Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Protein kinase domain containing protein | 0.0186 | 0.631 | 0.8313 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0012 | 0.0232 | 0.0232 |
Onchocerca volvulus | 0.0021 | 0.0521 | 0.0601 | |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0012 | 0.0232 | 0.0367 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.0186 | 0.631 | 1 |
Loa Loa (eye worm) | GABA receptor subunit | 0.0007 | 0.0033 | 0.0044 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0012 | 0.0232 | 0.0305 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0012 | 0.0232 | 0.0305 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0006 | 0.0006 | 0.0007 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0032 | 0.0908 | 0.2803 |
Entamoeba histolytica | hypothetical protein | 0.0021 | 0.0531 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0032 | 0.0908 | 0.2803 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0032 | 0.0908 | 0.0948 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0032 | 0.0908 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0012 | 0.0232 | 0.0305 |
Entamoeba histolytica | thioredoxin reductase, putative | 0.0008 | 0.0095 | 0.1241 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0032 | 0.0919 | 0.1456 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0032 | 0.0908 | 0.2803 |
Schistosoma mansoni | hypothetical protein | 0.0008 | 0.0095 | 0.0095 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0006 | 0.0006 | 0.001 |
Echinococcus multilocularis | pyridine nucleotide disulfide oxidoreductase | 0.0008 | 0.0095 | 0.0151 |
Onchocerca volvulus | 0.0012 | 0.0232 | 0.0268 | |
Entamoeba histolytica | hypothetical protein | 0.0021 | 0.0531 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0091 | 0.2993 | 1 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0012 | 0.0232 | 0.0367 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0232 | 0.0305 |
Schistosoma mansoni | sulfide quinone reductase | 0.0008 | 0.0095 | 0.0095 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0012 | 0.0232 | 0.0367 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.1517 | 0.1998 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0021 | 0.0521 | 0.147 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0223 | 0.7591 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0026 | 0.0708 | 0.1123 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0033 | 0.0044 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0012 | 0.0232 | 0.0367 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0521 | 0.0687 |
Echinococcus granulosus | nAChR subunit | 0.0007 | 0.0033 | 0.0053 |
Mycobacterium tuberculosis | Conserved protein | 0.0021 | 0.0521 | 0.0546 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0032 | 0.0919 | 0.1456 |
Echinococcus granulosus | nAChR subunit | 0.0012 | 0.0232 | 0.0367 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0006 | 0.0006 | 0.001 |
Onchocerca volvulus | 0.0021 | 0.0521 | 0.0601 | |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0021 | 0.0531 | 0.0841 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0012 | 0.0232 | 0.0232 |
Loa Loa (eye worm) | ACC-1 protein | 0.0012 | 0.0232 | 0.0305 |
Brugia malayi | Cation transporter family protein | 0.0012 | 0.0232 | 0.0305 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0073 | 0.2354 | 0.373 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0032 | 0.0908 | 0.2803 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0026 | 0.0708 | 0.1123 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0006 | 0.0006 | 0.001 |
Echinococcus multilocularis | nAChR subunit | 0.0007 | 0.0033 | 0.0053 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0033 | 0.0044 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0091 | 0.2993 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0006 | 0.0006 | 0.0008 |
Entamoeba histolytica | glutamate synthase beta subunit, putative | 0.0008 | 0.0095 | 0.1241 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0521 | 0.0687 |
Entamoeba histolytica | hypothetical protein | 0.0021 | 0.0531 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0012 | 0.0232 | 0.0305 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase family protein | 0.0008 | 0.0095 | 0.0125 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0232 | 0.0305 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0021 | 0.0521 | 0.0826 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0008 | 0.0095 | 0.1241 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0091 | 0.2993 | 0.3944 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0008 | 0.0095 | 0.0151 |
Loa Loa (eye worm) | programmed cell death 8 | 0.0008 | 0.0095 | 0.0125 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0033 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0708 | 0.0933 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0006 | 0.0006 | 0.0006 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0021 | 0.0521 | 0.0546 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0006 | 0.0006 | 0.001 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.0919 | 0.0919 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0006 | 0.0006 | 0.001 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0012 | 0.0232 | 0.0367 |
Brugia malayi | nuclear hormone receptor | 0.0006 | 0.0006 | 0.0008 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0032 | 0.0908 | 0.2803 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0032 | 0.0908 | 0.2803 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0026 | 0.0708 | 0.0933 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0079 | 0.2558 | 0.4055 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0232 | 0.0305 |
Trichomonas vaginalis | set domain proteins, putative | 0.0254 | 0.8667 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0021 | 0.0521 | 0.0826 |
Mycobacterium ulcerans | beta-lactamase | 0.0021 | 0.0521 | 0.5244 |
Schistosoma mansoni | disulfide oxidoreductase | 0.0008 | 0.0095 | 0.0095 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0021 | 0.0521 | 0.0687 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.0919 | 0.0919 |
Echinococcus multilocularis | apoptosis inducing factor 1 mitochondrial | 0.0008 | 0.0095 | 0.0151 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0006 | 0.0006 | 0.0008 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0021 | 0.0521 | 0.0521 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0006 | 0.0006 | 0.0008 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0032 | 0.0908 | 0.2803 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase family protein | 0.0008 | 0.0095 | 0.0125 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0082 | 0.2668 | 0.3514 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0012 | 0.0232 | 0.0305 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0006 | 0.0006 | 0.0006 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0032 | 0.0908 | 0.2803 |
Brugia malayi | steroid hormone receptor | 0.0006 | 0.0006 | 0.0008 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0232 | 0.0305 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0006 | 0.0006 | 0.0008 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0006 | 0.0006 | 0.001 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0007 | 0.0033 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0033 | 0.0044 |
Leishmania major | trypanothione reductase | 0.0091 | 0.2993 | 1 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.0186 | 0.631 | 0.8313 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0006 | 0.0006 | 0.0008 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0012 | 0.0232 | 0.0232 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0012 | 0.0232 | 0.0305 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0132 | 0.4399 | 0.5518 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0021 | 0.0521 | 0.0546 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0021 | 0.0521 | 0.0497 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0006 | 0.0008 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0091 | 0.2993 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0032 | 0.0908 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0006 | 0.0006 | 0.001 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0012 | 0.0232 | 0.0367 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0021 | 0.0521 | 0.0497 |
Brugia malayi | Cation transporter family protein | 0.0012 | 0.0232 | 0.0305 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0032 | 0.0908 | 1 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0012 | 0.0232 | 0.0367 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0006 | 0.0006 | 0.0006 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0032 | 0.0908 | 0.2803 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0006 | 0.0006 | 0.0008 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0006 | 0.0008 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0186 | 0.631 | 0.631 |
Schistosoma mansoni | nicotinic acetylcholine receptor alpha | 0.0007 | 0.0033 | 0.0033 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0023 | 0.0614 | 0.0809 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0531 | 0.0531 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0006 | 0.0008 |
Brugia malayi | Pre-SET motif family protein | 0.0032 | 0.0919 | 0.121 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0012 | 0.0232 | 0.0305 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0032 | 0.0908 | 1 |
Onchocerca volvulus | 0.0012 | 0.0232 | 0.0268 | |
Brugia malayi | nuclear receptor NHR-88 | 0.0006 | 0.0006 | 0.0008 |
Onchocerca volvulus | 0.0012 | 0.0232 | 0.0268 | |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.0007 | 0.0033 | 0.0033 |
Mycobacterium tuberculosis | Probable reductase | 0.0209 | 0.7083 | 0.8958 |
Brugia malayi | Pre-SET motif family protein | 0.0223 | 0.7591 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0012 | 0.0232 | 0.0305 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.0919 | 0.0919 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0032 | 0.0908 | 0.2803 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0012 | 0.0232 | 0.0305 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0021 | 0.0521 | 0.0546 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0012 | 0.0232 | 0.0305 |
Schistosoma mansoni | sulfide quinone reductase | 0.0008 | 0.0095 | 0.0095 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0006 | 0.0006 | 0.0008 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0521 | 0.0687 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0209 | 0.7083 | 0.8958 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0006 | 0.0008 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0032 | 0.0919 | 0.2842 |
Schistosoma mansoni | nAChR subunit | 0.0012 | 0.0232 | 0.0232 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0006 | 0.0006 | 0.001 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0032 | 0.0908 | 0.2803 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0006 | 0.0006 | 0.0008 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0032 | 0.0908 | 1 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0032 | 0.0908 | 0.2803 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0012 | 0.0232 | 0.0305 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.2354 | 0.2354 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0032 | 0.0908 | 0.2803 |
Brugia malayi | Thioredoxin reductase | 0.0091 | 0.2993 | 0.3944 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0007 | 0.0033 | 0.0044 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0082 | 0.2668 | 0.3514 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0232 | 0.0305 |
Echinococcus multilocularis | glutamate synthase | 0.0008 | 0.0095 | 0.0151 |
Echinococcus granulosus | sulfide:quinone oxidoreductase | 0.0008 | 0.0095 | 0.0151 |
Loa Loa (eye worm) | LGC-31 protein | 0.0012 | 0.0232 | 0.0305 |
Schistosoma mansoni | glutamate synthase | 0.0008 | 0.0095 | 0.0095 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.1517 | 0.1517 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0209 | 0.7083 | 0.8958 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0012 | 0.0232 | 0.0305 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0232 | 0.0305 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0012 | 0.0232 | 0.0305 |
Trichomonas vaginalis | esterase, putative | 0.0021 | 0.0521 | 0.0497 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.2668 | 0.3514 |
Entamoeba histolytica | hypothetical protein | 0.0021 | 0.0531 | 1 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0032 | 0.0908 | 0.2803 |
Entamoeba histolytica | pyridine nucleotide-disulfide oxidoreductase family protein | 0.0008 | 0.0095 | 0.1241 |
Echinococcus multilocularis | NADPH:adrenodoxin oxidoreductase | 0.0008 | 0.0095 | 0.0151 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0232 | 0.0305 |
Entamoeba histolytica | glutamate synthase beta subunit, putative | 0.0008 | 0.0095 | 0.1241 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0006 | 0.0006 | 0.0007 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0006 | 0.0006 | 0.0008 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0082 | 0.2668 | 0.3514 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0033 | 0.0044 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0069 | 0.2222 | 0.2927 |
Schistosoma mansoni | hypothetical protein | 0.0026 | 0.0708 | 0.0708 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0033 | 0.0044 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0006 | 0.0006 | 0.0008 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0232 | 0.7895 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0232 | 0.0305 |
Brugia malayi | glutamate-gated chloride channel alpha3A subunit, putative | 0.0007 | 0.0033 | 0.0044 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0209 | 0.7083 | 0.8958 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0012 | 0.0232 | 0.0305 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0209 | 0.7083 | 0.8958 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0006 | 0.0006 | 0.0008 |
Echinococcus granulosus | NADPH:adrenodoxin oxidoreductase | 0.0008 | 0.0095 | 0.0151 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.0186 | 0.631 | 0.728 |
Echinococcus granulosus | GPCR family 2 | 0.0026 | 0.0708 | 0.1123 |
Plasmodium vivax | SET domain protein, putative | 0.0032 | 0.0919 | 0.2842 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0032 | 0.0908 | 0.2803 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0012 | 0.0232 | 0.0232 |
Brugia malayi | glutathione reductase | 0.0091 | 0.2993 | 0.3944 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0032 | 0.0908 | 0.2803 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0232 | 0.7895 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0006 | 0.0006 | 0.0008 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0209 | 0.7083 | 0.8958 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0021 | 0.0521 | 0.5244 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0032 | 0.0908 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0006 | 0.0008 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0032 | 0.0908 | 0.2803 |
Brugia malayi | beta-lactamase | 0.0021 | 0.0521 | 0.0687 |
Toxoplasma gondii | thioredoxin reductase | 0.0091 | 0.2993 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0012 | 0.0232 | 0.0232 |
Schistosoma mansoni | thyroid hormone receptor | 0.0079 | 0.2558 | 0.2558 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0023 | 0.0614 | 0.0809 |
Onchocerca volvulus | 0.0254 | 0.8667 | 1 | |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0026 | 0.0708 | 0.1123 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0032 | 0.0908 | 0.1438 |
Brugia malayi | beta-lactamase family protein | 0.0021 | 0.0521 | 0.0687 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0006 | 0.0006 | 0.0006 |
Leishmania major | hypothetical protein, conserved | 0.0021 | 0.0521 | 0.147 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0012 | 0.0232 | 0.0367 |
Treponema pallidum | NADH oxidase | 0.0032 | 0.0908 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0232 | 0.0305 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0006 | 0.0006 | 0.0006 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0032 | 0.0908 | 0.0948 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0032 | 0.0908 | 0.2803 |
Schistosoma mansoni | nAChR subunit | 0.0012 | 0.0232 | 0.0232 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0008 | 0.0095 | 0.0151 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0006 | 0.0006 | 0.0006 |
Mycobacterium ulcerans | lipase LipD | 0.0021 | 0.0521 | 0.5244 |
Mycobacterium leprae | conserved hypothetical protein | 0.0021 | 0.0521 | 0.0546 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0021 | 0.0521 | 0.0546 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0012 | 0.0232 | 0.0367 |
Onchocerca volvulus | 0.0021 | 0.0521 | 0.0601 | |
Echinococcus granulosus | glutamate synthase | 0.0008 | 0.0095 | 0.0151 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0006 | 0.0006 | 0.0008 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0032 | 0.0908 | 0.2803 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0021 | 0.0521 | 0.0497 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0006 | 0.0006 | 0.0006 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0012 | 0.0232 | 0.0367 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0232 | 0.0305 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0008 | 0.0095 | 0.0151 |
Entamoeba histolytica | NAD(FAD)-dependent dehydrogenase, putative | 0.0008 | 0.0095 | 0.1241 |
Onchocerca volvulus | 0.0032 | 0.0919 | 0.106 | |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0032 | 0.0908 | 0.1438 |
Plasmodium vivax | glutathione reductase, putative | 0.0091 | 0.2993 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0095 | 0.0125 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0006 | 0.0006 | 0.001 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0056 | 0.1761 | 0.232 |
Echinococcus granulosus | pyridine nucleotide disulfide oxidoreductase | 0.0008 | 0.0095 | 0.0151 |
Entamoeba histolytica | disulphide oxidoreductase, putative | 0.0008 | 0.0095 | 0.1241 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0032 | 0.0908 | 0.2803 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0012 | 0.0232 | 0.0367 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0012 | 0.0232 | 0.0367 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0032 | 0.0908 | 0.1042 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0092 | 0.3012 | 0.4774 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0012 | 0.0232 | 0.0367 |
Onchocerca volvulus | Putative nachr subunit | 0.0012 | 0.0232 | 0.0268 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0069 | 0.2222 | 0.2927 |
Onchocerca volvulus | 0.0007 | 0.0033 | 0.0038 | |
Schistosoma mansoni | coup transcription factor | 0.0006 | 0.0006 | 0.0006 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.1517 | 0.1998 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0006 | 0.0006 | 0.0008 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.1517 | 0.1517 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0026 | 0.0708 | 0.0933 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0232 | 0.0305 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0032 | 0.0908 | 0.2803 |
Mycobacterium tuberculosis | Conserved protein | 0.0021 | 0.0521 | 0.0546 |
Schistosoma mansoni | hypothetical protein | 0.0026 | 0.0708 | 0.0708 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0006 | 0.0006 | 0.0008 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0012 | 0.0232 | 0.0232 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0012 | 0.0232 | 0.0367 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0012 | 0.0232 | 0.0367 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0209 | 0.7083 | 0.8958 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0006 | 0.0006 | 0.001 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0232 | 0.0305 |
Brugia malayi | hypothetical protein | 0.0021 | 0.0531 | 0.0699 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0012 | 0.0232 | 0.0305 |
Trypanosoma brucei | trypanothione reductase | 0.0091 | 0.2993 | 1 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0012 | 0.0232 | 0.0305 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0012 | 0.0232 | 0.0305 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0006 | 0.0006 | 0.001 |
Brugia malayi | MH2 domain containing protein | 0.0069 | 0.2222 | 0.2927 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0021 | 0.0521 | 0.147 |
Loa Loa (eye worm) | pyridine nucleotide-disufhide oxidoreductase | 0.0008 | 0.0095 | 0.0125 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0186 | 0.631 | 0.8313 |
Schistosoma mansoni | glutamate synthase | 0.0008 | 0.0095 | 0.0095 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0006 | 0.0008 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0021 | 0.0531 | 0.0841 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0007 | 0.0033 | 0.0033 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0232 | 0.0305 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0006 | 0.0006 | 0.0008 |
Onchocerca volvulus | 0.0012 | 0.0232 | 0.0268 | |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0012 | 0.0232 | 0.0367 |
Plasmodium vivax | hypothetical protein, conserved | 0.0021 | 0.0521 | 0.147 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0006 | 0.0006 | 0.001 |
Echinococcus multilocularis | sulfide:quinone oxidoreductase | 0.0008 | 0.0095 | 0.0151 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0033 | 0.0044 |
Schistosoma mansoni | nuclear hormone receptor | 0.0006 | 0.0006 | 0.0006 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0032 | 0.0908 | 0.0908 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.1517 | 0.2404 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0006 | 0.0006 | 0.0008 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0032 | 0.0908 | 0.2803 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0012 | 0.0232 | 0.0305 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0021 | 0.0521 | 0.0521 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0521 | 0.0687 |
Onchocerca volvulus | 0.0008 | 0.0095 | 0.011 | |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0092 | 0.3012 | 0.4774 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0012 | 0.0232 | 0.0367 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0012 | 0.0232 | 0.0305 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0033 | 0.0044 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0012 | 0.0232 | 0.0367 |
Schistosoma mansoni | thyroid hormone receptor | 0.0079 | 0.2558 | 0.2558 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0032 | 0.0908 | 0.2803 |
Brugia malayi | glutamate synthase | 0.0008 | 0.0095 | 0.0125 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0006 | 0.0006 | 0.0006 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0032 | 0.0908 | 0.2803 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.1517 | 0.2404 |
Loa Loa (eye worm) | beta-lactamase | 0.0021 | 0.0521 | 0.0687 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0521 | 0.0687 |
Brugia malayi | Cation transporter family protein | 0.0012 | 0.0232 | 0.0305 |
Schistosoma mansoni | nAChR subunit | 0.0012 | 0.0232 | 0.0232 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0186 | 0.631 | 0.8313 |
Onchocerca volvulus | 0.0007 | 0.0033 | 0.0038 | |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0006 | 0.0006 | 0.0008 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0006 | 0.0006 | 0.0008 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0232 | 0.0305 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0012 | 0.0232 | 0.0367 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0026 | 0.0708 | 0.1123 |
Schistosoma mansoni | hypothetical protein | 0.0026 | 0.0708 | 0.0708 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0012 | 0.0232 | 0.0367 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0232 | 0.0305 |
Echinococcus granulosus | apoptosis inducing factor 1 mitochondrial | 0.0008 | 0.0095 | 0.0151 |
Echinococcus multilocularis | nAChR subunit | 0.0012 | 0.0232 | 0.0367 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0012 | 0.0232 | 0.0367 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0021 | 0.0521 | 0.147 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0007 | 0.0033 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0033 | 0.0044 |
Loa Loa (eye worm) | ACC-1 protein | 0.0012 | 0.0232 | 0.0305 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0006 | 0.0006 | 0.0008 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0006 | 0.0006 | 0.001 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0006 | 0.0006 | 0.001 |
Mycobacterium leprae | Probable lipase LipE | 0.0021 | 0.0521 | 0.0546 |
Onchocerca volvulus | 0.0012 | 0.0232 | 0.0268 | |
Echinococcus granulosus | FTZ F1 alpha | 0.0006 | 0.0006 | 0.001 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0919 | 0.121 |
Echinococcus multilocularis | GPCR, family 2 | 0.0026 | 0.0708 | 0.1123 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0006 | 0.0006 | 0.0007 |
Schistosoma mansoni | nAChR subunit | 0.0012 | 0.0232 | 0.0232 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0012 | 0.0232 | 0.0305 |
Plasmodium falciparum | thioredoxin reductase | 0.0032 | 0.0908 | 0.2803 |
Brugia malayi | ecdysteroid receptor | 0.0006 | 0.0006 | 0.0008 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0232 | 0.0305 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0232 | 0.7895 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0232 | 0.7895 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0021 | 0.0521 | 0.147 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0021 | 0.0521 | 0.0546 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0006 | 0.0006 | 0.0008 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0006 | 0.0006 | 0.0008 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0008 | 0.0095 | 0.0151 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.1517 | 0.1517 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0232 | 0.0305 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0012 | 0.0232 | 0.0367 |
Schistosoma mansoni | glutamate synthase | 0.0008 | 0.0095 | 0.0095 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0032 | 0.0919 | 0.1456 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0012 | 0.0232 | 0.0305 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0006 | 0.0006 | 0.001 |
Schistosoma mansoni | nAChR subunit | 0.0012 | 0.0232 | 0.0232 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0021 | 0.0521 | 0.0687 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0032 | 0.0919 | 0.0919 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.0186 | 0.631 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0032 | 0.0908 | 0.1196 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0021 | 0.0531 | 0.0531 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.1517 | 0.2404 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0006 | 0.0008 |
Loa Loa (eye worm) | glutathione reductase | 0.0091 | 0.2993 | 0.3944 |
Onchocerca volvulus | 0.0006 | 0.0006 | 0.0007 | |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0021 | 0.0521 | 0.5244 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0021 | 0.0521 | 0.0497 |
Onchocerca volvulus | 0.0012 | 0.0232 | 0.0268 | |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0012 | 0.0232 | 0.0367 |
Mycobacterium tuberculosis | Conserved protein | 0.0021 | 0.0521 | 0.0546 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0032 | 0.0908 | 1 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0021 | 0.0521 | 0.0546 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0026 | 0.0708 | 0.0933 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0006 | 0.0006 | 0.001 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0073 | 0.2354 | 0.373 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0021 | 0.0521 | 0.0497 |
Mycobacterium ulcerans | hypothetical protein | 0.0021 | 0.0521 | 0.5244 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0232 | 0.0305 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0012 | 0.0232 | 0.0305 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0006 | 0.0006 | 0.0008 |
Schistosoma mansoni | nAChR subunit | 0.0012 | 0.0232 | 0.0232 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0021 | 0.0521 | 0.0546 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.1761 | 0.1761 |
Brugia malayi | NADPH:adrenodoxin oxidoreductase, mitochondrial precursor | 0.0008 | 0.0095 | 0.0125 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0012 | 0.0232 | 0.0305 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1761 | 0.232 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0006 | 0.0006 | 0.0008 |
Plasmodium falciparum | glutathione reductase | 0.0091 | 0.2993 | 1 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0012 | 0.0232 | 0.0367 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0232 | 0.0305 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0031 | 0.0878 | 0.1391 |
Schistosoma mansoni | hypothetical protein | 0.0026 | 0.0708 | 0.0708 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0006 | 0.0008 |
Schistosoma mansoni | nAChR subunit | 0.0012 | 0.0232 | 0.0232 |
Brugia malayi | beta-lactamase family protein | 0.0021 | 0.0521 | 0.0687 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0012 | 0.0232 | 0.0367 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.1517 | 0.2404 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0006 | 0.0006 | 0.0006 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0091 | 0.2993 | 0.3716 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0521 | 0.0687 |
Activity type | Activity value | Assay description | Source | Reference | |||||
---|---|---|---|---|---|---|---|---|---|
OD (functional) | = 12.5 mg kg-1 |
In vivo antileukemic activity was determined on L1210 leukemia cell in mice (O.D.=optimal (non-toxic) dose
ChEMBL.
|
10866398
|
T/C (functional)
|
= 157 %
|
In vivo antileukemic activity was determined in mice infected with L1210 leukemia cell after intravenous administration (T/C=median survival time of treated versus untreated mice 10)
|
ChEMBL.
|
10866398
|
|
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.