChEMBL. | 19419877 | |
MIC (functional) | > 150 uM | Antibacterial activity against Escherichia coli BW-25116 TolC-deficient mutant after 18 hrs by twofold serial dilution method | ChEMBL. | 19419877 |
MIC (functional) | > 150 uM | Antibacterial activity against Escherichia coli ECM116 mar1642 overexpressing ArcAB pump after 18 hrs by twofold serial dilution method | ChEMBL. | 19419877 |
MIC (functional) | > 150 uM | Antibacterial activity against Escherichia coli ECM1642 after 18 hrs by twofold serial dilution method | ChEMBL. | 19419877 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.